CN110522415A - A kind of ANIMAL PAIN test macro and its test method - Google Patents
A kind of ANIMAL PAIN test macro and its test method Download PDFInfo
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- CN110522415A CN110522415A CN201910763834.0A CN201910763834A CN110522415A CN 110522415 A CN110522415 A CN 110522415A CN 201910763834 A CN201910763834 A CN 201910763834A CN 110522415 A CN110522415 A CN 110522415A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4824—Touch or pain perception evaluation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
Abstract
The invention discloses a kind of ANIMAL PAIN test macros, comprising: animal activity device, including the limited area for animal activity, the limited area is provided with multiple stimulation needles of array distribution；Video acquisition device, for obtaining video information of animal when by the limited area；Data processing equipment, for handling the video information, analysis obtains the activity trajectory information of animal, and obtains the pain level of specific position of the animal in the limited area to the activity trajectory information analysis according to preset analysis rule.The present invention also correspondence discloses a kind of ANIMAL PAIN test method.Technical solution in through the invention, the pain sensation that needle effectively can be stimulated to animal is stimulated is tested and is quantified, and provides research information abundant for the pain research of animal, is conducive to the accuracy and sensitivity that increase experiment, experimental error is reduced, and guarantees the objectivity of pain test result.
Description
Technical field
The invention belongs to pain sensation studying technological domain, a kind of ANIMAL PAIN test macro and its test method are related generally to.
Background technique
Pain is a kind of common clinical symptoms, and pain is brought in life many inconvenient negative with psychology to the life of people
It influences.At present clinically to the mainly description according to patient to the subjective feeling of pain of pain diagnostic method, there is no one now
Kind it is capable of the Scientific evaluation mode of accurate quantification pain value, there is huge differences for the accuracy of pain Assessment.
Effectively assessment and correct identification is Scientific evaluation pain prerequisite, it is necessary first to establish Pain Detection Threshold, most
The standard of weak pain intensity, can allow each subject's independent reaction pain, complete reliable, accurate subjective pain evaluation quantity
Table.However, the subjective scale of self-assessment still has big intrinsic scarce of poor sensibility, single behavior sign and observer's difference
Point is unable to satisfy the effective assessment and correct identification being badly in need of in reality diagnosis.
When carrying out pain research, generally made a search object using animal, but the pain Assessment of animal is more difficult, currently
There are the measurement of several subjectivities and assessment mode to be used to evaluate ANIMAL PAIN, and plays leading work in ANIMAL PAIN evaluation studies
With.ANIMAL PAIN appraisal procedure can be used: threshold value feels quantitative test (QST) method, gait point after the operation of mechanical and thermalgesia
Analysis method and animal production capacity index evaluating method.However, ANIMAL PAIN is caused by number of mechanisms, the corresponding expression behaviour of animal compared with
For complexity, evade or hide certain behaviors sometimes, while the behavior of animal can also change with kind, damage and environmental change
Become.It can not be linked up in the detection process with human language and animal, can not also become ANIMAL PAIN assessment even across verifying
Standard, it is difficult to realize accurate quantification ANIMAL PAIN purpose, it is also difficult to guarantee the objectivity of experiment.
Summary of the invention
Present invention aims at the defects for being directed to existing method, provide a kind of ANIMAL PAIN test macro and its test side
Method, the pain sensation that effectively can be stimulated needle to animal is stimulated are tested and are quantified, for animal pain research provide it is abundant
Research information, be conducive to the accuracy and sensitivity that increase experiment, reduce experimental error, and guarantee pain test result
Objectivity.
In order to solve the above technical problems, the present invention is implemented by following scheme:
A kind of ANIMAL PAIN test macro, comprising:
Animal activity device, including the limited area for animal activity, the limited area is provided with the more of array distribution
A stimulation needle；
Video acquisition device, for obtaining video information of animal when by the limited area；
Data processing equipment, for handling the video information, analysis obtains the activity trajectory information of animal, and according to pre-
If analysis rule the pain level of specific position of the animal in the limited area is obtained to the activity trajectory information analysis.
Compared with prior art, the vantageous methods effect of this system is as follows:
A kind of ANIMAL PAIN test macro disclosed by the invention, by the video information to animal through stimulation oversaturation needle region into
Row obtains, then is analyzed by the activity trajectory information of animal the pain level of animal, can effectively be stimulated to animal
The pain sensation that needle is stimulated is tested and is quantified, and provides research information abundant for the pain research of animal, is conducive to increase real
The accuracy and sensitivity tested reduce experimental error, and guarantee the objectivity of pain test result.
