CN1047094C - Preparing method for label of colonic transportation test - Google Patents
Preparing method for label of colonic transportation test Download PDFInfo
- Publication number
- CN1047094C CN1047094C CN92103751A CN92103751A CN1047094C CN 1047094 C CN1047094 C CN 1047094C CN 92103751 A CN92103751 A CN 92103751A CN 92103751 A CN92103751 A CN 92103751A CN 1047094 C CN1047094 C CN 1047094C
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- gram
- colonic
- preparation
- label
- barium sulfate
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Abstract
The present invention discloses a preparation method for a marker of colonic transportation tests, which belongs to a preparation method for preparations of in vivo tests. The marker has the preparation method that medical silastic, methyl vinyl polyorganosiloxane, methyl phenyl silicone oil, medical barium sulfate, silicon dioxide in a gas phase, and 2, 5 dimethyl-2, 5 di-tert-butyl ethane peroxide are granulated and packed into capsules after orderly charged, compounded, refined and vulcanized in a secondary way. The marker is safe and nontoxic to human bodies, has clear development under X-rays, and can be used for the colonic transportation tests.
Description
The present invention relates to a kind of preparation method of label of colonic transportation test, belong to the preparation method of in vivo test with preparation.
Utilize the barium sulfate insoluble in water, be not absorbed, radiopaque characteristics are done the gastrointestinal imaging medication and are used for many years.Make gastrointestinal series as 40% barium sulfate suspension; 70-80% barium sulfate is stuck with paste and suitablely to be added starch and make gullet radiography; 200-300 gram barium sulfate adds 1000 milliliters of clear water and makes the barium coloclysis; And do bronchography agent or the like with the barium sulfate slurry that contains the tragakanta.
Europe patent 89117464.1 relates to a kind of large intestine X ray examination contrast agent, is the synthetic suspension of barium sulfate and tragacanth gum
United States Patent (USP) 3,021,317th, a kind of being fit to and the blended powder of aqueous medium, constitute radiopaque suspension, be used for esophagus and gastrointestinal X ray examination.This powder comprises barium sulfate and contains the magnesium montorillonite clay.Magnesium trisilicate, Carboxymethyl cellulose sodium, antifoaming agent.
Derwent patent documentation 86-047594/07 has introduced a kind of preparation that is used for the gastroenteropathy radiodiagnosis, mainly contains barium sulfate and auxiliary material siloxane polymer, silicon dioxide, Polyethylene Glycol ether and cellulosic derivant.
Above-mentioned preparation is liquid state or pasty state, and the X line shows that down it is in gastral full situation.
United States Patent (USP) 3,017,329 relate to a kind of intestinal pill of spherical entity, and diameter has nothing in common with each other.Utilize the X line to follow the trail of pill, record is determined the position that intestinal tube is narrow than the halt of bolus, and record is by the size of the maximum pill of intestinal, to measure the narrowness of intestinal.This intestinal pill contains barium sulfate and the plain ether of bonding agent water soluble fiber, and wherein the etherificate base is to be selected from methyl, the common part of forming of ethoxy and hydroxypropyl and mixture thereof.
In the diagnosis of some disease of digestive tract, must understand the intestinal movement function.In screening surgical patient process, colonic transit test is very important, and promptly oral opacity contains the granulated label of barium sulfate, and the X line is observed the intestinal delivery time down.
Purpose of the present invention just provides a kind of preparation method of being convenient to observe the softish label of colonic transportation test of graininess quality of intestinal delivery time, and therefore, the present invention has any different in prior art.
The present invention is nontoxic to human body according to medicinal barium sulfate, and opacity, makes that softish silica gel particle realizes.
In each basic recipe and proportioning thereof of this label, medical grade silicon rubber 100-120 gram, ethylene methacrylic polysiloxanes 2.5-4.0 gram, methyl phenyl silicone oil 3-5 gram, medicinal barium sulfate 50-60 gram, fumed silica 20-40 gram, 2,5 dimethyl-2,5 di-t-butyl peroxide hexane 1.0-1.2 gram, and it is reinforced mixing according to sequencing, treat to go again after sizing material evenly 5-10 refine, sizing material row mat woven of fine bamboo strips secondary extrusion in extruder through the glue pressing machine extrusion, obtain the shaping adhesive tape of diameter 3mm, adhesive tape is through decocting in water sulfuration first time afterwash, the sulfuration for the second time of multiple row, the silica gel strip of making cuts into the granule of 3 * 3mm, the hard capsule of packing into after the sterilization.
The label of colonic transportation test of making like this is off-white color, the quality softness, and high resilience, the easy damaged digestive tract is not with low cost, image definition under the X line.
During use, make the oral hard capsule that contains the opacity label of surgical patient to be screened, can under the X line, observe the time of this label in the intestinal transmission.
