CN110464897A - The foundation of the saturating intubation model of uremic rats abdomen - Google Patents
The foundation of the saturating intubation model of uremic rats abdomen Download PDFInfo
- Publication number
- CN110464897A CN110464897A CN201910735044.1A CN201910735044A CN110464897A CN 110464897 A CN110464897 A CN 110464897A CN 201910735044 A CN201910735044 A CN 201910735044A CN 110464897 A CN110464897 A CN 110464897A
- Authority
- CN
- China
- Prior art keywords
- intubation
- peritoneal dialysis
- abdomen
- saturating
- ontology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/285—Catheters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2250/00—Specially adapted for animals
Abstract
The invention belongs to medical instruments fields, and in particular to a kind of foundation of the saturating intubation model of uremic rats abdomen.A kind of peritoneal dialysis intubation is disclosed first comprising the front end of intubation ontology and intubation plug, the intubation plug and the intubation ontology is detachably connected, and is provided with multiple side openings on the back segment of the intubation ontology.A kind of method for building up of saturating intubation model of uremic rats abdomen is also disclosed, this method comprises: by the peritoneal dialysis intubation implantation rat body.The method for building up of the saturating intubation model of uremic rats abdomen disclosed by the invention is by combining rat own characteristic to be designed, and success rate is high, method is simple to operation and preparation cost is low.The saturating intubation model of rat abdomen of foundation can be used for preclinical study, such as the research such as saturating physiology, pathology of abdomen, provides Clinical Basis to capture human chronic's kidney trouble, benefits ten million patient.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of foundation of the saturating intubation model of uremic rats abdomen.
Background technique
Chronic kidney disease (chronic kidney disease, CKD) is at home and abroad all in rise year by year trend in recent years,
End-stage renal disease is the final final result that various kidney troubles carry out sexual development.Clinically, the main treatment method of end-stage renal disease
Have: haemodialysis, peritoneal dialysis and kidney transplant.With the continuous maturation of peritoneal dialysis technology, China has become in the world
The most country of patients undergoing peritoneal dialysis.With the progress of the saturating pipe interconnection technique of abdomen continuously improved and treated, patients undergoing peritoneal dialysis
The similar even better than haemodialysis of prognosis, but CAPD-related peritonitis, especially intestines source property peritonitis, are still that peritonaeum is saturating
The primary complication for analysing patient is the first cause of the saturating technology failure of abdomen and increases admission rate and the death rate.Therefore long-term peritoneal
Dialysis is still faced with lot of challenges.
Currently, abdominal cavity is repeatedly there are factors, peritonaeum and non-physiologic peritoneal dialysis liquid Long Term Contact during peritoneal dialysis
Infection and long-term abdomen can cause the decline of peritoneal membrane function thoroughly, and the important technical problem such as pipe obstruction influences peritoneal dialysis
Effect.Using the process of animal model simulation clinic peritoneal dialysis, in the saturating physiology of research abdomen, pathology and clinicing aspect are played
Important function prompts abdomen through Peritoneal Transport in journey, structure change and local defense mechanism.However the saturating model of rat abdomen is often
There is the phenomenon that establishing failure, common reason includes: that (1) peritoneal dialysis Related peritonitis or tunnel are scorching；(2) pipeline pulls out
Out or bite broken；(3) abdominal wound disunion；(4) dialysis tubing is wrapped up by omentum majus.Therefore in order to be avoided as far as possible due to above original
Thus cause peritoneal dialysis model to establish failure, the characteristics of by combining rat itself, designs a kind of new uremic rats
The saturating intubation model of abdomen has important value.
Summary of the invention
An object of the present invention is to provide a kind of peritoneal dialysis intubation.
The second object of the present invention is to provide a kind of method for building up of saturating intubation model of uremic rats abdomen, solve existing
Method for establishing model in rat easily occur peritonitis or tunnel be scorching, abdomen be intubated thoroughly be easy to be pulled out or bite broken, abdominal wound not
The problems such as healing and abdomen permeable membrane are wrapped up by omentum majus.
Specifically, technical scheme is as follows:
First aspect of the present invention provides a kind of peritoneal dialysis intubation, the peritoneal dialysis intubation include intubation ontology and
It is intubated plug, the front end of the intubation plug and the intubation ontology is detachably connected, and is arranged on the back segment of the intubation ontology
There are multiple side openings.
