CN110548051A - Skin cell repairing spray suitable for astronauts - Google Patents
Skin cell repairing spray suitable for astronauts Download PDFInfo
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- CN110548051A CN110548051A CN201810543491.2A CN201810543491A CN110548051A CN 110548051 A CN110548051 A CN 110548051A CN 201810543491 A CN201810543491 A CN 201810543491A CN 110548051 A CN110548051 A CN 110548051A
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- Prior art keywords
- chlorella
- collagen
- skin cell
- amino acids
- astronauts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
Abstract
The invention discloses a skin cell repairing spray suitable for astronauts, which comprises the following raw materials: chlorella extract, collagen amino acids, and ethanol. The chlorella collagen protein takes chlorella extract and collagen amino acids as raw materials, is green and natural, is convenient to use, has no toxic or side effect, is particularly rich in active substances such as chlorella growth factors, collagen amino acids and the like, has the effects of sterilization, inflammation diminishing, oxidation resistance and the like, and can promote the repair of skin cells after light radiation damage.
Description
Technical Field
the invention relates to a skin cell repairing spray, in particular to a skin cell repairing spray suitable for astronauts.
Background
After the breakthrough of manned technology is realized, the manned space engineering in China gradually enters the era of space stations, the time of the spaceman staying in the space is gradually increased, and the manned space technology also faces the problem of how to guarantee the long-term life of the spaceman in the space environment because the spaceman needs to face the severe environments of weightlessness, radiation, space-time disorder and the like in the space. Among them, the space radiation environment is an important cause of health hazards for astronauts, and has a great influence on safety of astronauts during tasks. The space environment radiation mainly comprises a Galaxy cosmic ray, solar high-energy particles and radiation zone particles in an abnormal region of the southern Atlantic region. Generally, a large amount of high-energy protons, electrons and heavy ions exist in the near-earth space where the astronaut is located, which can cause radiation injury to the astronaut in orbit, and especially when the astronaut leaves the capsule, the radiation can cause the accumulated dose in the astronaut to exceed the maximum safe radiation dose allowed in one year in a short time, which causes the injury to cells, tissues, organs and the like of the human body
research shows that the early effect of space radiation environment on human body is shown as direct damage caused by ionization, such as blood function reduction, skin erythema, depilation, reproductive dysfunction and the like, and usually the first symptoms appear in parts of digestive system, blood system, skin and the like. The skin, the largest organ of the human body, is in direct contact with the external environment and is one of the major target organs for the action of ultraviolet rays. In the space radiation environment, the skin damage degree mainly depends on the irradiation dose, the skin damage is more serious when the irradiation dose is larger, and if the irradiation dose reaches 400-800 rads, erythema can appear on the skin within hours to one day after irradiation. In order to reduce the damage of the space radiation environment to astronauts, physical shielding layers can be generally adopted for protection, such as bulkheads of spacecrafts, space suits and the like, and radiation protection medicines can be used for enhancing the capacity of resisting space radiation or improving the repair speed of radiation damage parts after the radiation protection medicines return to the earth.
Disclosure of Invention
Aiming at the problems, the invention provides the skin cell repairing spray suitable for astronauts, which is prepared by adopting chlorella extract and collagen amino acids as raw materials, is green and natural, is convenient to use, has no toxic or side effect, is particularly rich in active substances such as chlorella growth factors, collagen amino acids and the like, has the effects of sterilization, inflammation diminishing, oxidation resistance and the like, and can promote the repair of skin cells after light radiation damage.
The invention is realized by the following technical scheme.
A skin cell repairing spray suitable for astronauts is characterized by comprising the following raw materials: chlorella extract, collagen amino acids, and ethanol.
