CN110522797A - Charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism - Google Patents
Charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism Download PDFInfo
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Abstract
It is the drug for the treatment of and enteric flora disturbance related disease that the present invention, which provides a kind of charred RADIX ET RHIZOMA RHEI adjusting the application of purposes and charred RADIX ET RHIZOMA RHEI in enteric microorganism in medicine preparation, the drug,.
Description
Technical field
The invention belongs to medicines and health protection fields, and in particular to a kind of charred RADIX ET RHIZOMA RHEI is improving and adjusting the use in enteric microorganism
On the way.
Background technique
Human body endosymbiosis a large amount of microorganisms, especially have about 100,000,000,000,000 bacterium of 1000-1150 kind in human body intestinal canal, be people
Body is most important " endogenous cycle border factor ", and number is 10 times or so of human body own cells number.Under normal circumstances, enteron aisle
Microorganism is in the ecological environment of a dynamic equilibrium, and normal flora not only plays not in digestion, immune and anti-virus aspect
Alternative effect, and the change of enteric microorganism is especially some chronic diseases with body health or disease and has
Extremely close relationship.Under contemporary society's environment, people's great work intensity, life stress is big, human body be chronically at it is various stress
State can frequently result in enteric microorganism imbalance, show as enteric microorganism on type, quantity, ratio and biological characteristics
Anomalous variation.Flora imbalance weakens the barrier function of enteron aisle by influencing body to the absorption of nutriment in turn again, into
One step aggravates disease, and forms a kind of vicious circle.Research confirmation, a variety of diseases of human body such as long-term diarrhea, constipation, enteritis
The morbidity of disease, digestive tract ulcer, diabetes, hypertension, hyperlipidemia, tumour etc. is all closely related with enteric microorganism.Although mesh
Actually the variation of preceding not clear intestinal microflora causes the generation of metabolism class disease, or the hair of metabolism class disease
The raw variation for resulting in intestinal microflora, but have any that can affirm: the composition by changing intestinal microflora,
The health of human body is had an impact, while help may also be provided to the treatment of certain diseases.Currently, enteric microorganism is recognized
For the possibility therapeutic targets for being a variety of diseases.
Patent document CN 106620189A provides a kind of method for improving enteric microorganism structure, and its is preparing medicine
Application during object, nutriment, health care product, food, beverage etc..The invention is used based on high throughput sequencing technologies and changeable
Amount statistical method has found the enteric bacteria monoid closely related with host metabolism, the bacterium as produced short chain fatty acids in enteron aisle
It is mostly beneficial bacterium, anti-inflammatory, protection intestinal barrier function, adjusting can be played by increasing the content of enteron aisle Short-Chain Fatty Acids
Body metabolism and it is immune the effects of.Short chain fatty acids producing strains include Blaw spy Bordetella, Allobaculum, general Bordetella, intend
Bacillus or Butyricimonas.It is mostly harmful bacteria that endotoxic bacterium is produced in enteron aisle, can be by increasing in enteron aisle
Content of toxins causes inflammation, damages intestinal barrier function, causes the effects of body metabolism and immune disorder.Generate endotoxic bacterium
Bacterium including Proteobacteria.
So far, the intestinal beneficial bacterium that scientist has found generally can be divided into three categories, including: lactobacillus class
(such as lactobacillus acidophilus, Lactobacillus casei, Lactobacillus Jensenii, Raman lactobacillus)；Bifidobacterium class (such as bifidobacterium longum, short
Bifidobacterium, oval Bifidobacterium, bifidobacterium thermophilum etc.)；Gram-positive cocci (such as streptococcus fecalis, galactococcus, intermediary's chain
Coccus etc.).
Human biology be it is dimerous by human genome and human microorganism's group, wherein human genome changes
Change is extremely difficult, but the change that microorganism is constituted in human body intestinal canal is relatively easy.High caloric diet, fast section at present
Life is played, so that the case where enteric microorganism disorder occurs in some people, removes nonemergency, majority can select to pass through diet
It is adjusted, existing research shows the micro- life of enteron aisle of the adjustable human body of the food of some Chinese medicines and some integration of drinking and medicinal herbs or animal
Object.The purposes in enteric microorganism is being adjusted as patent document CN 105596445A is related to root bark of tree peony radix paeoniae rubra, inventor, which studies, to be sent out
Existing, root bark of tree peony radix paeoniae rubra not only adjustable enteric microorganism, and no any side effect can take for a long time.For another example patent document
CN 102987383B provides a kind of composition by integration of drinking and medicinal herbs food composition, and the composition can be used for balancing in main body
Enteric microorganism structure improves metabolic syndrome.
In the present invention, can inventor adjust enteric microorganism to charred RADIX ET RHIZOMA RHEI and do correlative study.Charred RADIX ET RHIZOMA RHEI is Chinese medicine
The Preparation process product of material rheum officinale, for purging heat logical intestines in clinic, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.Rheum officinale may be from sorrel
(Rheum palmatum L.), Rheum officinale (Rheum offcinale Baill.), Rheum tanguticum Maxim (Rheum
Tanguticum Maxim.ex Balf.) dry root and rhizome.Patent document CN103251913A discloses a kind of for protecting
The Chinese medicine composition of gastrointestinal tract of livestock and fowls is protected, the Chinese medicine composition includes charred RADIX ET RHIZOMA RHEI, it can be effectively protected the gastrointestinal tract of livestock and poultry,
And to the other organs of livestock and poultry it is without any side effects and damage, and inventor there is no just the Chinese medicine composition protection livestock and poultry stomach and intestine
The action principle in road do deeper into research.Charred RADIX ET RHIZOMA RHEI is chiefly used in anastalsis at present, rarely has about charred RADIX ET RHIZOMA RHEI to human body or dynamic
The research report that object enteric microorganism influences, in the present invention, inventor is with regard to charred RADIX ET RHIZOMA RHEI and includes the Chinese medicine composition of charred RADIX ET RHIZOMA RHEI
Careful research has been done to human body or animal intestinal tract microbiological effect.