Preferably, the intubation plug is calparine cap.
It should be appreciated that the intubation plug in the present invention is not limited to calparine cap, those skilled in the art be can choose arbitrarily
Suitable intubation plug completes the present invention.
Preferably, the intubation ontology is cut out obtained using the effective conduit of single intravenous infusion.
Peritoneal dialysis intubation is implanted into abdominal cavity as foreign matter, the phenomenon that omentum majus wraps up abdomen saturating pipe occurs to reduce, the present invention
Intubation ontology is cut out obtained using the effective conduit of single intravenous infusion, and the saturating pipe of heparin cap closure abdomen is made into closed access,
Therefore the phenomenon that it is with certain biocompatibility, can reduce omentum majus package abdomen saturating pipe, effectively lowers the saturating correlation abdomen of abdomen
The generation of film inflammation.
The present invention is provided with multiple side openings on the back segment of intubation ontology, so that injecting and extracting abdomen repeatedly in a short time
The process of transparent liquid is more unobstructed, while avoiding omentum majus package blocking peritoneal dialysis intubation.
Preferably, the side opening is uniformly distributed.
In the preferred embodiment of the present invention, side opening is pricked on the outer wall of intubation ontology by using No. 7 injection needles
Hole obtains.
Preferably, the maximum distance of side opening and the intubation body tip is 1-3cm.
Preferably, it is subcutaneously all provided in the outlet end of the intubation plug and the rear abdominal cavity exit of peritoneal dialysis intubation
It is equipped with terylene set.
It can be not easy to be fixed in rat abdominal cavity to avoid since catheter of transfusion system is smooth by the way that terylene set is arranged, abdomen wound
Mouth disunion, during causing abdomen saturating, intra-abdominal pressure is excessively high, leads to occur the phenomenon of leakage at intubation.
It is furthermore preferred that the inside of the terylene set includes sterile cotton.It is described in a specific embodiment of the invention
Also contain 502 glue in the inside of terylene set.Cotton is adhered into the skin attachement on the saturating conduit of abdomen with rat, causes have local inflammation
Disease, to reach the purpose of abdominal wound healing.
Preferably, the length of the intubation ontology is 10-20cm.The length of the intubation ontology can be according to the height of rat
It is adjusted.In the preferred embodiment of the present invention, the length of the intubation ontology is 15cm.
The second aspect of the present invention discloses a kind of method for building up of saturating intubation model of uremic rats abdomen, comprising: will be upper
In the peritoneal dialysis intubation implantation rat body stated.
Preferably, since rat body flexibility is good, rat, which is easy to grab, stings calparine cap, calparine cap is stung it is bad, or even abdomen
Pipeline is stung bad thoroughly, leads to the extraction of the saturating pipe of abdomen, causes infection.Therefore by peritoneal dialysis intubation from rat abdominal incisions
Do hypodermic tunnel, tunnel exit selection place 0.8-1.5cm immediately below two ear midpoints, fixed peritoneal dialysis is intubated.
Tunnel exit selection is immediately below the two ear midpoints at 1cm in the preferred embodiment of the present invention.
In a specific embodiment of the invention, prone position, back preserved skin, disinfection, In are taken after uremic rats being anaesthetized
The parallel backbone notch of long 1cm is done below former right-hand cutout, single intravenous infusion pipe is cut into the pipe of long 15cm, tube length
It can be adjusted according to rat height, 20 apertures are pricked in leather hose lateral wall with No. 7 syringe needles in end.The abdominal cavity exit skin after the saturating pipe of abdomen
Terylene set is respectively set in lower and calparine cap outlet end.Abdominal cavity exit hypodermic tunnel is done from incision, tunnel goes out with pocket band line
Mouthful selection under two ear midpoints at 1cm, abdomen is managed to porose one end thoroughly and is penetrated from tunnel exit, tunnel guide guidance down toward abdomen
Chamber, pocket tightens opening and abdomen is managed thoroughly, sutures muscle layer and fixed abdomen saturating pipe abdomen saturating pipe calparine cap end Kraft is fixed to tunnel exit
Subcutaneously, suture outlet.It extracts 15ml physiological saline and carries out peritoneal lavage, to determine the pocket ne-leakage of sewing, give within postoperative three days
Antibiotic treatment is given, is intubated and successfully carries out peritoneal dialysis after 1 week.
