CN110639028B

CN110639028B - Intestinal tract developer and preparation method thereof

Info

Publication number: CN110639028B
Application number: CN201911076270.XA
Authority: CN
Inventors: 姜从桥; 王东升; 宋国磊; 杜军; 王安锋; 赵迎春
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-06
Filing date: 2019-11-06
Publication date: 2022-07-15
Anticipated expiration: 2039-11-06
Also published as: CN110639028A

Abstract

The invention provides an intestinal tract developer and a preparation method thereof, which encapsulates a countable marker (barium ring, barium bead, barium bar and the like) and a large amount of barium-containing particles in a capsule or mixes the countable marker and the barium-containing particles and then swallows the mixture in the form of powder for a patient. The contrast agent first passes through the oral cavity, then enters the small intestine along the digestive tract, is thoroughly mixed with the food in the small intestine, and then enters the large intestine along with the intestinal contents. The doctor shoots the flat piece of belly X line for the patient at different periods, through observing the development of a large amount of barium-containing particle thing, clearly observes patient's intestines pipe trend, and then accurately judges the position in intestines that the marker is located, knows the marker through stomach intestine transportation time to through its dwell time and number in each intestines section in a certain time to and the discharge rate of marker guides slow transmission patient's typing and degree. In addition, by observing the trend of the intestinal canal, the auxiliary doctor judges whether the patient has a slow colon transmission phenomenon caused by factors such as long colon, compensatory dilatation and the like, so that the doctor can conveniently make further diagnosis and treatment.

Description

Intestinal tract developer and preparation method thereof

Technical Field

The invention relates to the technical field of medical developers, in particular to an intestinal tract developer and a preparation method thereof.

Background

In the clinical diagnosis of chronic constipation, colon transmission tests are usually required for slow transit constipation, and common visualization products are opaque metal pellets, barium rings or barium bars. Because the developing product is opaque, after the developing product enters the intestinal tract, the developing product can be observed after X-ray development, the number of the opaque pellets in different quadrants is calculated, the percentage of the pellets in the possible intestinal tract is estimated, and whether the colon slow transmission phenomenon exists in the possible intestinal tract or not is presumed. The position of the intestinal canal can be changed due to the redundant intestinal canal, so that the positioning difficulty is very easy to cause and misdiagnosis is caused; in addition, the judgment of the intestinal canal is not accurate only through the quadrant where the small ball is located.

Therefore, doctors have used small doses of barium to diagnose patients, but the small doses of barium have the disadvantage that after entering the colon, the barium is easy to absorb water by the colon, so that the barium is stuck on the wall of the colon and cannot move, and at the moment, the problem of intestinal canal transmission or the adhesion of the barium cannot be judged.

Disclosure of Invention

The invention aims to provide an intestinal tract developer and a preparation method thereof, and aims to solve the problems of low diagnosis accuracy and low diagnosis efficiency of the existing developer.

In order to realize the purpose, the invention is realized by the following technical scheme:

an intestinal tract developer comprises barium-containing particles, capsule shell and barium powder; the barium-containing particles and the barium powder are arranged in the hollow cavity of the capsule shell.

An intestinal tract developer comprises barium-containing particles, capsule shells and developing filaments; the barium-containing particles and the developing filaments are arranged in the hollow cavity of the capsule shell.

An intestinal tract developer, comprising barium-containing particles and a capsule shell; the barium-containing particles comprise barium beads and disintegratable barium rings; the barium bead and the disintegratable barium ring are arranged in the hollow cavity of the capsule shell.

An intestinal tract developer comprises barium spheres in spherical shell shape; the shell of the barium ball is provided with an opening; the interior of the barium ball is provided with a disintegratable barium ring.

Optionally, the visualization filament is a barium-containing filament.

Optionally, the developable filament is a blend of a developable substance and a polymeric material.

Optionally, the barium-containing particles are barium beads, barium rings, barium bars; the surface of the barium bead is provided with a plurality of holes, and barium powder is filled in the holes.

Optionally, a capsule shell is tightly wrapped outside the barium beads, and the barium bead capsule is formed by plugging the holes.

