CN110496066A - A kind of preparation method of the water-soluble ceramide applied to cosmetics - Google Patents
A kind of preparation method of the water-soluble ceramide applied to cosmetics Download PDFInfo
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- CN110496066A CN110496066A CN201910857858.2A CN201910857858A CN110496066A CN 110496066 A CN110496066 A CN 110496066A CN 201910857858 A CN201910857858 A CN 201910857858A CN 110496066 A CN110496066 A CN 110496066A
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- ceramide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of preparation methods of ceramide, and in particular to a kind of preparation method of the water-soluble ceramide applied to cosmetics.Solve the problems, such as that current ceramide is applied in aqueous cosmetic dehydrated alcohol is added into ceramide first, and be uniformly dispersed using difficulty, formed solution one；Secondly, the hydroxypropyl beta cyclodextrin of certain mass is dissolved in water, solution two is formed；Then, solution one is slowly added dropwise into solution two, forms suspension；Finally, the liquid of acquisition is concentrated, dehydrated alcohol is removed, surplus materials is dried, the water-soluble ceramide product for aqueous cosmetic is obtained.Ceramide is wrapped up using hydroxypropyl beta cyclodextrin, so that ceramide is dissolved in the water, during use is added, after touching skin surface, after moisture evaporation, ceramide is present in skin surface, plays the role of protecting skin.
Description
Technical field
The present invention relates to a kind of preparation methods of ceramide, and in particular to a kind of water-soluble nerve applied to cosmetics
The preparation method of amide.
Background technique
Ceramide is also known as sphingolipid, is the master of lipoid between being present in the outermost corneocyte of human skin
Constituent (> 50%) is wanted, is played an important role in epidermal keratinocytes layer formation process.Playing prevents moisture from distributing and externally
Portion stimulates the important function for having safeguard function, carries protection skin and moistens, moisture-keeping functions, is that (nerve) sphingolipid is shared
Structural units.Fatty acid has the structure of sour amido bond on the amino of sphingol.On it if combining sugar, just become sheath sugar
Lipid, if just becoming (nerve) sphingomyelins in conjunction with phosphocholine.Ceramide is the mesostate of sphingolipid, especially
Occupy important position in biosynthesis.Research in recent years shows drying, furfur, cracking phenomena, barrier function occur when skin
When can be substantially reduced, skin supplement ceramide can restore rapidly moisturizing and barrier function.Also it is pointed out there are many research report, it can
By using the external plaster class product containing ceramide, to achieve the purpose that prevent anaphylaxis dermatosis and inhibit melanin foxiness
Effect.As the age increases and enters the senescence phase, ceramide present in human skin can be reduced gradually, dry skin and
The appearance of the skin abnormalities symptom such as coarse skin type is also due to caused by the reduction of ceramide amount.Therefore to prevent this kind of skin different
Often, supplement ceramide is comparatively ideal method.
The classification of ceramide includes fermentation ceramide and plant extracts ceramide, fermentation ceramide in 2017
Sale ratio be about 64.3%, the principal manufacturer for the ceramide that ferments be win wound, Doosan etc..
Ceramide is widely used in cosmetics, food, drug and other products.The ceramide of maximum ratio is for making up
Product, consumption proportion in 2017 are about 67%.Global environment factor, such as aging of population and living-pattern preservation, it is contemplated that will
Further promote the positive growth of industry.
The Asian-Pacific area is the largest area of consumption, and selling market share in 2017 is close to 35.7%.India and China are personal
The growth of nursing industry estimated grows beyond time span of forecast for push this area plus the growth of Japan and South Korea's elderly population.
After the Asian-Pacific area, Europe is the second largest area of consumption, and the income market share is 32%.
Although ceramide is using frequently in cosmetics, ceramide is easily soluble in coil neutralization lotion, in water
Property cosmetics in not readily dissolve, relative difficulty is used, in consideration of it, the present invention, by relation technological researching, preparation is water-soluble
Ceramide product, is exclusively used in aqueous cosmetic.
Summary of the invention
It is applied to for current ceramide using difficult problem in aqueous cosmetic, the present invention proposes that one kind is applied to
The preparation method of water-soluble ceramide in cosmetics, the technology mainly pass through inclusion technique, traditional neural amide are produced
Product are prepared into water-soluble ceramide product, are more suitable for using in aqueous cosmetic.
