CN106063971A - Percutaneous electric osmose doser based on metal porous microneedle array and medication - Google Patents
Percutaneous electric osmose doser based on metal porous microneedle array and medication Download PDFInfo
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- CN106063971A CN106063971A CN201610353146.3A CN201610353146A CN106063971A CN 106063971 A CN106063971 A CN 106063971A CN 201610353146 A CN201610353146 A CN 201610353146A CN 106063971 A CN106063971 A CN 106063971A
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- 229910052751 metal Inorganic materials 0.000 title claims abstract description 84
- 239000002184 metal Substances 0.000 title claims abstract description 84
- 239000003814 drug Substances 0.000 title claims abstract description 50
- 229940079593 drug Drugs 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 238000003466 welding Methods 0.000 claims abstract description 12
- 239000000758 substrate Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 4
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- 239000004332 silver Substances 0.000 claims description 4
- 238000005245 sintering Methods 0.000 claims description 3
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- 238000005660 chlorination reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 230000005684 electric field Effects 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 22
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- 238000001647 drug administration Methods 0.000 description 3
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- 230000033228 biological regulation Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000003187 Juncus effusus Species 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
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- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention relates to a kind of percutaneous electric osmose doser based on metal porous microneedle array and medication, in device, metal porous microneedle array one is connected by welding manner with the anode of medical physiological electrode, metal porous microneedle array two is connected by welding manner with the negative electrode of medical physiological electrode, metal porous microneedle array one is not attached to metal porous microneedle array two, the anode of medical physiological electrode is corresponding with controllable pulse power supply respectively with negative electrode to connect, the present invention utilizes microneedle array to penetrate the cuticular organizational structure of skin disruption, administration channel is provided for liquid medicine subsequently by the duct of metal porous microneedle array, finally it is energized at microneedle array two ends, the effect utilizing electric field and EOF makes drug osmotic enter human body.
Description
Technical field
The present invention relates to biomedical engineering technology field, more specifically, relate to a kind of based on metal porous microneedle array
Percutaneous electric osmose doser and percutaneous electric osmose medication based on metal porous microneedle array.
Background technology
Along with the development of society, the raising of scientific and technological level, medical treatment and health problem are by the weight of increasing people
Depending on.In the treatment means of present stage, pharmaceutical treatment is modal therapeutic modality.Its treatment principle is by certain defeated
Fortune mode, produces drug effect by medicine the most afterwards from external transfer.
Drug administration by injection is the most direct administering mode in pharmaceutical treatment, but injection is administered to the misery meeting that patient brings
The carrying out of impact treatment, drug administration by injection is unable to reach the effect of slow release simultaneously, and blood drug concentration can be caused in the short time quick
Raising, utilization ratio of drug is low, and this is accomplished by the treatment of doctor's frequent drug administration, and this efficiency that not only have impact on treatment can cause trouble simultaneously
The misery that person is bigger.
Percutaneous dosing has prominent advantage, is possible not only to avoid the administration process of complexity, and medicine has very in vivo
High utilization ratio of drug.Because percutaneous dosing enters human circulation through skin by capillary absorbance, so it
Avoid the gastrointestinal tract endoenzyme enzymolysis to it and " first pass effect " of liver, by controlling the speed of percutaneous dosing release medicine
Rate, can make medicine deposit in blood with constant concentration in a long time, reduces the secondary work of medicine to a certain extent
With, enhance drug effect.Therefore, percutaneous dosing is paid close attention to by a lot of preparation scholars both at home and abroad now.
During percutaneous dosing, due to cuticular inhibition so that major part medicine is difficult to directly penetrate into
Enter skin.Therefore the barrier action overcoming cutin is the key improving percutaneous dosing speed.It is used for overcoming cuticular barrier to make
Technology become percutaneous promote saturating technology.The saturating technology of the most common rush mainly include iontophoresis, iontophoresis, magnetic field and
Electrophoresis and hole forming technology, such as methods such as electroporation, hot piercing technology, micropin pore, laser leading-in techniques.Micropin hole forming technology
Belonging to physics hole fabrication techniques, it passes through the micropin puncture effect to skin, penetrates the horny layer of epidermal area and destroys its structure, but not
Tissue and the nerve of skin corium can be penetrated into.Therefore there are the advantages such as hypodynia, wound heal well, and destructiveness is little.Make simultaneously
Make technique relatively easy, have the potentiality that low cost is produced in enormous quantities, so the development prospect of micropin hole forming technology is the most considerable.
