CN108245126A - It is a kind of can be with the sonde-type co-focusing micro-endoscope of laser ablation - Google Patents
It is a kind of can be with the sonde-type co-focusing micro-endoscope of laser ablation Download PDFInfo
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- CN108245126A CN108245126A CN201810253901.XA CN201810253901A CN108245126A CN 108245126 A CN108245126 A CN 108245126A CN 201810253901 A CN201810253901 A CN 201810253901A CN 108245126 A CN108245126 A CN 108245126A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
- A61B1/00167—Details of optical fibre bundles, e.g. shape or fibre distribution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
- A61B1/0017—Details of single optical fibres, e.g. material or cladding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/31—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00482—Digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2205—Characteristics of fibres
- A61B2018/2211—Plurality of fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2205—Characteristics of fibres
- A61B2018/2222—Fibre material or composition
Abstract
The invention discloses it is a kind of can be with the sonde-type co-focusing micro-endoscope of laser ablation, there are two types of lasers for tool simultaneously, one kind is optical excited laser, another kind is ablation laser, the ablation laser that the ablation laser is sent out is coupled into coaxial fashion in the light path of the excitation laser, can micro- simultaneously and laser ablation confocal endoscope system with formation.The present invention introduces coaxial optical path in the light path of sonde-type co-focusing micro-endoscope, high energy laser is coupled by confocal endoscope system by dichroscope and hybrid fiber beam, laser ablation treatment is carried out under the auxiliary of the realtime graphic of co-focusing micro-endoscope, to the early lesion tissue made a definite diagnosis in real time, realize the combination of " diagnosis " and " treatment ", malignant disease is prevented, such as the further development of canceration.
Description
Technical field
The invention belongs to endoscopic arts, and in particular to a kind of that burnt microscopy endoscopic can be copolymerized with the sonde-type of laser ablation
Mirror.
Background technology
Micro-endoscope is that one kind can stretch into human body by channels such as gastroscope, Sigmoidoscopes, obtains topographic histology image
To realize the Medical Devices precisely diagnosed of minimal disease, gastrointestinal disease and the change of early stage gastrointestinal cancer.Because with quick, accurate
The features such as true and noninvasive, it may replace traditional endoscopic biopsy and pathological examination in future soon, become as gastrointestinal tract
Disease and early stage gastrointestinal cancer become the main means and equipment of diagnosis.
Micro-endoscope can stretch into human body by instrument cavity, obtain lesion portion under the guiding of micro mirror, Sigmoidoscope etc.
The histology picture of position.By a series of real-time images, 1. veteran doctor can acquire realtime graphic；2. and then root
Accurate diagnosis is made in real time according to the lesion characteristics in image.In general, the function of general micro-endoscope can only help
Doctor obtains the lesion image that auxiliary diagnosis needs, but does not have further treatment structure and function.
Laser ablation treatment melts lesions position, such as lymphatic vessel, cancerous issue orientation by superlaser, makes lesion
Gasify rapidly at position.Because being usually deep into lesions position by optical fiber carries out ablation, therefore can avoid initiative hand
Mechanical damage caused by tissue, organ are pulled, detach etc. in art.Existing laser ablation instrument such as laser ablation needle is at least
There are following defects：
1st, the cooperation of other independent image documentation equipments is generally required, the two matching is inconvenient for use, causes medical equipment is repeated multiple times to invade
Enter human body, increase patient's pain, the two matching is also inaccurate, be easy to cause ablation laser to normal group of lesions position periphery
The damage knitted, causes complication；
2nd, it is popped one's head in by ablation needle internal reservation pipeline for miniature image in the scheme stretched into, miniature image probe needs to account for
With originally limited ablation needle space, particularly ablation needle head position so that otherwise ablation needle volume is excessive, passes through and treats
Organization object be restricted or miniature image probe size is limited, imaging effect is poor, and requirements of type selecting is high, involves great expense.
Invention content
For at least one of prior art disadvantages described above or Improvement requirement, the present invention provides one kind to be disappeared with laser
The sonde-type co-focusing micro-endoscope melted, introduces coaxial optical path in the light path of sonde-type co-focusing micro-endoscope, passes through
High energy laser is coupled into confocal endoscope system by dichroscope and hybrid fiber beam, in the reality of co-focusing micro-endoscope
When image auxiliary under, laser ablation treatment is carried out to the early lesion tissue made a definite diagnosis in real time, realize " diagnosis " and " treatment "
Combination, malignant disease is prevented, such as the further development of canceration.
