CN110501488A - A kind of pallet apparatus of micro-fluidic sample-processing equipment - Google Patents
A kind of pallet apparatus of micro-fluidic sample-processing equipment Download PDFInfo
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- CN110501488A CN110501488A CN201910762383.9A CN201910762383A CN110501488A CN 110501488 A CN110501488 A CN 110501488A CN 201910762383 A CN201910762383 A CN 201910762383A CN 110501488 A CN110501488 A CN 110501488A
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- 238000012545 processing Methods 0.000 title claims abstract description 36
- 238000009434 installation Methods 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 41
- 239000002699 waste material Substances 0.000 claims description 37
- 238000011084 recovery Methods 0.000 claims description 32
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 230000007246 mechanism Effects 0.000 claims description 11
- 238000003780 insertion Methods 0.000 claims description 9
- 230000037431 insertion Effects 0.000 claims description 9
- 238000004064 recycling Methods 0.000 claims description 6
- 238000005213 imbibition Methods 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 3
- 241000150100 Margo Species 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 description 60
- 239000012530 fluid Substances 0.000 description 29
- 239000000306 component Substances 0.000 description 14
- 230000003139 buffering effect Effects 0.000 description 9
- 238000004043 dyeing Methods 0.000 description 9
- 230000003028 elevating effect Effects 0.000 description 9
- 230000001960 triggered effect Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 230000007257 malfunction Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 239000010808 liquid waste Substances 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000005622 photoelectricity Effects 0.000 description 4
- 230000001360 synchronised effect Effects 0.000 description 4
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 240000009087 Crescentia cujete Species 0.000 description 1
- 235000005983 Crescentia cujete Nutrition 0.000 description 1
- 235000009797 Lagenaria vulgaris Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Fluid Mechanics (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of pallet apparatus of micro-fluidic sample-processing equipment, including bottom plate and the upper plate being fixedly installed on the bottom plate, the upper plate includes left and right extension and multiple front and back extensions extended forward from the left and right extension, multiple front and back extensions side by side and are positioned apart from left-right direction, are respectively formed with the mounting groove for being used to install kit that a front side and upside open between two front and back extensions of arbitrary neighborhood.The pallet apparatus can cooperate micro-fluidic sample-processing equipment to use, to realize that structure setting is compact, easy for installation to the automatic processing of micro-fluidic sample.
Description
Technical field
The invention belongs to technical field of biological, are related to a kind of pallet apparatus of micro-fluidic sample-processing equipment.
Background technique
Microflow control technique is the sorting analysis method of a kind of important cell or biomolecule, such as capture circulating tumor is thin
Born of the same parents (CTC) have the advantages that easy to operate, required amount of antibody is few.Micro-fluidic chip is the core component of microflow control technique, micro-
Fluidic chip has fluid channel and is attached with specific antibody, and the target cell or biomolecule for that will flow through its sample are cut
Stay capture.These captured cells or biomolecule generally require to be used to analyze into excessively a series of post-processing, such as clear
It washes, primary antibody or two process resistant, dyeing etc..It is manually carried out currently, these processing pass through mostly, cumbersome and inconvenient, efficiency
Lower, the degree of automation is lower.
Summary of the invention
The object of the present invention is to provide a kind of pallet apparatus of micro-fluidic sample-processing equipment.
In order to achieve the above objectives, the technical solution adopted by the present invention are as follows:
A kind of pallet apparatus of micro-fluidic sample-processing equipment including bottom plate and is fixedly installed on upper on the bottom plate
Plate, the upper plate include left and right extension and multiple front and back extensions extended forward from the left and right extension, multiple described
Front and back extension side by side and is positioned apart from left-right direction, is respectively formed with one between two front and back extensions of arbitrary neighborhood
The mounting groove for being used to install kit that front side and upside open.
Preferably, the left side being used for for kit extended along the longitudinal direction is respectively arranged on each front and back extension
Edge or the slot of margo dexter insertion, the slot on two neighboring front and back extension are oppositely arranged.
Preferably, the upper plate is equipped with the positioning mechanism for being positioned to the kit.
It is highly preferred that the positioning mechanism includes the positioning protrusion upwardly extended being formed on the upper plate.
Preferably, the pallet apparatus further includes baffle, and the rear end of the mounting groove is located at the underface of the baffle.
Preferably, kit is installed, the kit includes box body, is opened up on the box body useful in the mounting groove
Waste collection hole and one or more storage reagents in chip fixture insertion and storage waste liquid for being fixed with micro-fluidic chip
Reagent wells.
It is highly preferred that being additionally provided with the chip recovery holes for recycling the chip fixture, the pallet on the box body
Device further includes baffle, and the part of the chip recovery holes is located at the underface of the baffle.
Further, the chip recovery holes are the long hole or kidney slot extended along the longitudinal direction.
Further, when the chip fixture is located at the rear end of the chip recovery holes, the baffle is in institute
State the top of chip fixture.
Further, the chip fixture includes that ontology and the diversion pipe for imbibition and drain, the ontology have
For installing the inner cavity of micro-fluidic chip, the diversion pipe is extended downwardly from the ontology and is connected to the inner cavity, and described
The interconnecting piece for mechanical arm connection is formed on body；It is described when the chip fixture is located at the rear end of the chip recovery holes
Baffle is in the top of the ontology.
