CN110496242A - A kind of rapid hemostatic material based on nucleopore membranes - Google Patents
A kind of rapid hemostatic material based on nucleopore membranes Download PDFInfo
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- CN110496242A CN110496242A CN201910895909.0A CN201910895909A CN110496242A CN 110496242 A CN110496242 A CN 110496242A CN 201910895909 A CN201910895909 A CN 201910895909A CN 110496242 A CN110496242 A CN 110496242A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/12—Layered products comprising a layer of synthetic resin next to a fibrous or filamentary layer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Chemical & Material Sciences (AREA)
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Abstract
The invention discloses a kind of rapid hemostatic materials based on nucleopore membranes, including hemostatic layer, are disposed with nucleopore membranes and water absorption layer in the lower surface of hemostatic layer.The present invention uses filter layer of the nucleopore membranes as blood, the effectively hemostatic composition such as blood platelet in blood and red blood cell can be trapped in hemostatic layer side, and the small molecule of water etc is only allowed to pass through, increase effective hemostatic compositions concentration, plays the effect of concentrate blood quick-acting haemostatic powder.Meanwhile the hemostatic material also possess prepare simple, cheap, safe and non-toxic, scar is small, use when without the advantages that feeling of burning.
Description
Technical field
The present invention relates to medical material fields, and in particular to a kind of rapid hemostatic material based on nucleopore membranes.
Background technique
Traumatic hemorrhage is always the main reason for leading to death in field battlefield and all kinds of major traffic accidents.Especially
It is in severe war environment and burst incident complicated and changeable, even if if thering is medical staff to be on the scene the bleeding feelings of patient
Condition does not obtain good inhibition, still suffers from the very high death rate and late complication.Therefore in no good medical item
When part first aid, realize that quickly and effectively hemostasis is of great significance.A kind of ideal rapid hemostatic material should have following several
A feature: being 1. used directly for wound face, and main artery and phleborrhagia are controlled in 2-3min；2. using material safety,
Bacterium or cell superinfection will not be generated；3. not needing the follow-up works such as to be prepared and mixed before use；4. using being not required to
Training, easily operated, Non-medical-staff can also be used skillfully in complex environment；5. convenient for carrying；It is cheap.
Main hemostatic material can be divided into three classes by hemostatic mechanism currently on the market: the first kind is the blood coagulation of fibrin class
Material, fibrinogen of the material containing high concentration itself, fibrin ferment, can accelerate in human body final step Coagulation test to
Realize hemostatic function, but its disadvantage is that environmental suitability is poor, expensive, storage time is short；Second class is alpha-cyanoacrylate
Esters, material main function mechanism is sealing bleeding wound site to reach anastalsis, but it is very high to operation requirement；
These two types of materials use obvious deficiency for fine when hospital uses in complicated outdoor environment.Third class is more micropores
Class inorganic material and high molecular polysaccharide achieve the purpose that quick-acting haemostatic powder by promoting wound site itself blood coagulation.Wherein, more
Micropore class inorganic material hemostatic mechanism is the moisture absorbed in blood to improve red blood cell in blood, blood platelet and coagulation factor
Concentration wound site can be generated and be burnt but the disadvantage is that a large amount of thermal energy can be released after absorbing moisture.Macromolecule polysaccharide
Most popular class hemostatic material is chitosan, and hemostatic mechanism does not depend on coagulation factor, but with the red blood cell in blood
To form sludged blood blocking wound Deng acting on by physical crosslinking and stop blooding, but also have lighter weight be difficult to blutpunkte it is fixed and
Later period wound face is difficult to the deficiencies of handling.
United States Patent (USP) US2009/018685 1A1 describes a kind of graininess chitosan hemostatic material (formation product
Celox styptic powder), there is significant effect compared with gash bleeding to larger, U.S. army's first-aid dressing is included in by the U.S. in 2010
Standard content object.But Celox hemostasis granules shape lighter weight, saves oneself in severe complex environment calumniator and is difficult to be fixed in
Blutpunkte, haemostatic effect are difficult to play, and its particulate matter can be attached to wound surface, increase later period treatment of wounds difficulty.
107412843 A of Chinese patent CN (publication date: on December 1st, 2017) discloses a kind of with anti-microbial property
Starch base micropore hemostatic material.The material first prepares micropore starch, then loads amino ion, and prepared poromerics stops
Quickly absorb water concentrate blood when blood, has antibacterial functions again while hemostasis, can be with accelerating wound healing.But it is being absorbed
A large amount of thermal energy can be discharged when moisture in blood, and then will lead to the burn of tissue, influence therapeutic effect.
