CN110496195B - 一种治疗顽固性失眠的中药组合物 - Google Patents
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Abstract
本发明涉及治疗顽固性失眠的中药组合物，可有效解决顽固性失眠的用药问题，其解决的技术方案是，由以下重量计的原料药物制成：黄芪20‑40g、党参10‑20g、茯神12‑28g、远志4‑8g、炒酸枣仁20‑40g、龙眼肉8‑16g、山萸肉10‑20g、当归8‑16g、桑椹20‑40g、清半夏10‑20g、高粱米20‑40g、合欢花6‑14g、代代花6‑14g、黄连1‑4g和甘草4‑8g，本发明全方合用，健脾以资化源，养血以宁心神，理气以疏肝醒脾，共奏气血双补，健脾养心之功，用药安全，无毒副作用，治疗效果好，是顽固性失眠药物上的创新。
Description
技术领域
本发明涉及医药领域，特别是一种治疗顽固性失眠的中药组合物。
背景技术
顽固性失眠为中医脑病门诊颇为常见的一种疾病，临证时以心脾两虚，阴阳失调引起者居多。因失眠患者以脑力劳动者居多，从事脑力劳动者，往往爱思考问题，思虑过度，耗伤心脾，心血暗耗，则神不守舍；脾虚生化乏源，营血亏虚，则不能奉养心神，而致反复失眠。《类证治裁•不寐》说：“思虑伤脾,脾血亏损，经年不寐。”又失眠患者往往压力较大，心情郁郁不乐，郁久则肝郁脾虚，脾虚易生湿蕴痰，痰湿化热，热扰心神则失眠。目前，市场上安眠药物治标不治本，病情易反复，治疗效果不理想，因此，顽固性失眠药物上的改进是目前亟需解决的问题。
发明内容
针对上述情况，为解决现有技术之缺陷，本发明之目的就是提供一种治疗顽固性失眠的中药组合物，可有效解决顽固性失眠的用药问题。
本发明解决的技术方案是，由以下重量计的原料药物制成：黄芪20-40g、党参10-20g、茯神12-28g、远志4-8g、炒酸枣仁20-40g、龙眼肉8-16g、山萸肉10-20g、当归8-16g、桑椹20-40g、清半夏10-20g、高粱米20-40g、合欢花6-14g、代代花6-14g、黄连1-4g和甘草4-8g。
本发明全方合用，健脾以资化源，养血以宁心神，理气以疏肝醒脾，共奏气血双补，健脾养心之功，用药安全，无毒副作用，治疗效果好，是顽固性失眠药物上的创新。
具体实施方式
以下结合实施例对本发明的具体实施方式作进一步详细说明。
实施例1
本发明在具体实施时，可由以下重量计的原料药物制成：黄芪21g、党参11g、茯神13g、远志5g、炒酸枣仁21g、龙眼肉9g、山萸肉11g、当归9g、桑椹21g、清半夏11g、高粱米21g、合欢花7g、代代花7g、黄连2g和甘草5g。
实施例2
本发明在具体实施时，还可由以下重量计的原料药物制成：黄芪30g、党参15g、茯神20g、远志6g、炒酸枣仁30g、龙眼肉12g、山萸肉15g、当归12g、桑椹30g、清半夏15g、高粱米30g、合欢花10g、代代花10g、黄连3g和甘草6g。
实施例3
本发明在具体实施时，还可由以下重量计的原料药物制成：黄芪39g、党参19g、茯神27g、远志7g、炒酸枣仁39g、龙眼肉15g、山萸肉19g、当归15g、桑椹39g、清半夏19g、高粱米39g、合欢花13g、代代花13g、黄连4g和甘草7g。
本发明中药组合物可根据临床实际的需要，按常规制备方法制成汤剂、粉剂（散剂）、片剂、颗粒剂、丸剂、胶囊剂等适于应用的各种剂型，下边给出常规方法制成的汤剂，具体是：先将黄芪、党参、茯神、远志、炒酸枣仁、龙眼肉、山萸肉、当归、桑椹、清半夏、高粱米、合欢花、代代花、黄连和甘草混合在一起，放入药罐中，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，合并两次滤液，混匀即成。
