CN110755583A

CN110755583A - Traditional Chinese medicine composition for treating postpartum rheumatism

Info

Publication number: CN110755583A
Application number: CN201810828112.4A
Authority: CN
Inventors: 侯丽萍; 石秀峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-07-25
Filing date: 2018-07-25
Publication date: 2020-02-07

Abstract

The invention provides a traditional Chinese medicine composition for treating postpartum rheumatism, which is prepared from the following raw material medicines: 12-55 parts of red ginseng, 25-65 parts of angelica, 25-65 parts of ligusticum wallichii, 52-100 parts of parasitic loranthus, 18-53 parts of bighead atractylodes rhizome, 25-65 parts of divaricate saposhnikovia root, 35-90 parts of allium macrostemon, 38-72 parts of achyranthes bidentata, 35-90 parts of radix angelicae pubescentis, 25-65 parts of notopterygium root, 35-90 parts of prepared rehmannia root, 25-65 parts of liquorice, 25-65 parts of cinnamon and 35-90 parts of ginger. The traditional Chinese medicine composition has the total effective rate of treating postpartum rheumatism of 82.0 percent, has no obvious toxic or side effect and is safe to use.

Description

Traditional Chinese medicine composition for treating postpartum rheumatism

Technical Field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating postpartum rheumatism, and belongs to the field of medicines.

Background

The postpartum rheumatism refers to a disease of limb or joint pain and muscular spasm caused by qi and blood weakness after postpartum or induced abortion and gynecological operation trauma, external infection of wind-cold-dampness pathogen and blood stasis retention of women, and symptoms such as general pain, pain without fixed position and the like appear, so that the postpartum rheumatism women are suffered from great pain after clinical delay and difficult healing. In ancient literature of traditional Chinese medicine, the names of "postpartum pain all over the body", "postpartum arthralgia", "postpartum lumbago", "postpartum stroke" are named.

The traditional Chinese medicine researches consider that postpartum women suffer from qi and blood deficiency, return exogenous pathogenic factors, cause qi and blood stasis, do not honor or cause pain due to obstruction, start from the whole treatment, treat both symptoms and root causes, and have obvious advantages.

Chinese patent CN101724539A discloses a Chinese medicinal health wine with effects of enhancing immunity, resisting aging, promoting blood circulation and relieving pain, which is prepared from radix Angelicae sinensis, radix Paeoniae alba, radix rehmanniae, Achyranthis radix, cortex Phellodendri, Eucommiae cortex, radix Saposhnikoviae, radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, radix Angelicae Pubescentis, Arecae semen, cortex Cinnamomi, and Glycyrrhrizae radix;

liu Jian in "TCM thought of rheumatism" proposes treatment according to etiology and pathogenesis of rheumatism: modified Fangji Huangqi Tang (radix Stephaniae Tetrandrae, radix Saposhnikoviae, radix astragali, Atractylodis rhizoma, radix Gentianae Marcrophyllae, Notopterygii rhizoma, radix Angelicae Pubescentis, ramulus Cinnamomi, radix Angelicae sinensis, Poria, Glycyrrhrizae radix, rhizoma Zingiberis recens, and fructus Jujubae) for treating rheumatism due to obstruction of collaterals by wind-cold during active period; modified Xuanbi Tang and Sanmiao san (radix Stephaniae Tetrandrae, faeces Bombycis, Coicis semen, fructus forsythiae, rhizoma Atractylodis, semen Phaseoli, pulvis Talci, fructus Gardeniae, cortex Phellodendri, and Achyranthis radix) for treating damp-heat arthralgia type rheumatism during active stage; in the remission stage, phlegm stasis and blood stasis blocking type rheumatism is prepared by mixing pain-relieving stasis-dispelling decoction with Zhimi Poria pill (radix Angelicae sinensis, radix Gentianae Marcrophyllae, semen Persicae, Carthami flos, rhizoma Cyperi, Lumbricus, Oletum Trogopterori, Myrrha, Notopterygii rhizoma, rhizoma Ligustici Chuanxiong, Achyranthis radix, Glycyrrhrizae radix, rhizoma Pinelliae and fructus Aurantii); the prescription for treating rheumatism due to deficiency of qi and blood comprises SHIQUANDABU decoction and radix Angelicae Pubescentis and herba Taxilli decoction (radix Codonopsis, radix Angelicae Pubescentis, herba Taxilli, radix Gentianae Marcrophyllae, radix Saposhnikoviae, herba asari, radix Angelicae sinensis, radix Paeoniae, rhizoma Ligustici Chuanxiong, rehmanniae radix, Eucommiae cortex, Achyranthis radix, Poria, radix astragali, Atractylodis rhizoma, and cortex Cinnamomi).

Sun Weifeng summarized in the experience of diagnosis and treatment of postpartum rheumatism in "the collection of experience of diagnosis and treatment of postpartum rheumatism" that postpartum rheumatism is caused by deficiency of qi and blood, unsmooth blood circulation, blood stasis, and insufficiency of liver and kidney, and it is mainly used for treating deficiency of qi and blood, stasis caused by unsmooth circulation, and tendons and vessels caused by malnutrition of qi and blood, and it is usually used in the first prescription of postpartum rheumatism: radix rehmanniae Preparata, radix Paeoniae alba, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix astragali, Atractylodis rhizoma, radix Codonopsis, Poria, caulis Spatholobi, herba Taxilli, Achyranthis radix, radix Dipsaci, and fructus Jujubae; the recipe of the traditional Chinese medicine composition for treating postpartum rheumatism is the middle stage of the disease course between 100 days and 6 months, the disease course is delayed and difficult to cure, the symptoms are repeatedly attacked, and the traditional Chinese medicine composition is advocated for removing dampness, and is prepared from radix angelicae pubescentis, parasitic loranthus, asarum, gentiana macrophylla, cinnamon, radix sileris, paniculate swallowwort root, eucommia ulmoides, achyranthes bidentata, teasel root, angelica sinensis, prepared rehmannia root and liquorice.

