CN110575496A

CN110575496A - Medicine for treating deficiency of qi and blood and preparation method thereof

Info

Publication number: CN110575496A
Application number: CN201910969502.8A
Authority: CN
Inventors: 黄海平; 邬政付; 李颖; 王玉林; 李正胜; 王叶; 谢娟
Original assignee: Second Affiliated Hospital Of Guizhou University Of Traditional Chinese Medicine
Current assignee: Second Affiliated Hospital Of Guizhou University Of Traditional Chinese Medicine
Priority date: 2019-10-12
Filing date: 2019-10-12
Publication date: 2019-12-17

Abstract

The invention discloses a medicament for treating deficiency of qi and blood and a preparation method thereof, the medicament is prepared from astragalus root, pilose asiabell root, American ginseng, pseudostellaria root, ginseng, glossy privet fruit, eclipta alba, dodder, schisandra fruit, dwarf lilyturf tuber, Chinese angelica, prepared rhizome of rehmannia, donkey-hide gelatin, suberect spatholobus stem, fevervine herb, garden burnet root, rhubarb, serissa serissoide, raw iron filings, pseudo-ginseng, liquorice and Chinese date; the medicine provided by the invention has the effects of tonifying qi and blood and regulating viscera, can effectively treat deficiency of qi and blood, improve sub-health and improve the life quality of patients, and has the advantages of obvious curative effect, high safety, economy and practicability, and convenience in taking.

Description

Medicine for treating deficiency of qi and blood and preparation method thereof

Technical Field

The invention relates to a medicine for treating deficiency of qi and blood and a preparation method thereof, belonging to the technical field of medicines.

Background

Deficiency of qi and blood, i.e., deficiency of both qi and blood in traditional Chinese medicine, is a common syndrome of traditional Chinese medicine in the elderly, physically weak, and sub-healthy. Traditional Chinese medicine considers that qi and blood are basic substances which form a human body and are used for nourishing viscera and communicating viscera, so that hypofunction of viscera can be caused by deficiency of qi and blood. The records of Su Wen & Ting tiao Lun: "blood and qi disharmony, all diseases are caused by changes". Qi deficiency means poor mental status and poor resistance, manifested as aversion to cold, cold limbs, spontaneous perspiration, dizziness, tinnitus, listlessness, lassitude, palpitation, shortness of breath, etc. Blood deficiency can lead to lusterless sallow complexion, dry skin, withered hair, dry nails, dim eyesight, numb hands and feet, insomnia, dreaminess, amnesia, palpitation and absentmindedness.

Therefore, the invention discloses a medicine with obvious curative effect, the effects of tonifying qi and blood, adjusting internal organs and improving sub-health, and has important significance for treating deficiency of qi and blood.

Disclosure of Invention

The invention aims to provide a medicament for treating deficiency of qi and blood. The medicine provided by the invention has the effects of tonifying qi and blood and regulating viscera, can effectively treat deficiency of qi and blood, improve sub-health and improve the life quality of patients, and has the advantages of obvious curative effect, high safety, economy and practicability, and convenience in taking.

The technical scheme of the invention is as follows: a medicine for treating deficiency of qi and blood is prepared from 50-70 parts of astragalus root, 10-20 parts of codonopsis pilosula, 10-20 parts of American ginseng, 10-20 parts of radix pseudostellariae, 10-20 parts of ginseng, 10-20 parts of glossy privet fruit, 10-20 parts of eclipta alba, 10-20 parts of semen cuscutae, 10-20 parts of schisandra chinensis, 10-20 parts of radix ophiopogonis, 10-20 parts of angelica sinensis, 10-20 parts of prepared rehmannia root, 10-20 parts of donkey-hide gelatin, 20-40 parts of caulis spatholobi, 20-40 parts of paederia scandens, 10-20 parts of garden burnet root, 10-20 parts of rheum officinale, 50-70 parts of serissa serissoides, 5-15 parts of ferrite beads, 5-15 parts of pseudo-ginseng, 5-15 parts of liquorice and 5-15 parts of Chinese date according to.

