CN110604311A - Electrolyte composite liquid preparation and preparation method thereof - Google Patents
Electrolyte composite liquid preparation and preparation method thereof Download PDFInfo
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- CN110604311A CN110604311A CN201911048219.8A CN201911048219A CN110604311A CN 110604311 A CN110604311 A CN 110604311A CN 201911048219 A CN201911048219 A CN 201911048219A CN 110604311 A CN110604311 A CN 110604311A
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- composite liquid
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- sucralose
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- 239000003792 electrolyte Substances 0.000 title claims abstract description 77
- 238000002360 preparation method Methods 0.000 title claims abstract description 64
- 239000007788 liquid Substances 0.000 title claims abstract description 51
- 239000002131 composite material Substances 0.000 title claims abstract description 49
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 60
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000004376 Sucralose Substances 0.000 claims abstract description 30
- 229960004543 anhydrous citric acid Drugs 0.000 claims abstract description 30
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 30
- 235000019408 sucralose Nutrition 0.000 claims abstract description 30
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims abstract description 29
- 239000011670 zinc gluconate Substances 0.000 claims abstract description 29
- 235000011478 zinc gluconate Nutrition 0.000 claims abstract description 29
- 229960000306 zinc gluconate Drugs 0.000 claims abstract description 29
- 239000001103 potassium chloride Substances 0.000 claims abstract description 28
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 28
- 239000008213 purified water Substances 0.000 claims abstract description 28
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 20
- 229960001031 glucose Drugs 0.000 claims abstract description 20
- 239000001509 sodium citrate Substances 0.000 claims abstract description 20
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 17
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 7
- 239000011259 mixed solution Substances 0.000 claims description 24
- 230000001954 sterilising effect Effects 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 18
- 239000012669 liquid formulation Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 9
- 229910021641 deionized water Inorganic materials 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 3
- 235000013305 food Nutrition 0.000 abstract description 4
- 229960002816 potassium chloride Drugs 0.000 abstract 2
- 229960001790 sodium citrate Drugs 0.000 abstract 1
- 235000011083 sodium citrates Nutrition 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 24
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 239000004202 carbamide Substances 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 235000013361 beverage Nutrition 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 210000002977 intracellular fluid Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides an electrolyte composite liquid preparation and a preparation method thereof, relating to the field of food and the field of special food, and the electrolyte composite liquid preparation provided by the invention comprises the following components: anhydrous glucose, edible salt, sodium citrate, zinc gluconate, potassium chloride, anhydrous citric acid, sucralose and purified water; the invention optimizes the formula of the electrolyte composite liquid preparation, and can quickly restore the balance of the electrolyte and the pH value of a human body and quickly relieve fatigue by adjusting the proportion of potassium chloride, zinc gluconate and anhydrous citric acid to sucralose, and has better mouthfeel. The invention also provides a preparation method of the electrolyte composite liquid preparation, which is simpler in process and saves a large amount of time and cost.
Description
The technical field is as follows:
the invention relates to the field of special foods and foods, in particular to an electrolyte composite liquid preparation and a preparation method thereof.
Background art:
water and electrolytes are components of life-supporting substances and are main components constituting body fluids. The water can not be separated during the metabolism process of the human body. Through the regulation of nerves and body fluid, the electrolyte and acid-base in normal body fluid are always in a dynamic balance state, and the capacities, electrolyte concentration, pH value, osmotic pressure and the like of intracellular fluid and extracellular fluid can be ensured to be always maintained in a certain range. Electrolytes include sodium ions, potassium ions, calcium ions, magnesium ions, etc., wherein sodium ions are important ions for maintaining the balance of extracellular fluid capacity and osmotic pressure. Along with the proposition of national fitness and the popularization of sports fitness, more and more people take the sports fitness as daily activities, and in the process of sports, the electrolyte content and water of a human body are continuously consumed along with the sports. Especially in hot summer, the temperature rise also causes a great deal of sweat secretion and water and electrolyte loss. Under various water shortage states, in order to improve the water shortage condition of the body, adjust the electrolyte and acid-base balance of the human body and avoid the occurrence of dehydration, an electrolyte liquid preparation needs to be supplemented at proper time to help regulate the body state. However, the electrolyte beverage in the market has single component or low content of electrolyte, can only temporarily solve thirst, and is not a plurality of beverages capable of achieving ideal water and electrolyte supplement.