There is no ideal treatment method for postpartum rheumatism and western medicine, the side effects of the drugs such as hormone are more, and the drugs are easy to recur after stopping taking the drug.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine composition for treating postpartum rheumatism.

As one aspect of the invention, the invention provides a traditional Chinese medicine composition for treating postpartum rheumatism, which is prepared from the following raw material medicines: ginseng radix Rubri, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, herba Taxilli, Atractylodis rhizoma, radix Saposhnikoviae, Bulbus Allii Macrostemi, Achyranthis radix, radix Angelicae Pubescentis, Notopterygii rhizoma, radix rehmanniae Preparata, Glycyrrhrizae radix, cortex Cinnamomi, and rhizoma Zingiberis recens.

In a specific embodiment, the traditional Chinese medicine composition is prepared from the following raw material medicines: 10-60 parts of red ginseng, 22-80 parts of angelica, 22-80 parts of ligusticum wallichii, 45-110 parts of parasitic loranthus, 15-60 parts of bighead atractylodes rhizome, 22-80 parts of divaricate saposhnikovia root, 30-100 parts of allium macrostemon, 32-85 parts of achyranthes bidentata, 30-100 parts of radix angelicae pubescentis, 22-80 parts of notopterygium root, 30-100 parts of prepared rehmannia root, 22-80 parts of liquorice, 22-80 parts of cinnamon and 30-100 parts of ginger.

In a preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw material medicines: 12-55 parts of red ginseng, 25-65 parts of angelica, 25-65 parts of ligusticum wallichii, 52-100 parts of parasitic loranthus, 18-53 parts of bighead atractylodes rhizome, 25-65 parts of divaricate saposhnikovia root, 35-90 parts of allium macrostemon, 38-72 parts of achyranthes bidentata, 35-90 parts of radix angelicae pubescentis, 25-65 parts of notopterygium root, 35-90 parts of prepared rehmannia root, 25-65 parts of liquorice, 25-65 parts of cinnamon and 35-90 parts of ginger.

In a further preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw material medicines: 20-40 parts of red ginseng, 35-55 parts of angelica, 35-55 parts of ligusticum wallichii, 60-90 parts of parasitic loranthus, 25-45 parts of bighead atractylodes rhizome, 35-55 parts of divaricate saposhnikovia root, 45-75 parts of allium macrostemon, 45-65 parts of achyranthes bidentata, 45-75 parts of radix angelicae pubescentis, 35-55 parts of notopterygium root, 45-75 parts of prepared rehmannia root, 35-55 parts of liquorice, 35-55 parts of cinnamon and 45-75 parts of ginger.

In a further preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw material medicines: 25-35 parts of red ginseng, 40-50 parts of angelica, 40-50 parts of ligusticum wallichii, 70-80 parts of parasitic loranthus, 30-40 parts of bighead atractylodes rhizome, 40-50 parts of divaricate saposhnikovia root, 55-65 parts of allium macrostemon, 50-60 parts of achyranthes bidentata, 55-65 parts of radix angelicae pubescentis, 40-50 parts of notopterygium root, 55-65 parts of prepared rehmannia root, 40-50 parts of liquorice, 40-50 parts of cinnamon and 55-65 parts of ginger.

In the most preferred embodiment, the Chinese medicinal composition is prepared from the following raw material medicaments: 30 parts of red ginseng, 45 parts of angelica, 45 parts of ligusticum wallichii, 75 parts of parasitic loranthus, 35 parts of bighead atractylodes rhizome, 45 parts of divaricate saposhnikovia root, 60 parts of allium macrostemon, 55 parts of achyranthes bidentata, 60 parts of radix angelicae pubescentis, 45 parts of notopterygium root, 60 parts of prepared rehmannia root, 45 parts of liquorice, 45 parts of cinnamon and 60 parts of ginger;

or, the traditional Chinese medicine composition is prepared from the following raw material medicines: 26 parts of red ginseng, 48 parts of angelica, 42 parts of ligusticum wallichii, 78 parts of parasitic loranthus, 31 parts of bighead atractylodes rhizome, 49 parts of divaricate saposhnikovia root, 56 parts of allium macrostemon, 59 parts of achyranthes bidentata, 56 parts of radix angelicae pubescentis, 49 parts of notopterygium root, 56 parts of prepared rehmannia root, 49 parts of liquorice, 42 parts of cinnamon and 64 parts of ginger;

or, the traditional Chinese medicine composition is prepared from the following raw material medicines: 34 parts of red ginseng, 42 parts of angelica, 49 parts of ligusticum wallichii, 71 parts of parasitic loranthus, 39 parts of bighead atractylodes rhizome, 42 parts of divaricate saposhnikovia root, 64 parts of allium macrostemon, 51 parts of achyranthes bidentata, 64 parts of radix angelicae pubescentis, 42 parts of notopterygium root, 64 parts of prepared rehmannia root, 41 parts of liquorice, 49 parts of cinnamon and 56 parts of ginger.

In a preferred embodiment, the licorice is honey-fried licorice.

The traditional Chinese medicine composition can be a composition formed by crushing and mixing raw material medicines, can also be an extract obtained by mixing or extracting the raw material medicines independently, or an effective part obtained by further refining and purifying the extract, and can also be a conventional preparation form prepared by adding pharmaceutically acceptable auxiliary materials.