Summary of the invention
In the present invention, inventor inhibits simultaneously the study found that charred RADIX ET RHIZOMA RHEI can significantly improve the quantity of beneficial bacterium in enteron aisle
Enteric microorganism is adjusted in the quantity of harmful bacteria.The research about charred RADIX ET RHIZOMA RHEI in terms of adjusting enteric microorganism is had no at this stage
And report.
Therefore, it is an object of the present invention to provide a kind of charred RADIX ET RHIZOMA RHEIs to adjust the purposes in enteric microorganism.The present invention
A further object is and a kind of application of charred RADIX ET RHIZOMA RHEI in medicine preparation is provided, the drug be treat it is related to enteric flora disturbance
The drug of disease.Another object of the present invention is to provide a kind of composition comprising charred RADIX ET RHIZOMA RHEI and is adjusting the use in enteric microorganism
On the way.The present invention, which a further object is, provides a kind of application of the composition comprising charred RADIX ET RHIZOMA RHEI in medicine preparation, and the drug is
The drug for the treatment of and enteric flora disturbance related disease.
The present invention provides a kind of charred RADIX ET RHIZOMA RHEI and is adjusting the purposes in enteric microorganism.
The purposes in enteric microorganism is being adjusted according to the charred RADIX ET RHIZOMA RHEI, can be bacterium in selective increase enteron aisle
Quantity, the bacterium is selected from: lactobacillus (Lactobacillus), pseudomonas (Pseudomonas), streptomyces
(Streptomyces), mycobacterium (Mycobacterium), acinetobacter (Acinetobacter), lactococcus
(Lactococcus), Helicobacterium (Helicobacter), Brevibacillus (Brevibacillus), staphylococcus
(Staphylococcus), marinobacter (Marinobacter), Treponema (Treponema), enlightening thatch Pseudomonas
(Dietzia), Bacteroides (Bacteroides), Burkholderia (Burkholderia), Rhod
(Rhodococcus), fusobacterium (Clostridium), paracoccus (Paracoccus), in dark Bacillus (Pelobacter)
A combination of one or more；
Preferably, the bacterium is selected from: lactobacillus, pseudomonas, acinetobacter, Helicobacterium, treponema
The combination of one or more of category, fusobacterium；
It is furthermore preferred that the bacterium is selected from: Pseudomonas sp.TAD18, Pseudomonas formosensis,
Streptomyces sp.NRRL WC-3703、Streptomyces novaecaesareae、Streptomyces
griseorubens、Mycobacterium sp.852002-51759_SCH5129042、Lactobacillus
sp.UMNPBX14、Lactobacillus sp.UMNPBX16、Lactobacillus sp.HMSC24D01、
Lactobacillus reuteri、Lactobacillus sp.UMNPBX10、Lactobacillus sp.UMNPBX18、
Lactobacillus frumenti、Lactobacillus sp.UMNPBX3、Lactobacillus vaginalis、
Lactobacillus sp.UMNPBX13、Lactobacillus sp.UMNPBX5、Lactobacillus
sp.Marseille-P3519、Lactobacillus sp.UMNPBX7、Lactobacillus antri、Lactobacillus
oris、Lactobacillus pontis、Lactobacillus animalis、Lactobacillus mucosae、
Lactobacillus murinus、Lactobacillus apodemi、Lactobacillus coleohominis、
Lactobacillus salivarius、Lactobacillus fermentum、Lactobacillus sp.UMNPBX2、
Lactobacillus panis、Lactobacillus saerimneri、Lactobacillus sp.UMNPBX9、
Lactobacillus equigenerosi、Lactobacillus sp.UMNPBX1、Lactobacillus
selangorensis、Lactobacillus agilis、Lactobacillus sp.ASF360、Lactobacillus
sp.7_1_47FAA、Lactobacillus gallinarum、Lactobacillus acidophilus、Lactobacillus
hayakitensis、Lactobacillus intestinalis、Lactobacillus ceti、Lactobacillus
kefiranofaciens、Lactobacillus amylolyticus、Lactobacillus acidipiscis、
Lactobacillus acetotolerans、Acinetobacter sp.25977_10、Acinetobacter
sp.259052、Acinetobacter sp.796380-1375、Acinetobacter sp.25977_7、Lactococcus
sp.DD01、Lactococcus petauri、Helicobacter typhlonius、Helicobacter hepaticus、
Helicobacter sp.TUL、Helicobacter japonicus、Helicobacter jaachi、Helicobacter
sp.11S02596-1、Helicobacter saguini、Helicobacter bizzozeronii、Helicobacter
sp.MIT 03-1616、Helicobacter himalayensis、Helicobacter sp.MIT 11-5569、
Helicobacter fennelliae、Helicobacter sp.CLO-3、Helicobacter canis、Helicobacter
bilis、Helicobacter cetorum、Helicobacter sp.13S00401-1、Helicobacter apodemus、
Helicobacter sp.MIT 01-6242、Helicobacter rodentium、Helicobacter mustelae、
Helicobacter macacae、Helicobacter sp.MIT 05-5293、Helicobacter sp.11S03491-1、
Helicobacter ailurogastricus、Helicobacter pullorum、Helicobacter canadensis、
Helicobacter sp.12S02634-8、Helicobacter magdeburgensis、Helicobacter
winghamensis、Brevibacillus sp.CF112、Staphylococcus sp.HMSC061F10、Marinobacter
sp.C1S70、Marinobacter manganoxydans、Marinobacter sp.YWL01、Treponema sp.JC4、
Treponema porcinum、Treponema sp.C6A8、Treponema saccharophilum、Treponema
bryantii、Treponema succinifaciens、Treponema socranskii、Treponema
brennaborense、Dietzia sp.111N12-1、Dietzia sp.UCD-THP、Bacteroides sp.3_1_23、
Bacteroides sp.3_1_19、Burkholderia sp.2002721687、Burkholderia sp.A27、
Rhodococcus sp.06-1477-1B、Clostridium sp.IBUN125C、Clostridium tepidum、
Clostridium sp.ATCC 25772、Clostridium sp.HMSC19D07、Paracoccus sanguinis、
The combination of one or more of Pelobacter propionicus, Pelobacter acetylenicus.
