CN110665104A - Multichannel stimulation wake-up promoting system - Google Patents
Multichannel stimulation wake-up promoting system Download PDFInfo
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- CN110665104A CN110665104A CN201910922092.1A CN201910922092A CN110665104A CN 110665104 A CN110665104 A CN 110665104A CN 201910922092 A CN201910922092 A CN 201910922092A CN 110665104 A CN110665104 A CN 110665104A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0083—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus especially for waking up
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Abstract
The invention provides a multichannel stimulation wake-up promoting system which comprises a CPU control unit, a carrier, a trigeminal nerve electrical stimulation unit, an auditory stimulation unit and a visual stimulation unit, wherein the carrier is used for carrying out stimulation treatment on the trigeminal nerve; the carrier is arranged on the head of a patient in a wearable manner, and an electric stimulation area and a visual stimulation area are arranged on the carrier; the trigeminal nerve electrical stimulation unit comprises a combined electrode, the combined electrode comprises a first electrode and a second electrode, and the CPU control unit controls the first electrode and the second electrode to send out electrical stimulation signals; the auditory stimulation unit comprises two in-ear players, and the CPU control unit controls the two in-ear players to send out sound stimulation signals; the visual stimulation unit comprises a plurality of flashing wake-up prompting lamps, the flashing wake-up prompting lamps are arranged on the carrier, and the CPU control unit controls the flashing wake-up prompting lamps to generate light stimulation signals. The invention can integrate three different awakening means of trigeminal nerve electrical stimulation, auditory stimulation and visual stimulation, thereby promoting the early awakening and recovery functions of the unconscious patient.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to a multichannel stimulation wake-up promoting system.
Background
At present, the conventional treatment for coma after brain injury mainly comprises neurotrophic drugs, hyperbaric oxygen, comprehensive sensory stimulation, rehabilitation training and the like. Clinically, comatose users are often awakened by comprehensive sensory stimuli, including visual, auditory, tactile, proprioceptive, and the like, such as encouraging families to awaken with familiar and familiarity sounds, touch of limbs, and other familial call patterns.
The trigeminal nerve is connected with the brain stem trigeminal nucleus, plays an important role in pain sensation and consciousness maintenance, and can be said to be ' moving the whole body by pulling one ' in one stroke '. Trigeminal nerve electrical stimulation has the effect of waking up a comatose user after brain injury, the mechanism is that trigeminal nerve electrical stimulation activates a brain stem reticular epithelium exciting system, and afferent fibers of the system are widely projected to a cerebral cortex, so that the cerebral cortex keeps consciousness and clear-headed, and the system has good perception capability on afferent information.
Auditory stimulation is mainly to redistribute brain functions by utilizing brain plasticity, after sound stimulation signals are received by ears, the sound stimulation signals can enter central nerves as soon as possible through auditory sense, enter cerebral cortex from thalamus, and then improve excitability of cerebral cortex, help patients to reestablish sensory nerves and motor nerves on the basis of keeping complete cerebral area, and prompt patients to wake up as soon as possible.
The visual stimulation can increase the local blood flow of the brain to achieve the aim of arousing while inducing the endogenous vibration characteristic of the brain through the light driving effect. In addition, the more the visual afferent impulses enter the brain stem network structure through the side branch, the stronger the ascending awakening effect on the cerebral cortex is, the better the excitation state of the cortex is, and the more perfect the sensation generated by uploading to a specific projection system is. The non-specific up-stream activation system is activated by a specific projection system of visual stimuli to maintain a general waking response.
Based on the above, the application provides a multichannel stimulation wake-up promoting system based on trigeminal nerve electrical stimulation, auditory stimulation and visual stimulation.
Disclosure of Invention
Aiming at the defects of single wakening promotion mode and dispersion in the prior art, the invention provides a multi-channel stimulation wakening promotion system which can integrate three different wakening promotion means of trigeminal nerve electrical stimulation, auditory stimulation and visual stimulation, thereby promoting the early wakening and recovery functions of a coma patient.
