CN110743099A - Low-temperature plasma-based subcutaneous drug delivery device - Google Patents

Low-temperature plasma-based subcutaneous drug delivery device Download PDF

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CN110743099A
CN110743099A CN201911076368.5A CN201911076368A CN110743099A CN 110743099 A CN110743099 A CN 110743099A CN 201911076368 A CN201911076368 A CN 201911076368A CN 110743099 A CN110743099 A CN 110743099A
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plasma
electrode
drug delivery
drug
skin
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吴征威
王琨
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University of Science and Technology of China USTC
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University of Science and Technology of China USTC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

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  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses a subcutaneous drug delivery device based on low-temperature plasma, which consists of a plasma drug delivery electrode, a plasma breakdown electrode, a drug cabin and a multi-frequency pulse plasma power supply. The plasma administration electrode is used for puncturing the epidermis layer and the dermis layer of the skin to open an injection channel of the skin, the plasma breakdown electrode is used for injecting drugs into the channel opened in the plasma administration electrode, the drug cabin is used for storing the injected drugs, and the multi-frequency pulse plasma power supply is used for controlling the plasma breakdown electrode to generate different voltages and plasmas under different application scenes so as to control the breakdown condition of the skin. By using the subcutaneous drug delivery device based on low-temperature plasma disclosed by the invention, the pain of a human body on subcutaneous injection drug delivery can be relieved, and the effective absorption of drugs in the human body is improved.

Description

基于低温等离子体的皮下给药装置Low-temperature plasma-based subcutaneous drug delivery device

技术领域technical field

本发明涉及皮下给药装置的技术领域,具体涉及一种基于低温等离子体的皮下给药装置。The present invention relates to the technical field of subcutaneous drug delivery devices, in particular to a low temperature plasma-based subcutaneous drug delivery device.

背景技术Background technique

目前对于穿破皮肤表层的给药技术都是基于针头注入的方式,但是针孔注入式的方式因为针孔针头尺寸较大,往往对皮肤造成疼痛及发炎或感染的损伤。而基于低温等离子体的皮下给药装置通过缩小针头的尺寸,采用微小电极针孔的方式注入皮肤,从而减小疼痛感,并减小对人体皮肤组织的损害。此外,通过基于低温等离子体的皮下给药装置可以更好的保证注入药物的药理性,并通过电极对皮肤组织的等离子体放电提高皮肤组织的活跃性,从而更好的达到药物吸收的作用。The current drug delivery techniques for piercing the skin surface are all based on needle injection, but the needle-hole injection method often causes pain, inflammation or infection damage to the skin due to the large size of the needle. The hypodermic drug delivery device based on low temperature plasma reduces the pain and damage to human skin tissue by reducing the size of the needle and injecting it into the skin by means of tiny electrode pinholes. In addition, the subcutaneous drug delivery device based on low temperature plasma can better ensure the pharmacological properties of the injected drug, and improve the activity of the skin tissue through the plasma discharge of the electrode to the skin tissue, so as to better achieve the effect of drug absorption.

发明内容SUMMARY OF THE INVENTION

本发明要解决的技术问题为:目前使用的皮下给药技术都是通过注射式针孔直接刺破皮肤并进行注射,而该技术由于针孔孔径过大会对人体皮肤造成疼痛感,因此本发明通过减小针孔孔径可以减缓人体疼痛感,同时药物注射位置经过等离子体的处理,可以有效提高药物的吸收性。The technical problem to be solved by the present invention is: the currently used subcutaneous administration technology is to directly pierce the skin and inject through the injection needle hole, and this technology causes pain to the human skin due to the large hole diameter of the needle hole, so the present invention The pain of the human body can be alleviated by reducing the diameter of the pinhole, and the absorption of the drug can be effectively improved after the plasma treatment of the drug injection site.

