CN109938727A - Non-human primate 3D vision stimulation test system and method - Google Patents
Non-human primate 3D vision stimulation test system and method Download PDFInfo
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Abstract
The invention discloses a kind of non-human primate 3D vision stimulation test system and method, which includes: three-dimensional stimulation display module, eye-tracking module, three-dimensional stimulation control module, Neural Signal Collecting module, data integration module；Three-dimensional stimulation control module generates 3D vision stimulation, and 3D vision stimulation is sent to three-dimensional stimulation display module and is shown；Eye-tracking module tracks watch the eye motion of the non-human primate of 3D vision stimulation, obtain eye motion track；The biological neural signal of Neural Signal Collecting module acquisition non-human primate；Data integration module stimulates 3D vision, eye motion track integrates with corresponding biological neural signal and stores.Non-human primate 3D vision stimulation test system and method disclosed by the invention, for obtaining brain network neural activity data of the non-human primate when being stimulated by 3D vision.
Description
Technical field
The present embodiments relate to biomedical technology more particularly to a kind of stimulation of non-human primate 3D vision are real
Check system and method.
Background technique
Brain is the organ that structure is most complicated in biology, is the highest part of nervous system, is the organ of biological thinking,
Dominate in organism the activity of all.In order to explore the secret of brain, physician and biologist to the research of brain always
It is not stopped at.The research of brain suffers from important meaning for the development of artificial intelligence and the treatment of mankind's brain diseases
Justice.
Since the brain of the non-human primates such as monkey, orangutan and the brain construction of the mankind are closely similar, at present
Generally using non-human primate as the object to brain network research.Wherein, cranial nerve perception is research brain to the external world
A kind of experiment for the reaction that different stimulated generates, is studied for the working mechanism to brain network, is that research brain work is former
The important experiment of reason.But carrying out cranial nerve perception experiment to non-human primate at present is typically all using picture to reality
It tests animal and carries out visual stimulus, and to the electroneurographic signal of the reaction and brain network that are stimulated animal, neurochemistry signal etc.
It is tested.
But current cranial nerve perception experimental method does not provide true visual stimulus to experimental animal, so that testing
To test data be not visual stimulus of the experimental animal to natural conditions feedback, people can not learn from non-natural, mistake
The experimental result obtained in simplified environment to what extent discloses the working principle of brain network on earth.
Summary of the invention
The present invention provides a kind of non-human primate 3D vision stimulation test system and method, to realize to inhuman spirit
Long class animal carries out 3D vision stimulation test, obtains brain network mind of the non-human primate when being stimulated by 3D vision
Through activity data.
In a first aspect, the embodiment of the present invention provides a kind of non-human primate 3D vision stimulation test system, comprising:
Three-dimensional stimulation display module, eye-tracking module, three-dimensional stimulation control module, Neural Signal Collecting module, data integration module；
The three-dimensional stimulation control module is sent to institute for generating 3D vision stimulation, and by 3D vision stimulation
State three-dimensional stimulation display module；
The three-dimensional stimulation display module is for showing the 3D vision stimulation；
The eye-tracking module is used for the tracking when the three-dimensional stimulation display module shows 3D vision stimulation
The eye motion of the non-human primate of the 3D vision stimulation is watched, and eye motion track is sent to the data
Integration module；
The Neural Signal Collecting module is used for when the three-dimensional stimulation display module shows 3D vision stimulation,
The biological neural signal of the non-human primate of the 3D vision stimulation is watched in acquisition, and the biological neural signal is sent out
It send to the data integration module；
The data integration module is used for 3D vision stimulation, the eye motion track and corresponding biology is refreshing
Through the integrated storage of signal.
In a kind of possible implementation of first aspect, the eye-tracking module is also used to eye motion described
Track is sent to the three-dimensional stimulation control module；
The three-dimensional stimulation control module is also used to be determined according to the eye motion track when the viewing 3D vision
When the non-human primate of stimulation watches the central region of the three-dimensional stimulation display module attentively, the three-dimensional stimulation display is controlled
Module shows the 3D vision stimulation.
In a kind of possible implementation of first aspect, the experimental system further include: award control module is used for root
According to the control of the three-dimensional stimulation control module, food prize is provided to watch the non-human primate of the 3D vision stimulation
It encourages；
The three-dimensional stimulation control module is specifically used for determining when the non-human primates for watching the 3D vision stimulation are dynamic
When object watches the central region of the three-dimensional stimulation display module attentively, according to logic of propositions, the three-dimensional stimulation display module is controlled
It shows the 3D vision stimulation, and obtains the eye motion track of the eye-tracking module tracks, if the eye motion
Track meets predetermined movement track rule, then controls the inhuman spirit that the award control module is the viewing 3D vision stimulation
Long class animal provides food reward.
In a kind of possible implementation of first aspect, the three-dimensional stimulation display module includes wear-type Three-dimensional Display
Glasses, the eye-tracking module include eye-tracking camera, and the eye-tracking camera is integrated in the wear-type three
In dimension display glasses, composition wear-type is visually equipped, and the wear-type visually equips and watches the non-of the 3D vision stimulation
The matching of people primate.