In the medicine for treating deficiency of qi and blood, the medicinal effective components of the medicine are calculated according to the weight parts, and are prepared from 55-65 parts of astragalus membranaceus, 12-18 parts of codonopsis pilosula, 12-18 parts of American ginseng, 12-18 parts of radix pseudostellariae, 12-18 parts of ginseng, 12-18 parts of glossy privet fruit, 12-18 parts of eclipta alba, 12-18 parts of semen cuscutae, 12-18 parts of schisandra chinensis, 12-18 parts of radix ophiopogonis, 12-18 parts of angelica sinensis, 12-18 parts of prepared rhizome of rehmannia, 12-18 parts of donkey-hide gelatin, 25-35 parts of caulis spatholobi, 25-35 parts of paederia scandens, 12-18 parts of garden burnet root, 12-18 parts of rheum officinale, 55-65 parts of serissa serissoides, 7-13 parts of raw iron oxide, 7-13 parts of.

In the medicine for treating deficiency of qi and blood, the medicinal effective components of the medicine are calculated according to the weight parts, and are prepared from 60 parts of astragalus mongholicus, 15 parts of codonopsis pilosula, 15 parts of American ginseng, 15 parts of radix pseudostellariae, 15 parts of ginseng, 15 parts of glossy privet fruit, 15 parts of eclipta alba, 15 parts of semen cuscutae, 15 parts of schisandra chinensis, 15 parts of radix ophiopogonis, 15 parts of angelica sinensis, 15 parts of prepared rehmannia root, 15 parts of donkey-hide gelatin, 30 parts of caulis spatholobi, 30 parts of paederia scandens, 15 parts of sanguisorba officinalis, 15 parts of rheum officinale, 60 parts of serissa serissoides, 10 parts of raw iron.

The preparation method of the medicine for treating deficiency of qi and blood comprises the steps of taking astragalus, codonopsis pilosula, American ginseng, radix pseudostellariae, ginseng, glossy privet fruit, eclipta alba, semen cuscutae, schisandra chinensis, radix ophiopogonis, angelica sinensis, prepared rhizome of rehmannia, donkey-hide gelatin, caulis spatholobi, paederia scandens, garden burnet root, rheum officinale, serissa serissoides, pulvis ferri, pseudo-ginseng, liquorice and Chinese date, combining the astragalus, codonopsis pilosula, American ginseng, radix pseudostellariae, radix ophiopogonis, radix paeoniae alba, radix paeonia.

In the preparation method of the medicine for treating deficiency of qi and blood, the preparation is an oral preparation.

In the preparation method of the medicine for treating deficiency of qi and blood, the oral preparation is decoction, granules or soft extract.

In the preparation method of the medicine for treating deficiency of qi and blood, the decoction is prepared by the following steps: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 15-30 minutes, filtering, placing in a medicine decocting container, adding 3-6 times of clear water, boiling with strong fire, decocting for 15 minutes, decocting with slow fire for 15 minutes, filtering the decoction dregs while the decoction is hot, and retaining a decoction A; adding 2-4 times of clear water into the residue, boiling with strong fire, decocting for 10 min, decocting with slow fire for 10 min, filtering the residue while it is hot, and retaining decoction B; and placing the decoction A and the decoction B into a container, and refrigerating to obtain the decoction.

In the aforementioned method for preparing a medicament for treating insufficiency of qi and blood, the granules are prepared by: the granules are prepared by: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 15-30 minutes, filtering, placing in a medicine decocting container, adding 2-3 times of water, decocting for three times, each time for 30 minutes, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35 at 80 ℃, adding 33% of prepared dextrin and 48% of prepared sucrose, uniformly mixing, preparing into granules, and drying to obtain the granules.

In the above method for preparing a medicament for treating insufficiency of qi and blood, the soft extract is prepared by: weighing the above medicines according to a proportion, crushing into coarse powder, adding water, soaking for 20-30min, decocting for 3 times, decocting for 40min with 8 times of water for the first time, decocting for 30min with 6 times of water for the second time, decocting for 20min with 4 times of water for the third time, combining the three decoctions, filtering, concentrating into an extract with a relative density of 1.10-1.15 at 60-65 ℃, adding honey accounting for 50% of the extract into the extract, heating, mixing uniformly, concentrating into an extract with a relative density of 1.2-1.25 at 60-65 ℃, and obtaining the decocted extract.

