CN110575499A - A Chinese medicinal composition for preventing and treating mammary gland hyperplasia and lump, and its preparation method - Google Patents
A Chinese medicinal composition for preventing and treating mammary gland hyperplasia and lump, and its preparation method Download PDFInfo
- Publication number
- CN110575499A CN110575499A CN201910925572.3A CN201910925572A CN110575499A CN 110575499 A CN110575499 A CN 110575499A CN 201910925572 A CN201910925572 A CN 201910925572A CN 110575499 A CN110575499 A CN 110575499A
- Authority
- CN
- China
- Prior art keywords
- parts
- hyperplasia
- rhizoma
- peel
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese herbal medicine composition for preventing and treating breast hyperplasia and lumps, which is prepared from the following components in parts by weight: 50-70 parts of spina date seed, 70-90 parts of fingered citron, 90-110 parts of holboellia latifolia, 50-70 parts of dandelion, 50-70 parts of poria cocos, 50-70 parts of green tangerine peel (fried), 20-50 parts of ligusticum wallichii, 50-70 parts of rhizoma corydalis, 40-60 parts of rhizoma pleionis, 30-50 parts of cynanchum paniculatum and 160 parts of jujube peel 140-. The traditional Chinese medicine composition disclosed by the invention is composed of multiple natural Chinese herbal medicines, is reasonable in proportion, has no toxic or side effect, can directly act on mammary tissue, can improve blood circulation of the mammary tissue and dilate blood vessels, further prevents and treats hyperplasia and lumps of breasts, and enables breasts to be more body-building and stiff. In addition, the traditional Chinese medicine composition provided by the invention can reduce the occurrence of breast diseases after being used for a long time, and has a wide application prospect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a Chinese herbal medicine composition for preventing and treating breast hyperplasia and lumps and a preparation method thereof.
Background
The breast diseases are common diseases in clinic, and the traditional Chinese medicine has obvious and unique advantages and characteristics for treating the breast diseases. The understanding of the disease by traditional Chinese medicine is early, the traditional Chinese medicine documents of the past generations have abundant records on the physiology, pathology, etiology, pathogenesis, diagnosis, treatment, prevention nursing and the like of the breast, and especially since the construction of the country, many medical researchers apply the modern scientific technology to the clinical experiments and researches of the breast disease, thereby further enriching the academic research and theory of the traditional Chinese medicine for treating the breast, leading the breast to be continuously developed and perfected and achieving huge achievements and great development.
With the development of society, the thought pressure of people is greater and greater, and the incidence of breast diseases is also on the trend of increasing year by year. Western medicine has great side effects on the treatment of breast diseases and great harm to human bodies, and traditional Chinese medicine becomes one of the most important components with advantages and characteristics in the research on treating breast diseases because of non-toxic reaction, so the application aims to develop a Chinese herbal medicine composition capable of preventing and treating breast hyperplasia and lumps so as to expand the application range of treating breast diseases in traditional Chinese medicine.
Disclosure of Invention
The invention provides a Chinese herbal medicine composition for preventing and treating hyperplasia and lumps of breasts, which is used for widening the application range of treating breast diseases in traditional Chinese medicine.
The invention aims to provide a Chinese herbal medicine composition for preventing and treating hyperplasia and lumps of breasts, which is prepared from the following components in parts by weight:
50-70 parts of spina date seed, 70-90 parts of fingered citron, 90-110 parts of holboellia latifolia, 50-70 parts of dandelion, 50-70 parts of poria cocos, 50-70 parts of green tangerine peel (fried), 20-50 parts of ligusticum wallichii, 50-70 parts of rhizoma corydalis, 40-60 parts of rhizoma pleionis, 30-50 parts of cynanchum paniculatum and 160 parts of jujube peel 140-.
