CN110638985A - Chinese medicinal composition gel suppository for treating gynecological inflammation and preparation method thereof - Google Patents
Chinese medicinal composition gel suppository for treating gynecological inflammation and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a traditional Chinese medicine composition gel suppository for treating gynecological inflammation, which comprises the following active components in parts by weight: 3-8 parts of black tea, 3-8 parts of houttuynia cordata, 5-10 parts of radix stemonae, 3-8 parts of lithospermum, 5-10 parts of wormwood, 1-5 parts of ginger, 3-8 parts of motherwort, 5-10 parts of lucid ganoderma, 1-5 parts of mint, 1-5 parts of orange flower, 1-5 parts of purslane and 5-10 parts of dried orange peel. The invention has the following beneficial effects: the traditional Chinese medicine extract to be extracted belongs to plant natural compounds, has wide sources, can be extracted and separated from plant source traditional Chinese medicines, and can also be directly purchased from preparation companies. Compared with the clinical existing chemical drugs, the traditional Chinese medicine composition has obvious curative effect on treating gynecological inflammation, has no irritation, no allergy, no toxic or side effect on skin and mucosa, and has high safety and comfort. Can be clinically applied to the treatment of gynecological inflammations such as trichomonas vaginitis, colpitis mycotica, cervicitis, pelvic inflammation, peculiar smell, pruritus vulvae and the like.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition gel suppository for treating gynecological inflammation and a preparation method thereof.
Background
Gynecological inflammation mainly refers to inflammation of female genital organs, including vaginitis, cervicitis and pelvic inflammation caused by various reasons, symptoms such as pruritus vulvae, burning pain, vaginal congestion, leukorrhagia, sexual intercourse pain, frequent micturition, urgent micturition, pain in urination, lower abdomen distention and the like often appear, and the gynecological inflammation becomes a large disease which troubles modern women. According to the data published by the world health organization, the number of women in childbearing age in China is about 1.5-2 hundred million, wherein about 41 percent of women suffer from gynecological inflammation with different degrees, and the incidence rate of married women is as high as 70 percent. Some patients have more serious illness, more complicated etiology and longer course of disease, and more than 5 percent of women have serious illness and influence normal study, work or life. The medicines for treating gynecological inflammation in the market at present mainly comprise western medicines which have high side effects, can generate drug resistance, are easy to repeat and have poor curative effect.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition gel suppository for treating gynecological inflammation and a preparation method thereof, and the traditional Chinese medicine composition gel suppository has the advantages of obvious curative effect, high cure rate, safety and no toxic or side effect.
In order to achieve the purpose, the invention adopts the technical scheme that
A traditional Chinese medicine composition gel suppository for treating gynecological inflammation comprises the following active components in parts by weight: 3-8 parts of black tea, 3-8 parts of houttuynia cordata, 5-10 parts of radix stemonae, 3-8 parts of lithospermum, 5-10 parts of wormwood, 1-5 parts of ginger, 3-8 parts of motherwort, 5-10 parts of lucid ganoderma, 1-5 parts of mint, 1-5 parts of orange flower, 1-5 parts of purslane and 5-10 parts of dried orange peel.
A preparation method of a traditional Chinese medicine composition gel suppository for treating gynecological inflammation comprises the following steps:
pulverizing the raw materials in corresponding weight parts to obtain extract, adding ethanol solution, reflux extracting, filtering the extractive solution, and recovering ethanol from the filtrate until no ethanol smell is obtained to obtain extract.
Preferably, the concentration of the ethanol solution is 50-90%, and the amount of the added ethanol is 3-7 times of the amount of the corresponding extract to be extracted.
Preferably, the extract is added with 2-10 parts of humectant, 0.1-2 parts of thickening agent and 30-40 parts of purified water, and the pH is adjusted to 4.5-5.5, thus obtaining the traditional Chinese medicine composition gel suppository for treating gynecological inflammation.
Preferably, the humectant is selected from one or both of glycerin and butylene glycol.
Preferably, the thickener is selected from one or more of carbomer, xanthan gum and hydroxymethyl cellulose.
Preferably, the pharmaceutical agent for treating gynecological inflammation comprises a traditional Chinese medicine composition prepared from 3-8 parts of black tea, 3-8 parts of houttuynia cordata, 5-10 parts of radix stemonae, 3-8 parts of lithospermum, 5-10 parts of wormwood, 1-5 parts of ginger, 3-8 parts of motherwort, 5-10 parts of lucid ganoderma, 1-5 parts of mint, 1-5 parts of orange flower, 1-5 parts of purslane and 5-10 parts of dried orange peel. The dosage forms are tablet, capsule, oral liquid and topical preparation.
