CN107308019A - A kind of improved emulsifying agent and preparation method thereof - Google Patents
A kind of improved emulsifying agent and preparation method thereof Download PDFInfo
- Publication number
- CN107308019A CN107308019A CN201710437802.2A CN201710437802A CN107308019A CN 107308019 A CN107308019 A CN 107308019A CN 201710437802 A CN201710437802 A CN 201710437802A CN 107308019 A CN107308019 A CN 107308019A
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- CN
- China
- Prior art keywords
- lecithin
- peg
- coemulsifier
- solid lipid
- emulsifying agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
Abstract
The invention provides a kind of improved emulsifying agent, by lecithin, coemulsifier and solid lipid composition, the mass percent of lecithin is 5 45%；The mass percent of coemulsifier is 5 30%；The mass percent of solid lipid is 30 70%.Present invention also offers the preparation method of mentioned emulsifier, first by solid lipid heating and melting, lecithin is then added, heating stirring is to homogeneous, add coemulsifier, heating stirring to being down to room temperature in the lump, you can obtains the emulsifier mixture for preparing the serial cosmetics containing liquid crystal structure.
Description
Technical field
The invention belongs to cosmetic field, it is related to a kind of improved emulsifying agent and preparation method thereof.
Background technology
The emulsifying agent of liquid crystal can be formed mainly including following several：Lecithin lipid, glucose glycoside, sucrose ester, phosphorus
Esters of gallic acid, olive esters and stearoyl class etc..The liquid crystal emulsifier of wherein natural origin has lecithin lipid, glucose glycoside, sugarcane
Sugar esters and olive esters.
Lecithin is powered amphoteric surfactant, with amphiphile, amphiphilic molecule structure, and the group such as phosphoric acid and choline is hydrophilic
Base, can be dissolved in water lecithin；Two fatty acid chains are hydrophobic group, and it can be such that phosphide is dissolved in oil or fat.Lecithin
Fat is as surface reactive material, with some row interfaces and colloidal nature, such as Interfacial Adsorption, formation micelle, emulsification, generation
Liquid crystal and liposome etc..
Liquid crystal is a kind of Thermodynamically stable phase between crystalline state, and it is in a kind of state not being completely dissolved, has
Certain thermodynamic stability.Emulsion containing liquid crystal structure is mainly the emulsifying agent with unique texture and answered with suitable grease
Match somebody with somebody, form a kind of orderly align.Cosmetics contain liquid crystal structure, with increase emulsion stability, enhancing moisture retention,
Control the effects such as medicament slow release effect and excellent skin sense.
It is more as the research of food emulsifying agent on lecithin at present, but if separately as cosmetic emulsifier, ovum
It is not enough to there is emulsification dynamics in phosphatide, it is difficult to not yet effectively solved the problems such as formation rule degree relatively high and stable liquid-crystal emulsion
Certainly.
The content of the invention
For above-mentioned technical problem of the prior art, the invention provides a kind of improved emulsifying agent and its preparation side
Method, described this improved emulsifying agent and preparation method thereof will solve lecithin of the prior art and there is emulsification dynamics not
Foot, it is difficult to the technical problem of the relatively high and stable liquid-crystal emulsion of formation rule degree.