The technical solution of the present invention is to provide a kind of preparation methods of water-soluble ceramide applied to cosmetics, including
Following steps:
Step 1: dehydrated alcohol is added into neural amide products, and it is uniformly dispersed, forms solution one；
Step 2: weighing the hydroxypropyl beta cyclodextrin of certain mass, and it is dissolved in water, forms solution two；
Step 3: solution two is added in colloid mill, colloid mill is opened, solution one is slowly added dropwise into solution two, formed
Suspension, after being added dropwise to complete, colloid mill runs setting time, includes ceramide sufficiently by hydroxypropyl beta cyclodextrin；
Step 4: the liquid that step 3 obtains is concentrated, dehydrated alcohol is removed, surplus materials is dried, is obtained
To the water-soluble ceramide product for aqueous cosmetic.
Further, the volume of dehydrated alcohol is 2-3 times of ceramide small product size in step 1.
Further, the quality of hydroxypropyl beta cyclodextrin is 2-4 times of ceramide product quality in step 2；Water is added
Quality be 3-5 times of hydroxypropyl beta cyclodextrin quality.
Further, colloid mill operates to 15-30 minutes in step 3.
Further, in order to improve drying efficiency, drying means is spray drying.Ceramide is in long-time high-temperature condition
Under be easily destroyed, content reduce.Spray drying enters equipment from liquid and only needs 10-20 seconds time out to powder, and product is not
It destroys, spray-drying efficiency is high, time saving to save trouble and at low cost.
The beneficial effects of the present invention are:
Ceramide is fat-soluble product, is easily soluble in oil, and the present invention wraps up neural acyl using hydroxypropyl beta cyclodextrin
Amine, so that ceramide is dissolved in the water, during aqueous cosmetic use is added, after touching skin surface, moisture
After evaporation, ceramide is present in skin surface, plays the role of protecting skin.
Specific embodiment
The present invention is further described through with reference to embodiments.
Embodiment one
The present embodiment is realized by following steps:
Step 1: taking 1kg content is 40% ceramide, 2L dehydrated alcohol is added into the ceramide and disperses equal
It is even；
Step 2: taking 2kg hydroxypropyl beta cyclodextrin, 6L drinking water is added to dissolve；
Step 3: opening colloid mill, hydroxypropyl beta cyclodextrin aqueous solution is added, slowly into hydroxypropyl beta cyclodextrin aqueous solution
The liquid that step 1 obtains is added, adds rear equipment and runs 20 minutes；
Step 4: carrying out concentration and recovery ethyl alcohol to the liquid that step 3 obtains, obtain after condensed cream spray drying for water
Property cosmetics water-soluble ceramide product, the dehydrated alcohol that steams in concentration process is recycled.
The product of 1g step 4 is weighed, after 100ml water is added, aqueous solution clarification is bright.
Embodiment two
The present embodiment is realized by following steps:
Step 1: taking the self-produced content of 1kg our company is 40% ceramide, 3L dehydrated alcohol point is added into the ceramide
It dissipates uniform；
Step 2: taking 4kg hydroxypropyl beta cyclodextrin, 20L drinking water is added to dissolve；
Step 3: opening colloid mill, hydroxypropyl beta cyclodextrin aqueous solution is added, slowly into hydroxypropyl beta cyclodextrin aqueous solution
The liquid that step 1 obtains is added, adds rear equipment and runs 15 minutes；
Step 4: carrying out concentration and recovery ethyl alcohol to the liquid that step 3 obtains, obtain after condensed cream spray drying for water
Property cosmetics water-soluble ceramide product, the dehydrated alcohol that steams in concentration process is recycled.
The product of 1g step 4 is weighed, after 100ml water is added, aqueous solution is also clarified bright.
Embodiment three
The present embodiment is realized by following steps:
Step 1: taking the self-produced content of 50kg our company is 40% ceramide, 150L dehydrated alcohol is added to be uniformly dispersed；
Step 2: taking 200kg hydroxypropyl beta cyclodextrin, 1000L drinking water is added to dissolve；
Step 3: opening colloid mill, hydroxypropyl beta cyclodextrin aqueous solution is added, a kind of liquid of step is slowly added to, after adding
Equipment is run 20 minutes；
Step 4: carrying out concentration and recovery ethyl alcohol to the liquid that step 3 obtains, obtain after condensed cream spray drying for water
Property cosmetics water-soluble ceramide product, the dehydrated alcohol that steams in concentration process is recycled.
Weigh the product of 1g step 4, after 100ml water is added, aqueous solution also clarify it is bright identical with above-described embodiment, often
A product is substantially all equally, is attained by water-soluble effect.
Claims (5)
1. a kind of preparation method of the water-soluble ceramide applied to cosmetics, which comprises the following steps:
Step 1: dehydrated alcohol is added into neural amide products, and it is uniformly dispersed, forms solution one；
Step 2: weighing the hydroxypropyl beta cyclodextrin of certain mass, and it is dissolved in water, forms solution two；
Step 3: solution two is added in colloid mill, colloid mill is opened, solution one is slowly added dropwise into solution two, is formed and is suspended
Liquid, after being added dropwise to complete, colloid mill runs setting time, includes ceramide sufficiently by hydroxypropyl beta cyclodextrin；
Step 4: the liquid that step 3 obtains is concentrated, dehydrated alcohol is removed, surplus materials is dried, is used
In the water-soluble ceramide product of aqueous cosmetic.
