CN110711218A - Traditional Chinese medicine composition for treating throat pain and cough - Google Patents
Traditional Chinese medicine composition for treating throat pain and cough Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating throat pain and cough. The Chinese medicinal composition comprises radix astragali, fructus forsythiae and mume fructus. Adding conventional adjuvants, and making into tablet, granule, capsule, powder, soft capsule, dripping pill, etc. by conventional method. The traditional Chinese medicine composition has remarkable effect of treating the throat pain and the cough caused by various reasons and has no side effect.
Description
Technical Field
The invention relates to a new application of a traditional Chinese medicine composition containing astragalus, forsythia and dark plum. Belongs to the field of pharmaceutical preparation.
Background
Since the applicant published application numbers: 201510582314.1, title of the invention: a traditional Chinese medicine composition for treating allergic rhinitis and skin allergy is found to have a very good treatment effect on throat pain and cough caused by various reasons while treating allergic rhinitis for more patients in clinics. The search literature finds that according to the Chinese pharmacopoeia dark plum: astringe lung, astringe intestine, promote fluid production and relieve ascaris. Can be used for treating lung deficiency, chronic cough, chronic dysentery, intestine dryness, asthenia heat, diabetes, ascariasis, emesis, abdominal pain, and biliary ascariasis. Chinese patent document discloses application numbers: 201410733076.5, title of the invention: a Chinese medicinal composition for treating pharynx itch and cough comprises the following Chinese medicines: 15-25 g of astragalus root, 8-12 g of dittany bark, 5-10 g of white atractylodes rhizome, 5-10 g of cicada slough, 5-10 g of divaricate saposhnikovia root, 5-10 g of szechuan lovage rhizome and 5-10 g of dark plum fruit. Chinese patent literature also discloses application numbers: 201210281723.4, title of the invention: a traditional Chinese medicine for treating infantile cough by utilizing roughhaired holly root is prepared from the following medicines of 8-12 parts of bulbus fritilariae, 4-8 parts of radix astragali, 1-5 parts of folium eriobotryae, 13-17 parts of dried orange peel, 4-8 parts of dark plum, 4-8 parts of pinellia ternate, 8-12 parts of platycodon grandiflorum, 4-8 parts of radix stemonae, 8-12 parts of fructus kochiae, 1-5 parts of cortex mori, 8-12 parts of fructus schizandrae, 13-17 parts of radix ophiopogonis, 1-5 parts of herba hyperici japonici, 13-17 parts of. Chinese patent literature also discloses application numbers: 201110432757.4, title of the invention: a traditional Chinese medicine effective part composition for treating cough and a preparation method thereof are disclosed, wherein the traditional Chinese medicine effective part composition is composed of platycodon grandiflorum, dark plum, bighead atractylodes rhizome and schizonepeta.
Disclosure of Invention
The technical scheme of the invention is realized as follows: the composition or the raw material medicine of the pharmaceutical composition comprises a combined preparation of astragalus, forsythia and dark plum with a clinically reasonable dose. The proportion of the components or the composition of the raw material medicines of the pharmaceutical composition comprises: 3-30 parts of astragalus; 1-20 parts of fructus forsythiae; 3-40 parts of dark plum.
Wherein the fructus forsythiae can be replaced by fructus forsythiae extract; the radix astragali can be replaced by radix astragali extract; the Saviae Miltiorrhizae radix can be replaced by Saviae Miltiorrhizae radix extract; the other is similar.
The traditional Chinese medicine raw materials are prepared into pharmaceutically acceptable dosage forms including but not limited to decoction, oral liquid, capsules, tablets, granules, dripping pills or powder preparations by adding or not adding conventional auxiliary materials according to a conventional method.
The preparation method of the traditional Chinese medicine composition is a preparation prepared from the raw materials by using different processes and different extraction methods to obtain a mixture of extracts of various medicines, or a mixture of extracts obtained by respectively extracting the medicines into a plurality of different components, or a total extract.
The traditional Chinese medicine composition is any one of the dosage forms in pharmaceutics prepared from the raw materials in the weight ratio, and comprises decoction, oral liquid, powder, tablets, capsules, dispersible tablets, pellets, dripping pills, injection and granules.