102648985 B of Chinese patent CN (publication date: on March 26th, 2014), which discloses a kind of Chitosan first aid, to be stopped
Blood material, using chitosan as hemostatic layer, Sodium Polyacrylate grafted chitosan laying and water absorption layer, but Sodium Polyacrylate is grafted
Chitosan is only a component of material, and only limited come concentrate blood effect by its water absorbing capacity, quick-acting haemostatic powder is ineffective.
Summary of the invention
The purpose of the present invention is overcome the deficiencies of the prior art and provide a kind of rapid hemostatic material based on nucleopore membranes.
Technical solution of the present invention is summarized as follows:
A kind of rapid hemostatic material based on nucleopore membranes, including hemostatic layer 1 are disposed with core in the lower surface of hemostatic layer
Pore membrane 2 and water absorption layer 3.
Nucleopore membranes top surface edge is connect by adhesive with hemostatic layer, and nucleopore membranes lower surface edge is by adhesive and inhales
Water layer connection.
Adhesive preferred starch, polyester, acrylic acid or latex.
Preferably, hemostatic layer is made of following methods: hemostasis component is added in deionized water, mixed liquor is made in stirring,
Supporting layer is immersed in mixed liquor, 10-30min is impregnated, is taken out, freeze-drying.
Hemostasis group is divided into Yunnan Baiyao powder, chitosan shield creates powder, pseudo-ginseng hemostatic dissipates and one kind or several of Colox styptic powder
Kind.
Supporting layer is hospital gauze or degreasing cotton yarn.
For nucleopore membranes with a thickness of 10~30 μm, aperture is 1~5 μm, and hole density is 4 × 102/cm2~8.0 × 1010/cm2。
Water absorption layer is hospital gauze or degreasing cotton yarn.
The beneficial effects of the present invention are:
1. the present invention, can be according to nucleopore membranes using nucleopore membranes on the basis of using hemostasis component is stopped blooding in hemostatic layer
Aperture carry out selectivity filtering, make effective hemostatic compositions such as blood platelet and the red blood cell in blood, stay in hemostatic layer side,
Make the moisture in blood through nucleopore membranes, achievees the purpose that the concentrate blood in hemostatic layer, to accelerate to stop blooding.
2. water absorption layer of the invention can rapidly water absorbing capacity, increase nucleopore membranes two sides permeable pressure head improve blood using it
Moisture in liquid penetrates the rate of nucleopore membranes, accelerates the dense of concentration hemostatic layer side blood platelet and red blood cell etc. effectively hemostatic compositions
Degree makes it easier to assemble in blutpunkte, quick-acting haemostatic powder.
3. haemostatic effect of the present invention is significant, have it is easy to operate, cheap, safe and non-toxic, use when without sense of burning, scar
The advantages that trace is small, without particle attachment.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the rapid hemostatic material based on nucleopore membranes of the present invention.
Specific embodiment
Nucleopore membranes are purchased from Tianjin Li Yuan Science and Technology Ltd., and material is polyester material.
Yunnan Baiyao powder is purchased from Yunnan Paiyao Group Corp., Ltd.
Chitosan shield wound powder, is purchased from Dezhou Haili'an Biotechnology Co., Ltd..
Pseudo-ginseng hemostatic dissipates, and is purchased from the prosperous Lu Da medical supplies in Anhui Co., Ltd.
Colox styptic powder is purchased from Medtrade Products Limited.
The production firm of above-mentioned material of the present invention and material are to enable those skilled in the art to more fully understand
The present invention, but the present invention is not limited in any way, substance similar with above-mentioned material property can be used for the present invention, and be
Protection scope of the present invention.
Hemostatic layer is made of following methods: hemostasis component being added in deionized water, stirring, it is 100mg/ that concentration, which is made,
Supporting layer is immersed in the mixed liquor by the mixed liquor of mL-300mg/mL, and supporting layer and hemostasis constituent mass ratio are 100:5-
20,10-30min is impregnated, is taken out, freeze-drying.
The present invention is further illustrated with reference to the accompanying drawings and examples.
Embodiment 1
A kind of rapid hemostatic material based on nucleopore membranes, including hemostatic layer 1 are disposed with core in the lower surface of hemostatic layer
Pore membrane 2 and water absorption layer 3 (see Fig. 1).
Nucleopore membranes top surface edge is connect by binder starch with hemostatic layer, and nucleopore membranes lower surface edge passes through adhesive
Starch is connect with water absorption layer.
Hemostatic layer is made of following methods:
Hemostasis component Colox styptic powder is added in deionized water, the mixed liquor of concentration 200mg/mL is made in stirring, will
Supporting layer hospital gauze is immersed in mixed liquor, and the mass ratio of hospital gauze and Colox styptic powder is 100:10, impregnates 20min,
It takes out, freeze-drying.
