CN110711278A - Blood circulation type bilirubin decomposition device - Google Patents
Blood circulation type bilirubin decomposition device Download PDFInfo
- Publication number
- CN110711278A CN110711278A CN201910990549.2A CN201910990549A CN110711278A CN 110711278 A CN110711278 A CN 110711278A CN 201910990549 A CN201910990549 A CN 201910990549A CN 110711278 A CN110711278 A CN 110711278A
- Authority
- CN
- China
- Prior art keywords
- blood
- decomposition
- blood circulation
- bilirubin
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0621—Hyperbilirubinemia, jaundice treatment
Abstract
The invention discloses a blood circulation type bilirubin decomposition device which comprises a blood circulation pipeline and a heart-lung machine, wherein the heart-lung machine is connected to the blood circulation pipeline, the blood circulation pipeline is provided with a first inlet and a first outlet, the bilirubin decomposition device further comprises a decomposition light source and a light-permeable decomposition container, the decomposition container is provided with a second inlet and a second outlet, the second inlet and the second outlet are connected to the blood circulation pipeline, and the decomposition light source is set to irradiate towards the decomposition container. The blood of the patient flows in the circulating pipeline under the action of the artificial heart-lung machine, and after the blood enters the decomposition container, the bilirubin in the blood is decomposed due to the irradiation of the decomposition light, so that the content of the bilirubin in the blood is effectively reduced. By adopting the mode, the optical fiber directly irradiates blood without separating tissues such as human skin, and the efficiency of decomposing bilirubin is high. And the blood circulation mode adopts the blood of the patient, reduces the consumption of blood resources and can avoid the risk of allogenic blood transfusion.
Description
Technical Field
The invention relates to a medical instrument, in particular to a blood circulation type bilirubin decomposition device.
Background
Jaundice is the most common clinical problem in the neonatal period, and is yellow-stained skin, sclera and other organs due to bilirubin accumulation in the body. Unconjugated bilirubin increase is the most common manifestation of neonatal jaundice, and serious patients can cause bilirubin encephalopathy, cause permanent damage to the nervous system, such as cerebral palsy, intelligence lag, epilepsy, impaired visual and auditory abilities and the like, and can seriously cause death.
Phototherapy, known as phototherapy, is a simple and effective method for reducing the amount of unbound bilirubin in the blood. The principle is that under the action of phototherapy, unconjugated bilirubin is photoisomerized to form water-soluble conformational isomers and structural isomers; the water soluble isomer has no neurotoxicity, and can be directly excreted out of the body via bile and urine without liver treatment. Phototherapy is mainly applied to skin superficial tissues, and the reduction of skin jaundice after phototherapy does not indicate that blood unbound bilirubin has fallen to a safe value; high concentration of unbound bilirubin in the blood can slowly permeate to the superficial skin and be removed from the body by phototherapy, gradual photoisomerization. Thus, a general degree of jaundice can be gradually reduced by phototherapy to a blood unbound bilirubin level. However, severe neonatal jaundice has high unconjugated bilirubin concentration in blood, and is likely to enter the brain, causing irreversible damage to the nervous system and causing bilirubin encephalopathy; phototherapy is not rapid enough to reduce unbound bilirubin in the blood for the treatment of severe jaundice. The severe jaundice infant needs to rapidly reduce the level of unconjugated bilirubin in blood, often needs to be treated by changing blood, the blood consumption of the treatment by changing blood is large, certain blood source waste is caused, certain time is needed for adjusting the blood source, and in addition, the change blood also has potential risk of infecting blood-borne diseases for patients.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a blood circulation type bilirubin decomposition device which can quickly reduce the content of bilirubin in blood.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a blood circulation formula bilirubin decomposition device, includes blood circulation pipeline and artificial heart lung machine, and artificial heart lung machine connects on the blood circulation pipeline, is provided with first entry and first export on the blood circulation pipeline, still includes the decomposition container of decomposition light source and light-permeable, is provided with second entry and second export on the decomposition container, and second entry and second exit linkage are on the blood circulation pipeline, and the decomposition light source is set up to shine towards the decomposition container.
As a further improvement of the invention, the decomposition container is a flat cavity.
As a further improvement of the invention, the decomposition container is cylindrical, an annular decomposition cavity is arranged in the decomposition container, and the decomposition light source is arranged at the center of the decomposition container.
As a further improvement of the invention, a bilirubin detector is disposed in the blood circulation circuit adjacent the first outlet.
As a further improvement of the invention, the blood circulation device also comprises an insulation box, and the blood circulation pipeline is arranged in the insulation box.
A method for decomposing bilirubin in blood comprises
The method comprises the following steps: the blood is subjected to extracorporeal circulation and introduced into a decomposition vessel,
step two: irradiating the blood in the decomposition container with a decomposition light source,
step three: the treated blood was reinjected.
