CN110584713B - Super-resolution ultrasonic microscope - Google Patents
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Abstract
The invention relates to the technical field of ultrasonic imaging, and provides a super-resolution ultrasonic microscopic device which comprises a planar ultrasonic transducer, an acoustic artificial structure and an imaging device. The transmitting end of the planar ultrasonic transducer transmits ultrasonic sound wave signals with a certain frequency, the ultrasonic sound waves are diffracted after passing through the acoustic artificial structure, an ultrasonic diffraction limit focusing sound field area is formed on one side, far away from the planar ultrasonic transducer, of the acoustic artificial structure along the transmission direction of the ultrasonic sound waves, the ultrasonic sound waves blocked by an object to be imaged in the ultrasonic diffraction limit focusing sound field area are reflected to the planar ultrasonic transducer and received, finally, the received signals are transmitted to an imaging device for ultrasonic imaging, and the resolution of an imaging image is higher.
Description
Technical Field
The invention relates to the technical field of ultrasonic imaging, in particular to a super-resolution ultrasonic microscopic device.
Background
Ultrasound, a mechanical wave, is generated by the vibration of an object (acoustic source) and caused to propagate through a medium that compresses and expands. In addition to the general properties of waves, ultrasound has an important feature that attenuation in human tissues such as water and muscle is small, and the ultrasound can reach deeper human tissues. The interaction of medical ultrasonic waves and human tissues mainly applies the basic physical characteristics of the interaction of sound waves and substances, has three major acoustic effects such as fluctuation effect, mechanical effect and thermal effect, and has important application or great potential in biomedicine. Traditional ultrasound has been developed to have two basic functions of imaging diagnosis and thermal ablation therapy based on the wave effect and thermal effect. The fluctuation effect can be used for ultrasonic imaging diagnosis technologies with very wide clinical application such as B-ultrasonic, color ultrasonic, radiography and the like; thermal effects can be used for thermal ablation of tumors and for the treatment of nerve core mass destruction, such as high intensity focused ultrasound.
Ultrasonic imaging, especially B-ultrasonic imaging, has been used as a main detection method for human organ diagnosis, and with the rapid development of ultrasound, ultrasonic imaging such as internal diameter ultrasound, contrast ultrasound, three-dimensional imaging, elastography, etc. has been rapidly developed on the basis of B-ultrasonic imaging. The B-ultrasonic imaging is performed by using a conventional curved ultrasonic transducer or by using a convex acoustic lens in combination with a planar ultrasonic transducer. And because the classical wave has the limit of diffraction limit, the limit is difficult to break to realize super resolution under general conditions. Therefore, the resolution of ultrasonic imaging is not very high, and the microstructure and the form of human tissues cannot be distinguished.
Disclosure of Invention
The invention aims to provide a super-resolution ultrasonic microscopic device and application thereof, and aims to solve the problem of low imaging resolution of the existing ultrasonic imaging equipment.
In order to achieve the purpose, the invention adopts the technical scheme that: the super-resolution ultrasonic microscopic device comprises a planar ultrasonic transducer for transmitting ultrasonic sound wave signals, an acoustic artificial structure member which is positioned at the transmitting end of the planar ultrasonic transducer and used for regulating and controlling the ultrasonic diffraction limit focusing of the sound waves, and an imaging device for receiving imaging reflection signals of the planar ultrasonic transducer, wherein the ultrasonic sound waves form an ultrasonic diffraction limit focusing sound field area for imaging an object to be imaged after passing through the acoustic artificial structure member.
In one embodiment, the acoustic artificial structure is a closed circular cylinder connected end to end, and the middle part of the circular cylinder is provided with a first diffraction channel for ultrasonic sound waves to pass through for focusing a sound field with super-diffraction limit.
In one embodiment, the circular diameter range of the circular cylinder is greater than or equal to 4 λ and less than or equal to 12 λ, where λ is the wavelength of the ultrasonic sound wave.
In one embodiment, the cylinder diameter of the circular cylinder ranges from 0.2 λ or more to 6 λ or less.
In one embodiment, the material of the circular cylinder is any one of resin, rubber and polymethyl methacrylate.