The preparation method of the traditional Chinese medicine composition comprises the steps of directly cutting the traditional Chinese medicine raw materials into small pieces or crushing the traditional Chinese medicine raw materials into coarse powder, extracting the obtained medicine extracts by water or ethanol, or continuously concentrating the medicine extracts into dry extract, or mixing the medicine extracts with a pharmaceutically acceptable carrier.
The preparation method of the traditional Chinese medicine composition provided by the invention comprises the steps of decocting the traditional Chinese medicine raw materials with water for 1-3 times, 10-30 minutes each time, filtering, combining the filtrates, and concentrating the filtrate under reduced pressure until the volume of each 1 ml of the filtrate is 1 g of the crude medicine, thus obtaining decoction; or sterilizing, and bottling to obtain oral liquid; or concentrating, drying to obtain dry extract, adding starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate by conventional method, mixing, tabletting, and coating to obtain tablet; or adding conventional excipient, and making into capsule. Or: soaking the traditional Chinese medicine raw materials in ethanol for 8-12 hours, refluxing for 1-3 times by using 75-85% ethanol in an amount which is 20-25 times of the weight of the traditional Chinese medicine raw materials, refluxing for 1-1.5 hours after slight boiling each time, filtering, and recovering the ethanol until no ethanol smell exists to obtain an extract; making into decoction, oral liquid, granule, tablet, pill, powder, injection or capsule by conventional method.
The preparation method of the traditional Chinese medicine composition is preferably that forsythia, astragalus and dark plum are decocted for 3 times by water, 20 minutes are carried out each time, the filtration is carried out, the filtrates are combined, the filtrate is concentrated to 1/2 volumes, and the concentration is carried out under reduced pressure until each 1 milliliter of the filtrate is equivalent to 1 gram of the crude drugs, so that decoction is obtained; or sterilizing, and bottling to obtain oral liquid; or concentrating into soft extract, drying under reduced pressure to obtain dry extract, adding starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or mixing magnesium stearate, tabletting, and coating to obtain tablet; or adding excipient, and encapsulating to obtain capsule.
Or soaking fructus forsythiae, radix astragali and fructus mume in ethanol for 12 hr, refluxing with 25 times of 75-85% ethanol for 2 times, slightly boiling each time, refluxing for 1-1.5 hr, filtering, and recovering ethanol until no ethanol smell exists to obtain extract; making into decoction, oral liquid, granule, tablet, and capsule by the above method.
Or extracting fructus forsythiae, mume fructus, and radix astragali respectively by conventional extraction method. Mixing the extracts. Making into decoction, oral liquid, granule, tablet, and capsule by the above method.
The preparation method of the traditional Chinese medicine composition is preferably that forsythia, astragalus and dark plum are decocted for 3 times by water, 20 minutes are carried out each time, the filtration is carried out, the filtrates are combined, the filtrate is concentrated to 1/2 volumes, and the concentration is carried out under reduced pressure until each 1 milliliter of the filtrate is equivalent to 1 gram of the crude drugs, so that decoction is obtained; or sterilizing, and bottling to obtain oral liquid; or concentrating into soft extract, drying under reduced pressure to obtain dry extract, adding starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or mixing magnesium stearate, tabletting, and coating to obtain tablet; or adding excipient, and encapsulating to obtain capsule.
Or soaking fructus forsythiae, radix astragali and fructus mume in ethanol for 12 hr, refluxing with 25 times of 75-85% ethanol for 2 times, slightly boiling each time, refluxing for 1-1.5 hr, filtering, and recovering ethanol until no ethanol smell exists to obtain extract; making into decoction, oral liquid, granule, tablet, and capsule by the above method.
Or extracting fructus forsythiae, mume fructus, and radix astragali respectively by conventional extraction method. Mixing the extracts. Making into decoction, oral liquid, granule, tablet, and capsule by the above method.
The traditional Chinese medicine composition is any one of the pharmaceutically acceptable dosage forms prepared from the raw materials in the weight ratio or a pharmaceutically acceptable carrier, and comprises decoction, powder, tablets, capsules, dispersible tablets, pellets, injection, oral liquid and granules.