Third aspect of the present invention discloses above-mentioned peritoneal dialysis intubation or above-mentioned uremic rats abdomen is intubated mould thoroughly
Application of the method for building up of type in medical instruments field.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination, and without departing from structure of the invention
Think of and protection scope.
The invention has the following advantages: can be used for establishing long-term the invention discloses a kind of peritoneal dialysis intubation
The saturating model of rat abdomen, by with disposable transfusion device conduit make by oneself abdomen manage thoroughly, set pipe in rat back, heparin cap closure abdomen is saturating
Pipe is made into closed access, and terylene is placed on that abdominal cavity exit is subcutaneous and calparine cap outlet end, it is ensured that the healing of abdominal incisions subtracts
The phenomenon of leakage during few abdomen is saturating, ensure that the success of model foundation.The saturating intubation model of uremic rats abdomen disclosed by the invention
Method for building up by combining rat own characteristic to be designed, success rate is high, method is simple to operation and preparation cost is low.
The saturating intubation model of rat abdomen of foundation can be used for preclinical study, such as the research such as saturating physiology, pathology of abdomen, slow to capture the mankind
Property kidney trouble provide Clinical Basis, benefit ten million patient.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of peritoneal dialysis intubation in the embodiment of the present invention；
Fig. 2 is the schematic diagram of the saturating intubation model of uremic rats abdomen in the embodiment of the present invention；
In figure: 1- is intubated plug, and 2- is intubated ontology, 3- side opening, 4- terylene set.
Specific embodiment
Technical solution of the present invention is described in detail with reference to the accompanying drawings and examples, but therefore will be not of the invention
It is limited among the embodiment described range.
In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or says according to commodity
Bright book selection.The reagents and materials used in the present invention are commercially available.
Embodiment 1
Present embodiment discloses a kind of peritoneal dialysis intubations, as shown in Figure 1, peritoneal dialysis intubation includes intubation ontology
2 are detachably connected with intubation plug 1, the intubation plug 1 and the front end for being intubated ontology 2, the back segment of the intubation ontology 2
On be provided with multiple side openings 3.
The intubation plug is calparine cap (Guangzhou lily medical science and technology limited liability company).
The maximum distance of side opening and the intubation body tip is 2cm.
It is subcutaneously provided with and washs in the outlet end of the intubation plug 1 and the rear abdominal cavity exit of peritoneal dialysis intubation
Synthetic fibre set 4.The inside of terylene set 4 includes sterile cotton.
Intubation ontology is cut out obtained using the effective conduit (Shanghai Kai Le infusion apparatus factory) of single intravenous infusion.Intubation is originally
The length of body is 15cm.
Present embodiment discloses peritoneal dialysis intubation, can be used for establishing the long-term saturating model of rat abdomen, by with one
Secondary property catheter of transfusion system self-control abdomen is managed thoroughly, sets pipe in rat back, the saturating pipe of heparin cap closure abdomen is made into closed access, terylene set
Be placed in abdominal cavity exit subcutaneously and calparine cap outlet end, it is ensured that the healing of abdominal incisions, reduce abdomen thoroughly during the phenomenon of leakage, guarantor
The success of model foundation is demonstrate,proved.
Embodiment 2
It is specific as follows present embodiment discloses a kind of method for building up of saturating intubation model of uremic rats abdomen:
One, experimental material
Disposable transfusion device conduit (Shanghai Kai Le infusion apparatus factory), (Guangzhou lily medical science and technology share has sterile calparine cap
Limit company), sterile cotton, the disposable 20ml asepsis injector of peritoneal dialysis solution (Guangzhou Baxter Healthcare Ltd.)；Outside
Section's surgical instrument: operating scissors, eye scissors, needle holder, haemostatic clamp, eye scissors, 2-0 operation suture thread, male adult SD rats (on
Western Poole-Bi Kai experimental animal the Co., Ltd in sea, Shanghai, China).
