CN110664846A - 一种蜂胶酒及其制备方法 - Google Patents

一种蜂胶酒及其制备方法 Download PDF

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Publication number
CN110664846A
CN110664846A CN201911072082.XA CN201911072082A CN110664846A CN 110664846 A CN110664846 A CN 110664846A CN 201911072082 A CN201911072082 A CN 201911072082A CN 110664846 A CN110664846 A CN 110664846A
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China
Prior art keywords
propolis
radix
chinese medicinal
medicinal composition
traditional chinese
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CN201911072082.XA
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English (en)
Inventor
王小芳
郑光辉
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Jinjiang Honeybee Health Service Co Ltd
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Jinjiang Honeybee Health Service Co Ltd
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Priority to CN201911072082.XA priority Critical patent/CN110664846A/zh
Publication of CN110664846A publication Critical patent/CN110664846A/zh
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    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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Abstract

本发明涉及药用酒技术领域，具体涉及一种蜂胶酒及其制备方法，一种蜂胶酒的制备方法，包括如下步骤：(1)将天然蜂胶冷冻，粉碎成粉末状；将中药组合物进行超微粉碎；(2)放入酒精中浸泡，静置过滤，得到蜂胶清液；(3)将残渣放入酒精中浸泡，静置过滤，得到蜂胶液；(4)将蜂胶清液和蜂胶液混合，再加入高粱酒进行充分混合调匀，陈化，制得蜂胶酒；所述步骤(1)中，中药组合物为降血糖中药组合物、降血脂中药组合物、保肝利胆中药组合物和养心安神中药组合物中的至少一种。本发明的蜂胶酒对于临床上细菌感染、病毒感染、高血压以及提高癌症患者免疫力以及预防复发具有显著疗效，还具有降血糖、降血脂、保肝利胆和养心安神等作用。

Description

一种蜂胶酒及其制备方法
技术领域
本发明涉及药用酒技术领域，具体涉及一种蜂胶酒及其制备方法。
背景技术