The invention is prepared from Astragalus, codonopsis pilosula, American ginseng, radix pseudostellariae, ginseng, glossy privet fruit, eclipta alba, semen cuscutae, schisandra chinensis, radix ophiopogonis, angelica sinensis, prepared rhizome of rehmannia, donkey-hide gelatin, caulis spatholobi, paederia scandens, garden burnet root, rhubarb, serissa serissoides, pulvis ferri, pseudo-ginseng, liquorice and Chinese date, wherein the Astragalus, also named Astragalus membranaceus (scientific name: Astragalus propinquus Schischischkin) is a plant of Astragalus of leguminosae. Has effects of invigorating qi, consolidating superficial resistance, promoting urination, tonifying heart, lowering blood pressure, resisting bacteria, removing toxic substance, promoting pus discharge, promoting granulation, enhancing capillary resistance, arresting sweating, and treating exterior deficiency, spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency, diarrhea, edema, carbuncle, cellulitis, etc. Codonopsis pilosula, which is dried root of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (West Codonopsis pilosula) of Campanulaceae, Codonopsis pilosula Nannf, var. modesta (Nannf.) L.T. Shen or Codonopsis tangshen Oliv; the functional indications are as follows: tonify middle energizer, replenish qi, promote the production of body fluid. It is indicated for weakness of spleen and stomach, deficiency of both qi and blood, lassitude, weakness, poor appetite, thirst, chronic diarrhea, and rectocele. Radix Panacis Quinquefolii is dried root of Panax quinquefolium L. of Araliaceae; the functional indications are as follows: benefiting lung yin, clearing deficient fire, promoting fluid production to quench thirst; it is indicated for chronic cough due to lung deficiency, blood loss, dry throat, thirst, deficiency heat, restlessness and fatigue. Radix Pseudostellariae, which is dried root tuber of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm, belonging to family Caryophyllaceae; the functional indications are as follows: to replenish qi, invigorate the spleen, promote the production of body fluid and moisten the lung. Can be used for treating spleen deficiency, asthenia, deficiency of both qi and yin, spontaneous perspiration, thirst, and dry cough due to lung dryness. The original name of the ginseng is as follows: root of straight ladybell, another name: adenophora tetraphylla, adenophora stricta, adenophora vesiculosa, latin name: adenophora capillaris hemsl. of family Campanulaceae, genus Adenophora; has effects in clearing away heat, nourishing yin, moistening lung, and relieving cough; can be used for treating tracheitis, pertussis, cough due to lung heat, and yellow and thick expectoration. Fructus Ligustri Lucidi, which is dried mature fruit of Ligustrum lucidum air of Oleaceae; the functional indications are as follows: nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating vertigo, tinnitus, soreness of waist and knees, premature gray hair, and dim eyesight. Eclipta alba, which is a dry aerial part of Eclipta prostrata L. of Eclipta prostrata of Compositae; the functional indications are as follows: nourishing liver and kidney, cooling blood and stopping bleeding. Can be used for treating odontoseisis, premature gray hair, giddiness, tinnitus, soreness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, dysentery with bloody stool, metrorrhagia, metrostaxis, and traumatic hemorrhage. Semen Cuscutae, which is dried mature seed of Cuscuta chinensis Lam of Convolvulaceae; the functional indications are as follows: nourishing liver and kidney, arresting seminal emission, arresting polyuria, preventing miscarriage, improving eyesight, and relieving diarrhea; can be used for treating sexual impotence, spermatorrhea, enuresis, frequent micturition, soreness of waist and knees, blurred vision, tinnitus, fetal leakage due to kidney deficiency, threatened abortion, and spleen and kidney deficiency; externally treat vitiligo. Fructus Schisandrae, dry ripe fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra sphenanthera Rehd. et Wils. of Magnoliaceae; the functional indications are as follows: astringe, benefit qi, promote the production of body fluid, tonify kidney, calm heart; can be used for treating chronic cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, short breath, weak pulse, internal heat, diabetes, palpitation, and insomnia. Radix Ophiopogonis is dried root tuber of Ophiopogon japonica (Thunb.) Ker-Gawl. of Liliaceae; the functional indications are as follows: nourish yin, promote the production of body fluid, moisten lung and clear away heart-fire. Used for treating dry cough due to lung dryness; cough due to consumptive disease, thirst due to body fluid consumption, vexation, insomnia, internal heat, diabetes, constipation due to intestinal dryness; and (4) pharyngeal diphtheria. Angelica sinensis, a dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae; the functional indications are as follows: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury. Radix rehmanniae Preparata (root tuber of Rehmannia glutinosa Libosch of Scrophulariaceae), and processing; has effects of replenishing blood and nourishing yin, and can be used for treating blood deficiency and chlorosis, giddiness, cardiopalmus and insomnia, menoxenia, metrorrhagia, etc., and can also be used for treating hectic fever and bone steaming due to kidney yin deficiency, night sweat, spermatorrhea, diabetes, etc. Colla Corii Asini is solid glue prepared by decocting and concentrating skin of Equus Asinus L. of Equus equi of Equus; the functional indications are as follows: enriching blood, nourishing yin, moistening dryness and stopping bleeding; can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, muscle weakness, vexation, insomnia, deficient wind stirring, cough due to dryness of lung, overstrain cough, hemoptysis, hematemesis, hematuria, hematochezia, metrorrhagia, and gestational fetal leakage. Caulis Spatholobi, which is dried rattan of Spatholobus suberectus Dunn of Leguminosae (caulis Sargentodoxae, caulis Spatholobi Trifolium Pratentis, and caulis et folium Gaultheriae Yunnanensis); the functional indications are as follows: enriching blood, promoting blood circulation and dredging collaterals; can be used for treating menoxenia, blood deficiency, sallow complexion, numbness, paralysis, and rheumatalgia. Herba Paederiae, Paederia scandens (Lour.) Merr, belonging to Paederia genus of Rubiaceae family, and is prepared from root or whole herb; the functional indications are as follows: dispelling pathogenic wind, promoting diuresis, resolving food stagnation, relieving cough, and relieving pain; can be used for treating rheumatism osteodynia, traumatic injury, traumatic pain, liver and gallbladder and gastrointestinal colic, icteric hepatitis, enteritis, dysentery, dyspepsia, infantile malnutrition, pulmonary tuberculosis hemoptysis, bronchitis, leukopenia due to radiation reaction, and pesticide poisoning; it is used externally to treat dermatitis, eczema, sore, ulcer and pyogenic infections. Sanguisorba officinalis, which is dried root of Sanguisorba officinalis L. or Sanguisorba longata L. var. longifolia (Bert.) Yu et Li; the functional indications are as follows: cool blood to stop bleeding, remove toxicity and heal wound; can be used for treating hematochezia, hemorrhoidal bleeding, bloody dysentery, metrorrhagia, scald due to hot water and fire, carbuncle, swelling, and sore. Radix et rhizoma Rhei (Rheum palmatum L. of Polygonaceae) is provided. And Rheumatodegum Maxim Maxim. ex Balf. Or dried root and rhizome of Rheum officinale Baill. ex Palmati; the functional indications are as follows: purging heat, promoting intestinal function, cooling blood, removing toxic substances, removing blood stasis, and dredging channels; used for treating excessive heat constipation, abdominal pain due to stagnation, dysentery, damp-heat jaundice, blood heat hematemesis, conjunctival congestion, pharyngeal swelling, acute appendicitis, abdominal pain, carbuncle, furuncle, amenorrhea due to blood stasis, traumatic injury, and scald due to hot water and fire; upper gastrointestinal hemorrhage. Serissa serissoides (DC.) Druce of Serissoides of Serissoniaceae, which is used as whole plant; the functional indications are as follows: dispelling wind, relieving exterior syndrome, clearing heat, promoting diuresis, relaxing muscles and tendons, and activating collaterals; can be used for treating common cold, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute and chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension, headache, migraine, rheumatic arthralgia, and leucorrhea; the stem burns and ashes to spot on eyes to treat nebula. The pig iron scraps are scrap iron scraps which are knocked down due to the oxidation of the outer layer during iron knocking, or scrap iron which is a byproduct during iron forging in an iron factory; the functional indications are as follows: calming the liver and relieving convulsion; it is used for treating fright. Notoginseng radix, which is dried root of Panax notoginseng (Burk.) F.H. Chen of Araliaceae family; the functional indications are as follows: stasis dissipating, bleeding stopping, swelling subsiding and pain relieving; can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic swelling and pain. Licorice, which is the dried root of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of Leguminosae; the functional indications are as follows: invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the above medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature. Fructus Jujubae, dried mature fruit of Ziziphus jujuba Mill. var. inermis (Bunge) Rehd. belonging to Ziziphus of Rhamnaceae; the functional indications are as follows: invigorating spleen, replenishing qi, nourishing blood, and tranquilizing; can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.