To achieve the above object, one side according to the invention, provide a kind of can be total to the sonde-type of laser ablation
Micro-endoscope is focused on, including two different lasers, one kind is optical excited laser, and another kind is ablation laser；
Further include the first dichroscope, two-dimentional scanning mechanism, coupling object lens, image-carrying fiber bundle, miniature object lens and photoelectricity
Detector；
The optical excited laser is arranged in the incident direction of first dichroscope, the two-dimentional scanning mechanism setting
On the reflection direction of first dichroscope, the coupling object lens are arranged on the reflection direction of the two-dimentional scanning mechanism
On, one end connection coupling object lens, the other end of the image-carrying fiber bundle connect the miniature object lens, and excitation laser is arranged on
It is focused at the miniature object lens and fluorescence is inspired on the lesions position being colored, the photodetector is arranged on described first
In the fluorescence circuit transmission direction of dichroscope；
The ablation laser is arranged between the two-dimentional scanning mechanism and the coupling object lens, and the ablation sent out swashs
Light is coupled into the image-carrying fiber bundle and the miniature object lens in coaxial fashion, can be micro- simultaneously and laser ablation with formation
Confocal endoscope system.
Preferably, the sonde-type co-focusing micro-endoscope further includes the second dichroscope, which sets
In the transmission direction for putting between the two-dimentional scanning mechanism and the coupling object lens, excitation laser and fluorescence circuit；It is described
Ablation laser is arranged in the incident direction of second dichroscope, incident ablation laser and second dichroscope
Angle be 45 °, it is described coupling object lens be arranged on ablation laser reflection direction on.
Preferably, the sonde-type co-focusing micro-endoscope, which further includes, expands microscope group, relaying microscope group, apeture lens, institute
It states and expands microscope group and be arranged between the optical excited laser and first dichroscope, incident direction of excitation laser；
The relaying microscope group is arranged on the light of between the two-dimentional scanning mechanism and second dichroscope, excitation laser and fluorescence
On the road；The apeture lens be arranged on it is between first dichroscope and the photodetector, on Fluoroscopic direction；
The two-dimentional scanning mechanism is composed using galvanometer type galvanometer and mode of resonance galvanometer.
Preferably, the connection light path of sonde-type co-focusing micro-endoscope is：
The optical excited laser sends out excitation laser, expands as excitation laser beam, is incident on described through the microscope group that expands
First dichroscope, is reflected towards the two-dimentional scanning mechanism, and the two-dimentional scanning mechanism makes excitation laser beam in two-dimensional surface
It is interior into horizontal deflection, deflected light beam by the relaying microscope group, transmitted through second dichroscope, using the coupling
Focal spot corresponding with scanning mode is formed after object lens one by one, these focal spots progressively scan the image-carrying fiber bundle proximal end
End face is simultaneously implanted sequentially in the fibre core of image-carrying fiber bundle, and the excitation laser after being transmitted via the image-carrying fiber bundle is passed as light
The miniature object lens of fine Shu Yuanduan are focused on the lesions position being colored；
The lesions position the being colored fluorescence sent out after laser stimulation that is excited is returned along original optical path, is passed sequentially through described micro-
Type object lens, image-carrying fiber bundle, coupling object lens, the second dichroscope, relaying microscope group, two-dimentional scanning mechanism, the first dichroscope, needle
Hole lens reach on the photodetector, by image mosaic and image enhancement processing algorithm, obtain a series of be colored
The cell grade image of lesions position provides realtime graphic auxiliary for diagnosis；
Meanwhile coaxial optical path is also introduced, the ablation laser sends out high energy ablation laser, is incident to the described 2nd 2
To Look mirror, reflex to the coupling object lens, be coupled into coaxial fashion the image-carrying fiber bundle and miniature object lens composition be total to
Focusing probe, ablation laser focus on the lesions position being colored so that the high-energy of focusing makes pathological tissues quickly inactivate,
Apoptosis, gasification, the cell melted due to gasification, tissue are absorbed by organisms, and so as to make foci disappearance, realize that real time laser ablation is controlled
It treats.