In order to achieve the aim, the invention provides a multichannel stimulation arousal system which is used for arousing coma after brain injury of a patient and comprises a CPU control unit, a carrier, a trigeminal nerve electrical stimulation unit, an auditory stimulation unit and a visual stimulation unit; the carrier is arranged on the head of the patient in a wearable manner, and is provided with an electric stimulation area inosculated with the trigeminal nerve of the face of the patient and a visual stimulation area inosculated with the eyes of the patient; the trigeminal nerve electrical stimulation unit comprises a combined electrode acting on an electrical stimulation area, the combined electrode comprises a first electrode and a second electrode, the first electrode and the second electrode are electrically connected, the first electrode and the second electrode are both positioned on the inner side surface of the carrier and are in direct contact with the skin of a patient, and the CPU control unit controls the first electrode and the second electrode to send out electrical stimulation signals according to a set electrical stimulation program; the auditory stimulation unit comprises two in-ear players acting on the ears of the patient, and the CPU control unit controls the two in-ear players to send out sound stimulation signals according to a set auditory stimulation program; the vision stimulation unit comprises a plurality of flashing wake-up prompting lamps acting on the eyes of a patient, the flashing wake-up prompting lamps are arranged on the carrier, and the CPU control unit controls the flashing wake-up prompting lamps to generate light stimulation signals according to a set vision wake-up prompting program.
In the technical scheme of the invention, the CPU control unit can simultaneously control the trigeminal nerve electrical stimulation unit, the auditory stimulation unit and the visual stimulation unit so as to realize the cooperative work of three different wake-up promoting modes and further obtain a better wake-up promoting effect.
According to another embodiment of the present invention, the first electrode has a plurality of first electrode pads, the second electrode has a plurality of second electrode pads, the number of the first electrode pads is the same as that of the second electrode pads, the first electrode pads and the second electrode pads are in one-to-one correspondence, and the first electrode pads and the second electrode pads which are in correspondence with each other are connected by wires.
According to another specific embodiment of the present invention, the carrier is further provided with an attachment structure for mounting the combined electrode, the attachment structure is provided with a plurality of mounting grooves with different positions, and the first electrode and the second electrode are detachably disposed in the mounting grooves.
In the invention, the carrier is preferably a mask with a double-layer structure, and the position of the attachment structure relative to the carrier can be locally adjusted, for example, the attachment structure can be adhered to the carrier, so that the accurate position of the combined electrode can be better adjusted, and different patients can be better adapted.
Specifically, first electrode, second electrode can for example be put into the mounting groove through the mode of pegging graft in, for example the cell wall of mounting groove is flexible colloidal silica, and the electrode can carry out the dismouting under the effect of external force to carry out the adjustment of position.
According to another embodiment of the invention, the attachment structure is provided with a connection slot for a conductor to pass through.
According to another embodiment of the invention, the auditory arousal program in the auditory stimulation unit has a stimulation intensity of 65-75 dB SPL, and the stimulation pattern comprises:
high-frequency mode: f is more than or equal to 1000HZ and less than or equal to 4000 HZ;
low-frequency mode: f is more than or equal to 350HZ and less than or equal to 1000 HZ; wherein F is the stimulation frequency; and
a mono mode.
Specifically, the stimulation duration of the auditory awaking program of the auditory stimulation unit is 250ms, and the interval between two times of stimulation is 300 ms.
According to another embodiment of the invention, a plurality of flashing wake-up lamps are distributed on the eyes of the patient in a surrounding manner, for example, six flashing wake-up lamps are respectively arranged on the left eye and the right eye, wherein the colors of the six flashing wake-up lamps can be the same or different.
According to another embodiment of the present invention, the visual wake-up program in the visual stimulation unit includes a single-eye wake-up program and a double-eye wake-up program, wherein the visual wake-up program can control the flashing light wake-up lamps to be simultaneously turned on, and can also control any one of the flashing light wake-up lamps to flash.
According to another embodiment of the present invention, the light intensity in the visual awaking program in the visual stimulation unit is 10-100 Nit/f, and the stimulation frequency band comprises:
high frequency band: 4f1 +/-3 Hz;
and (3) intermediate frequency band: 2f1 +/-3 Hz;
low frequency band: f1 +/-3 Hz;
where f1 is the spontaneous alpha frequency of the brain, and can be obtained from the brain waves of the patient.
Specifically, the stimulation duration of the visual awaking program in the visual stimulation unit is 100ms, and the stimulation interval is 200 ms.
The invention has the following beneficial effects:
the invention can integrate three different awakening means of trigeminal nerve electrical stimulation, auditory stimulation and visual stimulation, thereby promoting the early awakening and recovery functions of the unconscious patient, improving the success rate of resuscitation and reducing the fatality rate
The present invention will be described in further detail with reference to the accompanying drawings.
Drawings
FIG. 1 is a schematic diagram of a multi-channel stimulatory wake system of the present invention;
FIG. 2 is a schematic diagram of the use of the multi-channel stimulatory wake system of the present invention;
fig. 3 is a state diagram of the use of the visual stimulation unit in the multi-channel stimulation arousal system of the invention.