In a kind of possible implementation of first aspect, the Neural Signal Collecting module, including nerve cell optics
Submodule and/or neurotransmitter detection sub-module is imaged；
The non-human primates that the nerve cell optical imagery submodule is used to obtain the viewing 3D vision stimulation are dynamic
The cranial nerve cell functional imaging of object；
The neurotransmitter detection sub-module is used to detect the non-human primate for watching the 3D vision stimulation
Concentration of neurotransmitters.
Second aspect, the embodiment of the invention also provides a kind of non-human primate 3D vision stimulation test method,
Include:
3D vision stimulation is generated, and shows the 3D vision stimulation；
The eye motion of the non-human primate of the 3D vision stimulation is watched in tracking, obtains eye motion track；
Judge the non-human primate for watching the 3D vision stimulation whether to institute according to the eye motion track
It states 3D vision stimulation and generates expected eye movement behavior；
The biological neural signal of the non-human primate of the 3D vision stimulation is watched in acquisition；
3D vision stimulation, the eye motion track are integrated into storage with corresponding biological neural signal.
In a kind of possible implementation of second aspect, the display 3D vision stimulation, comprising:
According to the eye motion track, determine when the non-human primate for watching the 3D vision stimulation watches view attentively
When the heart of Yezhong, the 3D vision stimulation is shown.
It is described according to the eye motion track in a kind of possible implementation of second aspect, it determines when viewing institute
When stating the non-human primate visual field of fixation center of 3D vision stimulation, the 3D vision stimulation is shown, comprising:
It determines when watching the non-human primate visual field of fixation center of the 3D vision stimulation, is patrolled according to default
Volume, show the 3D vision stimulation；
The eye motion of the non-human primate of the 3D vision stimulation is watched in the tracking, obtains eye motion rail
After mark, the method also includes:
If the eye motion track meets predetermined movement track rule, to watch the inhuman of the 3D vision stimulation
Primate provides food reward.
In a kind of possible implementation of second aspect, the inhuman spirit that the 3D vision stimulation is watched in the acquisition is long
The biological neural signal of class animal, comprising:
Obtain the cranial nerve cell functional imaging for watching the non-human primate of the 3D vision stimulation, and/or inspection
Survey the concentration of neurotransmitters for watching the non-human primate of the 3D vision stimulation.
In a kind of possible implementation of second aspect, the method also includes:
The limb activity of the non-human primate of the 3D vision stimulation is watched in detection；
3D vision stimulation, the eye motion track are wrapped with to the integrated storage of corresponding biological neural signal
It includes:
By 3D vision stimulation, the eye motion track and corresponding biological neural signal and limb activity collection
At storage.
Non-human primate 3D vision stimulation test system and method provided in an embodiment of the present invention are stimulated by three-dimensional
The three-dimensional stimulation display module of control module control shows 3D vision stimulation, and by eye-tracking module to viewing 3D vision thorn
The eye motion track of sharp non-human primate is tracked, so that the non-human primate of viewing 3D vision stimulation
The visual stimulus very close with natural forms can be obtained, Neural Signal Collecting module acquisition non-human primate is reused
Biological neural signal when watching 3D vision stimulation, so as to obtain the brain network visual stimulus of non-human primate
Experimental data provides for the working principle for disclosing brain network for the exploitation of artificial intelligence and the Clinics and Practices of cerebral disorders
Important data are supported.
Detailed description of the invention
Fig. 1 is the knot of non-human primate 3D vision stimulation test system embodiment one provided in an embodiment of the present invention
Structure schematic diagram；
Fig. 2 is the knot of non-human primate 3D vision stimulation test system embodiment two provided in an embodiment of the present invention
Structure schematic diagram；
Fig. 3 is the stream of non-human primate 3D vision stimulation test embodiment of the method one provided in an embodiment of the present invention
Cheng Tu.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
Research movable for brain network neural needs to apply environmental stimuli to living body biological, then to different extraneous thorns
The activity for swashing corresponding brain network is recorded, and different environmental stimulis and the movable corresponding relationship of brain network neural are therefrom found,
To disclose the working principle of brain network.It much requires to carry out invasive reality to living body since the activity to brain network detect
It tests, cannot be tested on living human, and the brain network of non-human primate, such as monkey, orangutan etc. and mankind's phase
Seemingly, therefore, general at present all to carry out the movable experiment of brain network neural using non-human primate.
In the movable experiment of progress brain network neural, environmental stimuli is generally used visual stimulus, this is because vision
Stimulation is more intuitive, and changes and enrich, obvious to the stimulation of non-human primate.It but is at present typically all to use two-dimension picture
Visual stimulus is carried out to non-human primate, and the activity of brain network is recorded, that is, is long to the inhuman spirit such as monkey
Class animal watches different pictures, then tests the associated biomolecule nerve signal situation of change of the brain network of monkey.But X-Y scheme
Still there is gap in the object in piece and natural environment, the experimental result that current brain network experiment obtains can't be anti-well
Answer the working principle of brain network.
The embodiment of the present invention provides a kind of non-human primate 3D vision stimulation test system, will be to non-human primates
The visual stimulus of the brain network neural active experiment of animal is changed into 3D vision stimulation from two-dimension picture, thus more preferable simulation
The visual stimulus of natural environment obtains the true feedback of visual stimulus of the brain network to natural environment, to preferably disclose brain
The working principle of network.