Optionally, the barium-containing particles are spheroids, rings or bars with a particle size of 5 mm; the barium powder is barium-containing particles with the particle size less than 10 meshes.

Optionally, the capsule is a gastric or enteric capsule.

A preparation method of a colon transfer experiment developer comprises the following steps:

s1, mixing 10-50 parts of barium sulfate, 50-89 parts of excipient and 0-1 part of processing aid uniformly by a high-speed mixer or an open mill;

s2, making the material subjected to the step S1 into related products through a screw extruder, an injection molding machine or a plate pressing machine and other equipment, and obtaining barium-containing particles with different shapes and sizes.

S3, filling barium-containing particles into the cavity of the capsule shell; or mixing barium-containing particles with barium powder or developing filament respectively, and encapsulating.

Compared with the prior art, the invention has the following beneficial effects:

1. after a patient swallows the marker capsule (gastric soluble), the marker capsule enters the digestive tract through the oral cavity, and the barium-containing particles and barium powder are released after the capsule shell is cracked; the abdomen X-ray plain film is shot for the patient by a doctor at different time intervals, and the time of the developing substances passing through the stomach and small intestine of the patient is observed to assist in judging the dynamic conditions of the stomach and the small intestine.

2. After a patient swallows the marker capsule (enteric coated capsule), the capsule passes through the oral cavity and reaches the small intestine along the digestive tract, and barium-containing particles and barium powder are released, the texture of the capsule is similar to that of intestinal contents, and the propelling process of the contents in the intestine can be simulated to the maximum extent; the motion condition of the marker is observed by observing the abdominal X-ray plain film shot for the patient by the doctor at different time intervals so as to diagnose the colorectal dynamic condition of the patient.

3. The invention displays the trend of the intestinal canal of the patient by observing the distribution form of a large amount of barium powder in the intestinal canal and the advancing condition of the barium powder along with the contents, can assist in observing the anatomical structure of the intestinal canal of the patient, accurately judges the intestinal section where the marker is positioned, further determines the number of the markers in each quadrant, and improves the accuracy of data statistics of the markers.

4. The invention can accurately judge which intestinal tubes have slow transmission phenomenon and the degree thereof according to the quantity of the markers in different intestinal tubes at different time periods; and judging whether the constipation of the patient belongs to the same category according to the discharge rate of the marker within a certain time, thereby improving the diagnosis efficiency.

5. The barium-containing particles of the invention can contain ring-shaped (double-chamber and three-chamber), long-strip-shaped, square-shaped, special-shaped and other structures, and can avoid counting errors when the spheres are completely overlapped in the intestines.

Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a structure of barium beads wrapped in a capsule shell according to another embodiment of the present invention;

FIG. 3 is a schematic diagram of a barium bead structure according to another embodiment of the present invention;

FIG. 4 is a schematic structural diagram in another embodiment of the present invention;

FIG. 5 is a schematic structural diagram of another embodiment of the present invention;

FIG. 6 is a schematic representation of a disintegratable barium ring structure in another embodiment of the present invention;

FIG. 7 is a schematic structural diagram of another embodiment of the present invention;

the reference numbers in the figures illustrate:

1. barium beads; 2. a capsule shell; 3. barium powder; 4. developing the filaments; 5. a hole; 6. a disintegrable barium ring; 7. barium spheres; 8. and (6) opening holes.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention will be further described with reference to the accompanying drawings 1 to 3:

an intestinal tract developer comprises barium beads 1, a capsule shell 2 and barium powder 3; the barium beads 1 and the barium powder 3 are arranged in the hollow cavity of the capsule shell 2.

Preferably, the capsule shell 2 is a dissolvable hollow shell-like structure.

Preferably, the barium-containing particles are of an annular structure with the outer diameter of 5mm and the inner diameter of 3 mm; the barium powder 3 is a barium-containing substance with the particle size of less than 60 meshes.

Preferably, the barium beads 1 are cylinders with a diameter of 3mm and a length of 8 mm; the barium powder 3 is a barium-containing fine particle having a diameter of about 100 mesh.