Preferably, two surfaces of second dichroscope are plated with film layer, and the film layer is anti-reflection by the excitation laser
Excitation laser and the lesions position by being colored that device is sent out excite and return the fluorescence of original optical path, and reflect by the ablation
The ablation laser that laser is sent out.
Preferably, the image-carrying fiber bundle is a kind of hybrid fiber beam, and including inside and outside three-decker, internal layer is at center
A piece energy transmission optical fibre, the middle layer outside the energy transmission optical fibre are equipped with tens thousand of single mode optical fibers, and outermost layer is coating
Layer.
Preferably, the diameter of the hybrid fiber beam is between 600 μm~1500 μm；
For the diameter of the energy transmission optical fibre between 25 μm~125 μm, core material is high purity quartz, and clad material is
Fluorine-doped quartz；
For the diameter of the single mode optical fiber between 1~5 μm, core material is high purity quartz；
The dope layer is polymer plastic.
Preferably, the ablation laser of ablation laser outgoing is continuous laser or short-pulse laser；Preferably,
The short-pulse laser that wavelength for gasification is 980nm or the short pulse that the wavelength convenient for penetrating is 808nm, 1064nm swash
Light.
Preferably, the excitation laser that the miniature object lens not only send out the optical excited laser, the also disease to being colored
The fluorescence that stove position excites and returns carries out anaberration, image quality optimization；Preferably, the excitation laser wavelength is 488nm, described
The wavelength of fluorescence is 520nm；
Each minute surface of the miniature object lens carries out including plating antireflective coating, eliminates inside for the corresponding wavelength of ablation laser
The processing of focus point so as to increase the transmission characteristic of ablation laser, avoids the ablation laser of high energy by eyeglass absorption or inside
It focuses on high temperature raising in rear lens and damages the miniature object lens.
Preferably, sonde-type co-focusing micro-endoscope further includes circuit module, connection control the optical excited laser,
Ablation laser and photodetector connect the circuit module including foot-operated ancillary equipment, to be sent to signal, open institute
It states ablation laser and realizes laser ablation treatment.
Above-mentioned preferred feature can be combined with each other as long as they do not conflict with each other.
In general, by the above technical scheme conceived by the present invention compared with prior art, have below beneficial to effect
Fruit：
1st, coaxial optical path is introduced in the light path of sonde-type co-focusing micro-endoscope, passes through dichroscope and hybrid fiber
High energy laser is coupled into confocal endoscope system by beam, under the auxiliary of the realtime graphic of co-focusing micro-endoscope, right
The early lesion tissue made a definite diagnosis in real time carries out laser ablation treatment, realizes the combination of " diagnosis " and " treatment ", prevents pernicious disease
Disease, such as the further development of canceration；
2nd, the advantages of having combined sonde-type co-focusing micro-endoscope and laser ablation it is burnt not only to extend sonde-type copolymerization
The function of micro-endoscope also reduces the number for the treatment of medical equipment intrusion human body, so as to alleviate the pain of patient, improve and examine
Treat experience；
3rd, for the laser ablation mechanism for the treatment of common sparing light path coaxial with diagnostic imaging mechanism and structure, and
These integrated common sparings are located in vitro, not only reduce equipment volume, but also do not invade human body, and the burnt probe size of copolymerization is small, passes through
Optical fiber transmits, and portion is mobile within the organization for imaging and ablation, be independent of each other during deformation adjustment, stablizes that synchronous, directive property is accurate,
Avoid the complication of maloperation initiation；
4th, light path of the invention passes through the multiple reflections of two dichroscopes and two-dimentional scanning mechanism, transmission so that structure
Characteristics of compact layout occupies little space, and integrated level is high, has saved manufacture cost.
Description of the drawings
Fig. 1 is that the present invention can be with the light path schematic diagram of the sonde-type co-focusing micro-endoscope of laser ablation；
Fig. 2 is the cross-sectional view of the hybrid fiber beam of the present invention；
Fig. 3 is the close-up schematic view of the present invention.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in the various embodiments of the present invention described below
It does not constitute a conflict with each other and can be combined with each other.The present invention is described in more detail With reference to embodiment.
