CN110713752A - Pen ink for surgical marking pen and preparation method thereof - Google Patents
Pen ink for surgical marking pen and preparation method thereof Download PDFInfo
- Publication number
- CN110713752A CN110713752A CN201911064022.3A CN201911064022A CN110713752A CN 110713752 A CN110713752 A CN 110713752A CN 201911064022 A CN201911064022 A CN 201911064022A CN 110713752 A CN110713752 A CN 110713752A
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- China
- Prior art keywords
- pen
- parts
- pen ink
- red pigment
- beet red
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/16—Writing inks
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/16—Writing inks
- C09D11/17—Writing inks characterised by colouring agents
Abstract
The invention provides pen ink for a surgical marking pen and a preparation method thereof, and relates to the technical field of medical instruments, wherein the pen ink comprises the following raw materials in parts by weight: 10-25 parts of beet red pigment, 30-50 parts of water, 8-15 parts of chitosan and 2-5 parts of polyvinylpyrrolidone/eicosene copolymer. The pen ink can be filled in a marking pen and applied to the marking pen for operation. The pen ink disclosed by the invention takes natural pigment as a raw material, so that the pen ink is safer for patients.
Description
Technical Field
The invention relates to the technical field of medical supplies, in particular to pen ink for a surgical marking pen and a preparation method thereof.
Background
According to research, about 1300-2700 medical accidents with wrong operation positions occur in the United states every year, and serious damage is caused to the physical and mental health of patients. In order to prevent the position and the operation form of the operation patient from being wrong and ensure the life safety of the patient so as to ensure the normative and the effectiveness of the patient. The marking pen is used for carrying out body surface identification on the operation position of a patient before an operation by an operation doctor clinically, so that the detail management of an operating room is enhanced, and the error of the operation position is prevented.
Currently, a marker on the skin of a patient is marked with a marker using a marker pen or a marker using gentian violet as a dye. Gentian violet, also known as gentian violet and gentian violet, is found by american toxicologists to be a dose-related carcinogen, and in vitro cell tests also show that gentian violet can cause mutations and chromosome breakage, but these toxicities are mainly based on long-term oral tests, and thus gentian violet is usually prohibited from being taken orally. Under normal external skin application, the dosage of gentian violet is low and it is difficult to enter the body, so external skin application is not completely prohibited. However, when the marker pen using gentian violet as a dye is used for marking a place where a patient needs to be operated, gentian violet may be brought into the patient during an operation, which may cause a certain risk to the health of the patient. The dyes of marker pens are mainly made of chemical synthetic substances, and health risks may exist when the marker pens enter human bodies during operations. Thus, there is currently a lack in the art of a safe surgical marker.
Disclosure of Invention
Aiming at the problem that the operation marker pens commonly used in the field can cause certain threat to the health of patients, the invention provides the pen ink which takes the pigment extracted from pure natural plants as the dye and is used for marking on the body surface of the patients during the operation.
The invention provides pen ink for a surgical marking pen, which comprises the following raw materials in parts by weight:
10-25 parts of beet red pigment, 30-50 parts of water, 8-15 parts of chitosan and 2-5 parts of polyvinylpyrrolidone/eicosene copolymer.
Preferably, the pen ink comprises the following raw materials in parts by weight:
15-20 parts of beet red pigment, 35-40 parts of water, 10-12 parts of chitosan and 3-4 parts of polyvinylpyrrolidone/eicosene copolymer.
Preferably, the pen ink further comprises one or two of 2-6 parts of a stabilizer and 1-3 parts of a pH value regulator.
Preferably, the stabilizer comprises one or more of glycerol, sorbate and 1, 3-butanediol;
preferably, the pH adjusting agent comprises one or more of acetic acid, potassium dihydrogen phosphate and citric acid.
Preferably, the pH value of the pen ink is 6-6.5.
The invention also provides a preparation method of the pen ink, which comprises the following steps:
(1) mixing the beet red pigment with water to obtain a beet red pigment solution;
(2) mixing chitosan and polyvinylpyrrolidone/eicosene copolymer to obtain a film-forming agent solution;
(3) under the condition of ultrasound, dropwise adding the betalain solution into the film forming agent solution to obtain pen ink for the surgical marker;
the steps (1) and (2) are not limited in time sequence.
Preferably, the frequency of the ultrasound in the step (3) is 20-30 KHz.
The invention also provides a marking pen for operation, which comprises a pen shell and a pen core, wherein the pen ink in the technical scheme is filled in the pen core.
Compared with the prior art, the technical scheme provided by the invention has at least the following beneficial effects:
1. the pen ink provided by the invention takes the beet red pigment as the dye, the beet red pigment is a water-soluble nitrogen-containing pigment, mainly exists in red beet, pokeberry, dragon fruit, mirabilis jalapa, cockscomb and certain plants of Opuntia, is an edible pigment, is safe even entering human bodies, and does not cause serious health hidden trouble;
2. the pen ink provided by the invention takes chitosan and polyvinylpyrrolidone/eicosene copolymer as composite film forming agents, the chitosan and polyvinylpyrrolidone/eicosene copolymer have film forming property and moisture retention property after being compounded, and can form small vacuoles to coat beet red pigment in the pen ink under the action of ultrasound, so that certain water resistance and mechanical resistance are provided for the pen ink, and the pen ink is prevented from falling off easily.
