CN110664832A - Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof - Google Patents

Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof Download PDF

Info

Publication number
CN110664832A
CN110664832A CN201911126929.8A CN201911126929A CN110664832A CN 110664832 A CN110664832 A CN 110664832A CN 201911126929 A CN201911126929 A CN 201911126929A CN 110664832 A CN110664832 A CN 110664832A
Authority
CN
China
Prior art keywords
vitamin
coating
folic acid
tablet
tablet core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911126929.8A
Other languages
Chinese (zh)
Inventor
陈斌
陈国靖
汪善文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XUANCHENG BAIWEILI BIOLOGICAL ENGINEERING CO LTD
Original Assignee
XUANCHENG BAIWEILI BIOLOGICAL ENGINEERING CO LTD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XUANCHENG BAIWEILI BIOLOGICAL ENGINEERING CO LTD filed Critical XUANCHENG BAIWEILI BIOLOGICAL ENGINEERING CO LTD
Priority to CN201911126929.8A priority Critical patent/CN110664832A/en
Publication of CN110664832A publication Critical patent/CN110664832A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The vitamin B6 vitamin B12 folic acid tablet comprises a tablet core and a coating, wherein the tablet core comprises folic acid, cyanocobalamine 1%, pyridoxine hydrochloride, microcrystalline cellulose PH102, lactose and magnesium stearate in parts by weight, and the coating mainly composed of coating powder is coated outside the tablet core. The invention has the beneficial effects that: the vitamin B6 vitamin B12 folic acid tablet can comprehensively supplement vitamin B6 vitamin B12 folic acid and prevent cerebrovascular diseases, is designed to be swallowed and is convenient to carry; the finished product prepared by the preparation method has high qualification rate, and the waste of raw materials is reduced.