square solution: in the formula, a large amount of astragalus is combined with four ginseng to tonify qi, wherein the codonopsis pilosula tonifies middle-jiao and qi, strengthens spleen and lung, the American ginseng and the radix pseudostellariae clear away heat and nourish yin, promotes fluid and quenches thirst, the ginseng is soaked to tonify lung and kidney, promotes fluid and lowers fire, and the five medicines are used together to tonify qi deficiency of viscera; the golden kui hou xuan, a reel, fire, said that "qi is surplus and then is fire", there is a statement of "strong fire and eating qi, lack fire and engendering qi" in Su Wen & Yin Yang correspondence theory, in order to avoid qi from being burnt and then consuming qi by consuming saliva, fructus ligustri lucidi, herba ecliptae, semen cuscutae are added in the prescription to nourish yin and reduce fire, and at the same time to tonify liver and kidney, strengthen tendons and bones, the Shen nong herbal Jing lists radix ophiopogonis the superior product for nourishing yin and moistening lung, said that it is "taking for a long time and light, not old but hungry", and radix ophiopogonis is added to nourish yin and clear away the lung-heat and stomach-; the formula contains pig iron, has the efficacy of calming the liver and depressing qi, and is used for avoiding adverse rise of qi caused by excessive qi tonifying; the angelica, the prepared rhizome of rehmannia, the donkey-hide gelatin, the suberect spatholobus stem, the Chinese fevervine and the Chinese date are used together to nourish blood and enrich blood, and also can activate blood and circulate blood; the garden burnet and the rhubarb cool blood to stop bleeding, clear heat and detoxify, avoid blood stasis and internal injury caused by excessive blood enrichment; the seedling drug of the genus Serratula is used for introducing drugs into kidney to fill the congenital origin; licorice root, radix Glycyrrhizae is sweet in nature and acts as a key to harmonize the effects of the other drugs in the recipe. The medicines are combined to play the characteristics of greatly invigorating qi and blood, tonifying qi without transforming fire and enriching blood without stasis.

