CN110720453A - Bactericidal emulsifier based on tricyclazole and preparation method and application thereof - Google Patents

Bactericidal emulsifier based on tricyclazole and preparation method and application thereof Download PDF

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Publication number
CN110720453A
CN110720453A CN201911097919.6A CN201911097919A CN110720453A CN 110720453 A CN110720453 A CN 110720453A CN 201911097919 A CN201911097919 A CN 201911097919A CN 110720453 A CN110720453 A CN 110720453A
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CN
China
Prior art keywords
tricyclazole
emulsifier
bactericidal
stirring
solution
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Pending
Application number
CN201911097919.6A
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Chinese (zh)
Inventor
杨月忠
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JIANGSU JIANSHEN BIOLOGY AGROCHEMICAL Co Ltd
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JIANGSU JIANSHEN BIOLOGY AGROCHEMICAL Co Ltd
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Priority to CN201911097919.6A priority Critical patent/CN110720453A/en
Publication of CN110720453A publication Critical patent/CN110720453A/en
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06Aerosols
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10Macromolecular compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Abstract

The invention discloses a bactericidal emulsifier based on tricyclazole and a preparation method and application thereof, wherein the bactericidal emulsifier comprises the following components in percentage by weight: 20-40% of tricyclazole; 4% -8% of cosolvent; 1% -6% of an emulsifier; 0.1-2% of lactic acid-glycolic acid copolymer solution with the concentration of 10%; 1-2% of thickening stabilizer; 30-50% of solvent. The invention prepares the low-concentration bactericidal emulsifier based on the tricyclazole by mixing the tricyclazole, the dissolution-assisting polyvinyl alcohol, the cetearyl alcohol, the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, the dichloromethane solution with good slow release property and the content of the biodegradable lactic acid-glycolic acid copolymer of 10 percent and the dimethylacetamide solvent, and can effectively solve the technical defects that the existing tricyclazole medicament is easy to be quickly absorbed by the root system of a rice plant after being applied, has short antibacterial sterilization time and poor later-period control effect, and the high-concentration tricyclazole medicament has high toxicity and easily causes high toxicity and high residual medicament in plants.