The purposes in enteric microorganism is being adjusted according to the charred RADIX ET RHIZOMA RHEI, can be bacterium in selective inhibition enteron aisle
Quantity, the bacterium is selected from: secondary bar shape Pseudomonas (Parabacteroides), bacillus genus (Paenibacillus),
Campylobacter (Campylobacter), Enterobacter (Enterobacter), Ruminococcus (Ruminococcus), fibre
Tie up Bacillus (Fibrobacter), streptococcus (Streptococcus), Nostoc (Nostoc), Selenomonas
(Selenomonas), Anaerovibrio (Anaerovibrio), hemophilus (Haemophilus), Brachyspira
(Brachyspira), enterococcus spp (Enterococcus), Escherichia (Escherichia), raw rhizobium
(Mesorhizobium), one or both of bacillus (Bacillus), bud zygosaccharomyces (Blastomonas) with
On combination；
Preferably, the bacterium is selected from: secondary bar shape Pseudomonas, bacillus genus, campylobacter, Cellulomonas, chain
The combination of one or more of Coccus, enterococcus spp；
It is furthermore preferred that the bacterium is selected from: Parabacteroides sp.D25, Parabacteroides
distasonis、Paenibacillus sp.RUD330、Paenibacillus sp.FSL R5-808、Campylobacter
sp.110、Campylobacter coli、Enterobacter sp.BIDMC94、Enterobacter sp.NFIX09、
Ruminococcus sp.DSM 100440、Fibrobacter sp.UWH5、Fibrobacter sp.UWCM、
Fibrobacter sp.UWH9、Fibrobacter sp.UWH1、Fibrobacter sp.UWS1、Fibrobacter
sp.UWOS、Streptococcus sp.HMSC066F01、Streptococcus sp.45、Streptococcus suis、
Streptococcus sp.HMSC064D12、Streptococcus sp.HMSC067A03、Streptococcus
lutetiensis、Streptococcus infantarius、Streptococcus sp.NPS 308、Streptococcus
sp.CM7、Streptococcus caballi、Streptococcus sp.HMSC066E07、Streptococcus
sp.HMSC065H07、Streptococcus sp.HMSC36C04、Streptococcus sp.HMSC061D01、Nostoc
sp.NIES-4103、Nostoc calcicola、Selenomonas sp.FOBRC6、Anaerovibrio lipolyticus、
Anaerovibrio sp.RM50、Anaerovibrio sp.JC8、Haemophilus sputorum、Brachyspira
pilosicoli、Enterococcus avium、Enterococcus sp.HMSC034B11、Escherichia sp.1_1_
43、Mesorhizobium sp.NBIMC_P2-C2、Bacillus sp.FJAT-14266、Blastomonas sp.CCH4-
The combination of one or more of D12.
The purposes in enteric microorganism is being adjusted according to the charred RADIX ET RHIZOMA RHEI, can be fungi in selective inhibition enteron aisle
Quantity, the virus is selected from: aspergillus flavus (Aspergillus flavus).
The present invention provides a kind of application of charred RADIX ET RHIZOMA RHEI in medicine preparation, and the drug is treatment and enteric flora disturbance phase
The drug of related disorders, it is preferred that the disease is selected from: long-term diarrhea, constipation, obesity, food hypersenstivity, pancreatitis, hepatic injury,
It includes gestational diabetes, class that intestinal inflammatory, which includes Crohn disease, irritable bowel syndrome, digestive tract ulcer, kidney stone, diabetes,
Rheumatic arthritis, Behcet's disease, cardiovascular disease, cranial vascular disease include apoplexy, tumour, paralysis, eye disease, multiple sclerosis
Disease, ankylosing spondylitis, parkinsonism, anxiety, self-closing disease, depression, chronic fatigue syndrome.
The present invention provides a kind of composition comprising charred RADIX ET RHIZOMA RHEI and is adjusting the purposes in enteric microorganism.
The purposes in enteric microorganism is being adjusted according to the composition comprising charred RADIX ET RHIZOMA RHEI, can be selective increasing
Add the quantity of bacterium in enteron aisle, the bacterium is selected from: lactobacillus (Lactobacillus), mycobacterium
(Mycobacterium), microballoon Caulobacter (Microbulbifer), Cellulomonas (Fibrobacter), Rhod are produced
(Rhodococcus), methane brevibacterium (Methanobrevibacter), acinetobacter (Acinetobacter), close spiral
Body category (Treponema), Nostoc (Nostoc), Bacteroides (Bacteroides), the thin end of the scroll Pseudomonas (Pedobacter),
Fusobacterium (Clostridium), pseudomonas (Pseudomonas), Bifidobacterium (Bifidobacterium), Pu Shi
Pseudomonas (Prevotella), Eubacterium (Eubacterium), bacillus (Bacillus), Burkholderia
(Burkholderia), Ruminococcus (Ruminococcus), Selenomonas (Selenomonas), sulphur Microspira
(Thiomicrospira), excrement gemma Pseudomonas (Coprobacillus), Enterobacter (Enterobacter), thin layer Pseudomonas
(Hymenobacter), one of the gloomy Bordetella in Continental Europe (Olsenella), Collins Bordetella (Collinsella) or two
Kind or more combination；
Preferably, the bacterium is selected from: lactobacillus, Cellulomonas, Bacteroides, fusobacterium, Bifidobacterium, Europe
The combination of one or more of Lu Sen Bordetella, Collins Bordetella；
It is furthermore preferred that the bacterium is selected from: Lactobacillus sp.UMNPBX11, Lactobacillus
sp.HMSC24D01、Lactobacillus sp.UMNPBX10、Lactobacillus vaginalis、Lactobacillus
sp.UMNPBX7、Lactobacillus reuteri、Lactobacillus sp.UMNPBX18、Lactobacillus
sp.UMNPBX3、Lactobacillus johnsonii、Lactobacillus frumenti、Lactobacillus
