CN110638522A - Nano laser probe - Google Patents
Nano laser probe Download PDFInfo
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- CN110638522A CN110638522A CN201910878457.5A CN201910878457A CN110638522A CN 110638522 A CN110638522 A CN 110638522A CN 201910878457 A CN201910878457 A CN 201910878457A CN 110638522 A CN110638522 A CN 110638522A
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- laser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20361—Beam shaping or redirecting; Optical components therefor with redirecting based on sensed condition, e.g. tissue analysis or tissue movement
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- Heart & Thoracic Surgery (AREA)
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- General Health & Medical Sciences (AREA)
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- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
Abstract
The invention discloses a nano laser probe, and relates to the field of medical instruments. The method is used for solving the problem that the cancer cell cannot be definitely targeted in the cancer treatment in the prior art, so that the normal cell is damaged and even the normal cell is cancerated. The nano laser probe includes: the device comprises a laser, a laser coupling system, a flexible transmission optical fiber and a laser shaping and focusing system; the laser coupling system is used for coupling the laser emitted by the laser to obtain coupled laser; the flexible transmission optical fiber is used for transmitting the coupling laser to the laser shaping focusing system; the laser shaping and focusing system is used for focusing the coupling laser to form focused laser, and the focused laser is used for irradiating the probe.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a nanometer laser probe.
Background
Tumor refers to a new organism formed after the cell proliferation caused by the mutation of the intracellular gene of the organism under the action of the carcinogenic factor. Tumors are classified as benign and malignant, and cancer refers to malignant tumor in tumors.
In recent years, the incidence and mortality of Chinese cancers are increasing. Cancer has become the first cause of death in china since 2010, seriously threatening human life and health. In 2015, according to the statistical data of Chinese cancers, 12000 patients with confirmed cancer are newly added on average every day, and about 7500 patients with confirmed cancer die every day. From the data, more and more people suffer from the pain and threat of cancer, because the types of cancer are various, the treatment means which is effective in hospitals at present is limited, and the treatment means such as chemotherapy and radiotherapy are used for killing tumors, so that the disease development is inhibited to a certain extent, but certain side effects such as immunity reduction, bone marrow inhibition and the like exist. Often with serious consequences: the operation causes the patient to lose the organs and functions which can be preserved originally; the high dose of chemotherapy drugs can not reduce the tumor, but cause the patient to be more painful and weakened due to high side effect, and even lose the life prematurely; excessive high dose radiation therapy can cause irreversible damage to normal tissue surrounding the tumor.
In summary, the cancer treatment in the prior art has the problem that the cancer cell cannot be clearly targeted, so that the normal cell is damaged and even becomes cancerous.
Disclosure of Invention
The embodiment of the invention provides a nano laser probe, which is used for solving the problem that in the prior art, cancer cells cannot be definitely targeted for cancer treatment, so that normal cells are damaged and even the normal cells become cancerous.
The embodiment of the invention provides a nanometer laser probe, which comprises: the device comprises a laser, a laser coupling system, a flexible transmission optical fiber and a laser shaping and focusing system;
the laser coupling system is used for coupling the laser emitted by the laser to obtain coupled laser;
the flexible transmission optical fiber is used for transmitting the coupling laser to the laser shaping focusing system;
the laser shaping and focusing system is used for focusing the coupling laser to form focused laser, and the focused laser is used for irradiating the probe.
Preferably, the laser is a near infrared laser;
the laser comprises any one of a solid laser, a semiconductor laser, a gas laser, a fiber laser and a dye laser.
Preferably, the wavelength of the laser is 980 nm-1064 nm;
the laser comprises any one of a solid laser, a semiconductor laser, a gas laser, a fiber laser and a dye laser.
Preferably, the optical fiber core of the flexible transmission optical fiber is any one of 50 micrometers, 100 micrometers, 200 micrometers and 300 micrometers.
Preferably, the probe is one of nano-kinase, nano-antibody, nano-folic acid or nano-water photosensitizer.
Preferably, the laser coupling system is an optical coupling system.