Wherein the extraction method comprises decocting extraction, reflux extraction, immersion extraction, ultrasonic extraction, percolation extraction, microwave extraction, etc.; the purification method comprises water extraction and alcohol precipitation, alkali dissolution and acid precipitation and various column chromatography purification methods, such as a macroporous resin column, a silica gel column, a reverse phase column and the like; the conventional dosage forms include but are not limited to injections, capsules, tablets, granules, gels, sustained-release agents, oral liquids, dropping pills or nano preparations; the pharmaceutically acceptable auxiliary materials comprise: fillers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives, bases, and the like. The filler comprises: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; the disintegrating agent comprises: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, crospolyvinylpyrrolidone, low-substituted hydroxypropylcellulose, croscarmellose sodium, etc.; the lubricant comprises: magnesium stearate, sodium lauryl sulfate, talc, silica, and the like; the suspending agent comprises: polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, and the like; the binder includes starch slurry, polyvinylpyrrolidone, hydroxypropyl methylcellulose, etc.

As another aspect of the present invention, the traditional Chinese medicine composition of the present invention can also use the extract of the raw material medicine as a raw material, so the present invention also provides a traditional Chinese medicine composition, which is prepared from the following raw materials:

in a specific embodiment, the traditional Chinese medicine composition is prepared from the following raw materials: 10-60 parts of red ginseng extract, 22-80 parts of angelica extract, 22-80 parts of ligusticum wallichii extract, 45-110 parts of parasitic loranthus extract, 15-60 parts of bighead atractylodes rhizome extract, 22-80 parts of divaricate saposhnikovia root extract, 30-100 parts of allium macrostemon extract, 32-85 parts of achyranthes root extract, 30-100 parts of radix angelicae pubescentis extract, 22-80 parts of notopterygium root extract, 30-100 parts of prepared rehmannia root extract, 22-80 parts of liquorice extract, 22-80 parts of cinnamon extract and 30-100 parts of ginger extract.

In a preferred embodiment, the Chinese medicinal composition is prepared from the following raw materials: 12-55 parts of red ginseng extract, 25-65 parts of angelica extract, 25-65 parts of ligusticum wallichii extract, 52-100 parts of parasitic loranthus extract, 18-53 parts of bighead atractylodes rhizome extract, 25-65 parts of divaricate saposhnikovia root extract, 35-90 parts of allium macrostemon extract, 38-72 parts of achyranthes root extract, 35-90 parts of radix angelicae pubescentis extract, 25-65 parts of notopterygium root extract, 35-90 parts of prepared rehmannia root extract, 25-65 parts of liquorice extract, 25-65 parts of cinnamon extract and 35-90 parts of ginger extract.

In a further preferred embodiment, the Chinese medicinal composition is prepared from the following raw materials: 20-40 parts of red ginseng extract, 35-55 parts of angelica extract, 35-55 parts of ligusticum wallichii extract, 60-90 parts of parasitic loranthus extract, 25-45 parts of bighead atractylodes rhizome extract, 35-55 parts of divaricate saposhnikovia root extract, 45-75 parts of allium macrostemon extract, 45-65 parts of achyranthes root extract, 45-75 parts of radix angelicae pubescentis extract, 35-55 parts of notopterygium root extract, 45-75 parts of prepared rehmannia root extract, 35-55 parts of liquorice extract, 35-55 parts of cinnamon extract and 45-75 parts of ginger extract.

In a further preferred embodiment, the Chinese medicinal composition is prepared from the following raw materials: 25-35 parts of red ginseng extract, 40-50 parts of angelica extract, 40-50 parts of ligusticum wallichii extract, 70-80 parts of parasitic loranthus extract, 30-40 parts of bighead atractylodes rhizome extract, 40-50 parts of divaricate saposhnikovia root extract, 55-65 parts of allium macrostemon extract, 50-60 parts of achyranthes root extract, 55-65 parts of radix angelicae pubescentis extract, 40-50 parts of notopterygium root extract, 55-65 parts of prepared rehmannia root extract, 40-50 parts of liquorice extract, 40-50 parts of cinnamon extract and 55-65 parts of ginger extract.

In the most preferred embodiment, the Chinese medicinal composition is prepared from the following raw materials: 30 parts of red ginseng extract, 45 parts of angelica extract, 45 parts of ligusticum wallichii extract, 75 parts of parasitic loranthus extract, 35 parts of bighead atractylodes rhizome extract, 45 parts of divaricate saposhnikovia root extract, 60 parts of allium macrostemon extract, 55 parts of achyranthes bidentata extract, 60 parts of radix angelicae pubescentis extract, 45 parts of notopterygium root extract, 60 parts of prepared rehmannia root extract, 45 parts of liquorice extract, 45 parts of cinnamon extract and 60 parts of ginger extract;

or, the traditional Chinese medicine composition is prepared from the following raw materials: 26 parts of red ginseng extract, 48 parts of angelica extract, 42 parts of ligusticum wallichii extract, 78 parts of parasitic loranthus extract, 31 parts of bighead atractylodes rhizome extract, 49 parts of divaricate saposhnikovia root extract, 56 parts of allium macrostemon extract, 59 parts of achyranthes bidentata extract, 56 parts of radix angelicae pubescentis extract, 49 parts of notopterygium root extract, 56 parts of prepared rehmannia root extract, 49 parts of liquorice extract, 42 parts of cinnamon extract and 64 parts of ginger extract;

or, the traditional Chinese medicine composition is prepared from the following raw materials: 34 parts of red ginseng extract, 42 parts of angelica extract, 49 parts of ligusticum wallichii extract, 71 parts of parasitic loranthus extract, 39 parts of bighead atractylodes rhizome extract, 42 parts of divaricate saposhnikovia root extract, 64 parts of allium macrostemon extract, 51 parts of achyranthes bidentata extract, 64 parts of radix angelicae pubescentis extract, 42 parts of notopterygium root extract, 64 parts of prepared rehmannia root extract, 41 parts of liquorice extract, 49 parts of cinnamon extract and 56 parts of ginger extract.