As a preferred technical scheme, the raw materials comprise the following components in percentage by weight: 0.1 to 5 percent of chlorella extract, 0.1 to 5 percent of collagen amino acids and the balance of ethanol.
as a preferred technical scheme, the chlorella extract is prepared by adopting the following method:
1) Enzymolysis: mixing chlorella powder with warm water according to the feed liquid mass ratio of 1: 2-4 kg/kg, soaking for 2-4 h, adding pectinase and cellulase, and performing enzymolysis at the pH of 5-6 and the temperature of 25-30 ℃ for 30-60 min to obtain chlorella enzymatic hydrolysate; through the step, the cell wall structure of the chlorella powder can be destroyed by enzymolysis, and the release of intracellular nutritional active ingredients in the chlorella powder is facilitated;
2) High-pressure negative-pressure treatment: transferring the chlorella enzymolysis liquid into a high-pressure-resistant container, pressurizing to 80-200 MPa, then instantly reducing the pressure to 0.50-0.85 MPa within 2s, then centrifuging the chlorella enzymolysis liquid, and respectively collecting supernatant and lower-layer precipitates; specifically, this step may be performed by a differential pressure bulking device; by the high-pressure negative-pressure treatment in the step, the formed larger pressure difference inside and outside the cell can be utilized to enable the cytoplasm containing the active substances in the cell to flow rapidly, so that the extraction time of the active substances is reduced, and the yield of the chlorella extract is improved;
3) Low-temperature slow freezing-low-power intermittent microwave thawing treatment: slowly freezing the lower-layer precipitate at the temperature of-2 to-8 ℃, then freezing at the temperature of-18 to-60 ℃ for 12 to 36 hours, then carrying out low-power intermittent microwave thawing under the conditions that the microwave power is 0.1 to 1kw/kg, the microwave intermittent time is 10 to 30s and the microwave working time is 30 to 60s until the lower-layer precipitate is completely thawed, and collecting a thawing solution for later use; through the step, the active substances which are difficult to extract by the conventional method or the active ingredients remained in the waste (such as the lower layer sediment in the step 2) can be extracted and enriched along with the flowing of the unfrozen juice by utilizing the further damage of the plant tissue to the cells of the plant tissue in the slow freezing and unfreezing processes of the plant tissue, so that the yield of the chlorella extract can be greatly improved;
4) And (3) drying: mixing the supernatant obtained in the step (2) and the unfrozen liquid obtained in the step (3), concentrating and drying to obtain a chlorella extract;
In the steps, the combination of enzymolysis, high-pressure negative-pressure treatment, low-temperature slow freezing and low-power intermittent microwave thawing treatment can greatly improve the extraction yield and the content level of active ingredients of a final product so as to prepare a high-quality chlorella extract raw material.
Preferably, the collagen amino acids are amino acid products obtained by hydrolyzing collagen.
as a preferred technical scheme, the amino acid product comprises glycine, alanine, glutamic acid, arginine and cysteine.
Preferably, the collagen amino acids are prepared by the following method: dissolving collagen with warm water according to the mass ratio of 1: 5-7 of feed liquid, adding pepsin, trypsin and proteinase K, and carrying out heat preservation and enzymolysis for 2-4 hours at the temperature of 30-35 ℃; then treating the enzymolysis liquid for 2-3 times at 150-200 MPa by adopting a nano collider, and inactivating enzyme by utilizing ultrahigh pressure and further hydrolyzing the polypeptide in the hydrolysis liquid; and then, carrying out ultrafiltration by adopting an ultrafiltration membrane with the molecular weight cutoff of 2 ten thousand daltons, collecting filtrate for dialysis, and carrying out freeze drying on a dialyzed product to obtain the collagen amino acid.
According to a preferable technical scheme, the collagen is deep sea fish skin collagen.
The invention has the beneficial effects that:
1) The product of the invention is rich in chlorella growth factors, which are also called chlorella essence, are cell active substances, comprise amino acids, nucleic acids, polysaccharides, polypeptides, proteins, enzymes, vitamins, mineral substances and 'mysterious components', are called 'hormone-like', and have the functions of activating lymphocytes, enhancing the immunity of human bodies, activating human cells, promoting the repair of injured tissues of human bodies, resisting ultraviolet injury to skin and the like; the collagen amino acid as another active substance in the product can promote the repair of damaged skin, delay skin aging, accelerate wound healing and improve skin appearance; therefore, the product of the invention can be used for daily skin care such as sterilization, inflammation diminishing, oxidation resisting and the like, and can also be used for repairing skin cells damaged by ultraviolet radiation and the like.