Preferably, 20 or 24 barium-containing particles 1 are encapsulated within the hollow cavity of the capsule shell 2.

Preferably, barium-containing microparticles of 60-100 mesh diameter are encapsulated within the hollow cavity of the capsule shell 2.

Preferably, 24 ring-shaped barium-containing particles with the outer diameter of 5mm and the inner diameter of 3mm and barium powder with the diameter of about 60 meshes are mixed in the capsule shell.

According to the invention, a plurality of barium-containing particles 1 and barium powder 3 are respectively packaged in the capsule shell 2, after a patient takes the barium-containing particles and the barium powder simultaneously or separately, the capsule firstly passes through the oral cavity and then reaches the small intestine along the digestive tract, and the markers 1 and the barium powder 3 are released and are transmitted in the intestine along with the contents. The doctor can take the abdominal X-ray plain film for the patient at different time periods, and can observe the direction of the intestinal canal of the patient, the number of the markers in each quadrant and the discharge number and time of the markers under the synergistic action of the barium powder and the markers. The doctor is instructed to make a valuable judgment on the constipation condition of the patient. The invention comprises a capsule shell, barium-containing particles and barium powder; the barium-containing particles are barium beads, barium rings, barium bars or special barium-containing substances, wherein the barium-containing particles and barium powder can be mixed in the capsule shell or can be respectively packaged in the capsule shell; the barium beads (barium rings or barium bars) and the barium powder are developing substances, the manufacturing methods are approximately the same, and the density and the shape of the barium beads can be prepared according to the needs; it should be noted that the trend of the intestinal tract of the patient is displayed by observing the distribution form of a large amount of barium powder in the intestinal tract and the advancing condition of the barium powder along with the contents, the anatomical structure of the intestinal tract of the patient can be observed in an auxiliary manner, the intestinal segment where the marker is located can be accurately judged, the number of the markers in each quadrant can be further determined, and the accuracy of data statistics of the markers can be improved.

The preparation method comprises the following steps:

1. vulcanization crosslinking method

Taking 45-90 parts of dihydroxy polydimethylsiloxane as raw rubber, mixing 10-50 parts of barium sulfate, adding a proper amount of vulcanizing agent to prepare 100 parts, uniformly mixing, pressing and molding in a mold, and vulcanizing at high temperature to obtain the product.

2. Radiation cross-linking method

Taking 45-90 parts of methyl vinyl silicone crude rubber, 5-10 parts of methyl silicone oil and 0-50 parts of barium sulfate, preparing 100 parts of the raw rubber, mixing uniformly, then putting the mixture into a mold, and performing radiation crosslinking molding to obtain the product.

3. Physical blending method

Mixing 10-50 parts of barium sulfate or modified barium sulfate and 49-89 parts of resin raw materials (such as non-degradable resins such as PE, PP, PVC and the like, polylactide and copolymers thereof, degradable resins such as polycaprolactone and the like, absorbable materials such as polyethylene glycol and the like) by a high-speed mixer, extruding strips by a double-screw extruder, and cutting into granules. And taking part of the granules, and performing injection molding on the granules by using an injection molding machine to obtain a product with a required shape, wherein the product is used as barium-containing particles capable of being accurately counted. And crushing another part of the granules into irregular particles by a crusher, and sieving the irregular particles by a sieving machine to obtain barium-containing particles with a certain particle size (such as 50-60 meshes) as barium powder for indicating the trend of the intestinal canal.

It should be noted that, the

preparation methods

1, 2 and 3 can all obtain products with different densities by changing the formula, and can also obtain barium-containing particles with different structures by adjusting the structure of the mold.