Fig. 1 is the knot of non-human primate 3D vision stimulation test system embodiment one provided in an embodiment of the present invention
Structure schematic diagram, as shown in Figure 1, experimental system provided in this embodiment includes: three-dimensional stimulation display module 11, eye-tracking module
12, three-dimensional stimulation control module 13, Neural Signal Collecting module 14, data integration module 15.
Wherein, three-dimensional stimulation display module 11 and eye-tracking module 12 are connect with three-dimensional stimulation control module 13 respectively,
Neural Signal Collecting module 14 and three-dimensional stimulation control module 13 are connect with data integration module 15 respectively, eye-tracking module 12
Also it is connect with data integration module 15.
Three-dimensional stimulation control module 13 is sent to three-dimensional stimulation for generating 3D vision stimulation, and by 3D vision stimulation
Display module 11；Three-dimensional stimulation display module 11 is for showing that 3D vision stimulates.Due to long to inhuman spirit using two-dimension picture
Class animal carries out visual stimulus, and the picture of non-human primate viewing and gap in kind under natural conditions are larger, then brain
The active state of nerve also it is inevitable with watch the state of actual object inconsistent.Therefore, in the present embodiment, stimulated by three-dimensional
Control module 13 generates 3D vision stimulation, and shows 3D vision stimulation using three-dimensional stimulation display module 11.Due to three-dimensional
The display of visual stimulus and the gap of natural forms are smaller, therefore, when non-human primate watches 3D vision to stimulate,
The active state of brain network by with watch state when actual object more close, at this time to viewing 3D vision stimulation it is non-
The active state of the brain network of people primate records, then available brain network is to different 3D vision stimulations
Reactiveness.
Three-dimensional stimulation display module 11 can be any device that can be realized Three-dimensional Display, such as three-dimensional aobvious
Show glasses, naked eye 3D display equipment etc..Actual needs of the three-dimensional stimulation control module 13 according to three-dimensional stimulation display module 11, life
Content is stimulated at the 3D vision that three-dimensional stimulation display module 11 can be shown.And three-dimensional stimulation control module 13 need according into
The type of the non-human primate of row test, according to certain logic, generation is suitable for non-human primate viewing, and
Visual stimulus can be carried out to non-human primate.
In order to enable the non-human primate for watching 3D vision stimulation that more true 3D vision to be watched to pierce
Swash, the 3D vision stimulation that three-dimensional stimulation display module 11 plays is to be shot by three-dimensional stimulation control module 13 according to video camera
Picture construction go out.The key step that three-dimensional stimulation control module 13 carries out 3D vision stimulation building includes: that 1, image obtains
It takes, the acquisition of image is the basis of three-dimensional reconstruction, and the mode of acquisition is mainly shot by video camera, to consider to regard when obtaining
The factors such as angle, illumination, camera performance, in favor of subsequent reconstruction calculating.2, camera calibration, the position including determining video camera
It sets and attribute.One effective camera model is conducive to the three-dimensional information for accurately recovering space scenery.3, feature mentions
It takes, feature refers to pixel or pixel set, and common matching characteristic includes point-like character, line feature and provincial characteristics etc..Generally
For, large-scale characteristics contains more rich information, and number is less, readily available Rapid matching, but description of them is opposite
Complexity, positioning accuracy are also poor；Small scale features positioning accuracy is high, and expression description is simple, but number is more, information contained amount compared with
It is few.4, Stereo matching determines 3D information by the parallax of multiple views, it is thus necessary to determine that pair of the same object point in different images in scene
It should be related to.Stereo matching is basis to the corresponding relationship between selected feature and feature, by the same spatial point in different images
Photosites be mapped, and thus obtain corresponding anaglyph.5, depth information determines, the view obtained using Stereo matching
Difference image determines image depth information and restoration scenario 3D information.6, it post-processes, including depth interpolation, error correction and surface
Processing etc..The final purpose of three-dimensional reconstruction is to restore the complete information of scenery visible surface.
3D vision stimulation test is carried out since experimental system provided in this embodiment is used to non-human primate,
It is difficult to predict in order to improve conventional efficient, three-dimensional stimulation display module 11 can use the active state of non-human primate
Wear-type Three-dimensional Display glasses.Wear-type Three-dimensional Display glasses are fixed after being worn on non-human primate head, it is no matter inhuman
How the head of primate moves, and can make it that the 3D vision shown in wear-type Three-dimensional Display glasses be watched to pierce
Swash.
Eye-tracking module 12 is used for when three-dimensional stimulation display module 11 shows 3D vision stimulation, and tracking viewing is three-dimensional
The eye motion of the non-human primate of visual stimulus, and eye motion track is sent to data integration module 15.When three
When dimension stimulation display module 11 shows 3D vision stimulation, the inhuman spirit of the tracking viewing 3D vision stimulation of eye-tracking module 12
The eye motion of long class animal gets off the eye motion track record, and the eye motion track of record is sent to data
Integration module 15.Since non-human primate is when watching 3D vision stimulation, whether eyes watch the 3D vision of broadcasting attentively
The different location of stimulation and eye gaze, all indicates the differential responses that non-human primate stimulates the 3D vision.
