CN110715965A - Preparation method of double-sided physiological value test piece and product - Google Patents
Preparation method of double-sided physiological value test piece and product Download PDFInfo
- Publication number
- CN110715965A CN110715965A CN201910865040.5A CN201910865040A CN110715965A CN 110715965 A CN110715965 A CN 110715965A CN 201910865040 A CN201910865040 A CN 201910865040A CN 110715965 A CN110715965 A CN 110715965A
- Authority
- CN
- China
- Prior art keywords
- layer
- film
- photoresist
- double
- photoresist layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/27—Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
- G03F7/0035—Multiple processes, e.g. applying a further resist layer on an already in a previously step, processed pattern or textured surface
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention discloses a preparation method of a double-sided physiological value test piece, which comprises the following steps: adhering the first surface of the film to the base material through an adhesive; coating a photoresist material on the second surface of the film to form a first photoresist layer, shielding the first photoresist layer by using a mask, and irradiating to form a pattern layer; plating a metal layer on the pattern layer; removing the first photoresist layer which is not removed by irradiation, and forming a test circuit on the metal layer on the first surface; coating a layer of insulating material on the test circuit to form an insulating layer, and coating a photoresist material on the insulating layer to form a second photoresist layer; removing the second photoresist layer above the test circuit through the mask, and removing the insulating layer above the test circuit and the second photoresist layer which is not removed by irradiation to form an insulating layer between the test circuits; and adhering the second surface to the substrate, and repeating the steps to obtain the test piece. The method can effectively simplify the preparation process.
Description
Technical Field
The invention belongs to the technical field of test pieces, and particularly relates to a preparation method of a double-sided physiological value test piece and a product.
Background
With the advancement of medical technology, the average human life is continuously prolonged, but the life is also accompanied by the appearance of various diseases. Among them, diabetes is a metabolic disease characterized in that the blood glucose level of a patient is at a high level for a long period of time. This hyperglycemic state causes three or fewer symptoms: polyphagia, polydipsia, polyuria and weight loss. If the symptoms persist and are not treated, many complications may ensue, such as: blurred vision, headaches, muscle weakness, and the like.
To avoid this, monitoring blood glucose concentration at any time is an important step in controlling the diabetes process. Currently, a conventional blood glucose test strip is usually used to detect the blood glucose concentration in blood, and the detection method needs to be matched with a blood glucose meter to measure the blood glucose content in blood by the electrochemical analysis principle. Therefore, there is a considerable need in the market for a blood glucose test strip as a blood glucose test method that is currently used.
The existing blood sugar test strip technology forms a plurality of test circuits on a substrate at the same time, and then cuts the substrate to form a plurality of test strips. For example, chinese patent publication No. CN1982886 discloses a batch manufacturing method of electrochemical biosensing test piece and a manufacturing method of metal electrode thereof, wherein a metal film is obtained first, and then a plurality of electrode separation lines are cut on the metal film by cutting with a cutting die, so that the same metal film is cut into a plurality of metal electrodes required for detecting the electrochemical biosensing test piece; because the metal film can be manufactured in a large area in a coiling manner in advance, when the metal film is matched with a cutting die to cut, batch metal electrodes can be quickly cut from the metal film, the cut edge is smooth, and the problem of chemical residue is completely solved, the cost of the cutting method by adopting the cutting die is lower than that of laser cutting, and the high-quality metal electrodes required by the electrochemical biological sensing test piece can be quickly produced in batch.
However, the method for preparing such a blood glucose test strip is complicated and costly.
Therefore, a method for manufacturing a double-sided physiological value test strip capable of improving the above-mentioned defects is one of the development targets in the related industries.
Disclosure of Invention
The invention aims to provide a preparation method of a double-sided physiological value test piece and a product.