It, can be with the spy of laser ablation as shown in Figure 1, present invention offer is a kind of as a kind of better embodiment of the present invention
Hair style co-focusing micro-endoscope, while have there are two types of the power laser different with effect, one kind is optical excited laser 1, hair
Go out the irradiation laser of low-power, for the imaging of cell grade image, another kind is ablation laser 11, sends out superlaser, is used
In ablation.Further include the first dichroscope 3, two-dimentional scanning mechanism 4, coupling object lens 6, image-carrying fiber bundle 7, miniature object lens 8
And photodetector 10.
The connection relation and position relationship of above each component are that the optical excited laser 1 is arranged on first dichroic
In the incident direction of mirror 3, the two-dimentional scanning mechanism 4 is arranged on the reflection direction of first dichroscope 3, the coupling
Object lens 6 are arranged on the reflection direction of the two-dimentional scanning mechanism 4, and one end of the image-carrying fiber bundle 7 connects the couplings
Mirror 6, the other end connect the miniature object lens 8, and excitation laser is arranged on the lesion portion for focusing on and being colored at the miniature object lens 8
Fluorescence is inspired on position 20, the photodetector 10 is arranged in the fluorescence circuit transmission direction of first dichroscope 3.
The ablation laser 11 is arranged between the two-dimentional scanning mechanism 4 and the coupling object lens 6, and what is sent out disappears
Melt laser and be coupled into the image-carrying fiber bundle 7 and the miniature object lens 8 in a manner of operably coaxial, with formed can be simultaneously
Micro- and laser ablation common focusing probe.
The sonde-type co-focusing micro-endoscope further includes the second dichroscope 12, which is arranged on
In the transmission direction between the two-dimentional scanning mechanism 4 and the coupling object lens 6, excitation laser and fluorescence circuit；It is described to disappear
Melt laser 11 to be arranged in the incident direction of second dichroscope 12, incident ablation laser and second dichroic
The angle of mirror 12 is 45 °, and the coupling object lens 6 are arranged on the reflection direction of ablation laser.
The sonde-type co-focusing micro-endoscope, which further includes, expands microscope group 2, relaying microscope group 5, apeture lens 9, the expansion
Beam microscope group 2 is arranged between the optical excited laser 1 and first dichroscope 3, incident direction of excitation laser；Institute
It states relaying microscope group 5 and is arranged between the two-dimentional scanning mechanism 4 and second dichroscope 12, excitation laser and fluorescence
In light path；The apeture lens 9 is arranged between first dichroscope 3 and the photodetector 10, Fluoroscopic
On direction；The two-dimentional scanning mechanism 4 is composed using galvanometer type galvanometer and mode of resonance galvanometer.
The present invention connection light path be specially：
The optical excited laser 1 sends out excitation laser, is expanded through the microscope group 2 that expands as excitation laser beam, is incident on institute
First dichroscope 3 is stated, is reflected towards the two-dimentional scanning mechanism 4, the two-dimentional scanning mechanism 4 makes excitation laser beam two
Into horizontal deflection in dimension face, deflected light beam by the relaying microscope group 5, transmitted through second dichroscope 12, using
Focal spot corresponding with scanning mode is formed one by one after the coupling object lens 6, these focal spots progressively scan the biography picture
7 proximal face of fiber optic bundle is simultaneously implanted sequentially in the fibre core of image-carrying fiber bundle, the excitation after being transmitted via the image-carrying fiber bundle 7
Laser is focused on the lesions position 20 (stomach of such as epithelial metaplasia) being colored by the miniature object lens 8 of image-carrying fiber bundle distal end
On；
The lesions position 20 the being colored fluorescence sent out after laser stimulation that is excited is returned along original optical path, is passed sequentially through described
Miniature object lens 8, image-carrying fiber bundle 7, coupling object lens 6, the second dichroscope 12, relaying microscope group 5, two-dimentional scanning mechanism the 4, the 1st
Reach on the photodetector 10 to Look mirror 3, apeture lens 9 etc., by image mosaic and image enhancement processing algorithm, obtain
A series of cell grade image of lesions positions 20 being colored provides realtime graphic auxiliary for diagnosis；
Meanwhile the coaxial optical path of ablation laser is also introduced in above-mentioned light path, the ablation laser 11 sends out high energy
Laser is melted, is incident to second dichroscope 12, then reflexes to the coupling object lens 6, is coupled into institute in coaxial fashion
The common focusing probe that image-carrying fiber bundle 7 and miniature object lens 8 form is stated, ablation laser focuses on the lesions position 20 being colored, makes
The high-energy that must be focused on makes pathological tissues quickly inactivate, apoptosis, gasification, the cell melted due to gasification, tissue inhaled by body
It receives, so as to make foci disappearance, realizes real time laser ablation.