The invention provides a kind of improved emulsifying agent, calculate by mass percentage, its raw material composition and content are as follows：
Lecithin 5-45%；
Coemulsifier 5-30%；
Solid lipid 30-70%；
Described lecithin is one or both of soybean lecithin, egg yolk lecithin, hydrolecithin, hydroxylated lecithin
Combination above；
Described coemulsifier is ceteareth -25, ceteareth -6, ceteareth -12, whale
Wax stereth -20, ceteareth -30, stereth -2, stereth -21, dehydration sorbic alcohol oleic acid
Ester, dehydration sorbic alcohol stearate, dehydration sorbic alcohol laurate, polyoxyethylene sorbitan sorbic alcohol oleate, polyoxyethylene lose
The double oleic acid of water sorbic alcohol stearate, polyoxyethylene sorbitan sorbic alcohol laurate, PEG-20 tribehenins acid glyceride, PEG-8
The double stearates of ester, PEG-8, PEG-4 laurates, PEG-8 oleates, PEG-8 stearates, PEG-8 beeswaxs, PEG-20 are hard
Resin acid ester or PEG-32 stearates, Cremophor RH40, PEG-20 octadecyl alcolols ether, 16 stearyl alcohols and 16
Eight APGs, 16 stearyl alcohols and coconut alkyl glucosides, 16 stearyl alcohols and eicosyl glucoside, C14-
Combinations more than one or both of 22 alkylols etc.；
Described solid lipid is saturated fat acids, aliphatic alcohols, steroid, glyceride type, wax class, hydrogenated castor
Combination more than one or both of oil, the hard ester alcohol of spermaceti, hard ester alcohol, pentaerythritol stearic acid ester 2.
Present invention also offers a kind of above-mentioned preparation method of improved emulsifying agent, it is first according to mass percent and weighs ovum
Phosphatide, coemulsifier and solid lipid；Then solid lipid is heated to 65 ~ 90 DEG C of thawings, adds lecithin, heating is stirred
Mix to homogeneous, be eventually adding coemulsifier, be heated to 65 ~ 90 DEG C, stirring to being down to room temperature in the lump.
The present invention principle be：Lecithin is a kind of mixture, mainly comprising phosphatidyl choline（PC）, phosphatidyl-ethanolamine
（PE）Phosphatidylinositols（PI）, phosphatidylserine（PS）Deng.Because lecithin has the tail of double hydrophobic structures, directly in water
In disperse that vesica can be formed, be orderly phospholipid bilayer Rotating fields, it is observed that liquid crystal under petrographic microscope.But work as
During using phosphatide as emulsifier grease, because the PC in mixture may advantageously facilitate the formation of O/W type emulsions, PE is conducive to
Promote the formation of w/o type emulsion, the two mutually suppresses, and causes the hydrophilic lipophilic balance of lecithin（HLB value）It is low, emulsifying capacity
It is not strong, it significantly limit application of the lecithin in cosmetics.Therefore, during using lecithin as primary emulsion, in order to make up
Its weaker emulsifying capacity, need to compound other common emulsifying agents, but both emulsifying agents are when being distributed in the interface of water-oil phase, difficult
To form layer structure, so that more difficult formation liquid crystal；In addition, the critical Packing parameter of lecithin（CPP）It is very small, it is more difficult to be formed
Layered liquid crystal, adds solid lipid, the long hydrophobic chain of solid lipid can be inserted on oil-water interfacial film, advantageously forms stabilization
Layer structure, so as to form liquid crystal.
The present invention is compared with prior art, and its technological progress is significant.The present invention is due to using lecithin, co-emulsifier
Agent and solid lipid compounding, obtain the emulsifier mixture for preparing the serial cosmetics containing liquid crystal structure.
Brief description of the drawings
Fig. 1 is that the emulsion for preparing of emulsifying agent of the embodiment of the present invention 1 amplifies 100 times under petrographic microscope
Microphotograph figure.
Specific implementation method
The present invention is expanded on further below by specific embodiment.It is as described below be only embody the purpose of the present invention, effect and
The embodiment of technology path, but protection domain not thereby limiting the invention.
Embodiment 1
A kind of improved emulsifying agent, is calculated by mass percentage, and its raw material composition and content are as follows：
Lecithin 20%
Coemulsifier 10%
Solid lipid 70%
Described lecithin is hydrolecithin；
Described coemulsifier is polyoxyethylene sorbitan sorbic alcohol oleate；
Described solid lipid is steroids（Cholesterol）, fatty alcohol（16 carbon alcohol, octadecanol）And glycerolipid（It is single stearic
Acid glyceride）Calculate in mass ratio, i.e. cholesterol：16 carbon alcohol：Octadecanol：Glycerin monostearate=1:1:1:1 composition
Mixture；
A kind of above-mentioned improved emulsifying agent, specific preparation process comprises the following steps：
Solid lipid is heated first（65~90℃）Melt, then add lecithin, heating stirring adds auxiliary to homogeneous
Emulsifying agent, heating（65~90℃）Stirring to being down to room temperature in the lump.