蜂胶为蜜蜂科动物中华蜜蜂等修补蜂巢所分泌的黄褐色或黑褐色的粘性物质。蜂胶含树脂约50％-60％，蜂蜡30％芳香挥发油10％和一些花粉等夹杂物。主要有黄酮类、酚类、内酯、香豆精类、醛、酮、甾类化合物，还含有维生素B1、烟酸、维生素A原和多种氨基酸、糖、多糖等，及必需元素34种：氧、碳、氢、钙、磷、氮、钾、硫、钠、氯、镁、铁、钴、铜、钼、氟、铝、锡、硅、砷、硒、钛、钒、铬、镍、钡、锆、锑、镉、银、铅、锶等。有“黄酮类化合物的宝库”和“紫色黄金”的美誉，黄酮类物质具有抗菌、抗病毒、抗肿瘤、抗炎症、免疫调节、抗氧化等的活性，被广泛应用于食品、药品、化妆品领域。现有技术中记载的蜂胶的几大作用：
(1)有抗菌作用：蜂胶能灭菌、杀菌、消毒、抑菌、防霉、防腐，解决了抗生素只对单一微生物起作用具的缺陷，且没有副作用。在日常生活中对皮肤病有很好的治疗效果。
(2)抗病毒作用：蜂胶是天然的抗病毒物质，对多种病毒都有很强的抑制和杀灭作用。
(3)抗氧化作用：蜂胶被称为抗氧化剂和自由基清除剂，能够有效清除因肥胖、过度劳累、环境污染、吸烟等不良生活习惯和外界因素产生的过剩活性氧和自由基等废物。
(4)增强免疫力作用：人体的免疫系统容易被病毒侵害，蜂胶能够增强人体免疫力，增强人体抵抗病毒侵害的能力。
(5)抗癌作用：国内外大量的研究表明，蜂胶中含有丰富的抗癌物质，研究证明，癌症患者在服用蜂胶后，可缩小癌细胞且能减轻化疗、放疗引起的副作用。
(6)促进细胞再生作用：蜂胶能够加快组织再生和伤口的愈合。美容养颜作用。蜂胶能够分解色素、平复皱纹、减缓衰老等，是女性美容佳品。
(7)抗高血压：患有高血压的患者连续服用含非常多的黄酮类物质及具有非常强抗氧化能力的蜂胶，不仅可以减少过氧化脂质对血管的危害，防止血管硬化，而且还能有效地降低甘油三脂的含量，减少血小板聚集，改善微循环，可以降低过高的血压，防止意外事情的发生。
由此可见，蜂胶是滋补佳品，有不同程度提高免疫力、抗肿瘤作用，因此，如何运用中医理论组方将蜂胶与其它中药组合物有机配伍后，再利用现代化的药化、药理知识，尽可能完全将其中的有效成分完全提取出来，以获得对患者有益的产品，是现有技术亟待解决的问题。
发明内容
为了克服现有技术中存在的缺点和不足，本发明的目的在于提供一种蜂胶酒的制备方法，该制备方法采用乙醇浸提，能极大程度提取出天然蜂胶和中药组合物中的有效物质，还能有效提高提取率，步骤简单，操作控制方便，质量稳定。
本发明的另一目的在于提供一种蜂胶酒，该蜂胶酒对于临床上细菌感染、病毒感染、高血压以及提高癌症患者免疫力以及预防复发具有显著疗效，还具有降血糖、降血脂、保肝利胆和养心安神等作用。
本发明的目的通过下述技术方案实现：一种蜂胶酒的制备方法，包括如下步骤：
(1)原料粉碎：将天然蜂胶150-250g冷冻2-4天，取出后进行粉碎或用锤子砸成粉末状；将中药组合物进行超微粉碎，粉碎至粒径为10-50μm；
(2)一次浸泡：将粉碎后的天然蜂胶和中药组合物放入600-1000g酒精中浸泡3天以上，每天摇晃2-6次，浸泡时的外界环境温度在20℃以上，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入150-250g酒精中浸泡3天以上，每天摇晃2-6次，浸泡时的外界环境温度在20℃以上，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入300-500g高粱酒进行充分混合调匀，陈化1-6个月，制得蜂胶酒；
所述步骤(1)中，中药组合物为降血糖中药组合物、降血脂中药组合物、保肝利胆中药组合物和养心安神中药组合物中的至少一种。
优选的，所述降血糖中药组合物包括山药3-5g、地骨皮1-2g、葛根2-4g、黄芩1.5-2.5g、五味子1-3g、知母1.5-2.5g、玉竹1-2g、黄芪2.5-3.5g、玄参1-2g和枸杞子2-3g。本发明的降血糖中药组合物通过采用上述中药配伍，并严格控制各中药原料的重量配比，制得的蜂胶酒具有降血糖的功效。更为优选的，所述降血糖中药组合物包括山药4.5g、地骨皮1.5g、葛根3g、黄芩2g、五味子2g、知母2g、玉竹1.5g、黄芪3g、玄参1.5g和枸杞子2.5g。