Description

Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof
Technical Field
The invention relates to the field of health-care food, in particular to a vitamin B6 vitamin B12 folic acid tablet and a preparation method thereof.
Background
Cerebrovascular diseases are brain diseases caused by various cerebrovascular diseases, and can be classified into ischemic brain, stroke and hemorrhagic stroke according to the pathological nature. At home and abroad, it is acknowledged that the deficiency of folic acid, vitamin B6 and vitamin B12 can cause homocysteinemia and increase the risk of cerebrovascular diseases, and the deficiency of folic acid, vitamin B6 and vitamin B12 is a risk factor for causing cerebrovascular diseases.
Folic acid, vitamin B6 and vitamin B12 are important coenzymes for metabolism of homocysteine in vivo, and in order to reduce serum homocysteine concentration, the vitamin B supplementing method can be adopted. The research on folic acid, vitamin B6, vitamin B12 and homocysteine can help to prevent and treat cerebrovascular diseases.
At present, most of products in the market, including pharmaceutical preparations, exist in a single mode, and no compound product which is mainly used for prevention is definitely appeared. Therefore, the emergence of vitamin B6 vitamin B12 folic acid tablets can certainly generate important clinical significance.
Disclosure of Invention
In order to solve the technical problems, the invention provides vitamin B6, vitamin B12 and folic acid tablets and a preparation method thereof, which can comprehensively supplement vitamin B6, vitamin B12 and folic acid and prevent cerebrovascular diseases. It is designed to be swallowed and is convenient to carry.
The invention relates to a vitamin B6 vitamin B12 folic acid tablet, which adopts the technical scheme that: the tablet core mainly comprises a tablet core and a coating, wherein the tablet core comprises folic acid, cyanocobalamine 1% (vitamin B12), pyridoxine hydrochloride (vitamin B6), microcrystalline cellulose PH102, lactose and magnesium stearate according to parts by weight, and the coating mainly comprises coating powder.
Further, the vitamin B6 vitamin B12 folic acid tablet is designed into a tablet shape, the tablet core of each tablet is 250mg, and the tablet comprises the following components: 0.48mg folic acid, 0.31mg cyanocobalamin 1%, 4.01mg pyridoxine hydrochloride, 144.5mg microcrystalline cellulose pH102, 98.2mg lactose and 2.5mg magnesium stearate.
Further, the coating outside each tablet core contains: 7.5mg coating powder.
A preparation method of vitamin B6 vitamin B12 folic acid tablets comprises the following steps:
1) mixing: mixing folic acid, 1% of cyanocobalamine and pyridoxine hydrochloride by hand for 3 minutes according to the formula amount, sieving with an 80-mesh sieve, and then gradually mixing with microcrystalline cellulose PH102 according to the equivalent amount for three times, and sieving with the 80-mesh sieve each time to obtain a first mixture;
2) total mixing: the first mixture was then sequentially fed into a mixer with the remaining microcrystalline cellulose PH102, lactose, set to: rotating at a speed of 10 r/min for 5min, stopping the machine, adding magnesium stearate in a prescribed amount, continuously mixing for 5min, stopping the machine after mixing, obtaining granules to be subjected to tabletting, and transferring the granules to a tabletting room or an intermediate station for tabletting and temporarily storing;
3) tabletting: putting the total mixed granules to be tabletted into a punch die of a high-speed tabletting machine for tabletting to obtain tablet cores;
4) sampling and detecting;
5) coating: placing 6.14kg of purified water in a slurry preparation container of a coating machine, starting stirring to keep the solution in a vortex shape, slowly adding 1kg of pink coating powder into the purified water, and continuously stirring for 45 minutes to obtain a coating solution;
putting the tablet core into a coating machine for coating, and drying the finished product for 5-10 minutes;
6) packaging: and packaging the finished product.
Further, in the step 3), the punch die is in a circular shallow arc shape, and the diameter of the punch die is 8 mm.
Further, in the step 3), the average tablet weight of the obtained tablet cores is checked every 15 min; checking the weight of each slice every 30min, and taking 10 slices each time; and simultaneously checking whether the appearance meets the requirement, wherein the difference of the tablet weight is 231mg-268mg (+ -7.5%), the hardness is 80-150N, the friability is less than 0.5%, the disintegration time is within 30min, and the tablet cores which do not meet the condition are scrapped according to unqualified products.
Further, in the step 5), the conditions of coating the tablet core by the coating machine are set as that the rotating speed of a coating pan is 2-5r/min, the preheating tablet bed is 35-45 ℃, the air inlet temperature is 60-70 ℃, the air outlet temperature is 30-40 ℃, the air return is negative pressure and atomization pressure which are used for keeping 0.02-0.10KPa in the coating machine: 0.40-0.60MPa, and the spraying speed of the spray gun of the coating machine is 5-15 HZ.
The invention has the beneficial effects that: the vitamin B6 vitamin B12 folic acid tablet can comprehensively supplement vitamin B6 vitamin B12 folic acid and prevent cerebrovascular diseases, is designed to be swallowed and is convenient to carry; the finished product prepared by the preparation method has high qualification rate, and the waste of raw materials is reduced.
Drawings
In order that the present invention may be more readily and clearly understood, a more particular description of the invention briefly described above will be rendered by reference to specific embodiments that are illustrated in the appended drawings.