Sonde-type co-focusing micro-endoscope further includes circuit module 13, and connection controls the optical excited laser 1, ablation
Laser 11 and photodetector 10 connect the circuit module 13 including foot-operated ancillary equipment, to be sent to signal, open
The ablation laser 11 realizes laser ablation treatment.
The present invention introduces coaxial optical path in the light path of sonde-type co-focusing micro-endoscope, passes through dichroscope and mixing
High energy laser is coupled into confocal endoscope system by fiber optic bundle, in the auxiliary of the realtime graphic of co-focusing micro-endoscope
Under, veteran doctor is helped to make care diagnostic, and sent out according to the state of an illness by the ancillary equipments such as foot-operated to circuit module 13
The number of delivering letters opens high-energy ablation laser 11, carries out real time laser ablation to certain early lesion tissues, realizes
" diagnosis " and the combination of " treatment ", prevents malignant disease, such as the further development of canceration.
The present invention has combined the advantages of sonde-type co-focusing micro-endoscope and laser ablation, not only extends sonde-type and is total to
The function of micro-endoscope is focused on, also reduces the number for the treatment of medical equipment intrusion human body, so as to alleviate the pain of patient, improve
Diagnosis and treatment experience.
As shown in Fig. 2, the image-carrying fiber bundle 7 of the present invention has used a kind of hybrid fiber beam of specific customization, in interior
Outer three-decker is an energy transmission optical fibre 72 at internal layer center, and the middle layer outside the energy transmission optical fibre 72 is equipped with
Tens thousand of single mode optical fibers 71, outermost layer are dope layer 73.The ablation laser that the ablation laser 11 is sent out is in coaxial fashion
The common focusing probe of the energy transmission optical fibre 72 being coupled into the image-carrying fiber bundle 7 and the miniature object lens 8 composition.
Preferably, the diameter of the hybrid fiber beam is between 600 μm~1500 μm；The energy transmission optical fibre 72 it is straight
For diameter between 25 μm~125 μm, core material is high purity quartz, and clad material is fluorine-doped quartz；The single mode optical fiber 71 it is straight
For diameter between 1~5 μm, core material is high purity quartz；The dope layer 73 is polymer plastic.
The hybrid fiber beam toughness of specific customization is strong, resistant to bending, can bear radius of curvature 30mm or so under normal circumstances
Bending.
In the present invention, for treatment the coaxial common sparing light path of laser ablation mechanism and diagnostic imaging mechanism and
Structure, and these integrated common sparings are located in vitro, have not only reduced equipment volume, but also do not invade human body, are copolymerized burnt probe size
It is small, it is transmitted by optical fiber, is imaged, deformation adjustment mobile with portion within the organization of melting and is independent of each other in the process, stablizes synchronous, direction
Property it is accurate, avoid maloperation initiation complication.
For existing straightline propagation endoscope in the majority and ablation needle construction, light path of the invention passes through two
The multiple reflections of dichroscope and two-dimentional scanning mechanism etc., transmission so that structure characteristics of compact layout occupies little space, improves hand
The space availability ratio of art room, integrated level is high, has saved manufacture cost.
Two surfaces of second dichroscope 12 are plated with special film layer, such special film layer not only it is anti-reflection by
Excitation laser and the lesions position 20 by being colored that the optical excited laser 1 is sent out excite and return the fluorescence of original optical path,
There must also be very high reflex to the ablation laser that the ablation laser 11 is sent out.
The ablation laser that the ablation laser 11 is emitted is continuous laser or short-pulse laser；Preferably, peak
Value, the short-pulse laser that wavelength is 980nm, because the laser of wavelength 980nm can close the blood vessel and lymphatic vessel of neoplastic lesion,
And it can strongly be absorbed by water and hemoglobin, therefore have more superior gasification to pathological tissues, it in addition to this can be with
Select 808nm, 1064nm equiwavelength for having fine penetrability to tissue.