The present invention uses above scheme, has the advantages that compared with prior art
Pallet apparatus of the invention can cooperate micro-fluidic sample-processing equipment to use, with realize to micro-fluidic sample from
Dynamicization processing installs kit by the open mounting groove in front side and upside, the integrated chip fixture and various on kit
Processing is practical, the functions such as cell or biomolecule capture, fixation, cleaning, antibody incubation, dyeing is integrated with, so as to cooperate
A series of above-mentioned processing of the micro-fluidic sample-processing equipment to micro-fluidic sample, structure setting is compact, easy for installation.
Detailed description of the invention
It, below will be to attached drawing needed in embodiment description in order to illustrate more clearly of technical solution of the present invention
It is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, general for this field
For logical technical staff, without creative efforts, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is a kind of stereoscopic schematic diagram of micro-fluidic sample-processing equipment；
Fig. 2 a is a kind of schematic diagram of internal structure of micro-fluidic sample-processing equipment, and part of shell is not shown；
Fig. 2 b is the partial enlarged view in Fig. 2 a at A；
Fig. 3 is a kind of top view of micro-fluidic sample-processing equipment, and part of shell is not shown；
Fig. 4 is a kind of main view of micro-fluidic sample-processing equipment, and part of shell is not shown；
Fig. 5,6,7 are a kind of stereoscopic schematic diagram of pallet apparatus of embodiment respectively, wherein the part upper plate and baffle of Fig. 7
It is not shown；
Fig. 8 is the stereoscopic schematic diagram of mechanical arm；
Fig. 9 is the schematic diagram of single mechanical arm；
Figure 10 is the schematic diagram of single mechanical arm, and wherein shell is not shown；
Figure 11 is the partial sectional view of mechanical arm, lifting device and translating device；
Figure 12 is the cross-sectional view of negative-pressure liquid suction device.
In above-mentioned attached drawing,
1, rack；10, shell；101, door；
2, kit；20, box body；21, waste collection hole；22, fixed fluid apertures；23, fluid apertures is buffered；24, the first primary antibody hole；
25, the second primary antibody hole；26, secondary antibody hole；27, fluid apertures is dyed；28, chip recovery holes；
3, chip fixture；30, ontology；31, diversion pipe；32, barrel；
4, pallet apparatus；40, mounting groove；41, bottom plate；42, upper plate；421, left and right extension；422, front and back extension；
423, slot；424, positioning protrusion；43, baffle；
5, mechanical arm；50, shell；51, pipette tips；511, the first flange；512, the second flange；52, elevating lever；521 rack gears
Portion；53, connector；
6, negative-pressure liquid suction device；61, vacuum motor；611, push plate；62, piston；63, piston shell；631, air chamber；64,
Photoelectric detection switch；65, baffle；
7, lifting device；71, lift shaft；72, gear；721, square hole；73, lifting motor；
8, translating device；81, mounting plate；811, guide rail；82, x is to motor；83, lead screw；84, y is to motor；85, synchronous belt
Transmission mechanism；86, sliding rail；87, sliding block；
9, fault detection means；91, the first photoelectric detection switch；92, first flap；93, the second photoelectric detection switch；
94, second flap；95, third photoelectric detection switch；96, malfunction indicator lamp.
Specific embodiment
The preferred embodiments of the present invention will be described in detail with reference to the accompanying drawing, so that advantages and features of the invention energy
It is easier to be understood by the person skilled in the art.It should be noted that the explanation for these embodiments is used to help
Understand the present invention, but and does not constitute a limitation of the invention.
Fig. 1 to Figure 11 shows a kind of micro-fluidic sample-processing equipment, and which employs pallet apparatus provided in this embodiment.
Referring to figs. 1 to shown in Figure 11, micro-fluidic sample-processing equipment mainly include pallet apparatus 4, mechanical arm 5, negative-pressure liquid suction device 6,
Lifting device 7 and translating device 8, pallet apparatus 4, mechanical arm 5, negative-pressure liquid suction device 6 and translating device 8 are arranged at the miniflow
In the rack 1 for controlling sample-processing equipment, 1 periphery of rack is covered with shell 10, and above-mentioned each device is enclosed in shell 10.Its
In, pallet apparatus 4 is for accommodating reagent and being equipped with the chip fixture 3 of micro-fluidic chip；Mechanical arm 5 has for loading chip
Pipette tips 51 in fixture 3 offer the airflow channel for being connected to 3 inner cavity of chip fixture in pipette tips 51；Negative-pressure liquid suction device 6 is used
Air pressure is provided in the airflow channel for pipette tips 51；Lifting device 7 is for driving the lifting of pipette tips 51 to load chip fixture 3 or make core
The insertion of plate clamp 3 is detached from reagent；Translating device 8 is for driving pipette tips 51 to be moved to 3 top of chip fixture or being moved to reagent
Top.Pallet apparatus 4 is located at the lower section of mechanical arm 5, and mechanical arm 5 is set on translating device 8 and connects with lifting device 7.Tool
Body, it include one or more kits 2 on pallet apparatus 4, storage has chip fixture 3 in kit 2, and micro-fluidic chip is installed
It is in chip fixture 3 and fixed by chip fixture 3.As shown in Figure 1, offering door 101 on shell 10, which can be upper and lower
The setting of sliding, the setting of 101 face pallet apparatus 4 of door, after door 101 slides upwards, pallet apparatus 4 exposes, can be easily
Installation or replacement kit 2.
