CN110496245A - A kind of medical material and preparation method thereof for treating osteomyelitis - Google Patents
A kind of medical material and preparation method thereof for treating osteomyelitis Download PDFInfo
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- CN110496245A CN110496245A CN201910877426.8A CN201910877426A CN110496245A CN 110496245 A CN110496245 A CN 110496245A CN 201910877426 A CN201910877426 A CN 201910877426A CN 110496245 A CN110496245 A CN 110496245A
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- bone cement
- osteomyelitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
Abstract
The invention discloses a kind of medical materials for treating osteomyelitis, including the following raw material formed by weight: 1.0-100.0 parts of bone cement powder, 0.05-100.0 parts of calcium hydroxide powder, 1.0-50.0 parts of bone cement liquor.Composition of raw materials of the present invention is simple, easily obtains, advantage of lower cost, and preparation method is simple and easy to operate, and therapeutic effect is significant, and has efficient sterilizing effect and good biological safety, can satisfy clinic control and treats the needs of osteomyelitis.
Description
Technical field
The present invention relates to osteomyelitis treatment technology field, the medical material of specifically a kind for the treatment of osteomyelitis and its preparation side
Method.
Background technique
Increasingly developed with Chinese society economy, building industry and journeymen mechanics increase year by year, and motor vehicle etc. is quickly handed over
Logical tool becomes increasingly popular, and thus the high Energy Damage such as caused machine wound, Falling Injury, traffic accident wound is in rising trend, especially opens
Putting property fracture case sharply increases.Bone stump is exposed, wound contamination easily by bacteria attack, lead to that bone tissue infects or part is thin
Bacterium residual breeding.In addition high-energy damage wound caused by bone stump surrounding skin soft tissue, blood vessel is serious, leads to local blood
For destroying, easily formation sequestrum, and then " breeding ground " sticked as bacterial reproduction, bacterial biof iotalm cannot be controlled effectively for a long time
More, osteomyelitis is ultimately formed, protracted course is not cured, and treatment difficulty is big, is disabled, terateger rate height, amputation rate is high, brings to patient huge
Big pain brings heavy financial burden to family and society.
The current clinical treatment theory for osteomyelitis is, on the basis of carrying out the abundant debridement of lesion and drainage, part
And whole body gives sensitive antibiotic treatment.But since osteomyelitis lesion part blood supply is poor, and mostly formed with sequestrum, vein
Sensitive antibiotic is hard to reach lesion and is partially formed effective bacteriocidal concentration, and therapeutic effect is poor, side effect is big.Lesion locally directly makes
It is with the therapeutic modality of sensitive antibiotic, then very high to the selected performance requirement for carrying drug carrier --- it should guarantee sufficient load
Dose can be realized the stable release of sustained drug again, in this way could be raw by the bacterium for being attached to sequestrum, scar tissue surface
Object film is utterly destroyed, and then thoroughly kills pathogenic bacteria；And preferably the load drug carrier can locally play induced osteogenesis, promote bone
The therapeutic effect of reparation.
Therefore, for the above status, there is an urgent need to develop a kind of medical material and preparation method thereof for treating osteomyelitis, with
Overcome the shortcomings of in currently practical application.
Summary of the invention
The purpose of the present invention is to provide a kind of medical materials and preparation method thereof for treating osteomyelitis, to solve above-mentioned back
The problem of being proposed in scape technology.
To achieve the above object, the invention provides the following technical scheme:
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: bone cement powder 1.0-100.0
Part, 0.05-100.0 parts of calcium hydroxide powder, 1.0-50.0 parts of bone cement liquor.
As further scheme of the invention: including the following raw material formed by weight: 4.0 parts of bone cement powder,
0.65 part of calcium hydroxide powder, 2.0 parts of bone cement liquor.
As further scheme of the invention: the bone cement powder, calcium hydroxide powder and bone cement liquor are
Medical grade.
As further scheme of the invention: the model CEMEX XL1200/S of the bone cement powder, the bone
The model CEMEX XL1200/S of cement liquor.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
As further scheme of the invention: in step S3, the aperture of the moulding cavity and height are 3mm.
As further scheme of the invention: in step S3, the time of the natural coagulation is 5-10min.
Compared with prior art, the beneficial effects of the present invention are:
1) composition of raw materials of the present invention is simple, easily obtains, advantage of lower cost, and preparation method is simple and easy to operate, therapeutic effect
Significantly；
2) present invention has efficient sterilizing effect and good biological safety, can satisfy clinic control and treats the need of osteomyelitis
It wants；
3) the solid particle bone cement of the invention containing calcium hydroxide can be sustained OH-, there is Continuous sterilization effect；
4) present invention has convergence, and inducible bone tissue is formed, to promote Bone Defect Repari；
5) present invention can be mixed to form insoluble calcium phosphate with CO2 in blood and tissue fluid containing calcium hydroxide, can block infection
Small sinus, package limitation infected area, to prevent infection from spreading；
6) material of the present invention is sealed after placing ossis with simple bone cement, and bone cement surface can form induction film, promote the later period
Knitting.
Specific embodiment
Technical solution of the present invention is described in more detail With reference to embodiment.