Eye motion track and 3D vision stimulation when therefore, by non-human primate viewing 3D vision stimulation store jointly
Come, support can be provided for the brain network research to non-human primate.Eye-tracking module 12 can be high-speed camera,
High-speed camera shooting obtains eye image information, and eye image information input to eye movement computer is calculated eye position
Information.
Neural Signal Collecting module 14 is used for the acquisition viewing when three-dimensional stimulation display module 11 shows 3D vision stimulation
The biological neural signal of the non-human primate of 3D vision stimulation, and biological neural signal is sent to data integration module
15.The brain network of non-human primate is similar to the mankind's, and structure is sufficiently complex, when brain network carry out activity, inhuman spirit
The long intracorporal multiple organs of class animal can all work, and there are many neural power information of non-human primate, nerve information etc.
Changes will occur for biological neural information.Neural Signal Collecting module 14 can be to the non-human primates of viewing 3D vision stimulation
At least one biological neural signal of animal is acquired, to obtain reflection non-human primate in viewing 3D vision thorn
Brain network neural activity data when swashing.
Neural Signal Collecting module 14 can for example acquire the cranial nerve cell optical imagery of non-human primate, obtain
Cranial nerve cell function optical imagery.The nerve that for example Neural Signal Collecting module 14 can acquire non-human primate again is passed
Matter concentration.Neural Signal Collecting module 14 is according to the type of the biological neural signal of required acquisition, by different sensor and letter
Number acquisition device composition, the specific structure and function of Neural Signal Collecting module 14 are described in detail in the examples described below.
Three-dimensional stimulation control module 13, eye-tracking module 12 and Neural Signal Collecting module 14 respectively pierce 3D vision
The biological neural signal of sharp, eye motion track and acquisition is sent to data integration module 15, and data integration module 15 will acquire
The biological neural signal arrived is integrated with 3D vision stimulation corresponding when acquiring the biological neural signal and eye motion track
It together and stores, has thus obtained the reaction and life when different 3D vision stimulations, viewing 3D vision stimulation
The corresponding relationship of object nerve signal.
The brain that the data stored in data integration module 15, as non-human primate stimulate different 3D visions
Network function situation of change, after collecting sufficient amount of data, can to the data stored in data integration module 15 into
Row analysis, so that the working mechanism analysis to brain network provides more accurately and reliably data.Due to non-human primate
Brain net structure is similar with the mankind, analyzes the collected data of experimental system provided in an embodiment of the present invention, Neng Gouwei
The research of artificial intelligence and the diagnosing and treating of mankind's brain diseases provide support.
Non-human primate 3D vision stimulation test system provided in an embodiment of the present invention is stimulated by three-dimensional and controls mould
The three-dimensional stimulation display module of block control shows 3D vision stimulation, and by eye-tracking module to the non-of viewing 3D vision stimulation
The eye motion track of people primate tracks, and the non-human primate of viewing 3D vision stimulation is obtained
To the visual stimulus very close with natural forms, reuses Neural Signal Collecting module acquisition non-human primate and watching
Biological neural signal when 3D vision stimulates, so as to obtain the brain network vision stimulation test number of non-human primate
According to being provided for the exploitation of artificial intelligence and the Clinics and Practices of cerebral disorders important for the working principle for disclosing brain network
Data are supported.
In experimental system shown in Fig. 1, in order to ensure the non-human primate tested can be watched accurately
The 3D vision stimulation that three-dimensional stimulation display module 11 is shown, three-dimensional stimulation control module 13 also connect with eye-tracking module 12
It connects, obtains the eye motion track that eye-tracking module 12 acquires.Since the non-human primate only ensured in testing is seen
See that the 3D vision stimulates, the biological characteristic of the brain network got can accurately reflect non-human primate to broadcasting
3D vision stimulation the activity of brain network neural.Therefore, the tracking of eye-tracking module 12 viewing 3D vision stimulation is inhuman
The eye motion of primate, and the eye motion track traced into is sent to three-dimensional stimulation control module 13, make three-dimensional
Stimulation control module 13 determines whether the non-human primate in experiment has watched the 3D vision stimulation played.In addition,
Three-dimensional stimulation control module 13 can determine after receiving the collected eye motion track of eye-tracking module 12 when viewing
When the non-human primate of 3D vision stimulation watches the central region of three-dimensional stimulation display module 11 attentively, it is aobvious to control three-dimensional stimulation
Show that module 11 shows 3D vision stimulation.The 3D vision that may insure that three-dimensional stimulation display module 11 is shown in this way is stimulated by reality
Non-human primate in testing is watched, to ensure the accuracy of experimental data.
Fig. 2 is the knot of non-human primate 3D vision stimulation test system embodiment two provided in an embodiment of the present invention
Structure schematic diagram, as shown in Fig. 2, experimental system provided in this embodiment on the basis of Fig. 1, further includes award control module 16.
Award control module 16 is connect with three-dimensional stimulation control module 13, for the control according to three-dimensional stimulation control module 13, to see
See that the non-human primate of 3D vision stimulation provides food reward.Three-dimensional stimulation control module 13 is specifically used for receiving
Behind the collected eye motion track of eye-tracking module 12, the non-human primate note when viewing 3D vision stimulation is determined
When depending on the three-dimensional central region for stimulating display module 11, according to logic of propositions, controls three-dimensional stimulation display module 11 and show three-dimensional
Visual stimulus, and the eye motion track of the tracking of eye-tracking module 12 is obtained, if eye motion track meets predetermined movement rail
Mark rule, the then non-human primate for controlling award control module 16 as viewing 3D vision stimulation provide food reward.