In the present embodiment, pallet apparatus 4 has multiple kits 2 being set side by side in left-right direction (as shown in figure 3, support
Primary mountable four kits 2 in disk device 4).Referring to Figure 5, which includes box body 20, is opened up on box body 20
Have for for chip fixture 3 be inserted into and for store waste liquid waste collection hole 21, one or more storage reagents reagent wells with
And the chip recovery holes 28 for recycling chip fixture 3.Reagent wells specifically include the fixation fluid apertures 22 of storage fixer, storage
The buffering fluid apertures 23 of buffer, the primary antibody hole for storing primary antibody, the secondary antibody hole 26 for storing secondary antibody and the dyeing fluid apertures for storing dyeing liquor
27.Wherein, primary antibody hole specifically includes the second primary antibody hole 25 of the second primary antibody of the first primary antibody hole 24 and storage of the first primary antibody of storage.
Waste collection hole 21 and chip recovery holes 28 are respectively the stepped hole that top aperture is greater than lower part aperture, to cooperate chip fixture 3
Shape, convenient for chip fixture 3 be inserted into.Chip recovery holes 28 are long hole or kidney slot, the length direction of the chip recovery holes 28
It is consistent with the length direction of box body 20.In the kit 21, reagent, chip fixture 3 are disposable in kit 21；It can
Handle multiple steps such as liquid relief, sorting, waste liquid；Inside operation, pollution risk are small.Moreover, 21 whole design of kit, and reagent
Reagent is separately stored in hole, no mixing, is adapted to the difference of different step using concentration, is adapted to store for a long time.Reagent storage
Section and kit 21 are an overall structure, keep reagent storage more stable, and operation when is more firm.It is useless in kit 21
Liquid collects the installation position and liquid waste processing position that hole 21 is both chip fixture 3, that is, saves 21 space of kit, also do not need to grasp
In addition work person prepares container collection waste liquid.
Waste collection hole 21 and chip recovery holes 28 are located on former and later two ends of box body 20, fixed fluid apertures 22,
Buffering fluid apertures 23 and primary antibody hole are set in turn between waste collection hole 21 and chip recovery holes 28, secondary antibody hole 26 and dyeing fluid apertures
27 or so are juxtaposed between primary antibody hole and chip recovery holes 28.That is, waste collection hole 21, fixed fluid apertures 22, slow
Flushing hole 23, primary antibody hole, secondary antibody hole 26 or dyeing fluid apertures 27, chip recovery holes 28 are along length direction (the i.e. front and back of box body 20
To) be sequentially arranged at intervals.In the present embodiment, waste collection hole 21 is for storing sample (such as blood being discharged from micro-fluidic chip
The body fluid such as liquid, urine, tissue fluid, spinal fluid), reagent etc.；Storage has fixer in fixed fluid apertures 22；It is stored in buffering fluid apertures 23
There is PBS buffer solution；Storage has primary antibody A in first primary antibody hole 24, and storage has primary antibody B in the second primary antibody hole 25；It is deposited in secondary antibody hole 26
It is placed with secondary antibody；Storage has DAPI dyeing liquor in dyeing fluid apertures 27.
Referring to shown in Fig. 8, chip fixture 3 is micro-fluidic including ontology 30 and with the diversion pipe 31 for imbibition and drain
Chip is mounted in the inner cavity of ontology 30, and diversion pipe 31 is extended downwardly from ontology 30 and is connected to inner cavity.It is formed on ontology 30
For the interconnecting piece of mechanical arm connection, specific in the present embodiment, the top of ontology 30 is formed with the lower end insertion for mechanical arm 5
Barrel 32.The hollow setting of barrel 32, and be interconnected with the inner cavity of ontology 30.30 energy of ontology of the chip fixture 3
Sample is enough stored, the diversion pipe 31 of lower part can be discharged waste liquid and draw reagent, lead to the waste liquid for flowing through micro-fluidic chip
Stream and absorption reagent flow it through micro-fluidic chip and are incubated for or are cleaned, and can facilitate in micro-fluidic chip capture sample
Target cell or biomolecule simultaneously easily can draw or be discharged reagent.
The micro-fluidic sample-processing equipment has waste collection state, chip recycling state and liquid relief state.When micro-fluidic
In waste collection state, chip fixture 3 is inserted in the waste collection hole 21 of kit 21 sample-processing equipment, ontology 30
Positioned at the top of stepped hole, diversion pipe 31 is then inserted into the lower part of stepped hole, as locating for the chip fixture 3 of the leftmost side into Fig. 7 Fig. 5
Position.When micro-fluidic sample-processing equipment is when chip recycles state, chip fixture 3 is inserted in the chip recycling of kit 21
In hole 28, ontology 30 is located at the top of stepped hole, and diversion pipe 31 is then inserted into the lower part of stepped hole, such as centre of the Fig. 5 into Fig. 7
The location of two chip fixtures 3.When micro-fluidic sample-processing equipment is in liquid relief state, chip fixture 3 is detached from waste liquid and receives
Collect hole 21, chip fixture 3 is located in one of the top of reagent wells, and diversion pipe 31 is inserted into reagent wells.
Specifically, in conjunction with shown in Fig. 5 to Fig. 7, pallet apparatus 4 is equipped with multiple mounting grooves being set side by side in left-right direction
40, a kit 2 is inserted in each mounting groove 40.In the present embodiment, pallet apparatus 4 includes being fixed in rack 1
Bottom plate 41 and the upper plate 42 that is fixedly installed on bottom plate 41, upper plate 42 include left and right extension 421 and multiple extend from left and right
The front and back extension 422 that portion 421 extends forward, multiple front and back extensions 422 side by side and are positioned apart from left-right direction, arbitrarily
The mounting groove 40 that front side and upside open is respectively formed between two neighboring front and back extension 422.Each front and back extension
The slot 423 extended along the longitudinal direction is respectively arranged on 422, the slot 423 on two neighboring front and back extension 422 is opposite to be set
It sets, the left and right sides edge of kit 2 is inserted in corresponding two slots 423.Upper plate 42 is specifically by upper layer and lower layer board stacking shape
At the slot 423 is formed between upper layer and lower layer plate.
