CN110452217B - 用于尼古丁疫苗开发的光学纯半抗原 - Google Patents

用于尼古丁疫苗开发的光学纯半抗原 Download PDF

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Publication number
CN110452217B
CN110452217B CN201910630434.2A CN201910630434A CN110452217B CN 110452217 B CN110452217 B CN 110452217B CN 201910630434 A CN201910630434 A CN 201910630434A CN 110452217 B CN110452217 B CN 110452217B
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China
Prior art keywords
nicotine
hapten
antibodies
formula
vaccine
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Expired - Fee Related
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CN201910630434.2A
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English (en)
Chinese (zh)
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CN110452217A (zh
Inventor
金姆·D·扬达
乔纳森·W·洛克尼尔
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Scripps Research Institute
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Scripps Research Institute
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Publication of CN110452217A publication Critical patent/CN110452217A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201910630434.2A 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原 Expired - Fee Related CN110452217B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462000312P 2014-05-19 2014-05-19
US62/000,312 2014-05-19
PCT/US2015/031583 WO2015179403A1 (en) 2014-05-19 2015-05-19 Enantiopure haptens for nicotine vaccine development
CN201580026158.9A CN106458971A (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Related Parent Applications (1)

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CN201580026158.9A Division CN106458971A (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Publications (2)

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CN110452217A CN110452217A (zh) 2019-11-15
CN110452217B true CN110452217B (zh) 2022-12-27

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CN201910630434.2A Expired - Fee Related CN110452217B (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原
CN201580026158.9A Pending CN106458971A (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

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CN201580026158.9A Pending CN106458971A (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Country Status (8)

Country Link
US (3) US20170107275A1 (https=)
EP (1) EP3145920B1 (https=)
JP (1) JP6564396B2 (https=)
KR (1) KR102435658B1 (https=)
CN (2) CN110452217B (https=)
AU (1) AU2015264325B2 (https=)
CA (1) CA2949667C (https=)
WO (1) WO2015179403A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170107275A1 (en) 2014-05-19 2017-04-20 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
CN118161604B (zh) * 2024-03-25 2025-01-14 海南大学 一种尼古丁蛋白缀合物、其制备方法及在疫苗中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061054A1 (en) * 1998-05-29 1999-12-02 Independent Pharmaceutica Ab Nicotine immunogen
CN102933237A (zh) * 2010-06-04 2013-02-13 辉瑞疫苗有限责任公司 用于预防或治疗烟碱成瘾的缀合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US6232082B1 (en) * 1998-12-01 2001-05-15 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
EP1963308A4 (en) * 2005-11-28 2010-12-15 Nabi Biopharmaceuticals METHOD FOR PRODUCING A NICOTINE HAPTEN
WO2007100755A1 (en) * 2006-02-27 2007-09-07 Nabi Biopharmaceuticals Method for decreasing the toxic effects of nicotine on fetuses in pregnant women
US7820826B2 (en) * 2006-03-29 2010-10-26 North Carolina State University Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives
US20170107275A1 (en) 2014-05-19 2017-04-20 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
US9884114B2 (en) * 2015-06-23 2018-02-06 Arizona Board Of Regents On Behalf Of Arizona State University Methods of rational nicotine hapten design and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061054A1 (en) * 1998-05-29 1999-12-02 Independent Pharmaceutica Ab Nicotine immunogen
CN102933237A (zh) * 2010-06-04 2013-02-13 辉瑞疫苗有限责任公司 用于预防或治疗烟碱成瘾的缀合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice;Pryde et al.;《PLOS ONE》;20131001;第8卷(第10期);1-16 *

Also Published As

Publication number Publication date
CN110452217A (zh) 2019-11-15
KR102435658B1 (ko) 2022-08-23
JP6564396B2 (ja) 2019-08-21
EP3145920A1 (en) 2017-03-29
US20190119363A1 (en) 2019-04-25
US10487141B2 (en) 2019-11-26
CN106458971A (zh) 2017-02-22
JP2017515867A (ja) 2017-06-15
US20170107275A1 (en) 2017-04-20
CA2949667C (en) 2022-05-03
WO2015179403A1 (en) 2015-11-26
AU2015264325A1 (en) 2016-12-01
EP3145920B1 (en) 2019-09-18
US20180086820A1 (en) 2018-03-29
CA2949667A1 (en) 2015-11-26
KR20170007810A (ko) 2017-01-20
EP3145920A4 (en) 2017-12-27
AU2015264325B2 (en) 2019-02-14

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Granted publication date: 20221227