Since the experimental subjects of experimental system provided in an embodiment of the present invention is the non-human primates such as monkey, orangutan,
And these non-human primates and to be tamed completely, in order to enable the non-human primate for participating in experiment to cooperate completion
Experiment, needs to provide certain reward mechanism for it, its cooperation can be made to complete experiment.And for non-human primate,
The effect rewarded with food it is best, and therefore, experimental system provided in this embodiment increases award control module 16,
Award control module 16 is connect with three-dimensional stimulation control module 13.When three-dimensional stimulation control module 13 controls three-dimensional stimulation display mould
After block 11 shows 3D vision stimulation, three-dimensional stimulation control module 13 obtains the eye motion rail that eye-tracking module 12 tracks
Mark, judges whether the eye motion track for watching the non-human primate of 3D vision stimulation meets default rule, also
It is to judge whether the non-human primate for watching 3D vision stimulation has watched attentively in the 3D vision stimulation played it is expected to be infused
Depending on position.If meeting above-mentioned rule, it is viewing 3D vision that three-dimensional stimulation control module 13, which controls award control module 16,
The non-human primate of stimulation provides food reward, such as a small amount of fruit or a small amount of fruit juice etc..If watching 3D vision stimulation
The eye motion track of non-human primate do not meet preset motion profile rule, then awarding control module 16 will not be
It provides food reward.
The regular hour is needed due to carrying out brain network stimulation test to non-human primate every time, needs to watch three-dimensional
The non-human primate of visual stimulus watches the long period, in addition, Neural Signal Collecting module 14 is in order to believe biological neural
It number is acquired, it is also desirable to some sensors are installed in the internal or body surface of non-human primate.It so needs testing
Cheng Zhong, the non-human primate for participating in experiment not move.Therefore, experimental system provided in an embodiment of the present invention, it is preferable that
Using Three-dimensional Display glasses as three-dimensional stimulation display module 11, and awards control module 16 and be fixed on three-dimensional stimulation display module
On 11, and the oral cavity of the non-human primate of Three-dimensional Display glasses is worn in the alignment of food delivery outlet.Inhuman spirit is long every time in this way
Class animal has been watched attentively when needing the content watched attentively in three-dimensional stimulation display module 11, and three-dimensional stimulation control module 13 controls award
Food of the control module 16 to the oral cavity of non-human primate output fixed capacity.The non-human primates for so participating in experiment are dynamic
Object can cooperate completion to test.
It is the visual stimulus of brain network in invention the present embodiment in conjunction with the relationship between visual stimulus and brain network function
Three kinds of experimental duties have been formulated in experiment, are 3D vision stimulation perception experiment, 3D vision stimulation identification experiment, three-dimensional view respectively
Feel search experiment.These three experiments are vision and the movable several basic combinations of brain network neural.Three-dimensional stimulation control module 13
Respectively different 3D visions is formulated in these three experiments stimulates display logic, makes three-dimensional stimulation display module 11 according to certain
Sequence and mode show that 3D vision stimulates.3D vision stimulation display logic can according to experiment demand difference, experiment
The difference of animal is designed.In embodiments of the present invention, a kind of feasible 3D vision is provided respectively for three kinds of experimental duties
Stimulate display logic.
Wherein, it is stimulated in perception experiment in 3D vision, stimulation control module 13 three-dimensional first needs to pass through eye-tracking
The tracking result of module 12, determines whether experimental animal is look at a bright spot of central region, when to watch this attentively bright for experimental animal
After one preset duration of point (such as 400 milliseconds), a 3D vision stimulation is shown in the position far from central region, is presented one
(such as 200 milliseconds) disappear after a preset duration；Using (such as 100 milliseconds) after a preset duration, far from the visual field
Another position of the heart shows the stimulation of 3D vision, and (such as 200 milliseconds) disappear after being presented a preset duration；With such
It pushes away, after presenting the stimulation of several 3D visions (such as 5), if experimental animal still watches the bright spot, three-dimensional thorn attentively
Swash the control award control module 16 of control module 13 and provides the food of fixed capacity to experimental animal.If during the experiment,
The blinkpunkt of experimental animal leaves the bright spot, then 3D vision stimulation all in three-dimensional stimulation display module 11 is closed,
After the preset duration of interval (such as 800 milliseconds), experiment restarts.Wherein, eye-tracking module 12 is real-time during the experiment
The movements binocular track of tracking test animal, so that it is determined that the blinkpunkt of experimental animal.This experiment can be to non-human primates
Brain network neural active state of the animal when concentrating fixation object is tested.