The invention content is as follows:
in order to solve the technical problems, the invention provides an electrolyte composite liquid preparation and a preparation method thereof, and the prepared electrolyte composite liquid preparation can supplement body moisture, quickly adjust the balance of electrolyte and acid-base of a human body, quickly relieve fatigue and has no side effect after long-term use; the preparation method of the invention has simpler process, and the electrolyte composite liquid preparation is colorless and transparent and has good taste.
The invention provides an electrolyte composite liquid preparation, which comprises the following components in part by weight: 2-5g of anhydrous glucose, 1200mg of edible salt, 400mg of sodium citrate, 10-50mg of zinc gluconate, 200mg of potassium chloride, 200mg of anhydrous citric acid, 20-80mg of sucralose and 250mL of purified water.
Preferably, the electrolyte composite liquid preparation comprises: 2-4g of anhydrous glucose, 800mg of edible salt, 600mg of sodium citrate, 10-30mg of zinc gluconate, 200mg of potassium chloride, 600mg of anhydrous citric acid, 20-60mg of sucralose and 250mL of purified water.
Further preferably, the electrolyte composite liquid preparation comprises: 2.4g of anhydrous glucose, 520mg of edible salt, 580mg of sodium citrate, 13mg of zinc gluconate, 300mg of potassium chloride, 300mg of anhydrous citric acid, 20mg of sucralose and 196mL of purified water;
preferably, the weight ratio of the potassium chloride to the zinc gluconate is 10-50: 1; further preferably, the weight ratio of potassium chloride to zinc gluconate is 300: 13.
Preferably, the weight ratio of the anhydrous citric acid to the sucralose is 5-20: 1; further preferably, the weight ratio of the anhydrous citric acid to the sucralose is 15: 1.
In another aspect of the present invention, there is provided a method for preparing the above electrolyte composite liquid preparation, the method comprising the steps of:
(1) heating purified water to boil for 5 min, and cooling to 60-80 deg.C to obtain purified water A;
(2) mixing anhydrous glucose, edible salt, zinc gluconate, potassium chloride and sucralose, and uniformly stirring at room temperature to obtain a mixture A;
(3) adding the purified water A obtained in the step (1) into the mixture A obtained in the step (2), and stirring for 30-60 minutes at the temperature of 60-80 ℃ to obtain a mixed solution A;
(4) cooling the mixed solution A obtained in the step (3) to 30-40 ℃, adding sodium citrate and anhydrous citric acid to adjust the pH value to 4.0-4.5, and obtaining mixed solution B;
(5) and (4) filtering the mixed solution B obtained in the step (4), sterilizing at high temperature, subpackaging, sterilizing, cooling to room temperature and packaging.
Preferably, the high-temperature sterilization in the step (5) is carried out under the conditions that the sterilization temperature is 115-121 ℃ and the sterilization time is 15-30 minutes.
The liquid preparation can also be prepared according to the following preparation method:
(1) adding glucose, edible salt, sodium citrate, potassium chloride and anhydrous citric acid into deionized water, and completely dissolving to obtain a solution A;
(2) adding zinc gluconate and sucralose into deionized water, and completely dissolving to obtain a solution B;
(3) adding the solution B into the solution A, mixing uniformly, adding deionized water, mixing uniformly, filtering, filling, and sterilizing at high temperature to obtain a liquid preparation.
The invention has the beneficial effects that:
(1) the invention provides an electrolyte composite liquid preparation and a preparation method thereof, and the provided electrolyte composite liquid preparation can supplement body moisture, quickly adjust the balance of electrolyte and acid-base of a human body and quickly relieve fatigue, has good taste and no side effect after long-term use.
(2) The electrolyte composite liquid preparation formula is optimized, and the ratio of potassium chloride to zinc gluconate is adjusted, so that the absorption and utilization of the electrolyte composite liquid preparation by a human body are accelerated, the electrolyte and the pH value of the human body can be quickly restored to be balanced, and the fatigue is quickly relieved; in addition, the proportion of the anhydrous citric acid and the sucralose is adjusted, so that the electrolyte composite liquid preparation has better taste.
(3) The preparation method provided by the invention has simpler process and saves a large amount of time and cost.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In the following examples, each raw material was a commercially available product and was commercially available.
Example 1
An electrolyte composite liquid formulation comprising: 2g of anhydrous glucose, 300mg of edible salt, 400mg of sodium citrate, 10mg of zinc gluconate, 200mg of potassium chloride, 200mg of anhydrous citric acid, 20mg of sucralose and 150mL of purified water.