Although microneedle array percutaneous dosing technology has good prospect, but microneedle array percutaneous dosing technology is the most not
Maturation, this is the manufacturing process by microneedle array and structure decision itself.Common microneedle array can be divided into solid needle and
Hollow needle, solid needle has good mechanical property, can carry out the puncture of skin, but due to the restriction of this body structure,
Smearing medicine and be administered after needing to puncture in administration process, not only operation is complicated but also medicine-feeding rate is uncontrollable.Hollow
Pin can carry out microneedle injection administration, but mechanical property shows slightly not enough.In recent years, warp was given again in the proposition of degradable micropin concept
Skin is administered and proposes new thinking, and degradable micropin can independently be degraded in administration process can load more medicine simultaneously
Thing, but the not enough and uncontrollable medicine controlled releasing speed of mechanical property remains the difficulty that present stage scientific research personnel needs to overcome
Topic.
Summary of the invention
Present invention aim to overcome that prior art is not enough, it is provided that a kind of percutaneous electric osmose based on metal porous microneedle array
Doser and percutaneous electric osmose medication.Metal porous microneedle array of the present invention has loose structure, for liquid
Medicine provides storage area and administration channel；The most metal porous microneedle array has good mechanical property and mechanical strength,
Significant change is there is not in the pattern of guarantee fund's genus polyporus microneedle array in administration process；Material owing to choosing is bio-compatible
The metal material that property is good, therefore will not cause immunological rejection to human body during skin penetrating；Finally utilize controlled
Metal porous microneedle array two ends are energized by the pulse power, by regulating the size of electric current, control medicine-feeding rate
System, reaches the effect of controlled release.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is:
Percutaneous electric osmose doser based on metal porous microneedle array, including two metal porous microneedle arrays, medical
Physiological electrode and controllable pulse power supply, metal porous microneedle array one passes through welding manner with the anode of described medical physiological electrode
Being connected, metal porous microneedle array two is connected by welding manner with the negative electrode of described medical physiological electrode, described metal porous
Microneedle array one is not attached to described metal porous microneedle array two, the anode of described medical physiological electrode and negative electrode respectively with institute
State controllable pulse power supply correspondence to connect.
The present invention utilizes the duct of metal micro-needle array and conductive characteristic that medicine can carry out microneedle array percutaneous simultaneously
Electric osmose is administered, simple to operate, simplifies dosing step, and the current parameters by regulation controllable pulse power supply can be to medicine-feeding rate
Regulate and control, make percutaneous electric osmose be administered and there is controllability.The hole of microneedle array can be that liquid medicine provides medicine to stay simultaneously
Storehouse, bigger aperture can allow macromolecular drug pass through, and makes microneedle array percutaneous dosing have higher efficiency.The most whole
Individual device has good biocompatibility, will not cause too much injury to human body in administration process, and site of puncture can be
Spontaneous recovery is carried out in short time.
Metal porous microneedle array is formed by the way of metal sintering, selects the metal of good biocompatibility as micropin
The raw material of array, it is to avoid microneedle array is in the contact process of skin to produce immunological rejection, it is preferred that metal porous
Microneedle array material can be titanium alloy.
Metal porous microneedle array shape size is determined by the size of reverse mould microneedle array.For guarantee fund's genus polyporus micropin
Array both can puncture entrance skin histology, can bring more major injury to people again, and loose structure carries for medicine again simultaneously
For route of administration, the substrate thickness of metal porous microneedle array is 3～15mm, and micropin height is 300～600um, tip height
Being 30～80um, the distance between pin and pin is 2～5mm.
The material of medical physiological electrode is silver or silver chloride, and being shaped as of medical physiological electrode is square or circular.
The current signal of controllable pulse power supply is pulse signal, and current intensity is 0.5mA, and waveform is square wave, and frequency is
50HZ, conduction time is 10min.
The present invention also provides for a kind of percutaneous electric osmose medication based on metal porous microneedle array, metal porous micropin battle array
Row one are connected by welding manner with the anode of medical physiological electrode, metal porous microneedle array two and the moon of medical physiological electrode
Pole is connected by welding manner, and described metal porous microneedle array one is not attached to described metal porous microneedle array two, described
The anode of medical physiological electrode is corresponding with controllable pulse power supply respectively with negative electrode to connect, the needle point of described metal porous microneedle array
Prestore liquid medicine, and liquid medicine dropwise instills the mistake of the backside of substrate of described metal porous microneedle array at employing syringe
Cheng Zhong, described controllable pulse power initiation, carry out electric osmose administration, administration process regulates the electric current of described controllable pulse power supply
Medicine-feeding rate is regulated and controled by parameter.