Detailed Description
Example 1
As shown in fig. 1-3, a multi-channel stimulation wake-up promoting system for coma wake-up after brain injury of a patient comprises a CPU control unit 1, a carrier 2, a trigeminal electrical stimulation unit 3, an auditory stimulation unit 4 and a visual stimulation unit 5, wherein the CPU control unit 1 cooperatively controls the trigeminal electrical stimulation unit 3, the auditory stimulation unit 4 and the visual stimulation unit 5.
The carrier 2 in the present embodiment has a mask structure, and in other examples of the present invention, a structure such as a spectacle-shaped structure may be used, in which an electrical stimulation region O1 that coincides with the trigeminal nerve of the face of the patient and a visual stimulation region O2 that coincides with the eyes of the patient are provided on the carrier 2.
The trigeminal electrical stimulation unit 3 comprises a combined electrode 3a and an attachment structure 3b which are positioned in an electrical stimulation area O1, wherein the combined electrode 3a comprises a first electrode 31 and a second electrode 32 which are both positioned on the inner side surface of the carrier 2, so that the combined electrode can be directly contacted with the skin of a patient for electrical stimulation.
A plurality of mounting grooves 33 with different positions are arranged on the attachment structure 3b, and the first electrode 31 and the second electrode 32 are arranged in the mounting grooves 33; the first electrode 31 and the second electrode 32 can be inserted into the mounting groove in an inserting manner, for example, the wall of the mounting groove 33 is a flexible silica gel body, and the electrodes can be disassembled and assembled under the action of the external force, so that the position can be adjusted conveniently.
Referring to fig. 2, in the present embodiment, the first electrode 31 has two first electrode pieces, the second electrode has two second electrode pieces, the first electrode pieces correspond to the second electrode pieces one by one, the first electrode pieces and the second electrode pieces corresponding to each other are connected by a wire, and a connection groove (not shown) for the wire to pass through is provided in the center of the attachment structure 3 b.
The CPU control unit 1 controls the first electrode 31 and the second electrode 32 to send out electrical stimulation signals according to a set electrical stimulation program so as to complete the electrical stimulation process of a patient.
The auditory stimulation unit 4 includes a left ear player 41 and a right ear player 42 acting on the ear of the patient, and the CPU control unit 1 is provided with a plurality of auditory arousal programs, for example, four binaural stimulation modes, each of which uses SPL with an intensity of 70dB, and the audio type is "tic" pure tone, and the four binaural stimulation modes are:
mode A: 350Hz, 700Hz, 1400Hz, 2800 Hz;
and (3) mode B: 400Hz, 800Hz, 1600Hz, 3200 Hz;
and mode C: 450Hz, 900Hz, 1800Hz, 3600 Hz;
mode D: 500Hz, 1000Hz, 2000Hz, 4000 Hz;
the sound giving time of the auditory awaking program is 250ms, and the interval between two times of stimulation is 300 ms.
The CPU control unit 1 controls the left ear player 41 and the right ear player 42 to send out sound stimulation signals according to the set auditory awaking program so as to complete the auditory stimulation process of the patient.
The visual stimulation unit 5 comprises twelve flashing wake-up promoting lamps 51, the twelve flashing wake-up promoting lamps 51 are divided into two groups and are respectively arranged at positions corresponding to the left eye and the right eye of a patient on the carrier 2, wherein the six flashing wake-up promoting lamps 51 of the right eye are distributed as shown in fig. 3, the CPU control unit 1 controls the six flashing wake-up promoting lamps 51 to generate light stimulation signals according to a set visual wake-up program, the visual wake-up program comprises a single-eye wake-up promoting program and a double-eye wake-up promoting program, and the CPU control unit 1 can simultaneously control the six flashing wake-up promoting lamps 51 to be simultaneously lightened and also can control any one of the flashing wake-up promoting lamps 51 to flicker.
Wherein the light in the visual awaking program in the visual stimulation unit is 10-100 Nit/f, and the stimulation frequency band comprises:
high frequency band: 4f1 +/-3 Hz;
and (3) intermediate frequency band: 2f1 +/-3 Hz;
low frequency band: f1 +/-3 Hz;
where f1 is the spontaneous alpha frequency of the brain, and can be obtained from the brain waves of the patient.
Specifically, the stimulation duration of the visual awaking program is 100ms, and the stimulation interval is 200 ms.
In this embodiment, the six flashing wake-up promoting lamps have different colors, and the flashing stimulation process is performed by using lights of six colors, namely red, green, blue, purple, yellow and white.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to limit the scope of the invention. It will be appreciated by those skilled in the art that changes may be made without departing from the scope of the invention, and it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.
