CN110680555A - Nude mouse subcutaneous tumor forming device - Google Patents
Nude mouse subcutaneous tumor forming device Download PDFInfo
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- CN110680555A CN110680555A CN201911100778.9A CN201911100778A CN110680555A CN 110680555 A CN110680555 A CN 110680555A CN 201911100778 A CN201911100778 A CN 201911100778A CN 110680555 A CN110680555 A CN 110680555A
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- frame body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
Abstract
The invention relates to the technical field of medical experimental equipment, and particularly discloses a nude mouse subcutaneous tumor forming device which comprises a positioning frame, a shape limiting unit, an elastic band I and an elastic band II, wherein the positioning frame comprises an upper frame body and a lower frame body, and the upper frame body is detachably connected with the lower frame body; the shape limiting unit comprises two hemispherical cover bodies which can be spliced to form a spherical cavity with an opening at the bottom, each hemispherical cover body is provided with a fixing piece, and the fixing pieces are clamped between the upper frame body and the lower frame body; elastic band I and elastic band II are fixed connection respectively in the both sides of framework down, and the one end fixedly connected with nylon velvet area I of framework is kept away from down to elastic band I, and the one end fixedly connected with nylon hook area of framework is kept away from down to elastic band II. The invention can protect the part after the nude mice are inoculated with the tumor cells and limit the shape of the tumor growth, so that the shape of the tumor is relatively regular, thereby avoiding a great deal of waste of experimental resources and reducing the labor capacity of experimenters.
Description
Technical Field
The invention relates to the technical field of medical experimental equipment, and particularly discloses a nude mouse subcutaneous tumor forming device.
Background
The nude mouse subcutaneous tumor formation experiment is an experiment for constructing an animal tumor model and testing the effect of a medicament on tumors. The specific operation steps are as follows: injecting cancer cells subcutaneously in a nude mouse, growing solid tumor (non-functional cell mass formed by the cancer cells) near the injection site when the cancer cells are divided and grow to a certain degree, and periodically measuring the volume of the solid tumor to judge the effect of the drug (the drug is generally injected from the tail vein of the nude mouse and reaches the tumor site of the nude mouse through blood circulation) on the tumor. However, the growth of tumors is affected by a variety of factors, and the resulting solid tumors are irregular in external shape, resulting in an inefficient measurement of the volume of the solid tumor. The solution in the related art is as follows: preparing a large number of nude mouse tumor models, selecting the nude mouse with relatively regular solid tumor shape for measurement, and discarding the nude mouse with irregular solid tumor shape. However, this results in a large waste of experimental resources and also results in repeated labor by the experimenter. Therefore, it is urgently needed to develop a device for limiting tumor growth, improve the success rate of constructing a nude mouse subcutaneous tumor model, and obtain a nude mouse model with a relatively regular solid tumor shape.
Disclosure of Invention
The invention aims to provide a nude mouse subcutaneous tumor forming device to solve the problem of great waste of experimental resources caused by abandoning of irregular tumor shapes in the related technology.
In order to achieve the purpose, the basic scheme of the invention is as follows: a nude mouse subcutaneous tumor forming device comprises a positioning frame, a shape limiting unit, an elastic band I and an elastic band II, wherein the positioning frame comprises an upper frame body and a lower frame body, and the upper frame body is detachably connected with the lower frame body; the shape limiting unit comprises two hemispherical cover bodies which can be spliced to form a spherical cavity with an opening at the bottom, each hemispherical cover body is provided with a fixing piece, and the fixing pieces are clamped between the upper frame body and the lower frame body; elastic band I and elastic band II are fixed connection respectively in the both sides of framework down, and the one end fixedly connected with nylon velvet area I of framework under the elastic band I kept away from, and the one end fixedly connected with nylon hook area of framework under the elastic band II kept away from.
The working principle and the beneficial effects of the basic scheme are as follows: through nylon pile belt I on elastic webbing I and the nylon hook area on the elastic webbing II with locating frame fixed mounting on the nude mouse body, and the tumour cell inoculation position on the nude mouse body is in the locating frame, the spherical cavity of two hemisphere cover body amalgamations this moment is located inoculation position department, so that after the inoculation position begins the growth tumour, the tumour can get into in the spherical cavity, thereby inject the shape of tumour growth, make the tumour shape relatively regular, avoid the tumour shape irregular and abandon a large amount of wastes that lead to experimental resources, avoid the massive repetitive labor of experimenter simultaneously, reduce experimenter's the amount of labour.
