CN110743099A - Low-temperature plasma-based subcutaneous drug delivery device - Google Patents
Low-temperature plasma-based subcutaneous drug delivery device Download PDFInfo
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- CN110743099A CN110743099A CN201911076368.5A CN201911076368A CN110743099A CN 110743099 A CN110743099 A CN 110743099A CN 201911076368 A CN201911076368 A CN 201911076368A CN 110743099 A CN110743099 A CN 110743099A
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 33
- 238000007920 subcutaneous administration Methods 0.000 title abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 42
- 229940079593 drug Drugs 0.000 claims abstract description 39
- 210000003491 skin Anatomy 0.000 claims abstract description 33
- 230000015556 catabolic process Effects 0.000 claims abstract description 25
- 238000002347 injection Methods 0.000 claims abstract description 15
- 239000007924 injection Substances 0.000 claims abstract description 15
- 238000010521 absorption reaction Methods 0.000 claims abstract description 8
- 210000004207 dermis Anatomy 0.000 claims abstract description 7
- 210000002615 epidermis Anatomy 0.000 claims abstract description 5
- 230000000694 effects Effects 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000009792 diffusion process Methods 0.000 claims description 2
- 206010033675 panniculitis Diseases 0.000 claims description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 2
- 238000001647 drug administration Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 abstract description 71
- 208000002193 Pain Diseases 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 5
- 238000010254 subcutaneous injection Methods 0.000 abstract description 3
- 239000007929 subcutaneous injection Substances 0.000 abstract description 3
- 230000006378 damage Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000002775 capsule Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000037324 pain perception Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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Abstract
Description
技术领域technical field
本发明涉及皮下给药装置的技术领域,具体涉及一种基于低温等离子体的皮下给药装置。The present invention relates to the technical field of subcutaneous drug delivery devices, in particular to a low temperature plasma-based subcutaneous drug delivery device.
背景技术Background technique
目前对于穿破皮肤表层的给药技术都是基于针头注入的方式,但是针孔注入式的方式因为针孔针头尺寸较大,往往对皮肤造成疼痛及发炎或感染的损伤。而基于低温等离子体的皮下给药装置通过缩小针头的尺寸,采用微小电极针孔的方式注入皮肤,从而减小疼痛感,并减小对人体皮肤组织的损害。此外,通过基于低温等离子体的皮下给药装置可以更好的保证注入药物的药理性,并通过电极对皮肤组织的等离子体放电提高皮肤组织的活跃性,从而更好的达到药物吸收的作用。The current drug delivery techniques for piercing the skin surface are all based on needle injection, but the needle-hole injection method often causes pain, inflammation or infection damage to the skin due to the large size of the needle. The hypodermic drug delivery device based on low temperature plasma reduces the pain and damage to human skin tissue by reducing the size of the needle and injecting it into the skin by means of tiny electrode pinholes. In addition, the subcutaneous drug delivery device based on low temperature plasma can better ensure the pharmacological properties of the injected drug, and improve the activity of the skin tissue through the plasma discharge of the electrode to the skin tissue, so as to better achieve the effect of drug absorption.
发明内容SUMMARY OF THE INVENTION
本发明要解决的技术问题为:目前使用的皮下给药技术都是通过注射式针孔直接刺破皮肤并进行注射,而该技术由于针孔孔径过大会对人体皮肤造成疼痛感,因此本发明通过减小针孔孔径可以减缓人体疼痛感,同时药物注射位置经过等离子体的处理,可以有效提高药物的吸收性。The technical problem to be solved by the present invention is: the currently used subcutaneous administration technology is to directly pierce the skin and inject through the injection needle hole, and this technology causes pain to the human skin due to the large hole diameter of the needle hole, so the present invention The pain of the human body can be alleviated by reducing the diameter of the pinhole, and the absorption of the drug can be effectively improved after the plasma treatment of the drug injection site.
