CA2949667C - Enantiopure haptens for nicotine vaccine development - Google Patents

Enantiopure haptens for nicotine vaccine development Download PDF

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Publication number
CA2949667C
CA2949667C CA2949667A CA2949667A CA2949667C CA 2949667 C CA2949667 C CA 2949667C CA 2949667 A CA2949667 A CA 2949667A CA 2949667 A CA2949667 A CA 2949667A CA 2949667 C CA2949667 C CA 2949667C
Authority
CA
Canada
Prior art keywords
nicotine
hapten
antibodies
vaccine
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2949667A
Other languages
English (en)
French (fr)
Other versions
CA2949667A1 (en
Inventor
Kim D. Janda
Jonathan W. LOCKNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of CA2949667A1 publication Critical patent/CA2949667A1/en
Application granted granted Critical
Publication of CA2949667C publication Critical patent/CA2949667C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2949667A 2014-05-19 2015-05-19 Enantiopure haptens for nicotine vaccine development Active CA2949667C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462000312P 2014-05-19 2014-05-19
US62/000,312 2014-05-19
PCT/US2015/031583 WO2015179403A1 (en) 2014-05-19 2015-05-19 Enantiopure haptens for nicotine vaccine development

Publications (2)

Publication Number Publication Date
CA2949667A1 CA2949667A1 (en) 2015-11-26
CA2949667C true CA2949667C (en) 2022-05-03

Family

ID=54554631

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2949667A Active CA2949667C (en) 2014-05-19 2015-05-19 Enantiopure haptens for nicotine vaccine development

Country Status (8)

Country Link
US (3) US20170107275A1 (https=)
EP (1) EP3145920B1 (https=)
JP (1) JP6564396B2 (https=)
KR (1) KR102435658B1 (https=)
CN (2) CN110452217B (https=)
AU (1) AU2015264325B2 (https=)
CA (1) CA2949667C (https=)
WO (1) WO2015179403A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170107275A1 (en) 2014-05-19 2017-04-20 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
CN118161604B (zh) * 2024-03-25 2025-01-14 海南大学 一种尼古丁蛋白缀合物、其制备方法及在疫苗中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
SE9801923D0 (sv) * 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
US6232082B1 (en) * 1998-12-01 2001-05-15 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
EP1963308A4 (en) * 2005-11-28 2010-12-15 Nabi Biopharmaceuticals METHOD FOR PRODUCING A NICOTINE HAPTEN
WO2007100755A1 (en) * 2006-02-27 2007-09-07 Nabi Biopharmaceuticals Method for decreasing the toxic effects of nicotine on fetuses in pregnant women
US7820826B2 (en) * 2006-03-29 2010-10-26 North Carolina State University Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives
TWI578997B (zh) * 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
US20170107275A1 (en) 2014-05-19 2017-04-20 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
US9884114B2 (en) * 2015-06-23 2018-02-06 Arizona Board Of Regents On Behalf Of Arizona State University Methods of rational nicotine hapten design and uses thereof

Also Published As

Publication number Publication date
CN110452217A (zh) 2019-11-15
KR102435658B1 (ko) 2022-08-23
JP6564396B2 (ja) 2019-08-21
EP3145920A1 (en) 2017-03-29
CN110452217B (zh) 2022-12-27
US20190119363A1 (en) 2019-04-25
US10487141B2 (en) 2019-11-26
CN106458971A (zh) 2017-02-22
JP2017515867A (ja) 2017-06-15
US20170107275A1 (en) 2017-04-20
WO2015179403A1 (en) 2015-11-26
AU2015264325A1 (en) 2016-12-01
EP3145920B1 (en) 2019-09-18
US20180086820A1 (en) 2018-03-29
CA2949667A1 (en) 2015-11-26
KR20170007810A (ko) 2017-01-20
EP3145920A4 (en) 2017-12-27
AU2015264325B2 (en) 2019-02-14

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200416

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20241120