The preparation method of the electrolyte composite liquid preparation comprises the following steps:
(1) heating purified water to boil for 5 minutes, and cooling to 60 ℃ to obtain purified water A;
(2) mixing anhydrous glucose, edible salt, zinc gluconate, potassium chloride and sucralose, and uniformly stirring at room temperature to obtain a mixture A;
(3) adding the purified water A obtained in the step (1) into the mixture A obtained in the step (2), and stirring for 30 minutes at 60 ℃ to obtain a mixed solution A;
(4) cooling the mixed solution A obtained in the step (3) to 30 ℃, adding sodium citrate and anhydrous citric acid to adjust the pH value to 4.5, and obtaining mixed solution B;
(5) filtering the mixed solution B obtained in the step (4) by a 0.45-micron filter membrane, sterilizing for 30 minutes at 115 ℃, subpackaging, sterilizing, cooling to room temperature and packaging.
Example 2
An electrolyte composite liquid formulation comprising: 2.4g of anhydrous glucose, 520mg of edible salt, 580mg of sodium citrate, 13mg of zinc gluconate, 300mg of potassium chloride, 300mg of anhydrous citric acid, 20mg of sucralose and 196mL of purified water.
The preparation method of the electrolyte composite liquid preparation comprises the following steps:
(1) heating and boiling purified water for 5 minutes, and cooling to 70 ℃ to obtain purified water A;
(2) mixing anhydrous glucose, edible salt, zinc gluconate, potassium chloride and sucralose, and uniformly stirring at room temperature to obtain a mixture A;
(3) adding the purified water A obtained in the step (1) into the mixture A obtained in the step (2), and stirring for 40 minutes at 70 ℃ to obtain a mixed solution A;
(4) cooling the mixed solution A obtained in the step (3) to 35 ℃, adding sodium citrate and anhydrous citric acid to adjust the pH value to 3.9, and obtaining mixed solution B;
(5) filtering the mixed solution B obtained in the step (4) by a 0.45-micron filter membrane, sterilizing at the high temperature of 121 ℃ for 15 minutes, subpackaging, sterilizing, cooling to room temperature and packaging.
Example 3
An electrolyte composite liquid formulation comprising: 5g of anhydrous glucose, 1200mg of edible salt, 1000mg of sodium citrate, 50mg of zinc gluconate, 800mg of potassium chloride, 800mg of anhydrous citric acid, 80mg of sucralose and 250mL of purified water.
The preparation method of the electrolyte composite liquid preparation comprises the following steps:
(1) heating purified water to boil for 5 minutes, and cooling to 80 ℃ to obtain purified water A;
(2) mixing anhydrous glucose, edible salt, zinc gluconate, potassium chloride and sucralose, and stirring uniformly at room temperature to obtain a mixture A;
(3) adding the purified water A obtained in the step (1) into the mixture A obtained in the step (2), and stirring for 60 minutes at 80 ℃ to obtain a mixed solution A;
(4) cooling the mixed solution A obtained in the step (3) to 40 ℃, adding sodium citrate and anhydrous citric acid to adjust the pH value to 4.2, and obtaining mixed solution B;
(5) filtering the mixed solution B obtained in the step (4) by a 0.45-micron filter membrane, sterilizing at the high temperature of 121 ℃ for 18 minutes, subpackaging, sterilizing, cooling to room temperature and packaging.
Example 4
An electrolyte composite liquid preparation comprises 4g of anhydrous glucose, 800mg of edible salt, 1000mg of sodium citrate, 30mg of zinc gluconate, 600mg of potassium chloride, 600mg of anhydrous citric acid, 60mg of sucralose and 250mL of purified water.
The preparation method of the electrolyte composite liquid preparation comprises the following steps:
(1) heating and boiling purified water for 5 minutes, and cooling to 72 ℃ to obtain purified water A;
(2) mixing anhydrous glucose, edible salt, zinc gluconate, potassium chloride and sucralose, and uniformly stirring at room temperature to obtain a mixture A;
(3) adding the purified water A obtained in the step (1) into the mixture A obtained in the step (2), and stirring for 35 minutes at 72 ℃ to obtain a mixed solution A;
(4) cooling the mixed solution A obtained in the step (3) to 30 ℃, adding sodium citrate and anhydrous citric acid to adjust the pH value to 4.0, and obtaining mixed solution B;
(5) filtering the mixed solution B obtained in the step (4) by a 0.45-micron filter membrane, sterilizing at the high temperature of 121 ℃ for 15 minutes, subpackaging, sterilizing, cooling to room temperature and packaging.