In one embodiment, the acoustic artificial structure is a sheet-shaped cylinder, and a second diffraction channel for ultrasonic sound waves to pass through for super-diffraction limit focusing of the sound field is formed in the middle of the sheet-shaped cylinder.
In one embodiment, the diameter range of the sheet-shaped cylinder is greater than or equal to 2.4 λ and less than or equal to 12 λ, wherein λ is the wavelength of the ultrasonic sound wave.
In one embodiment, the diameter of the second diffraction channel ranges from 0.4 λ or more to 10 λ or less.
In one embodiment, the thickness of the sheet-like pillars ranges from 0.2 λ or more to λ or less.
In one embodiment, the sheet-like pillar is made of any one of resin, rubber, and polymethyl methacrylate.
In one embodiment, the emission frequency range of the planar ultrasonic transducer is 0.2 MHz-100 MHz.
In one embodiment, the focused focal spot of the sound wave in the super-diffraction limit focused sound field area is less than or equal to 0.61 λ, wherein λ is the wavelength of the ultrasonic sound wave.
In one embodiment, the super-resolution ultrasound microscopy apparatus further comprises a needle-type ultrasound probe disposed along the ultrasound wave propagation direction and within the super-diffraction-limit focused acoustic field region.
In a second aspect, an application of the super-resolution ultrasonic microscopy device is provided, and the super-resolution ultrasonic microscopy device is applied to super-resolution imaging.
In one embodiment, the size of the object for super-resolution imaging of the super-resolution ultrasonic microscopy device is less than or equal to 0.61 lambda, wherein lambda is the wavelength of the ultrasonic sound wave.
The invention has the beneficial effects that: the super-resolution ultrasonic microscope device provided by the invention has the following working principle: the transmitting end of the planar ultrasonic transducer transmits ultrasonic sound wave signals with a certain frequency, the ultrasonic sound waves are diffracted after passing through the acoustic artificial structure, an ultrasonic diffraction limit focusing sound field area is formed on one side, far away from the planar ultrasonic transducer, of the acoustic artificial structure along the transmission direction of the ultrasonic sound waves, the ultrasonic sound waves are blocked by an object to be imaged and reflected to the planar ultrasonic transducer and received in the ultrasonic diffraction limit focusing sound field area, finally, the received signals are transmitted to an imaging device for ultrasonic imaging, and an imaging image with higher resolution ratio is obtained.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.
FIG. 1 is a schematic structural diagram of a super-resolution ultrasound microscopy apparatus provided in an embodiment of the present application;
FIG. 2 is a cross-sectional view of an acoustic artificial structure of a super-resolution ultrasound microscopy apparatus provided in an embodiment of the present application;
fig. 3 is a schematic structural diagram of an acoustic artificial structure of a super-resolution ultrasound microscopy apparatus according to another embodiment of the present application.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, and are used merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Referring to fig. 1, the super-resolution ultrasound microscopy apparatus provided in the embodiment of the present application includes a planar ultrasound transducer 10 for emitting an ultrasound acoustic signal, an acoustic artificial structure 20 located at an emitting end of the planar ultrasound transducer 10 for adjusting and controlling an ultrasonic diffraction limit focus of the acoustic wave, and an imaging apparatus 30 for receiving an imaging reflection signal of the planar ultrasound transducer 10. The ultrasonic sound waves pass through the acoustic artificial structure 20 to form a super-diffraction-limited focused sound field region 40 for imaging an object to be imaged.
The super-resolution ultrasonic microscopic device provided by the embodiment of the application has the working principle as follows: the transmitting end of the planar ultrasonic transducer 10 transmits an ultrasonic sound wave signal with a certain frequency, the ultrasonic sound wave is diffracted after passing through the acoustic artificial structure 20, an ultra-diffraction limit focusing sound field area 40 is formed on one side of the acoustic artificial structure 20 away from the planar ultrasonic transducer 10 along the transmission direction of the ultrasonic sound wave after the acoustic artificial structure 20, the ultrasonic sound wave blocked by an object to be imaged in the ultra-diffraction limit focusing sound field area 40 is reflected to the planar ultrasonic transducer 10 and received, finally, the received signal is transmitted to the imaging device 30 for ultrasonic imaging, and an imaging image with higher resolution is obtained.