The western medicine pharmacological research shows that: radix astragali, radix Codonopsis, radix Ginseng, radix Angelicae sinensis, radix rehmanniae Preparata, and colla Corii Asini all have effects of enhancing immunity; radix Pseudostellariae can be weakened after illness, and is listed as a traditional Chinese medicine material for health promotion by the Ministry of health; the saponin in the American ginseng can effectively strengthen the central nerve, and achieve the effects of calming the heart, concentrating the mind, eliminating fatigue, enhancing memory and the like; fructus Ligustri Lucidi, Ecliptae herba, and semen Cuscutae have effects of lowering blood sugar, reducing blood lipid, and regulating immunity; the radix ophiopogonis has the effects of resisting fatigue, eliminating free radicals, improving the cellular immune function and reducing blood sugar; caulis Spatholobi and herba Paederiae can increase hemopoiesis function; radix Sangusorbae and radix et rhizoma Rhei have effects of stopping bleeding, cooling blood, clearing away heat and toxic materials. In summary, the above herbs can be summarized according to modern medical research: resistance is increased; increasing hematopoietic function; improving blood coagulation function, and preventing thrombosis.

Compared with the prior art, the medicine has the effects of tonifying qi and blood and regulating internal organs, can effectively treat deficiency of qi and blood, improves sub-health, improves the life quality of patients, and has the advantages of obvious curative effect, high safety, economy and practicability, and convenient administration.

The applicant carried out a large number of experimental studies to verify the effects of the present invention, and the following are the results of the experimental studies of the present invention:

Experimental example, clinical study:

The patient was initially diagnosed in Sunzhi, male, age 81, 11 months and 5 days in 2018. Before 1 week, patients suffered from cold and suffered from symptoms of weakness of limbs, chest distress, asthma, anorexia, fever, aversion to cold, headache, neck and back pain, no abdominal pain, morning diarrhea and the like, and input antibiotics (not detailed) in clinics has poor treatment effect, urinary incontinence and loose stool. Body examination: pale and white tongue with thin coating and deep and thready pulse. When the wheelchair is pushed into a diagnosis room, the chronic disease is manifested as anemia, shortness of breath, low respiratory sound of auscultation of both lungs, and no dry or wet rale. Auxiliary checking: blood routine: 8.24x10^9/L white blood cells, 2.51x10^12/L red blood cells and 102g/L hemoglobin. Traditional Chinese medicine diagnosis: consumptive disease, syndrome differentiation of deficiency of both qi and blood. The treatment mainly aims at invigorating qi and blood and regulating qi, and the medicament prepared in the embodiment 1 is taken. The patient is retested for 11 months and 16 days in 2018, the symptoms of asthma and short breath are improved, the quality of the patient is soft, the hypodynamia is relieved, the complexion is obviously improved compared with the initial diagnosis, and the patient continues to take the medicine. Three diagnoses in 12 months and 26 days in 2018, the patient walks into the office with a cane and the sound is loud. And (4) rechecking: blood routine: 6.54x10^9/L white blood cells, 3.42x10^12/L red blood cells and 120g/L hemoglobin.

