CN110551368A

CN110551368A - Medical polymer composition easy to weld and preparation method thereof

Info

Publication number: CN110551368A
Application number: CN201810534640.9A
Authority: CN
Inventors: 颜勇
Original assignee: Foshan Jiayi Agricultural Science And Technology Co Ltd
Current assignee: Foshan Jiayi Agricultural Science And Technology Co Ltd
Priority date: 2018-05-30
Filing date: 2018-05-30
Publication date: 2019-12-10

Abstract

The invention discloses a medical polymer composition easy to weld and a preparation method thereof, wherein the composition comprises, by weight, 20-80% of polylactic acid, 1.9-10% of styrene-maleic anhydride-cycloolefin copolymer, 10-70% of propylene-ethylene block copolymer and 8.1 ~ 20% of polyhedral organic silsesquioxane, and the gas is prepared by mixing the weighed polylactic acid, styrene-maleic anhydride-cycloolefin copolymer, propylene-ethylene block copolymer and polyhedral organic silsesquioxane, and extruding and granulating the mixture by a double-screw extruder.

Description

Medical polymer composition easy to weld and preparation method thereof

Technical Field

The invention relates to the technical field of medical polymer compositions, in particular to a medical polymer composition easy to weld and a preparation method thereof.

Background

A polymer material is a material based on a polymer compound. The polymer material is a material composed of compounds with relatively high molecular mass, and comprises rubber, plastics, fibers, paint, an adhesive and a polymer-based composite material, and the polymer is a life existing form. All living organisms can be regarded as a collection of macromolecules.

The polymer materials are classified into natural, semisynthetic (modified natural polymer materials) and synthetic polymer materials according to their sources. Natural macromolecules are the basis of life origin and evolution. The human society has utilized natural polymer materials as living materials and production materials from the beginning, and has mastered its processing technology. Such as weaving fabric with silk, cotton and wool, and making paper with wood, cotton and hemp. At the end of the 30 s in the 19 th century, a semi-synthetic polymer material appeared in the modification stage of natural polymer chemistry. In 1907, synthetic high molecular phenol formaldehyde resin appeared, which marks the beginning of the application of synthetic high molecular materials by human beings. In modern times, high molecular materials are the same as metal materials and inorganic non-metal materials, and become important materials in scientific, technical and economic construction.

The structure of the high polymer material determines the performance of the high polymer material, and the high polymer material with different characteristics can be obtained by controlling and modifying the structure. The polymer material has unique structure, easy modification and easy processing, so that the polymer material has excellent performance incomparable and irreplaceable with other materials, is widely applied to the fields of science and technology, national defense construction and national economy, and becomes an indispensable material for various aspects of clothes, food and housing in modern social life. Many natural materials are generally composed of high molecular materials, such as natural rubber, cotton, human organs, etc. As are synthetic chemical fibers, plastics, rubbers, and the like. Generally, a polymer which is widely used in life and has already been industrially produced is a general-purpose polymer material, and a functional polymer having a special purpose and function is referred to.

The medical polymer material is used for manufacturing human internal organs, external organs, drug dosage forms and medical appliances, and the source of the medical polymer material comprises natural biological polymer materials and synthetic biological polymer materials. The natural medical polymer material comes from nature and comprises cellulose, chitin, hyaluronic acid, collagen, gelatin, sodium alginate and the like; the synthetic medical polymer material is a polymer material artificially synthesized by a chemical method and used for medical purposes, and currently, polyurethane, silicon rubber, polyester fiber, polyvinylpyrrolidone, polyether ether ketone, polymethyl methacrylate, polyvinyl alcohol, polylactic acid, polyethylene and the like are commonly used.

Medical polymer materials can be classified into two major categories, non-degradable and biodegradable, according to the properties of the materials. Wherein the non-biodegradable material comprises: polyethylene, polypropylene, polyacrylate, aromatic polyester, silicone rubber, polyurethane, polyether ether ketone and the like, which can be kept stable for a long time in a physiological environment, do not degrade, crosslink, physically wear and the like, and have good mechanical properties. The material is mainly used for repairing soft and hard tissues of a human body and manufacturing artificial organs, artificial blood vessels, contact lenses, adhesives and the like. The degradable biological material comprises: collagen, aliphatic polyester, chitin, cellulose, polyamino acid, polyvinyl alcohol, polylactic acid, polycaprolactone, polyphosphazene and the like, wherein the materials can generate structural damage in a physiological environment, and degradation products can be absorbed by an organism or discharged out of the body through normal metabolism, and the materials are mainly used for drug release carriers and non-permanent implantation instruments.

