CN110475551A - 使用短链脂肪酸治疗和预防疾病和障碍 - Google Patents

使用短链脂肪酸治疗和预防疾病和障碍 Download PDF

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Publication number
CN110475551A
CN110475551A CN201880021752.2A CN201880021752A CN110475551A CN 110475551 A CN110475551 A CN 110475551A CN 201880021752 A CN201880021752 A CN 201880021752A CN 110475551 A CN110475551 A CN 110475551A
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CN
China
Prior art keywords
acid
composition
scfa
disease
butyrate
Prior art date
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Pending
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CN201880021752.2A
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English (en)
Chinese (zh)
Inventor
埃拉·C·斯佩克特
马克·A·法伊特尔森
阿拉·阿尔祖马尼扬
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Temple Univ School of Medicine
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Temple Univ School of Medicine
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Publication of CN110475551A publication Critical patent/CN110475551A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transplantation (AREA)
CN201880021752.2A 2017-01-27 2018-01-26 使用短链脂肪酸治疗和预防疾病和障碍 Pending CN110475551A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762451192P 2017-01-27 2017-01-27
US62/451,192 2017-01-27
US201762510867P 2017-05-25 2017-05-25
US201762510872P 2017-05-25 2017-05-25
US62/510,867 2017-05-25
US62/510,872 2017-05-25
US201762530371P 2017-07-10 2017-07-10
US62/530,371 2017-07-10
US201762539572P 2017-08-01 2017-08-01
US62/539,572 2017-08-01
US201762588961P 2017-11-21 2017-11-21
US62/588,961 2017-11-21
PCT/US2018/015383 WO2018140687A1 (en) 2017-01-27 2018-01-26 Use of short chain fatty acids for the treatment and prevention of diseases and disorders

Publications (1)

Publication Number Publication Date
CN110475551A true CN110475551A (zh) 2019-11-19

Family

ID=62978768

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880021752.2A Pending CN110475551A (zh) 2017-01-27 2018-01-26 使用短链脂肪酸治疗和预防疾病和障碍

Country Status (5)

Country Link
US (3) US20220142978A1 (https=)
JP (3) JP7161731B2 (https=)
KR (1) KR102646764B1 (https=)
CN (1) CN110475551A (https=)
WO (1) WO2018140687A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111632047A (zh) * 2020-07-27 2020-09-08 上海市中医医院 木犀草素在预防和治疗子宫内膜异位症药物中的应用
CN114767685A (zh) * 2022-04-25 2022-07-22 北京大学第三医院（北京大学第三临床医学院） 四氢叶酸在抑菌或者预防或治疗眼部疾病中的用途
CN116687899A (zh) * 2023-07-10 2023-09-05 河北医科大学第二医院 短链脂肪酸钠盐丁酸钠和丙酸钠组合用药在als治疗中的应用
CN120093748A (zh) * 2025-03-26 2025-06-06 江汉大学 包含异戊酸和仑伐替尼的组合物在制备抗癌药物中的应用

