CN110623856A - Lecithin emulsion without emulsifier and preparation method thereof - Google Patents
Lecithin emulsion without emulsifier and preparation method thereof Download PDFInfo
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- CN110623856A CN110623856A CN201910986252.9A CN201910986252A CN110623856A CN 110623856 A CN110623856 A CN 110623856A CN 201910986252 A CN201910986252 A CN 201910986252A CN 110623856 A CN110623856 A CN 110623856A
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- lecithin
- emulsifier
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The present invention provides a lecithin emulsion containing no emulsifier, comprising: 65-95 wt% of an aqueous phase, 1-30 wt% of an oil phase and 1-5 wt% of lecithin. The invention also provides a method for preparing the lecithin emulsion without the emulsifier. The invention also provides the application of the lecithin emulsion without the emulsifier in the preparation of cosmetics.
Description
Technical Field
The invention provides a lecithin emulsion without an emulsifier and a preparation method thereof.
Background
In 1844 Gohley, French, discovered lecithin from egg yolk and was named Lecithos (lecithin) in Greek. Lecithin is a mixture of animal and plant tissues and yolk, and is a yellow brown greasy substance, and its components include phosphoric acid, choline, fatty acid, glycerol, glycolipid, triglyceride and phospholipid.
Lecithin is an important component of cell membranes and has extremely high biocompatibility. Lecithin is broadly defined as a variety of phospholipid products, including Phosphatidylcholine (PC), Phosphatidylethanolamine (PE), Phosphatidic Acid (PA), Phosphatidylinositol (PI), etc., and in the narrow sense, lecithin refers to phosphatidylcholine. The higher the purity of PC, the smaller the odor and the stronger the emulsifying property. The lecithin has a tail with a double-hydrophobic structure, can be directly dispersed in water to form vesicles which are in an ordered phospholipid bilayer structure, so that the lecithin meets the condition of an emulsifier in the surfactant and can serve as the emulsifier to a certain extent.
However, lecithin is a low-polarity oily substance, is insoluble in water, and needs to be kept at a high temperature for a long time in oil to be dissolved, and is solidified when the temperature is slightly lowered, so that the lecithin is extremely unfriendly to the process. Wherein high purity lecithin (phosphatidylcholine > 90%) is not dissolved even in common vegetable oil and fat. Therefore, the application of lecithin as an emulsifier in cosmetics generally requires the complex use of other emulsifiers.
Disclosure of Invention
The inventor unexpectedly finds that the emulsifying property of lecithin can be activated by the relay emulsifying method, and the lecithin with the improved emulsifying property can be independently used in cosmetics as an emulsifying agent without compounding other emulsifying agents. Accordingly, the present invention provides an emulsifier-free lecithin emulsion and a method for preparing the same. The invention activates the emulsifying property of lecithin by a relay emulsifying method, and can maintain the stability of an emulsified body without compounding other emulsifying agents, thereby greatly expanding the application of the lecithin in cosmetics.
A first aspect of the present invention provides a lecithin emulsion containing no emulsifier, the lecithin emulsion comprising: 65-95 wt% of an aqueous phase, 1-30 wt% of an oil phase and 1-5 wt% of lecithin.
According to a preferred embodiment of the invention, the emulsifier-free lecithin emulsion comprises: the composition comprises: 75-90 wt% of an aqueous phase, 1-25 wt% of an oil phase and 1-3 wt% of lecithin.
More preferably, the emulsifier-free lecithin emulsion comprises: the composition comprises: 75-90 wt% of an aqueous phase, 1-25 wt% of an oil phase and 1-1.5 wt% of lecithin.
According to another preferred embodiment of the present invention, in the emulsifier-free lecithin emulsion, the aqueous phase is selected from at least one of water, glycerin and glycol.
According to a preferred embodiment of the present invention, the diol may be selected from at least one of 1, 3-propanediol, 1, 2-propanediol, 1, 3-butanediol, 1, 2-pentanediol, and 1, 2-hexanediol.
According to a preferred embodiment of the present invention, in the emulsifier-free lecithin emulsion, the oil phase may be selected from at least one of squalane, sunflower oil, olive oil, jojoba oil and cetearyl alcohol.
According to a particularly preferred embodiment of the invention, the emulsifier-free lecithin emulsion comprises: 50-70 wt% of water, 10-30 wt% of glycerol, 1-30 wt% of squalane, 1-5 wt% of 1, 3-propanediol and 1-5 wt% of lecithin.
