CN110743099A - Subcutaneous drug delivery device based on low-temperature plasma - Google Patents
Subcutaneous drug delivery device based on low-temperature plasma Download PDFInfo
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- CN110743099A CN110743099A CN201911076368.5A CN201911076368A CN110743099A CN 110743099 A CN110743099 A CN 110743099A CN 201911076368 A CN201911076368 A CN 201911076368A CN 110743099 A CN110743099 A CN 110743099A
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- plasma
- electrode
- drug delivery
- skin
- delivery device
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 27
- 238000007920 subcutaneous administration Methods 0.000 title claims abstract description 25
- 210000002381 plasma Anatomy 0.000 claims abstract description 98
- 239000003814 drug Substances 0.000 claims abstract description 42
- 210000003491 skin Anatomy 0.000 claims abstract description 29
- 230000015556 catabolic process Effects 0.000 claims abstract description 26
- 229940079593 drug Drugs 0.000 claims abstract description 21
- 238000002347 injection Methods 0.000 claims abstract description 18
- 239000007924 injection Substances 0.000 claims abstract description 18
- 238000010521 absorption reaction Methods 0.000 claims abstract description 7
- 210000004207 dermis Anatomy 0.000 claims abstract description 5
- 210000002615 epidermis Anatomy 0.000 claims abstract description 5
- 206010033675 panniculitis Diseases 0.000 claims description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 5
- 238000010254 subcutaneous injection Methods 0.000 abstract description 3
- 239000007929 subcutaneous injection Substances 0.000 abstract description 3
- 230000006378 damage Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000037324 pain perception Effects 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a subcutaneous drug delivery device based on low-temperature plasma, which consists of a plasma drug delivery electrode, a plasma breakdown electrode, a drug cabin and a multi-frequency pulse plasma power supply. The plasma administration electrode is used for puncturing the epidermis layer and the dermis layer of the skin to open an injection channel of the skin, the plasma breakdown electrode is used for injecting drugs into the channel opened in the plasma administration electrode, the drug cabin is used for storing the injected drugs, and the multi-frequency pulse plasma power supply is used for controlling the plasma breakdown electrode to generate different voltages and plasmas under different application scenes so as to control the breakdown condition of the skin. By using the subcutaneous drug delivery device based on low-temperature plasma disclosed by the invention, the pain of a human body on subcutaneous injection drug delivery can be relieved, and the effective absorption of drugs in the human body is improved.
Description
Technical Field
The invention relates to the technical field of subcutaneous drug delivery devices, in particular to a subcutaneous drug delivery device based on low-temperature plasma.
Background
At present, the drug delivery technology for puncturing the skin surface is based on a needle injection mode, but the needle injection mode often causes pain, inflammation or infection injury to the skin due to the large size of the needle. The subcutaneous drug delivery device based on low-temperature plasma injects the drug into the skin in a micro electrode needle hole mode by reducing the size of a needle head, so that the pain is reduced, and the damage to the skin tissue of a human body is reduced. In addition, the subcutaneous drug delivery device based on low-temperature plasma can better ensure the pharmacology of injected drugs, and the plasma discharge of the electrode to skin tissues improves the activity of the skin tissues, thereby better achieving the effect of drug absorption.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the present subcutaneous administration technology is to puncture skin directly through injection type needle hole and to inject, and the technology can cause pain to human skin due to the overlarge needle hole diameter, so the present invention can reduce the pain of human body by reducing the needle hole diameter, and the medicine injection position can effectively improve the medicine absorption by plasma treatment.
The technical scheme adopted by the invention is as follows: the subcutaneous drug delivery device based on low-temperature plasma is composed of a plasma drug delivery electrode, a plasma breakdown electrode, a drug cabin and a multi-frequency pulse plasma power supply. The plasma breakdown electrode is arranged on one circle of the periphery of the device and used for penetrating the skin to perform deep plasma discharge on the skin, the plasma dosing electrode is connected with the medicine cabin and used for controlling the injection of the medicine, the medicine cabin is used for storing the injected medicine, and the multi-frequency pulse plasma power supply is used for controlling the voltage and the frequency of the plasma generated by the plasma breakdown electrode.