Embodiment 2
A kind of improved emulsifying agent, is calculated by mass percentage, and its raw material composition and content are as follows：
Lecithin 45%；
Coemulsifier 5%；
Solid lipid 50%；
Described lecithin be hydrolecithin and soybean lecithin by mass percentage, i.e. hydrolecithin:Egg yolk lecithin
For 4:The mixture of 1 composition；
Described coemulsifier is dehydration sorbic alcohol stearate；
Described solid lipid is aliphatic alcohols（16 carbon alcohol, octadecanol, two Lauryl Alcohols）By mass percentage, i.e., ten six
Carbon alcohol：Octadecanol：Two Lauryl Alcohols are 2:2:The mixture of 1 composition；
A kind of above-mentioned improved emulsifying agent, specific preparation process comprises the following steps：
Solid lipid is heated first（65~90℃）Melt, then add lecithin, heating stirring adds auxiliary to homogeneous
Emulsifying agent, heating（65~90℃）Stirring to being down to room temperature in the lump.
Embodiment 3
A kind of improved emulsifying agent, is calculated by mass percentage, and its raw material composition and content are as follows：
Lecithin 15%
Coemulsifier 20%
Solid lipid 65%
Described lecithin be hydrolecithin and egg yolk lecithin by mass percentage, i.e. hydrolecithin：Soybean lecithin
For 4:The mixture of 1 composition；
Described coemulsifier be dehydration sorbic alcohol oleate and polyoxyethylene sorbitan sorbic alcohol oleate in mass ratio, that is, lose
Water sorbic alcohol oleate：Polyoxyethylene sorbitan sorbic alcohol oleate is 1:The mixture of 1 composition；
Described solid lipid is aliphatic alcohols（Octadecanol）, glyceride（Glycerin monostearate）And steroids（Plant steroid
Alcohol）By mass percentage, i.e. octadecanol：Glycerin monostearate：Phytosterol is 1:1:The mixture of 1 composition；
A kind of above-mentioned improved emulsifying agent, specific preparation process comprises the following steps：
Solid lipid is heated first（65~90℃）Melt, then add lecithin, heating stirring adds auxiliary to homogeneous
Emulsifying agent, heating（65~90℃）Stirring to being down to room temperature in the lump.
In summary, the emulsifying agent of a modification of the present invention, its preparation method is simple, contains liquid crystal structure available for preparing
Emulsion.
The above is only the basic explanation under present inventive concept, and according to technical scheme made it is any etc.
Effect conversion, all should belong to protection scope of the present invention.
Claims (2)
1. a kind of improved emulsifying agent, it is characterised in that：Calculate by mass percentage, its raw material composition and content are as follows：
Lecithin 5-45%；
Coemulsifier 5-30%；
Solid lipid 30-70%；
Described lecithin is one or both of soybean lecithin, egg yolk lecithin, hydrolecithin, hydroxylated lecithin
Combination above；
Described coemulsifier is ceteareth -25, ceteareth -6, ceteareth -12, whale
Wax stereth -20, ceteareth -30, stereth -2, stereth -21, dehydration sorbic alcohol oleic acid
Ester, dehydration sorbic alcohol stearate, dehydration sorbic alcohol laurate, polyoxyethylene sorbitan sorbic alcohol oleate, polyoxyethylene lose
The double oleic acid of water sorbic alcohol stearate, polyoxyethylene sorbitan sorbic alcohol laurate, PEG-20 tribehenins acid glyceride, PEG-8
The double stearates of ester, PEG-8, PEG-4 laurates, PEG-8 oleates, PEG-8 stearates, PEG-8 beeswaxs, PEG-20 are hard
Resin acid ester or PEG-32 stearates, Cremophor RH40, PEG-20 octadecyl alcolols ether, 16 stearyl alcohols and 16
Eight APGs, 16 stearyl alcohols and coconut alkyl glucosides, 16 stearyl alcohols and eicosyl glucoside, C14-
Combinations more than one or both of 22 alkylols etc.；
Described solid lipid is saturated fat acids, aliphatic alcohols, steroid, glyceride type, wax class, hydrogenated castor
Combination more than one or both of oil, the hard ester alcohol of spermaceti, hard ester alcohol, pentaerythritol stearic acid ester 2.