Upper plate 42 is equipped with the positioning mechanism for being positioned to kit 2.In the present embodiment, as shown in fig. 7, positioning
Mechanism includes the positioning protrusion 424 upwardly extended being formed on upper plate 42, and kit is equipped with recess portion downwards.Work as examination
After agent box is installed in place, positioning protrusion 424 is inserted into the recess portion of kit, and the slot 423 of two sides is cooperated to be fixed on kit
In mounting groove 40, kit is prevented to shake.During installation, the left and right sides edge of kit 2 is inserted into the slot 423 of two sides,
The front side of its self installation slot 40 is pushed into, until snapping on positioning protrusion 424.
Further, pallet apparatus 4 further includes baffle 43, and the part of chip recovery holes is located at the underface of baffle 43.Gear
Plate 43 is specifically fixedly installed in bottom plate 41 or rack 1, and baffle 43 is located at reagent below the top and partial occlusion of upper plate 42
The chip recovery holes 28 of box, for stopping chip fixture 3 to be detached from chip recovery holes 28.When micro-fluidic sample-processing equipment is in waste liquid
When collection status, chip fixture 3 can be slidably inserted in chip recovery holes 28 along the longitudinal direction.In recycling micro-fluidic chip
When, chip fixture 3 is downwardly into chip recovery holes 28 (such as Fig. 5 second core in left side into Fig. 7 from 28 front end of chip recovery holes
The location of plate clamp 3), then (such as Fig. 5 left side third core into Fig. 7 is moved at its rear end along chip recovery holes 28
The location of plate clamp 3), it is limited in chip recovery holes 28 by baffle 43, so that chip fixture 3 be unloaded from mechanical arm 5
Under.
The quantity of mechanical arm 5 is multiple, four as shown in Figure 8.Multiple mechanical arms 5 are set side by side in left-right direction, and
It is corresponded respectively with multiple kits 2 of lower section.In conjunction with shown in Fig. 8 to Figure 11, each mechanical arm 5 respectively include shell 50,
It the elevating lever 52 that can be movably arranged on shell 50 along the vertical direction, the pipette tips 51 being set on 52 lower end of elevating lever and sets
It is placed in the connector 53 of 52 upper end of elevating lever.Connector 53 is used to be connected to the connector 53 of negative-pressure liquid suction device 6, and elevating lever 52 is hollow to be set
It sets, is that pipette tips 51 provide the air pressure for imbibition or drain by negative-pressure liquid suction device 6.
As shown in figure 9, pipette tips 51 include ontology, from the first flange 511 outwardly extended of the lower part of ontology and
Second flange 512, the first flange 511 is located at top a distance of the second flange 512, and the outer diameter of the first flange 511 is small
In the outer diameter of the second flange 512.The lower end of pipette tips 51 is substantially in calabash shaped, when it is inserted into the barrel 32 of chip fixture 3,
It connects relatively firm, chip fixture 3 is avoided to fall from pipette tips 51.
In conjunction with shown in Fig. 3, Fig. 4, Figure 10 and Figure 11, lifting device 7 includes by the lifting of lifting drive mechanism driving rotation
Rotating assembly is formed with one or more circle teeth on the outer circumference surface of lift shaft component, and elevating lever 52, which has, to be vertically extended
Tooth-strip part 521, the tooth intermeshing on tooth-strip part 521 and lift shaft component.Specifically, above-mentioned lifting drive mechanism tool
Body is lifting motor 73, and lift shaft component includes by the lift shaft 71 of the driving rotation of lifting motor 73 and with lift shaft 71
One or more gears 72 of rotation offer polygonal hole on gear 72, and lift shaft 71 is inserted in polygonal hole and can
72 OQ t shaft 71 of gear is allowed to move horizontally.Gear 72 is fixed in shell 50.Above-mentioned 72 quantity of gear and
The quantity of mechanical arm 5 is corresponding, i.e., is fixedly installed a gear 72 in the shell 50 of each mechanical arm 5.As shown in figure 11,
Above-mentioned polygonal hole is specially square hole 721, and the section of above-mentioned lift shaft 71 corresponds to rectangular, and lift shaft 71 is along a left side
Right direction extends and sequentially passes through the square hole 721 of the gear 72 in multiple mechanical arms 5, can be with when lift shaft 71 rotates
Band moving gear 72 rotates, and drives elevating lever 52 to move up and down under the cooperation of rack-and-pinion.At the same time, when mechanical arm 5 by
When the leftward or rightward power that translating device 8 applies, and gear 72 can allow for slide on lift shaft 71, thus mechanical arm
5 can move in left-right direction under the drive of translating device 8.