优选的，所述降血脂中药组合物包括细辛2-4g、山楂3-5g、红花2-3g、当归1-2g、何首乌1.5-2.5g、桔梗2-4g、姜黄1-3g、金银花2-3g和金樱子1-2g。本发明的降血脂中药组合物通过采用上述中药配伍，并严格控制各中药原料的重量配比，制得的蜂胶酒具有降血脂的功效。更为优选的，所述降血脂中药组合物包括细辛3g、山楂4g、红花2.5g、当归1.5g、何首乌2g、桔梗3g、姜黄2g、金银花2.5g和金樱子1.5g。
优选的，所述保肝利胆中药组合物包括柴胡2-3g、生地1-2g、黄柏1.5-2.5g、穿心莲1-2g、大青叶0.5-1.5g、龙胆草1-3g、蒲公英2-5g、山栀子2-3g和白花蛇舌草2-4g。本发明的保肝利胆中药组合物通过采用上述中药配伍，并严格控制各中药原料的重量配比，制得的蜂胶酒具有具有保肝利胆的功效。更为优选的，所述保肝利胆中药组合物包括柴胡2.5g、生地1.5g、黄柏2g、穿心莲1.5g、大青叶1g、龙胆草2g、蒲公英3.5g、山栀子2.5g和白花蛇舌草3g。
优选的，所述养心安神中药组合物包括远志1-2g、茯苓2-3g、丹参1-2g、酸枣仁3-5g、五味子1.5-2.5g、柏子仁2-4g、合欢皮1-3g、夜交藤2.5-3.5g和龙眼肉2-4g。本发明的养心安神中药组合物通过采用上述中药配伍，并严格控制各中药原料的重量配比，制得的蜂胶酒具有养心安神的功效。更为优选的，所述养心安神中药组合物包括远志1.5g、茯苓2.5g、丹参1.5g、酸枣仁4g、五味子2g、柏子仁3g、合欢皮2g、夜交藤3g和龙眼肉3g。
本发明的另一目的通过下述技术方案实现：一种蜂胶酒，所述蜂胶酒根据上述所述的制备方法制得。
本发明的有益效果在于：本发明的制备方法采用乙醇浸提，能极大程度提取出天然蜂胶和中药组合物中的有效物质，还能有效提高提取率，步骤简单，操作控制方便，质量稳定。
本发明的蜂胶酒对于临床上细菌感染、病毒感染、高血压以及提高癌症患者免疫力以及预防复发具有显著疗效，还具有降血糖、降血脂、保肝利胆和养心安神等作用。
具体实施方式
为了便于本领域技术人员的理解，下面结合实施例对本发明作进一步的说明，实施方式提及的内容并非对本发明的限定。
对比例1
一种蜂胶酒的制备方法，包括如下步骤：
(1)原料粉碎：将天然蜂胶150g冷冻2天，取出后进行粉碎或用锤子砸成粉末状；
(2)一次浸泡：将粉碎后的天然蜂胶放入600g酒精中浸泡4天，每天摇晃2次，浸泡时的外界环境温度在22℃，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入150g酒精中浸泡4天，每天摇晃2次，浸泡时的外界环境温度在22℃，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入300g高粱酒进行充分混合调匀，陈化2个月，制得蜂胶酒；
一种蜂胶酒，所述蜂胶酒根据上述所述的制备方法制得。
本发明对比例1没有加入中药组合物制得的蜂胶酒给予临床化疗病人口服，空腹服用，饭前或者饭后半小时服用20mL，每日早、中、晚各一次。实验病例共55例，其中无效2例，好转23例，有效30例，起效率为96.4％。
实施例1
一种蜂胶酒的制备方法，包括如下步骤：
(1)原料粉碎：将天然蜂胶180g冷冻3天，取出后进行粉碎或用锤子砸成粉末状；将中药组合物进行超微粉碎，粉碎至粒径为20μm；
(2)一次浸泡：将粉碎后的天然蜂胶和中药组合物放入700g酒精中浸泡5天，每天摇晃3次，浸泡时的外界环境温度在25℃，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入180g酒精中浸泡5天，每天摇晃3次，浸泡时的外界环境温度在25℃，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入350g高粱酒进行充分混合调匀，陈化3个月，制得蜂胶酒；