Because the unit of injecing among this basic scheme is through locating frame fixed mounting, and go up the framework and can dismantle with lower framework and be connected, consequently, the unit of injecing can be changed as required, and at tumour growth in-process, the tumour grows gradually, and the hemisphere cover body of renewal so that provide the space for tumour growth.
In addition, the inoculation position of the tumor cells usually selects the position with abundant subcutaneous blood vessels, such as the axilla of forelimb, the inguinal position of hind limb and the like, and the tumor is easy to fester due to friction generated during the activity of the nude mouse, so that the positioning frame and the shape limiting unit in the basic scheme can protect the tumor and avoid the fester of the tumor due to friction.
Optionally, the lower frame body is provided with a plurality of fixing columns along the circumferential direction of the lower frame body, the top ends of the fixing columns are provided with threaded portions, and the threaded portions are in threaded connection with caps; the upper frame body is provided with a plurality of through holes for the fixing columns to pass through, and the diameter of the cap is larger than that of the through holes; the fixing piece is provided with a plurality of mounting holes for the fixing columns to penetrate through.
Through the screw-thread fit of cap and the screw thread portion on fixed capital end, realize going up the framework and being connected with dismantling of framework down to make things convenient for the experimenter to change the limited unit of new as required, easy operation. In addition, in the scheme, the fixing sheet of the shape limiting unit can be directly pressed on the lower frame body, the upper frame body does not need to be used, and the size of the device is reduced on the whole.
Optionally, the lower frame body is provided with a plurality of fixing columns along the circumferential direction of the lower frame body, the top ends of the fixing columns are provided with limiting columns, the upper frame body is provided with through holes for the limiting columns to pass through, an arc-shaped groove is arranged beside each through hole and communicated with the through holes, the width of each arc-shaped groove is smaller than the diameter of each limiting column, and the arc-shaped grooves are used for the fixing columns to move; the bottom surface of the upper frame body is fixedly connected with an elastic gasket, the fixing piece is provided with a mounting hole for the fixing column to pass through, and the axial length of the fixing column is smaller than the sum of the thicknesses of the upper frame body, the fixing piece and the elastic gasket and larger than the sum of the thicknesses of the upper frame body and the fixing piece.
In the scheme, after the fixing sheet of the shape limiting unit is clamped between the upper frame body and the lower frame body, pressing force is applied to the upper frame body, the elastic gasket is compressed, then the upper frame body is twisted, so that the fixing column moves in the arc-shaped groove, the elastic gasket fixedly connected to the bottom surface of the upper frame body has elasticity, and the diameter of the limiting column is larger than the width of the arc-shaped groove.
Optionally, the hemispherical cover body is provided with an air hole.
The air holes on the hemispherical cover body are communicated with the spherical cavity and the outside, so that the air in the spherical cavity is ensured to keep circulating.
Optionally, one end of the elastic band I, which is close to the positioning frame, is fixedly connected with an elastic supporting band, and one end of the elastic supporting band, which is far away from the elastic band I, is fixedly connected with a nylon velvet belt II.
The nylon velvet ribbon II on the elastic support belt is bonded with the nylon hook belt on the elastic belt II, a wearing ring is formed between the elastic support belt and the elastic belt I, when the tumor inoculation part is the axilla of the forelimb, the other forelimb of the nude mouse is positioned in the wearing ring, and when the tumor inoculation part is the groin of the hind limb, the other hind limb of the nude mouse is positioned in the wearing ring, so that the stability of the positioning frame on the nude mouse body is further improved.
Optionally, the hemispherical cover body is made of a transparent material.
The experimental person can directly observe the growth condition of the tumor in the spherical cavity through the hemispherical cover body conveniently.
Optionally, the upper frame body and the lower frame body are both made of plastics.
The plastic has light weight and low cost.
Optionally, the resilient gasket is a rubber gasket.
The rubber gasket has good elasticity and is easy to obtain.
Optionally, the upper frame body and the lower frame body are both circular rings.