2. the preparation method of the water-soluble ceramide according to claim 1 applied to cosmetics, it is characterised in that: step
The volume of dehydrated alcohol is 2-3 times of ceramide small product size in rapid one.
3. the preparation method of the water-soluble ceramide according to claim 2 applied to cosmetics, it is characterised in that: step
The quality of hydroxypropyl beta cyclodextrin is 2-4 times of ceramide product quality in rapid two；The quality of water is added as hydroxypropyl beta ring paste
3-5 times of extract Iuality.
4. the preparation method of the water-soluble ceramide according to claim 3 applied to cosmetics, it is characterised in that: step
Colloid mill operates to 15-30 minutes in rapid three.
5. the preparation method of the water-soluble ceramide according to claim 4 applied to cosmetics, it is characterised in that: dry
Drying method is spray drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910857858.2A CN110496066A (en) | 2019-09-09 | 2019-09-09 | A kind of preparation method of the water-soluble ceramide applied to cosmetics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910857858.2A CN110496066A (en) | 2019-09-09 | 2019-09-09 | A kind of preparation method of the water-soluble ceramide applied to cosmetics |
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| CN110496066A true CN110496066A (en) | 2019-11-26 |
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| CN201910857858.2A Pending CN110496066A (en) | 2019-09-09 | 2019-09-09 | A kind of preparation method of the water-soluble ceramide applied to cosmetics |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300410A (en) * | 2022-02-23 | 2022-11-08 | 广州源燊创生物科技有限公司 | Raw material composition ratio of water-soluble ceramide and production method thereof |
| CN115636766A (en) * | 2022-10-26 | 2023-01-24 | 中科中山药物创新研究院 | Ceramide clathrate compound eutectic crystal and preparation method and application thereof |
Citations (4)
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|---|---|---|---|---|
| KR100787784B1 (en) * | 2006-07-27 | 2007-12-21 | 주식회사 코리아나화장품 | Cosmetic composition for protecting lip comprising granules |
| CN102274145A (en) * | 2011-08-05 | 2011-12-14 | 广东南方洁灵科技实业有限公司 | Composite cyclodextrin clathrate of licorice flavones and ferulic acid and preparation method and applications thereof |
| JP2017042084A (en) * | 2015-08-26 | 2017-03-02 | 株式会社明治 | Composition containing collagen peptide and ceramide and method for producing the same |
| CN107920580A (en) * | 2015-08-26 | 2018-04-17 | 株式会社明治 | Composition and its manufacture method containing collagen peptide and ceramide |
-
2019
- 2019-09-09 CN CN201910857858.2A patent/CN110496066A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100787784B1 (en) * | 2006-07-27 | 2007-12-21 | 주식회사 코리아나화장품 | Cosmetic composition for protecting lip comprising granules |
| CN102274145A (en) * | 2011-08-05 | 2011-12-14 | 广东南方洁灵科技实业有限公司 | Composite cyclodextrin clathrate of licorice flavones and ferulic acid and preparation method and applications thereof |
| JP2017042084A (en) * | 2015-08-26 | 2017-03-02 | 株式会社明治 | Composition containing collagen peptide and ceramide and method for producing the same |
| CN107920580A (en) * | 2015-08-26 | 2018-04-17 | 株式会社明治 | Composition and its manufacture method containing collagen peptide and ceramide |
Non-Patent Citations (3)
| Title |
|---|
| INDERJIT SINGH ET AL: "Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds", 《JOURNAL OF LIPID RESEARCH》 * |
| 刘德培: "《中华医学百科全书 公共卫生学 环境卫生学》", 31 March 2017, 中国协和医科大学出版社 * |
| 吴清等: "《物理药剂学》", 30 November 2018, 中国中医药出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300410A (en) * | 2022-02-23 | 2022-11-08 | 广州源燊创生物科技有限公司 | Raw material composition ratio of water-soluble ceramide and production method thereof |
| CN115636766A (en) * | 2022-10-26 | 2023-01-24 | 中科中山药物创新研究院 | Ceramide clathrate compound eutectic crystal and preparation method and application thereof |
| CN115636766B (en) * | 2022-10-26 | 2024-06-07 | 中科中山药物创新研究院 | Ceramide inclusion compound eutectic, preparation method and application thereof |
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Application publication date: 20191126 |
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