CN110663821A - Preparation method of coated guanidinoacetic acid - Google Patents
Preparation method of coated guanidinoacetic acid Download PDFInfo
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- CN110663821A CN110663821A CN201910984268.6A CN201910984268A CN110663821A CN 110663821 A CN110663821 A CN 110663821A CN 201910984268 A CN201910984268 A CN 201910984268A CN 110663821 A CN110663821 A CN 110663821A
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- Prior art keywords
- coated
- preparation
- guanidinoacetic acid
- coating
- glycocyamine
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
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- Fodder In General (AREA)
Abstract
A preparation method of coated glycocyamine takes glycocyamine and a coating material as raw materials, the coating material is sprayed on the surface of granular glycocyamine through a bottom spraying system of a coating machine, and the preparation method comprises the following steps: (1) pre-treating; (2) preparing a pill core; (3) primary coating; (4) secondary coating; the method optimizes the process of coating glycocyamine, comprises the selection of auxiliary materials and the selection of all parameters in the preparation process, can prepare the coated glycocyamine with good stability and high bioavailability by the method, particularly for ruminants, reduces the degradation rate of the product in rumen, achieves the effect of slow release after passing through the rumen, and has high bioavailability. The invention is suitable for the field of preparation of feed additives.
Description
Technical Field
The invention belongs to the field of preparation of feed additives, and particularly relates to a preparation method of coated guanidinoacetic acid.
Background
The glycocyamine belongs to amino acid and derivatives thereof, is a functional feed additive, and is suitable for livestock and poultry mainly based on plant daily ration. The glycocyamine has important effects of improving the production performance of livestock and poultry, improving the meat quality, promoting energy metabolism, improving the resource value of protein feed and the like. Most guanidinoacetic acid obtained by the existing preparation method is in a powder crystal shape, the flowability is poor in practical use, particularly, the product has high degradation rate in rumen in the aspect of ruminant utilization, the sustained-release effect cannot be achieved after the product passes through the rumen, and the bioavailability is low.
Disclosure of Invention
The invention aims to provide a preparation method of coated glycocyamine, which protects glycocyamine through technical treatment, prevents glycocyamine from being fermented and degraded in a rumen to directly enter a small intestine and then be digested and absorbed, and thus achieves the purpose of improving the utilization rate of glycocyamine.
A preparation method of coated guanidinoacetic acid comprises the following preparation steps:
(1) pretreatment of
Carrying out superfine grinding and screening on the guanidinoacetic acid to obtain guanidinoacetic acid powder;
(2) preparation of pellet core
Placing guanidinoacetic acid powder and gelatinized starch solution into hydroxypropyl methyl cellulose solution, uniformly mixing, then preparing into spherical particles, screening the spherical particles, and then putting into a dryer for drying to obtain pill cores;
(3) primary coating
Putting the pellet cores into a particle coating machine, primarily coating by adopting a bottom spraying mode and ethyl cellulose alcohol solution or polyacrylic resin IV alcohol solution as a coating material to obtain primarily coated pellet cores, and screening the primarily coated pellet cores;
(4) secondary coating
Placing the screened primary coated pellet core particles in a fluidized bed coating machine, melting the food-grade hydrogenated vegetable oil through a bottom spraying system of the fluidized bed coating machine, and then using the melted food-grade hydrogenated vegetable oil as a coating material to carry out secondary coating on the primary coated pellet core, thereby obtaining the coated glycocyamine.
As a limitation of step (1), selecting powder guanidinoacetic acid from guanidinoacetic acid in the step (1); and carrying out swing arrangement and grading screening on the glycocyamine through a sieve of 80 meshes, and taking glycocyamine powder of 80 meshes.
As the limitation of the step (2), the starch in the step (2) is any plant starch, preferably corn starch or potato starch, and the starch accounts for 0.4 percent ~ 0.6.6 percent of the mass of the pellet core.