Description

Bactericidal emulsifier based on tricyclazole and preparation method and application thereof
Technical Field
The invention relates to a bactericidal emulsifier based on tricyclazole, a preparation method and application thereof, and belongs to the technical field of biological product research and development.
Background
The existing tricyclazole medicament is easy to be quickly absorbed by the root system of a rice plant after being applied, the phenomena of short antibacterial sterilization time and poor later-stage control effect are prominent, and the high-concentration tricyclazole medicament has high toxicity and is easy to cause high toxicity and high residual medicament in plants. There is therefore a need to develop a sustained long-acting antimicrobial sterilization, slow-release low-concentration bactericidal emulsifier based on tricyclazole.
Disclosure of Invention
The invention aims to overcome the technical defects in the prior art, solve the technical problems and provide a tricyclazole-based bactericidal emulsifier, a preparation method and application.
The invention adopts the following technical scheme: the tricyclazole-based bactericidal emulsifier is characterized by comprising the following components in percentage by weight:
20-40% of tricyclazole; 4% -8% of cosolvent; 1% -6% of an emulsifier; 0.1-2% of lactic acid-glycolic acid copolymer solution with the concentration of 10%; 1-2% of thickening stabilizer; 30-50% of solvent.
As a preferred embodiment, the bactericidal emulsifier is prepared from the following components in percentage by weight:
20-30% of tricyclazole; 4% -6% of cosolvent; 2% -5% of an emulsifier; 0.2-1% of lactic acid-glycolic acid copolymer solution with the concentration of 10%; 1-2% of thickening stabilizer; 30-40% of solvent.
As a preferred example, the thickening stabilizer is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
As a preferred embodiment, the cosolvent is polyvinyl alcohol.
As a preferred example, the solvent is dimethylacetamide.
As a preferred example, the emulsifier is cetearyl alcohol.
In a preferred embodiment, the lactic acid-glycolic acid copolymer solution is a dichloromethane solution with a lactic acid-glycolic acid copolymer content of 10%.
The invention also provides a preparation method of the bactericidal emulsifier based on tricyclazole, which is characterized by comprising the following steps:
step SS 1: dissolving tricyclazole in partial solvent under stirring for 10 min;
step SS 2: adding a cosolvent into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding an emulsifier into the solution prepared in the step SS2, stirring for 10min, then adding a thickening stabilizer, and stirring for 10 min;
step SS 4: dissolving a lactic acid-glycolic acid copolymer solution with the concentration of 10% by using the balance solvent, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
As a preferred embodiment, the preparation method comprises the following steps:
step SS 1: dissolving tricyclazole in part of dimethylacetamide under stirring for 10 min;
step SS 2: adding polyvinyl alcohol into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding cetearyl alcohol into the solution prepared in the step SS2, stirring for 10min, then adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring for 10 min;
step SS 4: dissolving lactic acid-glycolic acid copolymer solution with the concentration of 10% with the balance of dimethyl acetamide, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
The invention also provides the application of the bactericidal emulsifier based on the tricyclazole as a slow-release bactericide and the propagation of the underground strain to be prepared.
The invention achieves the following beneficial effects: aiming at the problems that the existing tricyclazole medicament is easily and rapidly absorbed by the root system of a rice plant after being applied, has short antibacterial sterilization time and poor later-stage control effect, has high toxicity and high residual medicament content in plants, and urgently needs to develop a technical requirement for continuously and long-acting antibacterial sterilization and slowly releasing low-concentration tricyclazole-based bactericidal emulsifier, the invention prepares the low-concentration tricyclazole-based bactericidal emulsifier by mixing the low-concentration tricyclazole, cosolvent polyvinyl alcohol, emulsifying cetearyl alcohol, stable and thickened hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, a dichloromethane solution with the content of biodegradable lactic acid-glycolic acid copolymer being 10 percent and a dimethylacetamide solvent, and the bactericidal emulsifier is prepared by adding more water (on the basis of not damaging the plants) into slow-release spray application in the application process, the tricyclazole is slowly released along with the dissolution of cetostearyl alcohol for emulsification, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer for stable thickening, dichloromethane solution with the content of lactic acid-glycolic acid copolymer for slow release being 10 percent and dimethylacetamide solvent, so that the antibacterial sterilization is long in duration and slowly released, and the technical defects that the existing tricyclazole medicament is easily and quickly absorbed by rice plant roots after being applied, the antibacterial sterilization is short in time, the later-period control effect is poor, the high-concentration tricyclazole medicament is high in toxicity, and the plants are easily high in toxicity and high in residual medicament are effectively overcome.
Detailed Description
The invention is further described below. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
Example 1, preparation of 20% tricyclazole-based germicidal emulsifier.
The bactericidal emulsifier is prepared from the following components in percentage by weight:
20% of tricyclazole; 4% of polyvinyl alcohol; cetostearyl alcohol 1%; 0.5 percent of dichloromethane solution with the content of lactic acid-glycolic acid copolymer of 10 percent; 1% of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer; the rest is dimethylacetamide.
The preparation method comprises the following steps:
step SS 1: dissolving tricyclazole in part of dimethylacetamide under stirring for 10 min;
step SS 2: adding polyvinyl alcohol into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding cetearyl alcohol into the solution prepared in the step SS2, stirring for 10min, then adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring for 10 min;
step SS 4: dissolving lactic acid-glycolic acid copolymer solution with the concentration of 10% with the balance of dimethyl acetamide, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
Example 2, preparation of 30% tricyclazole-based bactericidal emulsifier.
The bactericidal emulsifier is prepared from the following components in percentage by weight:
30% of tricyclazole; 5% of polyvinyl alcohol; cetostearyl alcohol 2%; 1% of dichloromethane solution with the content of lactic acid-glycolic acid copolymer of 10%; 1.5 percent of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer; the rest is dimethylacetamide.
The preparation method comprises the following steps:
step SS 1: dissolving tricyclazole in part of dimethylacetamide under stirring for 10 min;
step SS 2: adding polyvinyl alcohol into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding cetearyl alcohol into the solution prepared in the step SS2, stirring for 10min, then adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring for 10 min;
step SS 4: dissolving lactic acid-glycolic acid copolymer solution with the concentration of 10% with the balance of dimethyl acetamide, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
Example 3, preparation of 40% tricyclazole-based bactericidal emulsifier.
The bactericidal emulsifier is prepared from the following components in percentage by weight:
40% of tricyclazole; 8% of polyvinyl alcohol; cetostearyl alcohol 2%; 2% of dichloromethane solution with the content of lactic acid-glycolic acid copolymer of 10%; 2% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer; the rest is dimethylacetamide.
The preparation method comprises the following steps:
step SS 1: dissolving tricyclazole in part of dimethylacetamide under stirring for 10 min;
step SS 2: adding polyvinyl alcohol into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding cetearyl alcohol into the solution prepared in the step SS2, stirring for 10min, then adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring for 10 min;
step SS 4: dissolving lactic acid-glycolic acid copolymer solution with the concentration of 10% with the balance of dimethyl acetamide, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims (10)