Pharmaceutically acceptable carriers of the present invention include, but are not limited to: excipients, such as starch and its derivatives, dextrin, calcium hydrogen phosphate, magnesium stearate, silica gel micropowder, etc.; disintegrants, such as sodium carboxymethyl cellulose, hydroxypropyl cellulose, and the like; lubricants, such as magnesium stearate and the like; sugar-coating materials such as sucrose, pulvis Talci, gelatin, pigment, and Cera chinensis; film coating materials, such as gastric water, alcohol coating materials, etc.
The application of the pharmaceutical composition comprises throat pain and can be used for treating cough caused by various reasons.
The following experimental examples serve to further illustrate the invention.
The following test examples and examples further demonstrate, but are not limited to, the present invention:
experimental example 1
Taking the present invention as experimental group 1, experimental samples were prepared according to example 1 below; the control group 1 is seven medicines of astragalus root, cortex dictamni, rhizoma atractylodis macrocephalae, cicada slough, radix sileris, rhizoma ligustici wallichii and dark plum which are prepared into a sample by a conventional method (water decoction and concentration) according to the mixture ratio of the raw materials of the claims, wherein the formula is 201410733076.5; the control group 2 is fifteen medicines of bulbus fritilariae, radix astragali, loquat leaves, dried orange peel, dark plum fruit, pinellia ternate, platycodon grandiflorum, radix stemonae, myrobalan meat, cortex mori radicis, schisandra chinensis, radix ophiopogonis, herba hyperici japonici, roughhaired holly root and leymus chinensis of the formula of patent application No. 201210281723.4, and samples are prepared according to the raw material proportion of the claims and a conventional method (water decoction and concentration); the contrast group 3 is four medicines of platycodon grandiflorum, dark plum, bighead atractylodes rhizome and schizonepeta, which are disclosed in the patent application number 201110432757.4, and samples are prepared according to the raw material proportion and the water extraction and alcohol precipitation method of the claims; the control group 4 was prepared by decocting mume fructus with water and concentrating to obtain a sample.
100 cough patients with or without throat pain and treated with or without antibiotic but without cough relief were randomly selected, and the 100 patients were randomly divided into four groups by the random number table method. Age and gender were approximately comparable.
The curative effect is judged according to the traditional Chinese medicine disease diagnosis curative effect standard issued by the State administration of traditional Chinese medicine, and the diagnosis standard is as follows:
the effect is shown: cough and expectoration symptoms disappear or are obviously relieved, lung auscultation and chest penetration are normal or obviously improved, the lung abnormal change integral value is reduced by more than or equal to 70 percent, and abnormal physicochemical indexes are close to normal.
The method has the following advantages: cough and expectoration are reduced, other symptoms are obviously reduced, the integral value is reduced by 30-69%, and the abnormal physicochemical index is improved.
And (4) invalidation: cough and other symptoms are not obviously changed, the integral value is reduced by less than 30 percent, and abnormal physicochemical indexes are not obviously improved.
The daily medicine taking of the experimental group is converted into 40 g of crude drugs, and the crude drugs are taken in several times; the control group 1 is taken in several times according to the administration method disclosed in the patent, and 87 g of crude drug is replaced daily according to the example 3; the control group 2 is taken according to the administration method disclosed in the patent, and the specific implementation mode is that 124 g of crude drug is taken every day; the control group 3 is taken by 15ml each time according to the administration method disclosed in the patent, and is changed into 0.9 g of crude drug per day according to the example 2; the control group 4 was changed to 40 g of crude drug daily and was administered in portions.
The observation period is 10 days, and the treatment results are as follows:
the analysis was as follows: it can be seen that the curative effects of the experimental group 1, the control group 1 and the control group 2 are good, but the experimental group is obviously superior to the control group 1 and the control group 2, and the number of the medicines in the experimental group and the number of grams (weight) of crude drugs taken per day are obviously lower than those of the control group 1 and the control group 2, which shows that the formula of the invention has obvious progress compared with the control group 1 and the control group 2.
Control 3 was almost invalid, indicating that the data of the examples were erroneous. According to the data published in this document, the applicant has calculated again: the applicant really has no calculation error when the weight of crude drugs is 58g +22g +15g +5g to prepare 5000ml oral liquid, 15ml is taken each time and three times a day, and the weight is converted into the weight of crude drugs per day of 100 ÷ 5000 × 15 × 3 ═ 0.9 (g). That is, the holder of this patent issued the data in error.
The control group 4 has certain effect, but the effect of the experimental group 1 can be said to be that the rolling compaction of the control group 4, and the effect of the combination of the invention is obviously better than that of the dark plum singly used.