Present invention percutaneous based on metal porous microneedle array electric osmose medication, utilizes the hole of metal porous microneedle array
Hole stores liquid medicine, and provides administration channel at administration process for it, ensures that drug substance stable is continuable during whole
Enter internal.Utilize controllable pulse power supply to control microneedle array needle voltage simultaneously, and then control the speed being administered, make to treat
Journey becomes more efficient.The method medicine-feeding rate is controlled, and dosage can regulate according to Treatment need, did not resulted in human body
Many injuries.
In order to make electric osmose administration process efficiently to carry out, the signal behavior pulse signal that controllable electric power produces, due to skin
Skin horny layer can occur polarization phenomena in electric osmose administration process, and therefore pulse signal can improve medicine-feeding rate, the frequency of signal
Rate waveform and dutycycle can be finely adjusted according to the concrete condition of medicine.
Meanwhile, in piercing process, needle point keeps vertical with skin surface, so can ensure that micropin is during whole
Fracture will not be occurred to embed skin surface, it is ensured that safety.
Accompanying drawing explanation
Fig. 1 is the structural representation of embodiment 1 percutaneous based on metal porous microneedle array electric osmose doser；
Fig. 2 is the schematic cross-section of the metal porous microneedle array of embodiment 1；
Fig. 3 is the top view of the metal porous microneedle array of embodiment 1；
Fig. 4 is the schematic diagram of embodiment 1 percutaneous electric osmose administration process.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.Wherein, being merely cited for property of accompanying drawing illustrates,
Represent is only schematic diagram, rather than pictorial diagram, it is impossible to it is interpreted as the restriction to this patent；In order to the reality of the present invention is better described
Executing example, some parts of accompanying drawing have omission, zoom in or out, and do not represent the size of actual product；To those skilled in the art
For, in accompanying drawing, some known features and explanation thereof may be omitted and be will be understood by.
The corresponding same or analogous parts of same or analogous label in the accompanying drawing of the embodiment of the present invention；Retouching in the present invention
In stating, it is to be understood that if having term " on ", D score, the orientation of the instruction such as "left", "right" or position relationship be for based on accompanying drawing
Shown orientation or position relationship, be for only for ease of the description present invention and simplify description rather than instruction or imply indication
Device or element must have specific orientation, with specific azimuth configuration and operation, therefore position relationship described in accompanying drawing
Term being merely cited for property explanation, it is impossible to be interpreted as the restriction to this patent, for the ordinary skill in the art, can
To understand the concrete meaning of above-mentioned term as the case may be.
Embodiment 1
As it is shown in figure 1, the percutaneous electric osmose doser based on metal porous microneedle array of the present embodiment includes that metal is many
Hole microneedle array 1, metal porous microneedle array 22, medical physiological electrode 3 and controllable pulse power supply 4.Metal porous micropin battle array
Row 1 and metal porous microneedle array 22 are not attached to mutually, and the material of medical physiological electrode 3 is silver, is shaped as length and width a height of 1:
The cube of 0.5:0.45cm, metal porous microneedle array 1 is connected with the negative electrode of medical physiological electrode 3 by welding manner,
Metal porous microneedle array 22 is connected with the anode of medical physiological electrode 3 by welding manner, the anode of medical physiological electrode 3
Corresponding with controllable pulse power supply 4 respectively with negative electrode connect.
As shown in Figure 2 be the schematic cross-section of metal porous microneedle array.Metal porous micropin selected by this example
The thickness of array substrate 5 is 1.5cm, and the tip height of micropin 6 is 500um, and needle point base diameter is 200um, between pin and pin
Distance be 1mm.Microneedle array porosity is 15%, and mean pore size is 100um.More than set and be to ensure that metal is many
Hole microneedle array both can puncture entrance skin histology, can bring more major injury to people again, and loose structure is again simultaneously
Medicine provides route of administration.Finally this microneedle array is to be formed by titanium alloy micron particle sintering.Titanium alloy has good life
The thing compatibility, will not cause the immunological rejection of skin in piercing process.
As shown in Figure 3 be the top view of metal porous microneedle array, metal porous microneedle array is the pros of 10 × 10
Shape array, the spacing between ranks is 1mm, and whole substrate is the square of 1.5 × 1.5cm, both can ensure that under this spacing
The success rate punctured, the impact can avoided between pin and pin in piercing process again.
It should be noted that metal porous microneedle array one as herein described and metal porous microneedle array two are two one
The metal porous microneedle array of sample, metal porous microneedle array as herein described is metal porous microneedle array one and metal porous
The general designation of microneedle array two.
Shown in Fig. 4 is the schematic diagram of percutaneous electric osmose medication based on metal porous microneedle array, in the present embodiment
Percutaneous electric osmose medication use device as shown in Figure 1, Figure 2 and Figure 3.
