CN110664981A - Veterinary drug for treating poultry diarrhea and preparation process thereof - Google Patents

Veterinary drug for treating poultry diarrhea and preparation process thereof Download PDF

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CN110664981A
CN110664981A CN201911077587.5A CN201911077587A CN110664981A CN 110664981 A CN110664981 A CN 110664981A CN 201911077587 A CN201911077587 A CN 201911077587A CN 110664981 A CN110664981 A CN 110664981A
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fixedly connected
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powder
corn
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王善波
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    • A—HUMAN NECESSITIES
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    • A61K36/718—Coptis (goldthread)
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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Abstract

The invention discloses a veterinary drug for treating diarrhea of poultry and a preparation process thereof, wherein the veterinary drug comprises an anti-inflammatory layer, a slow-release layer and an antidiarrheal layer which are bonded from outside to inside; the anti-inflammatory layer is prepared from the following raw materials in parts by weight: 10-15 parts of coptis chinensis, 20-35 parts of Chinese pulsatilla root, 9-17 parts of kudzu root, 10-20 parts of honeysuckle, 10-15 parts of cogongrass rhizome, 3-15 parts of fructus forsythiae, 8-19 parts of scutellaria baicalensis and 13-17 parts of houttuynia cordata; the slow release layer is prepared from the following raw materials in parts by weight: 80-90 parts of corn flour, 50-60 parts of soybean meal and 5-10 parts of adhesive; the antidiarrheal layer is prepared from the following raw materials in parts by weight: 3-5 parts of codonopsis pilosula, 5-15 parts of bighead atractylodes rhizome, 17-25 parts of baked ginger, 10-15 parts of Chinese yam, 3-6 parts of astragalus membranaceus, 1-3 parts of angelica sinensis, 5-7 parts of white paeony root, 5-13 parts of corydalis tuber, 5-12 parts of elecampane, 5-8 parts of sanguisorba officinalis, 5-9 parts of halloysite, 9-23 parts of catechu and 10-20 parts of liquorice.

Description

Veterinary drug for treating poultry diarrhea and preparation process thereof
Technical Field
The invention relates to the technical field of poultry and animal medicines, in particular to a veterinary medicine for treating poultry diarrhea and a preparation process thereof.
Background
Diarrhea is one of the common important diseases of livestock and poultry, is various diarrhea diseases caused by infection or mixed infection of bacteria such as escherichia coli, diarrhea bacillus, salmonella, pasteurella, clostridium welchii, treponema, rotavirus and the like and viruses, and particularly occurs and prevails in different degrees throughout the year in closed, intensive, large-scale and industrialized animal breeding, so that certain harm and loss are caused to the animal husbandry.
However, the existing veterinary drug for treating diarrhea of poultry generally does not have good anti-inflammation effect when the poultry is subjected to diarrhea treatment, and the poultry generally has infectious inflammation and swelling and pain when diarrhea occurs; meanwhile, the preparation work of the existing veterinary drug for treating poultry diarrhea is generally inconvenient for cleaning the production equipment after the production equipment is disassembled, so that the residual drug components in the production equipment easily cause drug waste, and the production equipment can be infected simultaneously to influence the next use of the production equipment.
Disclosure of Invention
The invention aims to provide a veterinary drug for treating diarrhea of poultry and a preparation process thereof, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a veterinary drug for treating diarrhea of poultry comprises an anti-inflammatory layer, a sustained-release layer and an antidiarrheal layer bonded from outside to inside;
the anti-inflammatory layer is prepared from the following raw materials in parts by weight: 10-15 parts of coptis chinensis, 20-35 parts of Chinese pulsatilla root, 9-17 parts of kudzu root, 10-20 parts of honeysuckle, 10-15 parts of cogongrass rhizome, 3-15 parts of fructus forsythiae, 8-19 parts of scutellaria baicalensis and 13-17 parts of houttuynia cordata;
the slow release layer is prepared from the following raw materials in parts by weight: 80-90 parts of corn flour, 50-60 parts of soybean meal and 5-10 parts of adhesive;
the antidiarrheal layer is prepared from the following raw materials in parts by weight: 3-5 parts of codonopsis pilosula, 5-15 parts of bighead atractylodes rhizome, 17-25 parts of baked ginger, 10-15 parts of Chinese yam, 3-6 parts of astragalus membranaceus, 1-3 parts of angelica sinensis, 5-7 parts of white paeony root, 5-13 parts of corydalis tuber, 5-12 parts of elecampane, 5-8 parts of sanguisorba officinalis, 5-9 parts of halloysite, 9-23 parts of catechu and 10-20 parts of liquorice.
As a further scheme of the invention: the binder is syrup.
As a further scheme of the invention: a coating film is bonded on the peripheral side wall of the anti-inflammatory layer and used for changing the appearance of the veterinary drug and increasing the stability of the veterinary drug;
the coating film is made of hydroxypropyl methylcellulose.
As a further scheme of the invention: the preparation method of the anti-inflammatory layer comprises the following steps:
s1, cleaning rhizoma Coptidis, radix Pulsatillae, radix Puerariae, flos Lonicerae, rhizoma Imperatae, fructus forsythiae, radix Scutellariae, and herba Houttuyniae, air drying, and cutting into segments of 3-5ccm long;
s2, drying the cut Chinese medicine segments in the S1 at 50-60 ℃ for 15-20min, then crushing in a crusher, and sieving with a 50-80 mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 70-80 ℃ for 15-20min while stirring;
s4, putting the mixed raw material after stirring in the S3 into a pulverizer for pulverization, and sieving the pulverized raw material with a 100-mesh and 130-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 150-mesh and 180-mesh sieve to obtain the anti-inflammatory powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer.
The invention is a further proposal: the preparation method of the sustained-release layer comprises the following steps:
putting the corn kernels into a dryer, and drying for 20-30 minutes to reduce the moisture of the corn kernels to 12-14% to obtain dried corn kernels;
adding 5-10% deionized water into the dried corn grains, stirring, standing for 10-15 min until the epidermis of the corn grains can be torn off by hand, and placing into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 120-;
adding soybean powder and adhesive into corn flour, stirring, and drying to obtain the delayed release layer.
As a further scheme of the invention: the preparation method of the antidiarrheal layer comprises the following steps:
removing impurities from radix Codonopsis, Atractylodis rhizoma, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, rhizoma corydalis, radix aucklandiae, radix Sangusorbae, Halloysitum rubrum, Catechu, and Glycyrrhrizae radix, cleaning, mixing, grinding into powder with stone mill, and sieving with 60 mesh sieve to obtain first mixed powder;
peeling rhizoma Dioscoreae and rhizoma Zingiberis Preparata, cleaning, adding distilled water, grinding into slurry, stirring, mixing, and spray drying to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving with a 40-60-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain the antidiarrheal layer.