Detailed Description
The invention provides pen ink for a surgical marking pen, which comprises the following raw materials in parts by weight: 10-25 parts of beet red pigment, 30-50 parts of water, 8-15 parts of chitosan and 2-5 parts of polyvinylpyrrolidone/eicosene copolymer. Preferably, the method comprises the following steps: 15-20 parts of beet red pigment, 35-40 parts of water, 10-12 parts of chitosan and 3-4 parts of polyvinylpyrrolidone/eicosene copolymer.
In the invention, the beet red pigment is a dye, is an edible pigment from a pure natural source, and has almost no threat to the health of patients; the beet red pigment can provide red or yellow, the beet red pigment with beet red sweet as main component is purple red, and the beet red pigment with beet flavin I, beet flavin II and cactus yellow as main component is yellow. Since the betalain is an extract of natural substances, the impurities are more, and the betalain is in a mixture state, but the betalain from various sources is in the protection scope of the invention.
In the invention, the water is a solvent of the beet red pigment and is used for dissolving the water-soluble beet red pigment. In the invention, the chitosan and the polyvinylpyrrolidone/eicosene copolymer are both film forming agents, and after the chitosan and the polyvinylpyrrolidone/eicosene copolymer are compounded in the proportion limited by the invention, the chitosan and the polyvinylpyrrolidone/eicosene copolymer can be synergized, and have better moisture retention and film forming properties. In the present invention, the mass ratio of the chitosan to the polyvinylpyrrolidone/eicosene copolymer is preferably 10: 4.
In the invention, the pen ink preferably further comprises one or two of 2-6 parts of a stabilizer and 1-3 parts of a pH value regulator. The stabilizers of the present invention are useful for stabilizing dye states and extending shelf life and include, but are not limited to, one or more of glycerol, sorbate, and 1, 3-butanediol. The pH value regulator disclosed by the invention is used for maintaining the pH value of the pen ink at subacidity (6-6.5), and is beneficial to prolonging the retention time of the pen ink on the skin. The pH regulator of the present invention includes, but is not limited to, one or more of acetic acid, potassium dihydrogen phosphate and citric acid. In the invention, the pH value of the pen ink is 6-6.5.
The invention also provides a preparation method of the pen ink, which comprises the following steps:
(1) mixing the beet red pigment with water to obtain a beet red pigment solution;
(2) mixing chitosan and polyvinylpyrrolidone/eicosene copolymer to obtain a film-forming agent solution;
(3) under the condition of ultrasound, dropwise adding the betalain solution into the film forming agent solution to obtain pen ink for the surgical marker;
the steps (1) and (2) are not limited in time sequence.
In the invention, the frequency of the ultrasound in the step (3) is preferably 20-30 KHz, and more preferably 25-28 KHz; the temperature of the ultrasound is preferably 35-45 ℃.
In the invention, if the pen ink further comprises a stabilizer and/or a pH value regulator, after obtaining the beet red pigment solution, the stabilizer and/or the pH value regulator is dissolved in the beet red pigment solution, and then the solution is dripped into the film forming agent solution after being dissolved.
The invention also provides a marking pen for operation, which comprises a pen shell and a pen core, wherein the pen ink in the technical scheme is filled in the pen core. The structure of the pen shell and the pen core is not particularly limited, and any marking pen capable of filling the pen ink of the invention in the field is within the protection scope of the invention.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
EXAMPLE 1 preparation of Pen ink
(1) Mixing 10g of beet red pigment with 30g of water to obtain a beet red pigment solution;
(2) mixing 10g of chitosan and 3g of polyvinylpyrrolidone/eicosene copolymer to obtain a film forming agent solution;
(3) under the conditions of 30KHz and 35 ℃ ultrasound, the betalain solution is dropwise added into the film forming agent solution to obtain the pen ink for the surgical marker.
EXAMPLE 2 preparation of Pen ink
(1) Mixing 25g of beet red pigment with 50g of water to obtain a beet red pigment solution;
(2) mixing 8g of chitosan and 4g of polyvinylpyrrolidone/eicosene copolymer to obtain a film forming agent solution;
(3) under the conditions of 26KHz and 40 ℃ ultrasound, the betalain solution is dropwise added into the film forming agent solution to obtain the pen ink for the surgical marker.
EXAMPLE 3 preparation of the inks
(1) Mixing 15g of beet red pigment with 40g of water to obtain a beet red pigment solution;
(2) mixing 12g of chitosan and 3g of polyvinylpyrrolidone/eicosene copolymer to obtain a film forming agent solution;
(3) under the conditions of 28KHz and 45 ℃ ultrasound, the betalain solution is dropwise added into the film forming agent solution to obtain the pen ink for the surgical marker.
