CN110596377A - Dry-type immunochromatography diagnosis device based on microfluid - Google Patents
Dry-type immunochromatography diagnosis device based on microfluid Download PDFInfo
- Publication number
- CN110596377A CN110596377A CN201910704954.3A CN201910704954A CN110596377A CN 110596377 A CN110596377 A CN 110596377A CN 201910704954 A CN201910704954 A CN 201910704954A CN 110596377 A CN110596377 A CN 110596377A
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- collecting
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- diagnostic device
- module
- microfluidic
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- 238000003745 diagnosis Methods 0.000 title abstract description 9
- 238000003317 immunochromatography Methods 0.000 title description 5
- 238000001514 detection method Methods 0.000 claims abstract description 96
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 55
- 239000012528 membrane Substances 0.000 claims abstract description 17
- 239000003085 diluting agent Substances 0.000 claims abstract description 15
- 239000000020 Nitrocellulose Substances 0.000 claims abstract description 13
- 229920001220 nitrocellulos Polymers 0.000 claims abstract description 13
- 239000002250 absorbent Substances 0.000 claims abstract description 9
- 230000002745 absorbent Effects 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 3
- 210000000601 blood cell Anatomy 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000010586 diagram Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
Abstract
The invention relates to the technical field of biology, in particular to a dry-type immunochromatographic diagnosis device based on microfluid. A dry-type immunochromatographic diagnostic device based on microfluid comprises a collection module, a reagent detection module and a cap for protecting the collection module and storing a sample diluent; the collecting module comprises a collecting part body, a collecting pipeline part and a collecting end part are arranged in the collecting part body, and the collecting module comprises at least one collecting part body; the reagent detection module comprises a reagent detection body, at least one detection part is arranged in the reagent detection body, and the detection part comprises a sample pad, a marking pad, a nitrocellulose membrane, absorbent paper and a bottom plate; the bottom plate is arranged at the bottom of the detection part, and the sample pad, the marking pad, the nitrocellulose membrane and the absorbent paper are sequentially and horizontally arranged on the bottom plate; the reagent detection module is connected with the acquisition module.
Description
Technical Field
The invention relates to the technical field of biology, in particular to a dry-type immunochromatographic diagnosis device based on microfluid.
Background
With the continuous development and progress of science and technology, the medical detection technology is continuously updated. Among them, immunochromatography is a new detection technique emerging from foreign countries. The principle of immunochromatography is as follows: fixing a specific antibody on a certain part of the nitrocellulose membrane, moving the solution to be detected on the nitrocellulose membrane when the solution to be detected contacts with the dried nitrocellulose membrane, and dyeing the binding region section when the solution to be detected contacts with the specific antibody on the nitrocellulose membrane, for example, dyeing with immune colloidal gold or immune enzyme can make the binding region show a certain color, thereby carrying out specific immune diagnosis.
The existing detection tool is often set as a detection card or a kit, and although the related technology has been developed to a certain extent with the scientific progress, the existing dry-type immunochromatography diagnosis device or kit still has certain problems: the detection that current detection device often gathered sample and sample is gone on step by step, gathers the sample with the help of gathering the instrument earlier promptly, stores or places somewhere, and reagent test card or similar product of later taking out detect, and such operation process is complicated, the error rate is high and detection efficiency is low, and the sample is only gathered once to the single collection, or the single collection can only detect the single, in the face of the big condition of detection volume, the unable problem that is suitable for of traditional device.
Disclosure of Invention
The invention provides a dry-type immunochromatographic diagnosis device based on microfluid, which aims to solve the problems of complex operation process, high error rate, low detection efficiency and limited applicable scene of the existing device.
The invention relates to a dry-type immunochromatographic diagnosis device based on microfluid, which adopts the following technical scheme:
a dry-type immunochromatographic diagnosis device based on microfluid comprises an acquisition module and a reagent detection module;
the collecting module is used for collecting detection reagents and comprises a collecting part body, a collecting pipeline part and a collecting end part are arranged in the collecting part body and are used for circulating samples or sample diluent, and the collecting module comprises at least one collecting part body;
the reagent detection module comprises a reagent detection body, wherein at least one detection part is arranged in the reagent detection body, and the detection part comprises a sample pad, a marking pad, a nitrocellulose membrane, absorbent paper and a bottom plate; wherein the bottom plate is arranged at the bottom of the detection part, and the sample pad, the marking pad, the nitrocellulose membrane and the absorbent paper are sequentially and horizontally arranged on the bottom plate;
the reagent detection module is connected with the acquisition module;
and the cap is provided with a storage cavity for storing the sample diluent.