A veterinary drug for treating diarrhea of poultry is prepared by bonding an anti-inflammatory layer, a sustained-release layer and an antidiarrheal layer from outside to inside;
the preparation method of the anti-inflammatory layer comprises the following steps:
s1, cleaning and airing 10-15 parts of coptis chinensis, 20-35 parts of Chinese pulsatilla root, 9-17 parts of kudzu vine root, 10-20 parts of honeysuckle, 10-15 parts of cogongrass rhizome, 3-15 parts of weeping forsythia capsule, 8-19 parts of scutellaria baicalensis and 13-17 parts of houttuynia cordata, and cutting into Chinese medicinal segments with the length of 3-5 ccm;
s2, drying the cut Chinese medicine segments in the S1 at 50-60 ℃ for 15-20min, then crushing in a crusher, and sieving with a 50-80 mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 70-80 ℃ for 15-20min while stirring;
s4, putting the mixed raw material after stirring in the S3 into a pulverizer for pulverization, and sieving the pulverized raw material with a 100-mesh and 130-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 150-mesh and 180-mesh sieve to obtain the anti-inflammatory powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain an anti-inflammatory layer;
the preparation method of the sustained-release layer comprises the following steps:
putting the corn kernels into a dryer, and drying for 20-30 minutes to reduce the moisture of the corn kernels to 12-14% to obtain dried corn kernels;
adding 5-10% deionized water into the dried corn grains, stirring, standing for 10-15 min until the epidermis of the corn grains can be torn off by hand, and placing into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 120-;
adding 50-60 parts by weight of soybean meal and 5-10 parts by weight of adhesive into 80-90 parts by weight of corn flour, uniformly stirring, and drying to obtain a slow-release layer;
the preparation method of the antidiarrheal layer comprises the following steps:
removing impurities from 3-5 parts of codonopsis pilosula, 5-15 parts of bighead atractylodes rhizome, 17-25 parts of baked ginger, 3-6 parts of astragalus membranaceus, 1-3 parts of angelica sinensis, 5-7 parts of white paeony root, 5-13 parts of rhizoma corydalis, 5-12 parts of elecampane, 5-8 parts of sanguisorba officinalis, 5-9 parts of halloysite, 9-23 parts of catechu and 10-20 parts of liquorice, cleaning, uniformly mixing, grinding into powder by stone grinding, and sieving by a 60-mesh sieve to obtain first mixed powder;
peeling 10-15 parts by weight of Chinese yam and 17-25 parts by weight of baked ginger, cleaning, adding distilled water, grinding into slurry, stirring and mixing uniformly, and then passing through a spray dryer to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving with a 40-60-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain the antidiarrheal layer.
As a further scheme of the invention: the spray dryer comprises a cylindrical barrel, a feeding assembly and a charging assembly;
the top end face of the cylindrical barrel is provided with a through hole, the lower surface of the top plate of the cylindrical barrel is fixedly connected with a heating plate, the bottom end face of the cylindrical barrel is downwards fixedly connected with at least two supporting plates, the heating plate converts electric energy into heat energy, the structure and the working principle of the heating plate are known, so that repeated description is omitted, and the supporting function of the supporting plates on the cylindrical barrel is realized;
the feeding assembly comprises at least two feeding boxes, the feeding boxes are fixedly connected to the circumferential side wall of the cylindrical barrel, one end of each feeding box is communicated with a feeding pipe, the other end of each feeding box is communicated with a spray head, the spray heads are communicated with the inside of the cylindrical barrel, a filter screen is arranged in each feeding box, the upper end of each filter screen is fixedly connected with a connecting plate, the upper end of each connecting plate penetrates through the feeding boxes and is fixedly connected with an annular plate, the annular plates are detachably connected to the side wall of the cylindrical barrel, slurry of Chinese yams and baked gingers flows into the feeding boxes through the feeding pipes, due to the effect of the filter screens, the blockage of the spray heads caused by the inflow of impurities in the Chinese yams and the baked gingers is prevented, and due to the fact that the annular plates are detachably connected to the side wall of the cylindrical barrel, when the annular plates are taken down, thereby facilitating the cleaning of the filter screen and the feed box;
the discharging assembly comprises a charging box, the charging box is located at the lower end of the cylindrical barrel and detachably connected to the supporting plate, and the charging box is detachably connected to the supporting plate, so that the charging box can be conveniently mounted and dismounted on the supporting plate by workers.
As a further scheme of the invention: the two ends of the connecting plate are fixedly connected with sealing rings, the connecting plate and the filter screen are matched with the feeding box, and the sealing effect of the connecting part of the connecting plate and the feeding box is realized by the sealing rings;
the side wall of the through hole is fixedly connected with a discharging cylinder, the inner side wall of the discharging cylinder is horizontally and fixedly connected with a cooling pipe filled with condensate, the circumferential outer side wall of the cooling pipe is movably connected with scraping rings, and clamping rods are fixedly connected between the scraping rings; the outer side wall of the discharging cylinder is fixedly connected with a spring, one end of the spring is fixedly connected with a T-shaped inserting rod, one end of the T-shaped inserting rod penetrates through the side wall of the discharging cylinder and is inserted into the outer side wall of the scraping ring, when liquid is contacted with the cooling pipe in the discharging cylinder, cooling effect is realized due to the fact that cooling liquid is filled in the cooling pipe, and the yam and baked ginger pulp which are deviated upwards are contacted with the cooling pipe and attached to the outer side wall of the cooling pipe; when the Chinese yam and baked ginger serosity attached to the outer side wall of the cooling tube needs to be cleaned, a worker manually pulls the T-shaped insertion rod, when one end of the T-shaped insertion rod is separated from the scraping ring, the worker manually pushes the scraping ring again to move the scraping ring on the outer side wall of the cooling tube, and when the scraping ring moves on the cooling tube, the Chinese yam and baked ginger serosity attached to the outer side wall of the cooling tube is cleaned;
the outer side wall of the scraping ring is provided with a jack for inserting the T-shaped insertion rod;
the side wall of the annular plate is fixedly connected with a fixed block, the fixed block is fixedly connected to the cylindrical barrel through a fixing bolt, the structure and the working principle of the motor are known, so that detailed description is omitted, the motor works, the stirring plate is driven by the rotating rod, and when the stirring plate rotates in the cylindrical barrel, Chinese yam and ginger liquid medicine sprayed in the cylindrical barrel are uniform; when needs realize clearing up adnexed liquid medicine on the cylindrical barrel inside wall through scraping the flitch and clear up, the position of flitch is scraped in the staff adjustment, makes and scrapes flitch and cylindrical barrel inside wall contact, and motor work realizes scraping the flitch and rotates at cylindrical barrel's inside wall, scrapes the flitch and realizes clearing up adnexed liquid medicine on the cylindrical barrel inside wall when rotating and gets off.
As a further scheme of the invention: the lower end of the charging box is fixedly connected with a sliding plate through a connecting rod, the upper surface of the sliding plate is fixedly connected with a motor, an output shaft of the motor penetrates through the charging box and is fixedly connected with a rotating rod, a connecting rod is fixedly connected onto the rotating rod, one end of the connecting rod is fixedly connected with a stirring plate, the connecting rod is movably connected with a scraping plate matched with the inner side wall of the cylindrical barrel, the structure and the working principle of the motor are known, so that detailed description is omitted, the motor works, the stirring plate is driven through the rotating rod, and when the stirring plate rotates in the cylindrical barrel, Chinese yam and ginger liquid medicine sprayed in the cylindrical barrel is uniform; when the liquid medicine attached to the inner side wall of the cylindrical barrel needs to be cleaned through the scraping plate, a worker adjusts the position of the scraping plate to enable the scraping plate to be in contact with the inner side wall of the cylindrical barrel, the motor works to enable the scraping plate to rotate on the inner side wall of the cylindrical barrel, and the scraping plate can clean the liquid medicine attached to the inner side wall of the cylindrical barrel when rotating;
the side wall of the supporting plate is provided with a sliding chute for sliding connection of the sliding plate, the sliding plate is fixedly connected in the sliding chute through a locking bolt, and the sliding chute and the sliding plate are arranged to facilitate the sliding plate to move on the supporting plate;
the charging box is fixedly connected with a cylindrical block for a motor driving shaft to penetrate through.