本发明组方中黄芪、党参、甘草健脾益气；酸枣仁、远志、茯神、龙眼肉、山萸肉补益心脾，安神定志；当归、桑椹养血安神；合欢花、代代花理气醒脾，使补而不滞；黄连少量为反佐，能清心安神以防止大队温燥药上火；清半夏、高粱米二者相配为半夏秫米汤，有健脾燥湿，和胃安神之功，能使卫气由阳入阴，使阳跷脉由盛转平，以致阴平阳秘，而使人入眠。全方合用，健脾以资化源，养血以宁心神，理气以疏肝醒脾，共奏气血双补，健脾养心之功。利用各位中药的协同作用治疗顽固性失眠，对人体无毒无害，疗效好，用药安全，并经临床实验得到了充分证明，有关临床实验资料如下：
本发明中药组合物以汤剂为例，
1 临床资料
1.1病例资料 选取失眠患者120例，其中男性42例，女性78例；年龄最大75岁，最小18岁，平均年龄52.6±2.5岁；病程0.5-12年。
1.2诊断标准 参照国家中医药管理局2019年发布的《中医病证诊断疗效标准》中心脾两虚型不寐的诊断标准。
（1）以失眠健忘，心悸不安，面色少华，头晕乏力，少寐多梦为主症。
（2）舌质淡，苔薄白，脉细弦或细弱。
（3）经各系统和实验室检查未发现异常者。
1.3纳入标准：①符合失眠的诊断标准；②年龄在18-75岁；③同意参加实验。
1.4排除标准：①年龄在18周岁以下或75周岁以上者；②妊娠期妇女；③合并有心血管、肺、肝、肾和造血系统等严重疾病者；④神经系统器质性病变或恶性肿瘤引起的失眠。
2 治疗方案
服用本发明实施例2制成的中药汤剂，睡前1小时和早饭后1小时温服，每次150-200ml，10为一个疗程，服药2-5个疗程后统计疗效，治疗期间，忌食生冷、油腻、辛辣食物。
3疗效判定标准 参照国家中医药管理局2019年发布的《中医病证诊断疗效标准》中不寐的疗效评定标准。
（1）治愈：睡眠正常，且伴有症状消失。
（2）好转：睡眠时间延长，且伴有症状改善。
（3）未愈：症状未改变。
4 结果 共120例患者，治愈37例，显效76例，无效7例，总有效率为94.17%。
本发明中药组方经制成其他剂型或其他实施例，在实验中均取得了相同或相近的结果，不再一一列举，防止累述，而且，本申请请求保护的是中药组方（组合发明），而不在于剂型或制备方法，因此，凡采用本申请中药组方制成的任一剂型，并用于治疗顽固性失眠的药物，均属于本申请保护的范围。
5、结论
本发明组份科学，原料丰富，价格低廉，合理配伍，互相支持，诸药共奏气血双补，健脾养心之功，有效用于治疗心脾两虚，阴阳失调引起的顽固性失眠，对人体无毒无害，疗效好，用药安全，有效率高达94%以上，是中药上的一大创新，具有实际的临床意义。
Claims (4)
1.一种治疗顽固性失眠的中药组合物，其特征在于，由以下重量计的原料药物制成：黄芪20-40g、党参10-20g、茯神12-28g、远志4-8g、炒酸枣仁20-40g、龙眼肉8-16g、山萸肉10-20g、当归8-16g、桑椹20-40g、清半夏10-20g、高粱米20-40g、合欢花6-14g、代代花6-14g、黄连1-4g和甘草4-8g。
2.根据权利要求1所述的治疗顽固性失眠的中药组合物，其特征在于，由以下重量计的原料药物制成：黄芪21g、党参11g、茯神13g、远志5g、炒酸枣仁21g、龙眼肉9g、山萸肉11g、当归9g、桑椹21g、清半夏11g、高粱米21g、合欢花7g、代代花7g、黄连2g和甘草5g。
3.根据权利要求1所述的治疗顽固性失眠的中药组合物，其特征在于，由以下重量计的原料药物制成：黄芪30g、党参15g、茯神20g、远志6g、炒酸枣仁30g、龙眼肉12g、山萸肉15g、当归12g、桑椹30g、清半夏15g、高粱米30g、合欢花10g、代代花10g、黄连3g和甘草6g。
4.根据权利要求1所述的治疗顽固性失眠的中药组合物，其特征在于，由以下重量计的原料药物制成：黄芪39g、党参19g、茯神27g、远志7g、炒酸枣仁39g、龙眼肉15g、山萸肉19g、当归15g、桑椹39g、清半夏19g、高粱米39g、合欢花13g、代代花13g、黄连4g和甘草7g。
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