The patient was initially diagnosed in 21 months in 2019 with Wangzhi and Nu in 37 years old. The patient is diagnosed for the treatment of 'repeated sleep disorder for 1 month', and the patient begins to have sleep disorder before complaint for 1 month because of working fatigue, and has difficulty in falling asleep, difficult sleep to roll, easy awakening and nightmare after falling asleep, accompanied by listlessness, lassitude, hypodynamia, anorexia, dizziness, hypomnesis, no fever, chilly sensation, no nausea, vomiting, no symptoms such as headache, palpitation and the like, frequent urination at night for 2 times/night, and mushy excrement is formed every morning. Body examination: the tongue is pale red with teeth marks, thin coating, deep, thready and weak pulse, and no special condition exists. Traditional Chinese medicine diagnosis: insomnia is marked by syndrome differentiation due to deficiency of qi and blood and malnutrition due to purgation. The treatment aims at tonifying qi and blood, and clearing orifices, the formula is modified by Fuzheng Guyuan powder, 60g of astragalus membranaceus, 15g of codonopsis pilosula, 15g of American ginseng, 15g of radix pseudostellariae, 15g of ginseng, 15g of glossy privet fruit, 15g of eclipta alba, 15g of semen cuscutae, 15g of schisandra chinensis, 15g of radix ophiopogonis, 15g of angelica sinensis, 15g of prepared rehmannia root, 15g of donkey-hide gelatin, 30g of caulis spatholobi, 30g of paederia scandens, 15g of sanguisorba officinalis, 15g of rheum officinale, 60g of serissa serissoides, 10g of raw iron powder, 10g of pseudo. Order to take 14 doses. The patient is retested for 12 months and 15 days in 2018, complains of sleep and recovers to normal, and the attention is concentrated. Physical examination: a pale and white tongue with thin and white coating and a flat and forceful pulse.

In conclusion, the medicine provided by the invention has the effects of tonifying qi and blood and regulating viscera, can effectively treat deficiency of qi and blood, improve sub-health, and improve the life quality of patients, and has the advantages of obvious curative effect, high safety, economy and convenience in taking.

Detailed Description

The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.

example 1 decoction for treating deficiency of qi and blood and preparation method thereof

The formula is as follows: 60g of astragalus membranaceus, 15g of codonopsis pilosula, 15g of American ginseng, 15g of radix pseudostellariae, 15g of ginseng, 15g of glossy privet fruit, 15g of eclipta alba, 15g of semen cuscutae, 15g of schisandra chinensis, 15g of radix ophiopogonis, 15g of angelica sinensis, 15g of radix rehmanniae preparata, 15g of donkey-hide gelatin, 30g of caulis spatholobi, 30g of paederia scandens, 15g of sanguisorba officinalis, 15g of rheum officinale, 60g of serissa serissoides, 10g of raw ferrite, 10g of pseudo-ginseng, 10 g.

The preparation method comprises the following steps: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 20 minutes, filtering, placing in a decocting container, adding 4 times of clear water, boiling with strong fire, decocting for 15 minutes, decocting with slow fire for 15 minutes, filtering the decoction dregs while the decoction is hot, and keeping a decoction A; adding 3 times of clear water into the residue, boiling with strong fire, decocting for 10 min, decocting with slow fire for 10 min, filtering the residue while it is hot, and retaining decoction B; and placing the decoction A and the decoction B into a container, and refrigerating to obtain the decoction.

The usage and dosage are as follows: the medicine liquid is taken orally, 50-100 ml of the medicine liquid is taken every time, and the medicine liquid is taken three times a day.

Example 2 granules for treating deficiency of qi and blood and preparation method thereof

The formula is as follows: 55g of astragalus membranaceus, 12g of codonopsis pilosula, 12g of American ginseng, 12g of radix pseudostellariae, 12g of ginseng, 12g of glossy privet fruit, 12g of eclipta alba, 12g of semen cuscutae, 12g of schisandra chinensis, 12g of radix ophiopogonis, 12g of angelica sinensis, 12g of radix rehmanniae preparata, 12g of donkey-hide gelatin, 25g of caulis spatholobi, 25g of paederia scandens, 12g of sanguisorba officinalis, 12g of rheum officinale, 55g of serissa serissoides, 7g of raw ferrite, 7g of pseudo-ginseng, 7 g.