Two, experimental method
All experiments are checked and approved by Fudan University Shanghai medical college's animal care and using the committee.Originally embodiment is adopted with greatly
5/6 nephrectomy legal system of mouse makees uremia model, SPF health male SD rat, 180 ± 20g of weight.After adaptive feeding 1 week, fiber crops
Prone position, back preserved skin are taken after liquor-saturated, disinfection touches the position of left kidney at back, is parallel to the notch of the long 2cm of backbone,
Skin is successively cut, the left kidney of exposure separates peripheral adipose tissue, ligatures kidney with 2-0 suture, becomes purple by red to kidney
Black loosens ligature, kidney after no bleeding with styptic sponge hemostasis by compression respectively from the left and right sides of kidney excision 1/3
It is dirty red is become by aubergine after, restore remaining left kidney, suture muscle layer and skin respectively.After 1 week restores, the right kidney of row is cut entirely
Art, operation prepare ditto, prone position to be taken after anesthesia, back preserved skin, disinfection, the position of kidney on the right side of back touches is done parallel
In the notch of the long 2cm of backbone, skin, the right kidney of exposure are successively cut, the separation kidney base of a fruit directly ligatures the kidney base of a fruit, cuts off right kidney, checks knot
After Zha Chu is without bleeding, muscle layer and skin are sutured.After performing the operation 4 weeks, tail vein takes blood, detects serum creatinine and urea nitrogen.Creatinine
When reaching normal serum creatinine and 2 times of urea nitrogen with urea nitrogen, for the success of uremic rats model foundation.
Prone position, back preserved skin are taken after uremic rats anesthesia, the parallel ridge of long 1cm is done in disinfection below former right-hand cutout
Column notch；It is implanted into peritoneal dialysis intubation described in embodiment 1, specific steps are as follows: abdominal cavity exit is with pocket band line, from incision
Hypodermic tunnel is done, abdomen at 1cm, is managed porose one end thoroughly and penetrated from tunnel exit by tunnel exit selection under two ear midpoints, In
The guidance of tunnel guide is down toward abdominal cavity, and pocket tightens opening and abdomen is managed thoroughly, sutures muscle layer and the fixed saturating pipe calparine cap of the saturating pipe abdomen of abdomen goes out
It is subcutaneous that mouthful end terylene set is fixed to tunnel exit, suture outlet.It extracts 15ml physiological saline and carries out peritoneal lavage, to determine sewing
Pocket ne-leakage, give antibiotic treatment within postoperative three days, be intubated successfully after 1 week carry out peritoneal dialysis (as shown in Figure 2).
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of peritoneal dialysis intubation, which is characterized in that the peritoneal dialysis intubation includes being intubated ontology and intubation plug, described
Intubation plug and the front end of the intubation ontology are detachably connected, and are provided with multiple side openings on the back segment of the intubation ontology.
2. peritoneal dialysis intubation according to claim 1, which is characterized in that the intubation plug is calparine cap.
3. peritoneal dialysis intubation according to claim 1, which is characterized in that the maximum of side opening and the intubation body tip
Distance is 1-3cm.
4. peritoneal dialysis according to claim 1 intubation, which is characterized in that in the outlet end of the intubation plug and described
The rear abdominal cavity exit of peritoneal dialysis intubation is subcutaneously provided with terylene set.
5. peritoneal dialysis intubation according to claim 4, which is characterized in that the inside of the terylene set includes sterile cotton
Flower.
6. peritoneal dialysis intubation according to claim 1, which is characterized in that the intubation ontology is defeated using disposable vein
The conduit of liquid pipe is cut out obtained.
7. peritoneal dialysis intubation according to claim 1, which is characterized in that the length of the intubation ontology is 10-20cm.
8. a kind of method for building up of the saturating intubation model of uremic rats abdomen characterized by comprising claim 1-7 is any
In peritoneal dialysis intubation implantation rat body described in.
9. according to the method described in claim 8, it is characterized in that, peritoneal dialysis intubation is done from rat abdominal incisions
Hypodermic tunnel, tunnel exit selection place 0.8-1.5cm immediately below the two ear midpoints, fixed peritoneal dialysis are intubated.