The working principle of the invention is as follows: the traditional Chinese medicine composition gel suppository has the effects of clearing damp, diminishing inflammation, resisting bacteria, killing insects, relieving itching and eliminating peculiar smell, has no irritation, allergy and toxic or side effect on skin mucosa, and has high safety and comfort. Can be clinically applied to the treatment of gynecological inflammations such as trichomonas vaginitis, colpitis mycotica, cervicitis, pelvic inflammation, peculiar smell, pruritus vulvae and the like.
The invention has the following beneficial effects: the traditional Chinese medicine extract to be extracted belongs to plant natural compounds, has wide sources, can be extracted and separated from plant source traditional Chinese medicines, and can also be directly purchased from preparation companies. Compared with the clinical existing chemical drugs, the traditional Chinese medicine composition has obvious curative effect on treating gynecological inflammation, has no irritation, no allergy, no toxic or side effect on skin and mucosa, and has high safety and comfort. Can be clinically applied to the treatment of gynecological inflammations such as trichomonas vaginitis, colpitis mycotica, cervicitis, pelvic inflammation, peculiar smell, pruritus vulvae and the like.
Detailed Description
The following further describes embodiments of the present invention with reference to examples. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
The technical scheme of the specific implementation of the invention is as follows:
example 1
A traditional Chinese medicine composition gel suppository for treating gynecological inflammation comprises the following components by weight:
black tea (5 parts), cordate houttuynia (5 parts), stemona root (7 parts), lithospermum (5 parts), wormwood (8 parts), ginger (3 parts), motherwort (5 parts), lucid ganoderma (7 parts), mint (3 parts), orange flower (3 parts), purslane (3 parts) and dried orange peel (5 parts).
The preparation method of the gel suppository of the traditional Chinese medicine composition comprises the following steps:
step 1: taking the black tea, the houttuynia cordata, the stemona root, the lithospermum, the wormwood, the ginger, the motherwort, the lucid ganoderma, the mint, the orange flower, the purslane and the dried orange peel in parts by weight, crushing into coarse powder, soaking the coarse powder in 70% ethanol overnight, heating and extracting under reflux for 3 times (2 hours, 1.5 hours and 1 hour), filtering, combining the filtrates, and recovering the ethanol until no alcohol smell exists, thus obtaining the extract of the traditional Chinese medicine composition.
Step 2: and (2) taking the extract extracted in the step (1), diluting with purified water 4 times the amount of the raw medicinal materials, adding propylene glycol (3 parts) and carbomer (3 parts), uniformly stirring, adjusting the pH to 5.5, and preparing into a suppository by a conventional method to obtain the traditional Chinese medicine composition gel suppository for treating gynecological inflammation.
In vitro bacteriostatic activity test:
200 mg of the gel of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation prepared in the embodiment 1 is precisely weighed, sterilized pure water is added for dissolution, the volume is determined to be 10 mL through a volumetric flask, and after the gel test sample is fully shaken up, a gel test sample with the concentration of 20 mg/mL is obtained and is used for a bacteriostatic test.
The in vitro antibacterial test strains are Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 35218) and Candida albicans (ATCC 10231).
Taking out each frozen strain, thawing at room temperature, inoculating the strain on a flat plate prepared according to a culture medium formula provided by a strain preservation center under an aseptic condition, culturing at 37 ℃ for 12 h, selecting a single colony, inoculating the single colony in a corresponding liquid culture medium, culturing at 37 ℃ for 12 h by a shaking table, counting bacteria in a bacterial liquid, and adjusting the concentration of the bacteria to 106 CFU/mL. 0.1 mL of diluted bacterial liquid is uniformly coated on a corresponding culture medium plate, each strain is coated on 3 plates, the antibacterial activity of the prepared gel is detected by the conventional steps of an Oxford cup method, and the experimental results are shown in Table 1.
And (4) conclusion: by measuring the diameter of the inhibition zone, the gel of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation has good antibacterial activity on staphylococcus aureus, escherichia coli and candida albicans.
And (3) bacteriostatic test:
200 mg of the gel of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation in the embodiment 1 is precisely weighed, sterilized pure water is added for dissolution, the volume is determined to be 10 mL through a volumetric flask, and after the gel is fully shaken up, a gel test sample with the concentration of 20 mg/mL is obtained and is used for an antibacterial test.