The reagent detection body and the collection body are assembled in a split mode, and the collection body is arranged at a port of the reagent detection body.
The collecting end part comprises a sampling inlet, the collecting inlet is connected with the collecting pipeline part, the collecting pipeline part comprises at least one capillary pipeline cavity, the sectional area of a front port of the capillary pipeline cavity, which is connected with the sampling inlet, is smaller than that of a tail port of the capillary pipeline cavity, and the capillary pipeline cavities are in one-to-one correspondence with the detection parts.
One side surface of the tail port of the capillary pipeline cavity protrudes outwards to form a sample accumulation pool.
The collecting pipeline part is connected with the detection part.
The sample pad is inserted into the capillary channel cavity to promote the collected liquid to flow into the sample pad, and the detection part also comprises a blood filtering membrane for filtering blood cells.
A rotating shaft groove is formed in the inner side wall of the cap, and the collecting part body is connected with the rotating shaft groove through a rotating shaft.
The inner side wall of the cap is correspondingly provided with two sliding grooves, a moving part is arranged between the two sliding grooves, the moving part slides in the sliding grooves along the extending direction of the inner side wall of the cap, an inner pipeline is arranged in the middle of the moving part, and one end, close to the storage cavity, of the inner pipeline is provided with a sharp opening, so that the sharp opening end of the moving part can be inserted into the storage cavity under the pushing of the collecting body.
The reagent detection body comprises an upper cover and a lower cover, wherein a pressing part is arranged on the inner side of the upper cover, a non-closed groove is formed in the lower cover, and the detection part is arranged in the groove.
The position department that the upper cover corresponds the sample pad be provided with the trompil that is used for pouring into the diluent, the upper cover with the lower cover between be provided with hasp and lock post and be connected.
The surface of the upper cover and the surface of the lower cover are provided with anti-skidding grooves, and the side surfaces of the upper cover and the lower cover are provided with clamping grooves.
The invention has the beneficial effects that: the device comprises a collecting module, a reagent detecting module and a sample collecting device, wherein the collecting module is used for collecting samples, the set reagent detecting module is used for detecting collected samples, the collecting module comprises at least one collecting body, one or more collecting bodies are arranged according to the detection requirement, the samples are detected simultaneously, the samples can be detected simultaneously from the same type of samples and also from different types of samples, and the application range is greatly improved. The set reagent detection module comprises a reagent detection body, a detection part is arranged in the reagent detection body, and at least one detection part is arranged. The position of the detection part corresponds to the position of the acquisition part body one by one, so that the integrity of the whole structure is ensured. The collection module and the reagent detection module can be integrally formed or combined in different modules. In the process, the single collecting piece body is an independent whole, and the plurality of collecting piece bodies cannot influence each other when the number of the collecting piece bodies is increased, so that the collecting efficiency is improved, the collecting accuracy is improved, and the interference is prevented; the single reagent detection body is also an independent whole, and when the number of the reagent detection bodies is increased, the plurality of reagent detection bodies cannot influence each other, so that the detection accuracy is improved while the detection efficiency is improved, and the interference is prevented.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic external view of a first embodiment of a dry micro-fluidic-based immunochromatographic diagnostic device according to the present invention;
FIG. 2 is a schematic view of the internal structure of FIG. 1;
FIG. 3 is a schematic structural diagram of the detecting unit in FIG. 2;
FIG. 4 is a schematic structural view of the upper cover in FIG. 1;
FIG. 5 is a schematic structural view of the lower cover of FIG. 1;
FIG. 6 is a schematic structural diagram of a second embodiment of a microfluidic-based dry immunochromatographic diagnostic device of the present invention;