A preparation method of a double-sided physiological value test piece comprises the following steps:
(1) the first surface of the film is adhered to the base material through an adhesive, wherein any one of two opposite surfaces of the film is the first surface;
(2) coating a photoresist material on the second surface of the film to form a first photoresist layer, shielding the first photoresist layer by a pattern cover with a set pattern, and irradiating to form a pattern layer, wherein the pattern layer comprises the first photoresist layer shielded by the pattern cover and a film layer exposed after the first photoresist layer is removed by irradiation;
(3) plating a metal layer on the pattern layer formed in the step (2);
(4) removing the first photoresist layer which is not removed by irradiation in the step (2), and forming a test circuit on the metal layer on the first surface;
(5) coating a layer of insulating material on the test circuit formed in the step (4) to form an insulating layer, wherein the height of the insulating layer is greater than the thickness of the test circuit, and then coating a photoresist material on the insulating layer to form a second photoresist layer; shielding the second photoresist layer through the pattern cover, removing the second photoresist layer above the test circuit after irradiation, removing the insulating layer above the test circuit and the second photoresist layer which is not removed by irradiation, and forming an insulating layer between the test circuits;
(6) and (3) after the film is taken off from the substrate, adhering the second surface to the substrate, and repeating the steps (1) to (5) to obtain the test piece with the test circuit and the insulating layer on both sides.
In steps (2) and (5), the first or second photoresist layer not removed by irradiation is the region of the photoresist layer shielded by the mask, the thin film layer exposed after the first photoresist layer removed by irradiation is the region of the photoresist layer not shielded by the mask, and the thin film layer is exposed after the photoresist layer is removed.
In steps (2) and (5), irradiation is performed using ultraviolet light.
The film is selected from a polyamide film, a polyester film, a polyimide film, a polyethylene terephthalate film or a polyvinyl chloride film.
The heat-resistant temperature of the adhesive is higher than 100 ℃, and the adhesive force between the adhesive and the base material is higher than that between the adhesive and the film.
The materials of the first light resistance layer and the second light resistance layer are light resistance liquid or ink.
The material of the metal layer is selected from gold, palladium, silver or platinum.
The invention also provides a double-sided physiological value test piece prepared by the preparation method.
Compared with the prior art, the preparation method of the double-sided physiological value test piece provided by the invention has the advantages that after the test circuit is formed on the first surface of the film, the film is taken down from the substrate, and then a second test circuit can be formed on the second surface of the film. The preparation method provided by the invention can effectively simplify the existing preparation process, and the prepared test piece can be used as a double-sided test piece.
Drawings
FIG. 1 is a flow chart of a method for preparing a double-sided physiological value test strip according to the present invention;
FIG. 2 is a perspective view of a double-sided physiological value test strip prepared according to the present invention;
fig. 3a to 3k in fig. 3 are schematic process diagrams of a method for preparing a double-sided physiological value test strip in an embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the detailed description and specific examples, while indicating the scope of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention. In addition, the drawings are only for illustrative purposes and are not drawn to scale.
As shown in fig. 1 and 3a to 3k in fig. 3, the method for preparing a double-sided physiological value test strip provided by the present invention comprises the following steps:
pasting step S1: as shown in fig. 3a, the film 1 is adhered to the substrate 2 by an adhesive, wherein the film 1 includes a first surface 11 and a second surface 12, the first surface 11 and the second surface 12 are respectively located at opposite sides, and the second surface 12 faces the substrate 2 to be adhered.
Pattern forming step S2: as shown in fig. 3b and 3c, a first photoresist layer 111 is formed after coating a photoresist material on the first surface 11 of the film 1, the first photoresist layer 111 is masked by a mask 112 with a predetermined pattern, and a pattern layer is formed after ultraviolet irradiation, the pattern layer includes the first photoresist layer 111 which is not removed by irradiation and the first surface 11 which is exposed after removing the first photoresist layer 111 by irradiation.
Metal layer forming step S3: as shown in fig. 3d, the pattern layer formed in step S2 is plated with a metal layer 113.
Test line forming step S4: as shown in fig. 3e and 3f, the first photoresist layer 111 and the metal layer 113 on the first photoresist layer 111 that are not removed by irradiation in step S3 are removed, and the metal layer 113 on the first surface 11 forms a test line 114.
