CN110507687A - 一种苍耳子二萜类化合物的制备方法及其组合物与应用 - Google Patents
一种苍耳子二萜类化合物的制备方法及其组合物与应用 Download PDFInfo
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- CN110507687A CN110507687A CN201910871921.8A CN201910871921A CN110507687A CN 110507687 A CN110507687 A CN 110507687A CN 201910871921 A CN201910871921 A CN 201910871921A CN 110507687 A CN110507687 A CN 110507687A
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
Description
有效成分提取量mg/g | |
实施例1 | 7.95 |
实施例2 | 8.03 |
实施例3 | 8.67 |
实施例4 | 8.73 |
实施例5 | 8.84 |
对比例1 | 8.01 |
对比例2 | 8.10 |
对比例3 | 8.19 |
对比例4 | 8.26 |
观察项 | 轻度 | 计分 | 中度 | 计分 | 重度 | 计分 |
鼻痒 | 轻碰数次 | 1 | 二者之间 | 2 | 四处摩擦 | 3 |
鼻涕 | 可见鼻涕少量 | 1 | 涕过中线 | 2 | 涕流满面 | 3 |
喷嚏 | 1-3次 | 1 | 4-10次 | 2 | >11次 | 3 |
粘膜厚度/mm | 粘膜腺体数目/个 | 粘膜杯状细胞数/个 | 淋巴小结数目/个 | |
空白组 | 0.182±0.24<sup>a</sup> | 7.72±1.21<sup>a</sup> | 5.36±1.36<sup>a</sup> | 2.03±0.72<sup>a</sup> |
模型组 | 0.412±0.12 | 18.03±2.15 | 14.12±2.59 | 7.31±2.68 |
实施例5 | 0.193±0.04<sup>b</sup> | 8.51±1.71<sup>b</sup> | 6.89±1.77<sup>b</sup> | 3.02±0.92<sup>b</sup> |
对比例1 | 0.235±0.04<sup>c</sup> | 9.58±1.12<sup>c</sup> | 7.81±1.89<sup>c</sup> | 4.49±1.48<sup>c</sup> |
对比例2 | 0.228±0.05<sup>c</sup> | 9.52±1.25<sup>c</sup> | 7.74±1.92<sup>c</sup> | 4.36±1.27<sup>c</sup> |
对比例3 | 0.223±0.08<sup>c</sup> | 9.47±1.21<sup>c</sup> | 7.67±2.05<sup>c</sup> | 4.02±0.83<sup>c</sup> |
对比例4 | 0.214±0.10<sup>c</sup> | 9.40±1.23<sup>c</sup> | 7.58±2.17<sup>c</sup> | 3.84±0.94<sup>c</sup> |
对比例5 | 0.218±0.09<sup>c</sup> | 9.48±1.08<sup>c</sup> | 7.62±2.28<sup>c</sup> | 3.96±1.34<sup>c</sup> |
对比例6 | 0.220±0.07<sup>c</sup> | 9.55±1.29<sup>c</sup> | 7.70±2.03<sup>c</sup> | 4.17±1.26<sup>c</sup> |
疗效显著/人 | 疗效一般/人 | 无效/人 | |
实施例5 | 13 | 2 | 0 |
对比例1 | 7 | 5 | 3 |
对比例2 | 8 | 3 | 4 |
对比例3 | 9 | 4 | 2 |
对比例4 | 10 | 3 | 2 |
对比例5 | 8 | 4 | 3 |
对比例6 | 9 | 2 | 4 |
Claims (10)
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CN113943211A (zh) * | 2021-09-08 | 2022-01-18 | 新疆维吾尔自治区中药民族药研究所 | 维吾尔药材中二萜及其制备方法和作为制备预防或/和治疗炎症的抗炎、抗菌药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1686254A (zh) * | 2005-03-28 | 2005-10-26 | 中国人民解放军第二军医大学 | 苍耳子总苷提取物用于制备抗炎性反应产品的用途 |
CN1687092A (zh) * | 2005-03-28 | 2005-10-26 | 中国人民解放军第二军医大学 | 苍耳子总苷提取物及其制备方法 |
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CN1686254A (zh) * | 2005-03-28 | 2005-10-26 | 中国人民解放军第二军医大学 | 苍耳子总苷提取物用于制备抗炎性反应产品的用途 |
CN1687092A (zh) * | 2005-03-28 | 2005-10-26 | 中国人民解放军第二军医大学 | 苍耳子总苷提取物及其制备方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113943211A (zh) * | 2021-09-08 | 2022-01-18 | 新疆维吾尔自治区中药民族药研究所 | 维吾尔药材中二萜及其制备方法和作为制备预防或/和治疗炎症的抗炎、抗菌药物中的应用 |
CN113943211B (zh) * | 2021-09-08 | 2023-08-29 | 新疆维吾尔自治区中药民族药研究所 | 维吾尔药材中二萜及其制备方法和作为制备预防或/和治疗炎症的抗炎、抗菌药物中的应用 |
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