FIG. 7 is a schematic structural diagram of a third embodiment of a microfluidic-based dry immunochromatographic diagnostic device of the present invention;
FIG. 8 is a schematic structural diagram of a fourth embodiment of a dry micro-fluidic-based immunochromatographic diagnostic device of the present invention;
FIG. 9 is a schematic structural diagram of a fifth embodiment of a microfluidic-based dry immunochromatographic diagnostic device of the present invention;
FIG. 10 is a schematic diagram of a microfluidic-based dry immunochromatographic diagnostic device according to a sixth embodiment of the present invention, using a diluent;
FIG. 11 is a schematic view of the sample collection structure of FIG. 10;
FIG. 12 is a schematic diagram of a microfluidic-based dry immunochromatographic diagnostic device according to a seventh embodiment of the present invention, using a diluent;
FIG. 13 is a schematic structural diagram of an eighth embodiment of a microfluidic-based dry immunochromatographic diagnostic device of the present invention;
FIG. 14 is a schematic view of the detecting part shown in FIG. 13;
in the figure: 1. an acquisition module; 2. a collection member body; 201. a sampling inlet; 3. a reagent detection module; 4. A reagent detection body; 41. an upper cover; 42. a lower cover; 5. a clamping groove; 6. an anti-slip groove; 7. opening a hole; 8. a sample pad; 9. a marking pad; 10. a nitrocellulose membrane; 11. absorbent paper; 12. a capillary channel cavity; 13. a base plate; 14. a blood filtration membrane; 15. a cover; 151. a storage cavity; 16. locking; 17. a lock cylinder; 18. a groove; 19. a pressing part; 20. an observation window; 21. a rotating shaft; 22. a rotating shaft groove; 23. a sliding groove; 24. a movable member; 25. an inner pipeline.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the first embodiment of the microfluidic-based dry immunochromatographic diagnostic device of the present invention, as shown in fig. 1 to 5, a microfluidic-based dry immunochromatographic diagnostic device includes an acquisition module 1 and a reagent detection module 3; the collection module 1 is sealed with a lid 15.
The collecting module 1 is used for collecting detection reagents, the collecting module 1 comprises a collecting part body 2, a collecting pipeline part and a collecting end part which are used for circulating samples or sample diluent are arranged in the collecting part body 2, and the collecting module 1 comprises at least one collecting part body 2;
further, the reagent detection module 3 comprises a reagent detection body 4, at least one detection part is arranged in the reagent detection body 4, and the detection part comprises a sample pad 8, a marking pad 9, a nitrocellulose membrane 10, absorbent paper 11 and a bottom plate 13; wherein the bottom plate 13 is arranged at the bottom of the detection part, and the sample pad 8, the marking pad 9, the nitrocellulose membrane 10 and the absorbent paper 11 are sequentially and horizontally arranged on the bottom plate 13;
further, the reagent detection module 3 is connected with the collection module 4.
Further, a storage cavity 151 for storing a sample diluent is formed in the cap.
Furthermore, the reagent detection body 4 and the collection body 2 are assembled in a split manner.
Further, gather the tip and include sampling inlet 201, collection inlet 201 with collection pipeline portion 12 be connected, collection pipeline portion include at least one capillary duct chamber 12, the cross sectional area of the preceding port in capillary duct chamber 12 that capillary duct chamber 12 and sampling inlet 201 are connected is less than the cross sectional area of the afterbody port in capillary duct chamber, capillary duct chamber with detection portion one-to-one.
Furthermore, one side surface of the tail port of the capillary channel cavity protrudes outwards to form a sample accumulation pool.
Further, the collecting pipeline part 12 is connected with the detecting part.
Furthermore, a capillary plug-in unit with a sharp opening at one end is sleeved on the sample pad 8, and the sharp opening of the capillary plug-in unit extends into the capillary channel cavity.
Further, the reagent detecting body 4 comprises an upper cover 41 and a lower cover 42, wherein the inner side of the upper cover 41 is provided with a pressing part 19, the lower cover 42 is provided with a non-closed groove 18, and the detecting part is arranged in the groove 18.
Furthermore, an opening 7 for injecting a diluent is disposed at a position of the upper cover 41 corresponding to the sample pad, and a lock 16 and a lock column 17 are disposed between the upper cover 41 and the lower cover 42 for connection.