Insulating layer forming step S5: as shown in fig. 3g-3k, an insulating layer 115 is formed by coating a layer of insulating material on the test circuit 114, the height of the insulating layer 115 is greater than the thickness of the test circuit 114, and a second photoresist layer 116 is formed by coating a photoresist material on the insulating layer 115; the second photoresist layer 116 is masked by the mask 117, the second photoresist layer 116 on the test line 114 is removed after irradiation, and the insulating layer 115 on the test line 114 and the second photoresist layer 116 not removed after irradiation are removed by plasma, thereby forming an insulating layer 115 between the test lines 114.
After the film 1 is removed from the substrate 2, the first surface 11 is attached to the substrate 2, and steps S1 to S5 are repeated to obtain a test piece having test traces and an insulating layer on both surfaces. The test piece was prepared by a schematic structure as shown in FIG. 2, having test wiring 114 and an insulating layer on both opposite surfaces 11 and 12 of the film 1.
The Film is a Polyimide Film (PI), and the PI Film has excellent radiation resistance, high dielectric constant, electrical insulation, high temperature resistance, low temperature resistance, and the like, but is not limited thereto, and other materials having the above excellent properties may be used. The substrate may be glass, but is not limited thereto.
Preferably, the heat-resistant temperature of the adhesive is greater than 100 ℃, and because an environment higher than 100 ℃ may occur in the preparation process, the heat-resistant temperature of the adhesive needs to be greater than 100 ℃, so that the film and the glass can be stably combined and are not easy to be displaced by other factors. And the adhesive force of the adhesive on the base material 2 is larger than that of the adhesive on the film 1, so that the film 1 can be easily taken off from the base material when the film 1 is taken off, and the adhesive is left on the base material because the adhesive force of the adhesive on the base material 2 is larger and cannot be remained on the film 1.
The material of the first photoresist layer and the second photoresist layer is photoresist or ink, but not limited thereto. The material of the metal layer may be selected from gold, palladium, silver, platinum or other noble metals.
The preparation method provided by the invention adopts a lift-off process, but is not limited to the lift-off process.
In this embodiment, the film 1 is adhered to the substrate 2 by the second surface 12. In fig. 3a, first, a first photoresist layer 111 is formed on the first surface 11, and may be formed by using photoresist or ink. In fig. 3b, a mask 112 is used to cover the first photoresist layer 111 and ultraviolet exposure is performed. In FIG. 3c, the mask 112 is removed such that the first photoresist layer 111 is formed on the first surface 11 of the film 1 at intervals. In FIG. 3d, a metal layer 113 is formed on the first photoresist layer 111 on the first surface 11 of the film 1, for example, the metal layer 113 may be formed by sputtering. In FIG. 3e, the metal layer 113 and the first photoresist layer 111 on the first surface 11 of the film 1 are precisely removed by a plasma gun, and finally the test line 114 is formed.
Therefore, the method for manufacturing the double-sided physiological value test piece can effectively simplify the existing process and can achieve the effect of manufacturing the double-sided physiological value test piece.
The above-mentioned embodiments are intended to illustrate the technical solutions and advantages of the present invention, and it should be understood that the above-mentioned embodiments are only the most preferred embodiments of the present invention, and are not intended to limit the present invention, and any modifications, additions, equivalents, etc. made within the scope of the principles of the present invention should be included in the scope of the present invention.
Claims (6)
1. The preparation method of the double-sided physiological value test piece is characterized by comprising the following steps of:
(1) the first surface of the film is adhered to the base material through an adhesive, wherein any one of two opposite surfaces of the film is the first surface;
(2) coating a photoresist material on the second surface of the film to form a first photoresist layer, shielding the first photoresist layer by a pattern cover with a set pattern, and irradiating to form a pattern layer, wherein the pattern layer comprises the first photoresist layer which is not removed by irradiation and a film layer which is exposed after the first photoresist layer is removed by irradiation;
(3) plating a metal layer on the pattern layer formed in the step (2);
(4) removing the first photoresist layer which is not removed by irradiation in the step (2), and forming a test circuit on the metal layer on the first surface;
(5) coating a layer of insulating material on the test circuit formed in the step (4) to form an insulating layer, wherein the height of the insulating layer is greater than the thickness of the test circuit, and then coating a photoresist material on the insulating layer to form a second photoresist layer; shielding the second photoresist layer through the pattern cover, removing the second photoresist layer above the test circuit after irradiation, removing the insulating layer above the test circuit and the second photoresist layer which is not removed by irradiation, and forming an insulating layer between the test circuits;
(6) and (3) after the film is taken off from the substrate, adhering the second surface to the substrate, and repeating the steps (1) to (5) to obtain the test piece with the test circuit and the insulating layer on both sides.