本发明采用的技术方案为:基于低温等离子体的皮下给药装置,由等离子体给药电极、等离子体击穿电极、药物舱、多频脉冲等离子体电源组成。其中等离子体击穿电极在装置的外围一圈,用于刺穿皮肤进行皮肤深层等离子体放电,等离子体给药电极连接药物舱用于控制药物的注入,药物舱用于存放注入药物,多频脉冲等离子体电源用于控制等离子体击穿电极产生等离子体的电压和频率。The technical scheme adopted in the present invention is as follows: a low-temperature plasma-based subcutaneous drug delivery device is composed of a plasma drug delivery electrode, a plasma breakdown electrode, a drug capsule, and a multi-frequency pulse plasma power source. The plasma breakdown electrode is around the periphery of the device, which is used to pierce the skin for deep skin plasma discharge. The plasma dosing electrode is connected to the drug compartment to control the injection of the drug, and the drug compartment is used to store the injected drug. The pulsed plasma power supply is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode.
其中等离子体给药电极用于击穿皮肤的表皮层和真皮层将皮肤的注射通道打开,等离子体击穿电极用于在等离子体给药电极中打开的通道中注入药物,药物舱用于存储注入的药物,多频脉冲等离子体电源用于控制等离子体击穿电极在不同的应用场景下产生不同的电压及等离子体从而控制对皮肤的击穿情况。The plasma dosing electrode is used for penetrating the epidermis and dermis of the skin to open the injection channel of the skin, the plasma penetrating electrode is used for injecting drugs into the channel opened in the plasma dosing electrode, and the drug compartment is used for storage The injected drug and multi-frequency pulsed plasma power supply are used to control the plasma breakdown electrode to generate different voltages and plasmas in different application scenarios to control the breakdown of the skin.
本发明所采用皮下给药装置,在注射器的外径一圈采用注入式针孔电极,刺穿皮肤表皮层,直至真皮层,通过连接上端多频脉冲等离子体源,通过其高压产生的等离子体在真皮层或皮下组织部位的扩散,促进身体局部位置对药物的吸收。The subcutaneous drug delivery device used in the present invention adopts an injection-type pinhole electrode around the outer diameter of the syringe to pierce the epidermis layer of the skin to the dermis layer. By connecting the upper end of the multi-frequency pulse plasma source, the plasma generated by its high voltage is generated. Diffusion in the dermis or subcutaneous tissue promotes the absorption of the drug in local parts of the body.
本发明所采用的多频脉冲等离子体电源可根据皮下给药装置需注射的位置,以及给药的深度,通过手动调节等离子体源的放电电压、频率控制等离子体产生的强度。The multi-frequency pulse plasma power source used in the present invention can control the intensity of plasma generation by manually adjusting the discharge voltage and frequency of the plasma source according to the position where the subcutaneous drug delivery device needs to be injected and the depth of drug delivery.
本发明与现有技术相比的有点在于:The advantages of the present invention compared with the prior art are:
(1)本发明可以有效减缓皮下注入对人体的疼痛感知,降低注射时的伤害;(1) the present invention can effectively slow down the pain perception of subcutaneous injection to the human body, and reduce the injury during injection;
(2)本发明通过等离子对注入位置的皮肤进行处理,可以有效提高药物的吸收作用。(2) In the present invention, the skin at the injection site is treated by plasma, which can effectively improve the absorption of the drug.
附图说明Description of drawings
图1为本发明基于低温等离子体的皮下给药装置侧视图;Fig. 1 is the side view of the hypodermic drug delivery device based on low temperature plasma of the present invention;
图2为本发明基于低温等离子体的皮下给药装置仰视图;Fig. 2 is the bottom view of the hypodermic drug delivery device based on low temperature plasma of the present invention;
图3为等离子体击穿电极作用图一;Fig. 3 is the action diagram 1 of plasma breakdown electrode;
图4为等离子体给药电极作用图二;Fig. 4 is the action diagram 2 of the plasma dosing electrode;
图中:1为等离子体击穿电极,2为等离子体给药电极,3为药物舱,4为多频脉冲等离子体电源。In the figure: 1 is the plasma breakdown electrode, 2 is the plasma administration electrode, 3 is the medicine chamber, and 4 is the multi-frequency pulse plasma power supply.