EXAMPLE 4 preparation of Pen ink
(1) Mixing 10g of beet red pigment with 30g of water to obtain a beet red pigment solution;
(2) mixing the beet red pigment solution with 3g of glycerol, and adjusting the pH value to 6.5 by using acetic acid to obtain a composite beet red pigment solution;
(3) mixing 10g of chitosan and 3g of polyvinylpyrrolidone/eicosene copolymer to obtain a film forming agent solution;
(4) and (3) under the ultrasonic conditions of 30KHz and 35 ℃, dropwise adding the composite betalain pigment solution into the film forming agent solution to obtain the pen ink for the surgical marker.
Example 5
The markers 1 to 4 for operation were obtained by filling the inks prepared in examples 1 to 4 into refills of a marker pen, respectively.
Comparative example
Mixing 10g of beet red pigment with 30g of water to obtain a beet red pigment solution; and filling the beet red pigment solution into a refill of the marker pen to obtain the marker pen of the control group.
Example 6
The surgical markers 1 to 4 prepared in example 5 and the control marker prepared in comparative example were applied to the arm of the same volunteer in an area of 2cm × 2cm for 30min and then rinsed with water for 1 min. The results show that the areas coated with the control marker were easily washed away, while the areas coated with the surgical markers 1-4 were lighter in color but were not completely washed away. And during the continuous flushing for 10min, the areas smeared by the marking pens 1-4 for the operation are completely washed away.
The test shows that the marking pen for the operation has a certain waterproof function.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. The pen ink for the surgical marking pen is characterized by comprising the following raw materials in parts by weight:
10-25 parts of beet red pigment, 30-50 parts of water, 8-15 parts of chitosan and 2-5 parts of polyvinylpyrrolidone/eicosene copolymer.
2. The pen ink as claimed in claim 1, wherein the pen ink comprises the following raw materials in parts by weight:
15-20 parts of beet red pigment, 35-40 parts of water, 10-12 parts of chitosan and 3-4 parts of polyvinylpyrrolidone/eicosene copolymer.
3. The pen ink according to claim 1 or 2, further comprising one or both of 2 to 6 parts of a stabilizer and 1 to 3 parts of a pH adjuster.
4. The pen ink according to claim 3, wherein the stabilizer comprises one or more of glycerin, sorbate, and 1, 3-butanediol.
5. The pen ink according to claim 3, wherein the pH adjusting agent comprises one or more of acetic acid, potassium dihydrogen phosphate, and citric acid.
6. The pen ink according to claim 3, wherein the pH value of the pen ink is 6 to 6.5.
7. A method for preparing the pen ink of any one of claims 1 to 6, comprising the steps of:
(1) mixing the beet red pigment with water to obtain a beet red pigment solution;
(2) mixing chitosan and polyvinylpyrrolidone/eicosene copolymer to obtain a film-forming agent solution;
(3) under the condition of ultrasound, dropwise adding the betalain solution into the film forming agent solution to obtain pen ink for the surgical marker;
the steps (1) and (2) are not limited in time sequence.
8. The preparation method according to claim 7, wherein the frequency of the ultrasound in the step (3) is 20 to 30 KHz.
9. A marking pen for surgery, comprising a pen case and a pen core, wherein the pen ink according to any one of claims 1 to 6 is filled in the pen core.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911064022.3A CN110713752A (en) | 2019-11-04 | 2019-11-04 | Pen ink for surgical marking pen and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911064022.3A CN110713752A (en) | 2019-11-04 | 2019-11-04 | Pen ink for surgical marking pen and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110713752A true CN110713752A (en) | 2020-01-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911064022.3A Pending CN110713752A (en) | 2019-11-04 | 2019-11-04 | Pen ink for surgical marking pen and preparation method thereof |
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| Country | Link |
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| CN (1) | CN110713752A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101171313A (en) * | 2005-05-13 | 2008-04-30 | 伊梅杰公司 | Ingestible or nutritional liquid ink composition for ink jet printing |
| CN101709184A (en) * | 2009-12-02 | 2010-05-19 | 武汉大学 | Edible antibacterial ink |
| US20140271757A1 (en) * | 2011-05-24 | 2014-09-18 | Agienic, Inc., | Antimicrobial compositions for use in products for petroleum extraction, personal care, wound care and other applications |
| CN107109093A (en) * | 2015-01-07 | 2017-08-29 | 白金万年笔株式会社 | Surgical marker ink |
-
2019
- 2019-11-04 CN CN201911064022.3A patent/CN110713752A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101171313A (en) * | 2005-05-13 | 2008-04-30 | 伊梅杰公司 | Ingestible or nutritional liquid ink composition for ink jet printing |
| CN101709184A (en) * | 2009-12-02 | 2010-05-19 | 武汉大学 | Edible antibacterial ink |
| US20140271757A1 (en) * | 2011-05-24 | 2014-09-18 | Agienic, Inc., | Antimicrobial compositions for use in products for petroleum extraction, personal care, wound care and other applications |
| CN107109093A (en) * | 2015-01-07 | 2017-08-29 | 白金万年笔株式会社 | Surgical marker ink |
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Application publication date: 20200121 |