Preferably, the Chinese herbal medicine oral tablet capable of preventing and treating breast hyperplasia and lumps is prepared from the following components in parts by weight:
60 parts of spina date seed, 80 parts of fingered citron, 100 parts of holboellia latifolia, 60 parts of dandelion, 60 parts of poria cocos, 60 parts of green tangerine peel (fried), 30 parts of ligusticum wallichii, 60 parts of rhizoma corydalis, 50 parts of rhizoma pleionis, 40 parts of cynanchum paniculatum and 150 parts of jujube peel.
the second purpose of the invention is to provide a preparation method of the Chinese herbal medicine composition for preventing and treating breast hyperplasia and lumps, which comprises the following steps:
Step 1, weighing 50-70 parts of spina date seed, 70-90 parts of fingered citron, 90-110 parts of holboellia latifolia, 50-70 parts of dandelion, 50-70 parts of poria cocos, 50-70 parts of green tangerine peel (fried), 20-50 parts of ligusticum wallichii, 50-70 parts of rhizoma corydalis, 40-60 parts of bulb of pleione, 30-50 parts of cynanchum paniculatum and 160 parts of jujube peel 140 and other materials in parts by weight;
Step 2, mixing the spina Gleditsiae, fructus Citri Sarcodactylis, fructus Akebiae, herba Taraxaci, Poria, and pericarpium Citri Reticulatae viride (parched), adding 5 times of water, decocting at 65 deg.C for 30-60min, filtering, and collecting filtrate to obtain mixture A;
Mixing the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel weighed in the step 1, adding water which is 5 times of the total weight of the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel, decocting the mixture at 85 ℃ for 30-60min, filtering the decoction, and collecting filtrate to obtain a mixture B;
And uniformly mixing the mixture A and the mixture B, and then freeze-drying to obtain freeze-dried powder, namely the Chinese herbal medicine composition.
Preferably, the Chinese herbal medicine composition is an oral tablet.
Preferably, the freeze-drying process conditions are as follows: freeze drying at-30 deg.C for 3-5 hr to obtain the lyophilized powder.
The invention has the following advantages:
1. Tianding
The functional indications are as follows: disinfecting, expelling pus, dispelling wind and killing parasites. It is indicated for carbuncle, cellulitis, scrofula, skin sore, rash, intractable tinea, puerperal hypogalactia, retained placenta and leprosy.
The anticancer effect is as follows: (1) in vitro test, the hot water extract has JTC-26 inhibition rate of 50-70%. (2) In vivo experiment shows that it has inhibitory activity on turbid mouse sarcoma-180. The decoction can be used for inhibiting Staphylococcus aureus and Catalpa by punching holes on plate; the inhibition rate of 60g/kg of water infusion agent to the sarcoma-180 by intragastric administration is 32.8%.
2. Finger citron
The functional indications are as follows: regulate qi-flowing, resolve phlegm. It can be used for treating gastralgia, hypochondriac distention, emesis, dysphagia, phlegm retention, cough and asthma, and relieving hangover.
The pharmacological action is as follows: the alcohol extract has obvious inhibition effect on isolated rat intestinal tracts; the cat intravenous injection also has heart inhibiting and blood pressure lowering effects.
3. eight-month melon
the functional indications are as follows: scanty and brownish urine, stranguria with turbid urine, edema, rheumatalgia, traumatic injury, galactostasis, uterine prolapse, and orchitis.
4. dandelion
The functional indications are as follows: clearing away heat and toxic material, inducing diuresis and resolving hard mass. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
The pharmacological action is as follows: antibacterial, lactogenesis promoting, antitumor, and choleretic effects.
5. poria cocos (Schw.) wolf
The functional indications are as follows: can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
The pharmacological action is as follows: anti-tumor and detoxicating effects.
6. green tangerine peel
the functional indications are as follows: distending pain in chest and hypochondrium, hernia pain, nodules of breast, mammary abscess, food stagnation and qi stagnation, and abdominal pain.
The pharmacological action is as follows: eliminating phlegm, relieving asthma, treating smooth muscle, increasing blood pressure, and resisting shock.
7. ligusticum wallichii
The functional indications are as follows: pain due to blood stasis and qi stagnation, headache, and arthralgia due to wind-dampness.