The contrast agent first passes through the oral cavity, then enters the small intestine along the digestive tract, is thoroughly mixed with the food in the small intestine, and then enters the large intestine along with the intestinal contents. The doctor shoots the abdominal X-ray plain film for the patient at different periods, clearly observes patient's intestines tube trend through observing the development of a large amount of barium powder, and then accurately judges the position in the intestines that marker was located. Therefore, the gastrointestinal transport time of the marker can be known, and the typing and the degree of the slow-delivery patient can be guided by the residence time and the number of the marker in each intestinal segment in a certain time and the discharge rate of the marker. In addition, by observing the trend of the intestinal canal, a doctor is assisted to judge whether the slow colon transmission phenomenon is caused by anatomical factors such as long colon, compensatory dilatation and the like, so that the doctor is guided to further diagnose and treat. With reference to fig. 2 and fig. 3, in another embodiment, different from the above embodiment, the surface of the barium bead 1 has a plurality of holes 5, barium powder 3 is filled in the holes 5, and the capsule shell 2 is tightly wrapped outside the holes 5 of the barium bead 1, so as to realize the plugging of the spheroid, the ring body or the bar body 3.

A plurality of holes 5 for accommodating barium powder 3 are uniformly distributed on the periphery of the barium bead 1.

The barium beads 1 are bead-shaped structures with the diameter of 1-10 mm.

Preferably, the barium bead 1 is prepared by taking 40% of modified barium sulfate and 60% of polyethylene, uniformly mixing, extruding and granulating by a screw extruder, and injection molding the granules by an injection molding machine to obtain the barium bead 1.

In the embodiment, the capsule shells 2 are used for sealing the holes 5, so that after a patient swallows a proper amount of barium bead capsules (about 20 barium bead capsules), the capsule shells 2 on the surfaces of the barium beads 1 are completely cracked and absorbed in the small intestine, and the barium beads 1 release the barium powder 3 in the holes 5 in the transmission process, so that the transmission track of food can be simulated. The doctor shoots the abdominal X-ray plain film for the patient at different periods, knows its place quadrant through observing barium pearl position, and the intestines that barium pearl place can be confirmed to the water shadow appearance background that barium powder 3 formed again. According to the number of barium beads in different intestinal canals in different time periods, which intestinal canals have the slow transmission phenomenon can be accurately judged so as to guide doctors to further diagnose and treat.

Preferably, the barium beads and the barium-containing particles are produced by the same process but in different molds.

With reference to fig. 4, in another embodiment, different from the above embodiment, comprises barium beads 1, capsule shells 2 and developing filaments 4; the barium beads 1 and the developing filaments 4 are arranged in the hollow cavity of the capsule shell 2.

The developing filaments 4 may be classified into three types: the first type is barium wool, i.e., medical cotton wool impregnated with barium sulfate powder. The second type is developable polymer filament (non-degradable) formed by mixing barium sulfate with non-degradable polymer material (PP, PE, silicone rubber). Mixing 10-50 parts of barium sulfate powder with 50-90 parts of medical-grade PE, PP, PVC and other general plastics, adding a small amount of processing aid, mixing by a high-speed mixer, extruding by a screw extruder, bracing, and granulating. The particles are extruded and drawn by a torque rheometer or a special spinning machine. Obtaining the long thread-shaped product after reaching a certain fineness. The third type is developable polymer filament (degradable or absorbable) formed by mixing barium sulfate with degradable or absorbable polymer material. Taking 10-50 parts of barium sulfate powder, mixing with 50-90 parts of degradable materials (such as polylactide, polylactide and copolymers thereof, polyglycolide-trimethylene carbonate copolymer, polyanhydride and the like) or absorbable materials (such as polyvinyl alcohol, polyethylene glycol and the like), adding a proper amount of processing aids, mixing by a high-speed mixer, extruding by a screw extruder, bracing, and granulating. The particles are extruded and drawn by a torque rheometer or a special spinning machine. Obtaining the long-thread product after reaching a certain fineness.

Wherein barium beads 1 and barium wadding 4 are mixed inside the capsule shell 2. After the barium capsule is swallowed by a patient, the barium capsule firstly passes through the oral cavity and then enters the digestive tract, after the capsule shell is digested and absorbed in the digestive tract, the developing substance in the capsule shell is fully mixed with the food, and then the developing substance enters the large intestine along with intestinal contents. The doctor shoots the abdominal X-ray plain film for the patient at different periods, knows the quadrant of the barium bead through observing the position of the barium bead, knows the trend of the intestinal canal through the developing filament, and determines the intestinal canal where the barium bead is located. According to the number of barium beads in different intestinal tubes in different time periods, which intestinal tubes have a slow transmission phenomenon can be accurately judged so as to guide doctors to further diagnose and treat.

