CN110433365B - Anti-pollution negative pressure of suction-type preparation room of dosing - Google Patents
Anti-pollution negative pressure of suction-type preparation room of dosing Download PDFInfo
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- CN110433365B CN110433365B CN201910560409.1A CN201910560409A CN110433365B CN 110433365 B CN110433365 B CN 110433365B CN 201910560409 A CN201910560409 A CN 201910560409A CN 110433365 B CN110433365 B CN 110433365B
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- laminar flow
- flow forming
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/11—Laminar flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
Abstract
The invention provides an anti-pollution negative-pressure administration chamber for an inhalation preparation, which comprises an administration chamber, two sets of air purification systems, two sets of laminar flow forming areas and an administration area, wherein the two sets of laminar flow forming areas are respectively arranged at two ends of the administration chamber, and the administration area is arranged between the two sets of laminar flow forming areas; the airflow is blown out from one set of laminar flow forming area, passes through the dosing area and is blown out from the other set of laminar flow forming area, and unidirectional airflow is formed in the dosing area; the two sets of laminar flow forming areas are respectively provided with a heating temperature adjusting plate and a refrigerating temperature adjusting plate. The invention realizes the purpose of providing pure airflow in a single direction in the administration chamber by the arrangement of two sets of laminar flow forming areas; by arranging a matrix blowing structure consisting of a plurality of laminar flow units in the two sets of laminar flow forming areas, environments with different laminar flow speeds and different temperature requirements are realized; through setting up the pressure buffer room, avoid the human body of laboratory staff to negative pressure adaptability, mutually support with two sets of laminar flow formation districts simultaneously, realize the invariable pressure of dosing room.
Description
Technical Field
The invention relates to the technical field of drug delivery environments in medical clinical tests, in particular to an anti-pollution negative-pressure administration chamber for an inhalation preparation.
Background
When the pharmacokinetics or bioequivalence research is carried out on the inhalation new drug, a certain number of human groups need to be administrated, due to the special administration mode of the inhalation preparation, a part of the drug remains in the air after the administration, and the drug remaining in the air is inhaled by other human groups to generate cross contamination, so that the research result is inaccurate; meanwhile, the nasal spray in the inhalation medicine has higher requirements on the temperature and the humidity of the environment during administration, and the fluctuation of the temperature and the humidity can greatly influence the absorption of the nasal mucosa of a subject to the liquid medicine.
Therefore, a negative pressure administration room is generally needed to solve the above problems, but the existing negative pressure administration room can provide a negative pressure environment, but cannot provide pure airflow in a single direction, so that the risk of drug cross infection of laboratory personnel cannot be avoided; meanwhile, the negative pressure administration room can provide a stable environment with adjustable temperature and humidity, so that different drug experiments can be met.
Disclosure of Invention
In view of the current situation, the invention provides an anti-pollution negative-pressure administration chamber for an inhalation preparation, which can provide pure airflow in a single direction, thereby avoiding cross infection of medicines of laboratory staff.
The invention content of the invention is as follows: an anti-pollution negative pressure administration chamber for an inhalation preparation comprises an administration chamber, two sets of air purification systems, two sets of laminar flow forming areas and an administration area, wherein the two sets of laminar flow forming areas are respectively arranged at two ends of the administration chamber and are symmetrically distributed; the inlet of the dosing chamber is provided with a pressure buffer chamber, and airflow is blown out from one set of laminar flow forming area, passes through the dosing area and then is blown out from the other set of laminar flow forming area to form unidirectional airflow in the dosing area; the two sets of laminar flow forming areas are respectively provided with a heating temperature adjusting plate and a refrigerating temperature adjusting plate, when the required drug administration test temperature is lower than the room temperature, the laminar flow forming area provided with the refrigerating temperature adjusting plate works, and the airflow direction is blown to the laminar flow forming area provided with the heating temperature adjusting plate from the laminar flow forming area provided with the refrigerating temperature adjusting plate; when the required drug administration test temperature is higher than the room temperature, the laminar flow forming area provided with the heating temperature adjusting plate works, and the airflow direction is blown to the laminar flow forming area provided with the refrigerating temperature adjusting plate from the laminar flow forming area provided with the heating temperature adjusting plate; the drug delivery area comprises a plurality of linearly arranged seats, and a plurality of atomization drug delivery devices are arranged on two sides of each seat in parallel; the laminar flow forming area is formed by distributing a plurality of laminar flow units in a matrix form, and the laminar flow units have two working modes, namely, the laminar flow units work independently, and the laminar flow units are combined randomly to form single air flow in a specific area and a direction of the administration area; and a control system is also arranged in the dosing chamber.