The plasma administration electrode is used for puncturing the epidermis layer and the dermis layer of the skin to open an injection channel of the skin, the plasma breakdown electrode is used for injecting drugs into the channel opened in the plasma administration electrode, the drug cabin is used for storing the injected drugs, and the multi-frequency pulse plasma power supply is used for controlling the plasma breakdown electrode to generate different voltages and plasmas under different application scenes so as to control the breakdown condition of the skin.
The invention adopts a subcutaneous administration device, an injection type pinhole electrode is adopted in one circle of the outer diameter of an injector to pierce a skin epidermal layer till reaching a corium layer, and the absorption of medicine at the local position of a body is promoted by the diffusion of plasma generated by high voltage of the multi-frequency pulse plasma source at the corium layer or a subcutaneous tissue part through the connection of the multi-frequency pulse plasma source at the upper end.
The multi-frequency pulse plasma power supply adopted by the invention can control the intensity of plasma generation by manually adjusting the discharge voltage and frequency of the plasma source according to the position of the subcutaneous drug delivery device to be injected and the drug delivery depth.
Compared with the prior art, the invention has the following advantages:
(1) the invention can effectively relieve the pain perception of subcutaneous injection to human body and reduce the damage during injection;
(2) the invention treats the skin at the injection position through plasma, and can effectively improve the absorption effect of the medicine.
Drawings
FIG. 1 is a side view of a low temperature plasma-based subcutaneous drug delivery device of the present invention;
FIG. 2 is a bottom view of the low temperature plasma-based subcutaneous drug delivery device of the present invention;
FIG. 3 is a first diagram of the plasma breakdown electrode;
FIG. 4 is a second diagram of the action of the plasma administration electrode;
in the figure: 1 is a plasma breakdown electrode, 2 is a plasma administration electrode, 3 is a medicine cabin, and 4 is a multi-frequency pulse plasma power supply.
Detailed Description
The invention is further described with reference to the following figures and detailed description.
The subcutaneous drug delivery device based on low-temperature plasma penetrates deep into skin through a plasma breakdown electrode, and the electrode used for plasma breakdown is small and can reach the micron level, so that human sense can be close to no sense when the subcutaneous drug delivery device is used for subcutaneous injection. The subcutaneous drug delivery device based on low-temperature plasma is composed of a plasma breakdown electrode 1, a plasma drug delivery electrode 2, a drug cabin 3 and a multi-frequency pulse plasma power supply 4. The plasma breakdown electrode 1 is arranged on the periphery of the device in a circle and used for penetrating the skin to perform deep-layer plasma discharge, the plasma administration electrode 2 is connected with the medicine cabin 3 and used for controlling the injection of medicines, the medicine cabin 3 is used for storing the injected medicines, and the multi-frequency pulse plasma power supply 4 is used for controlling the voltage and the frequency of the plasma generated by the plasma breakdown electrode 1. When injecting, its theory of operation is as follows:
1. when medicine is injected to a certain part of a human body, the plasma breakdown electrode 1 firstly pierces the skin layer of the human body to carry out subcutaneous plasma discharge on the skin layer of the human body, and the plasma is generated by high-voltage discharge formed by the multi-frequency pulse plasma power supply 4 to treat the skin. The voltage discharge intensity and frequency of the multi-frequency pulse plasma power supply 4 are controlled according to different human body injections and the property of the medicine, so that the discharge property of the plasma breakdown electrode 1 and the property of the plasma are changed, and the medicine absorption is promoted. As shown in fig. 3.
2. Then, the plasma administration electrode 2 is injected into the skin layer of the human body, the injection of the medicine is carried out in the area activated by the plasma, and the plasma administration electrode 2 is connected with the medicine cabin 3, so that the injection speed of the medicine can be changed by controlling the pressure of the plasma administration electrode 2. As shown in fig. 4.
3. Under the combined action of the plasma breakdown electrode 1 and the plasma administration electrode 2, the subcutaneous administration device based on low-temperature plasma quickly realizes the injection of drugs into human bodies.