The pharmacological action is as follows: ligustrazine can dilate coronary artery, increase coronary blood flow, improve myocardial blood oxygen supply, and reduce myocardial oxygen consumption; ligustrazine can dilate cerebral vessels, reduce vascular resistance, remarkably increase blood flow of brain and limbs, and improve microcirculation; can reduce the surface activity of blood platelet, inhibit blood platelet aggregation, and prevent thrombosis; the neutral component of the ferulic acid is promoted in a small dose, and the uterine smooth muscle is inhibited in a large dose; the water decoction has a sedative effect on the central nervous system of animals and has an obvious and lasting antihypertensive effect; can accelerate the absorption of local hematoma of fracture and promote the formation of callus; has effect in resisting vitamin E deficiency; can inhibit multiple bacilli; has antihistaminic and choleretic effects.
8. Rhizoma corydalis
The functional indications are as follows: pain due to qi stagnation and blood stasis, dysmenorrhea, amenorrhea, abdominal mass, puerperal stagnation, traumatic injury, and hernia.
The pharmacological action is as follows: animal experiments prove that the corydaline and the tetrahydropalmatine have analgesic effect, and the tetrahydropalmatine has higher analgesic index. Tetrahydropalmatine is inhibitory to both cortical and subcortical electrical activity, and is particularly sensitive to the cortical motor region. Dehydrocorydaline can protect experimental gastric ulcer of rat caused by hunger or injection of cortisone and reserpine, reduce gastric secretion, and reduce gastric acid and pepsin.
9. All-grass of Indian iphigenia
The functional indications are as follows: clearing away heat and toxic material, eliminating carbuncle and dissipating stagnation.
Chemical components: the rhizomes of Cremastra appendiculata Makino contain mucilage, glucomannan and mannose.
10. radix Cynanchi Paniculati
the functional indications are as follows: various pains such as rheumatism pain, lumbago, traumatic injury pain, abdominal pain, toothache and the like. The paniculate swallowwort root has good effects of dispelling wind and relieving pain, and is widely used for various pains caused by rheumatism, congealing cold, qi stagnation and blood stasis. Also can be used for postoperative pain and cancer pain, and has certain analgesic effect. It can be used singly or combined with herbs related to syndrome.
The pharmacological action is as follows: has effects in inhibiting bacteria and treating smooth muscle diseases.
11. Jujube peel
The functional indications are as follows: tonify liver and kidney, astringe essence and qi, and consolidate deficiency. It is used to treat soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, frequent micturition, liver deficiency, cold and heat, sweating, and heart shaking pulse powder. Tonify liver and kidney, astringe essence and relieve depletion. Can be used for treating vertigo, tinnitus, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, sweating, asthenia, internal heat, and diabetes. Warming liver and tonifying kidney, dispelling all wind, stopping menorrhagia, treating frequent micturition of the elderly.
The hyperplasia of breasts and lumps of breasts are called as nodules of breasts or lumps of breasts in traditional Chinese medicine, and the causes of the hyperplasia of breasts and lumps of breasts are emotional depression, discomfort of liver qi, long-term depression of qi, stagnation of qi and blood, phlegm reduction due to invasion and stagnation of phlegm and blood, so that hard and tough breast nodules are formed, and the breasts are swollen and painful, and are even dragged to the axillary chest. The breast hyperplasia and the lump can not be cured for a long time, and the risk of canceration can be caused.
The treatment method of breast hyperplasia and lump is mainly to soothe liver and regulate qi, activate blood and remove blood stasis, soften hard lumps and dissipate stagnation, and relieve swelling and pain. Based on the principle, 11 medicines are selected for compatibility, wherein the Tianding, the fingered citron and the holboellia latifolia are used for eliminating carbuncle, dissipating binds and relieving pain, the dandelion, the poria cocos and the green tangerine orange peel (fried) are used for soothing the liver, regulating qi and relieving depression, the dandelion, the poria cocos and the green tangerine orange peel are used as ministerial medicines, the ligusticum chuanxiong hort, the rhizoma corydalis, the rhizoma pleionis, the cynanchum paniculatum and the jujube peel are used for regulating qi and dredging collaterals, and the assistant medicines. The medicines are combined to play the roles of resolving carbuncle, dissipating stagnation, soothing liver, regulating qi, activating blood and dissolving stasis.
