CN110743099A - Low-temperature plasma-based subcutaneous drug delivery device - Google Patents

Abstract

The invention discloses a subcutaneous drug delivery device based on low-temperature plasma, which consists of a plasma drug delivery electrode, a plasma breakdown electrode, a drug cabin and a multi-frequency pulse plasma power supply. The plasma administration electrode is used for puncturing the epidermis layer and the dermis layer of the skin to open an injection channel of the skin, the plasma breakdown electrode is used for injecting drugs into the channel opened in the plasma administration electrode, the drug cabin is used for storing the injected drugs, and the multi-frequency pulse plasma power supply is used for controlling the plasma breakdown electrode to generate different voltages and plasmas under different application scenes so as to control the breakdown condition of the skin. By using the subcutaneous drug delivery device based on low-temperature plasma disclosed by the invention, the pain of a human body on subcutaneous injection drug delivery can be relieved, and the effective absorption of drugs in the human body is improved.

Description

Low-temperature plasma-based subcutaneous drug delivery device

technical field

The present invention relates to the technical field of subcutaneous drug delivery devices, in particular to a low temperature plasma-based subcutaneous drug delivery device.

Background technique

The current drug delivery techniques for piercing the skin surface are all based on needle injection, but the needle-hole injection method often causes pain, inflammation or infection damage to the skin due to the large size of the needle. The hypodermic drug delivery device based on low temperature plasma reduces the pain and damage to human skin tissue by reducing the size of the needle and injecting it into the skin by means of tiny electrode pinholes. In addition, the subcutaneous drug delivery device based on low temperature plasma can better ensure the pharmacological properties of the injected drug, and improve the activity of the skin tissue through the plasma discharge of the electrode to the skin tissue, so as to better achieve the effect of drug absorption.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is: the currently used subcutaneous administration technology is to directly pierce the skin and inject through the injection needle hole, and this technology causes pain to the human skin due to the large hole diameter of the needle hole, so the present invention The pain of the human body can be alleviated by reducing the diameter of the pinhole, and the absorption of the drug can be effectively improved after the plasma treatment of the drug injection site.

The technical scheme adopted in the present invention is as follows: a low-temperature plasma-based subcutaneous drug delivery device is composed of a plasma drug delivery electrode, a plasma breakdown electrode, a drug capsule, and a multi-frequency pulse plasma power source. The plasma breakdown electrode is around the periphery of the device, which is used to pierce the skin for deep skin plasma discharge. The plasma dosing electrode is connected to the drug compartment to control the injection of the drug, and the drug compartment is used to store the injected drug. The pulsed plasma power supply is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode.

The plasma dosing electrode is used for penetrating the epidermis and dermis of the skin to open the injection channel of the skin, the plasma penetrating electrode is used for injecting drugs into the channel opened in the plasma dosing electrode, and the drug compartment is used for storage The injected drug and multi-frequency pulsed plasma power supply are used to control the plasma breakdown electrode to generate different voltages and plasmas in different application scenarios to control the breakdown of the skin.

The subcutaneous drug delivery device used in the present invention adopts an injection-type pinhole electrode around the outer diameter of the syringe to pierce the epidermis layer of the skin to the dermis layer. By connecting the upper end of the multi-frequency pulse plasma source, the plasma generated by its high voltage is generated. Diffusion in the dermis or subcutaneous tissue promotes the absorption of the drug in local parts of the body.

The multi-frequency pulse plasma power source used in the present invention can control the intensity of plasma generation by manually adjusting the discharge voltage and frequency of the plasma source according to the position where the subcutaneous drug delivery device needs to be injected and the depth of drug delivery.

The advantages of the present invention compared with the prior art are:

(1) the present invention can effectively slow down the pain perception of subcutaneous injection to the human body, and reduce the injury during injection;

(2) In the present invention, the skin at the injection site is treated by plasma, which can effectively improve the absorption of the drug.

Description of drawings

Fig. 1 is the side view of the hypodermic drug delivery device based on low temperature plasma of the present invention;

Fig. 2 is the bottom view of the hypodermic drug delivery device based on low temperature plasma of the present invention;

Fig. 3 is the action diagram 1 of plasma breakdown electrode;

Fig. 4 is the action diagram 2 of the plasma dosing electrode;

In the figure: 1 is the plasma breakdown electrode, 2 is the plasma administration electrode, 3 is the medicine chamber, and 4 is the multi-frequency pulse plasma power supply.