As a further scheme of the invention: scrape fixedly connected with horizontal pole on the flitch, fixedly connected with montant between the horizontal pole, fixedly connected with threaded rod on the lateral wall of montant, the lateral wall and the fixedly connected with dead lever of dwang are passed to the one end of threaded rod, are located equal threaded connection has the nut on the threaded rod of dwang both sides, when needs adjustment is scraped the flitch and is in the position of cylindrical barrel, the staff removes the dwang to the below of cylindrical barrel, and the staff manual rotation nut again, when the lateral wall of nut and dwang breaks away from, staff manual removal threaded rod to realize that the adjustment is scraped the position of flitch in cylindrical barrel, when scraping the flitch in the suitable position of cylindrical barrel, staff manual rotation nut, realize will scraping the flitch through the nut and fix in suitable position.
Compared with the prior art, the invention has the beneficial effects that:
firstly, an anti-inflammatory layer is arranged on the outermost layer of the veterinary drug, and comprises coptis chinensis, Chinese pulsatilla root, kudzuvine root, honeysuckle, lalang grass rhizome, weeping forsythia, baical skullcap root and heartleaf houttuynia herb, wherein the coptis chinensis has the effects of clearing heat, drying dampness, purging fire and detoxifying; the honeysuckle can disperse wind-heat and clear away blood toxin, and has obvious effect on various heat diseases, such as fever, eruption, speckle, sore and carbuncle due to heat toxin, sore throat and the like; the scutellaria has the effects of clearing heat, drying dampness, purging fire, detoxifying and stopping bleeding; therefore, when the antidiarrheal effect is carried out on the poultry, the anti-inflammatory effect on the poultry can be better.
Two, through setting up the slow release layer between anti-inflammatory layer and the layer of checking diarrhea, when the whole animal remedy of poultry taking, the outermost anti-inflammatory layer of animal remedy absorbs in the abdominal cavity of poultry, at first carry out anti-inflammatory treatment to the poultry, later the slow release layer of this animal remedy absorbs in the abdominal cavity of poultry, be used for separating anti-inflammatory layer and the layer of checking diarrhea and act on the poultry simultaneously in the poultry abdominal cavity, prevent that anti-inflammatory layer and the layer of checking diarrhea traditional chinese medicine effect of checking diarrhea offset each other, after the slow release layer is absorbed in the poultry, the layer of checking diarrhea absorbs in the abdominal cavity of poultry, thereby reach the effect of checking diarrhea to the poultry.
Thirdly, by arranging the spray dryer, the spray dryer comprises a cylindrical barrel, a feeding assembly and a charging assembly, the feeding assembly comprises at least two feeding boxes, the feeding boxes are fixedly connected on the circumferential side wall of the cylindrical barrel, one ends of the feeding boxes are communicated with a feeding pipe, the other ends of the feeding boxes are communicated with a spray head, the spray head is communicated with the inside of the cylindrical barrel, a filter screen is arranged in the feeding boxes, the upper ends of the filter screen are fixedly connected with a connecting plate, the upper ends of the connecting plate penetrate through the feeding boxes and are fixedly connected with an annular plate, the annular plate is detachably connected on the side wall of the cylindrical barrel, the slurry of the Chinese yam and the baked ginger flows into the feeding boxes through the feeding pipe, due to the effect of the filter screen, the Chinese yam and the impurities in the baked ginger flow into the spray head to cause the blockage of the spray head, and because the annular plate is detachably, the filter screen and the connecting plate can be conveniently taken down in the feeding box, so that the filter screen and the feeding box can be conveniently cleaned.
And the discharging assembly comprises a charging box, the charging box is positioned at the lower end of the cylindrical barrel, and the charging box is detachably connected to the supporting plate, so that the charging box is conveniently mounted and dismounted on the supporting plate by a worker.
The veterinary drug for treating poultry diarrhea and the preparation process thereof carry out anti-inflammatory treatment on the poultry before the poultry is subjected to diarrhea, so that a good diarrhea-stopping effect on the poultry is achieved.
Drawings
FIG. 1 is a schematic view of the interior of a spray dryer used in a process for preparing a veterinary drug for treating diarrhea in poultry;
FIG. 2 is an enlarged view of a portion of FIG. 1 at A;
FIG. 3 is an enlarged view of a portion of FIG. 1 at B;
FIG. 4 is a schematic view showing the connection between a charge case and a cylindrical block in a process for preparing a veterinary drug for treating diarrhea in poultry;
FIG. 5 is a schematic view of an annular plate in a process for preparing a veterinary drug for treating diarrhea in poultry;
FIG. 6 is a schematic view of the interior of the discharge cylinder of the manufacturing process for a veterinary drug for treating diarrhea in poultry;
FIG. 7 is a schematic view of the interior of a scraper ring used in the preparation of veterinary drug for treating diarrhea in poultry;
FIG. 8 is a schematic view showing the connection of the cylindrical barrel, the supporting plate and the discharging cylinder in the preparation process of the veterinary drug for treating diarrhea in poultry;
FIG. 9 is a schematic internal view of a veterinary drug for treating diarrhea in poultry;
in the figure: 1. a cylindrical barrel; 2. a through hole; 3. a feeding box; 4. a feed pipe; 5. a spray head; 6. a support plate; 7. a filter screen; 8. a connecting plate; 9. an annular plate; 10. a cartridge; 11. a phase connecting rod; 12. a seal ring; 13. a fixed block; 14. fixing the bolt; 15. heating plates; 16. a slide plate; 17. a motor; 18. rotating the rod; 19. a connecting rod; 20. a material stirring plate; 21. a scraping plate; 22. a cylindrical block; 23. a cross bar; 24. a vertical rod; 25. a threaded rod; 26. fixing the rod; 27. a nut; 28. a discharge cylinder; 29. a cooling tube; 30. a scraping ring; 31. a clamping and connecting rod; 32. a spring; 33. a T-shaped insertion rod; 34. a jack; 35. a chute; 36. locking the bolt; 37. an anti-inflammatory layer; 38. a sustained release layer; 39. and (5) an antidiarrheal layer.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Please refer to FIGS. 1-9
Example one
A veterinary drug for treating diarrhea of poultry comprises an anti-inflammatory layer 37, a sustained-release layer 38 and an antidiarrheal layer 39 bonded from outside to inside;
the anti-inflammatory layer 37 is prepared from the following raw materials in parts by weight: 10 parts of coptis chinensis, 20 parts of Chinese pulsatilla root, 9 parts of kudzuvine root, 10 parts of honeysuckle, 10 parts of cogongrass rhizome, 3 parts of weeping forsythia, 8 parts of baical skullcap root and 13 parts of heartleaf houttuynia herb;
the sustained-release layer 38 is prepared from the following raw materials in parts by weight: 80 parts of corn flour, 50 parts of soybean flour and 5 parts of adhesive;
the antidiarrheal layer 39 is prepared from the following raw materials in parts by weight: 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 17 parts of baked ginger, 10 parts of Chinese yam, 3 parts of astragalus membranaceus, 1 part of angelica sinensis, 5 parts of white paeony root, 5 parts of corydalis tuber, 5 parts of elecampane, 5 parts of sanguisorba officinalis, 5 parts of halloysite, 9 parts of catechu and 10 parts of liquorice.
The binder is syrup.
The peripheral side wall of the anti-inflammatory layer 37 is adhered with a coating film;
the material of the coating film is hydroxypropyl methylcellulose.
