CN102652534A - Preparation method of compound trace element sustained-release pill for flocks and herds - Google Patents
Preparation method of compound trace element sustained-release pill for flocks and herds Download PDFInfo
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- CN102652534A CN102652534A CN2011100555783A CN201110055578A CN102652534A CN 102652534 A CN102652534 A CN 102652534A CN 2011100555783 A CN2011100555783 A CN 2011100555783A CN 201110055578 A CN201110055578 A CN 201110055578A CN 102652534 A CN102652534 A CN 102652534A
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Abstract
The invention relates to a preparation method of a compound trace element sustained-release pill for flocks and herds. The method comprises the following steps of: carefully choosing raw materials, detecting the content of raw materials, stirring and mixing, weighing, pressing in a mould and demoulding to obtain the finished product of the sustained-release pill. The finished product of the sustained-release pill prepared by the method is mainly used for controlling the diseases in the nutrition metabolism of ruminants and supplementing related trace elements. Data indicates that the preparation method is unique, quick and convenient to use, and safe and efficient; and the quality is controllable. The pill can be slowly released for 10-12 months in an animal body, and the aim of supplementing trace elements for long term is achieved.
Description
Technical field
The invention belongs to a kind of method for preparing ruminant microelement kind feed addictive.
Background technology
The main preparation methods of animal Rare Elements Preparations commonly used has ion-exchange-resin process at present; With the beeswax is the casting method of adhesive; With palygorskite, montmorillonite is the ion-exchange of carrier; And the mixed method for making of carrier melting etc. is dissolved in the slowly-releasing control.Because the certain defective of above method existence in various degree; Common defects like casting method and the mixed method for making of the molten carrier melting of slowly-releasing control is that quality of the pharmaceutical preparations control is affected under the situation that ambient temperature changes; The microelement kind preparation slow release effect that these class methods are prepared is poor; Rate of release is fast in animal body, is prone to cause that the animal body selenium and other trace elements poisons, and is very little because the biomedical characteristic of selenium element shows its effective dose and toxic dose scope.Ion-exchange is because the difference of carrier; The kind and the formulation that have limited such preparation element are more single, are confined to oral formulations, injection and embedding preparation etc. basically, its complex manufacturing; The automation mechanized operation difficulty is big; Cost of manufacture is higher, in production reality, is difficult to realize its large-scale production, has environmental pollution hidden danger.Therefore, people carry out exploratory development to the preparation method of composite trace element class sustained release preparation constantly in recent years.
Summary of the invention
For solving the many areas of China owing to microelement deficiencies cause cattle and sheep microelement deficiencies class Nutrition and Metabolism disease higher; Have a strong impact on the quality of production performance, comprehensive benefit, meat products and the dairy products of cattle and sheep, the development of cattle and sheep aquaculture is caused enormous economic loss; Existing micro-arbitrary way exists mainly that complementary element is single, release time short, throw that the clothes mode falls behind and the preparation method's of Rare Elements Preparations defective, and the object of the invention aims to provide a kind of preparation method of cattle and sheep compound trace-element slow-release bullet.
The objective of the invention is to accomplish like this:
A kind of preparation method of cattle and sheep compound trace-element slow-release bullet the steps include:
A. brown iron oxide is crossed vibratory sieve, was removed thick fines and foreign material, and adding zinc stearate, calcium sulphate dihydrate, trace elements of selenium, zinc, copper in proportion is the different powder of granularity, goes into the V-arrangement batch mixer, and mixing is for use;
B. get the batch mixing weighing, it is 10 grams that sheep is used the slowly-releasing ball, and it is 30 grams that ox is used the slowly-releasing ball;
c. would weigh filling mixture into the sheep were sustained-release pill chrome vanadium steel mold, or cow with a slow-release pill chrome vanadium steel mold;
D. put install powder mould under 100 tons of hydraulic presses, compacting, the demoulding, taking-up the slowly-releasing ball.
The present invention is base-material with the brown iron oxide.Brown iron oxide is shape, granularity different powder, and under mould constraint and forcing press crunch, ferrous powder granules distortion, the changing of the relative positions be bonding, melt and form for the slowly-releasing ball of countless slight void is arranged.And these spaces just in time hold the more tiny trace element of granularity, and calcium sulphate dihydrate is the control solvent, and zinc stearate is a releasing agent.The present invention's compacting forms the slowly-releasing bullet.Be mainly used in the control of ruminant animal nutrition metabolism class disease and replenishing of relevant trace element thereof.
The beneficial effect of advantage of the present invention and generation:
The present invention is a kind of preparation method of lasting compound trace-element slow-release pill of ruminant use; The slowly-releasing ball is by copper, iron, zinc, 4 kinds of trace elements of selenium, and weight substance brown iron oxide, excipient zinc stearate and slowly-releasing control thereof are dissolved carrier calcium sulphate dihydrate composition after 100 tons of hydraulic presses compactings form.The compound trace-element slow-release bullet of this law preparation and like product compare have efficient, slow-release time reach 10-12 individual month, easy to control the quality, security performance is high; Be convenient to production practical application characteristics; Reach the purpose of long-term microelement-supplementing, for the healthy sustainable development of cattle and sheep production reality and animal husbandry provides technical support.After the slowly-releasing ball finished product demoulding of compression moulding, need not to dry in the air, dry by the fire, reach PROCESS FOR TREATMENT such as sintering.By the new and effective cattle and sheep compound trace-element slow-release agent that selenium, copper, zinc various trace elements are formed, the present invention and existing preparation compare, and its advantage mainly embodies like following table 1.
The performance of the agent of table 1 cattle and sheep composite slow release and other preparation relatively
Data this content of reporting for work is not seen in "---" expression.