In conjunction with shown in Fig. 3, Fig. 4 and Figure 11, translating device 8 include x for driving mechanical arm 5 to move in left-right direction to
Component and y for driving mechanical arm 5 to move along the longitudinal direction are to component, wherein mechanical arm 5 is set to x on component, x to
Component is set to y on component, and y is set in rack 1 to component.Specifically, x to component include mounting plate 81 and along right and left
To the lead screw 83 of extension, lead screw 83 can be rotatably arranged on mounting plate 81 around self-axis line, and lead screw 83 is arranged in mechanical arm 5
Middle incorporating mill tool arm 5 is connected through a screw thread.The guide rail 811 extended in left-right direction, each machinery are fixedly installed on mounting plate 81
Arm 5 can be slidingly arranged in left-right direction on guide rail 811, and specially the shell 50 of mechanical arm 5 and guide rail 811 are slidably matched ground
Connection.X to component further include x for driving lead screw 83 to rotate to motor 82.Lead screw 83 and lift shaft 71 are arranged in parallel, and
Lead screw 83 is located at the top of lift shaft 71, and the top of lead screw 83 from mechanical arm 5 passes through, and lift shaft 71 is under mechanical arm 5
Portion passes through.Y to component include the sliding rail 86 extended along the longitudinal direction and the sliding block 87 being slidably disposed on sliding rail 86, sliding rail
86 are fixedly installed in rack 1, and x is fixedly installed on sliding block 87 to the mounting plate 81 of component.Y to component further include y to motor
84 and synchronous belt drive mechanism 85 from y to motor 84 that driven from, synchronous belt drive mechanism 85 and sliding block 87 connect.
In conjunction with shown in Fig. 2 b and Figure 12, negative-pressure liquid suction device 6 includes by 61 drives edge straight reciprocating of vacuum motor
Piston 62 and the piston shell 63 for being provided with air chamber 631, piston shell 63 are fixed on mounting plate 81, and piston 62 is movably
It is plugged in the air chamber 631 of piston shell 63.Negative-pressure liquid suction device 6 further includes gas-guide tube (not shown), and the one of gas-guide tube
End is fixedly connected on piston shell 63 and is interconnected with air chamber 631, and the other end of gas-guide tube is fixedly connected on mechanical arm
5.In the present embodiment, the quantity of piston 62, air chamber 631 and gas-guide tube be it is multiple, it is corresponding with the quantity of mechanical arm 5 respectively.
That is, offering multiple mutually independent air chambers 631 in piston shell 63, in each air chamber 631 respectively slidably
Be provided with a piston 62, when vacuum motor 61 with piston 62 move back and forth when, air chamber 631 and pass through gas-guide tube and gas
The air pressure in pipette tips 51 that chamber 631 is connected to changes therewith, so as to draw reagent or discharge reagent.The negative-pressure liquid suction device 6
Pressure control is generated using 62 principle of piston under air-tight state and draws or be discharged liquid, and piston 62 is transported backward when head is under liquid level
The raw negative pressure of movable property achievees the purpose that draw liquid, on the contrary when in pipette tips 51 there are piston 62 when liquid travel forward generate positive pressure from
And liquid is discharged.62 front end of piston is provided with rubber pad, increases airtightness by rubber pad.
The negative-pressure liquid suction device 6 further includes the piston testing agency for monitoring the displacement of piston 62.In the present embodiment, such as scheme
Shown in 2b, piston testing agency includes the photoelectric detection switch 64 being fixedly installed in piston shell 63 and with 62 synchronizing moving of piston
Baffle 65, when piston 62 is moved to maximum setting displacement, baffle 65 is moved at photoelectric detection switch position 64, photoelectricity inspection
Switch 64 is surveyed to be triggered and issue detection signal.The photoelectric detection switch 64 and controller of piston testing agency pass through conducting wire electrical property
Connection, vacuum motor 61 and the controller are electrically connected by conducting wire, are issued after the photoelectric detection switch 64 is triggered
Signal is detected, controller receives the detection signal and issues control signal out of service to vacuum motor 61, vacuum motor
61 is out of service in response to the control signal, and piston 62 stops movement.Specifically, vacuum motor 61 is mounted on piston shell 63
On, the motor shaft of vacuum motor 61 and a push plate 611 connect and drive the push plate 611 along straight reciprocating, multiple pistons 62
It is fixed in the push plate 611, synchronizing moving is driven by the push plate 611, the baffle 65 is fixed at push plate 611
On.
The micro-fluidic sample-processing equipment further includes fault detection means 9.Fault detection means 9 includes at least one detection
Unit, detection unit include a pair of spaced photoelectric detection switch and a baffle mobile with pipette tips 51, baffle setting
Between a pair of of photoelectric detection switch.Baffle is specially metal baffle.Specific in the present embodiment, the quantity of detection unit is three
It is a, respectively first detection unit, second detection unit and third detection unit.First detection unit is for detecting 51 edge of pipette tips
The moving distance of up and down direction, for second detection unit for detecting the moving distance of pipette tips 51 in left-right direction, third detection is single
Member is for detecting the moving distance of pipette tips 51 along the longitudinal direction.As shown in figure 8, first detection unit includes a pair of first photoelectricity inspection
Switch 91 and a first flap 92 are surveyed, a pair of first photoelectric detection switch 91 is arranged close to mechanical arm 5, is specifically fixed at
On the shell 50 of one of mechanical arm 5, the two is arranged along the vertical direction and has the first interval, and the first interval is greater than elevating lever
The 52 maximum setting strokes moved along the vertical direction, first flap 92 are fixedly connected on elevating lever 52 and are located at a pair of first photoelectricity
Between detection switch 91.As shown in figure 3, second detection unit includes a pair of second photoelectric detection switch 93 and a second flap
94, a pair of second photoelectric detection switch 93 is arranged close to mechanical arm 5, is specifically fixed at the close mechanical arm 5 of mounting plate 81
Position at, the two is in left-right direction arranged and has the second interval, and the second interval is greater than mechanical arm 5 and moves in left-right direction
Maximum setting stroke, second flap 94 are fixedly connected on one of mechanical arm 5 (the specially shell 50 of mechanical arm 5) and are located at
Between a pair of second photoelectric detection switch 93.In conjunction with shown in Fig. 2 b and Fig. 3, third detection unit includes a pair of of third Photoelectric Detection
Switch 95 and a third baffle (not shown), a pair of of third photoelectric detection switch 95 are fixed at the close of rack 1
At the position of sliding block 87, it is specifically set to the side of sliding rail 86, the two is arranged along the longitudinal direction and has third interval, between third
Stroke is set every being greater than the maximum that mechanical arm 5 moves along the longitudinal direction, third baffle is fixedly connected on sliding block 87 and is located at a pair
Between third photoelectric detection switch 95.