Compared with the prior art, the invention has the beneficial effects that:
The traditional Chinese medicine composition disclosed by the invention is composed of multiple natural Chinese herbal medicines, is reasonable in proportion, has no toxic or side effect, can directly act on mammary tissue, can improve blood circulation of the mammary tissue and dilate blood vessels, further prevents and treats hyperplasia and lumps of breasts, and enables breasts to be more body-building and stiff. In addition, the medicinal composition can reduce the occurrence of breast diseases after being used for a long time, and has wide application prospect.
Detailed Description
in order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
Example 1
A Chinese herbal medicine oral tablet capable of preventing and treating breast hyperplasia and lumps is prepared from the following raw materials in parts by weight: 60 parts of spina date seed, 80 parts of fingered citron, 100 parts of holboellia latifolia, 60 parts of dandelion, 60 parts of poria cocos, 60 parts of green tangerine peel (fried), 30 parts of ligusticum wallichii, 60 parts of rhizoma corydalis, 50 parts of rhizoma pleionis, 40 parts of cynanchum paniculatum and 150 parts of jujube peel.
The preparation method comprises the following steps:
Step 1, weighing 60 parts of spina date seed, 80 parts of fingered citron, 100 parts of holboellia latifolia, 60 parts of dandelion, 60 parts of poria cocos, 60 parts of green tangerine peel (fried), 30 parts of ligusticum wallichii, 60 parts of rhizoma corydalis, 50 parts of rhizoma pleionis, 40 parts of cynanchum paniculatum and 150 parts of jujube peel according to parts by weight;
Step 2, mixing the spina Gleditsiae, fructus Citri Sarcodactylis, fructus Akebiae, herba Taraxaci, Poria, and pericarpium Citri Reticulatae viride (parched), adding 5 times of water, decocting at 65 deg.C for 30min, filtering, and collecting filtrate to obtain mixture A;
Mixing the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel weighed in the step 1, adding water which is 5 times of the total weight of the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel, decocting the mixture at 85 ℃ for 30min, filtering the decoction, and collecting filtrate to obtain a mixture B;
Uniformly mixing the mixture A and the mixture B, freeze-drying at-30 ℃ for 3h to obtain freeze-dried powder, adding a proper amount of auxiliary materials into the freeze-dried powder, uniformly mixing, granulating, sieving, drying, further tabletting the prepared granules, and drying to obtain the Chinese herbal medicine oral tablet for preventing and treating hyperplasia of mammary glands and lumps.
example 2
A Chinese herbal medicine oral tablet capable of preventing and treating breast hyperplasia and lumps is prepared from the following raw materials in parts by weight: 50 parts of Chinese violet, 70 parts of finger citron, 90 parts of holboellia latifolia, 70 parts of dandelion, 50 parts of poria cocos, 50 parts of green tangerine peel (fried), 20 parts of ligusticum chuanxiong hort, 70 parts of rhizoma corydalis, 40 parts of rhizoma pleionis, 50 parts of cynanchum paniculatum and 140 parts of jujube peel.
The preparation method comprises the following steps:
step 1, weighing 50 parts of Chinese violet, 70 parts of fingered citron, 90 parts of holboellia latifolia, 70 parts of dandelion, 50 parts of poria cocos, 50 parts of green tangerine peel (fried), 20 parts of ligusticum wallichii, 70 parts of rhizoma corydalis, 40 parts of rhizoma pleionis, 50 parts of cynanchum paniculatum and 140 parts of jujube peel according to parts by weight;
Step 2, mixing the spina Gleditsiae, fructus Citri Sarcodactylis, fructus Akebiae, herba Taraxaci, Poria, and pericarpium Citri Reticulatae viride (parched), adding 5 times of water, decocting at 65 deg.C for 50min, filtering, and collecting filtrate to obtain mixture A;
Mixing the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel weighed in the step 1, adding water which is 5 times of the total weight of the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel, decocting for 50min at 85 ℃, filtering, and collecting filtrate to obtain a mixture B;
Uniformly mixing the mixture A and the mixture B, freeze-drying at-30 ℃ for 4h to obtain freeze-dried powder, adding a proper amount of auxiliary materials into the freeze-dried powder, uniformly mixing, granulating, sieving, drying, further tabletting the prepared granules, and drying to obtain the Chinese herbal medicine oral tablet for preventing and treating hyperplasia of mammary glands and lumps.