The operating procedure that percutaneous electric osmose medication in the present embodiment is concrete is as follows:
A. a certain region of skin tissue surface is chosen as percutaneous dosing district, to its disinfection.
B. liquid medicine is instilled in the needle point of metal porous microneedle array so that prestore in needle point liquid medicine, works as liquid
After body medicine penetrates into metal porous microneedle array, metal porous microneedle array is pressed into skin tissue surface, treats metal porous
Microneedle array punctures after entering and is fixed with medical proof fabric.
C. draw liquid medicine with syringe, and dropwise liquid medicine is instilled the substrate back of the body of metal porous microneedle array
Face, opens controllable pulse power supply, carries out electric osmose administration, and medicine-feeding rate is carried out by the current parameters regulating power supply in administration process
Regulation and control, in the present embodiment, set current signal as pulse signal, and current intensity is 0.5mA, and waveform is square wave, and frequency is
50HZ, conduction time is 10min.
D. it is administered after terminating, takes out metal porous microneedle array, and the region medical alcohol being administered at skin surface enters
Row is disinfected.
Percutaneous electric osmose medication in the present embodiment includes three kinds of administration process, and the first is previously stored in hole
Medicine is diffused into skin histology after micropin punctures through skin, and the second is that medicine passes through micropin battle array along with liquid medicine titrates
The through hole of row enters in skin along needle point from substrate location, and the third is upon power-up, and medicine is by magnetic field and EOF
Effect, rapidly enter in human body.Three kinds of methods combine, and not only efficiency is high, and medicine-feeding rate can regulate and control.
Embodiment two
The present embodiment operational approach is similar with embodiment one, and institute's difference is, the metal selected in the present embodiment
Porous microneedle array porosity is 10%, and microneedle array arrangement is often row 7 totally 7 row.
Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and is not right
The restriction of embodiments of the present invention.For those of ordinary skill in the field, the most also may be used
To make other changes in different forms.Here without also cannot all of embodiment be given exhaustive.All at this
Any amendment, equivalent and the improvement etc. made within the spirit of invention and principle, should be included in the claims in the present invention
Protection domain within.
Claims (9)
1. percutaneous electric osmose doser based on metal porous microneedle array, it is characterised in that include two metal porous micropins
Array, medical physiological electrode and controllable pulse power supply, metal porous microneedle array one leads to the anode of described medical physiological electrode
Crossing welding manner to be connected, metal porous microneedle array two is connected by welding manner with the negative electrode of described medical physiological electrode, institute
State metal porous microneedle array one to be not attached to described metal porous microneedle array two, the anode of described medical physiological electrode and the moon
Pole is corresponding with described controllable pulse power supply respectively to connect.
Device the most according to claim 1, it is characterised in that the described metal porous microneedle array side by metal sintering
Formula is formed, and described metal porous microneedle array shape size is determined by the size of reverse mould microneedle array.
Device the most according to claim 1 and 2, it is characterised in that described metal porous microneedle array material is titanium alloy.
Device the most according to claim 3, it is characterised in that the substrate thickness of described metal porous microneedle array be 3～
15mm, micropin height is 300～600um, and tip height is 30～80um, and the distance between pin and pin is 2～5mm.
Device the most according to claim 4, it is characterised in that the material of described medical physiological electrode is silver or chlorination
Silver, being shaped as of described medical physiological electrode is square or circular.
Device the most according to claim 5, it is characterised in that the current signal of described controllable pulse power supply is pulse letter
Number, current intensity is 0.5mA, and waveform is square wave, and frequency is 50HZ, and conduction time is 10min.
7. a percutaneous electric osmose medication based on metal porous microneedle array, it is characterised in that metal porous microneedle array
One is connected by welding manner with the anode of medical physiological electrode, metal porous microneedle array two and the negative electrode of medical physiological electrode
Being connected by welding manner, described metal porous microneedle array one is not attached to described metal porous microneedle array two, described doctor
Connect with the anode of physiological electrode and negative electrode are corresponding with controllable pulse power supply respectively,
The needle point of described metal porous microneedle array prestores liquid medicine, described using syringe dropwise to be instilled by liquid medicine
During the backside of substrate of metal porous microneedle array, described controllable pulse power initiation, carry out electric osmose administration, be administered
Medicine-feeding rate is regulated and controled by the current parameters regulating described controllable pulse power supply in journey.
Medication the most according to claim 7, it is characterised in that described controllable pulse power supply provides pulse current, adjusts
Medicine-feeding rate is regulated and controled by the joint waveform of pulse current, frequency and dutycycle.
Medication the most according to claim 8, it is characterised in that described metal porous microneedle array such as claim 2
To described in 4, described medical physiological electrode is as claimed in claim 5, and described controllable pulse power supply is as claimed in claim 6.
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