The preparation method of the anti-inflammatory layer 37 comprises the following steps:
s1, cleaning rhizoma Coptidis, radix Pulsatillae, radix Puerariae, flos Lonicerae, rhizoma Imperatae, fructus forsythiae, radix Scutellariae, and herba Houttuyniae, air drying, and cutting into 3ccm long segments;
s2, drying the cut Chinese medicine segments in the S1 at 50 ℃ for 15min, then crushing in a crusher, and sieving with a 50-mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 70 ℃ for 15min while stirring;
s4, putting the stirred mixed raw material in the S3 into a pulverizer to be pulverized, and sieving the pulverized mixed raw material with a 100-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 150-mesh sieve to obtain the antiphlogistic powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer 37.
The preparation method of the sustained-release layer 38 comprises the following steps:
putting the corn kernels into a dryer, and drying for 20 minutes to reduce the moisture of the corn kernels to 12% to obtain dried corn kernels;
adding 5-10% deionized water into the dried corn grains, stirring uniformly, standing for 10 min until the epidermis of the corn grains can be torn off by hand, and placing into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 120 meshes, and stopping crushing to obtain corn flour;
adding soybean powder and adhesive into corn flour, stirring, and drying to obtain delayed release layer 38.
The preparation method of the antidiarrheal layer 39 comprises the following steps:
removing impurities from radix Codonopsis, Atractylodis rhizoma, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, rhizoma corydalis, radix aucklandiae, radix Sangusorbae, Halloysitum rubrum, Catechu, and Glycyrrhrizae radix, cleaning, mixing, grinding into powder with stone mill, and sieving with 60 mesh sieve to obtain first mixed powder;
peeling rhizoma Dioscoreae and rhizoma Zingiberis Preparata, cleaning, adding distilled water, grinding into slurry, stirring, mixing, and spray drying to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving the mixture by a 40-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain antidiarrheal layer 39.
A preparation process of a veterinary drug for treating diarrhea of poultry, the preparation method of an anti-inflammatory layer 37 comprises the following steps:
s1, cleaning and airing 10 parts by weight of coptis chinensis, 20 parts by weight of Chinese pulsatilla root, 9 parts by weight of kudzu root, 10 parts by weight of honeysuckle, 10 parts by weight of cogongrass rhizome, 3 parts by weight of forsythia, 8 parts by weight of scutellaria baicalensis and 13 parts by weight of houttuynia cordata, and cutting into Chinese medicinal segments with the length of 3 ccm;
s2, drying the cut Chinese medicine segments in the S1 at 50 ℃ for 15min, then crushing in a crusher, and sieving with a 50-mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 70 ℃ for 15min while stirring;
s4, putting the stirred mixed raw material in the S3 into a pulverizer to be pulverized, and sieving the pulverized mixed raw material with a 100-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 150-mesh sieve to obtain the antiphlogistic powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer 37.
The preparation method of the sustained-release layer 38 comprises the following steps:
putting the corn kernels into a dryer, and drying for 20 minutes to reduce the moisture of the corn kernels to 12% to obtain dried corn kernels;
adding 5-10% deionized water into the dried corn grains, stirring uniformly, standing for 10 min until the epidermis of the corn grains can be torn off by hand, and placing into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 120 meshes, and stopping crushing to obtain corn flour;
adding 50 parts by weight of soybean meal and 5 parts by weight of adhesive into 80 parts by weight of corn flour, uniformly stirring, and drying to obtain the slow-release layer 38.
The preparation method of the antidiarrheal layer 39 comprises the following steps:
removing impurities from raw materials of 3 parts by weight of radix codonopsitis, 5 parts by weight of rhizoma atractylodis macrocephalae, 17 parts by weight of baked ginger, 10 parts by weight of Chinese yam, 3 parts by weight of radix astragali, 1 part by weight of angelica, 5 parts by weight of radix paeoniae alba, 5 parts by weight of rhizoma corydalis, 5 parts by weight of radix aucklandiae, 5 parts by weight of sanguisorba officinalis, 5 parts by weight of halloysite, 9 parts by weight of catechu and 10 parts by weight of liquorice, cleaning, mixing uniformly, grinding into powder by stone mill, and sieving by a 60-;
peeling 10 parts by weight of Chinese yam and 17 parts by weight of baked ginger, cleaning, adding distilled water, grinding into slurry, stirring and mixing uniformly, and then passing through a spray dryer to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving the mixture by a 40-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain antidiarrheal layer 39.
The spray dryer comprises a cylindrical barrel 1, a feeding assembly and a charging assembly;
the top end face of the cylindrical barrel 1 is provided with a through hole 2, the lower surface of the top plate of the cylindrical barrel 1 is fixedly connected with a heating plate 15, the bottom end face of the cylindrical barrel 1 is downwards fixedly connected with at least two supporting plates 6, the heating plate 15 converts electric energy into heat energy, the structure and the working principle of the heating plate 15 are known, so repeated description is omitted, and the supporting plate 6 realizes the supporting effect on the cylindrical barrel 1;
the feeding assembly comprises at least two feeding boxes 3, the feeding boxes 3 are fixedly connected on the circumferential side wall of the cylindrical barrel 1, one end of each feeding box 3 is communicated with a feeding pipe 4, the other end of each feeding box 3 is communicated with a spray head 5, the spray heads 5 are communicated with the inside of the cylindrical barrel 1, a filter screen 7 is arranged in each feeding box 3, the upper end of each filter screen 7 is fixedly connected with a connecting plate 8, the upper end of each connecting plate 8 penetrates through the feeding box 3 and is fixedly connected with a ring plate 9, the ring plates 9 are detachably connected on the side wall of the cylindrical barrel 1, slurry of Chinese yams and baked gingers flows into the feeding boxes 3 through the feeding pipes 4, due to the effect of the filter screens 7, the Chinese yams and impurities in the baked gingers are prevented from flowing into the spray heads 5 to cause blockage of the spray heads 5, and due to the detachable connection of the ring plates 9 on the, the filter screen 7 and the connecting plate 8 are convenient to take down from the feeding box 3, so that the filter screen 7 and the feeding box 3 are convenient to clean;
the discharging assembly comprises a charging box 10, the charging box 10 is positioned at the lower end of the cylindrical barrel 1, the charging box 10 is detachably connected to the supporting plate 6, and the charging box 10 is detachably connected to the supporting plate 6, so that the charging box 10 can be conveniently installed and detached on the supporting plate 6 by workers.
The two ends of the connecting plate 8 are fixedly connected with sealing rings 12, the connecting plate 8 and the filter screen 7 are matched with the feeding box 3, and the sealing effect of the connecting plate 8 and the feeding box 3 is realized by the sealing rings 12;
the side wall of the through hole 2 is fixedly connected with a discharge cylinder 28, the inner side wall of the discharge cylinder 28 is horizontally and fixedly connected with a cooling pipe 29 filled with condensate, the circumferential outer side wall of the cooling pipe 29 is movably connected with scraping rings 30, and clamping rods 31 are fixedly connected between the scraping rings 30; the outer side wall of the discharging cylinder 28 is fixedly connected with a spring 32, one end of the spring 32 is fixedly connected with a T-shaped inserting rod 33, one end of the T-shaped inserting rod 33 penetrates through the side wall of the discharging cylinder 28 and is inserted on the outer side wall of the scraping ring 30, when liquid is contacted with the cooling pipe 29 in the discharging cylinder 28, due to the fact that cooling liquid is filled in the cooling pipe 29, the cooling effect is achieved, and the yam and ginger pulp which are deflected upwards are contacted with the cooling pipe 29 and attached to the outer side wall of the cooling pipe 29; when the attached Chinese yam and baked ginger serous fluid on the outer side wall of the cooling pipe 29 needs to be cleaned, a worker manually pulls the T-shaped insertion rod 33, when one end of the T-shaped insertion rod 33 is separated from the scraping ring 30, the worker manually pushes the scraping ring 30 again, the scraping ring 30 moves on the outer side wall of the cooling pipe 29, and when the scraping ring 30 moves on the cooling pipe 29, the attached Chinese yam and baked ginger serous fluid on the outer side wall of the cooling pipe 29 is cleaned.