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US10588871B1 (en) 2019-06-28 2020-03-17 Nexzol Pharma, Inc. Transdermal formulation for the treatment of pain and/or inflammation
WO2021216548A1 (en) * 2020-04-21 2021-10-28 University Of Massachusetts Methods and compositions for treatment of age-related macular degeneration
FR3111551B1 (fr) * 2020-06-19 2022-08-26 Oreal Composition gélifiée comprenant un sel d’acide gras à chaîne courte
US20240009154A1 (en) * 2020-08-04 2024-01-11 Temple University-Of The Commonwealth System Of Higher Education Methods and compositions for treating cytokine release syndrome
JP2023549522A (ja) * 2020-11-12 2023-11-27 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション がん予防における短鎖脂肪酸の使用
JP2024518421A (ja) * 2021-05-07 2024-05-01 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム キメラ抗原受容体（ｃａｒ）ｔ細胞治療に関連する血清メタボロミクス
GB202208911D0 (en) * 2022-06-17 2022-08-10 Ravan Bio Limtied Treatments
CN115068457A (zh) * 2022-07-04 2022-09-20 南昌大学第一附属医院 短链脂肪酸在制备治疗急性胰腺炎药物中的应用
WO2024100756A1 (ja) * 2022-11-08 2024-05-16 ミヤリサン製薬株式会社 子宮、卵管および卵巣における炎症の予防および／または治療剤
FR3141616A1 (fr) * 2022-11-09 2024-05-10 Pll Therapeutics Principes actifs et leur utilisation pour rétablir la perméabilité intestinale et/ou prévenir ou lutter contre des maladies multifactorielles
KR20250107214A (ko) * 2022-11-10 2025-07-11 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 간질환 또는 간장애의 치료 또는 예방 방법
WO2024151503A1 (en) * 2023-01-11 2024-07-18 Temple University- Of The Commonwealth System Of Higher Education Treatment of skin disorders with short chain fatty acids
US12102611B2 (en) * 2024-03-25 2024-10-01 Olfactive Biosolutions, LLC Compositions and methods for treating hypertension by modulating endocrine activity
US12226383B1 (en) 2024-04-30 2025-02-18 Velocity Life Sciences, LLC Compositions containing short-chain fatty acid, methods of use, and methods of making thereof

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US4735967A (en) * 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
US20080107646A1 (en) * 2002-04-26 2008-05-08 Yih-Lin Chung Method for ameliorating pruritus
WO2011147585A1 (en) * 2010-05-28 2011-12-01 Lunamed Ag Compositions for use in the treatment of immune diseases, comprising 4 - phenyl -butyric acid and its salts
US20110300238A1 (en) * 2009-02-18 2011-12-08 Rune Eritzland Mixture of inorganic compounds, preparations containing the mixture and use of the mixture
WO2012131069A1 (en) * 2011-03-31 2012-10-04 Proponent Biotech Gmbh Short chain fatty acids and their derivatives for use in treatment immunogenic disorders
CN103037691A (zh) * 2010-04-28 2013-04-10 香港中文大学 用于预防和治疗高眼压症和青光眼的方法和药物
US20160144014A1 (en) * 2013-07-09 2016-05-26 Vedanta Biosciences Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease

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CN103037691A (zh) * 2010-04-28 2013-04-10 香港中文大学 用于预防和治疗高眼压症和青光眼的方法和药物
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WO2012131069A1 (en) * 2011-03-31 2012-10-04 Proponent Biotech Gmbh Short chain fatty acids and their derivatives for use in treatment immunogenic disorders
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111632047A (zh) * 2020-07-27 2020-09-08 上海市中医医院 木犀草素在预防和治疗子宫内膜异位症药物中的应用
CN114767685A (zh) * 2022-04-25 2022-07-22 北京大学第三医院（北京大学第三临床医学院） 四氢叶酸在抑菌或者预防或治疗眼部疾病中的用途
CN114767685B (zh) * 2022-04-25 2023-10-20 北京大学第三医院（北京大学第三临床医学院） 四氢叶酸在抑菌或者预防或治疗眼部疾病中的用途
CN116687899A (zh) * 2023-07-10 2023-09-05 河北医科大学第二医院 短链脂肪酸钠盐丁酸钠和丙酸钠组合用药在als治疗中的应用
CN120093748A (zh) * 2025-03-26 2025-06-06 江汉大学 包含异戊酸和仑伐替尼的组合物在制备抗癌药物中的应用
CN120093748B (zh) * 2025-03-26 2026-02-06 江汉大学 包含异戊酸和仑伐替尼的组合物在制备抗癌药物中的应用

Also Published As

Publication number Publication date
KR20190108144A (ko) 2019-09-23
JP2020505471A (ja) 2020-02-20
JP7688360B2 (ja) 2025-06-04
KR102646764B1 (ko) 2024-03-13
US20250017883A1 (en) 2025-01-16
WO2018140687A1 (en) 2018-08-02
JP7161731B2 (ja) 2022-10-27
US20250099410A1 (en) 2025-03-27
JP2022179617A (ja) 2022-12-02
US20220142978A1 (en) 2022-05-12
JP2025069304A (ja) 2025-04-30

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