Experimental example 2
The applicant prepares a sample by a water extraction and alcohol precipitation method according to 58g of platycodon grandiflorum, 22g of dark plum, 15g of bighead atractylodes rhizome and 5g of schizonepeta according to the proportion of the formula of the control group 3, the medicine taken every day is converted into 40 g of crude drug, the crude drug is taken for several times, and the medicine taken every day is compared with the experiment group 1 again and is converted into 40 g of crude drug. Randomly selecting 20 patients with throat pain and cough, observing for 10 days, and obtaining the following results:
and (4) conclusion: in experiments with similar doses, the effective rate of the experimental group 1 is significantly better than that of the control group 3. The formula of the experimental group 1 is more reasonable.
Typical cases
Case one:
when a certain Liu is in hospital for fever and cough before one month, male and 8-year-old people are treated by western medicines of antipyretic analgesics and antibiotics, and then recovered. After two weeks, fever, cough and expectoration develop. After taking the traditional Chinese medicine prepared in the embodiment 1 of the invention, the disease condition is stable and the children are cured.
Case two:
dong Di (Dong in her), woman (D in her), age 3. The infant is in a hospital for a doctor to see a doctor for a half year before the infant suffers from fever, cold, watery nasal discharge and cough. The hospital can be used for treating the cough by antibiotics and antiviral drugs, the cough can not be cured all the time, the attack is repeated, and the body form is increasingly thin. After the traditional Chinese medicine prepared in the embodiment 2 is used for treatment, the cough is avoided and the body is recovered to be normal after 5 days.
Case three:
guo is a man, aged 48 years old, and throat is painful for three days, the Shuanghuanglian oral liquid taken by the man is ineffective for three days, the watermelon frost spray is ineffective for two days, the traditional Chinese medicine prepared in the embodiment 8 of the invention is given for treatment, and after 2 days, throat pain is healed, and the body is recovered to be normal.
Case four:
zhengsomewhat, female, 30 years old, after taking anti-cold drug and antibiotic cefaclor for five days due to common cold and fever, still cough is still endless, then the traditional Chinese medicine prepared in the embodiment 4 of the invention is given for treatment, and after 3 days, cough stops, and recovery and body recovery are realized.
The samples prepared according to examples 2 to 10 below can achieve the effects of experimental group 1 of experimental example 1.
Example 1
Taking 30 g of fructus forsythiae, 30 g of dark plum fruit and 30 g of radix astragali, filtering each time for 20 minutes, and combining the filtrates. Concentrating under reduced pressure to 1 g per 1 ml corresponding to the crude drug to obtain decoction, or sterilizing by irradiation with cobalt 60, and bottling to obtain oral liquid.
Or further drying the obtained extract concentrate under reduced pressure to obtain dry extract, adding appropriate amount of starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate, mixing, tabletting, and coating to obtain tablet.
Or further drying the obtained extract concentrate under reduced pressure to obtain dry extract, adding appropriate amount of starch, pulverizing, mixing, granulating, drying, and encapsulating to obtain capsule.
Example 2:
decocting 40 g of fructus forsythiae, 20 g of dark plum fruit and 30 g of astragalus root with water for 3 times, each time for 20 minutes, filtering, combining the filtrates, and concentrating the filtrate to 1/5 volumes for later use; concentrating under reduced pressure until each 1 ml is equal to 1 g of crude drug, adding 15g of xylitol, stirring, and making into decoction, or sterilizing by cobalt 60 irradiation, and bottling to obtain oral liquid.
Or making into granule, tablet or capsule by the method of example 1.
Example 3:
decocting 50 g of fructus forsythiae, 30 g of dark plum fruit and 25 g of radix astragali with water for 2 times, each time for 60 minutes, filtering in several times, combining filtrates, concentrating to obtain clear paste with the relative density of 1.20-1.25 (measured at 75-80 ℃), cooling to 40 ℃, slowly adding ethanol under stirring to ensure that the ethanol content reaches 75%, fully stirring, standing for 12 hours, filtering to obtain supernatant, adding an appropriate amount of 75% ethanol into residues, stirring, standing for 12 hours, filtering, combining ethanol solutions, recovering ethanol until no ethanol smell exists, adding 15g of xylitol, adding purified water, stirring until the volume of 1 ml of the mixture is equal to that of raw medicinal materials, stirring to obtain decoction, or sterilizing by irradiating with cobalt 60, and filling into bottles to obtain oral liquid.