As a preferred embodiment, the extracts are water extracts of the respective raw materials.

As a second aspect of the invention, the invention provides application of the traditional Chinese medicine composition in preparing a medicine for treating postpartum rheumatism.

The raw materials are collected in the 'Chinese pharmacopoeia' 2015 edition, and the processing method is the 'pharmacopoeia' recording method.

In the formula of the invention, the red ginseng, the angelica, the ligusticum wallichii, the white paeony root, the prepared rhizome of rehmannia, the honey-fried licorice root and the bighead atractylodes rhizome are monarch drugs which can greatly tonify qi and blood and tonify the deficiency of the body; divaricate saposhnikovia root, doubleteeth pubescent angelica root, incised notopterygium rhizome, Chinese taxillus twig, longstamen onion bulb and cassia bark are used as ministerial medicines for warming, nourishing and tonifying and liver and kidney dispelling wind; ginger, rhizoma Zingiberis recens, as an adjuvant and guiding drug, regulates the stomach and regulates the middle-warmer.

The traditional Chinese medicine composition has the total effective rate of treating postpartum rheumatism of 82.0 percent, has no obvious toxic or side effect, is safe to use, and is worthy of further clinical popularization and use.

Detailed Description

Example 1

The formula is as follows: 30g of red ginseng, 45g of angelica, 45g of ligusticum wallichii, 75g of parasitic loranthus, 35g of bighead atractylodes rhizome, 45g of divaricate saposhnikovia root, 60g of allium macrostemon, 55g of achyranthes bidentata, 60g of radix angelicae pubescentis, 45g of notopterygium root, 60g of prepared rehmannia root, 45g of liquorice, 45g of cinnamon and 60g of ginger;

the preparation method comprises the following steps:

decocting the above fourteen medicines in water twice, the first time for 2 hours and the second time for 1.5 hours, mixing decoctions, filtering, concentrating the filtrate to relative density of 1.10(80 deg.C), standing, filtering, adjusting the total amount of the filtrate to 1000ml, stirring, packaging, and sterilizing.

Example 2

The formula is as follows: 26g of red ginseng, 48g of angelica, 42g of ligusticum wallichii, 78g of parasitic loranthus, 31g of bighead atractylodes rhizome, 49g of divaricate saposhnikovia root, 56g of allium macrostemon, 59g of achyranthes bidentata, 56g of radix angelicae pubescentis, 49g of notopterygium root, 56g of prepared rehmannia root, 49g of liquorice, 42g of cinnamon and 64g of ginger;

the preparation method comprises the following steps:

Example 3

The formula is as follows: 34g of red ginseng, 42g of angelica, 49g of ligusticum wallichii, 71g of parasitic loranthus, 39g of bighead atractylodes rhizome, 42g of divaricate saposhnikovia root, 64g of allium macrostemon, 51g of achyranthes bidentata, 64g of radix angelicae pubescentis, 42g of notopterygium root, 64g of prepared rehmannia root, 41g of liquorice, 49g of cinnamon and 56g of ginger;

the preparation method comprises the following steps:

the fourteen medicines are added with water and ultrasonically extracted twice, each time for 40min, the extracting solutions are combined and filtered, the filtrate is concentrated to the relative density of 1.10(80 ℃), and tablet auxiliary materials are added to prepare the tablet.

Example 4

The formula is as follows: 21g of red ginseng, 54g of angelica, 36g of ligusticum wallichii, 88g of parasitic loranthus, 26g of bighead atractylodes rhizome, 54g of divaricate saposhnikovia root, 46g of allium macrostemon, 64g of achyranthes bidentata, 46g of radix angelicae pubescentis, 54g of notopterygium root, 46g of prepared rehmannia root, 53g of liquorice, 36g of cinnamon and 74g of ginger;

the preparation method comprises the following steps:

percolating the above fourteen medicinal materials with water, filtering the extractive solution, concentrating the filtrate to relative density of 1.10(80 deg.C), adding granule adjuvants, and making into granule.

Example 5

The formula is as follows: 39g of red ginseng, 36g of angelica, 54g of ligusticum wallichii, 62g of parasitic loranthus, 44g of bighead atractylodes rhizome, 36g of divaricate saposhnikovia root, 74g of allium macrostemon, 46g of achyranthes bidentata, 74g of radix angelicae pubescentis, 36g of notopterygium root, 74g of prepared rehmannia root, 36g of liquorice, 54g of cinnamon and 46g of ginger;

the preparation method comprises the following steps:

reflux-extracting the above fourteen materials with water twice, the first time for 2 hours and the second time for 1.5 hours, mixing decoctions, filtering, concentrating the filtrate to relative density of 1.10(80 deg.C), standing, filtering, adjusting the total amount of the filtrate to 1000ml, stirring, packaging, and sterilizing.

Example 6

The formula is as follows: 22g of red ginseng, 50g of angelica, 38g of ligusticum wallichii, 78g of parasitic loranthus, 22g of bighead atractylodes rhizome, 51g of divaricate saposhnikovia root, 48g of allium macrostemon, 62g of achyranthes bidentata, 47g of radix angelicae pubescentis, 49g of notopterygium root, 72g of prepared rehmannia root, 38g of liquorice, 38g of cinnamon and 70g of ginger;

the preparation method comprises the following steps: the fourteen medicines are added with water and ultrasonically extracted twice, each time for 40min, the extracting solutions are combined and filtered, the filtrate is concentrated to the relative density of 1.10(80 ℃), and tablet auxiliary materials are added to prepare the tablet.