所述步骤(1)中，中药组合物为降血糖中药组合物；所述降血糖中药组合物包括山药4.5g、地骨皮1.5g、葛根3g、黄芩2g、五味子2g、知母2g、玉竹1.5g、黄芪3g、玄参1.5g和枸杞子2.5g。
一种蜂胶酒，所述蜂胶酒根据上述所述的制备方法制得。
本发明实施例1加入降血糖中药组合物制得的蜂胶酒给予临床高血糖患者口服，空腹服用，饭前或者饭后半小时服用20mL，每日早、中、晚各一次。实验病例共63例，其中无效3例，好转26例，有效34例，起效率为98.4％。
例2
一种蜂胶酒的制备方法，包括如下步骤：
(1)原料粉碎：将天然蜂胶200g冷冻3天，取出后进行粉碎或用锤子砸成粉末状；将中药组合物进行超微粉碎，粉碎至粒径为30μm；
(2)一次浸泡：将粉碎后的天然蜂胶和中药组合物放入800g酒精中浸泡6天，每天摇晃4次，浸泡时的外界环境温度在28℃，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入200g酒精中浸泡6天，每天摇晃4次，浸泡时的外界环境温度在28℃，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入400g高粱酒进行充分混合调匀，陈化4个月，制得蜂胶酒；
所述步骤(1)中，中药组合物为降血脂中药组合物，所述降血脂中药组合物包括细辛3g、山楂4g、红花2.5g、当归1.5g、何首乌2g、桔梗3g、姜黄2g、金银花2.5g和金樱子1.5g。
一种蜂胶酒，所述蜂胶酒根据上述所述的制备方法制得。
本发明实施例2加入降血脂中药组合物制得的蜂胶酒给予临床高血脂患者口服，空腹服用，饭前或者饭后半小时服用20mL，每日早、中、晚各一次。实验病例共43例，其中无效1例，好转19例，有效23例，起效率为97.7％。
实施例3
一种蜂胶酒的制备方法，包括如下步骤：
(1)原料粉碎：将天然蜂胶220g冷冻3天，取出后进行粉碎或用锤子砸成粉末状；将中药组合物进行超微粉碎，粉碎至粒径为40μm；
(2)一次浸泡：将粉碎后的天然蜂胶和中药组合物放入90g酒精中浸泡7天，每天摇晃5次，浸泡时的外界环境温度在32℃，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入220g酒精中浸泡7天，每天摇晃5次，浸泡时的外界环境温度在32℃，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入450g高粱酒进行充分混合调匀，陈化5个月，制得蜂胶酒；
所述步骤(1)中，中药组合物为保肝利胆中药组合物，所述保肝利胆中药组合物包括柴胡2.5g、生地1.5g、黄柏2g、穿心莲1.5g、大青叶1g、龙胆草2g、蒲公英3.5g、山栀子2.5g和白花蛇舌草3g。
一种蜂胶酒，所述蜂胶酒根据上述所述的制备方法制得。
本发明实施例3加入保肝利胆中药组合物制得的蜂胶酒给予临床肝炎病人口服，空腹服用，饭前或者饭后半小时服用20mL，每日早、中、晚各一次。实验病例共47例，其中无效2例，好转20例，有效25例，起效率为95.7％。
实施例4
一种蜂胶酒的制备方法，包括如下步骤：
(1)原料粉碎：将天然蜂胶250g冷冻4天，取出后进行粉碎或用锤子砸成粉末状；将中药组合物进行超微粉碎，粉碎至粒径为50μm；
(2)一次浸泡：将粉碎后的天然蜂胶和中药组合物放入1000g酒精中浸泡8天，每天摇晃6次，浸泡时的外界环境温度在35℃，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入250g酒精中浸泡8天，每天摇晃6次，浸泡时的外界环境温度在35℃，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入500g高粱酒进行充分混合调匀，陈化6个月，制得蜂胶酒；
所述步骤(1)中，中药组合物为养心安神中药组合物，所述养心安神中药组合物包括远志1.5g、茯苓2.5g、丹参1.5g、酸枣仁4g、五味子2g、柏子仁3g、合欢皮2g、夜交藤3g和龙眼肉3g。