The invention has the advantages that the blood of a patient flows in the circulating pipeline under the action of the artificial heart-lung machine, and the bilirubin in the blood is decomposed due to the irradiation of the decomposition light after the blood enters the decomposition container, thereby effectively reducing the content of the bilirubin in the blood. The artificial heart-lung machine can effectively control various factors in blood, thereby avoiding the damage of the blood external circulation to human body. By adopting the mode, the optical fiber directly irradiates blood without separating tissues such as human skin, and the efficiency of decomposing bilirubin is high. And the blood circulation mode adopts the blood of the patient, reduces the consumption of blood resources and can avoid the risk of allogenic blood transfusion.
Drawings
FIG. 1 is an overall block diagram of the present invention;
fig. 2 is a schematic view of a cylindrical decomposition vessel.
Detailed Description
The invention will be further described in detail with reference to the following examples, which are given in the accompanying drawings.
Referring to fig. 1 and 2, a blood circulation type bilirubin decomposition device of the present embodiment includes a blood circulation line 1 and a heart-lung machine 2, the heart-lung machine 2 is connected to the blood circulation line 1, the blood circulation line 1 is provided with a first inlet 11 and a first outlet 12, and further includes a decomposition light source 3 and a light-permeable decomposition container 4, the decomposition container 4 is provided with a second inlet 41 and a second outlet 42, the second inlet 41 and the second outlet 42 are connected to the blood circulation line 1, and the decomposition light source 3 is configured to irradiate toward the decomposition container 4.
When the device is used, the machine is preheated, the first inlet is connected to the artery, the first outlet is connected to the vein, the device is started, blood of a patient flows in the circulating pipeline under the action of the artificial heart-lung machine, and after the blood enters the decomposition container, bilirubin in the blood is decomposed due to irradiation of decomposition light, so that the content of bilirubin in the blood is effectively reduced. The artificial heart-lung machine can effectively control various factors in blood, thereby avoiding the damage of the blood external circulation to human body. By adopting the mode, the optical fiber directly irradiates blood without separating tissues such as human skin, and the efficiency of decomposing bilirubin is high. And the blood circulation mode adopts the blood of the patient, reduces the consumption of blood resources and can avoid the risk of allogenic blood transfusion.
As a modified specific embodiment, the decomposition container 4 is a flat cavity.
As a modified specific embodiment, the decomposition container 4 is cylindrical, the decomposition chamber 43 having a ring shape is provided in the decomposition container 4, and the decomposition light source 3 is provided at the center of the decomposition container 4.
The decomposition container is arranged to be a flat cavity or a cylinder, so that the area of unit blood receiving illumination is increased, the blood volume required by extracorporeal circulation is reduced, and the injury of the extracorporeal circulation to a human body is reduced.
As a modified embodiment, a bilirubin detector is provided in the blood circulation circuit 1 near the first outlet 12.
The bilirubin detector detects the bilirubin content of the treated blood, and when the bilirubin content is too high, the bilirubin can be decomposed in an accelerated manner by slowing down the flow rate or enhancing the illumination intensity; when the bilirubin content is too low, bilirubin decomposition can be slowed down by increasing the flow rate or by reducing the intensity of light. Through the steps, the content of bilirubin in blood can be ensured to be in a normal range, and overhigh or overlow bilirubin is avoided.
As a modified specific embodiment, the blood circulation device further comprises an insulation box 5, and the blood circulation pipeline 1 is arranged in the insulation box 5.
Through the setting of insulation can, can avoid the blood temperature of reinjection too high or low excessively, harm the human body.
The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (6)
1. The utility model provides a blood circulation formula bilirubin decomposition device, includes blood circulation pipeline (1) and artificial heart lung machine (2), artificial heart lung machine (2) are connected on blood circulation pipeline (1), be provided with first entry (11) and first export (12) on blood circulation pipeline (1), its characterized in that: the blood circulation decomposition device is characterized by further comprising a decomposition light source (3) and a light-permeable decomposition container (4), wherein a second inlet (41) and a second outlet (42) are formed in the decomposition container (4), the second inlet (41) and the second outlet (42) are connected to the blood circulation pipeline (1), and the decomposition light source (3) is arranged to irradiate towards the decomposition container (4).
2. The device for decomposing bilirubin of the blood circulation type according to claim 1, wherein: the decomposition container (4) is a flat cavity.
3. The device for decomposing bilirubin of the blood circulation type according to claim 1, wherein: the decomposition container (4) is cylindrical, an annular decomposition cavity (43) is arranged in the decomposition container (4), and the decomposition light source (3) is arranged at the center of the decomposition container (4).
4. The device for decomposing bilirubin of the blood circulation type according to claim 1, wherein: a bilirubin detector is arranged on the blood circulation pipeline (1) close to the first outlet (12).
5. The device for decomposing bilirubin of the blood circulation type according to claim 1, wherein: the blood circulation device is characterized by further comprising an insulation box (5), wherein the blood circulation pipeline (1) is arranged in the insulation box (5).