For nucleopore membranes with a thickness of 20 μm, aperture is 3 μm, and hole density is 3.0 × 1010/cm2。
Water absorption layer is hospital gauze.
Embodiment 2
A kind of rapid hemostatic material based on nucleopore membranes, including hemostatic layer 1 are disposed with core in the lower surface of hemostatic layer
Pore membrane 2 and water absorption layer 3.
Nucleopore membranes top surface edge is connect by bonding agent emulsion with hemostatic layer, and nucleopore membranes lower surface edge passes through adhesive
Latex is connect with water absorption layer.
Hemostatic layer is made of following methods:
Hemostasis component Yunnan Baiyao powder is added in deionized water, stirring is made the mixed liquor of concentration 100mg/mL, will prop up
Support layer degreasing cotton yarn is immersed in mixed liquor, and the mass ratio of degreasing cotton yarn and Yunnan Baiyao powder is 100:5, is impregnated 10min, is taken
Out, it is freeze-dried.
For nucleopore membranes with a thickness of 30 μm, aperture is 5 μm, and hole density is 4.0 × 102/cm2。
Water absorption layer is degreasing cotton yarn.
Embodiment 3
A kind of rapid hemostatic material based on nucleopore membranes, including hemostatic layer 1 are disposed with core in the lower surface of hemostatic layer
Pore membrane 2 and water absorption layer 3.
Nucleopore membranes top surface edge is connect by adhesive acrylic acid with hemostatic layer, and nucleopore membranes lower surface edge passes through bonding
Agent acrylic acid is connect with water absorption layer.
Hemostatic layer is made of following methods:
Hemostasis component pseudo-ginseng hemostatic is dissipated and is added in deionized water, stirring is made the mixed liquor of concentration 300mg/mL, will prop up
Support layer hospital gauze is immersed in mixed liquor, and hospital gauze is 100:20 with the mass ratio that pseudo-ginseng hemostatic dissipates, and is impregnated 30min, is taken
Out, it is freeze-dried.
For nucleopore membranes with a thickness of 10 μm, aperture is 1 μm, and hole density is 8.0 × 1010/cm2。
Water absorption layer is hospital gauze.
The acrylic acid for looking for the present embodiment, the chitosan for mass ratio being 1:1 shield wound powder and pseudo-ginseng hemostatic is replaced to dissipate with polyester
The pseudo-ginseng hemostatic that composition substitutes the present embodiment dissipates, and other same the present embodiment can be prepared a kind of based on the quick of nucleopore membranes
Hemostatic material.
Haemostatic effect evaluation:
1, rabbit ear edge arteriovenous wound hemorrhage model
Taking the new zealand white rabbit (coagulation function is normal) of 20 health, adult, average weight is in 2-3kg, half male and half female,
It is randomly divided into 5 groups, i.e. blank group, embodiment 1, embodiment 2, embodiment 3, Colox styptic powder.
The Nembutal sodium solution of anesthetic selection 3% after rabbit weighing, calculates anesthetic in the ratio of 1ml/kg and uses
Amount, is anaesthetized using auricular vein injection method.After rabbit anesthesia, with 75% ethanol disinfection, use scalpel in ear afterwards
1cm × 1cm size surface of a wound is done in outside center, is stopped blooding immediately by grouping after blood is filled with the entire surface of a wound, record hemostasis
Time simultaneously calculates hemostasis amount.
Bleeding stopping period recording method: in bleeding surface of a wound apply pressure and fixed hemostatic material, one layer of medical yarn is covered again in periphery
Cloth, and certain pressure compression is given, until no longer bleeding, records bleeding stopping period.
Amount of bleeding calculation method: the matter of hemostasis front and back hemostatic material and covering hospital gauze is weighed respectively with assay balance
Amount, the calculation formula of amount of bleeding are as follows: cover hospital gauze quality after amount of bleeding (g)=hemostasis after hemostatic material quality (g)+hemostasis
(g) hospital gauze quality (g) is covered before-preceding hemostatic material quality (g)-hemostasis of stopping blooding.