As a second limitation of step (2), hydroxypropyl methylcellulose constitutes 0.4% ~ 0.6.6%, preferably 0.4%, of the mass of the pellet core in step (2);
the concentration of the hydroxypropyl methylcellulose solution is 10% ~ 15%, preferably 10%.
As a third limitation of the step (2), the spherical particles formed in the step (2) are subjected to swing finishing and classification screening by a 20-mesh ~ 60-mesh screen;
the parameters in the dryer in the step (2) are that the air inlet speed is 80 ~ 85 ℃, the air outlet speed is 60 ~ 80 ℃, and the drying time is 15 ~ 30 minutes.
As a limitation of the step (3), the adding mass ratio of the pellet core to the ethyl cellulose or polyacrylic resin IV in the step (3) is 21.5 ~ 28: 1;
the concentration of the ethyl cellulose alcohol solution is 20 percent ~ 40 percent, preferably 20 percent, and the concentration of the polyacrylic resin IV alcohol solution is 5 percent ~ 8 percent, preferably 5 percent
The parameters of the particle coating machine are that the air inlet temperature is less than 85 ℃, the material temperature is less than 80 ℃, the atomization pressure is 0.80 MPa ~ 0.90.90 MPa, and the pump flow rate is 15 ~ 30 L.h-1Treatment time of 30 ~ 45 minutes;
in the step (3), the primarily coated pellet cores are subjected to swinging, granulating and grading screening by a sieve with 20 meshes and ~ 60 meshes.
As a limitation of step (4), the food grade hydrogenated vegetable oil in step (4) has a melting temperature of 65 ℃ ~ 100 ℃;
the addition mass ratio of the sieved primary coating pellet core particles to the food-grade hydrogenated vegetable oil is 2.5 ~ 12.5.5: 1;
the parameters of the fluidized bed coating machine are that the air inlet temperature is less than 65 ℃, the material temperature is less than 45 ℃, the atomization pressure is 0.20 MPa ~ 0.25.25 MPa, and the pump flow rate is 15 ~ 30 L.h-1The treatment time was 30 ~ 45 minutes.
And (3) as a second limitation of the step (4), after the secondary coating of the step (4) is finished, carrying out swing arrangement and classification screening by using a 40-mesh screen to obtain the coated guanidinoacetic acid on oversize products.
By way of limitation, the appearance of the finally obtained product is in a strip shape or an oval shape, and the effective component of glycocyamine after secondary coating reaches 60 percent ~ 90 percent.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
(1) after the glycocyamine is coated, the glycocyamine has good free-running property and is easy to process feed;
(2) the glycocyamine is protected by multiple coatings, the rumen bypass rate of glycocyamine active ingredients is improved, the glycocyamine is prevented from being fermented and degraded in rumen and directly entering small intestine and then being digested and absorbed, and the utilization rate of glycocyamine is improved;
(3) the degradation rate of the guanidinoacetic acid in rumen is reduced, the slow release effect of the product is realized, and the bioavailability of the product is improved;
(4) after being coated for many times, the product has better stability, is beneficial to storage, and resists abrasion in the processing process and high temperature in the feed granulating process.
Drawings
The invention is described in further detail below with reference to the figures and the embodiments.
FIG. 1 is a process flow diagram of the preparation method of the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Examples 1 to 6A coated guanidinoacetic acid
Examples 1 to 6 are each a coated guanidinoacetic acid, the raw material formulation of which is shown in Table I.
