CN110741438B - 具有适应性靶葡萄糖水平的基础滴定 - Google Patents

具有适应性靶葡萄糖水平的基础滴定 Download PDF

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Publication number
CN110741438B
CN110741438B CN201880039764.8A CN201880039764A CN110741438B CN 110741438 B CN110741438 B CN 110741438B CN 201880039764 A CN201880039764 A CN 201880039764A CN 110741438 B CN110741438 B CN 110741438B
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glucose
insulin
time window
measure
measurements
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CN110741438A (zh
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T.B.阿拉多蒂尔
H.本特松
M.L.简森
P.布洛克迈尔
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Novo Nordisk AS
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3561—Range local, e.g. within room or hospital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201880039764.8A 2017-06-15 2018-06-08 具有适应性靶葡萄糖水平的基础滴定 Active CN110741438B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311662916.9A CN117912631A (zh) 2017-06-15 2018-06-08 具有适应性靶葡萄糖水平的基础滴定

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762520139P 2017-06-15 2017-06-15
US62/520139 2017-06-15
US201762522811P 2017-06-21 2017-06-21
US62/522811 2017-06-21
EP17178877.1 2017-06-29
EP17178877 2017-06-29
EP17190146.5 2017-09-08
EP17190146 2017-09-08
PCT/EP2018/065126 WO2018228932A1 (en) 2017-06-15 2018-06-08 Basal titration with adaptive target glucose level

Related Child Applications (1)

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CN110741438A CN110741438A (zh) 2020-01-31
CN110741438B true CN110741438B (zh) 2023-12-29

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US (2) US11298461B2 (enExample)
EP (2) EP3639268B1 (enExample)
JP (2) JP7178370B2 (enExample)
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MA (1) MA49422A (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3826700A1 (en) * 2018-07-26 2021-06-02 Sanofi Method of adjusting medication doses
AU2024234961A1 (en) * 2023-03-16 2025-09-11 University Of Virginia Method for mitigating hypoglycemia rebound in an automated insulin delivery system
WO2024214253A1 (ja) * 2023-04-13 2024-10-17 セルスペクト株式会社 血液検査用補助具
WO2025090855A1 (en) * 2023-10-26 2025-05-01 University Of Virginia Patent Foundation Targeted basal insulin titration using sparse and dense glucose measurements

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005326943A (ja) * 2004-05-12 2005-11-24 Ataru Okumura 投薬支援プログラム、投薬支援装置、投薬支援プログラムを記録した記録媒体及び投薬支援システム
CA2547224A1 (en) * 2005-05-18 2006-11-18 Clarian Health Partners, Inc. System for managing glucose levels in patients with diabetes or hyperglycemia
WO2009048462A1 (en) * 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
WO2010099313A1 (en) * 2009-02-25 2010-09-02 University Of Virginia Patent Foundation Cgm-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction insulin delivery
CN102369032A (zh) * 2009-02-04 2012-03-07 赛诺菲-安万特德国有限公司 用于提供用于血糖控制的信息的医疗系统和方法
TW201333870A (zh) * 2011-12-21 2013-08-16 艾登工具股份有限公司 決定病人胰島素療法的系統及方法
WO2015169814A1 (en) * 2014-05-05 2015-11-12 Joanneum Research Forschungsgesellschaft Mbh Insulin dosage proposal system
JP2016517601A (ja) * 2013-03-15 2016-06-16 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 検体モニタリング装置と関連づけられた装置、システム、および方法、並びにそれらを組み込んだ装置
CN107809943A (zh) * 2015-04-02 2018-03-16 豪夫迈·罗氏有限公司 用于分析从患有糖尿病的人测得的葡萄糖数据的方法和系统