Example 5
An electrolyte composite liquid preparation and a method for preparing the same, which differ from example 2 only in that 200mg of potassium chloride, 20mg of zinc gluconate; namely the weight ratio of potassium chloride to zinc gluconate is 10: 1.
Example 6
An electrolyte composite liquid preparation and a method for preparing the same, which differ from example 2 only in that 500mg of potassium chloride, 10mg of zinc gluconate; i.e. the weight ratio of potassium chloride to zinc gluconate is 50: 1.
Example 7
An electrolyte complex liquid preparation and a method for preparing the same, which are different from example 2 only in that 250mg of anhydrous citric acid, 50mg of sucralose; i.e. the weight ratio of anhydrous citric acid to sucralose is 5: 1.
Example 8
An electrolyte complex liquid preparation and a method for preparing the same, which are different from example 2 only in that 500mg of anhydrous citric acid, 25mg of sucralose; i.e., the weight ratio of anhydrous citric acid to sucralose is 20: 1.
The liquid preparation of the above embodiment can also be prepared by the following method:
(1) adding glucose, edible salt, sodium citrate, potassium chloride and anhydrous citric acid into deionized water, and completely dissolving to obtain a solution A;
(2) adding zinc gluconate and sucralose into deionized water, and completely dissolving to obtain a solution B;
(3) adding the solution B into the solution A, mixing uniformly, adding deionized water, mixing uniformly, filtering, filling, and sterilizing at high temperature to obtain a liquid preparation.
Comparative example 1
An electrolyte composite liquid preparation and a method for preparing the same, which are different from example 5 only in that zinc gluconate is not added.
Comparative example 2
An electrolyte composite liquid preparation and a method for preparing the same, which are different from example 5 only in that sucralose is not added.
Comparative example 3
An electrolyte complex liquid preparation and a method for preparing the same, which are different from example 5 only in that sodium citrate and anhydrous citric acid are not added and pH is not adjusted.
Comparative example 4
Chinese patent CN108419962A discloses a functional liquid preparation formula for regulating electrolyte, and the specific formula is example 2 of the patent.
Experimental example 1
The test method comprises the following steps: 130 aerobic sportsmen who were fond of walking were recruited and were healthy, the test subjects were aged 18 to 25 years, male and female were not limited, and were divided into two groups at random, test group and control group, respectively, and the test groups were divided at random into 12 groups by taking the electrolyte liquid formulations described in examples 1 to 8 and comparative examples 1 to 4, and 10 persons were each group of 12 test groups and control groups. The test was run for 1 hour each day, and the test group was asked to drink 200mL of the electrolyte liquid preparation described in examples 1 to 8 and comparative examples 1 to 4 10min after the exercise was finished, and the control group was asked to drink an equal amount of water and continued the training for 30 days, during which the subjects did not take any electrolyte liquid preparation.
The detection method comprises the following steps: the contents of blood sugar, blood sodium, blood potassium, blood lactic acid and Blood Urea (BU) of a subject in three stages of before exercise (stage one), after exercise without taking an electrolyte liquid preparation (stage two) and after taking the electrolyte liquid preparation for 20min (stage three) are detected once every 10 days, the detection results of the same person in the same stage are counted, and the average value is calculated.
Table 1: three-phase blood glucose concentration changes
| Group of | Stage one (mmol/L) | Stage two (mmol/L) | Stage three (mmol/L) |
| Example 1 | 4.95 | 4.58 | 5.21 |
| Example 2 | 4.33 | 4.24 | 4.84 |
| Example 3 | 4.78 | 4.22 | 4.89 |
| Example 4 | 4.20 | 3.89 | 4.73 |
| Example 5 | 4.64 | 4.01 | 4.98 |
| Example 6 | 4.71 | 4.48 | 5.01 |
| Example 7 | 5.39 | 5.07 | 5.82 |
| Example 8 | 5.18 | 4.57 | 5.59 |
| Comparative example 1 | 4.62 | 4.10 | 4.47 |
| Comparative example 2 | 5.56 | 4.95 | 5.08 |
| Comparative example 3 | 5.77 | 5.04 | 5.16 |
| Comparative example 4 | 4.29 | 4.01 | 4.22 |
| Control group | 4.66 | 4.04 | 4.18 |
As can be seen from table 1, the electrolyte composite liquid formulations prepared in examples 1 to 8 according to the present invention can rapidly replenish glycogen and restore physical strength, particularly the electrolyte composite liquid formulation described in example 2, compared to the electrolyte composite liquid formulation prepared in the comparative example.