The outer side wall of the scraping ring 30 is provided with a jack 34 for inserting the T-shaped inserting rod 33;
the side wall of the annular plate 9 is fixedly connected with a fixing block 13, the fixing block 13 is fixedly connected to the cylindrical barrel 1 through a fixing bolt 14, when the annular plate 9 needs to be taken down from the cylindrical barrel 1, a worker manually rotates the fixing bolt 14, and when one end of the fixing bolt 14 is taken down from the cylindrical barrel 1, the annular plate 9 can be taken down from the cylindrical barrel 1; when the annular plate 9 needs to be fixed on the cylindrical barrel 1, a worker places the annular plate 9 at a proper position, reversely rotates the fixing bolt 14, and fixedly connects the annular plate 9 on the cylindrical barrel 1 through the fixing bolt 14.
The lower end of the charging box 10 is fixedly connected with a sliding plate 16 through a phase connecting rod 11, the upper surface of the sliding plate 16 is fixedly connected with a motor 17, an output shaft of the motor 17 penetrates through the charging box 10 and is fixedly connected with a rotating rod 18, a connecting rod 19 is fixedly connected on the rotating rod 18, one end of the connecting rod 19 is fixedly connected with a stirring plate 20, the connecting rod 19 is movably connected with a scraping plate 21 matched with the inner side wall of the cylindrical barrel 1, the structure and the working principle of the motor 17 are known, so that detailed description is omitted, the motor 17 works, the stirring plate 20 is driven through the rotating rod 18, and when the stirring plate 20 rotates in the cylindrical barrel 1, Chinese yam and ginger liquid medicine sprayed in the cylindrical barrel 1 is; when the liquid medicine attached to the inner side wall of the cylindrical barrel 1 needs to be cleaned through the scraping plate 21, a worker adjusts the position of the scraping plate 21 to enable the scraping plate 21 to be in contact with the inner side wall of the cylindrical barrel 1, the motor 17 works to enable the scraping plate 21 to rotate on the inner side wall of the cylindrical barrel 1, and the scraping plate 21 cleans the liquid medicine attached to the inner side wall of the cylindrical barrel 1 when rotating;
a sliding groove 35 for slidably connecting the sliding plate 16 is formed in the side wall of the supporting plate 6, the sliding plate 16 is fixedly connected in the sliding groove 35 through a locking bolt 36, and the sliding groove 35 and the sliding plate 16 are arranged to facilitate the sliding plate 16 to move on the supporting plate 6;
the cartridge 10 is fixedly connected with a cylindrical block 22 for passing a driving shaft of the motor 17.
The scraper plate 21 is fixedly connected with cross rods 23, vertical rods 24 are fixedly connected between the cross rods 23, threaded rods 25 are fixedly connected to the side walls of the vertical rods 24, one ends of the threaded rods 25 penetrate through the side walls of the rotating rods 18 and are fixedly connected with fixed rods 26, nuts 27 are in threaded connection with the threaded rods 25 on the two sides of the rotating rods 18, when the position of the scraper 21 in the cylindrical barrel 1 needs to be adjusted, the worker moves the rotating rod 18 to the lower part of the cylindrical barrel 1, the worker manually rotates the nut 27, when the nut 27 is disengaged from the side wall of the turning rod 18, the worker manually moves the threaded rod 25, thereby realizing the adjustment of the position of the scraper plate 21 in the cylindrical barrel 1, when the scraper plate 21 is in the proper position in the cylindrical barrel 1, the worker manually turns the nut 27, and the scraper plate 21 is fixed in position by the nut 27.
When the yam and baked ginger drying device is used, when yam and baked ginger liquid medicine sprayed in the cylindrical barrel body 1 needs to be dried, a worker heats the cylindrical barrel body 1 through the heating plate 15, the worker enables the yam and baked ginger liquid medicine to flow into the feeding box 3 through the feeding pipe 4, the yam and baked ginger liquid medicine is sprayed in the cylindrical barrel body 1 through the spray head 5, the purpose of drying the yam and baked ginger liquid medicine is achieved through heating of the heating plate 15, and moisture in the yam and baked ginger liquid medicine is removed.
Meanwhile, the motor 17 works, and the stirring plate 20 rotates in the cylindrical barrel 1 through the rotating rod 18, so that the yam and the baked ginger serous fluid are uniformly stirred in the cylindrical barrel, and the yam and the baked ginger serous fluid are dried conveniently.
When the materials attached to the inner side wall of the cylindrical barrel 1 need to be cleaned, an operator rotates the locking bolt 36, when one end of the locking bolt 36 is separated from the sliding plate 16, the sliding plate 16 moves downwards, in the downward movement process of the sliding plate 16, the rotating rod 18, the cross rod 23 and the scraping plate 21 move downwards, when the rotating rod 18, the cross rod 23 and the scraping plate 21 move downwards to proper positions, the operator manually rotates the nut 27, when the nut 27 is separated from the side wall of the rotating rod 18, the operator manually moves the threaded rod 25, the position of the scraping plate 21 in the cylindrical barrel 1 is adjusted, when the scraping plate 21 is in the proper position in the cylindrical barrel 1, the operator manually rotates the nut 27, the scraping plate 21 is fixed in the proper position through the nut 27, then the operator moves the sliding plate 16 downwards, when the sliding plate 16 moves to the initial position, the locking bolt 36 is rotated reversely by the worker, the sliding plate 16 is locked through the locking bolt 36, the scraper plate 21 is rotated when the motor 17 works, and the materials attached to the inner side wall of the scraper plate 21 are cleaned when the scraper plate 21 rotates in the cylindrical barrel 1.
Example two
A veterinary drug for treating diarrhea of poultry comprises an anti-inflammatory layer 37, a sustained-release layer 38 and an antidiarrheal layer 39 bonded from outside to inside;
the anti-inflammatory layer 37 is prepared from the following raw materials in parts by weight: 12 parts of coptis chinensis, 30 parts of Chinese pulsatilla root, 15 parts of kudzuvine root, 15 parts of honeysuckle, 12 parts of cogongrass rhizome, 10 parts of weeping forsythia, 14 parts of baical skullcap root and 15 parts of heartleaf houttuynia herb;
the sustained-release layer 38 is prepared from the following raw materials in parts by weight: 85 parts of corn flour, 55 parts of soybean flour and 7 parts of adhesive;
the antidiarrheal layer 39 is prepared from the following raw materials in parts by weight: 4 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 20 parts of baked ginger, 13 parts of Chinese yam, 5 parts of astragalus membranaceus, 2 parts of angelica sinensis, 6 parts of white paeony root, 9 parts of corydalis tuber, 8 parts of elecampane, 7 parts of sanguisorba officinalis, 7 parts of halloysite, 15 parts of catechu and 15 parts of liquorice.
The binder is syrup.
The peripheral side wall of the anti-inflammatory layer 37 is adhered with a coating film;
the material of the coating film is hydroxypropyl methylcellulose.