Example 7

The formula is as follows: 54g of red ginseng, 26g of angelica, 63g of ligusticum wallichii, 53g of parasitic loranthus, 52g of bighead atractylodes rhizome, 27g of divaricate saposhnikovia root, 88g of allium macrostemon, 39g of achyranthes bidentata, 89g of radix angelicae pubescentis, 27g of notopterygium root, 89g of prepared rehmannia root, 26g of liquorice, 64g of cinnamon and 36g of ginger;

the preparation method comprises the following steps: decocting the above fourteen medicines in water twice, the first time for 2 hours and the second time for 1.5 hours, mixing decoctions, filtering, concentrating the filtrate to relative density of 1.10(80 deg.C), standing, filtering, adjusting the total amount of the filtrate to 1000ml, stirring, packaging, and sterilizing.

Example 8

The formula is as follows: 28g of red ginseng, 48g of angelica, 44 parts of ligusticum wallichii, 76g of parasitic loranthus, 33g of bighead atractylodes rhizome, 47g of divaricate saposhnikovia root, 58g of allium macrostemon, 57g of achyranthes bidentata, 59g of radix angelicae pubescentis, 47g of notopterygium root, 57g of prepared rehmannia root, 48g of liquorice, 41g of cinnamon and 62g of ginger;

the preparation method comprises the following steps: the fourteen medicines are added with water and ultrasonically extracted twice, each time for 40min, the extracting solutions are combined, filtered, the filtrate is concentrated to the relative density of 1.10(80 ℃), and capsule auxiliary materials are added to prepare capsules.

Example 9

The formula is as follows: 33g of red ginseng, 43g of angelica, 47 parts of ligusticum wallichii, 73g of parasitic loranthus, 37g of bighead atractylodes rhizome, 44g of divaricate saposhnikovia root, 62g of allium macrostemon, 52g of achyranthes bidentata, 63g of radix angelicae pubescentis, 44g of notopterygium root, 63g of prepared rehmannia root, 42g of liquorice, 47g of cinnamon and 58g of ginger;

Example 10

The formula is as follows: 24g of red ginseng, 52g of angelica, 38g of ligusticum wallichii, 85g of parasitic loranthus, 28g of bighead atractylodes rhizome, 53g of divaricate saposhnikovia root, 50g of allium macrostemon, 63g of achyranthes bidentata, 48g of radix angelicae pubescentis, 51g of notopterygium root, 49g of prepared rehmannia root, 50g of liquorice, 39g of cinnamon and 70g of ginger;

the preparation method comprises the following steps: reflux-extracting the above fourteen materials with water twice, the first time for 2 hours and the second time for 1.5 hours, mixing decoctions, filtering, concentrating the filtrate to relative density of 1.10(80 deg.C), standing, filtering, adjusting the total amount of the filtrate to 1000ml, stirring, packaging, and sterilizing.

Example 11

The formula is as follows: 36g of red ginseng, 39g of angelica, 51g of ligusticum wallichii, 65g of parasitic loranthus, 42g of bighead atractylodes rhizome, 38g of divaricate saposhnikovia root, 70g of allium macrostemon, 48g of achyranthes bidentata, 72g of radix angelicae pubescentis, 38g of notopterygium root, 68g of prepared rehmannia root, 37g of liquorice, 52g of cinnamon and 48g of ginger;

Example 12

The formula is as follows: 30g of red ginseng extract, 45g of angelica extract, 45g of ligusticum wallichii extract, 75g of parasitic loranthus extract, 35g of bighead atractylodes rhizome extract, 45g of divaricate saposhnikovia root extract, 60g of allium macrostemon extract, 55g of achyranthes bidentata extract, 60g of radix angelicae pubescentis extract, 45g of notopterygium root extract, 60g of prepared rehmannia root extract, 45g of liquorice extract, 45g of cinnamon extract and 60g of ginger extract.

Example 13

The formula is as follows: 26g of red ginseng extract, 48g of angelica extract, 42g of ligusticum wallichii extract, 78g of parasitic loranthus extract, 31g of bighead atractylodes rhizome extract, 49g of divaricate saposhnikovia root extract, 56g of allium macrostemon extract, 59g of achyranthes bidentata extract, 56g of radix angelicae pubescentis extract, 49g of notopterygium root extract, 56g of prepared rehmannia root extract, 49g of liquorice extract, 42g of cinnamon extract and 64g of ginger extract.

Example 14

The formula is as follows: 34g of red ginseng extract, 42g of angelica extract, 49g of ligusticum wallichii extract, 71g of parasitic loranthus extract, 39g of bighead atractylodes rhizome extract, 42g of divaricate saposhnikovia root extract, 64g of allium macrostemon extract, 51g of achyranthes bidentata extract, 64g of radix angelicae pubescentis extract, 42g of notopterygium root extract, 64g of prepared rehmannia root extract, 41g of liquorice extract, 49g of cinnamon extract and 56g of ginger extract.

Example 15

The formula is as follows: 21g of red ginseng extract, 54g of angelica extract, 36g of ligusticum wallichii extract, 88g of parasitic loranthus extract, 26g of bighead atractylodes rhizome extract, 54g of divaricate saposhnikovia root extract, 46g of allium macrostemon extract, 64g of achyranthes bidentata extract, 46g of radix angelicae pubescentis extract, 54g of notopterygium root extract, 46g of prepared rehmannia root extract, 53g of liquorice extract, 36g of cinnamon extract and 74g of ginger extract.