It is stimulated in identification experiment in 3D vision, stimulation control module 13 three-dimensional first is needed through eye-tracking module 12
Tracking result, determine whether experimental animal is look at a bright spot of central region, when experimental animal watches the bright spot one attentively
After preset duration (such as 500-1500 milliseconds), multiple 3D vision stimulations (such as 6), Duo Gesan are shown simultaneously in the visual field
It ties up in visual stimulus, one has slight difference with the stimulation of other 3D visions in shape, and the stimulation of other 3D visions is phase
With.Experimental animal has certain duration (such as 1000 milliseconds) to identify the stimulation of these 3D visions, if in the duration
Interior, the blinkpunkt of experimental animal is skipped to stimulates different 3D visions to stimulate from other 3D visions, then three-dimensional stimulation control
The control award control module 16 of module 13 provides the food of fixed capacity to experimental animal.If in the duration, experimental animal
Blinkpunkt skip in other same 3D vision stimulation, or the blinkpunkt of experimental animal is not anti-after the duration
It answers, then 3D vision stimulation all in three-dimensional stimulation display module 11 is closed, after being spaced preset duration (such as 800 millis
Second), experiment restarts.Wherein, the movements binocular rail of the real-time tracking experimental animal during the experiment of eye-tracking module 12
Mark, so that it is determined that the blinkpunkt of experimental animal.This experiment can be to brain of the non-human primate when differentiating different target
Network neural active state is tested.
In 3D vision search experiment, three-dimensional first stimulation control module 13 need by eye-tracking module 12 with
Track as a result, determine whether experimental animal is look at a bright spot of central region, when experimental animal watch attentively the bright spot one it is default
After duration (such as 500 milliseconds), a 3D vision stimulation is shown as search target, when one, interval is default in central region
After length (such as 500-1500 milliseconds), the 3D vision of central region, which stimulates, to disappear, in the process the note of tracking test animal
Whether viewpoint moves, and tests and restarts if mobile.If the blinkpunkt of experimental animal does not move, three-dimensional stimulation display module
11 are presented a 3 D stereo scene in the visual field of experimental animal, and the 3D vision stimulation as search target appears randomly in
Any position of 3 D stereo scene, the eye motion track of 12 tracking test animal of eye-tracking module, judges pre- at this time
If in duration the blinkpunkt of (such as 4 seconds) experimental animal whether can be moved to the search target and maintain certain time length (such as
500 milliseconds).If experimental animal finds search target in preset duration, three-dimensional stimulation control module 13 controls award control
Module 16 provides the food of fixed capacity to experimental animal.If do not found, all three in three-dimensional stimulation display module 11
Dimension visual stimulus is closed, and after being spaced preset duration (such as 800 milliseconds), experiment restarts.Wherein, eye-tracking module
The movements binocular track of 12 real-time tracking experimental animals during the experiment, so that it is determined that the blinkpunkt of experimental animal.This reality
Brain network neural active state of the non-human primate when searching for sensation target can be tested by testing.
Further, three-dimensional stimulation display module 11 preferably uses wear-type Three-dimensional Display glasses, eye-tracking module
12 are realized using eye-tracking camera.So for the eye motion track of tracking test animal, can will as eye movement with
The eye-tracking camera of track module 12 is integrated in wear-type Three-dimensional Display glasses, forms wear-type visual device.This is worn
Formula visual device needs to match with the non-human primate of viewing 3D vision stimulation, and matching here includes external form and size
Matching, allow wear-type visual device fix be worn on need participate in experiment non-human primate head on, also need
It to be matched in view of display module corresponding with eyes with parameters such as the interpupillary distance of experimental animal eyes, diopter, sensitivity.
In Fig. 1 and embodiment illustrated in fig. 2, Neural Signal Collecting module 14 is used for the inhuman of viewing 3D vision stimulation
The biological neural signal of primate is acquired, biological neural signal it is many kinds of, including a variety of electroneurographic signals,
The biological neural signal type of neurochemistry signal etc., acquisition is more, it will be able to more accurately and completely react brain network
Activity.But applicant has found under study for action, is imaged and detects in somatic nerves mediator, the work to brain network in somatic nerves cell function
Dynamic research is most valuable.Therefore, Neural Signal Collecting module 14 may include nerve cell optical imagery submodule and/or nerve
Mediator detection sub-module.
Wherein, nerve cell optical imagery submodule is imaged for carrying out in somatic nerves cell function, to nerve cell
Activity is directly observed and is recorded.In embodiments of the present invention, it is carried out using fiber fluorescence micro imaging method in body mind
It is imaged through cell function, nerve cell optical imagery submodule is realized using optical-fiber type single photon fluorescence micro-endoscope.Pass through
By in optical-fiber type single photon fluorescence micro-endoscope implantation experiment animal brain, the point by point scanning tissue in the plane of intracerebral, every point
A corresponding excitation signal, the excitation signal are emitted by continuous source, successively deflect and be injected into an optical fiber of image-carrying fiber bundle
It is interior, it is then focused in above-mentioned plane in exit, described every is transferred transmitting fluorescence signal, and the fluorescence signal is by same root light
Fibre is collected, and carries out detection and digitized processing, then to form pixel.