When the upper frame body and the lower frame body are both circular rings, sharp edges and corners do not exist, and the nude mouse is prevented from being scratched.
Optionally, the fixing column is integrally formed with the lower frame.
When the fixing column and the lower frame body are integrally formed, the fixing column is not easy to separate from the lower frame body.
Drawings
FIG. 1 is a schematic structural diagram of a subcutaneous tumor formation device for nude mice according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a positioning frame according to an embodiment;
FIG. 3 is a longitudinal sectional view of a subcutaneous tumorigenic device of a nude mouse, according to an embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a subcutaneous tumor formation device for nude mice according to a second embodiment of the present invention;
FIG. 5 is a schematic structural diagram of a positioning frame according to a second embodiment;
FIG. 6 is a longitudinal sectional view of a subcutaneous tumorigenic device in a nude mouse according to the second embodiment.
Detailed Description
The following is further detailed by way of specific embodiments:
reference numerals in the drawings of the specification include: the elastic band I1, the elastic band II 2, the upper frame body 3, the lower frame body 4, the fixing column 5, the cap 6, the through hole 7, the hemispherical cover body 8, the curved surface section 810, the vertical section 820, the air hole 9, the fixing piece 10, the nylon velvet belt I11, the nylon hook belt 12, the elastic support belt 13, the nylon velvet belt II 14, the limiting column 15, the arc-shaped groove 16 and the elastic gasket 17.
Example one
This embodiment is substantially as shown in fig. 1, 2 and 3: a nude mouse subcutaneous tumor forming device comprises a positioning frame, a shape limiting unit, an elastic band I1 and an elastic band II 2. The positioning frame comprises an upper frame body 3 and a lower frame body 4, and in the embodiment, the upper frame body 3 and the lower frame body 4 are both made of plastics. The upper frame body 3 and the lower frame body 4 are both circular rings, so that sharp edges and corners are avoided, and a nude mouse is prevented from being scratched. The upper frame body 3 is detachably connected to the lower frame body 4, specifically, the lower frame body 4 is integrally formed with a plurality of fixing columns 5 along the circumferential direction thereof, and in this embodiment, the number of the fixing columns 5 is six. The top end of the fixed column 5 is provided with a threaded part, and the threaded part is in threaded connection with a cap 6; go up framework 3 and seted up a plurality of through-holes 7 that supply fixed column 5 to pass, the diameter of cap 6 is greater than the diameter of through-hole 7, and in this embodiment, the quantity of through-hole 7 is six.
The shape limiting unit comprises two hemispherical covers 8 which can be spliced to form a spherical cavity with an opening at the bottom, and each hemispherical cover 8 comprises a curved section 810 and a vertical section 820. The bleeder vent 9 has been seted up on the hemisphere cover body 8, and hemisphere cover body 8 adopts transparent material to make, and in this embodiment, hemisphere cover body 8 adopts transparent plastic to make, makes things convenient for the experimenter to be can the direct observation tumour growth condition. Each hemispherical cover body 8 is fixedly connected with a fixing piece 10, the fixing piece 10 is clamped between the upper frame body 3 and the lower frame body 4, a plurality of mounting holes for the fixing columns 5 to pass through are formed in the fixing piece 10, in the embodiment, the number of the mounting holes is six, and the fixing piece 10 can be in a semicircular ring shape or a thin plate in any shape such as a rectangle.
Elastic band I1 and elastic band II 2 are fixed connection respectively in the both sides of framework 4 down, and elastic band I1 keeps away from one end fixedly connected with nylon velvet belt I11 of framework 4 down, and elastic band II 2 keeps away from the one end fixedly connected with nylon hook area 12 of framework 4 down, and elastic band I1 is close to the one end fixedly connected with elasticity subband 13 of locating frame, and elastic band I1's one end fixedly connected with nylon velvet belt II 14 is kept away from to elasticity subband 13.