具体实施方式Detailed ways
下面结合附图以及具体实施方式进一步说明本发明。The present invention will be further described below with reference to the accompanying drawings and specific embodiments.
基于低温等离子体的皮下给药装置,通过等离子体击穿电极刺入皮肤深处,由于等离子体击穿所用的电极及其细小,可至微米级别,因此在皮下注入时可使得人体感官接近无感。基于低温等离子体的皮下给药装置由等离子体击穿电极1、等离子体给药电极2、药物舱3、多频脉冲等离子体电源4组成。其中等离子体击穿电极1在装置的外围一圈,用于刺穿皮肤进行皮肤深层等离子体放电,等离子体给药电极2连接药物舱3用于控制药物的注入,药物舱3用于存放注入药物,多频脉冲等离子体电源4用于控制等离子体击穿电极1产生等离子体的电压和频率。在注入时,其其工作原理如下:The hypodermic drug delivery device based on low temperature plasma penetrates deep into the skin through the plasma breakdown electrode. Since the electrode used for plasma breakdown is so small that it can reach the micron level, the subcutaneous injection can make the human senses close to zero. sense. The subcutaneous drug delivery device based on low temperature plasma is composed of
1.当对人体某部位进行药物注射时,等离子体击穿电极1首先刺穿人体皮肤层在人体皮肤层进行皮下等离子体放电,通过多频脉冲等离子体电源4形成高压放电产生等离子体对皮肤进行处理,由于等离子体可以对注入皮肤位置进行刺激,促进皮肤中细胞的活跃因此可以提高药物被人体的吸收程度。针对人体注入的不同以及药物的属性,控制多频脉冲等离子体电源4的电压放电强度以及频率,从而改变等离子体击穿电极1放电属性以及等离子体的属性,促进药物的吸收。如图3所示。1. When injecting drugs into a certain part of the human body, the
2.然后,等离子体给药电极2注入人体皮肤层,在被等离子体活化的区域进行药物的注入,其连接药物舱3,可供过控制等离子体给药电极2控制压力的大小改变药物注入的速度。如图4所示。2. Then, the plasma
3.在等离子体击穿电极1、等离子体给药电极2的共同作用下,基于低温等离子体的皮下给药装置迅速实现对人体的药物注入。3. Under the combined action of the
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102137629A (en) * | 2007-01-31 | 2011-07-27 | 阿尔玛雷射公司 | Skin treatment using a multi-discharge applicator |
CN202637148U (en) * | 2012-06-01 | 2013-01-02 | 华中科技大学同济医学院附属同济医院 | Medicine-carrying plasma needle device |
CN204147418U (en) * | 2014-03-18 | 2015-02-11 | 苏州壹达生物科技有限公司 | A kind of device utilizing the administration of coreless armature pin electroporation |
CN105792885A (en) * | 2013-12-04 | 2016-07-20 | Ep科技有限公司 | Transdermal delivery of DNA vaccines using non-thermal plasma |
CN211751794U (en) * | 2019-11-06 | 2020-10-27 | 中国科学技术大学 | Subcutaneous drug delivery device based on low-temperature plasma |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102137629A (en) * | 2007-01-31 | 2011-07-27 | 阿尔玛雷射公司 | Skin treatment using a multi-discharge applicator |
CN202637148U (en) * | 2012-06-01 | 2013-01-02 | 华中科技大学同济医学院附属同济医院 | Medicine-carrying plasma needle device |
CN105792885A (en) * | 2013-12-04 | 2016-07-20 | Ep科技有限公司 | Transdermal delivery of DNA vaccines using non-thermal plasma |
CN204147418U (en) * | 2014-03-18 | 2015-02-11 | 苏州壹达生物科技有限公司 | A kind of device utilizing the administration of coreless armature pin electroporation |
CN211751794U (en) * | 2019-11-06 | 2020-10-27 | 中国科学技术大学 | Subcutaneous drug delivery device based on low-temperature plasma |
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