This system further improvement lies in that, the animal activity device include a test cabinet；The inside of the test cabinet
Space is divided into behaviour area, and the area pellucida and dark space of the behaviour area two sides is arranged in；
The area pellucida is provided with lighting module so that the brightness in the area pellucida is higher than the first preset threshold；
The dark space, which is provided with, blocks module so that the brightness of the dark space is lower than the second preset threshold；
The ground of the behaviour area is provided with multiple stimulation needles of the array distribution.
This system further improvement lies in that, the needle point of multiple stimulation needles of the array distribution of behaviour area setting
Area proportionally increases or reduces from the side close to the area pellucida to the side close to the dark space.
This system further improvement lies in that, the data processing equipment includes:
Image processing module handles the video information using image processing algorithm, obtains the image matter of animal
The heart；
Trajectory analysis module counts the motion track of the image mass center of the animal in preset time, obtains
Activity trajectory information of the animal in the limited area；
Pain level analysis module obtains animal in institute to the activity trajectory information analysis according to preset analysis rule
State the pain level of the specific position of limited area.
This system further improvement lies in that, described image Processing Algorithm includes:
Obtain the image of animal in the video information；
To carrying out contours extract after the Yunnan snub-nosed monkey of the animal；
The mass center of the image is obtained by edge calculations.
This system further improvement lies in that, the analysis rule includes:
Calculate the speed that animal in the activity trajectory information passes through a setting position；
Animal is converted in the pain level of the setting position by the speed using preset speed-pain sensation relationship；
In the speed-pain sensation relationship, speed is directly proportional to pain level；
And/or
Calculate the frequency that animal in the activity trajectory information appears in a setting position；
Pain level using preset frequency-pain sensation relationship by the frequency translation for animal in the setting position；
In the frequency-pain sensation relationship, frequency is inversely proportional with pain level.
This system further improvement lies in that, further includes:
Vital sign information collection device, for collecting vital sign information of animal when by the limited area；
The vital sign information includes the body temperature information and blood pressure information, respiration information of animal.
This system further improvement lies in that, further includes:
Environmental information collection device, for obtaining environmental information of animal when by the limited area；The environment
Information includes ambient temperature information and environmental voice information.
This system further improvement lies in that, the data processing equipment include a database module；
The database module, for collecting the pain level, vital sign information and environmental information, to establish animal
Pain behaviour database.
Also correspondence discloses a kind of ANIMAL PAIN test method in the present invention, carries out by above-mentioned ANIMAL PAIN test macro
Implement, comprising the following steps:
Animal is placed on carry out activity in the limited area of animal activity device；The limited area is provided with array point
Multiple stimulation needles of cloth；
Video information of animal when by the limited area is obtained using video acquisition device；
The video information is handled using data processing equipment, analysis obtains the activity trajectory information of animal, and according to pre-
If analysis rule the pain level of specific position of the animal in the limited area is obtained to the activity trajectory information analysis.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of ANIMAL PAIN test macro described in the embodiment of the present invention 1；
Fig. 2 is the structural schematic diagram that needle array is stimulated described in the embodiment of the present invention 1；
Fig. 3 is the schematic diagram of hotspot's distribution figure described in the embodiment of the present invention 1；
Fig. 4 is the step schematic diagram of ANIMAL PAIN test method described in the embodiment of the present invention 2.
In figure:
1- test cabinet；10- active clapboard；The behaviour area 11-；111- stimulates needle；The area pellucida 12-；The dark space 13-；2- camera.
Specific embodiment
In order to be fully understood from the purpose of the present invention, feature and effect, below with reference to attached drawing and specific embodiment pair
The method effect of design of the invention, specific steps and generation is described further.
Embodiment 1
As shown in Figure 1, present embodiment discloses a kind of ANIMAL PAIN test macro, including test cabinet 1 and camera 2；Its
Middle camera 2 is used to obtain video information of the animal in test cabinet 2 when activity；Specifically, the top opening of test cabinet 1, with
Just animal, such as mouse are put into test cabinet 1 by operator；Specifically, the shell of test cabinet 1 is transparent, organic glass or height are used
The preparation of molecule material.