2. The method for preparing a double-sided physiological value test piece according to claim 1, wherein the film is selected from a polyamide film, a polyester film, a polyimide film, a polyethylene terephthalate film or a polyvinyl chloride film.
3. The method for preparing a double-sided physiological value test piece according to claim 1, wherein the heat-resistant temperature of the adhesive is higher than 100 ℃, and the adhesion between the adhesive and the substrate is higher than the adhesion between the adhesive and the film.
4. The method for preparing a double-sided physiological value test piece according to claim 1, wherein the material of the first light-blocking layer and the second light-blocking layer is a photoresist liquid or ink.
5. The method for preparing a double-sided physiological value test piece according to claim 1, wherein the material of the metal layer is selected from gold, palladium, silver or platinum.
6. A double-sided physiological numerical value test sheet prepared by the method for preparing a double-sided physiological numerical value test sheet according to any one of claims 1 to 5.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910865040.5A CN110715965B (en) | 2019-09-09 | 2019-09-09 | Double-sided physiological value test piece and preparation method thereof |
| PCT/CN2020/113728 WO2021047469A1 (en) | 2019-09-09 | 2020-09-07 | Production method for double-sided physiological value test strip, and product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910865040.5A CN110715965B (en) | 2019-09-09 | 2019-09-09 | Double-sided physiological value test piece and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110715965A true CN110715965A (en) | 2020-01-21 |
| CN110715965B CN110715965B (en) | 2020-08-18 |
Family
ID=69210411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910865040.5A Active CN110715965B (en) | 2019-09-09 | 2019-09-09 | Double-sided physiological value test piece and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN110715965B (en) |
| WO (1) | WO2021047469A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021047469A1 (en) * | 2019-09-09 | 2021-03-18 | 浙江大学 | Production method for double-sided physiological value test strip, and product |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201607421U (en) * | 2010-03-02 | 2010-10-13 | 翰沃生电科技股份有限公司 | Planar biological detection test piece |
| CN102072928A (en) * | 2009-11-20 | 2011-05-25 | 厚美德生物科技股份有限公司 | Test strip with double-sided structure and test device |
| JP2014040040A (en) * | 2012-08-22 | 2014-03-06 | Lintec Corp | Double-sided release sheet and use method of the same |
| CN104797086A (en) * | 2014-01-17 | 2015-07-22 | 冠捷投资有限公司 | Method for forming circuit pattern on substrate |
| US20170052169A1 (en) * | 2013-11-18 | 2017-02-23 | Johnson Electric S.A. | Method and system for assembling a microfluidic sensor |
| CN106645349A (en) * | 2016-12-28 | 2017-05-10 | 业成科技（成都）有限公司 | Blood glucose test strip and production method thereof |
| CN108414594A (en) * | 2017-02-10 | 2018-08-17 | 琦芯科技股份有限公司 | Biological sensing test piece made of non-etching solvent and its making method |
| CN108711548A (en) * | 2018-05-21 | 2018-10-26 | 深圳市华星光电技术有限公司 | Metal oxide thin-film transistor and preparation method thereof, display |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009272571A (en) * | 2008-05-09 | 2009-11-19 | Mitsui Mining & Smelting Co Ltd | Printed circuit board and method of manufacturing the same |
| CN101750443A (en) * | 2009-12-31 | 2010-06-23 | 立威生技实业股份有限公司 | Biological detecting test piece electrode, making method thereof, and biological detecting test piece |
| CN103384450B (en) * | 2012-05-04 | 2016-12-28 | 远东新世纪股份有限公司 | A kind of preparation method of the circuit board with patterned conductive layer |