TABLE A raw Material formulation for examples 1-6
Example 7 preparation of coated guanidinoacetic acid
This example, which was used to prepare guanidinoacetic acid as described in any of examples 1 to 6, comprises the following steps carried out in succession:
(1) pretreatment of
Superfine grinding powder of glycocyamine, then carrying out swing finishing and grading screening by using an 80-mesh screen, and taking glycocyamine which passes through 80 meshes as a raw material;
(2) preparation of pellet core
Placing 400 parts of crushed and sieved powder glycocyamine, 4 parts of gelatinized starch solution with the concentration of 40% and 16 parts of gelatinized hydroxypropyl methyl cellulose solution with the concentration of 10% in a mixer for uniform mixing, extruding the mixture into granules by a swing granulator, adding the granules into a spheronizer to form spherical granules, carrying out swing finishing on the spherical granules by a 40-mesh screen, carrying out grading screening, and putting the spherical granules into a fluidized drier to obtain pill cores, wherein the starch and the hydroxypropyl methyl cellulose respectively account for 0.4% of the mass of the pill cores;
in this embodiment, the parameters in the dryer are: the air inlet speed is 80 ℃, the air outlet speed is 73 ℃, and the drying time is 25 minutes;
(3) primary coating
Putting 420 parts of the pellet cores obtained in the step into a particle coating machine, primarily coating 71.5 parts of ethyl cellulose alcohol solution with the concentration of 20 percent as a coating material, and coating the pellet cores through a bottom spraying system of the coating machine until all the coating is finished;
wherein the parameters of the particle coating machine are as follows: the air inlet temperature is 84.9 ℃, the material temperature is 75 ℃, the atomization pressure is 0.80 MPa,the pump flow rate is 20 L.h-1The treatment time is 35 minutes; after coating, carrying out swing granulation and grading screening by a 30-mesh screen to obtain primary coated pellet cores;
(4) secondary coating
Placing the screened primary coated pellet core particles in a fluidized bed coating machine, melting 160 parts of food-grade hydrogenated vegetable oil as a coating material, and carrying out secondary coating on the primary coated pellet core by a bottom spraying system of the fluidized bed coating machine;
wherein, the parameters of the fluidized bed coating machine are as follows: the air inlet temperature is 65 ℃, the material temperature is 43 ℃, the atomization pressure is 0.25 MPa, and the pump flow rate is 30 L.h-1The treatment time is 45 minutes; after the secondary coating is finished, performing swing finishing and grading screening by using a 40-mesh screen to obtain secondary coated guanidinoacetic acid with the mesh size of more than 40.
The starch in this embodiment is any plant-based starch, preferably corn starch or potato starch. Example 1 the final product obtained is in the form of strip, and the active ingredient of glycocyamine after secondary coating can reach 67.8%.
Examples 8 to 11A method for preparing coated guanidinoacetic acid
Examples 8 to 11 are each a method for producing coated guanidinoacetic acid, which is used for producing guanidinoacetic acid as described in any of examples 1 to 6, and which is carried out in the same manner as in example 7, except that: the technical parameters in the preparation process of the coated glycocyamine are different, and the specific parameters are shown in the following table II.
TABLE II technical parameters in the preparation of examples 8 to 11
In this example, the effective component of the secondarily coated guanidinoacetic acid finally obtained in example 7 can be as high as 67.8%. Example 8 the final secondary coated guanidinoacetic acid has an effective component as high as 78.7%. Example 9 the final secondary coated guanidinoacetic acid has an effective component as high as 86.8%. The effective component of the guanidinoacetic acid after secondary coating finally obtained in the embodiment 10 can reach 89.6 percent. The effective component of the glycocyamine after secondary coating finally obtained in the example 11 can reach 74.6 percent.
Example 12 comparative experiment
In the test, a control group adopts non-coated glycocyamine as a feed additive to feed beef cattle, and the beef cattle in the test group adopt coated glycocyamine with 70 percent of effective component as the feed of the feed additive, and the influence on the production performance of the beef cattle is shown in table three after 60 days of feeding.
Influence of surface-coated glycocyamine on beef cattle production performance
Note: the difference between the lower case letters marked on the shoulder of the same line indicates significant difference (P < 0.05).