The medical high molecular material is used for manufacturing human internal organs, external organs, drug dosage forms and medical appliances. According to the specific application, the method can be divided into the following steps: (1) a material not in direct contact with a living tissue; such as medicament containers, plasma bags, transfusion sets, syringes, laboratory supplies, operating room supplies, etc.; (2) materials contacting skin and mucosa, such as surgical gloves, anesthesia articles (oxygen tubes, masks, trachea cannula, etc.), medical articles (eye washing tools, otoscopes, tongue depressors, enemas, intestines, stomach, esophageal speculum catheters and probes, portal scopes, catheters, etc.), bandages, plasters, etc., and human body cosmetic repair materials (artificial limbs, artificial ears, artificial eyes, artificial noses, etc.); (3) materials that come into short-term contact with human tissue, such as: artificial blood vessels, artificial hearts, artificial lungs, artificial kidneys, dialysis membrane artificial skins, and the like; (4) materials implanted into the body for a long time, such as hydrocephalus medullary fluid drainage tube, artificial blood vessel, artificial valve, artificial trachea, artificial urethra, artificial bone, artificial joint, operation suture and tissue adhesive; (5) medicinal polymers include macromolecular drugs and drug polymers. The macromolecular medicine refers to the traditional macromolecular medicine such as the poly penicillin; the medicinal polymer is a polymer having pharmacological functions, such as interferon inducer of anionic polymer type. Medical polymer materials with different purposes need to be selected according to the use environment and the requirements on physical, chemical and biological properties of the materials.

Compared with single polylactic acid, styrene-maleic anhydride-cycloolefin copolymer and propylene-ethylene block copolymer, the blend of polylactic acid, styrene-maleic anhydride-cycloolefin copolymer and propylene-ethylene block copolymer has obvious improvement on the performance, such as processability, extrusion, spinning and injection blow molding, and has greatly improved glossiness, transparency and handfeel, thereby having wide prospect in the medical field, but the fusion welding ratio of the traditional medical polymer material is poor, and the use requirement is difficult to meet.

Disclosure of Invention

The present invention is directed to a medical polymer composition that is easily weldable and a method for preparing the same, which solves the problems of the background art described above.

In order to achieve the purpose, the invention provides the following technical scheme:

The invention relates to a medical polymer composition easy to weld, which comprises the following components, by weight, 20-80% of polylactic acid, 1.9-10% of styrene-maleic anhydride-cycloolefin copolymer, 10-70% of propylene-ethylene block copolymer and 8.1 ~ 20% of polyhedral organic silsesquioxane.

The invention further comprises the following components, by weight, 30-60% of polylactic acid, 7.9-9% of styrene-maleic anhydride-cycloolefin copolymer, 20-50% of propylene-ethylene block copolymer and 12.1 ~ 20% of polyhedral organic silsesquioxane.

the invention is based on a blend of polylactic acid, styrene-maleic anhydride-cycloolefin copolymer and propylene-ethylene block copolymer, polyhedral organic silsesquioxane is added, on the premise of not changing the original properties of polylactic acid, styrene-maleic anhydride-cycloolefin copolymer and propylene-ethylene block copolymer, the solvent solubility, the ultrasonic vibration performance and the laser absorption performance of the composition are provided through the introduced organic groups and Si-O bonds, thereby enabling the composition of polylactic acid, styrene-maleic anhydride-cycloolefin copolymer and propylene-ethylene block copolymer to have solvent welding performance and improving the ultrasonic and laser welding performance of the composition of polylactic acid, styrene-maleic anhydride-cycloolefin copolymer and propylene-ethylene block copolymer.

Another object of the present invention is to provide a method for preparing the above easily weldable medical polymer composition:

Mixing weighed polylactic acid, styrene-maleic anhydride-cycloolefin copolymer, propylene-ethylene block copolymer and polyhedral organic silsesquioxane, and extruding and granulating by a double-screw extruder.