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127370A (en) 1998-12-02 2004-05-12 Yaskawa Eshed Technology Ltd Control system and method for servo mechanism
US6923763B1 (en) 1999-08-23 2005-08-02 University Of Virginia Patent Foundation Method and apparatus for predicting the risk of hypoglycemia
US7404796B2 (en) 2004-03-01 2008-07-29 Becton Dickinson And Company System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor
US20050065760A1 (en) * 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
US20070092888A1 (en) 2003-09-23 2007-04-26 Cornelius Diamond Diagnostic markers of hypertension and methods of use thereof
DK1972270T3 (da) 2007-03-23 2011-01-24 Hoffmann La Roche Fremgangsmåde og glucoseovervågningssystem til overvågning af individuelt metabolisk respons
EP2156684A4 (en) 2007-05-14 2012-10-24 Abbott Diabetes Care Inc METHOD AND DEVICE FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM
WO2009103156A1 (en) 2008-02-20 2009-08-27 Mcmaster University Expert system for determining patient treatment response
US9220456B2 (en) 2008-04-04 2015-12-29 Hygieia, Inc. Systems, methods and devices for achieving glycemic balance
US8600682B2 (en) 2008-04-04 2013-12-03 Hygieia, Inc. Apparatus for optimizing a patient's insulin dosage regimen
TWI394580B (zh) * 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US20100256047A1 (en) * 2009-04-03 2010-10-07 Lifescan, Inc. Analyte Measurement and Management Device and Associated Methods
US8175812B2 (en) 2008-06-25 2012-05-08 Roche Diagnostics Operations, Inc. Method, system, and computer program product for calculating daily weighted averages of glucose measurements (or derived quantities) with time-based weights
CN102481101A (zh) 2009-06-30 2012-05-30 生命扫描有限公司 用于计算基础胰岛素治疗的被分析物测试方法和设备
WO2011084208A1 (en) 2009-12-21 2011-07-14 Stc.Unm System and methods for estimating hba1c, treatment response, and hypoglycemia risk using self-monitoring of blood glucose data
US8532933B2 (en) 2010-06-18 2013-09-10 Roche Diagnostics Operations, Inc. Insulin optimization systems and testing methods with adjusted exit criterion accounting for system noise associated with biomarkers
US10010273B2 (en) * 2011-03-10 2018-07-03 Abbott Diabetes Care, Inc. Multi-function analyte monitor device and methods of use
RU2602040C2 (ru) 2011-08-26 2016-11-10 Университи Оф Вирджиния Патент Фоундэйшион Способ, система и машиночитаемый носитель для адаптационного рекомендательного контроля сахарного диабета
TW201318602A (zh) * 2011-11-14 2013-05-16 Joinsoon Medical Technology Co Ltd 具胰島素參數之血糖檢測統計方法及其血糖檢測機
US9227014B2 (en) 2013-02-07 2016-01-05 The Board Of Trustees Of The Laland Stanford Junior University Kalman filter based on-off switch for insulin pump
WO2014145335A1 (en) 2013-03-15 2014-09-18 Abbott Diabetes Care Inc. System and method to manage diabetes based on glucose median, glucose variability, and hypoglycemic risk
US20150006192A1 (en) 2013-06-26 2015-01-01 WellDoc, Inc. Systems and methods for clinical decision-making
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
WO2015128740A2 (en) 2014-02-28 2015-09-03 Eco-Fusion Systems for predicting hypoglycemia and methods of use thereof
US10722650B2 (en) 2014-03-28 2020-07-28 Roche Diabetes Care, Inc. System and method for adjusting therapy based on risk associated with a glucose state
US10657224B2 (en) 2015-09-25 2020-05-19 Accenture Global Solutions Limited Monitoring and treatment dosage prediction system
US12383166B2 (en) 2016-05-23 2025-08-12 Insulet Corporation Insulin delivery system and methods with risk-based set points
US10304315B2 (en) 2016-06-09 2019-05-28 Amp Llc Systems and methods for health monitoring and providing emergency support
US20190287645A1 (en) 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
US10971030B2 (en) 2017-01-26 2021-04-06 International Business Machines Corporation Remote physical training

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005326943A (ja) * 2004-05-12 2005-11-24 Ataru Okumura 投薬支援プログラム、投薬支援装置、投薬支援プログラムを記録した記録媒体及び投薬支援システム
CA2547224A1 (en) * 2005-05-18 2006-11-18 Clarian Health Partners, Inc. System for managing glucose levels in patients with diabetes or hyperglycemia
WO2009048462A1 (en) * 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
CN102369032A (zh) * 2009-02-04 2012-03-07 赛诺菲-安万特德国有限公司 用于提供用于血糖控制的信息的医疗系统和方法
WO2010099313A1 (en) * 2009-02-25 2010-09-02 University Of Virginia Patent Foundation Cgm-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction insulin delivery
TW201333870A (zh) * 2011-12-21 2013-08-16 艾登工具股份有限公司 決定病人胰島素療法的系統及方法
JP2016517601A (ja) * 2013-03-15 2016-06-16 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 検体モニタリング装置と関連づけられた装置、システム、および方法、並びにそれらを組み込んだ装置
WO2015169814A1 (en) * 2014-05-05 2015-11-12 Joanneum Research Forschungsgesellschaft Mbh Insulin dosage proposal system
CN107809943A (zh) * 2015-04-02 2018-03-16 豪夫迈·罗氏有限公司 用于分析从患有糖尿病的人测得的葡萄糖数据的方法和系统

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Glucose Measurement: Confounding Issue in Setting Targets for Inpatient Management;Kathleen Dungan et.al;Diabetes Care;第30卷(第2期);第403-409页 *
The introduction of insulin in type 2 diabetes mellitus;Jencia Wong et.al;Australian Family Physician;第44卷(第5期);第278-283页 *

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JP2022095682A (ja) 2022-06-28
US20220184310A1 (en) 2022-06-16
US12109392B2 (en) 2024-10-08
CN117912631A (zh) 2024-04-19
JP2020524844A (ja) 2020-08-20
EP3639268A1 (en) 2020-04-22
JP7178370B2 (ja) 2022-11-25
JP7389834B2 (ja) 2023-11-30
EP3758008A1 (en) 2020-12-30
US11298461B2 (en) 2022-04-12
MA49422A (fr) 2020-04-22
CN110741438A (zh) 2020-01-31
US20210146046A1 (en) 2021-05-20
EP3639268B1 (en) 2024-10-09

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