Specifically, the inner space of test cabinet 1 is divided into behaviour area 11, and the area pellucida 12 of behaviour area two sides is set
With dark space 13, wherein between area pellucida 12 and behaviour area 11 and between dark space 13 and behaviour area 11, by active clapboard 10 into
Row separates, and active clapboard 10 is prepared using organic glass or macromolecule material, can move up and down along the inner wall of test cabinet 1, with
Animal is limited in the zone of action of test cabinet 1.
Specifically, area pellucida 12 is provided with lighting module, specifically it can be kept by the illuminating device in white light source etc
Brightness is higher than preset luminance threshold；Specifically, dark space 13 is provided with and blocks module, specifically, can be by using isolation light source
Cloth blocked so that the brightness of dark space be lower than preset luminance threshold；
Specifically, the ground of behaviour area 11 is provided with multiple stimulation needles 111 of array distribution, specifically, stimulation needle 111
The top view and side view of distribution are as shown in Figure 2.
Specifically in the present embodiment, every root thorn swash needle 111 needle point area from 12 side of area pellucida to 13 side of dark space by
Gradually successively decrease, to increase pressure；Specifically, the height of stimulation needle is 0.6cm, stimulating the base diameter of needle is 0.4mm, stimulates needle
Tip diameter is gradually incremented to 2mm from 0.2mm, specifically, the spacing of every needle is 1.6mm in array, collectively constitutes one wide
The needle-shaped array of about 61mm, a length of 400mm can also increase the quantity of the needle of different size needle point, in proportion to increase array
Length.
In specific the present embodiment, stimulation needle 111 selects resin material, is prepared using 3D increasing material manufacturing mode.
Specifically, by the setting in above-mentioned area pellucida and dark space, when actual test, animal need to be only placed on survey by operator
It tries in cabinet, and induces the animal such as mouse of photophobia, it is mobile from bright areas toward dark area, maintain animal subject activity direction
Consistency, to improve the accuracy of pain Assessment.
Specifically, camera 2 is in animal, such as mouse, by behaviour area 11 ground when, the video information of animal is carried out
It obtains；Specific camera 2 is connected to a data processing equipment, and data processing equipment handles the video information that camera 2 obtains,
Analysis obtains the activity trajectory information of animal, and obtains animal to activity trajectory information analysis according to preset analysis rule and limiting
Determine the pain level of the specific position in region.Specifically, data processing equipment can be to be provided with the processor for executing code；Tool
In the present embodiment, camera 2 selects CCD high-definition camera, the mountable top in test cabinet of CCD camera, lower section to body
Or arranged on left and right sides, as long as can adjust camera lens can take clearly mouse activity trajectory.CCD camera shooting is adopted
Collection image resolution ratio is at least 606*345 pixel, and frame per second is at least 15 frames/second.
Specifically, data processing equipment includes:
Image processing module is handled video information using image processing algorithm, obtains the image mass center of animal；Tool
Body, image processing algorithm includes:
Obtain the image of animal in video information；
To carrying out contours extract after the Yunnan snub-nosed monkey of animal；
The mass center of image is obtained by edge calculations.
Trajectory analysis module counts the motion track of the image mass center of the animal in preset time, obtains animal
In the activity trajectory information of limited area；
Specifically in the present embodiment, first collected video image is first carried out gray processing, image gray-scale transformation or in
The pretreatment such as value filtering, and then binaryzation, morphologic filtering or object edge contours extract are carried out to image, finally use edge
The mass center of target namely animal image is calculated in detection, is tracked using center of mass point to detection target, finally output detection
Object motion profile is shown on hotspot's distribution figure as shown in Figure 3.
Specifically, in the hotspot's distribution figure of Fig. 3, abscissa and ordinate respectively represent the ground region of behaviour area 11
Two orthogonal sides, hotspot's distribution figure intuitively reflect animal in the activity trajectory of behaviour area 11.
Pain level analysis module obtains animal to activity trajectory information analysis according to preset analysis rule and is limiting area
The pain level of the specific position in domain.Specifically, analysis rule includes:
Calculate the speed that animal in activity trajectory information passes through a setting position；
Animal is converted in the pain level of setting position by speed using preset speed-pain sensation relationship；Speed-the pain sensation
In relationship, speed is directly proportional to pain level；
And/or
Calculate the frequency that animal in activity trajectory information appears in a setting position；
Pain level using preset frequency-pain sensation relationship by frequency translation for animal in setting position；Frequency-the pain sensation
In relationship, frequency is inversely proportional with pain level.