Example 16

The formula is as follows: 39g of red ginseng extract, 36g of angelica extract, 54g of ligusticum wallichii extract, 62g of parasitic loranthus extract, 44g of bighead atractylodes rhizome extract, 36g of divaricate saposhnikovia root extract, 74g of allium macrostemon extract, 46g of achyranthes bidentata extract, 74g of radix angelicae pubescentis extract, 36g of notopterygium root extract, 74g of prepared rehmannia root extract, 36g of liquorice extract, 54g of cinnamon extract and 46g of ginger extract.

Example 17

The formula is as follows: 22g of red ginseng extract, 50g of angelica extract, 38g of ligusticum wallichii extract, 78g of parasitic loranthus extract, 22g of bighead atractylodes rhizome extract, 51g of divaricate saposhnikovia root extract, 48g of allium macrostemon extract, 62g of achyranthes bidentata extract, 47g of radix angelicae pubescentis extract, 49g of notopterygium root extract, 72g of prepared rehmannia root extract, 38g of liquorice extract, 38g of cinnamon extract and 70g of ginger extract.

Example 18

The formula is as follows: 28g of red ginseng extract, 48g of angelica extract, 44 parts of ligusticum wallichii extract, 76g of parasitic loranthus extract, 33g of bighead atractylodes rhizome extract, 47g of divaricate saposhnikovia root extract, 58g of allium macrostemon extract, 57g of achyranthes bidentata extract, 59g of radix angelicae pubescentis extract, 47g of notopterygium root extract, 57g of prepared rehmannia root extract, 48g of liquorice extract, 41g of cinnamon extract and 62g of ginger extract.

Example 19

The formula is as follows: 33g of red ginseng extract, 43g of angelica extract, 47 parts of ligusticum wallichii extract, 73g of parasitic loranthus extract, 37g of bighead atractylodes rhizome extract, 44g of divaricate saposhnikovia root extract, 62g of allium macrostemon extract, 52g of achyranthes bidentata extract, 63g of radix angelicae pubescentis extract, 44g of notopterygium root extract, 63g of prepared rehmannia root extract, 42g of liquorice extract, 47g of cinnamon extract and 58g of ginger extract.

Example 20

The formula is as follows: 24g of red ginseng extract, 52g of angelica extract, 38g of ligusticum wallichii extract, 85g of parasitic loranthus extract, 28g of bighead atractylodes rhizome extract, 53g of divaricate saposhnikovia root extract, 50g of allium macrostemon extract, 63g of achyranthes bidentata extract, 48g of radix angelicae pubescentis extract, 51g of notopterygium root extract, 49g of prepared rehmannia root extract, 50g of liquorice extract, 39g of cinnamon extract and 70g of ginger extract.

Example 21

The formula is as follows: 36g of red ginseng extract, 39g of angelica extract, 51g of ligusticum wallichii extract, 65g of parasitic loranthus extract, 42g of bighead atractylodes rhizome extract, 38g of divaricate saposhnikovia root extract, 70g of allium macrostemon extract, 48g of achyranthes bidentata extract, 72g of radix angelicae pubescentis extract, 38g of notopterygium root extract, 68g of prepared rehmannia root extract, 37g of liquorice extract, 52g of cinnamon extract and 48g of ginger extract.

The extracts described in examples 12-21 above are water extracts of the respective raw materials.

Comparative example 1

The formula is as follows: 65g of radix angelicae pubescentis, 65g of parasitic loranthus, 39g of gentiana macrophylla, 39g of divaricate saposhnikovia root, 26g of asarum, 39g of Chinese angelica, 39g of ligusticum wallichii, 39g of rehmannia, 39g of white paeony root, 39g of cinnamon, 39g of poria cocos, 65g of eucommia ulmoides, 65g of achyranthes bidentata, 65g of codonopsis pilosula and 26g of liquorice;

decocting the fifteen medicines with water twice, the first time is 2 hours, the second time is 1.5 hours, combining the decoctions, filtering, concentrating the filtrate to the relative density of 1.10(80 ℃), standing, filtering, adjusting the total amount of the filtrate to 1000ml, stirring uniformly, subpackaging and sterilizing to obtain the traditional Chinese medicine.

Effects of the embodiment

Clinical observations of the efficacy and safety of the composition of the present invention (hereinafter referred to as "SGYR") for the treatment of postpartum rheumatism were made in inpatients and outpatients of rheumatoid hospitals in taiyuan city between 3 months in 1995 and 12 months in 1995, and the results are summarized as follows:

1. criteria for selection of observed cases:

the method adopts a mode of combining disease differentiation and syndrome differentiation to select observation cases:

1.1 diagnostic criteria: refer to "practical traditional Chinese rheumatology" for the diagnostic criteria of postpartum bi-arthralgia:

1) onset of disease within postpartum whooping;

2) there is history of postpartum weak body experiencing exogenous pathogenic factors;

3) the main clinical manifestations are: limb joint and muscle pain, heaviness, swelling, soreness, numbness and difficulty in movement, accompanied by sweating, aversion to wind, tiredness, hypodynamia, soreness and weakness of waist and knees and the like;

4) other clear rheumatic diseases were excluded.

1.2 the traditional Chinese medicine syndrome differentiation standard: adopts syndrome differentiation and typing of Houli academy of Rheumatoid disease Hospital in Taiyuan.

Deficiency of both qi and blood: arthralgia, difficulty in flexion and extension, soreness and numbness of limbs, aggravation after activity, yellowish and lusterless complexion, shortness of breath, hypodynamia, palpitation, spontaneous perspiration, aversion to wind, aversion to cold, pale red tongue with thin and white coating, and thready and weak pulse.