Claims (10)
1. A multi-channel stimulatory waking system for coma waking after brain injury in a patient, comprising:
a CPU control unit;
the carrier is arranged on the head of the patient in a wearable manner, and is provided with an electric stimulation area inosculated with the trigeminal nerve of the face of the patient and a visual stimulation area inosculated with the eyes of the patient;
the trigeminal electrical stimulation unit comprises a combined electrode acting on an electrical stimulation area, the combined electrode comprises a first electrode and a second electrode, the first electrode and the second electrode are electrically connected, both the first electrode and the second electrode are positioned on the inner side surface of the carrier and are in direct contact with the skin of a patient, and the CPU control unit controls the first electrode and the second electrode to send out electrical stimulation signals according to a set electrical stimulation program;
the auditory stimulation unit comprises two in-ear players acting on the ears of a patient, and the CPU control unit controls the two in-ear players to send out sound stimulation signals according to a set auditory prompting program;
visual stimulation unit, including acting on a plurality of flashing of patient's eye and promoting the wakening lamp, it is a plurality of flash is promoted the wakening lamp and is established on the carrier, CPU control unit control is a plurality of flash is promoted the wakening lamp and is produced light stimulus signal according to setting for vision and promoting the form of awaking.
2. The multi-channel stimulation wake-up promoting system according to claim 1, wherein the first electrode has a plurality of first electrode pads, the second electrode has a plurality of second electrode pads, the number of the first electrode pads is the same as that of the second electrode pads, the first electrode pads and the second electrode pads are in one-to-one correspondence, and the first electrode pads and the second electrode pads which correspond to each other are connected through leads.
3. The multi-channel stimulation wake-up promoting system according to claim 2, wherein the carrier is further provided with an attachment structure for mounting the combined electrode, the attachment structure is provided with a plurality of mounting grooves with different positions, and the first electrode and the second electrode are detachably arranged in the mounting grooves.
4. A multi-channel stimulatory wake system according to claim 3, wherein the attachment structure is provided with attachment slots for the passage of the conductors.
5. The multi-channel stimulation wake-up system as claimed in claim 1 wherein the stimulation intensity of the auditory wake-up program in the auditory stimulation unit is 65-75 dB SPL with stimulation patterns comprising:
high-frequency mode: f is more than or equal to 1000HZ and less than or equal to 4000 HZ;
low-frequency mode: f is more than or equal to 350HZ and less than or equal to 1000 HZ; wherein F is the stimulation frequency; and
a mono mode.
6. The multi-channel stimulation wake-up system as claimed in claim 5, characterized in that the auditory wake-up program of the auditory stimulation unit has a sound delivery duration of 250ms and a stimulation interval of 300 ms.
7. The multi-channel arousal stimulation system of claim 1 wherein a plurality of the flashing arousal lights are distributed around the eyes of the patient.
8. The multi-channel stimulation wake-up system of claim 1 wherein the visual wake-up program in the visual stimulation unit comprises a monocular wake-up program and a binocular wake-up program.
9. The multi-channel stimulation wake-up system according to claim 8, characterized in that the light in the visual wake-up program in the visual stimulation unit is 10-100 Nit/f, and the stimulation frequency band comprises:
high frequency band: 4f1 +/-3 Hz;
and (3) intermediate frequency band: 2f1 +/-3 Hz;
low frequency band: f1 +/-3 Hz;
wherein f1 is the spontaneous alpha frequency of the brain.
10. The multi-channel stimulation wake-up system as claimed in claim 9 wherein the visual stimulation modality in the visual stimulation unit has a stimulation duration of 100ms and a stimulation interval of 200 ms.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910922092.1A CN110665104A (en) | 2019-09-26 | 2019-09-26 | Multichannel stimulation wake-up promoting system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910922092.1A CN110665104A (en) | 2019-09-26 | 2019-09-26 | Multichannel stimulation wake-up promoting system |
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| CN110665104A true CN110665104A (en) | 2020-01-10 |
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| CN201910922092.1A Pending CN110665104A (en) | 2019-09-26 | 2019-09-26 | Multichannel stimulation wake-up promoting system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939469A (en) * | 2020-08-05 | 2020-11-17 | 深圳扶林科技发展有限公司 | Multi-mode electroencephalogram stimulation device and finger bending and stretching stimulation rehabilitation device |
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2019
- 2019-09-26 CN CN201910922092.1A patent/CN110665104A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939469A (en) * | 2020-08-05 | 2020-11-17 | 深圳扶林科技发展有限公司 | Multi-mode electroencephalogram stimulation device and finger bending and stretching stimulation rehabilitation device |
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