Example 3
a Chinese herbal medicine oral tablet capable of preventing and treating breast hyperplasia and lumps is prepared from the following raw materials in parts by weight: 70 parts of spina date seed, 90 parts of fingered citron, 110 parts of holboellia latifolia, 50 parts of dandelion, 70 parts of poria cocos, 70 parts of green tangerine peel (fried), 50 parts of ligusticum chuanxiong hort, 50 parts of rhizoma corydalis, 60 parts of rhizoma pleionis, 30 parts of cynanchum paniculatum and 160 parts of jujube peel.
The preparation method comprises the following steps:
Step 1, weighing 70 parts of spina date seed, 90 parts of fingered citron, 110 parts of holboellia latifolia, 50 parts of dandelion, 70 parts of poria cocos, 70 parts of green tangerine peel (fried), 50 parts of ligusticum wallichii, 50 parts of rhizoma corydalis, 60 parts of rhizoma pleionis, 30 parts of cynanchum paniculatum and 160 parts of jujube peel according to parts by weight;
Step 2, mixing the spina Gleditsiae, fructus Citri Sarcodactylis, fructus Akebiae, herba Taraxaci, Poria, and pericarpium Citri Reticulatae viride (parched), adding 5 times of water, decocting at 65 deg.C for 60min, filtering, and collecting filtrate to obtain mixture A;
Mixing the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel weighed in the step 1, adding water which is 5 times of the total weight of the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel, decocting at 85 ℃ for 60min, filtering, and collecting filtrate to obtain a mixture B;
uniformly mixing the mixture A and the mixture B, freeze-drying at-30 ℃ for 5h to obtain freeze-dried powder, adding a proper amount of auxiliary materials into the freeze-dried powder, uniformly mixing, granulating, sieving, drying, further tabletting the prepared granules, and drying to obtain the Chinese herbal medicine oral tablet for preventing and treating hyperplasia of mammary glands and lumps.
The Chinese herbal medicine oral tablets with good effects for preventing and treating hyperplasia and lumps of breasts are prepared in the examples 1 to 3, and the effects of the invention are explained only by adopting the Chinese herbal medicine oral tablets prepared in the example 1 because the effects of the Chinese herbal medicine oral tablets prepared in the examples 1 to 3 are basically parallel.
First, animal experiment
1. Test drugs
Runing, guangdong san shun pharmaceutical ltd;
Estradiol benzoate injection, tianjin jin Yao pharmaceutical Co., Ltd.
2. test animal
Healthy SD rats were not pregnant and weighed 180. + -.10 g.
3. test method
140 female non-pregnant rats are taken and randomly divided into 7 groups, wherein each group comprises 20, and the 7 groups are respectively a blank control group, a model group, a hyperplasia of mammary glands group (1.7g/kg), a Chinese herbal medicine oral tablet high dose group (5g crude drug/kg) in example 1, a Chinese herbal medicine oral tablet medium dose group (1.7g crude drug/kg) in example 1 and a Chinese herbal medicine oral tablet low dose group (0.5g crude drug/kg) in example 1. Except for a blank control group, each group of rats is injected with 0.6mg/kg of estradiol benzoate injection solution at the armpit every 1 day for 10 times, the blank control group is injected with sterile normal saline with the same volume as the estradiol benzoate injected by other groups of rats every 1 day, and each group of rats is respectively infused with corresponding medicaments or tap water with the same volume during each injection.
the third mammary gland is taken 24 hours after the last administration for embedding, slicing and HE staining, the pathological morphological change of the mammary glands is observed under a mirror, and grading comparison is carried out, which is shown in table 1.