FIG. 1 is a first batch test report of vitamin B6 vitamin B12 folic acid tablets according to the present invention.
Fig. 2 is a second batch test report sheet of vitamin B6, vitamin B12 folic acid tablets according to the present invention.
Fig. 3 is a third batch test report sheet of vitamin B6, vitamin B12 folic acid tablets according to the present invention.
Detailed Description
As shown in fig. 1-3, the vitamin B6 vitamin B12 folic acid tablet of the present invention comprises a tablet core and a coating, wherein each 250mg tablet core comprises: 0.48mg folic acid, 0.31mg cyanocobalamin 1%, 4.01mg pyridoxine hydrochloride, 144.5mg microcrystalline cellulose PH102, 98.2mg lactose and 2.5mg magnesium stearate, the core being coated with a coating consisting of 7.5mg coating powder.
A preparation method of vitamin B6 vitamin B12 folic acid tablets comprises the following steps:
1) mixing: mixing folic acid, 1% of cyanocobalamine and pyridoxine hydrochloride by hand for 3 minutes according to the formula amount, sieving with an 80-mesh sieve, and then gradually mixing with microcrystalline cellulose PH102 according to the equivalent amount for three times, and sieving with the 80-mesh sieve each time to obtain a first mixture;
because no mechanical equipment meeting the requirements can accurately finish the equivalent incremental mixing of trace elements at present, the equivalent incremental mixing of three elements of folic acid, cyanocobalamin 1 percent and pyridoxine hydrochloride is manually finished according to production batches in the step 1) according to the batches of each batch, so that the actual production operation is more convenient and accurate;
mixing the microcrystalline cellulose PH102 three times through a mixing device (model of a mixer: HDJ-15) according to the principle that the output of each batch is increased in equal quantity, mixing three trace elements in equal quantity to the three elements in equal quantity, mixing the mixed elements in equal quantity with the microcrystalline cellulose, and increasing the mixing quantity of each time step by step in equal ratio, so that the stability of functional components and the uniformity of particles of the product can be ensured, and the quality of the product is more stable;
2) total mixing: the first mixture was then sequentially fed into a mixer with the remaining microcrystalline cellulose PH102 and direct lactose press, set to: rotating at a speed of 10 r/min for 5min, stopping the machine, adding magnesium stearate in a prescribed amount, continuously mixing for 5min, stopping the machine for blanking after mixing is finished to obtain total mixed granules to be tabletted, packaging the granules by a double-layer PE bag, and then transferring the granules to a tabletting room or an intermediate station for tabletting and temporarily storing;
the mixer adopted in the embodiment is an HZD type mixer produced by Tianjin Hanlin aerospace science and technology development Limited;
3) tabletting: putting the total mixed granules to be tabletted into a punch die of a high-speed tabletting machine for tabletting to obtain a tablet core;
in the embodiment, a GZPS-51 full-automatic double-discharging high-speed tablet press is adopted, the model of the punch die is MG-001, the punch die is in a circular shallow arc shape, and the diameter of the punch die is 8 mm;
checking the average tablet weight of the obtained tablet core every 15 min; checking the weight of each slice every 30min, and taking 10 slices each time; checking whether the appearance meets the requirement, wherein the tablet weight is 250mg-268mg (preferably 250mg or above, ensuring that the net content meets the requirement), the hardness is 80-150N, the friability is less than 0.5%, the disintegration time is within 30min, and the thickness of the tablet core is 4 mm;
4) sampling and detecting;
5) coating: placing 6.14kg of purified water in a slurry preparation container of a coating machine, starting stirring to keep the solution in a vortex shape, slowly adding 1kg of pink coating powder into the purified water, and continuously stirring for 45 minutes to obtain a coating solution;
placing the tablet core into JBG-150C/JBG-350E high-efficiency sugar-coating film coating machine manufactured by Wenzhou Jianpai pharmaceutical machinery science and technology Limited company, wherein the rotating speed of a coating pan is 2-5r/min, the tablet bed is preheated by 35-45 ℃, the air inlet temperature is 60-70 ℃, the air outlet temperature is 30-40 ℃, the air return is the negative pressure and the atomization pressure which are used for keeping 0.02-0.10KPa in the coating machine: coating the tablet core under the conditions of 0.40-0.60MPa and the spraying speed of a spray gun of a coating machine of 5-15HZ, drying the finished product for 5-10 minutes after coating, and discharging;
6) packaging: and packaging the finished product.
The formula amount for producing 2 ten thousand vitamin B6 vitamin B12 folic acid tablets is shown in the following table 1:
Figure BDA0002277141950000041
the qualification rate of finished products for producing 2 ten thousand vitamin B6 vitamin B12 folic acid tablets is shown in the following table 2:
fig. 1-3 are 3 batch test reports of vitamin B6 vitamin B12 folic acid tablets according to the present invention.
From the above table and fig. 1-3, it can be known that the finished product prepared by the preparation method has high qualification rate, meets the requirements of related technical standards, effectively reduces the waste of raw materials, improves the stability of the product in shelf life, and better ensures the product quality.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and all equivalent variations made by using the contents of the present specification and the drawings are within the protection scope of the present invention.