For neurotransmitter detection sub-module for detecting in somatic nerves mediator concentration, neurotransmitter is dashed forward in nervous system
The particular chemicals, such as dopamine, adrenaline etc. for touching transmitting, are accurately detected in somatic nerves mediator concentration, to brain net
The activity of network equally has huge meaning.In embodiments of the present invention, it for detecting in body dopamine and aminoglutaric acid concentration, adopts
Carbon fiber electrode is used to be mentioned as the matrix of Dopamine Sensor by Dopamine Sensor implantation experiment animal body by modification
Highly sensitive and anti-interference ability, detects its concentration in conjunction with fast cyclic voltammetry；Using metal platinum microelectrode as paddy
The matrix of propylhomoserin is realized in glutaminic acid sensor implantation experiment animal body by modification dglutamic oxidase to glutamic acid spy
It identifies, its concentration is detected anisotropicly in conjunction with potentiostatic method.Neurotransmitter sensor is coupled with photoelectrode array, is excluded
It interferes with each other, establishes perfect regulation and measurement method, realize neuromodulation and the neurotransmitter detection of living body level.
What nerve cell optical imagery submodule and/or neurotransmitter detection sub-module acquired is the neural living of experimental animal
Dynamic or neurochemistry signal, Neural Signal Collecting module 14 can also be for example the device or module of acquisition bioelectrical signals, example
Such as acquire EEG signals, the electromyography signal of experimental animal.
Further, in Fig. 1 and experimental system shown in Fig. 2, can also increase to the inhuman of viewing 3D vision stimulation
The module that the limb motion of primate is detected, such as the gloves for detecting hand exercise are taken to experimental animal,
Or increase motion sensor in integrated wear-type Three-dimensional Display glasses, the head movement of experimental animal is detected
Deng.The limb motion of the non-human primate of obtained viewing 3D vision stimulation equally with corresponding three-dimensional stimulation is corresponding deposits
Storage, the abundant data class that brain network neural activity is studied.
Fig. 3 is the stream of non-human primate 3D vision stimulation test embodiment of the method one provided in an embodiment of the present invention
Cheng Tu, as shown in figure 3, experimental method provided in this embodiment includes:
Step S301 generates 3D vision stimulation, and shows that 3D vision stimulates.
Step S302, the eye motion of the non-human primate of tracking viewing 3D vision stimulation, obtains eye motion
Track.
Whether step S303 judges the non-human primate for watching 3D vision stimulation to three according to eye motion track
It ties up visual stimulus and generates expected eye movement behavior.
Step S304, the biological neural signal of the non-human primate of acquisition viewing 3D vision stimulation.
3D vision stimulation, eye motion track are integrated storage with corresponding biological neural signal by step S305.
Non-human primate 3D vision stimulation test method provided in this embodiment can use shown in FIG. 1 inhuman
Primate 3D vision stimulation test system detects the brain network neural activity of non-human primate, specific
Implementation method and technical effect are elaborated in the embodiment shown in fig. 1, and details are not described herein again.
Further, on the basis of embodiment shown in Fig. 3, display 3D vision stimulation, comprising: according to eye motion rail
Mark is determined when watching the non-human primate visual field of fixation center of 3D vision stimulation, shows the 3D vision stimulation.
Further, it on the basis of embodiment shown in Fig. 3, according to eye motion track, determines when viewing 3D vision
When the non-human primate visual field of fixation center of stimulation, display 3D vision stimulation, comprising: according to eye motion track, really
When the non-human primate visual field of fixation center of settled viewing 3D vision stimulation, according to logic of propositions, 3D vision is shown
Stimulation；The eye motion of the non-human primate of tracking viewing 3D vision stimulation, after obtaining eye motion track, the reality
Proved recipe method further include: if eye motion track meets predetermined movement track rule, for the inhuman spirit of viewing 3D vision stimulation
Long class animal provides food reward.
Further, on the basis of embodiment shown in Fig. 3, the non-human primate of acquisition viewing 3D vision stimulation
Biological neural signal, comprising: obtain viewing 3D vision stimulation non-human primate cranial nerve cell functional imaging,
And/or the concentration of neurotransmitters of the non-human primate of detection viewing 3D vision stimulation.
Further, on the basis of embodiment shown in Fig. 3, the experimental method further include: detection viewing 3D vision thorn
The limb activity of sharp non-human primate；By 3D vision stimulation, eye motion track and corresponding biological neural signal
And the integrated storage of limb activity.
By the description above with respect to embodiment, it is apparent to those skilled in the art that, the present invention
It can be realized by software and required common hardware, naturally it is also possible to which by hardware realization, but in many cases, the former is more
Good embodiment.Based on this understanding, technical solution of the present invention substantially in other words contributes to the prior art
Part can be embodied in the form of software products, which can store in computer readable storage medium
In, floppy disk, read-only memory (Read-Only Memory, ROM), random access memory (Random such as computer
Access Memory, RAM), flash memory (FLASH), hard disk or CD etc., including some instructions are with so that a computer is set
Standby (can be personal computer, server or the network equipment etc.) executes method described in each embodiment of the present invention.
It is worth noting that, included each unit and module are only according to function in the embodiment of above-mentioned searcher
Energy logic is divided, but is not limited to the above division, as long as corresponding functions can be realized；In addition, each function
The specific name of energy unit is also only for convenience of distinguishing each other, the protection scope being not intended to restrict the invention.
Note that the above is only a better embodiment of the present invention and the applied technical principle.It will be appreciated by those skilled in the art that
The invention is not limited to the specific embodiments described herein, be able to carry out for a person skilled in the art it is various it is apparent variation,
It readjusts and substitutes without departing from protection scope of the present invention.Therefore, although being carried out by above embodiments to the present invention
It is described in further detail, but the present invention is not limited to the above embodiments only, without departing from the inventive concept, also
It may include more other equivalent embodiments, and the scope of the invention is determined by the scope of the appended claims.