The fault detection means 9 further includes controller, and controller and each photoelectric detection switch are electrically connected, and controller is used for
Mechanical arm 5 is controlled after any one photoelectric detection switch is triggered stops movement.Fault detection means 9 further includes indicating fault
Lamp 96, controller and malfunction indicator lamp 96 are electrically connected, and controller is also used to after any one photoelectric detection switch is triggered
It controls malfunction indicator lamp 96 and switches light color.Specifically, controller and a pair of first photoelectric detection switch 91, a pair of second light
Electro-detection switch 93 and a pair of of third photoelectric detection switch 95 are respectively by conducting wire electric connection, and controller is also and lifting motor
73, x is electrically connected by conducting wire respectively to motor 82 and y to motor 84.It is set when mechanical arm 5 moves out maximum along the vertical direction
Positioning moves, and first flap 92 is moved at a certain first photoelectric detection switch 91, and the first photoelectric detection switch 91 is triggered and is sent out
Be out of order signal, and controller issues stopping to motor 84 to motor 82 and y and transport after receiving fault-signal to lifting motor 73, x
Capable first control signal, while controller also issues the second control signal of switching instruction color to malfunction indicator lamp 96, rings
Should be out of service to motor 82 and y to motor 84 in first control signal lifting motor 73, x, in response to second control signal, therefore
The color for hindering indicator light 96 becomes red from green.As shown in Figure 1, malfunction indicator lamp 96 is specifically located on shell 10, including
The LED light of strip；When micro-fluidic sample-processing equipment operates normally, the color of malfunction indicator lamp 96 is shown in green；When
Mechanical arm 5 in either direction when moving out maximum setting stroke, then judge micro-fluidic sample-processing equipment failure, Ge Ge electricity
Machine is out of service, and mechanical arm 5 stops movement, and simultaneous faults indicator light 96 is shown in red.The error running of mechanical arm 5 is avoided to damage
Bad sample and machine itself.
The testing principle of the photoelectric detection switch used in the present embodiment are as follows: when baffle is moved at Photoelectric Detection position
Afterwards, the detection light of photoelectric detection switch is blocked, so that photoelectric detection switch be made to be triggered.Photoelectric detection switch is typically
Infrared detection switch, i.e. by infrared detection switch triggering after baffle blocks the infrared ray that infrared detection switch issues.
In other embodiments, fault detection means 9 further includes audible alarm unit, controller and audible alarm dress
Electric connection is set, controller, which is also used to control audible alarm unit after any one photoelectric detection switch is triggered, issues warning
Sound.
In the fault detection means 9, between 5 normal operation range of mechanical arm and photoelectric detection switch there are also it is a bit of away from
From significantly reducing probability of the photoelectric detection switch by erroneous trigger.Once mechanical arm 5 breaks down, baffle reaches photoelectricity
Detection switch position, mechanical arm 5 will stop motion immediately, effectively increase the safety of machine.It is easy to operate, fault reaction
Intuitively.
The course of work of the micro-fluidic sample-processing equipment are as follows:
1, kit 2 is fitted into the mounting groove 40 of pallet apparatus 4, translating device 8, which drives mechanical arm 5 to move horizontally, to be made respectively
Pipette tips 51 are in the surface of corresponding chip fixture 3, and lifting device 7, which drives mechanical arm 5 to go up and down, inserts the lower end of pipette tips 51
Enter in the barrel 32 of chip fixture 3, chip fixture 3 is loaded in pipette tips 51；At this point, chip fixture 3 is initially located at waste liquid
It collects in hole 21, sample (body fluid, such as blood, urine, tissue fluid, spinal fluid etc.) is stored in the upper section of chip fixture 3, manipulator
It is mobile that entire chip fixture 3 can be carried after arm insertion barrel 32, and in insertion, negative-pressure liquid suction device 6 provides positive pressure, by sample
It flows through micro-fluidic chip in inner cavity in this push-in chip fixture 3, carries out cell capture, waste liquid passes through after micro-fluidic chip from core
The lower end diversion pipe 31 of plate clamp 3 flows out, and stays in waste collection hole 21, waste liquid involved in subsequent operation is all recovered to useless
Liquid is collected in hole 21.
2, lifting device 7 drives mechanical arm to move up, by the whole removal waste collection hole 21 of chip fixture 3；Translating device 8
Y acted to motor 84, make mechanical arm 5 that chip fixture 3 be driven to be moved to the top of fixed fluid apertures 22；Lifting device 7 is run, and is made
Mechanical arm 5 drives chip fixture 3 to move down, and diversion pipe 31 is inserted into fixed fluid apertures 22, negative-pressure liquid suction device 6, which provides negative pressure, to be made to lead
Flow tube 31 draws the fixer in fixed fluid apertures 22, and fixer passes through chip, the cell captured on fixed chip from bottom to up；It is flat
The y of telephone-moving structure is acted to motor 84, and mechanical arm 5 is moved back to 21 top of waste collection hole, and negative-pressure liquid suction device 6 provides positive pressure and will fix
Liquid drains into waste collection hole 21, and liquid waste processing is the same as herein in later step.