Table 1: hemostatic material of the present invention and other hemostatic materials are to new zealand rabbit ear edge arteriovenous wound hemostasis time and mistake
Blood volume compares
| Group | Bleeding stopping period (s) | Blood loss (g) |
| Blank control group | 810±30 | 7.9568±0.003 |
| Celox group | 40±2 | 0.0186±0.002 |
| Embodiment 1 | 27±1 | 0.0085±0.002 |
| Embodiment 2 | 25±1 | 0.0062±0.002 |
| Embodiment 3 | 29±1 | 0.0093±0.002 |
As shown in table 1, compared with blank control group, Celox group, embodiment have significant difference, the embodiment of the present invention
Hemostatic material group and Celox styptic powder group ratio have significant difference, and bleeding stopping period and blood loss are better than Celox styptic powder
Group.2, rabbit femoral artery bleeding animal model
Taking the new zealand white rabbit (coagulation function is normal) of 20 health, adult, average weight is in 2-3kg, half male and half female,
It is randomly divided into 5 groups, i.e. blank group, embodiment 1, embodiment 2, embodiment 3, Colox styptic powder.
The Nembutal sodium solution of anesthetic selection 3% after rabbit weighing, calculates anesthetic in the ratio of 1ml/kg and uses
Amount, is anaesthetized using auricular vein injection method.Rabbit is fixed on operating table after anesthesia, remove leg hours is carried out, is used in combination
75% ethanol disinfection.Leg skin is cut off, femoral artery is carried out using scalpel laterally to cut 3/4, blood is made to gush
And go out, stopped blooding immediately using hemostatic material after bleeding 3 seconds, and record bleeding stopping period and hemostasis amount.
Table 2: novel hemostatic material and other hemostatic materials are to new zealand rabbit femoral artery wound hemostasis time and blood loss ratio
Compared with
| Group | Bleeding stopping period (s) | Blood loss (g) |
| Blank control group | Without hemostasis | Without hemostasis |
| Celox group | 53±4 | 30.716±0.376 |
| Embodiment 1 | 33±3 | 20.269±0.257 |
| Embodiment 2 | 31±3 | 18.495±0.314 |
| Embodiment 3 | 37±3 | 23.326±0.365 |
As shown in table 2, compared with blank control group, Celox group, embodiment have significant difference；The embodiment of the present invention
Hemostatic material group and Celox styptic powder group ratio have significant difference, and bleeding stopping period and blood loss are better than Celox styptic powder
Group.
To sum up the hemostasis of above-mentioned new zealand rabbit the experimental results showed that, it is of the present invention to be stopped blooding based on nucleopore membranes hemostatic material
Time and control amount of bleeding in terms of effect be superior to Celox powder, and it is easy to operate be easily fastened at blutpunkte, more be applicable in
In field emergency hemostasis operation.
Claims (8)
1. a kind of rapid hemostatic material based on nucleopore membranes, including hemostatic layer (1), it is characterized in that the lower surface of hemostatic layer successively
It is provided with nucleopore membranes (2) and water absorption layer (3).
2. a kind of rapid hemostatic material based on nucleopore membranes according to claim 1, it is characterized in that table in the nucleopore membranes
Face edge is connect by adhesive with hemostatic layer, and nucleopore membranes lower surface edge is connect by adhesive with water absorption layer.
3. a kind of rapid hemostatic material based on nucleopore membranes according to claim 2, it is characterized in that described adhesive is to form sediment
Powder, polyester, acrylic acid or latex.
4. a kind of rapid hemostatic material based on nucleopore membranes according to claim 1 or 2, it is characterized in that the hemostatic layer
It is made of following methods: hemostasis component is added in deionized water, mixed liquor is made in stirring, supporting layer is immersed in described mixed
It closes in liquid, impregnates 10-30min, take out, freeze-drying.
5. a kind of rapid hemostatic material based on nucleopore membranes according to claim 4, it is characterized in that the hemostasis component
For Yunnan Baiyao powder, chitosan shield wound powder, pseudo-ginseng hemostatic dissipates and the one or more of Colox styptic powder.
6. a kind of rapid hemostatic material based on nucleopore membranes according to claim 4, it is characterized in that the supporting layer is doctor
With gauze or degreasing cotton yarn.
7. a kind of rapid hemostatic material based on nucleopore membranes according to claim 1, it is characterized in that the nucleopore film thickness
It is 10~30 μm, aperture is 1~5 μm, and hole density is 4 × 102/cm2~8.0 × 1010/cm2。
8. a kind of rapid hemostatic material based on nucleopore membranes according to claim 1, it is characterized in that the water absorption layer is
Hospital gauze or degreasing cotton yarn.
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Cited By (1)
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| CN114699926A (en) * | 2022-03-31 | 2022-07-05 | 邻得膜(厦门)医疗科技有限公司 | PRF preparation device and preparation method |
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| CN114699926A (en) * | 2022-03-31 | 2022-07-05 | 邻得膜(厦门)医疗科技有限公司 | PRF preparation device and preparation method |
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Application publication date: 20191126 |