1. The tricyclazole-based bactericidal emulsifier is characterized by comprising the following components in percentage by weight:
20-40% of tricyclazole; 4% -8% of cosolvent; 1% -6% of an emulsifier; 0.1-2% of lactic acid-glycolic acid copolymer solution with the concentration of 10%; 1-2% of thickening stabilizer; 30-50% of solvent.
2. The tricyclazole-based bactericidal emulsifier according to claim 1, wherein the bactericidal emulsifier comprises the following components by weight percent:
20-30% of tricyclazole; 4% -6% of cosolvent; 2% -5% of an emulsifier; 0.2-1% of lactic acid-glycolic acid copolymer solution with the concentration of 10%; 1-2% of thickening stabilizer; 30-40% of solvent.
3. The tricyclazole-based bactericidal emulsifier according to claim 1, wherein the thickening stabilizer is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
4. The tricyclazole-based bactericidal emulsifier according to claim 1, wherein the cosolvent is polyvinyl alcohol.
5. The tricyclazole-based bactericidal emulsifier according to claim 1, wherein the solvent is dimethylacetamide.
6. The tricyclazole-based bactericidal emulsifier according to claim 1, wherein the emulsifier is cetearyl alcohol.
7. The tricyclazole-based bactericidal emulsifier according to claim 1, wherein the lactic acid-glycolic acid copolymer solution is a dichloromethane solution with a lactic acid-glycolic acid copolymer content of 10%.
8. A method for preparing the tricyclazole-based bactericidal emulsifier of claim 1, comprising the steps of:
step SS 1: dissolving tricyclazole in partial solvent under stirring for 10 min;
step SS 2: adding a cosolvent into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding an emulsifier into the solution prepared in the step SS2, stirring for 10min, then adding a thickening stabilizer, and stirring for 10 min;
step SS 4: dissolving a lactic acid-glycolic acid copolymer solution with the concentration of 10% by using the balance solvent, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
9. The preparation method of the tricyclazole-based bactericidal emulsifier according to claim 8, wherein the preparation method comprises the following steps:
step SS 1: dissolving tricyclazole in part of dimethylacetamide under stirring for 10 min;
step SS 2: adding polyvinyl alcohol into the solution prepared in the step SS1, and stirring for 10 min;
step SS 3: adding cetearyl alcohol into the solution prepared in the step SS2, stirring for 10min, then adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring for 10 min;
step SS 4: dissolving lactic acid-glycolic acid copolymer solution with the concentration of 10% with the balance of dimethyl acetamide, adding the obtained solution into the solution prepared in the step SS3, and stirring for 20min for mixing to obtain the bactericidal emulsifier.
10. Use of the tricyclazole-based bactericidal emulsifier according to claim 1 as a slow-release bactericide and for propagation of pseudosubterranean strains.
CN201911097919.6A 2019-11-12 2019-11-12 Bactericidal emulsifier based on tricyclazole and preparation method and application thereof Pending CN110720453A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101069501A (en) * 2007-05-28 2007-11-14 江苏龙灯化学有限公司 Use of double substituted long-chain alkylamido sulfonates as crystallization inhibitor in azoles farm chemicals
CN103548823A (en) * 2013-11-09 2014-02-05 福建农林大学 Method for preparing thiophanate-methyl nano-pesticide
CN104336011A (en) * 2014-10-20 2015-02-11 贵州大学 Pesticide emulsifiable concentrate containing methanesulfonyl myclobutanil
CN107372578A (en) * 2017-07-26 2017-11-24 南通功成精细化工有限公司 A kind of hygienic biocide suspension emulsion and preparation method thereof
CN109258658A (en) * 2018-10-25 2019-01-25 江苏生久农化有限公司 The preparation method and application of pesticidal preparations containing pyraclostrobin and Tebuconazole

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101069501A (en) * 2007-05-28 2007-11-14 江苏龙灯化学有限公司 Use of double substituted long-chain alkylamido sulfonates as crystallization inhibitor in azoles farm chemicals
CN103548823A (en) * 2013-11-09 2014-02-05 福建农林大学 Method for preparing thiophanate-methyl nano-pesticide
CN104336011A (en) * 2014-10-20 2015-02-11 贵州大学 Pesticide emulsifiable concentrate containing methanesulfonyl myclobutanil
CN107372578A (en) * 2017-07-26 2017-11-24 南通功成精细化工有限公司 A kind of hygienic biocide suspension emulsion and preparation method thereof
CN109258658A (en) * 2018-10-25 2019-01-25 江苏生久农化有限公司 The preparation method and application of pesticidal preparations containing pyraclostrobin and Tebuconazole

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Application publication date: 20200124