1.3 inclusion case criteria:

i, according with the traditional Chinese medicine diagnosis standard and syndrome differentiation standard;

II, the test subject is voluntarily used, and can receive observation medicines to ensure the completion of the treatment course (more than 8 weeks except for the case of intolerance of side effects of the medicines).

1.4 rule of exclusion:

i, patients with serious organic diseases of vital organs such as heart, liver, kidney and the like and psychoses;

II, long-term application of steroid medicines or other Chinese and western medicines is not suitable for patients with drug withdrawal;

III, if the drug is not administered according to the prescription, the curative effect or data are not complete, which will affect the curative effect judgment and safety judgment.

2. Clinical observation indexes are as follows:

2.1 safety observation indexes:

i, inquiring whether the patient has gastrointestinal symptoms, rash and other adverse reactions and lactation conditions of the breast-feeding person.

II, general physical examination items.

III, performing routine tests on blood, urine and excrement; performing electrocardiographic examination; and (4) liver and kidney function examination.

2.2 observation indexes of curative effect:

i, joint pain index:

II, joint swelling index:

III, joint dysfunction index:

and IV, regularly inquiring the change conditions of subjective symptoms of aching and numb limbs, shortness of breath, hypodynamia, spontaneous perspiration, intolerance of wind and aversion to cold of the patient.

V, main detection indexes are as follows: blood sedimentation (ESR), anti-strepto 'O' (ASO), Rheumatoid Factor (RF) were routinely measured before and at the end of the treatment period, respectively.

3. General data:

all female patients in this group of cases were 23-36 years old, with an average age of 29.3 years, with 21 mammals; 39 cases in <1 year, 8 cases in 1-3 years, and 3 cases in >3 years. The two data are comparable (P >0.05) in three groups of 50 cases. .

4. The treatment method comprises the following steps:

the experimental group 1 adopts the traditional Chinese medicine composition 'SGYR' (prepared according to the formula and the preparation method of the group 1) of the invention, 20ml of the traditional Chinese medicine composition is taken each time, 3 times a day (equivalent to 42.3g of crude drugs) and the traditional Chinese medicine composition is taken after meals, and 8 weeks are a treatment course;

the experimental group 2 adopts the traditional Chinese medicine composition of the embodiment 7, 20ml each time, 3 times a day (equivalent to 44g crude drugs), and the traditional Chinese medicine composition is taken after meal, and 8 weeks is a treatment course;

experiment group 3 used 20ml of the Chinese medicinal composition of control example 1 each time, 3 times daily (equivalent to 41.3g crude drug), and was taken after meal for 8 weeks as a treatment course.

In the observation process, the observation case should not take the Chinese and western medicines taking the above observation symptoms as main indications and adopt other treatment methods aiming at the above symptoms.

5. The judgment standard of the curative effect is as follows: refer to the clinical research guidelines of new Chinese medicine for treating arthralgia.

Clinical cure: the symptoms and physical signs disappear, all physical and chemical examinations are not abnormal, and the life and workers can be normal.

The method has the following advantages: the symptoms and physical signs are obviously relieved, and the patients can participate in daily work and life.

And (4) invalidation: and no significant reduction or increase in symptoms or signs.

6. The observation results of the curative effect are as follows:

all groups of patients complete the treatment course according to the plan, and Chinese and western medicines and other treatment methods which take the disease as the main indication are not used when the patients are brought into the observation cases. The results are shown in Table 1.

TABLE 1 results of clinical experiments

7. Safety observations:

7.1 adverse reactions:

in the treatment process, no obvious discomfort reaction is seen in all cases of the group, and the prescribed course of treatment can be smoothly completed. Meanwhile, the lactation woman can normally nurse milk without the phenomenon of delactation.

7.2 safety detection indexes:

in all cases of the group, detailed physical examination is carried out before and after treatment, and routine examination of blood, urine and stool and examination of electrocardiogram and liver and kidney function are carried out, so that abnormal changes are not found.

8. As a result:

in clinic, postpartum women have symptoms such as limb joint and muscle pain, heaviness, swelling, difficult movement and the like, and the doctor seeing a doctor usually cannot find out physical and chemical inspection abnormality and positive signs and cannot determine a certain rheumatic disease, so that the doctor only needs to correspondingly treat calcium deficiency and nutrient deficiency to cause long-term existence of the pathological state, not only brings physical and mental pain to patients, but also increases treatment difficulty due to delay of treatment time. The TCM theory has long been found to be different from the common arthralgia syndrome due to wind-damp, and has accumulated abundant experience in clinical practice. Generally speaking, a woman needs a lot of qi and blood to breed a fetus during pregnancy, which is liable to cause deficiency of qi and blood, if excessive blood loss occurs after delivery, or the labor is too long, excessive energy loss or postpartum lochiorrhea is not clear, qi and blood are more deficient, wind, cold, dampness and other pathogens are easy to invade the body to cause postpartum rheumatism, most of the diseases are mainly deficiency of healthy qi, and the treatment should be performed with healthy qi strengthening as the first step or with healthy qi strengthening and pathogenic factor eliminating as the second step. The traditional Chinese medicine composition has the total effective rate of treating postpartum rheumatism of 82.0 percent, has no obvious toxic or side effect, is safe to use, and is worthy of further clinical popularization and use.

Claims

1. The traditional Chinese medicine composition for treating postpartum rheumatism is characterized by being prepared from the following raw material medicines: ginseng radix Rubri, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, herba Taxilli, Atractylodis rhizoma, radix Saposhnikoviae, Bulbus Allii Macrostemi, Achyranthis radix, radix Angelicae Pubescentis, Notopterygii rhizoma, radix rehmanniae Preparata, Glycyrrhrizae radix, cortex Cinnamomi, and rhizoma Zingiberis recens.