本发明采用的技术方案为:基于低温等离子体的皮下给药装置,由等离子体给药电极、等离子体击穿电极、药物舱、多频脉冲等离子体电源组成。其中等离子体击穿电极在装置的外围一圈,用于刺穿皮肤进行皮肤深层等离子体放电,等离子体给药电极连接药物舱用于控制药物的注入,药物舱用于存放注入药物,多频脉冲等离子体电源用于控制等离子体击穿电极产生等离子体的电压和频率。The technical scheme adopted in the present invention is as follows: a low-temperature plasma-based subcutaneous drug delivery device is composed of a plasma drug delivery electrode, a plasma breakdown electrode, a drug capsule, and a multi-frequency pulse plasma power source. The plasma breakdown electrode is around the periphery of the device, which is used to pierce the skin for deep skin plasma discharge. The plasma dosing electrode is connected to the drug compartment to control the injection of the drug, and the drug compartment is used to store the injected drug. The pulsed plasma power supply is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode.

其中等离子体给药电极用于击穿皮肤的表皮层和真皮层将皮肤的注射通道打开,等离子体击穿电极用于在等离子体给药电极中打开的通道中注入药物,药物舱用于存储注入的药物,多频脉冲等离子体电源用于控制等离子体击穿电极在不同的应用场景下产生不同的电压及等离子体从而控制对皮肤的击穿情况。The plasma dosing electrode is used for penetrating the epidermis and dermis of the skin to open the injection channel of the skin, the plasma penetrating electrode is used for injecting drugs into the channel opened in the plasma dosing electrode, and the drug compartment is used for storage The injected drug and multi-frequency pulsed plasma power supply are used to control the plasma breakdown electrode to generate different voltages and plasmas in different application scenarios to control the breakdown of the skin.

本发明所采用皮下给药装置,在注射器的外径一圈采用注入式针孔电极,刺穿皮肤表皮层,直至真皮层,通过连接上端多频脉冲等离子体源,通过其高压产生的等离子体在真皮层或皮下组织部位的扩散,促进身体局部位置对药物的吸收。The subcutaneous drug delivery device used in the present invention adopts an injection-type pinhole electrode around the outer diameter of the syringe to pierce the epidermis layer of the skin to the dermis layer. By connecting the upper end of the multi-frequency pulse plasma source, the plasma generated by its high voltage is generated. Diffusion in the dermis or subcutaneous tissue promotes the absorption of the drug in local parts of the body.

本发明所采用的多频脉冲等离子体电源可根据皮下给药装置需注射的位置,以及给药的深度,通过手动调节等离子体源的放电电压、频率控制等离子体产生的强度。The multi-frequency pulse plasma power source used in the present invention can control the intensity of plasma generation by manually adjusting the discharge voltage and frequency of the plasma source according to the position where the subcutaneous drug delivery device needs to be injected and the depth of drug delivery.

本发明与现有技术相比的有点在于:The advantages of the present invention compared with the prior art are:

(1)本发明可以有效减缓皮下注入对人体的疼痛感知,降低注射时的伤害;(1) the present invention can effectively slow down the pain perception of subcutaneous injection to the human body, and reduce the injury during injection;

(2)本发明通过等离子对注入位置的皮肤进行处理,可以有效提高药物的吸收作用。(2) In the present invention, the skin at the injection site is treated by plasma, which can effectively improve the absorption of the drug.

附图说明Description of drawings

图1为本发明基于低温等离子体的皮下给药装置侧视图;Fig. 1 is the side view of the hypodermic drug delivery device based on low temperature plasma of the present invention;

图2为本发明基于低温等离子体的皮下给药装置仰视图;Fig. 2 is the bottom view of the hypodermic drug delivery device based on low temperature plasma of the present invention;

图3为等离子体击穿电极作用图一;Fig. 3 is the action diagram 1 of plasma breakdown electrode;

图4为等离子体给药电极作用图二;Fig. 4 is the action diagram 2 of the plasma dosing electrode;

图中:1为等离子体击穿电极,2为等离子体给药电极,3为药物舱,4为多频脉冲等离子体电源。In the figure: 1 is the plasma breakdown electrode, 2 is the plasma administration electrode, 3 is the medicine chamber, and 4 is the multi-frequency pulse plasma power supply.