In the test, the production performance of the beef cattle can be improved by adding the non-coated guanidinoacetic acid and the coated guanidinoacetic acid into the feed, the weight of the beef cattle is increased after the beef cattle is fed for 60 days, but the Average Daily Gain (ADG) of the beef cattle in each test group is higher than that of a control group, the average daily feed intake (DMI) is higher than that of the control group, the feed-meat ratio (F/G) is lower than that of the control group, and the best effect is obtained when the addition amount of the coated guanidinoacetic acid is 0.08% according to the results of the third aspect of the invention.
The test shows that after the glycocyamine is coated, the quality of beef cattle can be improved, the using amount of the glycocyamine is reduced, the using effect of the glycocyamine is improved, and the feed cost is saved.
Claims (9)
1. A preparation method of coated guanidinoacetic acid is characterized in that: the preparation steps are as follows:
(1) pretreatment of
Carrying out superfine grinding and screening on the guanidinoacetic acid to obtain guanidinoacetic acid powder;
(2) preparation of pellet core
Placing guanidinoacetic acid powder and gelatinized starch solution into hydroxypropyl methyl cellulose solution, uniformly mixing, then preparing into spherical particles, screening the spherical particles, and then putting into a dryer for drying to obtain pill cores;
(3) primary coating
Putting the pellet cores into a particle coating machine, primarily coating by adopting a bottom spraying mode and ethyl cellulose alcohol solution or polyacrylic resin IV alcohol solution as a coating material to obtain primarily coated pellet cores, and screening the primarily coated pellet cores;
(4) secondary coating
Placing the screened primary coated pellet core particles in a fluidized bed coating machine, melting the food-grade hydrogenated vegetable oil through a bottom spraying system of the fluidized bed coating machine, and then using the melted food-grade hydrogenated vegetable oil as a coating material to carry out secondary coating on the primary coated pellet core, thereby obtaining the coated glycocyamine.
2. The preparation method of coated guanidinoacetic acid according to claim 1, characterized in that: selecting guanidinoacetic acid powder from the guanidinoacetic acid in the step (1); and carrying out swing arrangement and grading screening on the glycocyamine through a sieve of 80 meshes, and taking glycocyamine powder of 80 meshes.
3. The preparation method of coated glycocyamine according to claim 1, wherein the starch in step (2) is any plant starch, preferably corn starch or potato starch, and the starch accounts for 0.4% ~ 0.6.6% of the mass of the pellet core.
4. The preparation method of the coated guanidinoacetic acid as claimed in claim 1, characterized in that in the step (2), the hydroxypropyl methylcellulose accounts for 0.4 percent ~ 0.6.6 percent, preferably 0.4 percent of the mass of the pellet core;
the concentration of the hydroxypropyl methylcellulose solution is 10% ~ 15%, preferably 10%.
5. The preparation method of coated guanidinoacetic acid as claimed in claim 1, characterized in that the spherical particles formed in step (2) are subjected to swing finishing and classified screening by a 20-mesh ~ 60-mesh screen;
the parameters in the dryer in the step (2) are that the air inlet speed is 80 ~ 85 ℃, the air outlet speed is 60 ~ 80 ℃, and the drying time is 15 ~ 30 minutes.
6. The preparation method of the coated guanidinoacetic acid as claimed in claim 1, wherein the adding mass ratio of the pellet core and the ethyl cellulose or polyacrylic resin IV in the step (3) is 21.5 ~ 28: 1;
the concentration of the ethyl cellulose alcohol solution is 20% ~ 40%, preferably 20%, and the concentration of the polyacrylic resin IV alcohol solution is 5% ~ 8%, preferably 5%;
the parameters of the particle coating machine are that the air inlet temperature is less than 85 ℃, the material temperature is less than 80 ℃, the atomization pressure is 0.80 MPa ~ 0.90.90 MPa, and the pump flow rate is 15 ~ 30 L.h-1Treatment time of 30 ~ 45 minutes;
in the step (3), the primarily coated pellet cores are subjected to swinging, granulating and grading screening by a sieve with 20 meshes and ~ 60 meshes.