Furthermore, the front side and the rear side of the administration chamber are respectively provided with a sealing window.
Furthermore, sealing doors are respectively arranged on the outer side of the pressure buffer chamber and the side communicated with the administration chamber.
Further, the two sets of air purification systems are respectively a first air purification system and a second air purification system, the two sets of laminar flow forming areas are respectively a first laminar flow forming area and a second laminar flow forming area, the first air purification system is communicated with the first laminar flow forming area, and the second air purification system is communicated with the second laminar flow forming area.
Further, the seat arrangement direction is perpendicular to the direction of the air flow in the administration room.
Furthermore, the first laminar flow area and the second laminar flow area are respectively communicated with one end of one control pipeline, and the other ends of the two control pipelines are communicated with the pressure buffer chamber.
Furthermore, one side of the control pipeline, which is close to the pressure buffer chamber, is provided with an electric control valve.
Furthermore, the laminar flow forming area is formed by distributing a plurality of laminar flow units in a matrix form.
Further, the laminar flow unit include integrated chamber, gaseous electric valve, a plurality of honeycomb duct, the integrated chamber front side be provided with a plurality of honeycomb ducts, honeycomb duct and integrated chamber ball pivot installation, and communicate with integrated intracavity portion mutually, the integrated chamber opposite side is provided with gaseous electric valve, gaseous electric valve and honeycomb duct between be provided with the vortex ball, vortex ball and honeycomb duct between be provided with the temperature regulating plate.
Furthermore, the temperature adjusting plate is a heating temperature adjusting plate or a refrigerating temperature adjusting plate.
Further, a gas flowmeter is further arranged between the gas electric valve and the integrated cavity, and laminar flow environments with different flow rates are formed in different areas of the dosing area under the matching of the gas flowmeter, the control system and the gas electric valve.
After the invention adopts the above invention contents, the following advantages are provided:
(1) the purpose of providing pure airflow in a single direction in the dosing chamber is achieved through the arrangement of two sets of laminar flow forming areas;
(2) by arranging a matrix blowing structure consisting of a plurality of laminar flow units in the two sets of laminar flow forming areas, environments with different laminar flow speeds and different temperature requirements are realized;
(3) through setting up the pressure buffer room, avoid the human body of laboratory staff to negative pressure adaptability, mutually support with two sets of laminar flow formation districts simultaneously, realize the invariable pressure of dosing room.
Drawings
Fig. 1 and 2 are schematic overall three-dimensional structures of the present invention.
Fig. 3 is a perspective view of the top of the administration chamber of the present invention with a portion broken away.
Fig. 4 is an assembled perspective view of a part of the components of the present invention.
Fig. 5 is a front view of the internal structure of the dosing chamber of the present invention.
Fig. 6 is an assembled perspective view of a laminar flow forming section according to the present invention.
Fig. 7 is an assembled perspective view of the laminar flow unit according to the present invention.
Fig. 8 and 9 are partially assembled perspective views of the laminar flow unit according to the present invention.