Wherein, the pathological and histological grading standards of the mammary tissue are as follows:
stage I: the mammary gland has obvious lobules, the volume is increased, the number of acinus in the lobules is increased, the catheter is extremely expanded, and a large amount of secretion exists in the glandular cavity or the catheter;
II stage: mammary lobules are obvious, the volume is increased, but no I grade is obvious, a lumen or a duct is expanded, and secretion exists in the glandular cavity or the duct;
Grade III: the volume of the lobular hyperplasia of partial mammary glands is increased, the cavity of the gland or a duct is slightly dilated, and a small amount of secretion exists in the cavity of the gland or the duct;
grade IV (normal breast tissue): the lobules of the mammary gland are not hyperplastic, the acinus volume is normal, the cavity of the gland and the duct are not expanded, and no obvious secretion is seen in the cavity of the gland and the duct.
4. Test results
The results of the effect on mammary gland hyperplasia in mammary gland hyperplasia rats are shown in Table 1.
TABLE 1 Effect on mammary hyperplasia in mammary glands proliferating rats
| Group of | Class I | class II | Class III | Grade IV |
| Blank control group | 0 | 0 | 0 | 20 |
| Model set | 18 | 2 | 0 | 0 |
| Breast hyperplasia treating group | 15 | 5 | 0 | 0 |
| High dose group | 13 | 4 | 3 | 0 |
| Middle dose group | 15 | 3 | 2 | 0 |
| Low dose group | 16 | 2 | 2 | 0 |
As can be seen from Table 1, the mammary gland hyperplasia degree of the rats in the high-dose group is lighter than that of the rats in the model group, and the effect of the rats in the medium-dose group is equivalent to that of the rats in the model group, which shows that the Chinese herbal medicine oral tablet has a good inhibition effect on the mammary gland hyperplasia.
Second, clinical trial
1. hyperplasia of mammary glands
30 volunteers aged 35-45 years and having normal weight, all born one, were breastfed for 6-18 months, and had hyperplasia of breast after weaning. Breast examination: the breast is distended and sagged, and a small amount of hyperplasia of mammary glands can be touched, which belongs to mild or moderate hyperplasia.
after the Chinese herbal medicine oral tablet prepared in the embodiment 1 of the invention is taken, the effective component of the oral tablet is 75 mg/tablet, 3 times a day, 3-4 granules each time, the oral tablet is taken half an hour after meals, 30 days are taken continuously as a treatment course, then the examination is carried out respectively for 30 days, 60 days and 90 days, 90% of volunteers have soft breast nuclei and obviously improved mastoptosis, and through measurement, the breasts of all the volunteers are lifted by 0.4-0.8cm compared with the breasts before use, and the appearance is strong and stiff. All volunteers had no allergic reaction and no other allergic symptoms.
2. lump in breast
45 volunteers aged 22-45 years had a shortest disease course of 30 days and a longest disease course of 3 years. The main symptoms of the patients in this group are local lumps and distending pain, and the molybdenum target photography and diagnosis are the basis.
The patients are randomly divided into 3 groups, the Chinese herbal medicine oral tablets of the embodiments 1-3 are respectively taken, the effective component of the oral tablets is 0.75 mg/tablet, 3 times a day, 3-4 tablets each time, the oral tablets are taken half an hour after meals, 30 days are taken continuously as a treatment course, then the examination is carried out for 15 days, 30 days, 60 days and 90 days, 15 patients of the embodiment 1 group feel that the breast distending pain disappears, and the examination shows that the breast core becomes soft and the breast penetration examination is normal; 8 patients in the group of example 2 felt that the breast distending pain disappeared and the breast core became soft; the 11 patients of example 3 felt the breast distending pain disappeared, and the nucleus became soft as examined.
the effective patients continue to take the Chinese herbal medicine oral tablet in the trial, and no relapse occurs in one year of follow-up visit.