The embodiment of the invention provides a nano laser probe, which comprises: the device comprises a laser, a laser coupling system, a flexible transmission optical fiber and a laser shaping and focusing system; the laser coupling system is used for coupling the laser emitted by the laser to obtain coupled laser; the flexible transmission optical fiber is used for transmitting the coupling laser to the laser shaping focusing system; the laser shaping and focusing system is used for focusing the coupling laser to form focused laser, and the focused laser is used for irradiating the probe. The nanometer laser probe comprises a laser device, wherein laser of the laser device passes through a laser coupling system, a flexible transmission optical fiber and a laser shaping focusing system to form focused laser, and the focused laser can irradiate the probe, so that the aim of accurately determining cancer cells can be realized, and the problem that normal cells are damaged or even normal cells are cancerated in the prior art aiming at cancer treatment can be solved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a nano laser probe according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Fig. 1 schematically illustrates a structural diagram of a nano-laser probe according to an embodiment of the present invention, and as shown in fig. 1, the nano-laser probe mainly includes: a laser 101, a laser coupling system 102, a flexible transmission fiber 103 and a laser shaping focusing system 104.
As shown in fig. 1, the nano-laser probe includes a laser 101 that is an infrared laser 101, which may be a solid laser 101, a semiconductor laser 101, a gas laser 101, a fiber laser 101, or a dye laser 101. In the embodiment of the present invention, the specific type of the laser 101 is not limited at all. Further, the wavelength of the laser 101 may be in the range of 980 nm to 1064 nm.
In the embodiment of the present invention, the laser 101 mainly functions to emit laser light, and further, since the emitting end of the laser 101 is connected to the laser coupling system 102, the laser light from the laser 101 is transmitted to the laser coupling system 102 and passes through the laser coupling system 102 to form coupled laser light, in the embodiment of the present invention, the laser coupling system 102 may be an optical coupling system.
Further, the coupled laser light from the laser coupling system 102 is transmitted to the laser shaping focusing system 104 through the flexible transmission fiber 103. In the embodiment of the present invention, the fiber core diameter of the flexible transmission fiber 103 may be 50 micrometers, may be 100 micrometers, may be 200 micrometers, and may also be 300 micrometers. In the embodiment of the present invention, the diameter of the optical fiber core of the flexible transmission fiber 103 is not particularly limited.
The laser shaping and focusing system 104 is used for focusing the coupled laser transmitted through the flexible transmission fiber 103 to form a focused laser.
In one embodiment of the present invention, the focused laser is used to irradiate the probe 105. in one embodiment, the probe 105 may be a nano-kinase, which can accurately detect the cancer cell when the nano-kinase enters the circulatory system, and the focused laser can irradiate the cancer cell when the focused laser irradiates the probe 105.
In one embodiment, the probe 105 may be a nanobody, which is capable of accurately targeting cancer cells after entering the circulatory system, and may be capable of targeting cancer cells when focused laser light is directed at the probe 105.
In one embodiment, the probe 105 may be nano-folic acid, which can accurately detect cancer cells after entering the circulatory system, and when focused laser light is irradiated on the probe 105, the focused laser light can irradiate on the cancer cells.
In one embodiment, the probe 105 may be a nano-water photosensitizer, which is capable of accurately detecting cancer cells after entering the circulatory system, and is capable of irradiating cancer cells when focused laser light is irradiated on the probe 105.
The embodiment of the invention provides that the laser 101 in the nanometer laser is a solid-state laser 101, the wavelength of the laser is 1064 nanometers, and the laser power is 60 mw; the core diameter of the flexible transmission fiber 103 is 100 micrometers, and the length of the flexible transmission fiber 103 is 1 meter.