Claims (7)

1. The vitamin B6 vitamin B12 folic acid tablet is characterized by comprising a tablet core and a coating, wherein the tablet core comprises folic acid, cyanocobalamine 1%, pyridoxine hydrochloride, microcrystalline cellulose PH102, lactose and magnesium stearate in parts by weight, and the coating mainly consisting of coating powder is coated outside the tablet core.
2. The vitamin B6 vitamin B12 folic acid tablet of claim 1, wherein each 250mg tablet core contains: 0.48mg folic acid, 0.31mg cyanocobalamin 1%, 4.01mg pyridoxine hydrochloride, 144.5mg microcrystalline cellulose pH102, 98.2mg lactose and 2.5mg magnesium stearate.
3. A vitamin B6 vitamin B12 folic acid tablet according to claim 2, characterized in that the coating outside each tablet core contains: 7.5mg coating powder.
4. The process for preparing vitamin B6 vitamin B12 folic acid tablets of claim 1, 2 or 3, comprising the steps of:
1) mixing: mixing folic acid, 1% of cyanocobalamine and pyridoxine hydrochloride by hand for 3 minutes according to the formula amount, sieving with an 80-mesh sieve, and then gradually mixing with microcrystalline cellulose PH102 according to the equivalent amount for three times, and sieving with the 80-mesh sieve each time to obtain a first mixture;
2) total mixing: the first mixture was then sequentially fed into a mixer with the remaining microcrystalline cellulose PH102, lactose, set to: rotating at a speed of 10 r/min for 5min, stopping the machine, adding magnesium stearate in a prescribed amount, continuously mixing for 5min, stopping the machine after mixing, obtaining granules to be subjected to tabletting, and transferring the granules to a tabletting room or an intermediate station for tabletting and temporarily storing;
3) tabletting: putting the total mixed granules to be tabletted into a punch die of a high-speed tabletting machine for tabletting to obtain tablet cores;
4) sampling and detecting;
5) coating: placing 6.14kg of purified water in a slurry preparation container of a coating machine, starting stirring to keep the solution in a vortex shape, slowly adding 1kg of pink coating powder into the purified water, and continuously stirring for 45 minutes to obtain a coating solution;
putting the tablet core into a coating machine for coating, closing a spray gun of the coating machine after coating is finished, reducing the rotating speed, drying the finished product for 5-10 minutes and discharging;
6) packaging: and packaging the finished product.
5. The method for preparing vitamin B6 vitamin B12 folic acid tablets according to claim 4, wherein in the step 3), the punch die is in a circular shallow arc shape with the diameter of 8 mm.
6. The method for preparing vitamin B6 vitamin B12 folic acid tablets according to the claim 4, characterized in that in the step 3), the average tablet weight of the obtained tablet cores is checked every 15 min; checking the weight of each slice every 30min, and taking 10 slices each time; and simultaneously checking whether the appearance meets the requirements, wherein the difference of the tablet weight is 231mg-268mg, the hardness is 80-150N, the friability is less than 0.5%, the disintegration time is within 30min, and the thickness of the tablet core is 4 mm.
7. The preparation method of the vitamin B6, vitamin B12 and folic acid tablet as claimed in claim 4, wherein in the step 5), the conditions of the coating machine for coating the tablet core are set as the following, namely the rotation speed of a coating pan is 2-5r/min, the preheating tablet bed is 35-45 ℃, the air inlet temperature is 60-70 ℃, the air outlet temperature is 30-40 ℃, the air return is a negative pressure and the atomization pressure for keeping 0.02-0.10KPa in the coating machine: 0.40-0.60MPa, and the spraying speed of the spray gun of the coating machine is 5-15 HZ.
CN201911126929.8A 2019-11-18 2019-11-18 Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof Pending CN110664832A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911126929.8A CN110664832A (en) 2019-11-18 2019-11-18 Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911126929.8A CN110664832A (en) 2019-11-18 2019-11-18 Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof

Publications (1)

Publication Number Publication Date
CN110664832A true CN110664832A (en) 2020-01-10

Family

ID=69087716

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911126929.8A Pending CN110664832A (en) 2019-11-18 2019-11-18 Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof

Country Status (1)

Country Link
CN (1) CN110664832A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897706A (en) * 2009-05-27 2010-12-01 北京奥萨医药研究中心有限公司 Composition containing folic acid and B vitamins and applications thereof
CN105962379A (en) * 2016-05-03 2016-09-28 宣城柏维力生物工程有限公司 Vitamin B tablets and preparation method thereof
CN109498643A (en) * 2018-12-06 2019-03-22 北京斯利安药业有限公司 A kind of folate composition and its application in the old mistake intelligence drug of preparation improvement

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897706A (en) * 2009-05-27 2010-12-01 北京奥萨医药研究中心有限公司 Composition containing folic acid and B vitamins and applications thereof
CN105962379A (en) * 2016-05-03 2016-09-28 宣城柏维力生物工程有限公司 Vitamin B tablets and preparation method thereof
CN109498643A (en) * 2018-12-06 2019-03-22 北京斯利安药业有限公司 A kind of folate composition and its application in the old mistake intelligence drug of preparation improvement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
关志宇主编: "微晶纤维素", 《药物制剂辅料与包装材料》 *
张双庆主编: "乳糖", 《特殊医学用途配方食品理论与实践》 *

Similar Documents

Publication Publication Date Title
CN101579325B (en) Metformin hydrochloride controlled-release tablet and preparation method thereof
CN102058554B (en) Method for preparing sustained-release tablets through granulating by adopting bonding agents in atomizing states
CN110538153A (en) High-stability and quick-release solid preparation and preparation method thereof
CN103479592B (en) Metformin hydrochloride sustained release tablets and preparation method thereof
CN102302076A (en) Synsepalum dulcificum natural taste-changing candies and preparation method thereof
CN110711181B (en) Tinidazole tablet and preparation method thereof
CN112494440A (en) Sitagliptin phosphate tablet and preparation method thereof
CN110664832A (en) Vitamin B6 vitamin B12 folic acid tablet and preparation method thereof
CN113679673A (en) Production process of ibuprofen sustained and controlled release pellet
CN107982231B (en) Trimetazidine hydrochloride tablet and preparation method thereof
CN110151719A (en) A kind of Li Gelieting piece preparation process
CN102836135A (en) Aspirin enteric-coated tablet and preparation process thereof
CN108309948A (en) Cetirizine hydrochloride Tablets and preparation method thereof
CN102614143B (en) High-stability vitamin C tablet and preparing process thereof
RU2719728C9 (en) Specialized food product for improving memorizing and reproduction processes and a method for production thereof
CN106176649B (en) Folic acid VB12 tablet and preparation method thereof
CN113694041B (en) Process for preparing medicinal sucrose pill core
CN102652534A (en) Preparation method of compound trace element sustained-release pill for flocks and herds
CN109364033B (en) Mercaptopurine quartering chewable tablet and preparation method thereof
CN103446163B (en) Compound preparation Ah coffee sheet that a kind of free salicylic acid content is low and preparation method thereof
CN113288878B (en) Cloperidine hydrochloride tablet and preparation method thereof
CN103284973A (en) Adefovir dipivoxil composition and preparation method thereof
CN110720632A (en) Nutrient composition for late pregnancy and preparation method and application thereof
Lordi et al. Compaction of pharmaceuticals
CN112826803B (en) Levocarnitine tablets and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20200110

RJ01 Rejection of invention patent application after publication