Referring to fig. 1 and 2, in one embodiment, the acoustic artificial structure 20 is a circular cylinder connected end to end and closed, and the middle of the circular cylinder has a first diffraction channel 20a for ultrasonic sound waves to pass through for focusing the sound field at the super-diffraction limit. It will be appreciated that the annular cylinder is a closed annular structure formed by connecting a cylindrical rod end to end and having the first diffractive channel 20a in the middle. The ultrasonic sound wave emitted from the emitting end of the planar ultrasonic transducer 10 is diffracted at the first diffraction channel 20a, and forms an ultra-diffraction limited focused sound field region 40.
The generation of the super-diffraction-limited focused acoustic field region 40 requires the following conditions to be satisfied: the annular diameter D1 of the annular cylinder is in the range of 4 λ or more and 12 λ or less. It is understood that the circular diameter D1 of the circular cylinder may be 4 λ, 4.5 λ, 5 λ, 5.5 λ, 6 λ, 6.5 λ, 7 λ, 7.5 λ, 8 λ, 8.5 λ, 9 λ, 9.5 λ, 10 λ, 10.5 λ, 11 λ, 11.5 λ, and 12 λ. The cylindrical diameter d1 of the circular cylindrical body is in the range of 0.2 lambda or more and 6 lambda or less. The cylinder diameter d1 of the circular ring cylinder may be 0.2 λ, 0.4 λ, 0.6 λ, 0.8 λ, 1, 1.2 λ, 1.4 λ, 1.6 λ, 1.8 λ, 2 λ, 2.2 λ, 2.4 λ, 2.6 λ, 2.8 λ, 3 λ, 3.2 λ, 3.4 λ, 3.6 λ, 3.8 λ, 4 λ, 4.2 λ, 4.4 λ, 4.6 λ, 4.8 λ, 5 λ, 5.2 λ, 5.4 λ, 5.6 λ, 5.8 λ, and 6 λ. Wherein λ is the wavelength of the ultrasonic sound wave. The inner diameter of the first diffraction channel 20a is limited by the ring diameter D1 and the column diameter D1 which define the ring column. And, the emission frequency range of the planar ultrasonic transducer 10 is 0.2MHz to 100 MHz. It is understood that the emission frequency of the planar ultrasonic transducer 10 may be 0.2MHz, 1MHz, 2MHz, 5MHz, 10MHz, 15MHz, 20MHz, 25MHz, 30MHz, 35MHz, 40MHz, 45MHz, 50MHz, 55MHz, 60MHz, 65MHz, 70MHz, 75MHz, 80MHz, 85MHz, 90MHz, 95MHz, and 100 MHz. The material of the circular cylinder is any one of resin, rubber and polymethyl methacrylate.
In one embodiment, the emission frequency of the planar ultrasonic transducer 10 is 1MHz, the wavelength of the ultrasonic sound wave is λ 1.5mm, the material of the circular cylinder is photosensitive resin, the circular diameter D1 of the circular cylinder is 9mm, the cylinder diameter D1 of the circular cylinder is 3.6mm, that is, the inner diameter of the first diffraction channel 20a is 1.8 mm.
Referring to fig. 1 and 3, in another embodiment, the acoustic artificial structure 20 is a sheet-shaped cylinder, and a second diffraction channel 20b for allowing the ultrasonic sound wave to pass through for super-diffraction limit focusing of the sound field is formed in the middle of the sheet-shaped cylinder. It is understood that the super-diffraction limit focused acoustic field region 40 can also be formed when the ultrasonic sound wave passes through the second diffraction channel 20b of the sheet cylinder.