Furthermore, the surfaces of the upper cover 41 and the lower cover 42 are provided with anti-skid grooves 6, and the sides of the upper cover 41 and the lower cover 42 are provided with clamping grooves 5.
Further, the upper cover 41 is provided with an observation window 20 for observing the detection process.
The invention has the beneficial effects that: the device comprises a collecting module, a reagent detecting module and a sample collecting device, wherein the collecting module is used for collecting samples, the set reagent detecting module is used for detecting collected samples, the collecting module comprises at least one collecting body, one or more collecting bodies are arranged according to the detection requirement, the samples are detected simultaneously, the samples can be detected simultaneously from the same type of samples and also from different types of samples, and the application range is greatly improved. The set reagent detection module comprises a reagent detection body, a detection part is arranged in the reagent detection body, and at least one detection part is arranged. The position of the detection part corresponds to the position of the acquisition part body one by one, so that the integrity of the whole structure is ensured. The collection module and the reagent detection module can be integrally formed or combined in different modules. In the process, the single collecting piece body is an independent whole, and the plurality of collecting piece bodies cannot influence each other when the number of the collecting piece bodies is increased, so that the collecting efficiency is improved, the collecting accuracy is improved, and the interference is prevented; the single reagent detection body is also an independent whole, and when the number of the reagent detection bodies is increased, the plurality of reagent detection bodies cannot influence each other, so that the detection accuracy is improved while the detection efficiency is improved, and the interference is prevented.
In the second embodiment of the microfluidic dry immunochromatographic diagnostic device of the present invention, as shown in fig. 6, the sample pad 8 is inserted into the capillary channel cavity to facilitate the inflow of the collected liquid to the sample pad 8, and the detection part further includes a blood filtration membrane 14 for filtering blood cells.
In the third embodiment of the dry immunochromatographic diagnostic device based on microfluid of the present invention, as shown in fig. 7, the present embodiment employs three collecting element bodies 2 and three detection portions, and the three collecting element bodies 2 are integrally designed.
In the fourth embodiment of the dry immunochromatographic diagnostic device based on microfluid according to the present invention, as shown in fig. 8, the present invention employs two collecting member bodies 2 and two detecting portions, and the collecting member bodies 2 are designed to be separated.
In the fifth embodiment of the dry immunochromatographic diagnostic device based on microfluid according to the present invention, as shown in fig. 9, a single collection member body 2 is adopted, two capillary channel cavities 12 are provided in the single collection member body 2, and the detection part is provided for separation.
In a sixth embodiment of the dry immunochromatographic diagnostic device based on microfluid according to the present invention, as shown in fig. 10 and 11, a rotating shaft groove 22 is formed in an inner sidewall of a cap, and the collecting element body 2 is connected to the rotating shaft groove 22 through a rotating shaft 21, so that the collecting element body 2 can be turned over to collect a sample, as shown in fig. 11. The body of the acquisition member may also be inverted to absorb the diluent, as shown in figure 10.
In a seventh embodiment of the dry immunochromatographic diagnostic device based on microfluid of the present invention, as shown in fig. 12, two sliding grooves 23 are correspondingly formed in the inner side wall of the cap, a movable member 24 is disposed between the two sliding grooves, and the movable member 24 slides in the sliding grooves 23 along the extending direction of the inner side wall of the cap. An inner pipe is arranged in the middle of the movable member 24, and one end of the inner pipe, which is close to the storage cavity, is provided with a sharp opening and can be inserted into the storage cavity 151. An inner conduit is provided for the flow of diluent in the storage cavity 151 to the collection module.