Table 2: three-stage change in blood sodium concentration
Table 3: three-stage change in blood potassium concentration
| Group of | Stage one (mmol/L) | Stage two (mmol/L) | Stage three (mmol/L) |
| Example 1 | 4.18 | 3.74 | 4.54 |
| Example 2 | 3.99 | 3.52 | 4.38 |
| Example 3 | 4.24 | 3.78 | 4.50 |
| Example 4 | 4.20 | 3.82 | 4.44 |
| Example 5 | 3.62 | 3.30 | 3.90 |
| Example 6 | 4.22 | 3.64 | 4.71 |
| Example 7 | 4.24 | 3.75 | 4.61 |
| Example 8 | 3.74 | 3.25 | 4.22 |
| Comparative example 1 | 4.14 | 3.64 | 3.70 |
| Comparative example 2 | 4.08 | 3.56 | 3.73 |
| Comparative example 3 | 4.47 | 3.89 | 4.20 |
| Comparative example 4 | 4.66 | 4.05 | 4.38 |
| Control group | 4.32 | 3.89 | 3.64 |
As can be seen from tables 2 and 3, the electrolyte composite liquid formulations prepared in examples 1 to 8 according to the present invention can rapidly adjust the electrolytes of the human body to rapidly restore the electrolytes to an equilibrium state, compared to the electrolyte composite liquid formulation prepared in the comparative example, particularly the electrolyte composite liquid formulation described in example 2.
Table 4: three-stage blood lactate concentration changes
| Group of | Stage one (mmol/L) | Stage two (mmol/L) | Stage three (mmol/L) |
| Example 1 | 0.64 | 1.57 | 1.01 |
| Example 2 | 0.86 | 1.81 | 1.16 |
| Example 3 | 0.56 | 1.47 | 0.89 |
| Example 4 | 0.76 | 1.59 | 0.90 |
| Example 5 | 0.67 | 1.62 | 1.02 |
| Example 6 | 0.91 | 1.81 | 1.24 |
| Example 7 | 0.74 | 1.68 | 0.94 |
| Example 8 | 0.94 | 1.86 | 1.28 |
| Comparative example 1 | 0.66 | 1.62 | 1.39 |
| Comparative example 2 | 0.72 | 1.67 | 1.36 |
| Comparative example3 | 0.74 | 1.65 | 1.29 |
| Comparative example 4 | 1.03 | 1.94 | 1.48 |
| Control group | 0.97 | 1.92 | 1.96 |
As can be seen from Table 4, after exercise, the blood lactic acid content of human body is rapidly increased, after drinking the electrolyte composite liquid preparation provided by the invention, the blood lactic acid concentration in human body can be rapidly reduced, after the exercise amount is increased, the blood lactic acid recovery speed can be accelerated, and the aerobic exercise capacity can be improved.
Table 5: three-stage Blood Urea (BU) concentration change
| Group of | Stage one (mmol/L) | Stage two (mmol/L) | Stage three (mmol/L) |
| Example 1 | 6.96 | 7.92 | 7.44 |
| Example 2 | 7.28 | 8.17 | 7.69 |
| Example 3 | 6.58 | 7.46 | 6.89 |
| Example 4 | 7.31 | 8.24 | 7.47 |
| Example 5 | 6.99 | 7.88 | 7.34 |
| Example 6 | 7.25 | 8.19 | 7.50 |
| Example 7 | 7.16 | 8.15 | 7.57 |
| Example 8 | 7.39 | 8.20 | 7.64 |
| Comparative example 1 | 6.76 | 7.66 | 7.62 |
| Comparative example 2 | 7.04 | 8.05 | 7.96 |
| Comparative example 3 | 6.84 | 7.79 | 7.60 |
| Comparative example 4 | 7.11 | 8.02 | 7.85 |
| Control group | 6.93 | 7.83 | 7.65 |
As can be seen from Table 5, the blood urea content of human body increases after exercise, and the blood urea concentration decreases after drinking the electrolyte composite liquid preparation provided by the present invention, demonstrating that the electrolyte beverage can rapidly relieve fatigue.
Experimental example 2
The satisfaction degree of the taste and the effect of the electrolyte composite liquid preparation provided by the invention is investigated, and the volunteers are 120 persons in the experimental example 1. The satisfaction can be divided into: very satisfactory, general, unsatisfactory, very unsatisfactory.