The specific implementation process is as follows: when the experimenter selects the left forelimb armpit of the nude mouse as the tumor cell inoculation part, the lower frame body 4 is placed on the nude mouse after the tumor cell inoculation, so that the tumor inoculation part is enclosed in the range of the lower frame body 4. The elastic belt I1 and the elastic belt II 2 are wound around the body of the nude mouse (the elastic belt I1 and the elastic belt II 2 can be wound around the body of the nude mouse for one circle or more, so that the stability of the lower frame body 4 mounted on the nude mouse is improved), and the lower frame body 4 is fixed on the body of the nude mouse by bonding the nylon velvet belt I11 on the elastic belt I1 and the nylon hook belt 12 on the elastic belt II 2. And then the elastic supporting belt 13 is wound around the right front limb of the nude mouse, so that the elastic supporting belt 13 is positioned between the right front limb and the head of the nude mouse, the nylon velvet belt II 14 on the elastic supporting belt 13 is bonded with the nylon hook belt 12 on the elastic belt II 2, and at the moment, the elastic belt I1 is positioned under the armpit of the right front limb, so that the stability of the installation of the lower frame body 4 on the nude mouse body is further improved, and the lower frame body 4 is not easy to displace.
Then, the two hemispherical covers 8 are respectively installed on the lower frame 4, specifically, the fixing piece 10 is placed on the lower frame 4, the installation hole on the fixing piece 10 is used for the fixing column 5 to pass through, the upper frame 3 is placed on the fixing piece 10, the through hole 7 on the upper frame 3 is used for the fixing column 5 to pass through, finally, the cap 6 is screwed on the threaded part at the top end of the fixing column 5, the cap 6 is made to press the upper frame 3, and the fixing piece 10 is clamped between the upper frame 3 and the lower frame 4. After the installation, two hemisphere cover 8 amalgamation bottoms have the spherical cavity of open-ended, and the tumour inoculation position is located the below of opening part, and the tumour begins to grow the back, can follow the opening part and grow to spherical cavity in, the shape of restriction tumour for the tumour is at the growth process, and the shape is comparatively regular, is partial to spherically.
In the process of tumor growth, an experimenter can observe the growth condition of the tumor in the spherical cavity through the transparent hemispherical cover body 8 at any time. When the tumour is about to be full of spherical cavity, the experimenter need change new hemisphere cover body 8, specifically, take off cap 6 from fixed column 5 rotation, take off last framework 3 again, go up framework 3 and break away from fixed column 5, can take off stationary blade 10 from fixed column 5 afterwards, change new hemisphere cover body 8, form new, the spherical cavity that the volume is bigger, provide sufficient space for tumour growth.
In this embodiment, the shape that the limited unit can inject tumour to grow for the tumour shape is relatively regular, avoids tumour shape irregularity and abandons a large amount of wastes that lead to experimental resources, avoids a large amount of repeated labours of experimenter simultaneously, reduces experimenter's the amount of labour. In addition, the limiting unit can isolate and protect the tumor, and the tumor is prevented from being ulcerated due to friction.
Example two
The present embodiment is different from the first embodiment in that: the positioning frame has different structures, as shown in fig. 4, 5 and 6, the lower frame body 4 is integrally formed with a plurality of fixing posts 5 along the circumferential direction thereof, in this embodiment, the number of the fixing posts 5 is six. The top end of the fixed column 5 is integrally formed with a limiting column 15, the upper frame body 3 is provided with through holes 7 for the limiting column 15 to pass through, an arc-shaped groove 16 is formed beside each through hole 7, the arc-shaped grooves 16 are communicated with the through holes 7, the width of each arc-shaped groove 16 is smaller than the diameter of the limiting column 15, and the arc-shaped grooves 16 are used for the fixed column 5 to move.
Go up the bottom surface fixedly connected with resilient pad 17 of framework 3, in this embodiment, resilient pad 17 chooses for use the rubber gasket, and resilient pad 17 can not shelter from arc 16 and through-hole 7. The fixing piece 10 is provided with mounting holes for the fixing posts 5 to pass through, and in the embodiment, the number of the mounting holes is four. The axial length of the fixing post 5 is smaller than the sum of the thicknesses of the upper frame 3, the fixing piece 10 and the elastic pad 17, and is larger than the sum of the thicknesses of the upper frame 3 and the fixing piece 10.