The preparation method of the anti-inflammatory layer 37 comprises the following steps:
s1, cleaning rhizoma Coptidis, radix Pulsatillae, radix Puerariae, flos Lonicerae, rhizoma Imperatae, fructus forsythiae, radix Scutellariae, and herba Houttuyniae, air drying, and cutting into 5ccm long Chinese medicinal segments;
s2, drying the cut Chinese medicine segments in the S1 at 40 ℃ for 17min, then crushing in a crusher, and sieving with a 60-mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 60 ℃ for 17min while stirring;
s4, putting the stirred mixed raw material in the S3 into a pulverizer to be pulverized, and sieving the pulverized mixed raw material with a 120-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 170-mesh sieve to obtain the antiphlogistic powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer 37.
The preparation method of the sustained-release layer 38 comprises the following steps:
putting the corn kernels into a dryer, and drying for 25 minutes to reduce the moisture of the corn kernels to 13% to obtain dried corn kernels;
adding 7% of deionized water into the dried corn grains, stirring uniformly, standing for 12 minutes until the epidermis of the corn grains can be torn off by hands, and then placing the corn grains into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 130 meshes, and stopping crushing to obtain corn flour;
adding soybean powder and adhesive into corn flour, stirring, and drying to obtain delayed release layer 38.
The preparation method of the antidiarrheal layer 39 comprises the following steps:
removing impurities from radix Codonopsis, Atractylodis rhizoma, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, rhizoma corydalis, radix aucklandiae, radix Sangusorbae, Halloysitum rubrum, Catechu, and Glycyrrhrizae radix, cleaning, mixing, grinding into powder with stone mill, and sieving with 60 mesh sieve to obtain first mixed powder;
peeling rhizoma Dioscoreae and rhizoma Zingiberis Preparata, cleaning, adding distilled water, grinding into slurry, stirring, mixing, and spray drying to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving with a 50-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain antidiarrheal layer 39.
A preparation process of a veterinary drug for treating diarrhea of poultry, the preparation method of an anti-inflammatory layer 37 comprises the following steps:
s1, cleaning and airing 12 parts by weight of coptis chinensis, 30 parts by weight of Chinese pulsatilla root, 15 parts by weight of kudzu root, 15 parts by weight of honeysuckle, 12 parts by weight of cogongrass rhizome, 10 parts by weight of forsythia, 14 parts by weight of scutellaria baicalensis and 15 parts by weight of houttuynia cordata, and cutting into Chinese medicinal segments with the length of 5 ccm;
s2, drying the cut Chinese medicine segments in the S1 at 40 ℃ for 17min, then crushing in a crusher, and sieving with a 60-mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 60 ℃ for 17min while stirring;
s4, putting the stirred mixed raw material in the S3 into a pulverizer to be pulverized, and sieving the pulverized mixed raw material with a 120-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 170-mesh sieve to obtain the antiphlogistic powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer 37.
The preparation method of the sustained-release layer 38 comprises the following steps:
putting the corn kernels into a dryer, and drying for 25 minutes to reduce the moisture of the corn kernels to 13% to obtain dried corn kernels;
adding 7% of deionized water into the dried corn grains, stirring uniformly, standing for 12 minutes until the epidermis of the corn grains can be torn off by hands, and then placing the corn grains into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 130 meshes, and stopping crushing to obtain corn flour;
adding 55 parts by weight of soybean meal and 7 parts by weight of adhesive into 85 parts by weight of corn flour, uniformly stirring, and drying to obtain the slow-release layer 38.
The preparation method of the antidiarrheal layer 39 comprises the following steps:
removing impurities from raw materials respectively including 4 parts by weight of codonopsis pilosula, 10 parts by weight of bighead atractylodes rhizome, 5 parts by weight of astragalus, 2 parts by weight of angelica, 6 parts by weight of white paeony root, 9 parts by weight of corydalis tuber, 8 parts by weight of elecampane, 7 parts by weight of sanguisorba officinalis, 7 parts by weight of halloysite, 15 parts by weight of catechu and 15 parts by weight of liquorice, cleaning, uniformly mixing, grinding into powder by stone grinding, and sieving by a 60-mesh sieve to obtain first mixed powder;
peeling 13 parts by weight of Chinese yam and 20 parts by weight of baked ginger, cleaning, adding distilled water, grinding into slurry, stirring and mixing uniformly, and then passing through a spray dryer to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving with a 50-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain antidiarrheal layer 39.
The structure and the working principle of the spray dryer are the same as those of the first embodiment.
EXAMPLE III
A veterinary drug for treating diarrhea of poultry comprises an anti-inflammatory layer 37, a sustained-release layer 38 and an antidiarrheal layer 39 bonded from outside to inside;
the anti-inflammatory layer 37 is prepared from the following raw materials in parts by weight: 15 parts of coptis chinensis, 35 parts of Chinese pulsatilla root, 17 parts of kudzuvine root, 20 parts of honeysuckle, 15 parts of cogongrass rhizome, 15 parts of weeping forsythia, 19 parts of baical skullcap root and 17 parts of heartleaf houttuynia herb;
the sustained-release layer 38 is prepared from the following raw materials in parts by weight: 90 parts of corn flour, 60 parts of soybean flour and 10 parts of adhesive;
the antidiarrheal layer 39 is prepared from the following raw materials in parts by weight: 5 parts of codonopsis pilosula, 15 parts of bighead atractylodes rhizome, 25 parts of baked ginger, 15 parts of Chinese yam, 6 parts of astragalus membranaceus, 3 parts of angelica sinensis, 7 parts of white paeony root, 13 parts of corydalis tuber, 12 parts of elecampane, 8 parts of sanguisorba officinalis, 9 parts of halloysite, 23 parts of catechu and 20 parts of liquorice.
The binder is syrup.
The peripheral side wall of the anti-inflammatory layer 37 is adhered with a coating film;
the material of the coating film is hydroxypropyl methylcellulose.
The preparation method of the anti-inflammatory layer 37 comprises the following steps:
s1, cleaning rhizoma Coptidis, radix Pulsatillae, radix Puerariae, flos Lonicerae, rhizoma Imperatae, fructus forsythiae, radix Scutellariae, and herba Houttuyniae, air drying, and cutting into 5ccm long Chinese medicinal segments;
s2, drying the cut Chinese medicine segments in the S1 at 60 ℃ for 20min, then crushing in a crusher, and sieving with a 80-mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 80 ℃ for 15-20min while stirring;
s4, putting the stirred mixed raw material in the S3 into a pulverizer to be pulverized, and sieving the pulverized mixed raw material with a 130-mesh sieve;
s5, vibrating and micronizing the mixed powder sieved in the S4, and sieving the powder with a 180-mesh sieve to obtain the anti-inflammatory powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer 37.
The preparation method of the sustained-release layer 38 comprises the following steps:
putting the corn kernels into a dryer, and drying for 30 minutes to reduce the moisture of the corn kernels to 14% to obtain dried corn kernels;
adding 10% of deionized water into the dried corn grains, stirring uniformly, standing for 15 minutes until the epidermis of the corn grains can be torn off by hands, and then placing the corn grains into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 150 meshes, and stopping crushing to obtain corn flour;
adding soybean powder and adhesive into corn flour, stirring, and drying to obtain delayed release layer 38.
The preparation method of the antidiarrheal layer 39 comprises the following steps:
removing impurities from radix Codonopsis, Atractylodis rhizoma, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, rhizoma corydalis, radix aucklandiae, radix Sangusorbae, Halloysitum rubrum, Catechu, and Glycyrrhrizae radix, cleaning, mixing, grinding into powder with stone mill, and sieving with 60 mesh sieve to obtain first mixed powder;
peeling rhizoma Dioscoreae and rhizoma Zingiberis Preparata, cleaning, adding distilled water, grinding into slurry, stirring, mixing, and spray drying to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving by a 60-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain antidiarrheal layer 39.