More preferably, the emulsifier-free lecithin emulsion comprises: 50-70 wt% of water, 10-30 wt% of glycerol, 1-30 wt% of squalane, 1-5 wt% of 1, 3-propanediol and 1-1.5 wt% of lecithin.
According to a most preferred embodiment of the invention, the emulsifier-free lecithin emulsion consists of 50 to 70% by weight of water, 10 to 30% by weight of glycerol, 1 to 30% by weight of squalane, 1 to 5% by weight of 1, 3-propanediol and 1 to 5% by weight of lecithin.
More preferably, the emulsifier-free lecithin emulsion is composed of 50 to 70% by weight of water, 10 to 30% by weight of glycerin, 1 to 30% by weight of squalane, 1 to 5% by weight of 1, 3-propanediol, and 1 to 1.5% by weight of lecithin.
According to a preferred embodiment of the present invention, the lecithin may be selected from soybean lecithin, egg yolk lecithin, hydrogenated lecithin, hydroxylated lecithin, and the like.
The relay emulsification method is a method for firstly forming a relay composition in the process of preparing lecithin emulsion and then adding water phase for emulsification, wherein the relay composition is lecithin multiphase gel.
Accordingly, a second aspect of the present invention provides a method for preparing the emulsifier-free lecithin emulsion, comprising the steps of: dispersing lecithin in an oil phase, adding a part of an aqueous phase, stirring to be gelatinous to form a lecithin multiphase gel, and finally adding the lecithin multiphase gel into the other part of the aqueous phase for emulsification.
According to a preferred embodiment of the present invention, the one part of the aqueous phase is a polyhydric alcohol, and the other part of the aqueous phase is water.
According to a preferred embodiment of the invention, when the aqueous phase is chosen from water, glycerol and 1, 3-propanediol and the oily phase is chosen from squalane, the lecithin multiphase gel according to the invention is a three-phase gel of lecithin, squalane and 1, 3-propanediol. In this case, the method for preparing the emulsifier-free lecithin emulsion includes the steps of:
1) the lecithin is dispersed in the squalane and,
2) adding 1, 3-propylene glycol, stirring to gel,
3) adding glycerol, homogenizing, dispersing completely, cooling to obtain three-phase gel of lecithin, squalane and 1, 3-propylene glycol, and
4) adding the three-phase gel of lecithin, squalane and 1, 3-propylene glycol into water for emulsification.
According to a preferred embodiment of the invention, the weight content ratio of lecithin to squalane to 1, 3-propanediol in the lecithin three-phase gel of step 3) above is 1-5:1-20:1-5, preferably 1-1.5:1-10: 1-5.
According to a most preferred embodiment of the invention, in step 1), the lecithin is dispersed in squalane at a temperature of 80 to 85 ℃.
According to another most preferred embodiment of the invention, in step 3), cooling to room temperature is carried out to obtain a three-phase gel of said lecithin, squalane and 1, 3-propanediol.
The third aspect of the present invention provides the use of the emulsifier-free lecithin emulsion of the present invention for the preparation of cosmetics.
According to a preferred embodiment of the invention, the cosmetic product is an emulsion.
Compared with the emulsifying body in the prior art, the lecithin emulsifying body without the emulsifying agent has the advantages that:
1. lecithin can be used as an emulsifier for cosmetics independently without being compounded with other emulsifiers, so that the cost is reduced and the tolerance is increased;
2. the invention adopts the relay emulsification method to activate the emulsifying property of the lecithin, and can maintain the stability of an emulsified body under the condition of not compounding other emulsifying agents, thereby greatly expanding the application of the lecithin in cosmetics and being used for developing cosmetic compositions without emulsifying agents.
Drawings
FIG. 1 shows a heterogeneous gel of lecithin prepared in example 1.
FIG. 2 shows the lecithin emulsion prepared in example 1.
Detailed Description
Example 1: preparation of lecithin emulsion of the present invention
| Serial number | Name of Chinese | Content (g) |
| 1 | Water (W) | 68 |
| 2 | Glycerol | 20 |
| 3 | Cetostearyl alcohol | 10 |
| 1, 2-pentanediol | 1 | |
| 4 | Lecithin | 1 |
The preparation method comprises the following steps: adding 1g lecithin into 10g cetearyl alcohol and 1, 2-pentanediol, stirring, dissolving, dispersing, adding 20g glycerol, homogenizing to obtain lecithin multiphase gel, adding 68g water, and homogenizing to obtain lecithin emulsion.
Example 2: preparation of lecithin emulsion of the present invention
The preparation method comprises the following steps: adding 1g lecithin into 5g squalane and 1g 1, 3-propylene glycol, stirring for dissolving and dispersing, adding 30g glycerol, homogenizing to obtain lecithin multiphase gel, adding 63g water, and homogenizing to obtain lecithin emulsion.