Detailed ways

The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

The hypodermic drug delivery device based on low temperature plasma penetrates deep into the skin through the plasma breakdown electrode. Since the electrode used for plasma breakdown is so small that it can reach the micron level, the subcutaneous injection can make the human senses close to zero. sense. The subcutaneous drug delivery device based on low temperature plasma is composed of plasma breakdown electrode 1 , plasma drug delivery electrode 2 , drug capsule 3 , and multi-frequency pulse plasma power source 4 . The plasma breakdown electrode 1 is around the periphery of the device, which is used to pierce the skin for deep skin plasma discharge. The plasma dosing electrode 2 is connected to the drug compartment 3 to control the injection of the drug, and the drug compartment 3 is used to store the injection. The drug, the multi-frequency pulse plasma power source 4 is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode 1 . When injected, it works as follows:

1. When injecting drugs into a certain part of the human body, the plasma breakdown electrode 1 first pierces the human skin layer to perform subcutaneous plasma discharge in the human skin layer, and generates a high-voltage discharge through the multi-frequency pulse plasma power supply 4 to generate plasma on the skin. For treatment, since the plasma can stimulate the injection site of the skin and promote the activity of cells in the skin, it can improve the absorption of the drug by the human body. According to the difference of human injection and the properties of drugs, the voltage discharge intensity and frequency of the multi-frequency pulse plasma power supply 4 are controlled, so as to change the discharge properties of the plasma breakdown electrode 1 and the properties of the plasma, and promote the absorption of drugs. As shown in Figure 3.

2. Then, the plasma drug delivery electrode 2 is injected into the human skin layer, and the drug is injected in the area activated by the plasma, which is connected to the drug compartment 3, which can be used to control the pressure of the plasma drug delivery electrode 2 to change the drug injection. speed. As shown in Figure 4.

3. Under the combined action of the plasma breakdown electrode 1 and the plasma drug delivery electrode 2, the low-temperature plasma-based subcutaneous drug delivery device can rapidly inject drugs into the human body.

Claims (4)

1. A hypodermic drug delivery device based on low temperature plasma, characterized in that: a plasma breakdown electrode (1), a plasma drug delivery electrode (2), a drug compartment (3), a multi-frequency pulse plasma power supply ( 4) composition, wherein the plasma breakdown electrode (1) is around the periphery of the device for piercing the skin for deep skin plasma discharge, and the plasma drug delivery electrode (2) is connected to the drug compartment (3) for controlling the drug The medicine compartment (3) is used to store the injected medicine, and the multi-frequency pulse plasma power supply (4) is used to control the voltage and frequency of the plasma generated by the plasma breakdown electrode (1). 2 . A low-temperature plasma-based hypodermic drug delivery device according to claim 1 , wherein the plasma drug delivery electrode is used for penetrating the epidermis and dermis of the skin to open the injection channel of the skin, 2 . The breakdown electrode is used to inject the drug into the channel opened in the plasma dosing electrode, the drug compartment is used to store the injected drug, and the multi-frequency pulsed plasma power supply is used to control the plasma breakdown electrode to produce different effects in different application scenarios. voltage and plasma to control the breakdown of the skin. 3. A low-temperature plasma-based hypodermic drug delivery device according to claim 1, characterized in that: a hypodermic drug delivery device is used, and an injection-type pinhole electrode is used around the outer diameter of the syringe to pierce the epidermis of the skin , until the dermis layer, by connecting the upper end of the multi-frequency pulse plasma source, through the diffusion of the plasma generated by its high pressure in the dermis layer or subcutaneous tissue, it can promote the absorption of drugs in local parts of the body. 4. A low-temperature plasma-based hypodermic drug delivery device according to any one of claims 1 to 3, wherein the multi-frequency pulsed plasma power used can be injected according to the position of the hypodermic drug delivery device, and The depth of drug administration is controlled by manually adjusting the discharge voltage and frequency of the plasma source to control the intensity of plasma generation.

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