sp.UMNPBX19、Lactobacillus sp.7_1_47FAA、Lactobacillus sp.UMNPBX6、Lactobacillus
sp.ASF360、Mycobacterium sp.GA-2945b、Mycobacterium sp.852002-51759_SCH5129042、
Microbulbifer sp.WRN-8、Fibrobacter sp.UWH3、Fibrobacter sp.UWS1、Fibrobacter
sp.UWOS、Fibrobacter sp.UWH9、Fibrobacter sp.UWR3、Fibrobacter sp.UWB15、
Fibrobacter sp.UWT3、Fibrobacter sp.UWB1、Rhodococcus sp.06-156-4C、
Methanobrevibacter smithii、Acinetobacter sp.796380-1375、Acinetobacter
sp.259052、Acinetobacter sp.72431、Treponema succinifaciens、Treponema
saccharophilum、Nostoc sp.NIES-4103、Nostoc calcicola、Bacteroides sp.D1、
[Bacteroides]pectinophilus、Pedobacter himalayensis、Clostridium bornimense、
Clostridium autoethanogenum、Clostridium sp.HMSC19B01、Clostridium saudiense、
Clostridium sartagoforme、Pseudomonas sp.M1、Lachnoclostridium sp.An76、Bacillus
subtilis、Bacillus sp.FJAT-14266、Burkholderia sp.2002721687、Ruminococcus
sp.YE71、Ruminococcus champanellensis、Ruminococcus bromii、Ruminococcus
sp.FC2018、Ruminococcus sp.NK3A76、Selenomonas flueggei、Selenomonas sp.oral
taxon 920、Selenomonas sp.oral taxon 126、Selenomonas sp.oral taxon 892、
Selenomonas sp.FOBRC6、Thiomicrospira microaerophila、Coprobacillus sp.3_3_
56FAA、Coprobacillus sp.8_1_38FAA、Enterobacter sp.ST121:950178628、Enterobacter
sp.BIDMC93、Hymenobacter swuensis、[Eubacterium]siraeum、[Eubacterium]hallii、
[Eubacterium]rectale、Eubacterium ventriosum、Eubacterium aggregans、Eubacterium
sp.68-3-10、Eubacterium sp.AB3007、Olsenella sp.DNF00959、Olsenella sp.oral
taxon 809、Olsenella sp.An285、Olsenella sp.An290、Olsenella sp.Marseille-P2912、
Olsenella uli、Olsenella sp.KH1P3、Olsenella sp.An293、Olsenella sp.An188、
Olsenella sp.kh2p3、Olsenella sp.An270、Olsenella umbonata、Olsenella
sp.Marseille-P2300、Olsenella sp.KH3B4、Olsenella urininfantis、Olsenella
scatoligenes、Olsenella sp.Marseille-P3256、Olsenella sp.HMSC062G07、Collinsella
sp.An271、Collinsella sp.An7、Collinsella sp.An2、Collinsella ihuae、Collinsella
stercoris、Collinsella sp.An268、Collinsella sp.An307、Collinsella phocaeensis、
The combination of one or more of Collinsella intestinalis, Collinsella vaginalis.
The purposes in enteric microorganism is being adjusted according to the composition comprising charred RADIX ET RHIZOMA RHEI, can be selective suppression
The quantity of bacterium in enteron aisle processed, the bacterium are selected from: enterococcus spp (Enterococcus), false Butyrivibrio
(Pseudobutyrivibrio), streptomyces (Streptomyces), bacillus genus (Paenibacillus), aquatic
Pseudomonas (Enhydrobacter), Caulobacter (Caulobacter), shigella (Shigella), Rhizobiales order
(Rhizobiales), Achromatium (Achromobacter), Methylobacter (Methylobacterium), lactococcus
(Lactococcus), anaerobism Ureaplasma (Anaeroplasma), streptococcus (Streptococcus), secondary bar shape Pseudomonas
(Parabacteroides), Butyrivibrio (Butyrivibrio), Megasphaera (Megasphaera), Brachyspira
(Brachyspira), salt water Coccus (Salinicoccus), Acidaminococcus (Acidaminococcus), succinic acid arc
Pseudomonas (Succinivibrio), Rothia (Roseburia), zygosaccharomyces (Ferrimonas), koala Bacillus
One or more of (Phascolarctobacterium) combination；
Preferably, the bacterium is selected from: enterococcus spp, shigella, Achromatium, Methylobacter, secondary bar shape
The combination of one or more of Pseudomonas；
It is furthermore preferred that the bacterium is selected from: Enterococcus sp.HMSC034B11, Enterococcus
sp.HMSC063H10、Enterococcus sp.HMSC074F07、Pseudobutyrivibrio sp.AR14、
Streptomyces sp.b94、Paenibacillus sp.J6、Enterobacter sp.BIDMC87、Enhydrobacter
sp.H5、Caulobacter sp.CCH4-E1、Shigella sonnei、Shigella sp.PAMC 28760、
Rhizobiales bacterium CCH9-A3、Achromobacter sp.ATCC35328、Methylobacterium
sp.UNCCL110、Lactococcus raffinolactis、Streptococcus sp.AS20、Streptococcus
sp.DD10、Streptococcus sp.CCH8-G7、Streptococcus sp.2_1_36FAA、Streptococcus
sp.HMSC077F03、Streptococcus sp.HMSC10A01、Streptococcus sp.HMSC034E12、
Streptococcus sp.HMSC064H09、Streptococcus sp.HMSC064H02、Streptococcus sp.CM7、
Streptococcus sp.HMSC078E08、Parabacteroides sp.D25、Megasphaera sp.BV3C16-1、
Brachyspira pilosicoli、Salinicoccus carnicancri、Acidaminococcus intestini、
Acidaminococcus sp.D21、Succinivibrio dextrinosolvens、Roseburia faecis、
One or more of Ferrimonas kyonanensis, Phascolarctobacterium succinatutens
Combination.
The purposes in enteric microorganism is being adjusted according to the composition comprising charred RADIX ET RHIZOMA RHEI, can be selective suppression
Viral quantity in enteron aisle processed, the virus are selected from: streptococcus virus (Streptococcus virus), enterococcus bacteriophage
(Enterococcus phage), Bacillus acidi lactici bacteriophage (Lactobacillus phage), enterobacteria bacteriophage
The combination of one or more of (Enterobacteria phage)；
Preferably, the virus is selected from: streptococcus virus；
It is furthermore preferred that the virus is selected from: Streptococcus virus 7201, Streptococcus virus
The combination of one or more of DT1, Streptococcus virus Sfi19.