Example 3: preparation of lecithin emulsion of the present invention
| Serial number | Name of Chinese | Content (g) |
| 1 | Water (W) | 30 |
| 2 | Glycerol | 30 |
| 3 | Jojoba oil | 30 |
| 4 | 1, 3-butanediol | 5 |
| 5 | Lecithin | 5 |
The preparation method comprises the following steps: adding 5g of lecithin into 30g of jojoba oil and 5g of 1, 3-butanediol, stirring, dissolving, dispersing, adding 30g of glycerol, homogenizing to obtain lecithin multiphase gel, adding 30g of water, and homogenizing to obtain lecithin emulsion.
Example 4: preparation of lecithin emulsion of the present invention
| Serial number | Name of Chinese | Content (g) |
| 1 | Water (W) | 57 |
| 2 | Glycerol | 30 |
| 3 | Squalane | 10 |
| 4 | 1,2 hexanediol | 1.5 |
| 5 | Lecithin | 1.5 |
The preparation method comprises the following steps: adding 1.5g lecithin into 10g squalane and 1.5g 1, 2-hexanediol, stirring, dissolving, dispersing, adding 30g glycerol, homogenizing to obtain lecithin multiphase gel, adding 57g water, and homogenizing to obtain lecithin emulsion.
Example 5: preparation of an emulsion Using the lecithin emulsion of the invention
The preparation method comprises the following steps:
adding 1g lecithin into 5g squalane and 1g 1, 3-propylene glycol, stirring for dissolving and dispersing, adding 30g glycerol, homogenizing to obtain lecithin multiphase gel, adding 63g water and 0.1g dipotassium glycyrrhizinate, homogenizing to obtain lecithin emulsion, adding 0.1g sodium polyacrylate, homogenizing, completely dispersing, adding 0.1g essence and 0.3g phenoxyethanol to obtain emulsion.
Experimental example 1: evaluation of stability of lecithin emulsions prepared in examples 1 to 4 of the present invention and emulsions prepared in example 5
The lecithin emulsions and emulsions prepared in examples 1 to 5 of the present invention were placed in a biological incubator at 5 ℃ and 40 ℃ and circulating (-5 ℃ to 40 ℃ C., cycle 24 hours) and at room temperature, respectively, and observed every other week, and the results are shown in the following table.
The above results show that the lecithin emulsions and emulsions prepared in examples 1-5 of the present invention are stable for three months at 5 deg.C, 40 deg.C, circulating (-5-40 deg.C, period 24h) in a biological incubator and at room temperature, and thus meet the stability requirements. Therefore, the lecithin emulsion can maintain the stability of the emulsion without being compounded with other emulsifiers.
Experimental example 2: evaluation of emulsifying Capacity of lecithin emulsion produced according to the invention
The emulsifying ability of each of the above lecithin emulsions was first evaluated by a conventional centrifugation test at 2000rpm/min for 30min at 25 ℃. To further evaluate the relative emulsifying ability of each of the above lecithin emulsions, a high-temperature centrifugation experiment was performed at 2000rpm/min at 40 ℃ for each of the lecithin emulsions without separation after the conventional centrifugation experiment until the point of its centrifugal breakdown was reached.
The emulsion of comparative example 1, prepared using sucrose laurate as the emulsifier, was also used as a control, and the composition of the emulsion of comparative example 1 is shown in the following table:
| serial number | Name of Chinese | Content (g) |
| 1 | Water (W) | 63 |
| 2 | Glycerol | 30 |
| 3 | Squalane | 5 |
| 4 | 1, 3-propanediol | 1 |
| 5 | Sucrose laurate | 1 |
The preparation method of the emulsion of comparative example 1 described above was as follows:
adding sucrose laurate 1g into water 63g and propylene glycol 1g and glycerol 30g, stirring for dissolving, heating to 60-65 deg.C, adding squalane 5g, and homogenizing with MARK II homogenizer of PRIMIX to obtain oil-in-water emulsion.
From the above results, it is understood that the emulsifying ability is the lecithin emulsion of example 2 > the lecithin emulsion of example 4 > the lecithin emulsion of example 3 ≈ the lecithin emulsion of example 1 ≈ the emulsion of comparative example 1. In general, the emulsifying ability of the lecithin emulsion containing no emulsifier according to the present invention was substantially equivalent to that of comparative example 1 containing an emulsifier, and the minimum emulsifying ability required as an emulsifier for cosmetic compositions was satisfied, so that it was possible to develop a cosmetic composition containing no emulsifier without compounding other emulsifiers.