Reference numerals: 1-a dosing chamber; 2-a pressure buffer chamber; 3-a first air purification system; 4-a second air purification system; 5-sealing the window; 6-control the pipeline; 7-a sealing door; 8-an electrically controlled valve; 9-a first laminar flow forming zone; 10-a second laminar flow forming zone; 11-an aerosolized delivery device; 12-a seat; 13-an integrated cavity; 14-gas electric valve; 15-a flow guide pipe; 16-a turbulent ball; 17-temperature adjusting plate; 18-control screen.
Detailed Description
The present invention will be further described with reference to specific examples, which are illustrative of the invention and are not to be construed as limiting the invention.
The first embodiment is as follows: the anti-pollution negative-pressure administration chamber for the inhalation preparations as shown in the figures 1 to 9 mainly comprises an administration chamber 1, the space size of the administration chamber 1 is determined according to the number of experimental medicines and the maximum experimental number of each experiment, starting from the experimental accuracy, the whole administration chamber 1 is a closed environment, sealing windows 5 are respectively arranged at the front side and the rear side of the administration chamber, the sealing windows 5 are only opened during non-experimental periods, and when the sealing windows are closed, the sealing windows 5 can play a good sealing role. Meanwhile, a pressure buffer chamber 2 is arranged at an inlet of the dosing chamber 1, the pressure buffer chamber 2 is used as a pressure buffer area and is also the only channel entering the dosing chamber 1, control pipelines 6 are arranged between the pressure buffer chamber 2 and the two sets of laminar flow forming areas, and each control pipeline 6 is provided with an electric control valve 8 for controlling the pipeline 6 to close and close the pressure buffer chamber 2. In order to ensure good sealing performance of the dosing chamber 1, the pressure buffering chamber 2 is provided with a two-way door structure, a first sealing door 7 is arranged on the outer side of the pressure buffering chamber, and another sealing door 7 is arranged on one side, adjacent to the dosing chamber 1, of the pressure buffering chamber 2, so that the sealing effect of the dosing chamber 7 is improved.
Set up one set of laminar flow formation district respectively at the both ends of dosing room 1, be located the left and right sides of pressure buffer room 2 promptly, the laminar flow formation district that is located the left side of pressure buffer room 2 is first laminar flow formation district, and the laminar flow formation district that is located the right side of pressure buffer room 2 is second laminar flow formation district, and the difference in first laminar flow formation district and second laminar flow formation district lies in, is provided with the heating temperature regulation board in the first laminar flow formation district, and second laminar flow formation district is provided with the refrigeration temperature regulation board. The two sets of air purification systems are respectively provided with a temperature regulating device, and the first air purification system communicated with the first laminar flow forming area is provided with a heating device and is connected with a heating temperature regulating plate in the first laminar flow forming area; the second air purification system communicated with the second laminar flow forming area is provided with a refrigerating device, such as an air compressor, and is connected with a refrigerating and temperature-adjusting plate in the second laminar flow forming area. The two sets of laminar flow forming areas are provided with medicine feeding areas, and an experimenter can enter the medicine feeding areas after entering the medicine feeding room 1 through the pressure buffer room 2, in the embodiment, the temperature of a medicine feeding experiment is higher than the room temperature of the medicine feeding room 1, so that a heating device in a first air purification system is started through a control system, a heating temperature adjusting plate in a first laminar flow forming area works, meanwhile, a unidirectional air flow direction formed in the medicine feeding room 1 is blown from the first laminar flow forming area to a second laminar flow forming area, the experimenter sits on a seat 12 and faces the first laminar flow forming area, and the medicine is fed through an atomization medicine feeding device 11 positioned between the first laminar flow forming area and the seat 12, the atomization medicine feeding device 11 is provided with an automatic medicine spraying device, after the experimenter adjusts to a proper position through the height-adjustable seat 12 according to the height of the experimenter, the atomization medicine feeding device 11 in front of the experimenter starts an automatic medicine spraying function, the experimental medicine can be sprayed to the experimenters.