3, mechanical arm 5 controls the top that chip fixture 3 is moved to buffering fluid apertures 23, and diversion pipe 31 is inserted into buffering fluid apertures
In 23, PBS buffer solution is drawn, cleans chip, mechanical arm 5 is moved back to 21 top of waste collection hole, liquid waste processing to waste collection hole
21, it is repeated 2 times.
4, mechanical arm 5 controls the top that chip fixture 3 successively moves on to the first primary antibody hole 24, and diversion pipe 31 is inserted into the first primary antibody
Primary antibody A is sucked in hole 24, chip is incubated for primary antibody A 60 minutes, after waste liquid is discharged in waste collection hole 21, returns to buffering fluid apertures
It at 23, cleans 2 times, moves on at the second primary antibody hole 25, be incubated for primary antibody B 60 minutes, after waste liquid is discharged in waste collection hole 21, return
It at buffering fluid apertures 23, cleans 2 times, moves on to secondary antibody hole 26, be incubated for secondary antibody 60 minutes, after waste liquid is discharged in waste collection hole 21,
It returns at buffering fluid apertures 23, cleans 2 times, move on to dyeing fluid apertures 27, DAPI is dyed 5 minutes, and waste liquid is discharged in waste collection hole 21
Afterwards, it returns at buffering fluid apertures 23, cleans 2 times.
5, translating device 8 acts, and makes mechanical arm that chip fixture 3 be driven to move on at the front end of chip recovery holes 28；Lifting
Device 7 acts, and mechanical arm 5 drives chip fixture 3 to move down in the front end of insertion chip recovery holes；The y of translating device 8 is to motor 84
Operation makes the drive chip fixture 3 of mechanical arm 5 be moved to the rear end of chip recovery holes in chip recovery holes, at this time chip fixture 3
Part be located at the underface of baffle 43；Lifting device 7 acts, and mechanical arm 5 moves up, and chip fixture 3 is then by baffle 43
Blocking stays in chip recovery holes, realizes the disengaging of chip fixture 3 and pipette tips 51.
Above-mentioned micro-fluidic sample-processing equipment is integrated with cell or biomolecule capture, fixation, cleaning, antibody incubation, dye
A series of functions such as color, the automatic above-mentioned processing realized to micro-fluidic sample, reduce manpower intervention, and the degree of automation is higher,
Improve treatment effeciency；Operation can also be synchronized to multiple chip fixtures 3 simultaneously, be convenient for parallel test, and into one
Step improves treatment effeciency；In addition, structure setting is compact, and it is rationally distributed, reduce the occupied space of equipment.
The above embodiments merely illustrate the technical concept and features of the present invention, is a kind of preferred embodiment, and purpose exists
It cans understand the content of the present invention and implement it accordingly in person skilled in the art, protection of the invention can not be limited with this
Range.Equivalent transformation or modification made by all principles according to the present invention, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of pallet apparatus of micro-fluidic sample-processing equipment, it is characterised in that: including bottom plate and be fixedly installed on the bottom
Upper plate on plate, the upper plate include left and right extension and multiple front and back extensions extended forward from the left and right extension,
Multiple front and back extensions side by side and are positioned apart from left-right direction, distinguish shape between two front and back extensions of arbitrary neighborhood
The mounting groove for being used to install kit that Cheng Youyi front side and upside open.
2. pallet apparatus according to claim 1, it is characterised in that: be respectively arranged on each front and back extension along preceding
What rear direction extended is used for the slot of left border or the margo dexter insertion for kit, described on two neighboring front and back extension
Slot is oppositely arranged.
3. pallet apparatus according to claim 1, it is characterised in that: the upper plate be equipped with for the kit into
The positioning mechanism of row positioning.
4. pallet apparatus according to claim 3, it is characterised in that: the positioning mechanism includes being formed on the upper plate
The positioning protrusion upwardly extended.
5. pallet apparatus according to claim 1, it is characterised in that: the pallet apparatus further includes baffle, the installation
The rear end of slot is located at the underface of the baffle.
6. pallet apparatus according to claim 1, it is characterised in that: be equipped with kit, the examination in the mounting groove
Agent box includes box body, is offered on the box body for the chip fixture insertion for being fixed with micro-fluidic chip and stores waste liquid
The reagent wells in waste collection hole and one or more storage reagents.
7. pallet apparatus according to claim 6, it is characterised in that: be additionally provided on the box body for by the chip gripper
Have the chip recovery holes of recycling, the pallet apparatus further includes baffle, and the part of the chip recovery holes is located at the baffle
Underface.
8. pallet apparatus according to claim 7, it is characterised in that: the chip recovery holes extend along the longitudinal direction
Long hole or kidney slot.
9. pallet apparatus according to claim 8, it is characterised in that: the chip fixture is located at the chip recovery holes
When rear end, the baffle is in the top of the chip fixture.
10. pallet apparatus according to claim 9, it is characterised in that: the chip fixture includes ontology and for imbibition
With the diversion pipe of drain, the ontology has the inner cavity for installing micro-fluidic chip, and the diversion pipe is downward from the ontology
Extend and be connected to the inner cavity, the interconnecting piece for mechanical arm connection is formed on the ontology；The chip fixture is located at institute
When stating the rear end of chip recovery holes, the baffle is in the top of the ontology.