Specifically, this system further includes a vital sign information collection device, for collecting animal by limited area
When vital sign information；Vital sign information includes the body temperature information and blood pressure information of animal.In specific the present embodiment, move
The vital sign informations such as the body temperature information and blood pressure information of object carry out observation note by temperature check instrument, animal blood pressure detector
Record；It is recorded specifically, the respiration information of animal observes the video image by operator, such as in the video of mouse
In image, operator is observed that the depth degree of the breathing of mouse, speed degree namely respiratory rate, and carries out corresponding
Record.
Specifically, this system further includes an environmental information collection device, for obtaining animal when by limited area
Environmental information；Environmental information includes ambient temperature information and environmental voice information.Specifically in the present embodiment, environmental information can
It is recorded by instruments such as the thermometer at laboratory scene and voice detectors.
Specifically, data processing equipment includes a database module, for collecting pain level, vital sign information and ring
Border information, to establish the Pain behaviour database of animal.Specifically, operator is by specific figure group or particular stimulation array
The Pain behaviour of zoopery group carries out comprehensive collection, quantitative assessment and analysis and system according to behavior video observation method
Integration, the more detailed Pain behaviour database of the animal subject can be established.
During establishing Pain behaviour database, in addition to being acquired, encoding to pain expression and index of correlation
Collection, it is also necessary to collect and integrate the information such as other Pain behaviours, and corresponding environmental information, physical signs.
The foundation of Pain behaviour database and perfect, no matter for further exploring the generation base of pain and related disease
Plinth, or the repulsion, adaptation or the evolutionary mechanism that generate for understanding various pain responses, all have very important significance.Tool
Body, which not only includes behavior video collected, encoded information, time and intensity index etc., also comprising being occurred
Various Pain behaviours react (such as limb action, body posture, sounding), physical signs (such as disease model, level of consciousness, body
Sign) and living environment (hot and cold, noisy, quiet).By establishing comprehensive, complete behavior database, can include in various rings
Border or in the case of, have particular physiological characteristic individual pain expression behavior pattern and event coping style.Because of pain
Behavior is a kind of important rodent pain expression way, can describe ANIMAL PAIN perception, emotional state and answer other side
The real picture of formula, but the existing understanding for pain expression also shows slightly insufficient, through this embodiment in Pain behaviour database
Establish perfect, behavior coding, decoding scheme are continued to optimize, for the description of Pain behaviour feature more accurate, are showed
Information also will more enrich.
A kind of ANIMAL PAIN test macro, passes through the video information to animal through stimulation oversaturation needle region disclosed in the present embodiment
It is obtained, then the pain level of animal is analyzed by the activity trajectory information of animal, effectively animal can be pierced
The pain sensation that swashing needle is stimulated is tested and is quantified, and provides research information abundant for the pain research of animal, is conducive to increase
The accuracy and sensitivity of experiment reduce experimental error, and guarantee the objectivity of pain test result.
Embodiment 2
As shown in figure 4, present embodiment discloses it is a kind of using ANIMAL PAIN test macro disclosed in embodiment 1 carry out
ANIMAL PAIN test method comprising following steps；
S1, animal subject is placed on carry out activity in the behaviour area of test cabinet.
Specifically, the structure of test cabinet is identical as the test cabinet in embodiment 1, details are not described herein.
S2, video information of the animal in activity is obtained using camera.
Specifically, the structure and function of camera is identical as the camera in embodiment 1, details are not described herein.
S3, video information is handled by data processing equipment, analysis obtains the activity trajectory information of animal, according to preset
Analysis rule obtains animal in the pain level of the specific position of limited area to activity trajectory information analysis.
Specifically, the data processing equipment in the functional module structure and corresponding function of data processing equipment and embodiment 1
Identical, details are not described herein.
S4, pain level, vital sign information and environmental information are collected, to establish the Pain behaviour database of animal.
Specifically, related to the progress of environmental information collection module by the vital sign information collection module in embodiment 1
The collection of information, and pass through the foundation of database module progress Pain behaviour database.
Specifically, system module used in above-mentioned steps discloses in embodiment 1, details are not described herein.