The purposes in enteric microorganism is being adjusted according to the composition comprising charred RADIX ET RHIZOMA RHEI, can be selective suppression
The quantity of fungi in enteron aisle processed, the fungi are aspergillus flavus (Aspergillus flavus).
Composition of the present invention comprising charred RADIX ET RHIZOMA RHEI is charred RADIX ET RHIZOMA RHEI and is selected from Qi-tonifying drug, antianaemics, yin tonics, Wen Hua
The combination of one or more of cold phlegm medicine, blood-cooling hemostatic, inducing diuresis for removing edema or heat-clearing drug.
The Qi-tonifying drug is selected from: ginseng, American Ginseng, Radix Codonopsis, radix pseudostellariae, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Chinese yam, Semen Lablab Album, Radix Glycyrrhizae, big
The combination of one or more of jujube, wilsonii, gynostemma pentaphylla, root of kirilow rhodiola, sea-buckthorn, maltose, honey；Preferably, the benefit
Gas medicine is selected from: the combination of one or more of Radix Astragali, ginseng, Chinese yam, root of kirilow rhodiola.
The antianaemics is selected from: one of Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Paeoniae Alba, donkey-hide gelatin, the fleece-flower root, arillus longan, Paper mulberry Fruit or two
Kind or more combination；Preferably, the antianaemics is selected from: one or both of Radix Angelicae Sinensis, Rehmannia glutinosa.
The yin tonics is selected from: Radix Glehniae, adenophora tetraphylla, lily, Radix Ophiopogonis, asparagus fern, dendrobium nobile, radix polygonati officinalis, rhizoma polygonati, Radix changii, Chinese holly
One or more of matrimony vine, eclipta, the fruit of glossy privet, mulberry fruit, Semen sesami nigrum, tortoise plastron, turtle shell, tremella, bird's nest, fish glue
Combination；Preferably, the yin tonics is selected from: the group of one or more of Radix Glehniae, lily, Radix Ophiopogonis, dendrobium nobile, rhizoma polygonati
It closes.
The medicine for warming and resolving cold-phlegm is selected from: the tuber of pinellia, rhizoma arisaematis, semen brassicae, Chinese honey locust, Inula britannica chinensis, bulbus fritillariae cirrhosae, Snakegourd Fruit, caulis bambusae in taenian, bamboo
The combination of one or more of drip, tabasheer, the root of purple-flowered peucedanum, campanulaceae, the sterculia seed；Preferably, the medicine for warming and resolving cold-phlegm is selected from:
The tuber of pinellia, rhizoma arisaematis, the combination of one or more of campanulaceae.
The blood-cooling hemostatic is selected from: Radix Notoginseng, field thistle, setose thistle, garden burnet, sophora flower, cacumen biotae, rhizoma imperatae, Radix Curcumae, radix boehmeriae
One or more of combination；Preferably, the blood-cooling hemostatic is selected from: Radix Notoginseng, rhizoma imperatae, Radix Curcumae, in garden burnet
A combination of one or more；It is furthermore preferred that the blood-cooling hemostatic is selected from: Radix Notoginseng, rhizoma imperatae, Radix Curcumae.
The edema-alleviating diuretic is selected from: Poria cocos, adlay, umbellate pore furgus, rhizoma alismatis, waxgourd peel, corn stigma, cucurbit, cortex periplocae, trifoliate orange Dulcis
The combination of one or more of son, wartwort, mole cricket, shepherd's purse；Preferably, the edema-alleviating diuretic is selected from: Poria cocos, the heart of a lotus seed
The combination of one or more of benevolence, corn stigma；It is furthermore preferred that the edema-alleviating diuretic is selected from: adlay.
The heat-clearing drug is selected from: one of radix rehmanniae recen, radix scrophulariae, cortex moutan, radix paeoniae rubra, Asian puccoon, cornu bubali, rabdosia lophanthide
Or two or more combination；Preferably, the heat-clearing drug is selected from: one or both of radix rehmanniae recen, radix scrophulariae.
Composition of the present invention comprising charred RADIX ET RHIZOMA RHEI, charred RADIX ET RHIZOMA RHEI be selected from Qi-tonifying drug, antianaemics, yin tonics, Wen Hua
The combined portion rate of one or more of cold phlegm medicine, blood-cooling hemostatic, inducing diuresis for removing edema or heat-clearing drug is 1-99:
99-1。
In a preferred embodiment of this invention, the composition comprising charred RADIX ET RHIZOMA RHEI be charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Notoginseng,
The combination of charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Curcumae.
In a preferred embodiment of this invention, part of charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Notoginseng, charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Curcumae
Number is than being 1:1:1,2:1:1,5:1:1.
It preferably, further include acceptable auxiliary material in pharmacy in the composition comprising charred RADIX ET RHIZOMA RHEI, the auxiliary material choosing
From: carrier, diluent, adhesive, lubricant, wetting agent.
Preferably, the dosage form of the composition comprising charred RADIX ET RHIZOMA RHEI is selected from: tablet, capsule, pill, injection, inhalant,
Lozenge, emulsion, microemulsion, sub-micellar emulsion, nano particle, gelling agent, pulvis, suspended emulsion, cream, jelly, is sprayed suppository
Agent etc..
Preferably, the administration mode that the composition comprising charred RADIX ET RHIZOMA RHEI can be taken is selected from: oral, intestinal canal administration, subcutaneous
Injection, intramuscular injection, intravenous injection, nasal-cavity administration, cutaneous penetration, sub-conjunctival administration, administration, eye socket administration, eyeball in eyeball
Administration, retina administration, choroid administration, intrathecal injection etc. afterwards.