Claims (4)
1. A subcutaneous drug delivery device based on low temperature plasma, characterized in that: the device is composed of a plasma breakdown electrode (1), a plasma administration electrode (2), a medicine cabin (3) and a multi-frequency pulse plasma power supply (4), wherein the plasma breakdown electrode (1) is arranged on one circle of the periphery of the device and used for puncturing the skin to perform deep skin plasma discharge, the plasma administration electrode (2) is connected with the medicine cabin (3) and used for controlling injection of medicines, the medicine cabin (3) is used for storing the injected medicines, and the multi-frequency pulse plasma power supply (4) is used for controlling the voltage and the frequency of plasma generated by the plasma breakdown electrode (1).
2. A low temperature plasma-based subcutaneous drug delivery device according to claim 1, wherein: the plasma administration electrode is used for puncturing the epidermis layer and the dermis layer of the skin to open an injection channel of the skin, the plasma breakdown electrode is used for injecting drugs into the channel opened in the plasma administration electrode, the drug cabin is used for storing the injected drugs, and the multi-frequency pulse plasma power supply is used for controlling the plasma breakdown electrode to generate different voltages and plasmas under different application scenes so as to control the breakdown condition of the skin.
3. A low temperature plasma-based subcutaneous drug delivery device according to claim 1, wherein: the subcutaneous administration device is adopted, an injection type pinhole electrode is adopted in one circle of the outer diameter of an injector to pierce the epidermis layer of the skin to the dermis layer, and the absorption of the medicine at the local position of the body is promoted by connecting an upper end multi-frequency pulse plasma source and diffusing the plasma generated by high voltage of the plasma in the dermis layer or subcutaneous tissue.
4. A low temperature plasma-based subcutaneous drug delivery device according to any of claims 1-3, wherein: the adopted multi-frequency pulse plasma power supply can control the intensity of plasma generation by manually adjusting the discharge voltage and frequency of the plasma source according to the position of the subcutaneous drug delivery device to be injected and the drug delivery depth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911076368.5A CN110743099A (en) | 2019-11-06 | 2019-11-06 | Subcutaneous drug delivery device based on low-temperature plasma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911076368.5A CN110743099A (en) | 2019-11-06 | 2019-11-06 | Subcutaneous drug delivery device based on low-temperature plasma |
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| Publication Number | Publication Date |
|---|---|
| CN110743099A true CN110743099A (en) | 2020-02-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911076368.5A Pending CN110743099A (en) | 2019-11-06 | 2019-11-06 | Subcutaneous drug delivery device based on low-temperature plasma |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102137629A (en) * | 2007-01-31 | 2011-07-27 | 阿尔玛雷射公司 | Skin treatment using a multi-discharge applicator |
| CN202637148U (en) * | 2012-06-01 | 2013-01-02 | 华中科技大学同济医学院附属同济医院 | Medicine-carrying plasma needle device |
| CN204147418U (en) * | 2014-03-18 | 2015-02-11 | 苏州壹达生物科技有限公司 | A kind of device utilizing the administration of coreless armature pin electroporation |
| CN105792885A (en) * | 2013-12-04 | 2016-07-20 | Ep科技有限公司 | Transdermal delivery of DNA vaccines using non-thermal plasma |
| CN211751794U (en) * | 2019-11-06 | 2020-10-27 | 中国科学技术大学 | Subcutaneous drug delivery device based on low-temperature plasma |
-
2019
- 2019-11-06 CN CN201911076368.5A patent/CN110743099A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102137629A (en) * | 2007-01-31 | 2011-07-27 | 阿尔玛雷射公司 | Skin treatment using a multi-discharge applicator |
| CN202637148U (en) * | 2012-06-01 | 2013-01-02 | 华中科技大学同济医学院附属同济医院 | Medicine-carrying plasma needle device |
| CN105792885A (en) * | 2013-12-04 | 2016-07-20 | Ep科技有限公司 | Transdermal delivery of DNA vaccines using non-thermal plasma |
| CN204147418U (en) * | 2014-03-18 | 2015-02-11 | 苏州壹达生物科技有限公司 | A kind of device utilizing the administration of coreless armature pin electroporation |
| CN211751794U (en) * | 2019-11-06 | 2020-10-27 | 中国科学技术大学 | Subcutaneous drug delivery device based on low-temperature plasma |
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