Embodiment 1
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 5.0 parts of bone cement powder, hydrogen-oxygen
Change 0.75 part of calcium powder, 2.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 2
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 4.0 parts of bone cement powder, hydrogen-oxygen
Change 0.65 part of calcium powder, 2.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 3
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 3.5 parts of bone cement powder, hydrogen-oxygen
Change 0.85 part of calcium powder, 2.2 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 4
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 4.5 parts of bone cement powder, hydrogen-oxygen
Change 0.55 part of calcium powder, 1.8 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 5
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 3.0 parts of bone cement powder, hydrogen-oxygen
Change 0.95 part of calcium powder, 1.5 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 6
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 7.0 parts of bone cement powder, hydrogen-oxygen
Change 2.0 parts of calcium powder, 4.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 7
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 5.0 parts of bone cement powder, hydrogen-oxygen
Change 0.45 part of calcium powder, 1.3 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 8
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 3.5 parts of bone cement powder, hydrogen-oxygen
Change 0.35 part of calcium powder, 1.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 9
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 5.5 parts of bone cement powder, hydrogen-oxygen
Change 0.25 part of calcium powder, 2.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 10
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 5.0 parts of bone cement powder, hydrogen-oxygen
Change 0.2 part of calcium powder, 2.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 11
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 1.0 parts of bone cement powder, hydrogen-oxygen
Change 0.05 part of calcium powder, 1.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 5min in the present embodiment step S3.
Embodiment 12
A kind of medical material for treating osteomyelitis, including the following raw material formed by weight: 100.0 parts of bone cement powder, hydrogen
100.0 parts of lime powder, 50.0 parts of bone cement liquor.
Specifically, the bone cement powder, calcium hydroxide powder and bone cement liquor are medical grade in the present embodiment.
Specifically, in the present embodiment, the model CEMEX XL1200/S of the bone cement powder, the bone cement liquor
Model CEMEX XL1200/S.
A kind of preparation method of the medical material of the treatment osteomyelitis, comprising the following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
Specifically, the aperture of the moulding cavity and height are 3mm in the present embodiment step S3.
Specifically, the time of the natural coagulation is 10min in the present embodiment step S3.
It practices case 1: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 1 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 2: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 2 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 3: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 3 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 4: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 4 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 5: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 5 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 6: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 6 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 7: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 7 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 8: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 8 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 9: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement, A group place the medical material of the treatment osteomyelitis according to 9 configuration proportion of embodiment, then use bone
Grout off pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 10: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement is given, A group is placed the medical material of the treatment osteomyelitis according to 10 configuration proportion of embodiment, then used
Bone cement blocks pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 11: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement is given, A group is placed the medical material of the treatment osteomyelitis according to 11 configuration proportion of embodiment, then used
Bone cement blocks pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
It practices case 12: taking 6 White Rabbit femur bone marrow inflammation models, be randomly divided into tri- groups of A, B, C, every group two, give
Repeated flushing after thorough debridement is given, A group is placed the medical material of the treatment osteomyelitis according to 12 configuration proportion of embodiment, then used
Bone cement blocks pulp cavity；B group gives appropriate gentamicin filling；C group directly seals pulp cavity with bone cement.
Test result: the postoperative 7 days above-mentioned A group rabbit wound all healeds practiced in case, wherein practice case 1,9,
There is slight redness in 10 rabbit wounds, but ooze out without fester, cure without recurrence, thoroughly within continuous observation 3 months；Postoperative 4 Lepus of B group
All there is different degrees of redness, skin gradually ulceration, or even formation sinus, constantly exudation suppurative liquid, infection and recurrence in sub- wound；
Postoperative 3 days all rabbit wounds of C group start different degrees of redness occur to fester, and a large amount of festers exudations, postoperative 7 days all dead.A
Group curative effect is substantially better than B group and C group, and well compared with C group, difference is statistically significant for B group curative effect.
Better embodiment of the invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (7)
1. a kind of medical material for treating osteomyelitis, which is characterized in that including the following raw material formed by weight: bone cement powder
1.0-100.0 parts last, 0.05-100.0 parts of calcium hydroxide powder, 1.0-50.0 parts of bone cement liquor.
2. the medical material for the treatment of osteomyelitis according to claim 1, which is characterized in that formed by weight including following
Raw material: 4.0 parts of bone cement powder, 0.65 part of calcium hydroxide powder, 2.0 parts of bone cement liquor.
3. the medical material for the treatment of osteomyelitis according to claim 2, which is characterized in that the bone cement powder, hydrogen-oxygen
Change calcium powder and bone cement liquor is medical grade.
4. the medical material for the treatment of osteomyelitis according to claim 3, which is characterized in that the model of the bone cement powder
For CEMEX XL1200/S, the model CEMEX XL1200/S of the bone cement liquor.
5. a kind of preparation method of the medical material of the treatment osteomyelitis as described in claim 1-4 is any, which is characterized in that packet
Include following steps:
S1, each raw material is weighed by weight；
S2, aseptically, each raw material is mixed, and is sufficiently stirred until at paste；
S3, paste mixture is filled in moulding cavity, natural coagulation condenses into solid particle afterwards for a period of time to get described
The medical material of osteomyelitis is treated, then solid particle is put into the osteomyelitis pulp cavity after the debridement of bottom, and with simple bone cement
It blocks, sews up a wound.
6. the preparation method of the medical material for the treatment of osteomyelitis according to claim 5, which is characterized in that in step S3,
The aperture of the moulding cavity and height are 3mm.
7. the preparation method of the medical material for the treatment of osteomyelitis according to claim 5, which is characterized in that in step S3,
The time of the natural coagulation is 5-10min.
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