The present invention provides a kind of application of the composition comprising charred RADIX ET RHIZOMA RHEI in medicine preparation, and the drug is treatment and intestines
The drug of road Flora Disturbance related disease, it is preferred that the disease is selected from: long-term diarrhea, constipation, obesity, food hypersenstivity, pancreas
It includes pregnant that adenositis, hepatic injury, intestinal inflammatory, which include Crohn disease, irritable bowel syndrome, digestive tract ulcer, kidney stone, diabetes,
Phase diabetes, rheumatoid arthritis, Behcet's disease, cardiovascular disease, the cranial vascular disease of being pregnent include apoplexy, tumour, paralysis, eye
Disease, multiple sclerosis, ankylosing spondylitis, parkinsonism, anxiety, self-closing disease, depression, chronic fatigue syndrome.
Charred RADIX ET RHIZOMA RHEI of the present invention is rheum officinale powdered carbon or charred RADIX ET RHIZOMA RHEI extract, it is preferred that the charred RADIX ET RHIZOMA RHEI is charred RADIX ET RHIZOMA RHEI
Extract.
A kind of preparation method of rheum officinale powdered carbon the following steps are included: (1) rheum officinale clean removal of impurities, (2) stripping and slicing, (3) frying,
(4) it crushes, (5) packaging.
Preferably, frying in the step (3) to rheum officinale outer surface is in black.
Preferably, charred RADIX ET RHIZOMA RHEI is crushed to 200-1200 mesh in the step (4)；It is furthermore preferred that big in the step (4)
Yellow charcoal is crushed to 800-1200 mesh.
Preferably, it is vacuum-packed after rheum officinale powdered carbon being carried out sterilization treatment in the step (5).
Charred RADIX ET RHIZOMA RHEI extract extracting method is selected from: solvent extraction method, percolation, decocting method, circumfluence method, continuous backflow method,
Ultrasonic extraction, supercritical fluid extraction, steam distillation, sublimed method, resin adsorption partition method, gel chromatography separation
Method；
Preferably, the extracting method is selected from: solvent extraction method, decocting method, resin adsorption partition method.
A kind of preparation method of charred RADIX ET RHIZOMA RHEI extract the following steps are included:
(1) by charred RADIX ET RHIZOMA RHEI raw material stoving, charred RADIX ET RHIZOMA RHEI coarse powder is crushed to obtain；
(2) charred RADIX ET RHIZOMA RHEI coarse powder solvent extraction carries out that charred RADIX ET RHIZOMA RHEI concentrate is concentrated under reduced pressure to obtain after filtering；
(3) charred RADIX ET RHIZOMA RHEI concentrate is crossed adsorption column to elute, first with purifying water washing, removes impurity, use ethanol elution
Obtain eluent；
(4) eluent, decolorization is concentrated under reduced pressure, purification is concentrated under reduced pressure into medicinal extract, obtains charred RADIX ET RHIZOMA RHEI extract after dry.
Preferably, solvent is selected from the step (2): n,N-Dimethylformamide, acetic acid, methylene chloride, methanol, second
Alcohol, isopropanol, the tert-butyl alcohol, acetonitrile or acetone；It is furthermore preferred that the solvent is selected from: 50%-80% ethanol solution.
Preferably, absorption column packing is selected from the step (3): HPD series, ADS series, HZ series, XAD series and D
One of serial macroreticular resin filler or more than one combination；It is furthermore preferred that the absorption column packing is selected from: HPD100,
One of HZ18 and D101 or more than one combination.
Preferably, drying mode is selected from the step (4): spray drying, vacuum drying, freeze-drying, near-infrared are dry
One of dry and microwave drying or more than one combination；It is more preferably dried in vacuo, drying temperature is 30-50 DEG C.
Detailed description of the invention
The enteric microorganism species that Fig. 1 charred RADIX ET RHIZOMA RHEI changes
The enteric microorganism species that Fig. 2 charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and notoginseng composition change
The enteric microorganism species of Fig. 3 charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Curcumae composition change
Specific embodiment
The preparation of 1 rheum officinale powdered carbon of embodiment
Raw rhubarb is cleaned, stripping and slicing, is dried, is heated with high heat, frying to outer surface is in black, with i.e. by the charred RADIX ET RHIZOMA RHEI of frying
It is crushed in input pulverizer in time while hot, is crushed to 900 mesh, after the rheum officinale powdered carbon for being ground into powder is carried out sterilization treatment
Vacuum packaging.
2 ethanol immersion of embodiment prepares charred RADIX ET RHIZOMA RHEI extract
The charred RADIX ET RHIZOMA RHEI bulk pharmaceutical chemicals of drying are crushed to 20 mesh and obtain charred RADIX ET RHIZOMA RHEI coarse powder, charred RADIX ET RHIZOMA RHEI coarse powder is mentioned with 80% ethanol solution
It takes 3 times, after extracting solution filtering carries out that charred RADIX ET RHIZOMA RHEI concentrate is concentrated under reduced pressure to obtain, charred RADIX ET RHIZOMA RHEI concentrate is crossed into adsorption column and is eluted,
Absorption column packing is HPD100, first with purifying water washing, removes impurity, then must be eluted with 60%, 70%, 80% ethanol elution
Liquid, is concentrated under reduced pressure eluent, decolorization, and purification is concentrated under reduced pressure into medicinal extract, obtains charred RADIX ET RHIZOMA RHEI extract after freeze-dried.
3 water boiling method of embodiment prepares charred RADIX ET RHIZOMA RHEI extract
100g charred RADIX ET RHIZOMA RHEI is weighed, is set in the pan-fried device of suitable volume, adds water about 600ml to submerge medicinal material 1h, is heated after boiling
0.5h.Fried liquid is separated, the dregs of a decoction carry out secondary decoction, and fried liquid is mixed with fried liquid for the first time, volume are measured with graduated cylinder, if body
Fried liquid is then further boiled more than 600ml and is concentrated into about 600ml by product, is reached fried liquid progress vacuum packet after respective volume
Dress, is filled in 7-8 pouch, is put into 4 DEG C and saves for use.
The preparation of embodiment 4 charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and notoginseng composition
Charred RADIX ET RHIZOMA RHEI extract, cogongrass rhizome extractive and Notogineng Extract are respectively adopted solvent extraction method and extract, resin
Adsorption separation method is separated, and is obtained after freeze-drying, and charred RADIX ET RHIZOMA RHEI extract, cogongrass rhizome extractive and Notogineng Extract are respectively taken
1 part is sufficiently mixed, and the composition of charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Notoginseng is made.