| TW201415015A (en) * | 2012-10-15 | 2014-04-16 | Ichia Tech Inc | Method for manufacturing test plate for biologic liquid and structure for the same |
| CN107105577B (en) * | 2017-04-17 | 2020-09-29 | 复旦大学 | Template transfer process for preparing double-sided and multilayer printed circuit |
| CN110715965B (en) * | 2019-09-09 | 2020-08-18 | 浙江大学 | Double-sided physiological value test piece and preparation method thereof |
-
2019
- 2019-09-09 CN CN201910865040.5A patent/CN110715965B/en active Active
-
2020
- 2020-09-07 WO PCT/CN2020/113728 patent/WO2021047469A1/en active Application Filing
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102072928A (en) * | 2009-11-20 | 2011-05-25 | 厚美德生物科技股份有限公司 | Test strip with double-sided structure and test device |
| CN201607421U (en) * | 2010-03-02 | 2010-10-13 | 翰沃生电科技股份有限公司 | Planar biological detection test piece |
| JP2014040040A (en) * | 2012-08-22 | 2014-03-06 | Lintec Corp | Double-sided release sheet and use method of the same |
| US20170052169A1 (en) * | 2013-11-18 | 2017-02-23 | Johnson Electric S.A. | Method and system for assembling a microfluidic sensor |
| CN104797086A (en) * | 2014-01-17 | 2015-07-22 | 冠捷投资有限公司 | Method for forming circuit pattern on substrate |
| CN106645349A (en) * | 2016-12-28 | 2017-05-10 | 业成科技（成都）有限公司 | Blood glucose test strip and production method thereof |
| CN108414594A (en) * | 2017-02-10 | 2018-08-17 | 琦芯科技股份有限公司 | Biological sensing test piece made of non-etching solvent and its making method |
| CN108711548A (en) * | 2018-05-21 | 2018-10-26 | 深圳市华星光电技术有限公司 | Metal oxide thin-film transistor and preparation method thereof, display |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021047469A1 (en) * | 2019-09-09 | 2021-03-18 | 浙江大学 | Production method for double-sided physiological value test strip, and product |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110715965B (en) | 2020-08-18 |
| WO2021047469A1 (en) | 2021-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7419573B2 (en) | Circuit for electrochemical sensor strip | |
| US7387714B2 (en) | Electrochemical sensor strip | |
| US7294246B2 (en) | Electrode for electrochemical sensors | |
| JP3193721B2 (en) | Manufacturing method of sensor electrode | |
| CA2625833A1 (en) | Analyte sensor and method of making it | |
| CN110715965B (en) | Double-sided physiological value test piece and preparation method thereof | |
| CN101750443A (en) | Biological detecting test piece electrode, making method thereof, and biological detecting test piece | |
| EP2572194A1 (en) | Analytical test strip with an electrode having electrochemically active and inert ares of a predetermined size and distribution | |
| US10655210B2 (en) | Roll-to-roll sputtering process with hybrid target and product thereof | |
| CA2952323C (en) | End-fill electrochemical-based analytical test strip with perpendicular intersecting sample-receiving chambers | |
| TWI662276B (en) | Electrode film for blood glucose sensor | |
| WO2016008333A1 (en) | Method for arranging conductive component of electrochemical sensing test piece | |
| US20160202204A1 (en) | Electrochemical-based analytical test strip with ultra-thin discontinuous metal layer | |
| KR101753133B1 (en) | Method of manufacturing planar bio-test strip and product thereof | |
| WO2023222052A1 (en) | Biosensor and manufacturing method therefor | |
| US20090277565A1 (en) | Process for Making Electrodes for Test Sensors | |
| TW201608237A (en) | Electrode for biosensor and method for manufacturing the same | |
| TWI624664B (en) | Electrochemical sensing test piece conductive member setting method and electrochemical sensing thereof Audition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |