CN110693900A - Cleaning care solution for cervical erosion - Google Patents
Cleaning care solution for cervical erosion Download PDFInfo
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- CN110693900A CN110693900A CN201911016079.6A CN201911016079A CN110693900A CN 110693900 A CN110693900 A CN 110693900A CN 201911016079 A CN201911016079 A CN 201911016079A CN 110693900 A CN110693900 A CN 110693900A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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Abstract
The invention provides a cleaning care solution for cervical erosion, which is divided into a cleaning solution and a reducing solution, wherein the cleaning solution is prepared by dissolving 2 g of baking soda in 100 ml of distilled water and proportioning into 2% baking soda solution; the reducing solution is prepared by grinding 10 mg of vitamin B2 into powder, and dissolving the powder and 10 mg of sodium chloride in 1ml of distilled water according to the proportion of 1:1 to prepare the oxidant reducing solution. The using method comprises the following steps: expanding uterus to expose cervix uteri, and wiping a rotten surface by dipping a large cotton swab in 2% of cleaning solution; after drying, dipping the reducing liquid with a small cotton swab, directly smearing the reducing liquid and covering the rotten surface, wherein the reducing liquid forms an oxide film after a few minutes; and the operation is finished when the vaginal dilator is taken out. The cleaning care solution disclosed by the invention has the advantages that the oxide film automatically falls off after about 20 days, the operation is simple, the operation is finished in a few minutes, the cervix uteri is not damaged, the operation and the medicine taking are not needed, the daily life is not influenced, and the cleaning care solution is safe and has no toxic or side effect.
Description
Technical Field
The invention belongs to the field of biology, and particularly relates to a cleaning care solution for cervical erosion.
Background
The surface around the external cervical os is occupied by a stretch of the columnar epithelium of the mucosa of the cervical canal, resulting in a red lesion known as cervical erosion. Cervical erosion is usually asymptomatic, and clinically, a large amount of pus-like leucorrhea, vaginal and cervical congestion, tenderness and bleeding appear when inflammation is obvious. A large number of pathogenic bacteria are propagated on the surface of the paste, and the paste has foul odor when rotten seriously. Especially, the cervical cancer is easily induced by infecting HPV virus. If the patient is not treated timely and effectively, the disease condition of the patient is aggravated, the inflammatory reaction further spreads to the uterus, and even serious diseases such as infertility, uterine cancer and the like are caused. The related clinical data show that the prevalence rate of cervical erosion accounts for about 50% of gynecological diseases, so that the research and development of effective products for controlling the disease conditions of patients with cervical erosion are very important.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a cleaning care solution for cervical erosion.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a cleaning care solution for cervical erosion is divided into a cleaning solution and a reducing solution, wherein the cleaning solution is prepared by dissolving 2 g of baking soda in 100 ml of distilled water and proportioning into a 2% baking soda solution; the reducing solution is prepared by grinding 10 mg of vitamin B2 into powder, and dissolving the powder and 10 mg of sodium chloride in 1ml of distilled water according to the proportion of 1:1 to prepare the oxidant reducing solution.
The use method of the cleaning care solution comprises the following steps:
(1) expanding uterus to expose cervix uteri, and wiping a rotten surface with a large cotton swab dipped with 2% of cleaning solution;
(2) after drying, dipping the reducing liquid with a small cotton swab, directly smearing the reducing liquid and covering the rotten surface, wherein the reducing liquid forms an oxide film after a few minutes; and the operation is finished when the vaginal dilator is taken out.
The properties and effects of the raw materials are as follows:
1) baking soda: is acid salt generated after the neutralization of strong base and weak acid, and is dissolved in water to present weak base. The baking soda and distilled water are proportioned into 2 percent solution, which has the function of quickly cleaning and killing vaginal mold and various vaginal pathogenic bacteria;
2) vitamin B2: is a growth promoting factor which is a water-soluble vitamin, is easy to absorb, can participate in biological oxidation and energy metabolism in vivo and is also an oxidant; plays an important role in carbohydrate, protein, nucleic acid and fat metabolism; can promote growth and maintain the integrity of skin and cell membranes;
3) sodium chloride: is an ionic compound, is easy to dissolve in water and has strong stability; cervical erosion is caused by the loss of balance in the concentration of sodium ions in the blood, sodium oxide is indispensable to the human body, and 80% of it is present in extracellular fluid, i.e., in plasma and intercellular fluid; chloride ions are also mainly present in extracellular fluid, and the main function of the chloride ions is to maintain the osmotic pressure of the extracellular fluid and participate in the regulation of acid-base balance in vivo. It has direct killing effect on various microbe pathogenic bacteria and viruses.
Has the advantages that: the oxide film automatically falls off after the cleaning care solution is used for about 20 days, and the cervix is as perfect as before after the repair is finished without scars. The cleaning care solution disclosed by the invention is simple to operate, can be completed in a few minutes, does not injure the cervix, does not need an operation, does not need injection and medicine taking, is not influenced on daily life, and is safe and free of toxic and side effects.
Detailed Description
The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.
A cleaning care solution for cervical erosion is divided into a cleaning solution and a reducing solution, wherein the cleaning solution is prepared by dissolving 2 g of baking soda in 100 ml of distilled water and proportioning into a 2% baking soda solution; the reducing solution is prepared by grinding 10 mg of vitamin B2 into powder, and dissolving the powder and 10 mg of sodium chloride in 1ml of distilled water according to the proportion of 1:1 to prepare the oxidant reducing solution. The use method of the cleaning care solution comprises the following steps:
(1) expanding uterus to expose cervix uteri, and wiping a rotten surface with a large cotton swab dipped with 2% of cleaning solution;
(2) after drying, dipping the reducing liquid with a small cotton swab, directly smearing the reducing liquid and covering the rotten surface, wherein the reducing liquid forms an oxide film after a few minutes; and the operation is finished when the vaginal dilator is taken out. Usually once. If the severity is individually severe, the above operation method is repeated once.
Test example 1: the treatment effect of the cleaning care solution for cervical erosion in the examples was tested
200 cases of cervical erosion patients are selected and grouped by an envelope extraction method. The basic data of the severity, course and age of the disease of each group of cervical erosion patients are compared, and the difference has no statistical significance (P is more than 0.05) and is comparable.
Patients with cervical erosion met the following inclusion and exclusion criteria:
inclusion criteria were: all patients meet the diagnostic standard of 'gynecologic obstetrics', and the diagnosis is cervical erosion; the clinical data is complete; the age is greater than 18 years;
exclusion criteria: 1) patients in gestation or lactation; 2) incomplete clinical data; 3) patients with other serious cardiological complications; 4) abnormal mental system and endocrine system due to blood system disorder; 5) contraindicated in medication.
The treatment method comprises the following steps: the 2 percent cleaning solution is used for disinfecting the vulva, the vagina and the cervix of a patient, wiping vaginal secretion, dipping the reducing solution of the invention by a small cotton swab after drying, directly smearing the reducing solution and covering the rotten surface, and forming an oxide film after a few minutes; the operation is completed after the vaginal dilator is taken out, and the treatment only needs 1 time. The treatment follow-up period was 6 months.
The curative effect index is as follows: observing and recording the total effective rate, the average bleeding time and the wound healing time of each group of cervical erosion patients.
The treatment effect is divided into three types of obvious effect, effective effect and ineffective effect, and the specific judgment standard is as follows: after the treatment, the wound surface of a patient is completely healed, the local cervical mucosa is smooth, the cervical ulcer is avoided, and the treatment effect is obvious when no relapse occurs after 6 months; after treatment, the wound surface of a patient is basically healed, the local mucosa of the cervix is smoother, and the condition of cervical ulcer is obviously improved and is considered to be effective; after treatment of the patient, wound healing and no improvement in clinical symptoms in the patient were considered ineffective. Wherein, the total effective rate is 100% minus the difference of the inefficiency, and the calculation formula of the inefficiency is: the inefficacy is the number of invalid persons/number of test persons x 100%.
The difference of the total effective rate, wound healing time and average bleeding time of each group has statistical significance (P is less than 0.05). The specific test results are shown in table 1.
Table 1: therapeutic effect test meter
Test example 2: evaluation of anti-HPV Positive Effect of the cleaning Care solution for cervical erosion in examples
200 cases of cervical erosion patients are selected and grouped by an envelope extraction method. Compared with basic data such as the severity, the course, the age and the like of the HPV positive patients, the differences have no statistical significance (P is more than 0.05) and are comparable.
Patients with cervical erosion met the following inclusion and exclusion criteria:
inclusion criteria were: all patients meet the diagnostic standard of 'gynaecology and obstetrics science', and are diagnosed as HPV positive with different degrees; the clinical data is complete; the age is greater than 18 years;
exclusion criteria: 1) patients in gestation or lactation; 2) incomplete clinical data; 3) patients with other serious cardiological complications; 4) abnormal mental system and endocrine system due to blood system disorder; 5) contraindicated in medication.
The treatment method comprises the following steps: the 2 percent cleaning solution is used for disinfecting the vulva, the vagina and the cervix of a patient, wiping vaginal secretion, dipping the reducing solution of the invention by a small cotton swab after drying, directly smearing the reducing solution and covering the rotten surface, and forming an oxide film after a few minutes; the operation is completed after the vaginal dilator is taken out, and the operation is performed for 1 time within 7 days after the treatment of each month. The treatment period is 3 months.
The curative effect index is as follows: the hospital reviews the HPV indexes for comparison after three months.
The treatment effect is divided into three types of obvious effect, effective effect and ineffective effect, and the specific judgment standard is as follows: after the patient is treated, all HPV positive indexes are turned negative, and no recurrence is regarded as obvious effect after 6 months of treatment; after treatment, the HPV positive index part turns negative, and the HPV positive index part is regarded as effective; after treatment, the HPV positive indicator is not considered to be valid without any negative conversion. Wherein, the total effective rate is 100% minus the difference of the inefficiency, and the calculation formula of the inefficiency is: the inefficacy is the number of invalid persons/number of test persons x 100%.
The difference of the total effective rate, wound healing time and average bleeding time of each group has statistical significance (P is less than 0.05). The specific test results are shown in table 2.
Table 2: anti-HPV positive virus effect test table
Test example 3: tests on the bacteriostatic performance of the cleaning care solution for cervical erosion in the examples
The test indicator bacteria include Escherichia coli (8099), Staphylococcus aureus (ATCC6538) and Candida albicans (ATCC 10231).
Preparation of bacterial suspension: inoculating the strain on the slant of the culture medium, washing off the lawn on the slant with phosphate buffer solution after culture, mixing uniformly and counting to prepare the bacterial suspension meeting the requirement of bacterial content.
And (3) bacteriostatic test: 5mL of reducing solution (phosphate buffer solution is adopted by a positive control group) for treating cervical erosion and 0.1mL of bacterial suspension are added into a sterile test tube and mixed evenly until the time specified by design is reached. 0.1mL of the well-mixed sample solution is inoculated into a sterile plate, immediately poured into an agar culture medium which is melted and cooled to 45 ℃ and mixed evenly. After solidification, each inoculated plate is placed at 37 ℃ for culturing for 49 hours, the result is observed, and the bacteriostasis rate is calculated.
The calculation formula of the bacteriostatic rate is as follows: the bacteriostatic rate (%) was (average number of bacteria in positive control group-average number of bacteria in experimental group)/average number of bacteria in positive control group × 100%.