In summary, an embodiment of the present invention provides a nano laser probe, including: the device comprises a laser, a laser coupling system, a flexible transmission optical fiber and a laser shaping and focusing system; the laser coupling system is used for coupling the laser emitted by the laser to obtain coupled laser; the flexible transmission optical fiber is used for transmitting the coupling laser to the laser shaping focusing system; the laser shaping and focusing system is used for focusing the coupling laser to form focused laser, and the focused laser is used for irradiating the probe. The nanometer laser probe comprises a laser device, wherein laser of the laser device passes through a laser coupling system, a flexible transmission optical fiber and a laser shaping focusing system to form focused laser, and the focused laser can irradiate the probe, so that the aim of accurately determining cancer cells can be realized, and the problem that normal cells are damaged or even normal cells are cancerated in the prior art aiming at cancer treatment can be solved.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (6)
1. A nanolaser probe, comprising: the device comprises a laser, a laser coupling system, a flexible transmission optical fiber and a laser shaping and focusing system;
the laser coupling system is used for coupling the laser emitted by the laser to obtain coupled laser;
the flexible transmission optical fiber is used for transmitting the coupling laser to the laser shaping focusing system;
the laser shaping and focusing system is used for focusing the coupling laser to form focused laser, and the focused laser is used for irradiating the probe.
2. The nanolaser probe as claimed in claim 1, wherein the laser is a near infrared laser;
the laser comprises any one of a solid laser, a semiconductor laser, a gas laser, a fiber laser and a dye laser.
3. The nanolaser probe as claimed in claim 2, wherein the laser has a wavelength of 980 nm to 1064 nm.
4. The nanolaser probe as claimed in claim 1, wherein the flexible transmission fiber has a fiber core of any one of 50 microns, 100 microns, 200 microns, 300 microns.
5. The nanolaser probe as claimed in claim 1, wherein the probe is one of nanolokinase, nanobody, nanolipoic acid or nanolater photosensitizer.
6. The nanolaser probe as claimed in claim 1, wherein the laser coupling system is an optical coupling system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910878457.5A CN110638522A (en) | 2019-09-17 | 2019-09-17 | Nano laser probe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910878457.5A CN110638522A (en) | 2019-09-17 | 2019-09-17 | Nano laser probe |
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|---|---|
| CN110638522A true CN110638522A (en) | 2020-01-03 |
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| CN201910878457.5A Pending CN110638522A (en) | 2019-09-17 | 2019-09-17 | Nano laser probe |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012114333A1 (en) * | 2011-02-24 | 2012-08-30 | Ilan Ben Oren | Hybrid catheter for vascular intervention |
| CN205144726U (en) * | 2015-09-11 | 2016-04-13 | 西安交通大学第一附属医院 | High -power semiconductor laser device of performing operation |
| CN108175859A (en) * | 2018-02-11 | 2018-06-19 | 中山大学 | A kind of multimode magnetic photo-thermal diagnosis integration nano-probe and its preparation method and application |
| CN108245126A (en) * | 2018-03-26 | 2018-07-06 | 精微视达医疗科技（武汉）有限公司 | It is a kind of can be with the sonde-type co-focusing micro-endoscope of laser ablation |
| CN109172821A (en) * | 2018-06-28 | 2019-01-11 | 上海交通大学 | Calcium carbonate coats nanometer Venus fluorescence probe, preparation method and application |
-
2019
- 2019-09-17 CN CN201910878457.5A patent/CN110638522A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012114333A1 (en) * | 2011-02-24 | 2012-08-30 | Ilan Ben Oren | Hybrid catheter for vascular intervention |
| CN205144726U (en) * | 2015-09-11 | 2016-04-13 | 西安交通大学第一附属医院 | High -power semiconductor laser device of performing operation |
| CN108175859A (en) * | 2018-02-11 | 2018-06-19 | 中山大学 | A kind of multimode magnetic photo-thermal diagnosis integration nano-probe and its preparation method and application |
| CN108245126A (en) * | 2018-03-26 | 2018-07-06 | 精微视达医疗科技（武汉）有限公司 | It is a kind of can be with the sonde-type co-focusing micro-endoscope of laser ablation |
| CN109172821A (en) * | 2018-06-28 | 2019-01-11 | 上海交通大学 | Calcium carbonate coats nanometer Venus fluorescence probe, preparation method and application |
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Application publication date: 20200103 |