Table 6: survey of degree of satisfaction of taste
As can be seen from table 6, the addition of sucralose and anhydrous citric acid in the formulation can affect the mouthfeel of the electrolyte composite liquid preparation provided by the invention, and the mouthfeel of the electrolyte composite liquid preparation is better and more popular by optimizing the formulation; in addition, the electrolyte composite liquid preparation provided by the invention is a colorless transparent liquid.
The foregoing is a preferred embodiment of the present invention, and is not intended to limit the invention in any way, so that any simple modification and equivalent changes made to the above embodiment without departing from the technical spirit of the present invention are considered to be within the scope of the present invention.
Claims (7)
1. An electrolyte composite liquid preparation, comprising: 2-5g of anhydrous glucose, 1200mg of edible salt, 400mg of sodium citrate, 10-50mg of zinc gluconate, 200mg of potassium chloride, 200mg of anhydrous citric acid, 20-80mg of sucralose and 250mL of purified water.
2. The electrolyte composite liquid formulation of claim 1, wherein the electrolyte composite liquid formulation comprises: 2-4g of anhydrous glucose, 800mg of edible salt, 600mg of sodium citrate, 10-30mg of zinc gluconate, 200mg of potassium chloride, 600mg of anhydrous citric acid, 20-60mg of sucralose and 250mL of purified water.
3. The electrolyte composite liquid preparation according to claim 2, wherein the weight ratio of potassium chloride to zinc gluconate is 10-50: 1.
4. The electrolyte complex liquid formulation of claim 2, wherein the weight ratio of the anhydrous citric acid to the sucralose is 5-20: 1.
5. A method of preparing the electrolyte composite liquid formulation according to any one of claims 1 to 4, wherein the method comprises the steps of:
(1) heating purified water to boil for 5 min, and cooling to 60-80 deg.C to obtain purified water A;
(2) mixing anhydrous glucose, edible salt, zinc gluconate, potassium chloride and sucralose, and uniformly stirring at room temperature to obtain a mixture A;
(3) adding the purified water A obtained in the step (1) into the mixture A obtained in the step (2), and stirring for 30-60 minutes at the temperature of 60-80 ℃ to obtain a mixed solution A;
(4) cooling the mixed solution A obtained in the step (3) to 30-40 ℃, adding sodium citrate and anhydrous citric acid to adjust the pH value to 4.0-4.5 to obtain a mixed solution B;
(5) and (4) filtering the mixed solution B obtained in the step (4), sterilizing at high temperature, subpackaging, cooling to room temperature and packaging.
6. The method according to claim 5, wherein the conditions for the high-temperature sterilization in the step (5) are a sterilization temperature of 115 ℃ to 121 ℃ and a sterilization time of 15 to 30 minutes.
7. An electrolyte composite liquid formulation according to any one of claims 1 to 4, wherein the liquid formulation is prepared by:
(1) adding glucose, edible salt, sodium citrate, potassium chloride and anhydrous citric acid into deionized water, and completely dissolving to obtain a solution A;
(2) adding zinc gluconate and sucralose into deionized water, and completely dissolving to obtain a solution B;
(3) adding the solution B into the solution A, mixing uniformly, adding deionized water, mixing uniformly, filtering, filling, and sterilizing at high temperature to obtain a liquid preparation.
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| CN116420880A (en) * | 2023-04-25 | 2023-07-14 | 贵州金玖生物技术有限公司 | Preparation method of colorless and transparent electrolyte formula liquid food containing glucose |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104664534A (en) * | 2015-03-25 | 2015-06-03 | 威海爱威制药有限公司 | Electrolyte beverage and production process thereof |
| CN105998056A (en) * | 2016-05-12 | 2016-10-12 | 江苏正大丰海制药有限公司 | Orally-taken glucose electrolyte composition |
| CN109044966A (en) * | 2018-09-21 | 2018-12-21 | 辽宁康博士制药有限公司 | A kind of glucose oral solution and preparation method thereof, application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104664534A (en) * | 2015-03-25 | 2015-06-03 | 威海爱威制药有限公司 | Electrolyte beverage and production process thereof |
| CN105998056A (en) * | 2016-05-12 | 2016-10-12 | 江苏正大丰海制药有限公司 | Orally-taken glucose electrolyte composition |
| CN109044966A (en) * | 2018-09-21 | 2018-12-21 | 辽宁康博士制药有限公司 | A kind of glucose oral solution and preparation method thereof, application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116420880A (en) * | 2023-04-25 | 2023-07-14 | 贵州金玖生物技术有限公司 | Preparation method of colorless and transparent electrolyte formula liquid food containing glucose |
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