The preparation of embodiment 5 charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Curcumae composition
Charred RADIX ET RHIZOMA RHEI extract, cogongrass rhizome extractive and Radix Curcumae extract are respectively adopted solvent extraction method and extract, resin
Adsorption separation method is separated, and is obtained after freeze-drying, and charred RADIX ET RHIZOMA RHEI extract, cogongrass rhizome extractive and Radix Curcumae extract are respectively taken
1 part is sufficiently mixed, and the composition of charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Curcumae is made.
6 charred RADIX ET RHIZOMA RHEI of embodiment and influence of the composition to enteric microorganism comprising charred RADIX ET RHIZOMA RHEI
This experiment uses monkey as experimental subjects to test, and experimental drug is respectively the charred RADIX ET RHIZOMA RHEI prepared according to embodiment 3-5
The composition of extract, charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and the composition of Radix Notoginseng, charred RADIX ET RHIZOMA RHEI and rhizoma imperatae and Radix Curcumae, administration mode are warp
Nose gastric infusion, stomach-filling are continuous 14 days once a day.Each 1 day excrement before and after daily, stomach-filling in acquisition stomach-filling 14 days.It is real
Standard inspection is quasi- as follows: monkey raising is executed according to non-human primate experimental animal feeding standard, and 8 points of every morning carries out cage for animal bottom
Rinse, a stainless (steel) wire be put into cage for animal bottom, wait monkey voluntarily defecation later, check monkey ID after defecation, to excrement into
Row is taken pictures, and is acquired excrement using urine collector, is paid attention to the excrement for avoiding contacting with wire side in collection process, be put into -80 DEG C of ice later
Case saves.
The extraction of DNA is extracted using strength faeces DNA extracts kit (Qiagen, USA), each sample extraction
100ng DNA is crushed the DNA fragmentation that 300-400bp is made in instrument with non-contact type ultrasonic, uses high-flux sequence platform library
Building orientation optimization kit VAHTS Nano DNA Library Prep Kit for Illumina (Vazyme, China) into
Row sequencing, sequencing depth is up to 3,000 ten thousand -5 thousand ten thousand each samples, to each sequencing reading progress quality control, for non-source of people sequence
Column are analyzed using Kraken and Bracken, and using customized database as reference, this database is included in 2017 12
Bacterium, archeobacteria, virus, fungi and protozoic genome all in RefSeq before the moon 22.
Experimental result as shown in table 1-3, finds after counting to experimental result, charred RADIX ET RHIZOMA RHEI extract and includes charred RADIX ET RHIZOMA RHEI
Influence of the composition to enteric microorganism include selectivity the quantity for increasing some bacteriums in enteron aisle, while inhibiting in enteron aisle
The quantity of other bacterium and inhibit in enteron aisle some viruses, fungies to play a role.
The enteric microorganism species that 1 charred RADIX ET RHIZOMA RHEI of table changes
The enteric microorganism species that 2 charred RADIX ET RHIZOMA RHEI of table and rhizoma imperatae and notoginseng composition change
The enteric microorganism species of 3 charred RADIX ET RHIZOMA RHEI of table and rhizoma imperatae and Radix Curcumae composition change
Claims (16)
1. charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism.
2. charred RADIX ET RHIZOMA RHEI according to claim 1 is adjusting the purposes in enteric microorganism, which is characterized in that the adjusting
Enteric microorganism is the quantity for increasing bacterium in enteron aisle of selectivity, and the bacterium is selected from: lactobacillus
(Lactobacillus), pseudomonas (Pseudomonas), streptomyces (Streptomyces), mycobacterium
(Mycobacterium), acinetobacter (Acinetobacter), lactococcus (Lactococcus), Helicobacterium
(Helicobacter), Brevibacillus (Brevibacillus), staphylococcus (Staphylococcus), extra large bacillus
Belong to (Marinobacter), Treponema (Treponema), enlightening thatch Pseudomonas (Dietzia), Bacteroides
(Bacteroides), Burkholderia (Burkholderia), Rhod (Rhodococcus), fusobacterium
(Clostridium), the group of one or more of paracoccus (Paracoccus), dark Bacillus (Pelobacter)
It closes.
3. charred RADIX ET RHIZOMA RHEI according to claim 2 is adjusting the purposes in enteric microorganism, which is characterized in that the bacterium choosing
From: one or both of lactobacillus, pseudomonas, acinetobacter, Helicobacterium, Treponema, fusobacterium with
On combination.
4. charred RADIX ET RHIZOMA RHEI according to claim 1 is adjusting the purposes in enteric microorganism, which is characterized in that the adjusting
Enteric microorganism is the quantity for inhibiting bacterium in enteron aisle of selectivity, and the bacterium is selected from: secondary bar shape Pseudomonas
(Parabacteroides), bacillus genus (Paenibacillus), campylobacter (Campylobacter), intestines bar
Pseudomonas (Enterobacter), Ruminococcus (Ruminococcus), Cellulomonas (Fibrobacter), streptococcus
(Streptococcus), Nostoc (Nostoc), Selenomonas (Selenomonas), Anaerovibrio
(Anaerovibrio), hemophilus (Haemophilus), Brachyspira (Brachyspira), enterococcus spp
(Enterococcus), Escherichia (Escherichia), raw rhizobium (Mesorhizobium), bacillus
(Bacillus), the combination of one or more of bud zygosaccharomyces (Blastomonas).
5. charred RADIX ET RHIZOMA RHEI according to claim 4 is adjusting the purposes in enteric microorganism, which is characterized in that the bacterium choosing
From: one of secondary bar shape Pseudomonas, bacillus genus, campylobacter, Cellulomonas, streptococcus, enterococcus spp or
Two or more combinations.
6. charred RADIX ET RHIZOMA RHEI according to claim 1 is adjusting the purposes in enteric microorganism, which is characterized in that the adjusting
Enteric microorganism is the quantity for inhibiting fungi in enteron aisle of selectivity, and the fungi is selected from: aspergillus flavus (Aspergillus
flavus)。
7. the application of charred RADIX ET RHIZOMA RHEI in medicine preparation, the drug is the drug for the treatment of with enteric flora disturbance related disease.