The following conditions need to be satisfied for generating the super-diffraction-limited focused acoustic field region 40: the diameter D2 of the sheet column is in the range of 2.4 lambda or more and 12 lambda or less. It is understood that the diameter D2 of the plate cylinder may be 2.4 λ, 2.6 λ, 2.8 λ, 3 λ, 3.2 λ, 3.4 λ, 3.6 λ, 3.8 λ, 4 λ, 4.2 λ, 4.4 λ, 4.6 λ, 4.8 λ, 5 λ, 5.2 λ, 5.4 λ, 5.6 λ, 5.8 λ, 6 λ, 6.2 λ, 6.4 λ, 6.8 λ, 7 λ, 7.2 λ, 7.4 λ, 7.6 λ, 7.8 λ, 8 λ, 8.2 λ, 8.4 λ, 8.6 λ, 8.8 λ, 9 λ, 9.2 λ, 9.4 λ, 9.6 λ, 9.8 λ, 10 λ, 10.2 λ, 10.4 λ, 10.6 λ, 10.8 λ, 11 λ, 11.2 λ, 11.4 λ, 11.6 λ, 11.8 λ, 11.2 λ, 11.12 λ and 12 λ. The diameter range of the second diffraction channel 20b is 0.4 λ or more and 10 λ or less. It is understood that the second diffraction channel 20b has a diameter of 0.4 λ, 0.6 λ, 0.8 λ, 1.2 λ, 1.6 λ, 1.8 λ, 2 λ, 2.2 λ, 2.4 λ, 2.6 λ, 2.8 λ, 3 λ, 3.2 λ, 3.4 λ, 3.6 λ, 3.8 λ, 4 λ, 4.2 λ, 4.4 λ, 4.6 λ, 4.8 λ, 5 λ, 5.2 λ, 5.4 λ, 5.6 λ, 5.8 λ, 6 λ, 6.2 λ, 6.4 λ, 6.8 λ, 7 λ, 7.2 λ, 7.4 λ, 7.6 λ, 7.8 λ, 8.2 λ, 8.4 λ, 8.6 λ, 8.8 λ, 9 λ, 9.2 λ, 9.4 λ, 9.6 λ, 9.8 λ, and 10.10 λ. The thickness range of the sheet-like column is 0.2 λ or more and λ or less. It is understood that the thickness of the sheet-shaped pillars is 0.2 λ, 0.3 λ, 0.4 λ, 0.5 λ, 0.6 λ, 0.7 λ, 0.8 λ, 0.9 λ, and λ. The sheet-like column is made of any one of resin, rubber, and polymethyl methacrylate.
In one embodiment, the emission frequency of the planar ultrasonic transducer 10 is 1MHz, the wavelength of the ultrasonic sound wave is λ 1.5mm, the material of the sheet-shaped cylinder is photosensitive resin, the diameter D2 of the sheet-shaped cylinder is 10.2mm, the inner diameter of the annular first diffraction channel 20a is 0.6mm, and the thickness of the sheet-shaped cylinder is 0.6 mm.
In one embodiment, the focused focal spot of the acoustic wave in the super-diffraction limited focused acoustic field region 40 is less than or equal to 0.61 λ, where λ is the wavelength of the ultrasonic acoustic wave. Here, the super-diffraction limit imaging is imaging of an object having a size of 0.61 times or less wavelength. That is, when the size of the object to be imaged is less than 0.61 λ, the conventional ultrasonic imaging apparatus cannot realize high-resolution imaging.
Referring to fig. 1, in an embodiment, the super-resolution ultrasound microscopy apparatus further includes a needle-type ultrasound probe 50, wherein the needle-type ultrasound probe 50 is disposed along the propagation direction of the ultrasound wave and is disposed in the super-diffraction limit focusing acoustic field region 40. The needle-type ultrasonic detector 50 is used for receiving the ultrasonic sound wave penetrating through the object to be imaged to realize transmission-type ultrasonic imaging, that is, the super-resolution ultrasonic microscopic device can select an imaging mode according to the imaging requirement.
The application also provides an application of the super-resolution ultrasonic microscopic device, and the super-resolution ultrasonic microscopic device is applied to super-resolution imaging. That is, the ultra-diffraction limit focusing of the ultrasonic waves is realized by the acoustic artificial structure 20, and the ultra-resolution imaging of the object can be performed by using the ultra-diffraction limit focusing sound field. The method is particularly suitable for carrying out super-resolution imaging on the micro structure of the human tissue which cannot be resolved.