A preparation process of a veterinary drug for treating diarrhea of poultry, the preparation method of an anti-inflammatory layer 37 comprises the following steps:
s1, cleaning and airing 15 parts by weight of coptis chinensis, 35 parts by weight of Chinese pulsatilla root, 17 parts by weight of kudzu root, 20 parts by weight of honeysuckle, 15 parts by weight of cogongrass rhizome, 15 parts by weight of forsythia, 19 parts by weight of scutellaria baicalensis and 17 parts by weight of houttuynia cordata, and cutting into Chinese medicinal segments with the length of 5 ccm;
s2, drying the cut Chinese medicine segments in the S1 at 60 ℃ for 20min, then crushing in a crusher, and sieving with a 80-mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 80 ℃ for 15-20min while stirring;
s4, putting the stirred mixed raw material in the S3 into a pulverizer to be pulverized, and sieving the pulverized mixed raw material with a 130-mesh sieve;
s5, vibrating and micronizing the mixed powder sieved in the S4, and sieving the powder with a 180-mesh sieve to obtain the anti-inflammatory powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer 37.
The preparation method of the sustained-release layer 38 comprises the following steps:
putting the corn kernels into a dryer, and drying for 30 minutes to reduce the moisture of the corn kernels to 14% to obtain dried corn kernels;
adding 10% of deionized water into the dried corn grains, stirring uniformly, standing for 15 minutes until the epidermis of the corn grains can be torn off by hands, and then placing the corn grains into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 150 meshes, and stopping crushing to obtain corn flour;
adding 60 parts by weight of soybean meal and 10 parts by weight of adhesive into 90 parts by weight of corn flour, uniformly stirring, and drying to obtain the slow-release layer 38.
The preparation method of the antidiarrheal layer 39 comprises the following steps:
removing impurities from raw materials of 5 parts by weight of codonopsis pilosula, 15 parts by weight of bighead atractylodes rhizome, 6 parts by weight of astragalus, 3 parts by weight of angelica, 7 parts by weight of white paeony root, 13 parts by weight of corydalis tuber, 12 parts by weight of elecampane, 8 parts by weight of sanguisorba officinalis, 9 parts by weight of halloysite, 23 parts by weight of catechu and 20 parts by weight of liquorice, cleaning, uniformly mixing, grinding into powder by stone grinding, and sieving by a 60-mesh sieve to obtain first mixed powder;
peeling 15 parts by weight of Chinese yam and 25 parts by weight of baked ginger, cleaning, adding distilled water, grinding into slurry, stirring and mixing uniformly, and then passing through a spray dryer to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving by a 60-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain antidiarrheal layer 39.
The structure and the working principle of the spray dryer are the same as those of the first embodiment.
The veterinary drug prepared in the first to third examples is used for treating diarrhea of poultry chicken, and the specific results are as follows:
group of Days (heaven) for poultry chicken to check diarrhea
Example one 2
Example two 1.5
EXAMPLE III 1.2
"fixedly connected" as described in the present invention means that two parts connected to each other are fixed together, typically by welding, screwing or gluing; "rotationally coupled" means that two components are coupled together and capable of relative motion.
Although the present description is described in terms of embodiments, not every embodiment includes only a single embodiment, and such description is for clarity only, and those skilled in the art should be able to integrate the description as a whole, and the embodiments can be appropriately combined to form other embodiments as will be understood by those skilled in the art.
Therefore, the above description is only a preferred embodiment of the present application, and is not intended to limit the scope of the present application; all changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims (10)

1. A veterinary drug for treating diarrhea of poultry is characterized in that the veterinary drug comprises an anti-inflammatory layer, a sustained-release layer and an antidiarrheal layer which are bonded from outside to inside;
the anti-inflammatory layer is prepared from the following raw materials in parts by weight: 10-15 parts of coptis chinensis, 20-35 parts of Chinese pulsatilla root, 9-17 parts of kudzu root, 10-20 parts of honeysuckle, 10-15 parts of cogongrass rhizome, 3-15 parts of fructus forsythiae, 8-19 parts of scutellaria baicalensis and 13-17 parts of houttuynia cordata;
the slow release layer is prepared from the following raw materials in parts by weight: 80-90 parts of corn flour, 50-60 parts of soybean meal and 5-10 parts of adhesive;
the antidiarrheal layer is prepared from the following raw materials in parts by weight: 3-5 parts of codonopsis pilosula, 5-15 parts of bighead atractylodes rhizome, 17-25 parts of baked ginger, 10-15 parts of Chinese yam, 3-6 parts of astragalus membranaceus, 1-3 parts of angelica sinensis, 5-7 parts of white paeony root, 5-13 parts of corydalis tuber, 5-12 parts of elecampane, 5-8 parts of sanguisorba officinalis, 5-9 parts of halloysite, 9-23 parts of catechu and 10-20 parts of liquorice.
2. The veterinary drug for treating diarrhea in poultry according to claim 1, wherein said binder is syrup.
3. The veterinary drug for treating the diarrhea of the poultry according to claim 1, wherein the peripheral side wall of the anti-inflammatory layer is adhered with a coating film;
the coating film is made of hydroxypropyl methylcellulose.
4. The veterinary drug for treating diarrhea in poultry according to claim 1, wherein the preparation method of the anti-inflammatory layer comprises the following steps:
s1, cleaning rhizoma Coptidis, radix Pulsatillae, radix Puerariae, flos Lonicerae, rhizoma Imperatae, fructus forsythiae, radix Scutellariae, and herba Houttuyniae, air drying, and cutting into segments of 3-5ccm long;
s2, drying the cut Chinese medicine segments in the S1 at 50-60 ℃ for 15-20min, then crushing in a crusher, and sieving with a 50-80 mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 70-80 ℃ for 15-20min while stirring;
s4, putting the mixed raw material after stirring in the S3 into a pulverizer for pulverization, and sieving the pulverized raw material with a 100-mesh and 130-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 150-mesh and 180-mesh sieve to obtain the anti-inflammatory powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain the anti-inflammatory layer.
5. The veterinary drug for treating the diarrhea of poultry according to claim 1, wherein the preparation method of the sustained-release layer comprises the following steps:
putting the corn kernels into a dryer, and drying for 20-30 minutes to reduce the moisture of the corn kernels to 12-14% to obtain dried corn kernels;
adding 5-10% deionized water into the dried corn grains, stirring, standing for 10-15 min until the epidermis of the corn grains can be torn off by hand, and placing into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 120-;
adding soybean powder and adhesive into corn flour, stirring, and drying to obtain the delayed release layer.
6. The veterinary drug for treating the diarrhea of poultry according to claim 1, wherein the preparation method of the antidiarrheal layer comprises the following steps:
removing impurities from radix Codonopsis, Atractylodis rhizoma, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, rhizoma corydalis, radix aucklandiae, radix Sangusorbae, Halloysitum rubrum, Catechu, and Glycyrrhrizae radix, cleaning, mixing, grinding into powder with stone mill, and sieving with 60 mesh sieve to obtain first mixed powder;
peeling rhizoma Dioscoreae and rhizoma Zingiberis Preparata, cleaning, adding distilled water, grinding into slurry, stirring, mixing, and spray drying to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving with a 40-60-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain the antidiarrheal layer.