2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines:

12-55 parts of red ginseng, 25-65 parts of angelica, 25-65 parts of ligusticum wallichii, 52-100 parts of parasitic loranthus, 18-53 parts of bighead atractylodes rhizome, 25-65 parts of divaricate saposhnikovia root, 35-90 parts of allium macrostemon, 38-72 parts of achyranthes bidentata, 35-90 parts of radix angelicae pubescentis, 25-65 parts of notopterygium root, 35-90 parts of prepared rehmannia root, 25-65 parts of liquorice, 25-65 parts of cinnamon and 35-90 parts of ginger.

3. The traditional Chinese medicine composition of claim 2, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines:

20-40 parts of red ginseng, 35-55 parts of angelica, 35-55 parts of ligusticum wallichii, 60-90 parts of parasitic loranthus, 25-45 parts of bighead atractylodes rhizome, 35-55 parts of divaricate saposhnikovia root, 45-75 parts of allium macrostemon, 45-65 parts of achyranthes bidentata, 45-75 parts of radix angelicae pubescentis, 35-55 parts of notopterygium root, 45-75 parts of prepared rehmannia root, 35-55 parts of liquorice, 35-55 parts of cinnamon and 45-75 parts of ginger.

4. The traditional Chinese medicine composition of claim 3, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines:

25-35 parts of red ginseng, 40-50 parts of angelica, 40-50 parts of ligusticum wallichii, 70-80 parts of parasitic loranthus, 30-40 parts of bighead atractylodes rhizome, 40-50 parts of divaricate saposhnikovia root, 55-65 parts of allium macrostemon, 50-60 parts of achyranthes bidentata, 55-65 parts of radix angelicae pubescentis, 40-50 parts of notopterygium root, 55-65 parts of prepared rehmannia root, 40-50 parts of liquorice, 40-50 parts of cinnamon and 55-65 parts of ginger.

5. The traditional Chinese medicine composition of claim 4, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines: 30 parts of red ginseng, 45 parts of angelica, 45 parts of ligusticum wallichii, 75 parts of parasitic loranthus, 35 parts of bighead atractylodes rhizome, 45 parts of divaricate saposhnikovia root, 60 parts of allium macrostemon, 55 parts of achyranthes bidentata, 60 parts of radix angelicae pubescentis, 45 parts of notopterygium root, 60 parts of prepared rehmannia root, 45 parts of liquorice, 45 parts of cinnamon and 60 parts of ginger;

or 26 parts of red ginseng, 48 parts of angelica, 42 parts of ligusticum wallichii, 78 parts of loranthus parasiticus, 31 parts of bighead atractylodes rhizome, 49 parts of divaricate saposhnikovia root, 56 parts of allium macrostemon, 59 parts of achyranthes bidentata, 56 parts of radix angelicae pubescentis, 49 parts of notopterygium root, 56 parts of prepared rehmannia root, 49 parts of liquorice, 42 parts of cinnamon and 64 parts of ginger;

or 34 parts of red ginseng, 42 parts of angelica, 49 parts of ligusticum wallichii, 71 parts of loranthus parasiticus, 39 parts of bighead atractylodes rhizome, 42 parts of divaricate saposhnikovia root, 64 parts of allium macrostemon, 51 parts of achyranthes bidentata, 64 parts of radix angelicae pubescentis, 42 parts of notopterygium root, 64 parts of prepared rehmannia root, 41 parts of liquorice, 49 parts of cinnamon and 56 parts of ginger.

6. The traditional Chinese medicine composition of any one of claims 1 to 5, wherein the traditional Chinese medicine composition is a composition prepared by crushing and mixing raw materials, or an extract prepared by mixing or extracting the raw materials separately, or an effective part prepared by further refining and purifying the extract, or a conventional preparation prepared by adding pharmaceutically acceptable auxiliary materials.

7. The traditional Chinese medicine composition for treating postpartum rheumatism is characterized by being prepared from the following raw materials:

12-55 parts of red ginseng extract, 25-65 parts of angelica extract, 25-65 parts of ligusticum wallichii extract, 52-100 parts of parasitic loranthus extract, 18-53 parts of bighead atractylodes rhizome extract, 25-65 parts of divaricate saposhnikovia root extract, 35-90 parts of allium macrostemon extract, 38-72 parts of achyranthes root extract, 35-90 parts of radix angelicae pubescentis extract, 25-65 parts of notopterygium root extract, 35-90 parts of prepared rehmannia root extract, 25-65 parts of liquorice extract, 25-65 parts of cinnamon extract and 35-90 parts of ginger extract.

8. The traditional Chinese medicine composition of claim 7, wherein the traditional Chinese medicine composition is prepared from the following raw materials:

20-40 parts of red ginseng extract, 35-55 parts of angelica extract, 35-55 parts of ligusticum wallichii extract, 60-90 parts of parasitic loranthus extract, 25-45 parts of bighead atractylodes rhizome extract, 35-55 parts of divaricate saposhnikovia root extract, 45-75 parts of allium macrostemon extract, 45-65 parts of achyranthes root extract, 45-75 parts of radix angelicae pubescentis extract, 35-55 parts of notopterygium root extract, 45-75 parts of prepared rehmannia root extract, 35-55 parts of liquorice extract, 35-55 parts of cinnamon extract and 45-75 parts of ginger extract.

9. The traditional Chinese medicine composition of claim 7 or 8, wherein the extracts are water extracts of the raw materials respectively.

10. The use of a Chinese medicinal composition as claimed in any one of claims 1-5, 7-8 in the manufacture of a medicament for the treatment of postpartum rheumatism.