具体实施方式Detailed ways

下面结合附图以及具体实施方式进一步说明本发明。The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

基于低温等离子体的皮下给药装置,通过等离子体击穿电极刺入皮肤深处,由于等离子体击穿所用的电极及其细小,可至微米级别,因此在皮下注入时可使得人体感官接近无感。基于低温等离子体的皮下给药装置由等离子体击穿电极1、等离子体给药电极2、药物舱3、多频脉冲等离子体电源4组成。其中等离子体击穿电极1在装置的外围一圈,用于刺穿皮肤进行皮肤深层等离子体放电,等离子体给药电极2连接药物舱3用于控制药物的注入,药物舱3用于存放注入药物,多频脉冲等离子体电源4用于控制等离子体击穿电极1产生等离子体的电压和频率。在注入时,其其工作原理如下:The hypodermic drug delivery device based on low temperature plasma penetrates deep into the skin through the plasma breakdown electrode. Since the electrode used for plasma breakdown is so small that it can reach the micron level, the subcutaneous injection can make the human senses close to zero. sense. The subcutaneous drug delivery device based on low temperature plasma is composed of plasma breakdown electrode 1 , plasma drug delivery electrode 2 , drug capsule 3 , and multi-frequency pulse plasma power source 4 . The plasma breakdown electrode 1 is around the periphery of the device, which is used to pierce the skin for deep skin plasma discharge. The plasma dosing electrode 2 is connected to the drug compartment 3 to control the injection of the drug, and the drug compartment 3 is used to store the injection. The drug, the multi-frequency pulse plasma power source 4 is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode 1 . When injected, it works as follows:

1.当对人体某部位进行药物注射时,等离子体击穿电极1首先刺穿人体皮肤层在人体皮肤层进行皮下等离子体放电,通过多频脉冲等离子体电源4形成高压放电产生等离子体对皮肤进行处理,由于等离子体可以对注入皮肤位置进行刺激,促进皮肤中细胞的活跃因此可以提高药物被人体的吸收程度。针对人体注入的不同以及药物的属性,控制多频脉冲等离子体电源4的电压放电强度以及频率,从而改变等离子体击穿电极1放电属性以及等离子体的属性,促进药物的吸收。如图3所示。1. When injecting drugs into a certain part of the human body, the plasma breakdown electrode 1 first pierces the human skin layer to perform subcutaneous plasma discharge in the human skin layer, and generates a high-voltage discharge through the multi-frequency pulse plasma power supply 4 to generate plasma on the skin. For treatment, since the plasma can stimulate the injection site of the skin and promote the activity of cells in the skin, it can improve the absorption of the drug by the human body. According to the difference of human injection and the properties of drugs, the voltage discharge intensity and frequency of the multi-frequency pulse plasma power supply 4 are controlled, so as to change the discharge properties of the plasma breakdown electrode 1 and the properties of the plasma, and promote the absorption of drugs. As shown in Figure 3.

2.然后,等离子体给药电极2注入人体皮肤层,在被等离子体活化的区域进行药物的注入,其连接药物舱3,可供过控制等离子体给药电极2控制压力的大小改变药物注入的速度。如图4所示。2. Then, the plasma drug delivery electrode 2 is injected into the human skin layer, and the drug is injected in the area activated by the plasma, which is connected to the drug compartment 3, which can be used to control the pressure of the plasma drug delivery electrode 2 to change the drug injection. speed. As shown in Figure 4.

3.在等离子体击穿电极1、等离子体给药电极2的共同作用下,基于低温等离子体的皮下给药装置迅速实现对人体的药物注入。3. Under the combined action of the plasma breakdown electrode 1 and the plasma drug delivery electrode 2, the low-temperature plasma-based subcutaneous drug delivery device can rapidly inject drugs into the human body.

Claims (4)