7. A preparation process of a veterinary drug for treating poultry diarrhea is characterized by comprising the following steps: the veterinary drug comprises an anti-inflammatory layer, a sustained-release layer and an antidiarrheal layer which are bonded from outside to inside;
the preparation method of the anti-inflammatory layer comprises the following steps:
s1, cleaning and airing 10-15 parts of coptis chinensis, 20-35 parts of Chinese pulsatilla root, 9-17 parts of kudzu vine root, 10-20 parts of honeysuckle, 10-15 parts of cogongrass rhizome, 3-15 parts of weeping forsythia capsule, 8-19 parts of scutellaria baicalensis and 13-17 parts of houttuynia cordata, and cutting into Chinese medicinal segments with the length of 3-5 ccm;
s2, drying the cut Chinese medicine segments in the S1 at 50-60 ℃ for 15-20min, then crushing in a crusher, and sieving with a 50-80 mesh sieve;
s3, uniformly mixing the raw material powder sieved in the S2, and then drying the mixture at 70-80 ℃ for 15-20min while stirring;
s4, putting the mixed raw material after stirring in the S3 into a pulverizer for pulverization, and sieving the pulverized raw material with a 100-mesh and 130-mesh sieve;
s5, vibrating and superfine-crushing the mixed powder sieved in the S4, and sieving the crushed mixed powder with a 150-mesh and 180-mesh sieve to obtain the anti-inflammatory powder;
s6, adding distilled water into the anti-inflammatory powder, uniformly stirring, drying and solidifying to obtain an anti-inflammatory layer;
the preparation method of the sustained-release layer comprises the following steps:
putting the corn kernels into a dryer, and drying for 20-30 minutes to reduce the moisture of the corn kernels to 12-14% to obtain dried corn kernels;
adding 5-10% deionized water into the dried corn grains, stirring, standing for 10-15 min until the epidermis of the corn grains can be torn off by hand, and placing into a peeling and gritting machine to obtain corn grits;
placing the corn grits into a bulking machine for high-temperature curing and sterilization to obtain a coarse corn semi-finished product for later use;
crushing the semi-finished corn product by using a centrifugal grinder until the fineness is 120-;
adding 50-60 parts by weight of soybean meal and 5-10 parts by weight of adhesive into 80-90 parts by weight of corn flour, uniformly stirring, and drying to obtain a slow-release layer;
the preparation method of the antidiarrheal layer comprises the following steps:
removing impurities from 3-5 parts of codonopsis pilosula, 5-15 parts of bighead atractylodes rhizome, 3-6 parts of astragalus membranaceus, 1-3 parts of angelica, 5-7 parts of radix paeoniae alba, 5-13 parts of rhizoma corydalis, 5-12 parts of elecampane, 5-8 parts of sanguisorba officinalis, 5-9 parts of halloysite, 9-23 parts of catechu and 10-20 parts of liquorice, cleaning, uniformly mixing, grinding into powder by using a stone mill, and sieving by using a 60-mesh sieve to obtain first mixed powder;
peeling 10-15 parts by weight of Chinese yam and 17-25 parts by weight of baked ginger, cleaning, adding distilled water, grinding into slurry, stirring and mixing uniformly, and then passing through a spray dryer to obtain second mixed powder;
uniformly mixing the first mixed powder and the second mixed powder, and sieving with a 40-60-mesh sieve to obtain antidiarrheal powder;
adding starch slurry into the antidiarrheal powder, stirring, and drying to obtain the antidiarrheal layer.
8. The process for the preparation of a veterinary drug for the treatment of diarrhea in poultry according to claim 7, wherein the spray dryer comprises a cylindrical barrel (1), a feeding assembly and a charging assembly;
the top end surface of the cylindrical barrel (1) is provided with a through hole (2), the lower surface of the top plate of the cylindrical barrel (1) is fixedly connected with a heating plate (15), and the bottom end surface of the cylindrical barrel (1) faces downwards and is fixedly connected with at least two supporting plates (6);
the feeding assembly comprises at least two feeding boxes (3), the feeding boxes (3) are fixedly connected to the circumferential side wall of the cylindrical barrel (1), one ends of the feeding boxes (3) are communicated with feeding pipes (4), the other ends of the feeding boxes (3) are communicated with spray heads (5), the spray heads (5) are communicated with the inside of the cylindrical barrel (1), a filter screen (7) is arranged in the feeding boxes (3), the upper end of the filter screen (7) is fixedly connected with a connecting plate (8), the upper end of the connecting plate (8) penetrates through the feeding boxes (3) and is fixedly connected with an annular plate (9), and the annular plate (9) is detachably connected to the side wall of the cylindrical barrel (1);
the discharging assembly comprises a charging box (10), the charging box (10) is positioned at the lower end of the cylindrical barrel (1), and the charging box (10) is detachably connected to the supporting plate (6).
9. The preparation process of the veterinary drug for treating the diarrhea of the poultry according to the claim 8, wherein the two ends of the connecting plate (8) are fixedly connected with sealing rings (12), and the sealing rings (12), the connecting plate (8) and the filter screen (7) are matched with the feeding box (3);
the side wall of the through hole (2) is fixedly connected with a discharging cylinder (28), the inner side wall of the discharging cylinder (28) is horizontally and fixedly connected with a cooling pipe (29) filled with condensate, the circumferential outer side wall of the cooling pipe (29) is movably connected with scraping rings (30), and clamping rods (31) are fixedly connected between the scraping rings (30); a spring (32) is fixedly connected to the outer side wall of the discharging cylinder (28), one end of the spring (32) is fixedly connected with a T-shaped insertion rod (33), and one end of the T-shaped insertion rod (33) penetrates through the side wall of the discharging cylinder (28) and is inserted into the outer side wall of the scraping ring (30);
the outer side wall of the scraping ring (30) is provided with a jack (34) for inserting a T-shaped inserting rod (33);
the side wall of the annular plate (9) is fixedly connected with a fixing block (13), and the fixing block (13) is fixedly connected to the cylindrical barrel (1) through a fixing bolt (14).
10. The preparation process of the veterinary drug for treating the poultry diarrhea according to claim 8, wherein the lower end of the loading box (10) is fixedly connected with a sliding plate (16) through a phase connecting rod (11), the upper surface of the sliding plate (16) is fixedly connected with a motor (17), an output shaft of the motor (17) penetrates through the loading box (10) and is fixedly connected with a rotating rod (18), a connecting rod (19) is fixedly connected on the rotating rod (18), one end of the connecting rod (19) is fixedly connected with a stirring plate (20), and the connecting rod (19) is movably connected with a scraping plate (21) matched with the inner side wall of the cylindrical barrel (1);
a sliding groove (35) for sliding connection of the sliding plate (16) is formed in the side wall of the supporting plate (6), and the sliding plate (16) is fixedly connected into the sliding groove (35) through a locking bolt (36);
the charging box (10) is fixedly connected with a cylindrical block (22) for a driving shaft of a motor (17) to penetrate through;
scrape fixedly connected with horizontal pole (23) on flitch (21), fixedly connected with montant (24) between horizontal pole (23), fixedly connected with threaded rod (25) on the lateral wall of montant (24), lateral wall and fixedly connected with dead lever (26) of dwang (18) are passed to the one end of threaded rod (25), are located equal threaded connection has nut (27) on threaded rod (25) of dwang (18) both sides.
CN201911077587.5A 2019-11-06 2019-11-06 Veterinary drug for treating poultry diarrhea and preparation process thereof Withdrawn CN110664981A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114452322A (en) * 2022-03-16 2022-05-10 新乡学院 Anti-diarrhea compound artemisia-pueraria traditional Chinese medicine composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114452322A (en) * 2022-03-16 2022-05-10 新乡学院 Anti-diarrhea compound artemisia-pueraria traditional Chinese medicine composition
CN114452322B (en) * 2022-03-16 2022-12-09 新乡学院 Anti-diarrhea compound artemisia-pueraria traditional Chinese medicine composition

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