7. The preparation method of coated guanidinoacetic acid as claimed in claim 1, wherein the melting temperature of the food grade hydrogenated vegetable oil in the step (4) is 65 ℃ ~ 100 ℃;
the addition mass ratio of the sieved primary coating pellet core particles to the food-grade hydrogenated vegetable oil is 2.5 ~ 12.5.5: 1;
the parameters of the fluidized bed coating machine are that the air inlet temperature is less than 65 ℃, the material temperature is less than 45 ℃, the atomization pressure is 0.20 MPa ~ 0.25.25 MPa, and the pump flow rate is 15 ~ 30 L.h-1The treatment time was 30 ~ 45 minutes.
8. The preparation method of coated guanidinoacetic acid according to claim 1, characterized in that: after the secondary coating in the step (4) is finished, performing swing finishing and grading screening by using a 40-mesh screen, and taking oversize products to obtain coated guanidinoacetic acid.
9. The preparation method of coated guanidinoacetic acid as claimed in claims 1-8, characterized in that the final product has round or oval appearance and the effective component content of guanidinoacetic acid after secondary coating is up to 60% ~ 90%.
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| CN201910984268.6A CN110663821A (en) | 2019-10-16 | 2019-10-16 | Preparation method of coated guanidinoacetic acid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113016939A (en) * | 2021-03-24 | 2021-06-25 | 江西农业大学 | Application of glycocyamine in improving beef cattle production performance, slaughter performance and meat quality |
| CN113367238A (en) * | 2021-06-29 | 2021-09-10 | 固安君德同创生物工程有限公司 | Feed additive for ruminants and preparation method thereof |
| WO2024165344A1 (en) | 2023-02-06 | 2024-08-15 | Evonik Operations Gmbh | Process for producing free-flowing particles comprising or consisting of an n-guanylamino acid |
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| CN104970228A (en) * | 2015-06-16 | 2015-10-14 | 浙江万方生物科技有限公司 | Preparation method for rumen-protected lysine |
| WO2019063669A1 (en) * | 2017-09-28 | 2019-04-04 | Evonik Degussa Gmbh | Rumen protected products |
| CN110214869A (en) * | 2019-07-03 | 2019-09-10 | 四川农业大学 | A kind of compound additive and preparation method promoting the development of Testis of Boar Pig cell Proliferation |
| WO2019185408A1 (en) * | 2018-03-27 | 2019-10-03 | Evonik Degussa Gmbh | Use of guanidinoacetic acid and/or creatine in aquaculture |
-
2019
- 2019-10-16 CN CN201910984268.6A patent/CN110663821A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104970228A (en) * | 2015-06-16 | 2015-10-14 | 浙江万方生物科技有限公司 | Preparation method for rumen-protected lysine |
| WO2019063669A1 (en) * | 2017-09-28 | 2019-04-04 | Evonik Degussa Gmbh | Rumen protected products |
| WO2019185408A1 (en) * | 2018-03-27 | 2019-10-03 | Evonik Degussa Gmbh | Use of guanidinoacetic acid and/or creatine in aquaculture |
| CN110214869A (en) * | 2019-07-03 | 2019-09-10 | 四川农业大学 | A kind of compound additive and preparation method promoting the development of Testis of Boar Pig cell Proliferation |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113016939A (en) * | 2021-03-24 | 2021-06-25 | 江西农业大学 | Application of glycocyamine in improving beef cattle production performance, slaughter performance and meat quality |
| CN113367238A (en) * | 2021-06-29 | 2021-09-10 | 固安君德同创生物工程有限公司 | Feed additive for ruminants and preparation method thereof |
| WO2024165344A1 (en) | 2023-02-06 | 2024-08-15 | Evonik Operations Gmbh | Process for producing free-flowing particles comprising or consisting of an n-guanylamino acid |
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