1.一种基于低温等离子体的皮下给药装置,其特征在于:由等离子体击穿电极(1)、等离子体给药电极(2)、药物舱(3)、多频脉冲等离子体电源(4)组成,其中等离子体击穿电极(1)在装置的外围一圈,用于刺穿皮肤进行皮肤深层等离子体放电,等离子体给药电极(2)连接药物舱(3)用于控制药物的注入,药物舱(3)用于存放注入药物,多频脉冲等离子体电源(4)用于控制等离子体击穿电极(1)产生等离子体的电压和频率。1. A hypodermic drug delivery device based on low temperature plasma, characterized in that: a plasma breakdown electrode (1), a plasma drug delivery electrode (2), a drug compartment (3), a multi-frequency pulse plasma power supply ( 4) composition, wherein the plasma breakdown electrode (1) is around the periphery of the device for piercing the skin for deep skin plasma discharge, and the plasma drug delivery electrode (2) is connected to the drug compartment (3) for controlling the drug The medicine compartment (3) is used to store the injected medicine, and the multi-frequency pulse plasma power supply (4) is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode (1). 2.根据权利要求1所述的一种基于低温等离子体的皮下给药装置,其特征在于:等离子体给药电极用于击穿皮肤的表皮层和真皮层将皮肤的注射通道打开,等离子体击穿电极用于在等离子体给药电极中打开的通道中注入药物,药物舱用于存储注入的药物,多频脉冲等离子体电源用于控制等离子体击穿电极在不同的应用场景下产生不同的电压及等离子体从而控制对皮肤的击穿情况。2 . A low-temperature plasma-based hypodermic drug delivery device according to claim 1 , wherein the plasma drug delivery electrode is used for penetrating the epidermis and dermis of the skin to open the injection channel of the skin, 2 . The breakdown electrode is used to inject the drug into the channel opened in the plasma dosing electrode, the drug compartment is used to store the injected drug, and the multi-frequency pulsed plasma power supply is used to control the plasma breakdown electrode to produce different effects in different application scenarios. voltage and plasma to control the breakdown of the skin. 3.根据权利要求1所述的一种基于低温等离子体的皮下给药装置,其特征在于:采用皮下给药装置,在注射器的外径一圈采用注入式针孔电极,刺穿皮肤表皮层,直至真皮层,通过连接上端多频脉冲等离子体源,通过其高压产生的等离子体在真皮层或皮下组织部位的扩散,促进身体局部位置对药物的吸收。3. A low-temperature plasma-based hypodermic drug delivery device according to claim 1, characterized in that: a hypodermic drug delivery device is used, and an injection-type pinhole electrode is used around the outer diameter of the syringe to pierce the epidermis of the skin , until the dermis layer, by connecting the upper end of the multi-frequency pulse plasma source, through the diffusion of the plasma generated by its high pressure in the dermis layer or subcutaneous tissue, it can promote the absorption of drugs in local parts of the body. 4.根据权利要求1-3任一项所述的一种基于低温等离子体的皮下给药装置,其特征在于:采用的多频脉冲等离子体电源可根据皮下给药装置需注射的位置,以及给药的深度,通过手动调节等离子体源的放电电压、频率控制等离子体产生的强度。4. A low-temperature plasma-based hypodermic drug delivery device according to any one of claims 1 to 3, wherein the multi-frequency pulsed plasma power used can be injected according to the position of the hypodermic drug delivery device, and The depth of drug administration is controlled by manually adjusting the discharge voltage and frequency of the plasma source to control the intensity of plasma generation.
CN201911076368.5A 2019-11-06 2019-11-06 Low-temperature plasma-based subcutaneous drug delivery device Pending CN110743099A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102137629A (en) * 2007-01-31 2011-07-27 阿尔玛雷射公司 Skin treatment using a multi-discharge applicator
CN202637148U (en) * 2012-06-01 2013-01-02 华中科技大学同济医学院附属同济医院 Medicine-carrying plasma needle device
CN204147418U (en) * 2014-03-18 2015-02-11 苏州壹达生物科技有限公司 A kind of device utilizing the administration of coreless armature pin electroporation
CN105792885A (en) * 2013-12-04 2016-07-20 Ep科技有限公司 Transdermal delivery of DNA vaccines using non-thermal plasma
CN211751794U (en) * 2019-11-06 2020-10-27 中国科学技术大学 Subcutaneous drug delivery device based on low-temperature plasma

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102137629A (en) * 2007-01-31 2011-07-27 阿尔玛雷射公司 Skin treatment using a multi-discharge applicator
CN202637148U (en) * 2012-06-01 2013-01-02 华中科技大学同济医学院附属同济医院 Medicine-carrying plasma needle device
CN105792885A (en) * 2013-12-04 2016-07-20 Ep科技有限公司 Transdermal delivery of DNA vaccines using non-thermal plasma
CN204147418U (en) * 2014-03-18 2015-02-11 苏州壹达生物科技有限公司 A kind of device utilizing the administration of coreless armature pin electroporation
CN211751794U (en) * 2019-11-06 2020-10-27 中国科学技术大学 Subcutaneous drug delivery device based on low-temperature plasma

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