The preparation method of the barium bead (or barium ring) is the same as the above.

In another embodiment, in conjunction with fig. 5 and 6, an intestinal tract developer includes barium spheres 7 in the form of spherical shells; the shell of the barium ball 7 is provided with an opening 8; the barium ball 7 is internally provided with a disintegratable barium ring 6.

The size of the disintegratable barium rings 6 is larger than the size of the open pores 8, so that the disintegratable barium rings 6 are not released before the closing of the pores.

The barium ball 7 is internally provided with a plurality of disintegratable barium rings 6 with different disintegration rates.

After the barium ball 7 is swallowed by a patient, the barium ball 7 firstly passes through the oral cavity and then reaches the small intestine along the digestive tract, at the moment, the barium ring starts to slowly disintegrate out barium-containing particles and then is released to the intestinal tract, and the disintegration rate of the disintegratable barium ring 6 is fast or slow, so that the spheroid, the ring body or the strip body can simulate the whole transmission track of food in the intestinal tract. The doctor is at different periods for the patient takes the abdominal X line plain film, because barium ball 7 density is higher, bulky, and its place quadrant is known to 7 positions of accessible observation barium balls, and the intestines pipe that 7 places in barium balls can be confirmed to the transmission orbit that rethread contains the barium particle. According to the quantity of the barium balls 7 in different intestinal canals in different time periods, which intestinal canals have the slow transmission phenomenon can be accurately judged.

In another embodiment, in conjunction with fig. 7, an enteric contrast medium comprises barium beads 1, capsule shells 2 and disintegrable barium rings 6; the barium beads 1 and the disintegratable barium rings 6 are arranged in the hollow cavity of the capsule shell 2.

The disintegrable barium ring 6 has a ring-shaped structure.

The disintegrable barium ring 6 is prepared by taking a proper amount of barium sulfate powder, pregelatinized starch, sodium carboxymethyl cellulose, PEG3350 and silicon dioxide powder, premixing the barium sulfate powder, the pregelatinized starch, the sodium carboxymethyl cellulose, the PEG3350 and the silicon dioxide powder according to a certain proportion, pressing the mixture on a tablet press by using a special die to form a ring, and demoulding.

One specific mixing ratio is as follows:

the preparation process comprises the following steps: 271.25g of sulfuric acid spheroids, annular bodies or strip bodies, 35g of pregelatinized starch, 21g of sodium carboxymethylcellulose, 17.5g of PEG3350, 3.5g of silicon dioxide powder and 1.75g of essence are uniformly mixed, the mixture is filled on a die of an annular groove on a tablet press and pressed into rings to prepare 1000 tablets, and then a special acrylic resin coating layer is coated and dried; the disintegration test showed that the disintegration time of the disintegratable barium ring 6 was 58.26 seconds.

One specific mixing ratio is as follows:

the preparation process comprises the following steps: 271.25g of sulphuric acid spheroids, annular bodies or strip bodies, 35g of pregelatinized starch, 17.5g of sodium carboxymethylcellulose, 21g of PEG3350, 3.5g of silicon dioxide powder and 1.75g of essence are uniformly mixed, the mixture is filled on a mould of an annular groove on a tablet press and pressed into rings to prepare 1000 tablets, and then a specially-made acrylic resin coating layer is coated and dried; the disintegration test showed that the disintegration time of the disintegratable barium ring 6 was 56.42 seconds.

After a patient swallows the barium ball, the barium ball firstly passes through the oral cavity and then enters the alimentary canal, and at the moment, the barium ring begins to slowly disintegrate into a plurality of barium-containing particles with smaller particle sizes and then is released to the intestinal tract. The doctor shoots the abdominal X-ray plain film for the patient at different periods, and because the barium ball is high in density and large in size, the quadrant where the barium ball is located can be known by observing the position of the barium ball, and then the intestinal canal where the barium ball is located can be determined through the barium-containing particles around the barium ball. The number of barium balls in different intestinal canals at different time periods can be used for accurately judging which intestinal canals have a slow transmission phenomenon so as to guide doctors to make further diagnosis and treatment; it should be noted that the barium-containing particles of the present invention may have a ring (double chamber and triple chamber), strip, square, or irregular shape, and the counting error of the balls when they are completely overlapped in the intestine can be avoided.