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| CN201910762383.9A CN110501488B (en) | 2019-08-19 | 2019-08-19 | Tray device of microfluidic sample processing equipment |
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| CN201910762383.9A CN110501488B (en) | 2019-08-19 | 2019-08-19 | Tray device of microfluidic sample processing equipment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021032082A1 (en) * | 2019-08-19 | 2021-02-25 | 江苏汇先医药技术有限公司 | Microfluidic sample processing device |
| CN112980983A (en) * | 2021-02-10 | 2021-06-18 | 复旦大学 | Plasmodium in-situ typing detection method, device and kit |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020110902A1 (en) * | 2001-01-26 | 2002-08-15 | Prosser Simon J. | Robotic autosampler for automated electrospray from a microfluidic chip |
| US20040033590A1 (en) * | 2002-08-13 | 2004-02-19 | Yo-Hsin Su | Array biochip workstation |
| US20090130745A1 (en) * | 2007-07-13 | 2009-05-21 | Handylab, Inc. | Integrated Apparatus for Performing Nucleic Acid Extraction and Diagnostic Testing on Multiple Biological Samples |
| US20120184025A1 (en) * | 2009-09-30 | 2012-07-19 | Eiji Kawata | Nucleic acid analyzer |
| CN203825016U (en) * | 2014-02-28 | 2014-09-10 | 深圳市第二人民医院 | Human immunodeficiency virus (HIV) detector |
| CN204302299U (en) * | 2014-12-19 | 2015-04-29 | 中宜环科仪器江苏有限公司 | Three-dimensional sample mechanical arm |
| JP2016223919A (en) * | 2015-05-29 | 2016-12-28 | ユニバーサル・バイオ・リサーチ株式会社 | Chip for chromatographic processing, chromatographic processing device, and chromatographic processing method |
| CN107843737A (en) * | 2017-12-08 | 2018-03-27 | 均强机械(苏州)有限公司 | Full-automatic micro-fluidic chemiluminescence immunoassay detector |
| CN108732367A (en) * | 2018-05-29 | 2018-11-02 | 陈金凤 | A kind of rack for test tube sampling device of medicine bio-chemical detector |
| CN109496097A (en) * | 2018-12-06 | 2019-03-19 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Grip device |
| CN109939755A (en) * | 2019-05-22 | 2019-06-28 | 上海邦先医疗科技有限公司 | A kind of multichannel tandem micro-fluidic chip clamp system |
| CN210572332U (en) * | 2019-08-19 | 2020-05-19 | 昆山汇先医药技术有限公司 | Tray device of micro-fluidic sample processing equipment |
-
2019
- 2019-08-19 CN CN201910762383.9A patent/CN110501488B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020110902A1 (en) * | 2001-01-26 | 2002-08-15 | Prosser Simon J. | Robotic autosampler for automated electrospray from a microfluidic chip |
| US20040033590A1 (en) * | 2002-08-13 | 2004-02-19 | Yo-Hsin Su | Array biochip workstation |
| US20090130745A1 (en) * | 2007-07-13 | 2009-05-21 | Handylab, Inc. | Integrated Apparatus for Performing Nucleic Acid Extraction and Diagnostic Testing on Multiple Biological Samples |
| US20120184025A1 (en) * | 2009-09-30 | 2012-07-19 | Eiji Kawata | Nucleic acid analyzer |
| CN203825016U (en) * | 2014-02-28 | 2014-09-10 | 深圳市第二人民医院 | Human immunodeficiency virus (HIV) detector |
| CN204302299U (en) * | 2014-12-19 | 2015-04-29 | 中宜环科仪器江苏有限公司 | Three-dimensional sample mechanical arm |
| JP2016223919A (en) * | 2015-05-29 | 2016-12-28 | ユニバーサル・バイオ・リサーチ株式会社 | Chip for chromatographic processing, chromatographic processing device, and chromatographic processing method |
| CN107843737A (en) * | 2017-12-08 | 2018-03-27 | 均强机械(苏州)有限公司 | Full-automatic micro-fluidic chemiluminescence immunoassay detector |
| CN108732367A (en) * | 2018-05-29 | 2018-11-02 | 陈金凤 | A kind of rack for test tube sampling device of medicine bio-chemical detector |
| CN109496097A (en) * | 2018-12-06 | 2019-03-19 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Grip device |
| CN109939755A (en) * | 2019-05-22 | 2019-06-28 | 上海邦先医疗科技有限公司 | A kind of multichannel tandem micro-fluidic chip clamp system |
| CN210572332U (en) * | 2019-08-19 | 2020-05-19 | 昆山汇先医药技术有限公司 | Tray device of micro-fluidic sample processing equipment |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021032082A1 (en) * | 2019-08-19 | 2021-02-25 | 江苏汇先医药技术有限公司 | Microfluidic sample processing device |
| CN112980983A (en) * | 2021-02-10 | 2021-06-18 | 复旦大学 | Plasmodium in-situ typing detection method, device and kit |
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| Publication number | Publication date |
|---|---|
| CN110501488B (en) | 2024-06-07 |
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Country or region after: China Address after: Room 12, no.1798, West Zhonghua Garden Road, Yushan Town, Kunshan City, Suzhou City, Jiangsu Province Applicant after: Jiangsu Huixian Pharmaceutical Technology Co.,Ltd. Address before: 215301 Room 101, No.168 Yuanfeng Road, Yushan Town, Kunshan City, Suzhou City, Jiangsu Province Applicant before: KUNSHAN HUIXIAN MEDICAL TECHNOLOGY Co.,Ltd. Country or region before: China |
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