In this embodiment, after the lower frame 4 is placed on a nude mouse and fixed, the fixing plate 10 is placed on the lower frame 4, the fixing post 5 passes through the mounting hole of the fixing plate 10, the upper frame 3 is placed on the fixing plate 10, and the through hole 7 of the upper frame 3 passes through the limiting post 15. Then, the upper frame body 3 is pressed, the elastic gasket 17 on the bottom surface of the lower frame body 4 is compressed, the limiting column 15 is completely exposed out of the through hole 7 of the upper frame body 3 at the moment, a gap is formed between the bottom surface of the limiting column 15 and the upper surface of the upper frame body 3, the upper frame body 3 is rotated anticlockwise, the fixing column 5 is transferred into the arc-shaped groove 16, finally the upper frame body 3 is released, the upper frame body 3 moves upwards under the action of the elastic gasket 17, the upper frame body 3 is abutted against the limiting column 15, and the fixing sheet 10 is clamped between the upper frame body 3 and the lower frame body 4.
When the hemispherical cover body 8 needs to be detached, the upper frame body 3 is rotated clockwise after the upper frame body 3 is pressed, so that the limiting columns 15 are aligned with the through holes 7 of the upper frame body 3, the upper frame body 3 can be taken down, and then the fixing piece 10 is taken down. Compared with the scheme of the first embodiment, the method does not need to rotate the caps one by one, and is simpler and quicker to operate.
The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the present invention.
Claims (10)
1. A nude mouse subcutaneous tumorigenic device is characterized in that: the positioning frame comprises an upper frame body and a lower frame body, and the upper frame body is detachably connected with the lower frame body; the shape limiting unit comprises two hemispherical cover bodies which can be spliced to form a spherical cavity with an opening at the bottom, each hemispherical cover body is provided with a fixing piece, and the fixing pieces are clamped between the upper frame body and the lower frame body; elastic band I and elastic band II are fixed connection respectively in the both sides of framework down, and the one end fixedly connected with nylon velvet area I of framework under the elastic band I kept away from, and the one end fixedly connected with nylon hook area of framework under the elastic band II kept away from.
2. The nude mouse subcutaneous tumorigenic device of claim 1, wherein: the lower frame body is provided with a plurality of fixing columns along the circumferential direction, the top ends of the fixing columns are provided with threaded parts, and the threaded parts are in threaded connection with caps; the upper frame body is provided with a plurality of through holes for the fixing columns to pass through, and the diameter of the cap is larger than that of the through holes; the fixing piece is provided with a plurality of mounting holes for the fixing columns to penetrate through.
3. The nude mouse subcutaneous tumorigenic device of claim 1, wherein: the lower frame body is provided with a plurality of fixing columns along the circumferential direction, the top ends of the fixing columns are provided with limiting columns, the upper frame body is provided with through holes for the limiting columns to pass through, an arc-shaped groove is arranged beside each through hole and communicated with the through holes, the width of each arc-shaped groove is smaller than the diameter of each limiting column, and the arc-shaped grooves are used for the fixing columns to move; the bottom surface of the upper frame body is fixedly connected with an elastic gasket, the fixing piece is provided with a mounting hole for the fixing column to pass through, and the axial length of the fixing column is smaller than the sum of the thicknesses of the upper frame body, the fixing piece and the elastic gasket and larger than the sum of the thicknesses of the upper frame body and the fixing piece.
4. The nude mouse subcutaneous tumorigenic device of any one of claims 1-3, wherein: the hemispherical cover body is provided with air holes.
5. The nude mouse subcutaneous tumorigenic device of claim 4, wherein: one end fixedly connected with elasticity braced belt that elastic webbing I is close to the locating frame, one end fixedly connected with nylon velvet ribbon II that elastic webbing I kept away from elastic webbing I is braced belt.
6. The nude mouse subcutaneous tumorigenic device of claim 4, wherein: the hemisphere cover body is made of transparent materials.
7. The nude mouse subcutaneous tumorigenic device of claim 1, wherein: the upper frame body and the lower frame body are both made of plastics.
8. The nude mouse subcutaneous tumorigenic device of claim 3, wherein: the elastic gasket is a rubber gasket.
9. The nude mouse subcutaneous tumorigenic device of claim 1, wherein: the upper frame body and the lower frame body are both circular rings.
10. The nude mouse subcutaneous tumorigenic device of claim 1, wherein: the fixing column and the lower frame body are integrally formed.
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| CN201911100778.9A CN110680555B (en) | 2019-11-12 | 2019-11-12 | Nude mouse subcutaneous tumor forming device |
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