Taking out each frozen strain, thawing at room temperature, inoculating on a flat plate prepared according to a culture medium formula provided by a strain preservation center under an aseptic condition, culturing at 37 ℃ for 12 h, selecting a single colony, inoculating in a corresponding liquid culture medium, culturing at 37 ℃ for 12 h by a shaking table, counting bacteria in a bacterial liquid, and adjusting the concentration of the bacteria to 4-5 multiplied by 105 CFU/mL.
1 mL of the diluted bacterial suspension and 1 mL of the gel test sample with a concentration of 20 mg/mL were added to 9 sterilized 100 mL flasks, respectively, supplemented with 8 mL of the corresponding liquid medium, shaken, and 3 flasks were inoculated with each bacterium. Meanwhile, each strain was set to 3 replicates of a blank control without the addition of a gel test sample. After culturing for 24 h in a 37 ℃ incubator, the concentration of each bacterial liquid is tested, and the detection results are shown in table 2: the influence of the gel component of the traditional Chinese medicine composition for treating gynecological inflammation on the bacterial liquid concentration of staphylococcus aureus, escherichia coli and candida albicans is shown in the unit (mg/mL).
And (4) conclusion:
the gel components of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation are matched with each other, and have synergistic interaction, so that the inhibition concentration of the traditional Chinese medicine composition gel suppository on staphylococcus aureus, escherichia coli and candida albicans is greatly reduced, and the inhibition rate is greatly increased. Meanwhile, due to the existence of compatibility of the traditional Chinese medicines, the prepared gel for treating gynecological inflammation can also exert unique performances of the components, such as clearing heat, removing dampness, relieving itching and killing parasites, and can treat complications caused by gynecological diseases.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the technical principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (7)
1. A traditional Chinese medicine composition gel suppository for treating gynecological inflammation is characterized in that: the active components of the medicine comprise the following raw material medicines in parts by weight: 3-8 parts of black tea, 3-8 parts of houttuynia cordata, 5-10 parts of radix stemonae, 3-8 parts of lithospermum, 5-10 parts of wormwood, 1-5 parts of ginger, 3-8 parts of motherwort, 5-10 parts of lucid ganoderma, 1-5 parts of mint, 1-5 parts of orange flower, 1-5 parts of purslane and 5-10 parts of dried orange peel.
2. A preparation method of a traditional Chinese medicine composition gel suppository for treating gynecological inflammation is characterized by comprising the following steps: comprises the following steps:
pulverizing the raw materials in parts by weight to obtain extract, adding ethanol solution, reflux extracting, filtering the extractive solution, and recovering ethanol from the filtrate until no ethanol smell is obtained to obtain extract.
3. The preparation method of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation according to claim 2, which is characterized in that: the concentration of the ethanol solution is 50-90%, and the added ethanol is 3-7 times of the corresponding amount of the extract to be extracted.
4. The preparation method of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation according to claim 3, is characterized in that:
adding humectant 2-10 parts, thickener 0.1-2 parts, and purified water 30-40 parts into the extract, and adjusting pH to 4.5-5.5 to obtain the Chinese medicinal composition gel suppository for treating gynecological inflammation.
5. The preparation method of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation according to claim 4, is characterized in that:
the humectant is one or two selected from glycerin and butanediol.
6. The preparation method of the traditional Chinese medicine composition gel suppository for treating gynecological inflammation according to claim 5, is characterized in that:
the thickening agent is selected from one or more of carbomer, xanthan gum and hydroxymethyl cellulose.
7. A pharmaceutical reagent for treating gynecological inflammation is characterized by comprising a traditional Chinese medicine composition prepared from 3-8 parts of black tea, 3-8 parts of houttuynia cordata, 5-10 parts of radix stemonae, 3-8 parts of lithospermum, 5-10 parts of wormwood, 1-5 parts of ginger, 3-8 parts of motherwort, 5-10 parts of lucid ganoderma, 1-5 parts of mint, 1-5 parts of orange flower, 1-5 parts of purslane and 5-10 parts of dried orange peel.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112076353A (en) * | 2020-10-23 | 2020-12-15 | 郑忠根 | Condom with function of treating gynecological inflammation and preparation method thereof |
| CN114632054A (en) * | 2021-04-27 | 2022-06-17 | 山东华中生物科技有限公司 | Microecological regulation composition, gynecological gel and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112076353A (en) * | 2020-10-23 | 2020-12-15 | 郑忠根 | Condom with function of treating gynecological inflammation and preparation method thereof |
| CN114632054A (en) * | 2021-04-27 | 2022-06-17 | 山东华中生物科技有限公司 | Microecological regulation composition, gynecological gel and preparation method thereof |
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