10. peritoneal dialysis intubation according to claim 1-7 or the described in any item uremias of claim 8-9
Application of the method for building up of the saturating intubation model of rat abdomen in medical instruments field.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910735044.1A CN110464897A (en) | 2019-08-09 | 2019-08-09 | The foundation of the saturating intubation model of uremic rats abdomen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910735044.1A CN110464897A (en) | 2019-08-09 | 2019-08-09 | The foundation of the saturating intubation model of uremic rats abdomen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110464897A true CN110464897A (en) | 2019-11-19 |
Family
ID=68511423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910735044.1A Pending CN110464897A (en) | 2019-08-09 | 2019-08-09 | The foundation of the saturating intubation model of uremic rats abdomen |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110464897A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2041568U (en) * | 1988-11-11 | 1989-07-26 | 济南市第四人民医院 | Branch pipe dialysis tube for peritoneum |
| CN2094995U (en) * | 1991-07-27 | 1992-02-05 | 上海橡胶制品研究所 | Double sleeve type peritoneal dialysis tube |
| CN1156629A (en) * | 1996-02-06 | 1997-08-13 | 彭罗民 | Peritoneal dialysis pipe and punch and punching method thereof |
| CN1199348A (en) * | 1995-10-10 | 1998-11-18 | 甘布罗股份公司 | Catheter, in particular for peritoneal dialysis |
| CN201500207U (en) * | 2009-09-17 | 2010-06-09 | 中南大学 | Peritoneum dialysis conduit for rat and rabbit |
| CN207871212U (en) * | 2017-10-24 | 2018-09-18 | 孙玲 | A kind of anti-clogging peritoneal dialysis catheters |
-
2019
- 2019-08-09 CN CN201910735044.1A patent/CN110464897A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2041568U (en) * | 1988-11-11 | 1989-07-26 | 济南市第四人民医院 | Branch pipe dialysis tube for peritoneum |
| CN2094995U (en) * | 1991-07-27 | 1992-02-05 | 上海橡胶制品研究所 | Double sleeve type peritoneal dialysis tube |
| CN1199348A (en) * | 1995-10-10 | 1998-11-18 | 甘布罗股份公司 | Catheter, in particular for peritoneal dialysis |
| CN1156629A (en) * | 1996-02-06 | 1997-08-13 | 彭罗民 | Peritoneal dialysis pipe and punch and punching method thereof |
| CN201500207U (en) * | 2009-09-17 | 2010-06-09 | 中南大学 | Peritoneum dialysis conduit for rat and rabbit |
| CN207871212U (en) * | 2017-10-24 | 2018-09-18 | 孙玲 | A kind of anti-clogging peritoneal dialysis catheters |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3713441A (en) | Method of using an artery vein shunt applique | |
| CN203354987U (en) | Long-term-retention hematodialysis catheter | |
| CN110464897A (en) | The foundation of the saturating intubation model of uremic rats abdomen | |
| US20100106161A1 (en) | Surgical methods, devices, and kits | |
| CN216358559U (en) | Subcutaneous tunnel expander | |
| CN106215255B (en) | A kind of drainage tube and its application method with puncture needle | |
| CN208678031U (en) | A kind of animal peritoneal dialysis catheter | |
| CN203235071U (en) | Double-direction-circulating combined subcutaneous flushing drainage tube | |
| CN111359035A (en) | Special drainage tube of breast cancer postoperative | |
| CN102327143A (en) | Disposable internal fistula puncture trocar | |
| CN208851541U (en) | A kind of device for exposure surgical field of view in peritoneal dialysis operation | |
| CN215690242U (en) | Double-sleeve negative pressure flushing drainage tube | |
| CN206214484U (en) | A kind of drainage tube with puncture needle | |
| RU2742858C1 (en) | Method of external jugular vein catheterisation for venous blood sampling in rabbits in chronic experiment | |
| CN216877448U (en) | Nested vascular administration device | |
| CN212235451U (en) | Special drainage tube of breast cancer postoperative | |
| US20220305248A1 (en) | Implantable vascular access device | |
| CN208611448U (en) | A kind of peritoneal dialysis branch pipe needle | |
| Zhang et al. | The" Half-Perc" technique using a simple modified metal trocar for peritoneal dialysis catheter placement: results of a 3-year follow-up of 280 patients and a literature review | |
| CN208852110U (en) | Disposable percutaneous peritoneal dialysis catheters set effective sting device | |
| CN216496780U (en) | Improved dialysis remaining needle | |
| CN209437337U (en) | Not damaged body cavity puncture needle and drainage device with the puncture needle | |
| CN201295409Y (en) | Puncturing flow diverter | |
| CN202263035U (en) | Disposal internal fistula puncturing trochar | |
| SU1409233A1 (en) | Method of treatment of acute destructive pancreatitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191119 |
|
| RJ01 | Rejection of invention patent application after publication |