Each set of laminar flow formation district all is the matrix by a plurality of laminar flow units and distributes and constitute, each laminar flow unit both can independent work promptly, also can make up at will simultaneously, specific area and the direction in the district of dosing form single air current, particularly, be provided with PLC automatic control module among the control system, and temperature monitoring sensor and humidity detection sensor, the flow of the gas flowmeter in every laminar flow unit of control system real-time supervision through giving medicine room 1, adjust the gas flow that different laminar flow units got into gaseous electric valve 14 as required, thereby realize the laminar flow environment of the different velocity of flow in specific area.
In this embodiment, the first air purification system adjusts the humidity of the outputted air according to the temperature monitoring sensor and the humidity detection sensor arranged in the dosing room 1, so that the humidity meets the dosing experiment conditions, and after the purified air is inputted into the first laminar flow area, the air enters the integration cavity 13 through the electric gas valve 14 in each laminar flow unit, and when entering the integration cavity 13, the air is firstly scattered through the turbulent flow ball 16, so as to uniformly pass through the heating temperature adjustment plate, the heating temperature adjustment plate is provided with the air holes and the temperature monitoring sensor, the temperature of the air passing through the temperature monitoring sensor is monitored in real time through the temperature monitoring sensor, and the numerical value of the air is returned to the control system, so that the purpose of real-time adjustment according to the experiment temperature requirements is achieved. The air that reaches after the experiment required temperature through heating the temperature regulation board finally blows off to the district of dosing through 9 honeycomb ducts 15 of the integrated cavity 13 front side, and every honeycomb duct 15 is installed for the ball pivot with integrated cavity 13 to be provided with micro motor at honeycomb duct 15 tip, can control the contained angle between honeycomb duct 15 and the integrated cavity 13, thereby can satisfy different one-way air current demands. The unidirectional air flow blown out by the first laminar flow forming area passes through the dosing area and then flows back through the laminar flow unit corresponding to the second laminar flow forming area, so that negative pressure is formed in the dosing area, meanwhile, an air pressure monitoring sensor is arranged in the dosing chamber 1, and monitoring data are transmitted to a control system in real time, so that the ventilation volumes of the first laminar flow forming area and the second laminar flow forming area are adjusted, and finally, a set negative pressure value is achieved; the flow direction of the gas in the second laminar flow region is just opposite to that in the first laminar flow region, and finally the gas flowing out of the gas electric valve 14 in the second laminar flow region enters the second air purification system.
Example two: the specific structure and operation principle of the present invention have been explained in detail in the first embodiment, and the second embodiment is different from the first embodiment in describing another operation state of the present invention, when the temperature required in the experiment is lower than the room temperature of the dosing chamber 1, the refrigeration device in the second air purification system in the present invention is activated to operate the refrigeration and temperature adjustment plate in the second laminar flow forming region, and the unidirectional air flow direction formed in the dosing chamber 1 is blown from the second laminar flow forming region to the first laminar flow forming region, and the other embodiments are the same as the first embodiment. The control system that sets up in dosing room 1 in two embodiments is for integrating control system, through setting up PLC automated control module, can carry out the parameterization and set up, specifically, is provided with control screen 18 in pressure buffer room 2 one side, can set for the required value of temperature, humidity, atmospheric pressure earlier before the experiment to realize the automatic adjustment of environment in dosing room 1 through the temperature monitoring sensor, humidity detection sensor and the atmospheric pressure monitoring sensor that set up.