The preparation method comprises the following steps: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 15-30 minutes, filtering, placing in a medicine decocting container, adding 2-3 times of water, decocting for three times, each time for 30 minutes, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35 at 80 ℃, adding 33% of prepared dextrin and 48% of prepared sucrose, uniformly mixing, preparing into granules, drying, and subpackaging into 15 g/bag to obtain the granules.

The usage and dosage are as follows: the medicine is taken with 50ml warm water 1 bag each time and three times a day.

Example 3 granule for treating deficiency of qi and blood and preparation method thereof

The formula is as follows: 65g of astragalus membranaceus, 18g of codonopsis pilosula, 18g of American ginseng, 18g of radix pseudostellariae, 18g of ginseng, 18g of glossy privet fruit, 18g of eclipta alba, 18g of semen cuscutae, 18g of schisandra chinensis, 18g of radix ophiopogonis, 18g of angelica sinensis, 18g of radix rehmanniae preparata, 18g of donkey-hide gelatin, 35g of caulis spatholobi, 35g of paederia scandens, 18g of sanguisorba officinalis, 18g of rheum officinale, 65g of serissa serissoides, 13g of raw iron filings, 13g of pseudo-ginseng.

The preparation method comprises the following steps: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 15-30 minutes, filtering, placing in a medicine decocting container, adding 2-3 times of water, decocting for three times, each time for 30 minutes, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35 at 80 ℃, adding 33% of prepared dextrin and 48% of prepared sucrose, uniformly mixing, preparing into granules, drying, and subpackaging into 20 g/bag to obtain the granules.

Example 4 Soft extract for treating deficiency of qi and blood and method for preparing the same

The formula is as follows: 50g of astragalus membranaceus, 10g of codonopsis pilosula, 10g of American ginseng, 10g of radix pseudostellariae, 10g of ginseng, 10g of glossy privet fruit, 10g of eclipta alba, 10g of semen cuscutae, 10g of schisandra chinensis, 10g of radix ophiopogonis, 10g of angelica sinensis, 10g of radix rehmanniae preparata, 10g of donkey-hide gelatin, 20g of caulis spatholobi, 20g of paederia scandens, 10g of sanguisorba officinalis, 10g of rheum officinale, 50g of serissa serissoides, 5g of raw ferrite, 5g of pseudo-ginseng, 5 g.

The preparation method comprises the following steps: weighing the above medicines according to a proportion, crushing into coarse powder, adding water, soaking for 25min, decocting for 3 times, decocting for 40min with 8 times of water for the first time, decocting for 30min with 6 times of water for the second time, decocting for 20min with 4 times of water for the third time, combining the three decoctions, filtering, concentrating into an extract with a relative density of 1.13 at 60 ℃, adding honey accounting for 50% of the extract into the extract, heating, mixing uniformly, concentrating into an extract with a relative density of 1.22 at 60 ℃, and obtaining the decocted extract.

The usage and dosage are as follows: it is taken with warm water 10-15g each time three times a day.

Claims

1. A medicament for treating deficiency of qi and blood, which is characterized in that: the medicinal effective components are calculated according to the weight parts, and are prepared from 50-70 parts of astragalus root, 10-20 parts of codonopsis pilosula, 10-20 parts of American ginseng, 10-20 parts of radix pseudostellariae, 10-20 parts of ginseng, 10-20 parts of glossy privet fruit, 10-20 parts of eclipta alba, 10-20 parts of semen cuscutae, 10-20 parts of schisandra chinensis, 10-20 parts of radix ophiopogonis, 10-20 parts of angelica sinensis, 10-20 parts of prepared rhizome of rehmannia, 10-20 parts of donkey-hide gelatin, 20-40 parts of caulis spatholobi, 20-40 parts of paederia scandens, 10-20 parts of garden burnet root, 10-20 parts of rheum officinale, 50-70 parts of serissa serissoides, 5-15 parts of ferrite bead, 5-15 parts of pseudo-ginseng, 5-15.