In an eighth embodiment of the dry immunochromatographic diagnostic device based on microfluid according to the present invention, as shown in fig. 13 and 14, two symmetrical detection parts are disposed in a reagent detection body 4, wherein a bottom plate is an integral body, a collection module includes two collection member bodies 2, the two collection member bodies 2 are disposed at two ends of the reagent detection body 4, and the device can detect two samples simultaneously. Set up like this, can make full use of reagent detect the space of body for the efficiency of detection. The rest of the scheme is the same as the first embodiment.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. A dry immunochromatographic diagnostic device based on microfluidics, characterized in that: comprises an acquisition module, a reagent detection module and a cap for protecting the acquisition module and storing a sample diluent;
the collecting module is used for collecting detection reagents and comprises a collecting part body, a collecting pipeline part and a collecting end part are arranged in the collecting part body and are used for circulating samples or sample diluent, and the collecting module comprises at least one collecting part body;
the reagent detection module comprises a reagent detection body, wherein at least one detection part is arranged in the reagent detection body, and the detection part comprises a sample pad, a marking pad, a nitrocellulose membrane, absorbent paper and a bottom plate; wherein the bottom plate is arranged at the bottom of the detection part, and the sample pad, the marking pad, the nitrocellulose membrane and the absorbent paper are sequentially and horizontally arranged on the bottom plate;
the reagent detection module is connected with the acquisition module;
and the cap is provided with a storage cavity for storing the sample diluent.
2. The microfluidic-based dry immunochromatographic diagnostic device according to claim 1, wherein: the reagent detection body and the collection body are assembled in a split mode, and the collection body is arranged at a port of the reagent detection body.
3. The microfluidic-based dry immunochromatographic diagnostic device according to claim 2, wherein: the collecting end part comprises a sampling inlet, the collecting inlet is connected with the collecting pipeline part, the collecting pipeline part comprises at least one capillary pipeline cavity, the sectional area of a front port of the capillary pipeline cavity, which is connected with the sampling inlet, is smaller than or equal to the sectional area of a tail port of the capillary pipeline cavity, and the capillary pipeline cavities are in one-to-one correspondence with the detection parts.
4. The microfluidic-based dry immunochromatographic diagnostic device according to claim 3, wherein: one side surface of the tail port of the capillary pipeline cavity protrudes outwards to form a sample accumulation pool.
5. The microfluidic-based dry immunochromatographic diagnostic device according to claim 4, wherein: the collecting pipeline part is connected with the detection part.
6. The microfluidic-based dry immunochromatographic diagnostic device according to claim 5, wherein: the sample pad is inserted into the capillary channel cavity to promote the collected liquid to flow into the sample pad, and the detection part also comprises a blood filtering membrane for filtering blood cells.
7. The microfluidic-based dry immunochromatographic diagnostic device according to claim 6, wherein: the inner side wall of the cap is correspondingly provided with two sliding grooves, a moving part is arranged between the two sliding grooves, the moving part slides in the sliding grooves along the extending direction of the inner side wall of the cap, an inner pipeline is arranged in the middle of the moving part, and one end, close to the storage cavity, of the inner pipeline is provided with a sharp opening, so that the sharp opening end of the moving part can be inserted into the storage cavity under the pushing of the collecting body.
8. The microfluidic-based dry immunochromatographic diagnostic device according to claim 6, wherein: a rotating shaft groove is formed in the inner side wall of the cap, and the collecting part body is connected with the rotating shaft groove through a rotating shaft.
9. The microfluidic-based dry immunochromatographic diagnostic device according to claim 7 or 8, wherein: the reagent detection body comprises an upper cover and a lower cover, wherein a pressing part is arranged on the inner side of the upper cover, a non-closed groove is formed in the lower cover, and the detection part is arranged in the groove; the position department that the upper cover corresponds the sample pad be provided with the trompil that is used for pouring into the diluent, the upper cover with the lower cover between be provided with hasp and lock post and be connected.
10. The microfluidic-based dry immunochromatographic diagnostic device according to claim 9, wherein: the surface of the upper cover and the surface of the lower cover are provided with anti-skidding grooves, and the side surfaces of the upper cover and the lower cover are provided with clamping grooves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910704954.3A CN110596377A (en) | 2019-08-01 | 2019-08-01 | Dry-type immunochromatography diagnosis device based on microfluid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910704954.3A CN110596377A (en) | 2019-08-01 | 2019-08-01 | Dry-type immunochromatography diagnosis device based on microfluid |
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| CN110596377A true CN110596377A (en) | 2019-12-20 |
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| CN201910704954.3A Pending CN110596377A (en) | 2019-08-01 | 2019-08-01 | Dry-type immunochromatography diagnosis device based on microfluid |
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