it should be noted that when the following claims refer to numerical ranges, it should be understood that both ends of each numerical range and any value between the two ends can be selected, and since the steps and methods used are the same as those in embodiments 1-3, the present invention describes preferred embodiments in order to prevent redundancy, but once the basic inventive concept is known, those skilled in the art can make other changes and modifications to these embodiments. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (5)
1. a Chinese herbal medicine composition for preventing and treating hyperplasia and lumps of breasts is characterized by being prepared from the following components in parts by weight:
50-70 parts of spina date seed, 70-90 parts of fingered citron, 90-110 parts of holboellia latifolia, 50-70 parts of dandelion, 50-70 parts of poria cocos, 50-70 parts of green tangerine peel (fried), 20-50 parts of ligusticum wallichii, 50-70 parts of rhizoma corydalis, 40-60 parts of rhizoma pleionis, 30-50 parts of cynanchum paniculatum and 160 parts of jujube peel 140-.
2. The Chinese herbal medicine composition for preventing and treating breast hyperplasia and lumps as claimed in claim 1, which is prepared from the following components in parts by weight:
60 parts of spina date seed, 80 parts of fingered citron, 100 parts of holboellia latifolia, 60 parts of dandelion, 60 parts of poria cocos, 60 parts of green tangerine peel (fried), 30 parts of ligusticum wallichii, 60 parts of rhizoma corydalis, 50 parts of rhizoma pleionis, 40 parts of cynanchum paniculatum and 150 parts of jujube peel.
3. the method for preparing a herbal composition for preventing and treating breast hyperplasia and lump as claimed in claim 1 or 2, comprising the steps of:
step 1, weighing 50-70 parts of spina date seed, 70-90 parts of fingered citron, 90-110 parts of holboellia latifolia, 50-70 parts of dandelion, 50-70 parts of poria cocos, 50-70 parts of green tangerine peel (fried), 20-50 parts of ligusticum wallichii, 50-70 parts of rhizoma corydalis, 40-60 parts of bulb of pleione, 30-50 parts of cynanchum paniculatum and 160 parts of jujube peel 140 and other materials in parts by weight;
Step 2, mixing the spina Gleditsiae, fructus Citri Sarcodactylis, fructus Akebiae, herba Taraxaci, Poria, and pericarpium Citri Reticulatae viride (parched), adding 5 times of water, decocting at 65 deg.C for 30-60min, filtering, and collecting filtrate to obtain mixture A;
mixing the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel weighed in the step 1, adding water which is 5 times of the total weight of the ligusticum wallichii, the rhizoma corydalis, the rhizoma pleionis, the paniculate swallowwort root and the jujube peel, decocting the mixture at 85 ℃ for 30-60min, filtering the decoction, and collecting filtrate to obtain a mixture B;
and uniformly mixing the mixture A and the mixture B, and then freeze-drying to obtain freeze-dried powder, namely the Chinese herbal medicine composition.
4. The method for preparing a herbal composition for the prevention and treatment of mammary gland hyperplasia and lump as claimed in claim 3, wherein the herbal composition is in the form of oral tablet.