Claims (10)
1. a kind of non-human primate 3D vision stimulation test system characterized by comprising three-dimensional stimulation display mould
Block, eye-tracking module, three-dimensional stimulation control module, Neural Signal Collecting module, data integration module；
The three-dimensional stimulation control module is sent to described three for generating 3D vision stimulation, and by 3D vision stimulation
Dimension stimulation display module；
The three-dimensional stimulation display module is for showing the 3D vision stimulation；
The eye-tracking module is used for the tracking viewing when the three-dimensional stimulation display module shows 3D vision stimulation
The eye motion of the non-human primate of the 3D vision stimulation, and eye motion track is sent to the data integration
Module；
The Neural Signal Collecting module is used for the acquisition when the three-dimensional stimulation display module shows 3D vision stimulation
The biological neural signal of the non-human primate of the 3D vision stimulation is watched, and the biological neural signal is sent to
The data integration module；
The data integration module is used to believe 3D vision stimulation, the eye motion track with corresponding biological neural
Number integrated storage.
2. system according to claim 1, which is characterized in that the eye-tracking module is also used to transport eyes for described
Dynamic rail mark is sent to the three-dimensional stimulation control module；
The three-dimensional stimulation control module is also used to be determined according to the eye motion track when the viewing 3D vision stimulation
Non-human primate when watching the central region of the three-dimensional stimulation display module attentively, control the three-dimensional stimulation display module
Show the 3D vision stimulation.
3. system according to claim 2, which is characterized in that further include: award control module, for according to the three-dimensional
The control of control module is stimulated, provides food reward to watch the non-human primate of the 3D vision stimulation；
The three-dimensional stimulation control module is specifically used for determining the non-human primate note when watching the 3D vision stimulation
When depending on the three-dimensional central region for stimulating display module, according to logic of propositions, controls the three-dimensional stimulation display module and show
The 3D vision stimulation, and the eye motion track of the eye-tracking module tracks is obtained, if the eye motion track
Meet predetermined movement track rule, then controls the non-human primates that the award control module is the viewing 3D vision stimulation
Animal provides food reward.
4. system according to claim 3, which is characterized in that the three-dimensional stimulation display module includes that wear-type three-dimensional is aobvious
Show glasses, the eye-tracking module includes eye-tracking camera, and the eye-tracking camera is integrated in the wear-type
In Three-dimensional Display glasses, composition wear-type is visually equipped, and the wear-type visually equips and watches the 3D vision stimulation
Non-human primate matching.
5. system according to any one of claims 1 to 4, which is characterized in that the Neural Signal Collecting module, including mind
Through cell optical imagery submodule and/or neurotransmitter detection sub-module；
The nerve cell optical imagery submodule is used to obtain the non-human primate for watching the 3D vision stimulation
Cranial nerve cell functional imaging；
The neurotransmitter detection sub-module is used to detect the nerve for watching the non-human primate of the 3D vision stimulation
Mediator concentration.
6. a kind of non-human primate 3D vision stimulation test method characterized by comprising
3D vision stimulation is generated, and shows the 3D vision stimulation；
The eye motion of the non-human primate of the 3D vision stimulation is watched in tracking, obtains eye motion track；
Judge the non-human primate for watching the 3D vision stimulation whether to described three according to the eye motion track
It ties up visual stimulus and generates expected eye movement behavior；
The biological neural signal of the non-human primate of the 3D vision stimulation is watched in acquisition；
3D vision stimulation, the eye motion track are integrated into storage with corresponding biological neural signal.
7. according to the method described in claim 6, it is characterized in that, the display 3D vision stimulation, comprising:
According to the eye motion track, determine when in the non-human primate visual field of fixation for watching the 3D vision stimulation
When the heart, the 3D vision stimulation is shown.
8. determination is when viewing the method according to the description of claim 7 is characterized in that described according to the eye motion track
When the non-human primate visual field of fixation center of the 3D vision stimulation, the 3D vision stimulation is shown, comprising:
It determines when watching the non-human primate visual field of fixation center of the 3D vision stimulation, according to logic of propositions, shows
Show the 3D vision stimulation；
The eye motion of the non-human primate of 3D vision stimulation is watched in the tracking, obtain eye motion track it
Afterwards, the method also includes:
If the eye motion track meets predetermined movement track rule, for the inhuman spirit length for watching the 3D vision stimulation
Class animal provides food reward.
9. according to the described in any item methods of claim 6~8, which is characterized in that the 3D vision thorn is watched in the acquisition
The biological neural signal of sharp non-human primate, comprising:
The cranial nerve cell functional imaging for watching the non-human primate of the 3D vision stimulation is obtained, and/or detection is seen
See the concentration of neurotransmitters of the non-human primate of the 3D vision stimulation.
10. according to the described in any item methods of claim 6~8, which is characterized in that the method also includes:
The limb activity of the non-human primate of the 3D vision stimulation is watched in detection；
Include: with the integrated storage of corresponding biological neural signal by 3D vision stimulation, the eye motion track
3D vision stimulation, the eye motion track are integrated with corresponding biological neural signal and limb activity and deposited
Storage.
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