Preferably, the capsule shell is an enteric capsule shell; can be dissolved in intestinal tract, and will not be dissolved in stomach. The enteric-coated tablet capsule for treating the colonic ulcer is prepared by absorbing the medicine after the medicine is absorbed in the intestinal tract, so that the damage of gastric acid can be avoided, and the accuracy of diagnosis is ensured.

When the invention is used by the structure in the embodiment, a patient swallows the marker capsule (gastric soluble), enters the digestive tract through the oral cavity, and the capsule shell is cracked to release barium-containing particles and barium powder; the abdomen X-ray plain film is shot for a patient by a doctor at different time intervals, and the time of developing substances passing through the stomach and small intestine of the patient is observed to assist in judging the power condition of the stomach and small intestine; after a patient swallows the marker capsule (enteric coating), the capsule passes through the oral cavity and reaches the small intestine along the digestive tract, and barium-containing particles and barium powder are released, the texture of the barium-containing particles and barium powder is similar to that of intestinal contents, and the propelling process of the contents in the intestine can be simulated to the maximum extent; observing the motion condition of the marker by observing the abdominal X-ray plain film shot by the doctor for the patient at different time intervals so as to diagnose the colorectal dynamic condition of the patient; the invention has simple and novel structure, convenient production and manufacture and low cost, can accurately judge the intestinal canal with slow transmission phenomenon by using the developer, judges the constipation of a patient according to the discharge rate of the marker within a certain time, greatly improves the diagnosis efficiency and is worthy of clinical popularization.

It is to be understood that the detailed description of the invention is not given to the details of the prior art, and that the invention is not limited to the details of the prior art, and that the invention can be implemented by those skilled in the art without inventive step, and that the specific connection method has a wide range of applications in daily life in the field, and will not be described in detail herein.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, but are not intended to indicate or imply that the device or element so referred to must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be construed as limiting the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be interconnected within two elements or in a relationship where two elements interact with each other unless otherwise specifically limited. The specific meanings of the above terms in the present invention can be understood according to specific situations by those of ordinary skill in the art.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

In the description of the specification, reference to the description of "one embodiment," "some embodiments," "an example," "a specific example," or "some examples" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Moreover, various embodiments or examples and features of various embodiments or examples described in this specification can be combined and combined by one skilled in the art without being mutually inconsistent.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.

Claims

1. An intestinal tract developer, characterized in that: comprises barium-containing particles, capsule shells (2) and developing filaments (4); the barium-containing particles and the developing filaments (4) are arranged in a hollow cavity of the capsule shell (2); the barium-containing particles are barium beads (1); the surface of the barium bead (1) is provided with a plurality of holes (5), and the holes (5) are filled with barium powder (3).

2. The intestinal tract developer according to claim 1, wherein: the developing filaments (4) are barium floc.

3. The intestinal tract developer according to claim 2, wherein: the developing silk-shaped object (4) is a mixture of an X-ray-impermeable substance and a degradable or non-degradable high polymer material.

4. The intestinal tract developer according to claim 1, wherein: the capsule shell (2) is tightly wrapped outside the barium bead (1), and the barium bead capsule is formed by plugging the hole (5).

5. An intestinal tract developer according to any one of claims 1 to 3, characterized in that: the barium-containing particles are spheroids with the particle size of 5 mm; the barium powder (3) is a discrete particle aggregate with the particle size smaller than 10 meshes.

6. A process for the preparation of an enteric contrast medium as claimed in any of claims 1 to 3, comprising the steps of:

s2, preparing related products from the materials obtained in the step S1 through a screw extruder, a plate pressing machine or an injection molding machine, and obtaining barium-containing particles with different shapes and sizes;

s3, respectively mixing the barium-containing particles with the developing filaments (4) and filling the mixture into the capsule shell (2).