Claims (1)
1. The utility model provides an anti-pollution negative pressure dosing chamber of suction-type preparation, includes dosing chamber (1), two sets of air purification system and two sets of laminar flows formation district, dosing district, its characterized in that: the two sets of laminar flow forming areas are respectively arranged at two ends of the dosing chamber (1) and are symmetrically distributed, each set of laminar flow forming area is respectively communicated with one set of air purification system, and the dosing area is arranged between the two sets of laminar flow forming areas; the inlet of the dosing chamber (1) is provided with a pressure buffer chamber (2), air flow is blown out from one set of laminar flow forming area, passes through the dosing area and then is blown out from the other set of laminar flow forming area, and unidirectional air flow is formed in the dosing area; the two sets of laminar flow forming areas are respectively provided with a heating temperature adjusting plate and a refrigerating temperature adjusting plate, when the required drug administration test temperature is lower than the room temperature, the laminar flow forming area provided with the refrigerating temperature adjusting plate works, and the airflow direction is blown to the laminar flow forming area provided with the heating temperature adjusting plate from the laminar flow forming area provided with the refrigerating temperature adjusting plate; when the required drug administration test temperature is higher than the room temperature, the laminar flow forming area provided with the heating temperature adjusting plate works, and the airflow direction is blown to the laminar flow forming area provided with the refrigerating temperature adjusting plate from the laminar flow forming area provided with the heating temperature adjusting plate; the administration area comprises a plurality of seats (12) which are linearly arranged, and a plurality of atomization administration devices (11) are arranged on two sides of each seat (12) in parallel; the laminar flow forming area is formed by distributing a plurality of laminar flow units in a matrix form, and the laminar flow units have two working modes, namely, the laminar flow units work independently, and the laminar flow units are combined randomly to form single air flow in a specific area and a direction of the administration area; the drug delivery chamber is also internally provided with a control system;
the front side and the rear side of the dosing chamber (1) are respectively provided with a sealing window (5); the outer side of the pressure buffer chamber (2) and one side communicated with the dosing chamber (1) are respectively provided with a sealing door (7); the two sets of air purification systems are respectively a first air purification system (3) and a second air purification system (4), the two sets of laminar flow forming areas are respectively a first laminar flow forming area (9) and a second laminar flow forming area (10), the first air purification system (3) is communicated with the first laminar flow forming area (9), and the second air purification system (4) is communicated with the second laminar flow forming area (10);
the arrangement direction of the seat (12) is vertical to the direction of the air flow in the dosing chamber (1); the first laminar flow area and the second laminar flow area are respectively communicated with one end of one control pipeline (6), and the other ends of the two control pipelines (6) are communicated with the pressure buffer chamber (2);
one side of the control pipeline (6) close to the pressure buffer chamber (2) is provided with an electric control valve (8); the laminar flow unit comprises an integrated cavity (13), a gas electric valve (14) and a plurality of flow guide pipes (15), wherein the front side of the integrated cavity (13) is provided with the plurality of flow guide pipes (15), the flow guide pipes (15) are mounted with the integrated cavity (13) in a spherical hinge mode and communicated with the inside of the integrated cavity (13), the other side of the integrated cavity (13) is provided with the gas electric valve (14), a turbulent flow ball (16) is arranged between the gas electric valve (14) and the flow guide pipes (15), and a temperature adjusting plate (17) is arranged between the turbulent flow ball (16) and the flow guide pipes (15); the temperature adjusting plate (17) is a heating temperature adjusting plate or a refrigerating temperature adjusting plate; and a gas flowmeter is further arranged between the gas electric valve (14) and the integrated cavity (13), and a laminar flow environment with different flow rates is formed in different areas of the administration area under the cooperation of the gas flowmeter, the control system and the gas electric valve (14).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910560409.1A CN110433365B (en) | 2019-06-26 | 2019-06-26 | Anti-pollution negative pressure of suction-type preparation room of dosing |
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| CN201910560409.1A CN110433365B (en) | 2019-06-26 | 2019-06-26 | Anti-pollution negative pressure of suction-type preparation room of dosing |
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| CN110433365A CN110433365A (en) | 2019-11-12 |
| CN110433365B true CN110433365B (en) | 2022-02-22 |
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| US2745602A (en) * | 1955-03-16 | 1956-05-15 | William L Hand | Automatic air regulating control device |
| JP2001065491A (en) * | 1999-08-27 | 2001-03-16 | Mitsubishi Electric Corp | Air blower, air conditiner, and air supplying method of the air blower |
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