Or concentrating under reduced pressure to obtain soft extract, drying at low temperature, pulverizing, adding appropriate amount of starch, mixing (or granulating with ethanol, and drying) and making into granule, tablet or capsule.
Example 4:
soaking 30 g of fructus forsythiae, 50 g of dark plum fruit and 30 g of radix astragali in 20-25 times of 75% ethanol twice for ultrasonic treatment, wherein each soaking is carried out for 24 hours, then carrying out ultrasonic treatment for 1 hour, filtering, and recovering ethanol until no ethanol smell exists, thus obtaining an extract; mixing 15g of xylitol and the extract, and adding a proper amount of distilled water; concentrating under reduced pressure to 1 g per 1 ml, stirring to obtain decoction, or sterilizing by cobalt 60 irradiation, and bottling to obtain oral liquid.
Or making into granule, tablet or capsule by the method of example 1.
Example 5:
soaking 35 g of fructus forsythiae, 40 g of dark plum fruit and 30 g of radix astragali in 20-25 times of 75% ethanol twice for ultrasonic treatment, wherein each soaking is carried out for 24 hours, then carrying out ultrasonic treatment for 1 hour, filtering, and recovering ethanol until no ethanol smell exists, thus obtaining an extract; mixing 15g of xylitol and the extract, and adding a proper amount of distilled water; concentrating under reduced pressure to 1 g per 1 ml, stirring to obtain decoction, or sterilizing by cobalt 60 irradiation, and bottling to obtain oral liquid.
Or making into granule, tablet or capsule by the method of example 1.
Example 6:
soaking 40 g of fructus forsythiae, 40 g of dark plum fruit and 20 g of radix astragali in ethanol for 12 hours, refluxing twice with 20-25 times of 75-85% ethanol, refluxing for 1 hour after each slight boiling, filtering, and recovering ethanol until no ethanol smell exists to obtain an extract; mixing 15g of xylitol and the extract, and adding a proper amount of distilled water; concentrating under reduced pressure to 1 g per 1 ml, stirring to obtain decoction, or sterilizing by cobalt 60 irradiation, and bottling to obtain oral liquid.
Or making into granule, tablet or capsule by the method of example 1.
Example 7:
fructus forsythiae, fructus mume and radix astragali are respectively extracted according to the conventional extraction method of formula granules. The extracts are respectively taken and mixed with 40 g of forsythia suspense raw material, 20 g of dark plum and 20 g of astragalus root. Adding appropriate amount of starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate, mixing, tabletting, and coating to obtain tablet.
Or mixing the above extracts, adding appropriate amount of starch, pulverizing, mixing, granulating, drying, and encapsulating to obtain capsule.
Example 8
Fructus forsythiae, radix paeoniae rubra and radix astragali are respectively extracted according to a conventional extraction method of formula particles. The extracts are respectively taken and mixed with 40 g of forsythia suspense raw material, 50 g of dark plum and 20 g of astragalus root. Adding appropriate amount of starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate, mixing, tabletting, and coating to obtain tablet.
Or mixing the above extracts, adding appropriate amount of starch, pulverizing, mixing, granulating, drying, and encapsulating to obtain capsule.
Example 9
Fructus forsythiae, fructus mume and radix astragali are respectively extracted according to the conventional extraction method of formula granules. The extracts are respectively equal to 40 g of forsythia raw material, 40 g of dark plum fruit and 20 g of astragalus root. Adding appropriate amount of starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate, mixing, tabletting, and coating to obtain tablet.
Or mixing the above extracts, adding appropriate amount of starch, pulverizing, mixing, granulating, drying, and encapsulating to obtain capsule.
Example 10
Fructus forsythiae, fructus mume and radix astragali are respectively extracted according to the conventional extraction method of formula granules. The extracts are respectively taken and mixed with 20 g of forsythia suspense raw material, 30 g of dark plum fruit and 20 g of astragalus root. Adding appropriate amount of starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate, mixing, tabletting, and coating to obtain tablet.