8. the application of charred RADIX ET RHIZOMA RHEI according to claim 7 in medicine preparation, which is characterized in that the disease is selected from: long
Phase diarrhea, constipation, obesity, food hypersenstivity, pancreatitis, hepatic injury, intestinal inflammatory, irritable bowel syndrome, digestive tract ulcer, kidney knot
It is stone, diabetes, rheumatoid arthritis, Behcet's disease, cardiovascular disease, cranial vascular disease, tumour, paralysis, eye disease, multiple hard
Change disease, ankylosing spondylitis, parkinsonism, anxiety, self-closing disease, depression, chronic fatigue syndrome；Preferably, the intestinal inflammatory
Selected from Crohn disease, the diabetes are selected from gestational diabetes.
9. the composition comprising charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism.
10. purposes of the composition according to claim 9 comprising charred RADIX ET RHIZOMA RHEI in adjusting enteric microorganism, feature exist
In the composition comprising charred RADIX ET RHIZOMA RHEI is charred RADIX ET RHIZOMA RHEI and is selected from Qi-tonifying drug, antianaemics, yin tonics, medicine for warming and resolving cold-phlegm, cool blood
The combination of one or more of hemostatic, edema-alleviating diuretic or heat-clearing drug.
11. the composition according to claim 10 comprising charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism, feature
Be, the Qi-tonifying drug is selected from: ginseng, American Ginseng, Radix Codonopsis, radix pseudostellariae, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Chinese yam, Semen Lablab Album, Radix Glycyrrhizae, jujube,
The combination of one or more of wilsonii, gynostemma pentaphylla, root of kirilow rhodiola, sea-buckthorn, maltose, honey；The antianaemics is selected from: when
Return, the combination of Rehmannia glutinosa, Radix Paeoniae Alba, donkey-hide gelatin, the fleece-flower root, arillus longan, one or more of Paper mulberry Fruit；The yin tonics choosing
From: Radix Glehniae, adenophora tetraphylla, lily, Radix Ophiopogonis, asparagus fern, dendrobium nobile, radix polygonati officinalis, rhizoma polygonati, Radix changii, fructus lycii, eclipta, the fruit of glossy privet, mulberry
The combination of one or more of mulberry, Semen sesami nigrum, tortoise plastron, turtle shell, tremella, bird's nest, fish glue；The medicine for warming and resolving cold-phlegm choosing
From: the tuber of pinellia, rhizoma arisaematis, semen brassicae, Chinese honey locust, Inula britannica chinensis, bulbus fritillariae cirrhosae, Snakegourd Fruit, caulis bambusae in taenian, bamboo juice, tabasheer, the root of purple-flowered peucedanum, campanulaceae, fat big
Marine a combination of one or more；The blood-cooling hemostatic is selected from: Radix Notoginseng, field thistle, setose thistle, garden burnet, sophora flower, arbor-vitae
The combination of one or more of leaf, rhizoma imperatae, Radix Curcumae, radix boehmeriae；The edema-alleviating diuretic is selected from: Poria cocos, adlay, pig
The group of one or more of Siberian cocklebur, rhizoma alismatis, waxgourd peel, corn stigma, cucurbit, cortex periplocae, hoveniae semoveniae semen, wartwort, mole cricket, shepherd's purse
It closes；The heat-clearing drug is selected from: one of radix rehmanniae recen, radix scrophulariae, cortex moutan, radix paeoniae rubra, Asian puccoon, cornu bubali, rabdosia lophanthide or two
Kind or more combination.
12. the composition according to claim 11 comprising charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism, feature
It is, the blood-cooling hemostatic is rhizoma imperatae, Radix Notoginseng, Radix Curcumae.
13. the application of the composition comprising charred RADIX ET RHIZOMA RHEI in medicine preparation, the drug is that treatment is related to enteric flora disturbance
The drug of disease.
14. charred RADIX ET RHIZOMA RHEI according to claim 1 is in the purposes adjusted in enteric microorganism or as claimed in claim 9 includes
The composition of charred RADIX ET RHIZOMA RHEI is adjusting the purposes in enteric microorganism, which is characterized in that the charred RADIX ET RHIZOMA RHEI is for rheum officinale powdered carbon or greatly
Yellow charcoal extract.
15. charred RADIX ET RHIZOMA RHEI according to claim 14 or the composition comprising charred RADIX ET RHIZOMA RHEI are adjusting the use in enteric microorganism
On the way, which is characterized in that the rheum officinale powdered carbon is that charred RADIX ET RHIZOMA RHEI is crushed to 200-1200 mesh.
16. charred RADIX ET RHIZOMA RHEI according to claim 14 or the composition comprising charred RADIX ET RHIZOMA RHEI are adjusting the use in enteric microorganism
On the way, which is characterized in that the extracting method of the charred RADIX ET RHIZOMA RHEI extract is selected from: solvent extraction method, percolation, decocting method, circumfluence method,
Continuous backflow method, ultrasonic extraction, supercritical fluid extraction, steam distillation, sublimed method, resin adsorption partition method or solidifying
Glue chromatography.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115369059A (en) * | 2022-08-22 | 2022-11-22 | 四川农业大学 | Lactococcus with resistance to infection of aquatic animal aeromonas hydrophila and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251913A (en) * | 2013-05-30 | 2013-08-21 | 潍坊诺达药业有限公司 | Traditional Chinese medicine composition for protecting gastrointestinal tract of livestock and preparation method thereof |
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2018
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| CN103251913A (en) * | 2013-05-30 | 2013-08-21 | 潍坊诺达药业有限公司 | Traditional Chinese medicine composition for protecting gastrointestinal tract of livestock and preparation method thereof |
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| 史艳莉等: "大黄炭的抗腹泻作用", 《中国医院药学杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115369059A (en) * | 2022-08-22 | 2022-11-22 | 四川农业大学 | Lactococcus with resistance to infection of aquatic animal aeromonas hydrophila and application thereof |
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Application publication date: 20191203 |