2) The product of the invention is a spray product which takes natural, green and safe chlorella extract and collagen amino acids as raw materials and takes ethanol as a carrier, and the spray product does not contain antiseptic and hormone components, is mild, has no stimulation to skin, is convenient to use and has long storage time.
Detailed Description
The present invention will be further described with reference to the following detailed description, which should be construed as illustrative only, and not limiting the scope of the invention, which is to be given the full breadth of the appended claims, and all changes that can be made by those skilled in the art and which are, therefore, intended to be embraced therein.
Example 1
A skin cell repairing spray suitable for astronauts is prepared from the following raw materials: chlorella extract, collagen amino acids, and ethanol.
Example 2
A skin cell repairing spray suitable for astronauts comprises the following raw materials in percentage by weight: 0.1 to 5 percent of chlorella extract, 0.1 to 5 percent of collagen amino acids and the balance of ethanol.
Example 3
a skin cell repairing spray suitable for astronauts is prepared from the following raw materials: chlorella extract, collagen amino acids, and ethanol; wherein, the chlorella extract is prepared by the following method:
1) Enzymolysis: mixing chlorella powder with warm water according to the feed liquid mass ratio of 1: 2-4 kg/kg, soaking for 2-4 h, adding pectinase and cellulase, and performing enzymolysis at the pH of 5-6 and the temperature of 25-30 ℃ for 30-60 min to obtain chlorella enzymatic hydrolysate;
2) High-pressure negative-pressure treatment: transferring the chlorella enzymolysis liquid into a high-pressure-resistant container, pressurizing to 80-200 MPa, then instantly reducing the pressure to 0.50-0.85 MPa within 2s, then centrifuging the chlorella enzymolysis liquid, and respectively collecting supernatant and lower-layer precipitates;
3) low-temperature slow freezing-low-power intermittent microwave thawing treatment: slowly freezing the lower-layer precipitate at the temperature of-2 to-8 ℃, then freezing at the temperature of-18 to-60 ℃ for 12 to 36 hours, then carrying out low-power intermittent microwave thawing under the conditions that the microwave power is 0.1 to 1kw/kg, the microwave intermittent time is 10 to 30s and the microwave working time is 30 to 60s until the lower-layer precipitate is completely thawed, and collecting a thawing solution for later use;
4) And (3) drying: and (3) mixing the supernatant obtained in the step (2) with the unfrozen liquid obtained in the step (3), concentrating and drying to obtain the chlorella extract.
Example 4
A skin cell repairing spray suitable for astronauts is prepared from the following raw materials: chlorella extract, collagen amino acids, and ethanol; wherein, the collagen amino acid is prepared by the following method: dissolving collagen with warm water according to the mass ratio of 1: 5-7 of feed liquid, adding pepsin, trypsin and proteinase K, and carrying out heat preservation and enzymolysis for 2-4 hours at the temperature of 30-35 ℃; then treating the enzymolysis liquid for 2-3 times at 150-200 MPa by adopting a nano collider, and inactivating enzyme by utilizing ultrahigh pressure and further hydrolyzing the polypeptide in the hydrolysis liquid; and then, carrying out ultrafiltration by adopting an ultrafiltration membrane with the molecular weight cutoff of 2 ten thousand daltons, collecting filtrate for dialysis, and carrying out freeze drying on a dialyzed product to obtain the collagen amino acid.
Claims (7)
1. A skin cell repairing spray suitable for astronauts is characterized by comprising the following raw materials: chlorella extract, collagen amino acids, and ethanol.
2. the skin cell repair spray suitable for astronauts as claimed in claim 1, wherein the raw materials comprise, by weight: 0.1 to 5 percent of chlorella extract, 0.1 to 5 percent of collagen amino acids and the balance of ethanol.