Below in conjunction with embodiment prescription of the present invention, proportioning and method for production are described further.
At room temperature take by weighing GY-131 medical grade silicon rubber 2000 gram, contents of ethylene ethylene methacrylic polysiloxanes 50 grams, methyl phenyl silicone oil 60 grams, medicinal barium sulfate 1000 grams, 4 at 10-12 mole %
#Fumed silica 500 grams, 2,5 dimethyl-2,5 di-t-butyl peroxide hexane, 20 grams, mixing at the up sizing material of φ 160 * 320 opening rubber mixing machines in order, after treating that it evenly, carry out sizing material refine five times continuously, mixing and refining time was controlled in 30-45 minute to be finished.On glue pressing machine, take off the sizing material of moulding, in XJ-45B rubber extruded machine, carry out mat woven of fine bamboo strips secondary extrusion and use 1.6 millimeters degree of lip-roundings of φ, speed controlling is at 300-500 rev/min, make the product diameter 3mm of acquisition, the adhesive tape that presses is evenly coiled in container, adopt the sulfuration of the capable decocting in water for the first time of horizontal direct gas vulcanizing tank, temperature is controlled at 148 ℃ ± 2 ℃, and the time is 60 minutes, the adhesive tape clear water that takes out is cleaned, the reuse distilled water flushing is gone mat woven of fine bamboo strips post-cure again, room temperature → 100 ℃ 1 hour, 100 → 150 ℃ 1 hour, 150 → 180 ℃ 1 hour, 180 ℃ of constant temperature 4 hours amounts to 7 hours.The external diameter 3mm silica gel strip that makes cuts into the granule of 3 * 3mm, and per 10 the 1 piece of hard capsules of packing in sterilization back are standby.Being convenient to the patient swallows.
This label toxicology testing result:
The inspection item result
The quick carcinogenic test feminine gender of Ames, no carcinogenesis
Lure the feminine gender that is put to the test
The medullary cell sister chromosome has no adverse effects
Exchange test
The growth of cell culture cell is normal
Muscle embedding (30 days, 60 days, not damaged
90 days, 180 days)
The no abnormal reaction of acute toxicity test does not have dead
The label of colonic transportation test of making as stated above through the research of clinical 70 routine colon transmission tests, has nontoxic: in not cracking of digestive tract, do not absorb, insoluble; In light weight.In chyme or feces, very easily wrapped up in and taken propelling; Under the X line, various build persons can both clearly be developed; The ability autoclave sterilization.
Claims (1)
1. the preparation method of a label of colonic transportation test, it is characterized in that in each basic recipe, medical grade silicon rubber 100-120 gram, ethylene methacrylic polysiloxanes 2.5-4.0 gram, methyl phenyl silicone oil 3-5 gram, medicinal barium sulfate 50-60 gram, fumed silica 20-40 gram, 2,5 dimethyl-2,5 di-t-butyl peroxide hexane 1.0-1.2 gram, and it is reinforced mixing according to sequencing, after treating that sizing material evenly, capable again 5-10 refine, the sizing material row in extruder that extrudes through glue pressing machine pushes for the second time, obtain the shaping adhesive tape of diameter 3mm, adhesive tape is through a decocting in water sulfuration of mat woven of fine bamboo strips afterwash, capable again mat woven of fine bamboo strips post-cure, the silica gel strip of making cuts into the granule of 3 * 3mm, the hard capsule of packing into after the sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92103751A CN1047094C (en) | 1992-05-21 | 1992-05-21 | Preparing method for label of colonic transportation test |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92103751A CN1047094C (en) | 1992-05-21 | 1992-05-21 | Preparing method for label of colonic transportation test |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1078911A CN1078911A (en) | 1993-12-01 |
| CN1047094C true CN1047094C (en) | 1999-12-08 |
Family
ID=4940415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92103751A Expired - Fee Related CN1047094C (en) | 1992-05-21 | 1992-05-21 | Preparing method for label of colonic transportation test |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1047094C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773674B (en) * | 2010-03-29 | 2014-09-24 | 程晓堂 | Gastrointestinal motivity marker capsule |
| CN105848582A (en) * | 2013-08-16 | 2016-08-10 | 加利福尼亚大学董事会 | Silicone-based enteric CT contrast material |
| CN106492234A (en) * | 2016-11-17 | 2017-03-15 | 卢立欣 | A kind of barium agent label of colonic transportation test and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0260266A1 (en) * | 1985-06-18 | 1988-03-23 | Axjo Plastic Ab | Wire or cable reel |
-
1992
- 1992-05-21 CN CN92103751A patent/CN1047094C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0260266A1 (en) * | 1985-06-18 | 1988-03-23 | Axjo Plastic Ab | Wire or cable reel |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1078911A (en) | 1993-12-01 |
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| CF01 | Termination of patent right due to non-payment of annual fee |