Compared with the prior art, the composition has good processability, and has the advantages of extrusion, spinning, injection blow molding, glossiness and transparency; and the combined processing technology is simple, convenient to produce and convenient for large-scale production.

Detailed Description

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

The invention relates to a medical polymer composition easy to weld and a preparation method thereof, wherein the medical polymer composition comprises, by weight, 20-80% of polylactic acid, 1.9-10% of styrene-maleic anhydride-cycloolefin copolymer, 10-70% of propylene-ethylene block copolymer and 8.1 ~ 20% of polyhedral organic silsesquioxane.

Further, the invention relates to a medical polymer composition easy to weld, which comprises, by weight, 30-60% of polylactic acid, 7.9-9% of styrene-maleic anhydride-cycloolefin copolymer, 20-50% of propylene-ethylene block copolymer and 12.1 ~ 20% of polyhedral organic silsesquioxane.

Ultrasonic welding is to transmit ultrasonic energy to the welding zone through the upper weldment, and the joint surface of the hose and the connecting piece is subjected to friction heat and instant fusion joint by utilizing the large acoustic resistance of the interface of the two welds to generate local high temperature, so that the welding strength is high, watertight and airtight can be achieved, inconvenience caused by adopting auxiliary products is avoided, and efficient and clean welding is realized. The welding technique is a high-tech technique for welding thermoplastic plastic products, and can completely replace the gluing technique. Various thermoplastic pieces can be treated using ultrasonic welding techniques without the need for solvents, adhesives, or other aids. The welding head vibrating with ultrasonic wave and superhigh frequency makes the two plastic joint surfaces produce friction heat and instantaneous fusion joint under proper pressure, and has welding strength comparable to that of the main body, proper work piece and reasonable interface design to reach watertight and airtight performance, avoid the inconvenience of auxiliary product and realize high efficiency and clean welding.

Laser plastic welding is also known as laser penetration welding or penetration IR welding. The principle is that laser penetrates through transparent plastic and is converted into heat at a heat absorption joint surface, and because two welded materials are pressed together in the welding process and the heat joint surface conducts, the two materials are melted and jointed together, and meanwhile, the inside can generate local temperature rise and pressure. The externally and internally generated pressure is the condition required to form a good weld. The technique of bonding thermoplastic sheets, films or molded parts together by melting the plastic contact surface with the heat generated by a laser beam. It was first in the 70's of the 20 th century but, because of its high cost, it was not competitive with earlier plastic bonding techniques, such as vibration welding, hot plate welding. However, since the mid-90 s of the 20 th century, the laser welding technique has become increasingly popular due to the reduction in the cost of equipment required.

The Si-O bonds of the POSS in the composition of the invention promote the heat absorption of the material, thereby facilitating ultrasonic and laser welding. Solvent welding is to dip coat the surfaces of the hose and connector with tetrahydrofuran and then to attach the tetrahydrofuran coated surfaces to each other, giving the appropriate pressure and temperature. Because POSS tends to be uniformly enriched on the surface of the material in the processing process, the POSS rich in organic functional groups can be dissolved in organic solvents such as tetrahydrofuran and the like under certain pressure and temperature, so that the composite material can be welded with a connecting piece through the solvent.

although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.

Claims

1. The medical polymer composition easy to weld and the preparation method thereof are characterized by comprising, by weight, 20-80% of polylactic acid, 1.9-10% of styrene-maleic anhydride-cycloolefin copolymer, 10-70% of propylene-ethylene block copolymer and 8.1 ~ 20% of polyhedral organic silsesquioxane.

2. The easily weldable medical polymer composition and the preparation method thereof according to claim 1, wherein the composition comprises, by weight, 30-60% of polylactic acid, 7.9-9% of styrene-maleic anhydride-cycloolefin copolymer, 20-50% of propylene-ethylene block copolymer, and 12.1 ~ 20% of polyhedral organic silsesquioxane.

3. The method for preparing a medical polymer composition easy to weld according to claim 1, wherein the weighed polylactic acid, styrene-maleic anhydride-cycloolefin copolymer, propylene-ethylene block copolymer and polyhedral organic silsesquioxane are mixed and extruded by a twin-screw extruder to be pelletized.