As shown in figure 3, the excitation laser (such as 488nm) that the miniature object lens 8 not only send out the optical excited laser 1,
The fluorescence (such as 520nm) for also exciting and returning to the lesions position 20 being colored carries out anaberration, image quality optimization.
Each minute surface of the miniature object lens 8 must also increase corresponding wavelength (such as 980) specially treated of ablation laser, such as plating
Permeable membrane layer eliminates the processing such as internal focus point, so as to increase the transmission characteristic of ablation laser, avoids the ablation laser of high energy by mirror
High temperature increases and damages the miniature object lens 8 in piece absorption or internal focus rear lens.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, all any modification, equivalent and improvement made all within the spirits and principles of the present invention etc., should all include
Within protection scope of the present invention.
Claims (10)
1. a kind of can be with the sonde-type co-focusing micro-endoscope of laser ablation, it is characterised in that：Including two different laser
Device, one kind are optical excited laser (1), and another kind is ablation laser (11)；
Further include the first dichroscope (3), two-dimentional scanning mechanism (4), coupling object lens (6), image-carrying fiber bundle (7), miniature object lens
(8) and photodetector (10)；
The optical excited laser (1) is arranged in the incident direction of first dichroscope (3), the two-dimentional scanning mechanism
(4) it is arranged on the reflection direction of first dichroscope (3), the coupling object lens (6) are arranged on the area scanner
On the reflection direction of structure (4), one end connection coupling object lens (6) of the image-carrying fiber bundle (7), other end connection are described micro-
Type object lens (8), excitation laser be arranged at the miniature object lens (8) focus on the lesions position (20) being colored inspire it is glimmering
Light, the photodetector (10) are arranged in the fluorescence circuit transmission direction of first dichroscope (3)；
The ablation laser (11) is arranged between the two-dimentional scanning mechanism (4) and the coupling object lens (6), is sent out
Ablation laser is coupled into the image-carrying fiber bundle (7) and the miniature object lens (8) in coaxial fashion, can be micro- simultaneously with formation
With the confocal endoscope system of laser ablation.
It 2. as described in claim 1 can be with the sonde-type co-focusing micro-endoscope of laser ablation, it is characterised in that：The spy
Hair style co-focusing micro-endoscope further includes the second dichroscope (12), which is arranged on the two dimension and sweeps
In the transmission direction for retouching between mechanism (4) and the coupling object lens (6), excitation laser and fluorescence circuit；The ablation laser
Device (11) is arranged in the incident direction of second dichroscope (12), incident ablation laser and second dichroscope
(12) angle is 45 °, and the coupling object lens (6) are arranged on the reflection direction of ablation laser.
It 3. as claimed in claim 2 can be with the sonde-type co-focusing micro-endoscope of laser ablation, it is characterised in that：The spy
Hair style co-focusing micro-endoscope, which further includes, expands microscope group (2), relaying microscope group (5), apeture lens (9), described to expand microscope group (2)
It is arranged between the optical excited laser (1) and first dichroscope (3), the incident direction of excitation laser；It is described
Relaying microscope group (5) is arranged between the two-dimentional scanning mechanism (4) and second dichroscope (12), excitation laser and glimmering
In the light path of light；The apeture lens (9) is arranged between first dichroscope (3) and the photodetector (10)
, on Fluoroscopic direction；
The two-dimentional scanning mechanism (4) is composed using galvanometer type galvanometer and mode of resonance galvanometer.