ANIMAL PAIN test method disclosed in the present embodiment, because it is based on making to system disclosed in embodiment 1
With method, therefore its advantages are similar to Example 1, and details are not described herein.
The preferred embodiment of the present invention has been described in detail above, it should be understood that the commonsense method personnel of this field without
It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, method in all this method fields
Personnel pass through logic analysis, reasoning or available according to limited experiment according to present inventive concept on the basis of existing method
Method scheme, should be among the protection scope determined by the claims.
Claims (10)
1. a kind of ANIMAL PAIN test macro characterized by comprising
Animal activity device, including the limited area for animal activity, the limited area is provided with multiple thorns of array distribution
Swash needle；
Video acquisition device, for obtaining video information of animal when by the limited area；
Data processing equipment, for handling the video information, analysis obtains the activity trajectory information of animal, and according to preset
Analysis rule obtains the pain level of specific position of the animal in the limited area to the activity trajectory information analysis.
2. ANIMAL PAIN test macro according to claim 1, which is characterized in that the animal activity device includes a survey
Try cabinet；The inner space of the test cabinet is divided into behaviour area, and the area pellucida and dark space of the behaviour area two sides is arranged in；
The area pellucida is provided with lighting module so that the brightness in the area pellucida is higher than the first preset threshold；
The dark space, which is provided with, blocks module so that the brightness of the dark space is lower than the second preset threshold；
The ground of the behaviour area is provided with multiple stimulation needles of the array distribution.
3. ANIMAL PAIN test macro according to claim 2, which is characterized in that the array of the behaviour area setting
The needle point area of multiple stimulation needles of distribution, from the side close to the area pellucida to the side close to the dark space, proportionally
Increase or reduces.
4. ANIMAL PAIN test macro according to claim 2, which is characterized in that the data processing equipment includes:
Image processing module handles the video information using image processing algorithm, obtains the image mass center of animal；
Trajectory analysis module counts the motion track of the image mass center of the animal in preset time, obtains animal
In the activity trajectory information of the limited area；
Pain level analysis module obtains animal in the limit to the activity trajectory information analysis according to preset analysis rule
Determine the pain level of the specific position in region.
5. ANIMAL PAIN test macro according to claim 1, which is characterized in that described image Processing Algorithm includes:
Obtain the image of animal in the video information；
To carrying out contours extract after the Yunnan snub-nosed monkey of the animal；
The mass center of the image is obtained by edge calculations.
6. ANIMAL PAIN test macro according to claim 1, which is characterized in that the analysis rule includes:
Calculate the speed that animal in the activity trajectory information passes through a setting position；
Animal is converted in the pain level of the setting position by the speed using preset speed-pain sensation relationship；It is described
In speed-pain sensation relationship, speed is directly proportional to pain level；
And/or
Calculate the frequency that animal in the activity trajectory information appears in a setting position；
Pain level using preset frequency-pain sensation relationship by the frequency translation for animal in the setting position；It is described
In frequency-pain sensation relationship, frequency is inversely proportional with pain level.
7. ANIMAL PAIN test macro according to claim 1, which is characterized in that further include:
Vital sign information collection device, for collecting vital sign information of animal when by the limited area；It is described
Vital sign information includes the body temperature information and blood pressure information, respiration information of animal.
8. ANIMAL PAIN test macro according to claim 7, which is characterized in that further include:
Environmental information collection device, for obtaining environmental information of animal when by the limited area；The environmental information
Including ambient temperature information and environmental voice information.
9. ANIMAL PAIN test macro according to claim 8, which is characterized in that the data processing equipment includes a number
According to library module；
The database module, for collecting the pain level, vital sign information and environmental information, to establish the pain of animal
Pain behavior database.