Or mixing the above extracts, adding appropriate amount of starch, pulverizing, mixing, granulating, drying, and encapsulating to obtain capsule.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims; meanwhile, any equivalent changes, modifications and variations of the above embodiments according to the essential technology of the present invention are within the scope of the technical solution of the present invention.
Claims (9)
1. A pharmaceutical composition for treating throat pain and cough is characterized in that the raw materials for preparing the effective components are as follows: 3-30 parts of astragalus; 1-20 parts of fructus forsythiae; 3-40 parts of dark plum.
2. The pharmaceutical composition for treating throat pain and cough according to claim 1, wherein the raw materials for preparing the effective ingredients thereof are:
10 parts of astragalus, 10 parts of fructus forsythiae and 10 parts of dark plum;
8 parts of astragalus, 18 parts of fructus forsythiae and 14 parts of dark plum;
20 parts of astragalus, 10 parts of fructus forsythiae and 10 parts of dark plum;
or 6 parts of astragalus root, 10 parts of forsythia fruit and 24 parts of dark plum fruit.
3. The pharmaceutical composition for treating throat pain and cough according to any one of claims 1 to 2, wherein the cough includes cough due to various causes.
4. A process for the preparation of a pharmaceutical composition according to any one of claims 1-2, characterized in that it comprises: the traditional Chinese medicine raw materials are prepared into pharmaceutically acceptable dosage forms including but not limited to decoction, oral liquid, capsules, tablets, granules, dripping pills or powder preparations by adding or not adding conventional auxiliary materials according to a conventional method.
5. A process for the preparation of a pharmaceutical composition according to any one of claims 1-2, characterized in that it comprises: decocting the Chinese medicinal materials with water for 1-3 times, each for 10-30 min, filtering, mixing filtrates, and concentrating the filtrate under reduced pressure to 1 weight part per 1 ml corresponding to the crude drug to obtain decoction; or sterilizing, and bottling to obtain oral liquid; or concentrating, drying to obtain dry extract, adding starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate by conventional method, mixing, tabletting, and coating to obtain tablet; or adding conventional excipient, and making into capsule.
6. A process for the preparation of a pharmaceutical composition according to any one of claims 1-2, characterized in that it comprises: soaking the traditional Chinese medicine raw materials in ethanol for 8-12 hours, refluxing for 1-3 times by using 75-85% ethanol in an amount which is 20-25 times of the weight of the traditional Chinese medicine raw materials, refluxing for 1-1.5 hours after slight boiling each time, filtering, and recovering ethanol until no ethanol smell exists to obtain an extract; making into decoction, oral liquid, granule, tablet, pill, powder, injection or capsule by conventional method.
7. A process for the preparation of a pharmaceutical composition according to claim 3, characterized in that it comprises: decocting the Chinese medicinal materials with water for 1-3 times, each for 10-30 min, filtering, mixing filtrates, and concentrating the filtrate under reduced pressure to 1 weight part per 1 ml corresponding to the crude drug to obtain decoction; or sterilizing, and bottling to obtain oral liquid; or concentrating, drying to obtain dry extract, adding starch, pulverizing, mixing, sieving with 80 mesh sieve, wet granulating with 95% ethanol, drying below 80 deg.C, grading, and making into granule; or adding magnesium stearate by conventional method, mixing, tabletting, and coating to obtain tablet; or adding conventional excipient, and making into capsule.
8. A process for the preparation of a pharmaceutical composition according to claim 3, characterized in that it comprises: soaking the traditional Chinese medicine raw materials in ethanol for 8-12 hours, refluxing the traditional Chinese medicine raw materials with 20-25 weight times of 75-85% ethanol for two times, refluxing for 1-1.5 hours after slight boiling, filtering, and recovering ethanol until no ethanol smell exists to obtain an extract; making into decoction, oral liquid, granule, tablet, pill, powder, injection or capsule by conventional method.
9. Use of the pharmaceutical composition according to any one of claims 1-2 for the preparation of a medicament for the treatment of sore throat and cough.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810762051.6A CN110711218A (en) | 2018-07-12 | 2018-07-12 | Traditional Chinese medicine composition for treating throat pain and cough |
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| CN201810762051.6A CN110711218A (en) | 2018-07-12 | 2018-07-12 | Traditional Chinese medicine composition for treating throat pain and cough |
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Application publication date: 20200121 |