一种蜂胶酒，所述蜂胶酒根据上述所述的制备方法制得。
本发明实施例4加入养心安神中药组合物制得的蜂胶酒给予临床失眠患者口服，空腹服用，饭前或者饭后半小时服用20mL，每日早、中、晚各一次。实验病例共51例，其中无效1例，好转22例，有效28例，起效率为98.0％。
本发明制得的蜂胶酒对于临床上提高癌症患者免疫力以及预防复发具有显著疗效，还对高血糖、高血脂、肝炎和失眠等症状有显著疗效。
上述实施例为本发明较佳的实现方案，除此之外，本发明还可以其它方式实现，在不脱离本发明构思的前提下任何显而易见的替换均在本发明的保护范围之内。

Claims (10)

1.一种蜂胶酒的制备方法，其特征在于：包括如下步骤：
(1)原料粉碎：将天然蜂胶150-250g冷冻2-4天，取出后进行粉碎或用锤子砸成粉末状；将中药组合物进行超微粉碎，粉碎至粒径为10-50μm；
(2)一次浸泡：将粉碎后的天然蜂胶和中药组合物放入600-1000g酒精中浸泡3天以上，每天摇晃2-6次，浸泡时的外界环境温度在20℃以上，静置1天，过滤，得到蜂胶清液；
(3)二次浸泡：将步骤(2)过滤后的残渣放入150-250g酒精中浸泡3天以上，每天摇晃2-6次，浸泡时的外界环境温度在20℃以上，静置1天，过滤，得到蜂胶液；
(4)混合陈化：将步骤(2)过滤得到的蜂胶清液和步骤(3)过滤得到的蜂胶液混合，再加入300-500g高粱酒进行充分混合调匀，陈化1-6个月，制得蜂胶酒；
所述步骤(1)中，中药组合物为降血糖中药组合物、降血脂中药组合物、保肝利胆中药组合物和养心安神中药组合物中的至少一种。
2.根据权利要求1所述的一种蜂胶酒的制备方法，其特征在于：所述降血糖中药组合物包括山药3-5g、地骨皮1-2g、葛根2-4g、黄芩1.5-2.5g、五味子1-3g、知母1.5-2.5g、玉竹1-2g、黄芪2.5-3.5g、玄参1-2g和枸杞子2-3g。
3.根据权利要求2所述的一种蜂胶酒的制备方法，其特征在于：所述降血糖中药组合物包括山药4.5g、地骨皮1.5g、葛根3g、黄芩2g、五味子2g、知母2g、玉竹1.5g、黄芪3g、玄参1.5g和枸杞子2.5g。
4.根据权利要求1所述的一种蜂胶酒的制备方法，其特征在于：所述降血脂中药组合物包括细辛2-4g、山楂3-5g、红花2-3g、当归1-2g、何首乌1.5-2.5g、桔梗2-4g、姜黄1-3g、金银花2-3g和金樱子1-2g。
5.根据权利要求4所述的一种蜂胶酒的制备方法，其特征在于：所述降血脂中药组合物包括细辛3g、山楂4g、红花2.5g、当归1.5g、何首乌2g、桔梗3g、姜黄2g、金银花2.5g和金樱子1.5g。
6.根据权利要求1所述的一种蜂胶酒的制备方法，其特征在于：所述保肝利胆中药组合物包括柴胡2-3g、生地1-2g、黄柏1.5-2.5g、穿心莲1-2g、大青叶0.5-1.5g、龙胆草1-3g、蒲公英2-5g、山栀子2-3g和白花蛇舌草2-4g。
7.根据权利要求6所述的一种蜂胶酒的制备方法，其特征在于：所述保肝利胆中药组合物包括柴胡2.5g、生地1.5g、黄柏2g、穿心莲1.5g、大青叶1g、龙胆草2g、蒲公英3.5g、山栀子2.5g和白花蛇舌草3g。
8.根据权利要求1所述的一种蜂胶酒的制备方法，其特征在于：所述养心安神中药组合物包括远志1-2g、茯苓2-3g、丹参1-2g、酸枣仁3-5g、五味子1.5-2.5g、柏子仁2-4g、合欢皮1-3g、夜交藤2.5-3.5g和龙眼肉2-4g。
9.根据权利要求8所述的一种蜂胶酒的制备方法，其特征在于：所述养心安神中药组合物包括远志1.5g、茯苓2.5g、丹参1.5g、酸枣仁4g、五味子2g、柏子仁3g、合欢皮2g、夜交藤3g和龙眼肉3g。
10.一种蜂胶酒，其特征在于：所述蜂胶酒根据权利要求1-9任一项所述的制备方法制得。
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