6. A method for decomposing bilirubin in blood is characterized in that: comprises that
The method comprises the following steps: the blood is subjected to extracorporeal circulation and introduced into a decomposition vessel (4),
step two: irradiating the blood in the decomposition vessel (4) with a decomposition light source (3),
step three: the treated blood was reinjected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910990549.2A CN110711278A (en) | 2019-10-17 | 2019-10-17 | Blood circulation type bilirubin decomposition device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910990549.2A CN110711278A (en) | 2019-10-17 | 2019-10-17 | Blood circulation type bilirubin decomposition device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110711278A true CN110711278A (en) | 2020-01-21 |
Family
ID=69211880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910990549.2A Pending CN110711278A (en) | 2019-10-17 | 2019-10-17 | Blood circulation type bilirubin decomposition device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110711278A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1572332A (en) * | 2003-05-30 | 2005-02-02 | 富瑞森尼尔斯医护德国有限公司 | Device for extracorporal irradiation of a liquid containing bilirubin, and method therefor |
| US20090131771A1 (en) * | 2005-07-01 | 2009-05-21 | Yoshimasa Takeda | Apparatus For Denaturating Bilirubin And Bilirubin Dialyzer |
| US20130345614A1 (en) * | 2012-06-22 | 2013-12-26 | Viraj P. Mane | Device for extracorporeal photo-isomerization for hyperbilirubinemia, and method thereof |
| CN104548233A (en) * | 2013-10-23 | 2015-04-29 | 国医华科（深圳）医疗科技发展有限公司 | Blood irradiator |
| CN206391261U (en) * | 2016-09-20 | 2017-08-11 | 新乡医学院第三附属医院 | A kind of blood purification medical treatment equipment |
| CN107929840A (en) * | 2017-11-09 | 2018-04-20 | 广州星顿医疗科技有限公司 | A kind of external red light irradiation therapeutic equipment |
-
2019
- 2019-10-17 CN CN201910990549.2A patent/CN110711278A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1572332A (en) * | 2003-05-30 | 2005-02-02 | 富瑞森尼尔斯医护德国有限公司 | Device for extracorporal irradiation of a liquid containing bilirubin, and method therefor |
| US20090131771A1 (en) * | 2005-07-01 | 2009-05-21 | Yoshimasa Takeda | Apparatus For Denaturating Bilirubin And Bilirubin Dialyzer |
| US20130345614A1 (en) * | 2012-06-22 | 2013-12-26 | Viraj P. Mane | Device for extracorporeal photo-isomerization for hyperbilirubinemia, and method thereof |
| CN104548233A (en) * | 2013-10-23 | 2015-04-29 | 国医华科（深圳）医疗科技发展有限公司 | Blood irradiator |
| CN206391261U (en) * | 2016-09-20 | 2017-08-11 | 新乡医学院第三附属医院 | A kind of blood purification medical treatment equipment |
| CN107929840A (en) * | 2017-11-09 | 2018-04-20 | 广州星顿医疗科技有限公司 | A kind of external red light irradiation therapeutic equipment |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7846121B2 (en) | Device for extracorporeal irradiation of a liquid containing bilirubin, and method therefor | |
| CN105726190B (en) | A kind of impulse ultrasound therapeutic equipment for male erectile dysfunction | |
| BRPI0414455A (en) | Methods for Using Regenerative Cells to Treat Peripheral Vascular Disease and Related Disorders | |
| CN105999440B (en) | Intelligence control wet combustion treatment of scald system | |
| CN110711278A (en) | Blood circulation type bilirubin decomposition device | |
| US20130345614A1 (en) | Device for extracorporeal photo-isomerization for hyperbilirubinemia, and method thereof | |
| Zhao et al. | A study of neonatal swimming (water therapy) applied in clinical obstetrics | |
| RU91869U1 (en) | NOSE APPLICATOR FOR INTRASASAL BLOOD IRRADIATION BY A LASER | |
| CA2271190A1 (en) | Improved method for treating mammals with modified mammalian blood | |
| CN203935458U (en) | A kind of hemodialysis system | |
| Abdukarimovich | USE OF PHOTODYNAMIC THERAPY IN CHEMICAL BURNS OF DIFFERENT ETIOLOGIES OF THE SURFACE OF THE EYE | |
| RU2406549C1 (en) | Method of complex spermatogenesis stimulation | |
| RU2565656C2 (en) | Body detoxification method and device | |
| CN110711277A (en) | Blood bilirubin decomposition device | |
| JP3124006U (en) | Hemodialysis machine | |
| RU2475276C1 (en) | Method of treating obliterating atherosclerosis of arteries of lower extremities | |
| RU2269326C1 (en) | Photodynamic method for treating infectious corneal ulcers | |
| RU2364431C1 (en) | Method of systemic endovenous photodynamic therapy of alveolar disease of liver | |
| CN104042374B (en) | Abdominal dropsy internal-drainage one-way support | |
| RU2093216C1 (en) | Method for treatment of blood | |
| CN107029215A (en) | A kind of stem cell medicine and its preparation method and application | |
| RU1792717C (en) | Method for treating arterial hypertension | |
| CN204932625U (en) | A kind of novel blue-light treatment instrument | |
| RU2232014C1 (en) | Method for treating sensoneural impaired hearing | |
| RU2181606C2 (en) | Method for prevention of pyo-septic complications of cardiosurgical patients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200121 |
|
| RJ01 | Rejection of invention patent application after publication |