2. a kind of preparation method of improved emulsifying agent described in claim 1, it is characterised in that：It is first according to mass percent
Weigh lecithin, coemulsifier and solid lipid；Then solid lipid is heated to 65 ~ 90 DEG C of thawings, adds lecithin,
Heating stirring is eventually adding coemulsifier to homogeneous, is heated to 65 ~ 90 DEG C, and stirring to being down to room temperature in the lump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710437802.2A CN107308019A (en) | 2017-06-12 | 2017-06-12 | A kind of improved emulsifying agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710437802.2A CN107308019A (en) | 2017-06-12 | 2017-06-12 | A kind of improved emulsifying agent and preparation method thereof |
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| CN107308019A true CN107308019A (en) | 2017-11-03 |
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| CN201710437802.2A Pending CN107308019A (en) | 2017-06-12 | 2017-06-12 | A kind of improved emulsifying agent and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108113940A (en) * | 2017-12-29 | 2018-06-05 | 广州慈康生物科技有限公司 | A kind of frivolous moist type lotion and preparation method thereof |
| CN108126374A (en) * | 2017-12-25 | 2018-06-08 | 西安三业精细化工有限责任公司 | A kind of higher alcohols lotion antifoaming agent and preparation method for field of liquid crystals |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229354A (en) * | 1996-08-21 | 1999-09-22 | 普罗克特和甘保尔公司 | Skin lightening composition |
| CN101953759A (en) * | 2010-09-09 | 2011-01-26 | 江苏隆力奇生物科技股份有限公司 | Cosmetic composition |
| CN103202772A (en) * | 2013-01-17 | 2013-07-17 | 广州环亚化妆品科技有限公司 | Cream composition with stable liquid crystal structure and preparation method thereof |
| CN103494714A (en) * | 2013-10-16 | 2014-01-08 | 广东轻工职业技术学院 | Emulsifier composition capable of forming liquid crystal structure and application of emulsifier composition |
-
2017
- 2017-06-12 CN CN201710437802.2A patent/CN107308019A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229354A (en) * | 1996-08-21 | 1999-09-22 | 普罗克特和甘保尔公司 | Skin lightening composition |
| CN101953759A (en) * | 2010-09-09 | 2011-01-26 | 江苏隆力奇生物科技股份有限公司 | Cosmetic composition |
| CN103202772A (en) * | 2013-01-17 | 2013-07-17 | 广州环亚化妆品科技有限公司 | Cream composition with stable liquid crystal structure and preparation method thereof |
| CN103494714A (en) * | 2013-10-16 | 2014-01-08 | 广东轻工职业技术学院 | Emulsifier composition capable of forming liquid crystal structure and application of emulsifier composition |
Non-Patent Citations (1)
| Title |
|---|
| 裘炳毅: "《化妆品化学与工艺技术大全》", 31 January 2000, 中国轻工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108126374A (en) * | 2017-12-25 | 2018-06-08 | 西安三业精细化工有限责任公司 | A kind of higher alcohols lotion antifoaming agent and preparation method for field of liquid crystals |
| CN108113940A (en) * | 2017-12-29 | 2018-06-05 | 广州慈康生物科技有限公司 | A kind of frivolous moist type lotion and preparation method thereof |
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Application publication date: 20171103 |