5. The method for preparing a herbal composition for the prevention and treatment of breast hyperplasia and lump as claimed in claim 3, wherein the freeze-drying process conditions are as follows: freeze drying at-30 deg.C for 3-5 hr to obtain the lyophilized powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910925572.3A CN110575499A (en) | 2019-09-27 | 2019-09-27 | A Chinese medicinal composition for preventing and treating mammary gland hyperplasia and lump, and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910925572.3A CN110575499A (en) | 2019-09-27 | 2019-09-27 | A Chinese medicinal composition for preventing and treating mammary gland hyperplasia and lump, and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110575499A true CN110575499A (en) | 2019-12-17 |
Family
ID=68814006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910925572.3A Pending CN110575499A (en) | 2019-09-27 | 2019-09-27 | A Chinese medicinal composition for preventing and treating mammary gland hyperplasia and lump, and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110575499A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927288A (en) * | 2003-11-28 | 2007-03-14 | 江苏康缘药业股份有限公司 | Preparing art of cassia twig and Tuckahoe composition and use thereof |
| CN101259214A (en) * | 2008-04-29 | 2008-09-10 | 王爱玲 | Medicine for treating hyperplasia of mammary glands |
| CN103157012A (en) * | 2013-04-07 | 2013-06-19 | 贵州鸿德中药开发有限公司 | Hmong drug for treating cyclomastopathy |
| CN105411891A (en) * | 2015-08-20 | 2016-03-23 | 秦毅 | Breast nursing composition and preparation method thereof |
-
2019
- 2019-09-27 CN CN201910925572.3A patent/CN110575499A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927288A (en) * | 2003-11-28 | 2007-03-14 | 江苏康缘药业股份有限公司 | Preparing art of cassia twig and Tuckahoe composition and use thereof |
| CN101259214A (en) * | 2008-04-29 | 2008-09-10 | 王爱玲 | Medicine for treating hyperplasia of mammary glands |
| CN103157012A (en) * | 2013-04-07 | 2013-06-19 | 贵州鸿德中药开发有限公司 | Hmong drug for treating cyclomastopathy |
| CN105411891A (en) * | 2015-08-20 | 2016-03-23 | 秦毅 | Breast nursing composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王正林: "从肝郁论治乳腺增生病", 《山东中医杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103721131B (en) | A kind of Chinese medicine suppository and its preparation method treating women's chronic pelvic inflammatory disease | |
| CN105343625A (en) | Taraxacum oral liquid for expelling toxin, dehumidifying and benefiting gallbladder and preparation method thereof | |
| CN102178804B (en) | Chinese medicinal composition for treating perianal eczema and preparation method thereof | |
| CN103751310A (en) | External traditional Chinese medicinal preparation for treating fasciitis and preparation method thereof | |
| CN104274788A (en) | Traditional Chinese medicine composition for treating morbid leucorrhea due to liver-fire and damp-heat in women and preparation method of traditional Chinese medicine composition | |
| CN102078569B (en) | Traditional Chinese medicine preparation for treating liver cancer and preparation method thereof | |
| CN101711848B (en) | Chinese medicinal composition capable of adjunctively treating tumour | |
| CN101095923B (en) | Chinese traditional medicine for treating ectopic pregnancy | |
| CN104906465A (en) | Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof | |
| CN103520552B (en) | Traditional Chinese medicine composition for treating acute conjunctivitis and preparation method thereof | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN103977362A (en) | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and early-stage breast cancer | |
| CN101607067B (en) | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof | |
| CN103736017A (en) | Traditional Chinese medicine composition for treating intercostal neuralgia and preparation method of traditional Chinese medicine composition | |
| CN105125792A (en) | Traditional Chinese medicinal decoction for treating female mastitis and preparation method of decoction | |
| CN101524473B (en) | Worm grass anticancer longevity pellet and preparation method thereof | |
| CN110575499A (en) | A Chinese medicinal composition for preventing and treating mammary gland hyperplasia and lump, and its preparation method | |
| CN102526620A (en) | Traditional Chinese medicinal composition for treating gynecological inflammation and application of same | |
| CN103169838B (en) | Medicine for treating hepatitis B | |
| CN103405589B (en) | Traditional Chinese medicine composition for treating cow mastitis and preparation method thereof | |
| CN109771567A (en) | A kind of formula of Chinese herbal medicine supporting vital QI and dispersing blood stasis toxin expelling tumour | |
| CN111298061B (en) | Traditional Chinese medicine composition for clearing heat and detoxicating, removing stasis and resolving masses and preparation method thereof | |
| CN114533831B (en) | Traditional Chinese medicine composition with effects of warming middle-jiao, dispelling cold, eliminating dampness, promoting blood circulation, removing obstruction in channels and relieving pain and heat-covered bag thereof | |
| CN116115687B (en) | Traditional Chinese medicine composition for gout and preparation method and application thereof | |
| CN105031135A (en) | Traditional Chinese medicine composition for treating dysmenorrhea with liver and kidney deficiency syndrome and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191217 |
|
| RJ01 | Rejection of invention patent application after publication |