3. The skin cell repair spray suitable for astronauts of claim 1, wherein the chlorella extract is prepared by the following method:
1) Enzymolysis: mixing chlorella powder with warm water according to the feed liquid mass ratio of 1: 2-4 kg/kg, soaking for 2-4 h, adding pectinase and cellulase, and performing enzymolysis at the pH of 5-6 and the temperature of 25-30 ℃ for 30-60 min to obtain chlorella enzymatic hydrolysate;
2) high-pressure negative-pressure treatment: transferring the chlorella enzymolysis liquid into a high-pressure-resistant container, pressurizing to 80-200 MPa, then instantly reducing the pressure to 0.50-0.85 MPa within 2s, then centrifuging the chlorella enzymolysis liquid, and respectively collecting supernatant and lower-layer precipitates;
3) low-temperature slow freezing-low-power intermittent microwave thawing treatment: slowly freezing the lower-layer precipitate at the temperature of-2 to-8 ℃, then freezing at the temperature of-18 to-60 ℃ for 12 to 36 hours, then carrying out low-power intermittent microwave thawing under the conditions that the microwave power is 0.1 to 1kw/kg, the microwave intermittent time is 10 to 30s and the microwave working time is 30 to 60s until the lower-layer precipitate is completely thawed, and collecting a thawing solution for later use;
4) And (3) drying: and (3) mixing the supernatant obtained in the step (2) with the unfrozen liquid obtained in the step (3), concentrating and drying to obtain the chlorella extract.
4. the skin cell repair spray suitable for use by an astronaut according to claim 1, wherein the collagen amino acids are amino acid products obtained by hydrolyzing collagen.
5. The skin cell repair spray suitable for use by an astronaut according to claim 4, wherein the amino acid product comprises glycine, alanine, glutamic acid, arginine, cysteine.
6. A skin cell repair spray for use by an astronaut according to any one of claims 1 to 5, wherein the collagen amino acids are prepared by the following method: dissolving collagen with warm water according to the mass ratio of 1: 5-7 of feed liquid, adding pepsin, trypsin and proteinase K, and carrying out heat preservation and enzymolysis for 2-4 hours at the temperature of 30-35 ℃; then treating the enzymolysis liquid for 2-3 times at 150-200 MPa by adopting a nano collider, and inactivating enzyme by utilizing ultrahigh pressure and further hydrolyzing the polypeptide in the hydrolysis liquid; and then, carrying out ultrafiltration by adopting an ultrafiltration membrane with the molecular weight cutoff of 2 ten thousand daltons, collecting filtrate for dialysis, and carrying out freeze drying on a dialyzed product to obtain the collagen amino acid.
7. The skin cell repair spray suitable for use by an astronaut according to claim 6, wherein the collagen is deep sea fish skin collagen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810543491.2A CN110548051A (en) | 2018-05-30 | 2018-05-30 | Skin cell repairing spray suitable for astronauts |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810543491.2A CN110548051A (en) | 2018-05-30 | 2018-05-30 | Skin cell repairing spray suitable for astronauts |
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| CN110548051A true CN110548051A (en) | 2019-12-10 |
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| CN201810543491.2A Pending CN110548051A (en) | 2018-05-30 | 2018-05-30 | Skin cell repairing spray suitable for astronauts |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1360847A (en) * | 2000-12-25 | 2002-07-31 | 暨南大学 | Prepn of chlorella extract |
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| CN103388017A (en) * | 2013-08-06 | 2013-11-13 | 国家海洋局第三海洋研究所 | Preparation technology of fish skin collagen oligopeptide |
| CN103555582A (en) * | 2013-10-22 | 2014-02-05 | 渤海大学 | Method for breaking wall of chlorella by using compound enzyme |
| CN104152518A (en) * | 2014-05-14 | 2014-11-19 | 浙江海洋学院 | Preparation method of hepatopathy complementary-food cod skin collagen peptide |
| CN106191189A (en) * | 2016-09-20 | 2016-12-07 | 武汉百思凯瑞纳米科技有限公司 | A kind of preparation method and applications of tuna skin height moisturizing bioactive peptide |
| CN106236623A (en) * | 2016-07-29 | 2016-12-21 | 上海伽誉生物科技有限公司 | The preparation method of chlorella deep layer purification factor |
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2018
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| CN104152518A (en) * | 2014-05-14 | 2014-11-19 | 浙江海洋学院 | Preparation method of hepatopathy complementary-food cod skin collagen peptide |
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Application publication date: 20191210 |