The detection shows that the reducing liquid for treating cervical erosion acts on staphylococcus aureus and candida albicans for 15 minutes, and the bacteriostasis rate reaches over 90 percent; the antibacterial effect on the escherichia coli is 25 minutes, and the antibacterial rate is over 90 percent.
Claims (1)
1. A cleaning care solution for cervical erosion is characterized in that: the cleaning solution is prepared by dissolving 2 g of baking soda in 100 ml of distilled water and proportioning into 2% baking soda solution; the reducing solution is prepared by grinding 10 mg of vitamin B2 into powder, and dissolving the powder and 10 mg of sodium chloride in 1ml of distilled water according to the proportion of 1:1 to prepare the oxidant reducing solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911016079.6A CN110693900A (en) | 2019-10-24 | 2019-10-24 | Cleaning care solution for cervical erosion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911016079.6A CN110693900A (en) | 2019-10-24 | 2019-10-24 | Cleaning care solution for cervical erosion |
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| Publication Number | Publication Date |
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| CN110693900A true CN110693900A (en) | 2020-01-17 |
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| CN201911016079.6A Withdrawn CN110693900A (en) | 2019-10-24 | 2019-10-24 | Cleaning care solution for cervical erosion |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1117395A (en) * | 1995-03-25 | 1996-02-28 | 郭海荣 | Compound medicine for treating cervical erosion |
| CN101342137A (en) * | 2008-08-15 | 2009-01-14 | 黄洪弼 | Multifunctional vulva nursing liquid and preparation method thereof |
| US20100152304A1 (en) * | 2008-12-17 | 2010-06-17 | Geng Funeng | Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations |
| CN102178748A (en) * | 2011-04-13 | 2011-09-14 | 姜殿玺 | External medicament for treating ulcer |
| CN102988411A (en) * | 2012-11-27 | 2013-03-27 | 顾月燕 | Preparation method of gynecological lotion |
-
2019
- 2019-10-24 CN CN201911016079.6A patent/CN110693900A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1117395A (en) * | 1995-03-25 | 1996-02-28 | 郭海荣 | Compound medicine for treating cervical erosion |
| CN101342137A (en) * | 2008-08-15 | 2009-01-14 | 黄洪弼 | Multifunctional vulva nursing liquid and preparation method thereof |
| US20100152304A1 (en) * | 2008-12-17 | 2010-06-17 | Geng Funeng | Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations |
| CN102178748A (en) * | 2011-04-13 | 2011-09-14 | 姜殿玺 | External medicament for treating ulcer |
| CN102988411A (en) * | 2012-11-27 | 2013-03-27 | 顾月燕 | Preparation method of gynecological lotion |
Non-Patent Citations (3)
| Title |
|---|
| 刘学华等: "《难治性妇科病辨治与验案》", 28 February 2011, 科学技术文献出版社 * |
| 温辉梁: "《生物化工产品生产技术》", 31 December 2004, 江西科学技术出版社 * |
| 许勉斋: "《勉斋医诀与医化》", 31 May 2018, 中国中医药出版社 * |
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Effective date of registration: 20200426 Address after: Xiangcheng County Mai Ling Zhen ban Jie Lou Cun of Xuchang City, Henan province 461700 Applicant after: Xu Changsen medical biological health industry Co., Ltd Address before: The 3 group of Xiangcheng Mai Ling Zhen ban Jie Lou Cun of Xuchang City, Henan province 461700 Applicant before: Liu Zijun |
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| TA01 | Transfer of patent application right | ||
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Effective date of registration: 20200916 Address after: Xiangcheng County Mai Ling Zhen ban Jie Lou Cun of Xuchang City, Henan province 461700 Applicant after: Liu Zijun Address before: Xiangcheng County Mai Ling Zhen ban Jie Lou Cun of Xuchang City, Henan province 461700 Applicant before: Xu Changsen medical biological health industry Co.,Ltd. |
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Application publication date: 20200117 |