It 4. as claimed in claim 3 can be with the sonde-type co-focusing micro-endoscope of laser ablation, which is characterized in that sonde-type
The connection light path of co-focusing micro-endoscope is：
The optical excited laser (1) sends out excitation laser, is expanded through the microscope group (2) that expands as excitation laser beam, is incident on institute
First dichroscope (3) is stated, is reflected towards the two-dimentional scanning mechanism (4), the two-dimentional scanning mechanism (4) makes excitation laser
Beam in two-dimensional surface into horizontal deflection, deflected light beam by the relaying microscope group (5), transmitted through second dichroscope
(12), using focal spot corresponding with scanning mode is formed one by one after the coupling object lens (6), these focal spots are line by line
It scans the image-carrying fiber bundle (7) proximal face and is implanted sequentially in the fibre core of image-carrying fiber bundle, via the image transmission optical fibre
Excitation laser after beam (7) transmits is focused on the lesions position being colored by the miniature object lens (8) of image-carrying fiber bundle distal end
(20) on；
The lesions position (20) the being colored fluorescence sent out after laser stimulation that is excited is returned along original optical path, is passed sequentially through described micro-
Type object lens (8), image-carrying fiber bundle (7), coupling object lens (6), the second dichroscope (12), relaying microscope group (5), two-dimentional scanning mechanism
(4), the first dichroscope (3), apeture lens (9) reach on the photodetector (10), increase by image mosaic and image
Strong Processing Algorithm obtains a series of cell grade images of lesions position (20) being colored, and realtime graphic auxiliary is provided for diagnosis；
Meanwhile coaxial optical path is also introduced, the ablation laser (11) sends out high energy ablation laser, is incident to the described 2nd 2
To Look mirror (12), the coupling object lens (6) are reflexed to, are coupled into the image-carrying fiber bundle (7) and miniature object in coaxial fashion
The common focusing probe of mirror (8) composition, ablation laser focus on the lesions position (20) being colored so that the high-energy of focusing makes disease
Become tissue quickly inactivate, apoptosis, gasification, the cell melted due to gasification, tissue be absorbed by organisms, so as to make foci disappearance,
Realize real time laser ablation.
5. as claim 2-4 any one of them can be existed with the sonde-type co-focusing micro-endoscope of laser ablation, feature
In：Two surfaces of second dichroscope (12) are plated with film layer, and the film layer is anti-reflection to be sent out by the optical excited laser (1)
Excitation laser and the lesions position 20 by being colored excite and return the fluorescence of original optical path, and reflect by the ablation laser
The ablation laser that device (11) is sent out.
6. as claim 1-4 any one of them can be existed with the sonde-type co-focusing micro-endoscope of laser ablation, feature
In：The image-carrying fiber bundle (7) is a kind of hybrid fiber beam, is an energy at internal layer center including inside and outside three-decker
Transmission Fibers (72) are equipped with tens thousand of single mode optical fibers (71) in the middle layer of the energy transmission optical fibre (72) outside, and outermost layer is
Dope layer (73).
It 7. as claimed in claim 6 can be with the sonde-type co-focusing micro-endoscope of laser ablation, it is characterised in that：It is described mixed
The diameter of fiber optic bundle is closed between 600 μm~1500 μm；
The diameter of the energy transmission optical fibre (72) is between 25 μm~125 μm, and core material is high purity quartz, and clad material is
Fluorine-doped quartz；
For the diameter of the single mode optical fiber (71) between 1~5 μm, core material is high purity quartz；
The dope layer (73) is polymer plastic.
8. as claim 1-4 any one of them can be existed with the sonde-type co-focusing micro-endoscope of laser ablation, feature
In：
The ablation laser of ablation laser (11) outgoing is continuous laser or short-pulse laser；Preferably, for gas
The short-pulse laser that the wavelength of change is 980nm or the short-pulse laser that the wavelength convenient for penetrating is 808nm, 1064nm.
9. as claim 1-4 any one of them can be existed with the sonde-type co-focusing micro-endoscope of laser ablation, feature
In：The excitation laser that the miniature object lens (8) not only send out the optical excited laser (1), the also lesions position to being colored
(20) fluorescence for exciting and returning carries out anaberration, image quality optimization；Preferably, the excitation laser wavelength is 488nm, described glimmering
The wavelength of light is 520nm；
Each minute surface of the miniature object lens (8) carries out including plating antireflective coating, eliminates inside for the corresponding wavelength of ablation laser
The processing of focus point so as to increase the transmission characteristic of ablation laser, avoids the ablation laser of high energy by eyeglass absorption or inside
It focuses on high temperature raising in rear lens and damages the miniature object lens (8).
10. as claim 1-4 any one of them can be with the sonde-type co-focusing micro-endoscope of laser ablation, feature
It is：Sonde-type co-focusing micro-endoscope further includes circuit module (13), and connection controls the optical excited laser (1), disappears
Melt laser (11) and photodetector (10), the circuit module (13) is connected including foot-operated ancillary equipment, to be sent to
Signal opens the ablation laser (11) and realizes laser ablation treatment.
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