Can find out from table 1: because cattle and sheep compound trace-element slow-release bullet is to form through 100 tons of hydraulic press compactings.The slow-release time of slowly-releasing bullet, dispensing target spot are compared with existing injection, glass ball and oral capsule, and performance all will be got well.
Description of drawings
Fig. 1 is a cattle and sheep composite slow release preparation production technique flow diagram of the present invention.
The specific embodiment
In conjunction with accompanying drawing, technical scheme of the present invention is further described again:
As shown in Figure 1, a kind of preparation method of cattle and sheep compound trace-element slow-release bullet the steps include:
A. brown iron oxide is crossed 60 order vibratory sieves, the removal foreign material are crossed meal, removed fines after 150 order vibratory sieves.Brown iron oxide, zinc stearate, calcium sulphate dihydrate, selenium, zinc, copper were in 145: 1: 2: 10: 20: 20 ratios, go into the V-arrangement batch mixer, and mixing is for use.Trace elements of selenium, zinc, shot copper degree are 300 purpose powders,
B. get the batch mixing weighing, it is 10 grams that sheep is used the slowly-releasing ball, and it is 30 grams that ox is used the slowly-releasing ball.
c. the weighed mixture were filled into a sustained-release pellets sheep chrome vanadium steel mold, or in sustained-release pellets bovine chrome vanadium steel mold, the mold for the height of 60 mm, 50 mm diameter, 20 mm hollow tube shape;
D. put install powder mould under 100 tons of hydraulic presses, compacting, the demoulding, taking-up the slowly-releasing ball; The slowly-releasing ball of making is that the two ends dimpling is cylindrical: sheep is with heavy 10 grams, 13 millimeters of length, 12 millimeters of diameters; Ox is with heavy 30 grams, 20 millimeters of length, 20 millimeters of diameters.
The slowly-releasing bullet of preparation is thrown the clothes device through special use and is directly thrown into the cattle and sheep cud; In the cattle and sheep body, slowly discharge; The balanced required trace element of animal body that replenishes; Once throwing clothes slowly-releasing 1 year (maintenance 10-12 month) overcomes defectives such as complementary element was single in the past, release time short, throwing clothes mode falls behind, and is superior to like product.
Claims (1)
1. the preparation method of a cattle and sheep compound trace-element slow-release bullet the steps include:
A. brown iron oxide is crossed vibratory sieve, was removed thick fines and foreign material, and adding zinc stearate, calcium sulphate dihydrate, trace elements of selenium, zinc, copper in proportion is the different powder of granularity, goes into the V-arrangement batch mixer, and mixing is for use;
B. get the batch mixing weighing, it is 10 grams that sheep is used the slowly-releasing ball, and it is 30 grams that ox is used the slowly-releasing ball;
c. would weigh filling mixture into the sheep were sustained-release pill chrome vanadium steel mold, or cow with a slow-release pill chrome vanadium steel mold;
D. put install powder mould under 100 tons of hydraulic presses, compacting, the demoulding, taking-up the slowly-releasing ball.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100555783A CN102652534A (en) | 2011-03-04 | 2011-03-04 | Preparation method of compound trace element sustained-release pill for flocks and herds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100555783A CN102652534A (en) | 2011-03-04 | 2011-03-04 | Preparation method of compound trace element sustained-release pill for flocks and herds |
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| CN102652534A true CN102652534A (en) | 2012-09-05 |
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| CN2011100555783A Pending CN102652534A (en) | 2011-03-04 | 2011-03-04 | Preparation method of compound trace element sustained-release pill for flocks and herds |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523681A (en) * | 2014-12-17 | 2015-04-22 | 南京农业大学 | Parasite expelling sustained and controlled-release bolus and preparation method thereof |
| CN109965102A (en) * | 2019-02-27 | 2019-07-05 | 王允瑞 | A kind of cattle and sheep trace-element slow-release pill and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85102343A (en) * | 1984-08-30 | 1986-10-29 | 特罗本维克有限公司和科隆分公司 | The method for preparing pellet-formulation |
| CN1225797A (en) * | 1998-02-12 | 1999-08-18 | 刘必超 | Lang-lasting compound trace-element slow-release pill for ruminant |
| CN1439361A (en) * | 2002-05-22 | 2003-09-03 | 青海省畜牧兽医科学院 | Nutritive sustained release ball for ruminant |
| WO2010029571A2 (en) * | 2008-07-30 | 2010-03-18 | Panacea Biotec Limited | Modified release ramipril compositions and uses thereof |
-
2011
- 2011-03-04 CN CN2011100555783A patent/CN102652534A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85102343A (en) * | 1984-08-30 | 1986-10-29 | 特罗本维克有限公司和科隆分公司 | The method for preparing pellet-formulation |
| CN1225797A (en) * | 1998-02-12 | 1999-08-18 | 刘必超 | Lang-lasting compound trace-element slow-release pill for ruminant |
| CN1439361A (en) * | 2002-05-22 | 2003-09-03 | 青海省畜牧兽医科学院 | Nutritive sustained release ball for ruminant |
| WO2010029571A2 (en) * | 2008-07-30 | 2010-03-18 | Panacea Biotec Limited | Modified release ramipril compositions and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王宝山，等: "缓释丸在反刍动物中的研究与应用", 《饲料研究》, no. 12, 31 December 2002 (2002-12-31), pages 19 - 20 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523681A (en) * | 2014-12-17 | 2015-04-22 | 南京农业大学 | Parasite expelling sustained and controlled-release bolus and preparation method thereof |
| CN109965102A (en) * | 2019-02-27 | 2019-07-05 | 王允瑞 | A kind of cattle and sheep trace-element slow-release pill and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20120905 |