In one embodiment, the size of the object for super-resolution imaging of the super-resolution ultrasound microscopy device is less than or equal to 0.61 λ, wherein λ is the wavelength of the ultrasound wave.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (3)
1. A super-resolution ultrasonic microscopic device is characterized by comprising a planar ultrasonic transducer for emitting ultrasonic sound wave signals, an acoustic artificial structure member which is positioned on one side of an emitting end of the planar ultrasonic transducer and used for regulating and controlling ultrasonic diffraction limit focusing of sound waves, and an imaging device for receiving imaging reflection signals of the planar ultrasonic transducer, wherein ultrasonic sound waves form an ultrasonic diffraction limit focusing sound field area for imaging an object to be imaged on one side of the acoustic artificial structure member away from the planar ultrasonic transducer after passing through the acoustic artificial structure member; the acoustic artificial structural part is a circular cylinder which is formed by connecting a columnar rod body end to form a closed circular structure, the middle part of the circular cylinder is provided with a first diffraction channel for ultrasonic sound waves to pass through for super-diffraction limit focusing sound field, the inner diameter of the first diffraction channel is firstly reduced and then increased along the ultrasonic sound wave emission direction, and the inner wall of the first diffraction channel is arc-shaped; the diameter range of the circular ring cylinder is greater than or equal to 4 lambda and less than or equal to 12 lambda, wherein lambda is the wavelength of ultrasonic sound waves, and the diameter range of the circular ring cylinder is greater than or equal to 0.2 lambda and less than or equal to 6 lambda.
2. The super-resolution ultrasound microscopy apparatus according to claim 1, wherein the focused focal spot of the sound wave in the super-diffraction limited focused sound field region is equal to or less than 0.61 λ, where λ is the wavelength of the ultrasound sound wave.
3. The super-resolution ultrasound microscopy apparatus according to claim 1, further comprising a needle-type ultrasound probe disposed along the ultrasound acoustic wave propagation direction and within the super-diffraction-limited focused acoustic field region.
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| CN113499096B (en) * | 2021-06-21 | 2022-10-25 | 西安交通大学 | Imaging platform and method for ultrasonic cross-scale and multi-parameter detection |
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| TWI263063B (en) * | 2004-12-31 | 2006-10-01 | Ind Tech Res Inst | A super-resolution optical component and a left-handed material thereof |
| KR101704584B1 (en) * | 2015-04-16 | 2017-02-22 | 포항공과대학교 산학협력단 | Microscopic apparatus for super-resolution imaging organisms or biomatter and method for super-resolution imaging organisms or biomatter using the same |
| KR101814425B1 (en) * | 2015-05-08 | 2018-01-03 | 포항공과대학교 산학협력단 | Super-resolution lens and microscopic apparatus comprising the same |
| WO2017176921A1 (en) * | 2016-04-05 | 2017-10-12 | President And Fellows Of Harvard College | Meta-lenses for sub-wavelength resolution imaging |
| CN106932916B (en) * | 2017-05-04 | 2019-10-01 | 鲁东大学 | A kind of dual-beam super-resolution focus method using Meta Materials lens |
| CN107644636A (en) * | 2017-09-01 | 2018-01-30 | 深圳先进技术研究院 | A kind of focus ultrasonic lens based on plane artificial structure |
| CN109102795B (en) * | 2018-09-21 | 2020-11-27 | 同济大学 | Acoustic super lens for realizing deep sub-wavelength imaging |
| CN109431543A (en) * | 2018-12-20 | 2019-03-08 | 深圳先进技术研究院 | Sound wave condenser lens, supersonic imaging device and method |
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| CN106782477A (en) * | 2016-12-16 | 2017-05-31 | 江苏大学 | A kind of Helmholtz chambers acoustic metamaterial with membrane structure |
| CN107589178A (en) * | 2017-08-15 | 2018-01-16 | 南京工业大学 | Method for realizing wave front regulation and control of sound waves by utilizing super-structure surface formed by Helmholtz resonators |
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