10. a kind of ANIMAL PAIN test method, by ANIMAL PAIN test macro as claimed in any one of claims 1-9 wherein into
Row is implemented, which comprises the following steps:
Animal is placed on carry out activity in the limited area of animal activity device；The limited area is provided with array distribution
Multiple stimulation needles；
Video information of animal when by the limited area is obtained using video acquisition device；
The video information is handled using data processing equipment, analysis obtains the activity trajectory information of animal, and according to preset
Analysis rule obtains the pain level of specific position of the animal in the limited area to the activity trajectory information analysis.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043533A (en) * | 2020-09-10 | 2020-12-08 | 姬世伟 | A animal vital sign short-term test platform for livestock-raising |
| CN112545464A (en) * | 2020-12-17 | 2021-03-26 | 南京医科大学附属口腔医院 | Quantitative pain detection method and device |
| CN114010155A (en) * | 2021-10-29 | 2022-02-08 | 中山大学 | Automatic animal pain testing system |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005270151A (en) * | 2004-03-23 | 2005-10-06 | Tokumaru:Kk | Health appliance for stimulating body part |
| JP3114909U (en) * | 2005-07-20 | 2005-10-27 | 信建工業株式会社 | Wooden health trail |
| US20060206163A1 (en) * | 2005-03-11 | 2006-09-14 | Wahlstrand Carl D | Neurostimulation site screening |
| CN1915186A (en) * | 2006-09-05 | 2007-02-21 | 徐杰 | Fixing device for experiment of stimulates of senses of pain and heat |
| RU2494673C1 (en) * | 2012-04-23 | 2013-10-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Смоленская государственная медицинская академия" Министерства здравоохранения и социального развития Российской Федерации | Installation for transcutaneous electric pain stimulation of laboratory animals |
| JP2013244387A (en) * | 2012-05-23 | 2013-12-09 | Shingo Hasegawa | Variable pressure point stimulating instrument |
| CN104825135A (en) * | 2015-05-15 | 2015-08-12 | 新乡医学院 | Method for establishing novel pain assessment system |
| CN204654885U (en) * | 2014-11-28 | 2015-09-23 | 叶宁 | Contact pilotage induced pain biological function experiment dolorimeter |
| US20160270364A1 (en) * | 2013-11-01 | 2016-09-22 | Children's Medical Center Corporation | Devices and methods for analyzing rodent behavior |
| CN106037660A (en) * | 2016-06-29 | 2016-10-26 | 中国人民解放军兰州军区兰州总医院 | Mechanical pain sensitivity measurement device |
-
2019
- 2019-08-19 CN CN201910763834.0A patent/CN110522415B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005270151A (en) * | 2004-03-23 | 2005-10-06 | Tokumaru:Kk | Health appliance for stimulating body part |
| US20060206163A1 (en) * | 2005-03-11 | 2006-09-14 | Wahlstrand Carl D | Neurostimulation site screening |
| JP3114909U (en) * | 2005-07-20 | 2005-10-27 | 信建工業株式会社 | Wooden health trail |
| CN1915186A (en) * | 2006-09-05 | 2007-02-21 | 徐杰 | Fixing device for experiment of stimulates of senses of pain and heat |
| RU2494673C1 (en) * | 2012-04-23 | 2013-10-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Смоленская государственная медицинская академия" Министерства здравоохранения и социального развития Российской Федерации | Installation for transcutaneous electric pain stimulation of laboratory animals |
| JP2013244387A (en) * | 2012-05-23 | 2013-12-09 | Shingo Hasegawa | Variable pressure point stimulating instrument |
| US20160270364A1 (en) * | 2013-11-01 | 2016-09-22 | Children's Medical Center Corporation | Devices and methods for analyzing rodent behavior |
| CN204654885U (en) * | 2014-11-28 | 2015-09-23 | 叶宁 | Contact pilotage induced pain biological function experiment dolorimeter |
| CN104825135A (en) * | 2015-05-15 | 2015-08-12 | 新乡医学院 | Method for establishing novel pain assessment system |
| CN106037660A (en) * | 2016-06-29 | 2016-10-26 | 中国人民解放军兰州军区兰州总医院 | Mechanical pain sensitivity measurement device |
Non-Patent Citations (1)
| Title |
|---|
| 张佳瑞: "用联合开放旷场试验评价大脑介导的痛行为", 《中国优秀博硕士学位论文全文数据库(硕士)医药卫生科技辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043533A (en) * | 2020-09-10 | 2020-12-08 | 姬世伟 | A animal vital sign short-term test platform for livestock-raising |
| CN112545464A (en) * | 2020-12-17 | 2021-03-26 | 南京医科大学附属口腔医院 | Quantitative pain detection method and device |
| CN114010155A (en) * | 2021-10-29 | 2022-02-08 | 中山大学 | Automatic animal pain testing system |
| WO2023070701A1 (en) * | 2021-10-29 | 2023-05-04 | 中山大学 | Automatic animal pain test system |
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