2. The drug for treating deficiency of both qi and blood according to claim 1, characterized in that: the medicinal active ingredients of the medicine are calculated according to the weight parts, and are prepared from 55-65 parts of astragalus root, 12-18 parts of codonopsis pilosula, 12-18 parts of American ginseng, 12-18 parts of radix pseudostellariae, 12-18 parts of ginseng, 12-18 parts of glossy privet fruit, 12-18 parts of eclipta alba, 12-18 parts of semen cuscutae, 12-18 parts of schisandra chinensis, 12-18 parts of radix ophiopogonis, 12-18 parts of angelica sinensis, 12-18 parts of prepared rhizome of rehmannia, 12-18 parts of donkey-hide gelatin, 25-35 parts of caulis spatholobi, 25-35 parts of fevervine, 12-18 parts of garden burnet root, 12-18 parts of rheum officinale, 55-65 parts of serissa serissoides, 7-13 parts of raw iron filings, 7-13 parts of pseudo-ginseng, 7-13.

3. The drug for treating deficiency of both qi and blood according to claim 2, characterized in that: the medicinal active ingredients of the medicine are calculated according to the weight parts, and are prepared from 60 parts of astragalus root, 15 parts of codonopsis pilosula, 15 parts of American ginseng, 15 parts of radix pseudostellariae, 15 parts of ginseng, 15 parts of glossy privet fruit, 15 parts of eclipta alba, 15 parts of semen cuscutae, 15 parts of schisandra chinensis, 15 parts of radix ophiopogonis, 15 parts of angelica, 15 parts of prepared rhizome of rehmannia, 15 parts of donkey-hide gelatin, 30 parts of caulis spatholobi, 30 parts of paederia scandens, 15 parts of garden burnet root, 15 parts of rhubarb, 60 parts of serissa serissoides, 10 parts of raw iron, 10 parts of pseudo-ginseng.

4. A method for the preparation of a medicament according to any one of claims 1 to 3 for the treatment of deficiency of both qi and blood, wherein: combining radix astragali, radix Codonopsis, radix Panacis Quinquefolii, radix Pseudostellariae, radix Codonopsis, fructus Ligustri Lucidi, Ecliptae herba, semen Cuscutae, fructus Schisandrae, radix Ophiopogonis, radix Angelicae sinensis, radix rehmanniae Preparata, colla Corii Asini, caulis Spatholobi, herba Paederiae, radix Sangusorbae, radix et rhizoma Rhei, herba Artemisiae Anomalae, pulvis Ferri, Notoginseng radix, Glycyrrhrizae radix and fructus Jujubae with pharmaceutically acceptable adjuvants or without adjuvants, processing by conventional method, and making into corresponding preparation.

5. The method for preparing a medicament for treating deficiency of both qi and blood according to claim 4, wherein: the preparation is an oral preparation.

6. The method for preparing a medicament for treating deficiency of both qi and blood according to claim 5, wherein: the oral preparation is decoction, granule or soft extract.

7. The method for preparing a medicament for treating deficiency of both qi and blood according to claim 6, wherein: the decoction is prepared by the following steps: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 15-30 minutes, filtering, placing in a medicine decocting container, adding 3-6 times of clear water, boiling with strong fire, decocting for 15 minutes, decocting with slow fire for 15 minutes, filtering the decoction dregs while the decoction is hot, and retaining a decoction A; adding 2-4 times of clear water into the residue, boiling with strong fire, decocting for 10 min, decocting with slow fire for 10 min, filtering the residue while it is hot, and retaining decoction B; and placing the decoction A and the decoction B into a container, and refrigerating to obtain the decoction.

8. The method for preparing a medicament for treating deficiency of both qi and blood according to claim 6, wherein: the granules are prepared by: weighing the medicines according to a proportion, cleaning, soaking the cleaned medicines in clear water for 15-30 minutes, filtering, placing in a medicine decocting container, adding 2-3 times of water, decocting for three times, each time for 30 minutes, combining the decoctions, filtering, concentrating the filtrate to a thick paste with a relative density of 1.30-1.35 at 80 ℃, adding 33% of prepared dextrin and 48% of prepared sucrose, uniformly mixing, preparing into granules, and drying to obtain the granules.

9. The method for preparing a medicament for treating deficiency of both qi and blood according to claim 6, wherein: the soft extract is prepared by: weighing the above medicines according to a proportion, crushing into coarse powder, adding water, soaking for 20-30min, decocting for 3 times, decocting for 40min with 8 times of water for the first time, decocting for 30min with 6 times of water for the second time, decocting for 20min with 4 times of water for the third time, combining the three decoctions, filtering, concentrating into an extract with a relative density of 1.10-1.15 at 60-65 ℃, adding honey accounting for 50% of the extract into the extract, heating, mixing uniformly, concentrating into an extract with a relative density of 1.2-1.25 at 60-65 ℃, and obtaining the decocted extract.