Claims (16)
1. A lecithin emulsion that does not contain an emulsifier, wherein the lecithin emulsion comprises: 65-95 wt% of an aqueous phase, 1-30 wt% of an oil phase and 1-5 wt% of lecithin.
2. The emulsifier-free lecithin emulsion according to claim 1, wherein the lecithin emulsion comprises: 75-90 wt% of an aqueous phase, 5-25 wt% of an oil phase and 1-3 wt% of lecithin.
3. The emulsifier-free lecithin emulsion according to claim 1 or 2, wherein the aqueous phase is selected from at least one of water, glycerin and glycol.
4. The emulsifier-free lecithin emulsion according to claim 3, wherein the diol is at least one selected from the group consisting of 1, 3-propanediol, 1, 2-propanediol, 1, 3-butanediol, 1, 2-pentanediol and 1, 2-hexanediol.
5. The emulsifier-free lecithin emulsion according to claim 1 or 2, wherein the oil phase is selected from at least one of squalane, sunflower oil, olive oil, jojoba oil and cetearyl alcohol.
6. The emulsifier-free lecithin emulsion according to claim 1 or 2, wherein the lecithin emulsion comprises: 50-70 wt% of water, 10-30 wt% of glycerol, 1-30 wt% of squalane, 1-5 wt% of 1, 3-propanediol and 1-5 wt% of lecithin.
7. The emulsifier-free lecithin emulsion according to claim 1 or 2, wherein the lecithin emulsion consists of 50-70 wt% of water, 10-30 wt% of glycerol, 1-30 wt% of squalane, 1-5 wt% of 1, 3-propanediol and 1-5 wt% of lecithin.
8. A process for preparing an emulsifier-free lecithin emulsion according to any one of claims 1 to 7, comprising the steps of: dispersing lecithin in an oil phase, adding a part of an aqueous phase, stirring to be gelatinous to form a lecithin multiphase gel, and finally adding the lecithin multiphase gel into the other part of the aqueous phase for emulsification.
9. The method for producing an emulsifier-free lecithin emulsion according to claim 1, wherein the part of the aqueous phase is a polyol.
10. The method for producing an emulsifier-free lecithin emulsion according to claim 1, wherein the other part of the aqueous phase is water.
11. A process for preparing the emulsifier-free lecithin emulsion according to any one of claims 4 to 7, comprising the steps of:
1) the lecithin is dispersed in the squalane and,
2) adding 1, 3-propylene glycol, stirring to gel,
3) adding glycerol, homogenizing, dispersing completely, cooling to obtain three-phase gel of lecithin, squalane and 1, 3-propylene glycol, and
4) and adding the three-phase gel into water for emulsification.
12. The method according to claim 11, wherein the weight content ratio of lecithin to squalane to 1, 3-propanediol in the three-phase gel of step 3) is 1-5:1-20: 1-5.
13. The method according to claim 12, wherein the weight content ratio of lecithin to squalane to 1, 3-propanediol in the three-phase gel of step 3) is 1-1.5:1-10: 1-5.
14. The process according to claim 11, wherein in step 1), lecithin is dispersed in squalane at a temperature of 80-85 ℃.
15. The method of claim 11, wherein in step 3), cooling to room temperature to obtain the three-phase gel.
16. Use of the emulsifier-free lecithin emulsion according to any one of claims 1 to 7 for the preparation of cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910986252.9A CN110623856A (en) | 2019-10-17 | 2019-10-17 | Lecithin emulsion without emulsifier and preparation method thereof |
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| CN201910986252.9A CN110623856A (en) | 2019-10-17 | 2019-10-17 | Lecithin emulsion without emulsifier and preparation method thereof |
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| CN110623856A true CN110623856A (en) | 2019-12-31 |
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|---|---|---|---|
| CN201910986252.9A Pending CN110623856A (en) | 2019-10-17 | 2019-10-17 | Lecithin emulsion without emulsifier and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467272A (en) * | 2020-04-20 | 2020-07-31 | 上海九乙生物科技有限公司 | Guava extract and lecithin composition and application thereof |
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- 2019-10-17 CN CN201910986252.9A patent/CN110623856A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467272A (en) * | 2020-04-20 | 2020-07-31 | 上海九乙生物科技有限公司 | Guava extract and lecithin composition and application thereof |
| CN111467272B (en) * | 2020-04-20 | 2022-12-02 | 上海九乙生物科技有限公司 | Guava extract and lecithin composition and application thereof |
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