CN219126860U - Drug administration device and animal experiment system - Google Patents

Abstract

The application relates to a dosing device and animal experiment system, dosing device includes: a first drug delivery mechanism comprising a first drive member for delivering liquid drug to a first outlet; the second dosing mechanism comprises an atomization assembly, a second driving piece and a second outlet, wherein the atomization assembly is used for atomizing liquid and/or solid medicines into gaseous medicines, the second driving piece is communicated with the atomization assembly, and the second driving piece is used for conveying the gaseous medicines generated by the atomization assembly to the second outlet. The first drug delivery mechanism can deliver liquid drugs to the first outlet, and the second drug delivery mechanism can deliver gaseous drugs to the second outlet, so that one drug delivery device can output liquid drugs and/or gaseous drugs so as to meet the diversified test of experimental subjects; in addition, the experimental tests of the liquid medicine and the gaseous medicine can be carried out simultaneously, so that the experimental test efficiency is improved.

Description

Drug administration device and animal experiment system

Technical Field

The embodiment of the application relates to the technical field of experimental equipment, in particular to a drug administration device and an animal experiment system.

Background

The conventional drug administration device is usually aerosol drug administration, that is, a drug is atomized into a gaseous drug by an atomization device, and then the gaseous drug is transferred into a closed space in which a subject is accommodated, so as to obtain experimental data. However, the test of the drug delivery device is single, so that the test is difficult to meet the diversified test of an experimental object, and when the experimental test is required to be performed by using drugs in different forms, different drug delivery devices are required to be adopted, so that the test efficiency is low.

Disclosure of Invention

The application aims at providing a drug administration device and an animal experiment system to realize the diversified test of the drug administration device, improve test efficiency.

In a first aspect of the present application, a drug delivery device is presented, comprising:

a first drug delivery mechanism comprising a first drive member for delivering liquid drug to a first outlet;

the second dosing mechanism comprises an atomization assembly, a second driving piece and a second outlet, wherein the atomization assembly is used for atomizing liquid and/or solid medicines into gaseous medicines, the second driving piece is communicated with the atomization assembly, and the second driving piece is used for conveying the gaseous medicines generated by the atomization assembly to the second outlet.

In some embodiments, the aerosolization assembly includes an aerosolization member and a receiving cavity for receiving a liquid medicament, the aerosolization member for aerosolizing the liquid medicament of the receiving cavity into a gaseous medicament.

In some embodiments, the drug delivery device further comprises a drug reservoir for storing liquid drug, the first drive member being in communication with the drug reservoir, the first drive member being for delivering liquid drug in the drug reservoir to the first outlet.

In some embodiments, the drug delivery device further comprises a housing enclosing the receiving cavity;

the first driving piece is accommodated in the accommodating cavity and is communicated with the medicine storage box outside the shell through a first pipeline;

the second driving piece is accommodated in the accommodating cavity and is communicated with the atomization assembly outside the shell through a second pipeline.

In some embodiments, the first outlet and the second outlet are both open on the housing, the first driving member is in communication with the first outlet through a third conduit, and the second driving member is in communication with the second outlet through a fourth conduit.

In some embodiments, the drug delivery device further comprises a fifth conduit communicating with the first outlet outside the housing and a sixth conduit communicating with the second outlet outside the housing.

In some embodiments, the housing comprises a first side wall and a second side wall arranged opposite to each other, the first side wall is provided with a mounting position, the medicine storage box and the atomizing assembly are mounted at the mounting position, and the first outlet and the second outlet are both arranged on the second side wall.

In some embodiments, the drug delivery device further comprises a first flow controller and a second flow controller;

the first flow controller is used for controlling the flow rate of the liquid medicine delivered to the first outlet;

the second flow controller is for controlling the flow of gaseous medicament delivered to the second outlet.

In some embodiments, the drug delivery device further comprises a control system in signal communication with the first drive member, the second drive member, the atomizing assembly, the first flow controller, and the second flow controller, the control system for controlling the rate of administration, the time of administration, the amount of administration, and the frequency of administration of the first and second drug delivery mechanisms.

In a second aspect, the present application also provides an animal experiment system comprising a drug delivery device according to any one of the embodiments described above, and a housing, a sampling mechanism and an inductor. The box encloses and closes the appearance chamber that is used for acceping experimental animals, the first export of dosing unit with the second export all with hold the chamber intercommunication, sampling mechanism with hold the chamber intercommunication, be used for detecting hold the gaseous state medicine concentration in the chamber. The sensor is arranged in the containing cavity, the sensor is in signal connection with the control system, and when the sensor is triggered, the control system controls the first drug delivery mechanism to deliver liquid drugs to the containing cavity and/or controls the second drug delivery mechanism to deliver gaseous drugs to the containing cavity.

The beneficial effects of the embodiment of the application are that:

in the embodiment of the application, the first drug delivery mechanism can deliver the liquid drug to the first outlet, and the second drug delivery mechanism can deliver the gaseous drug to the second outlet, so that one drug delivery device can deliver the liquid drug and/or the gaseous drug, and the diversified test of experimental subjects can be met. In addition, the experimental tests of the liquid medicine and the gaseous medicine can be carried out simultaneously, so that the experimental test efficiency is improved.

The foregoing description is only an overview of the technical solutions of the present application, and may be implemented according to the content of the specification in order to make the technical means of the present application more clearly understood, and in order to make the above-mentioned and other objects, features and advantages of the present application more clearly understood, the following detailed description of the present application will be given.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and that other drawings may be obtained according to the drawings for a person having ordinary skill in the art.

FIG. 1 is a schematic illustration of a configuration of a drug delivery device according to some embodiments of the present application;

fig. 2 is a schematic structural view of a drug delivery device according to some embodiments of the present application;

FIG. 3 is a schematic illustration of the structure of a drug delivery device according to some embodiments of the present application;

fig. 4 is a schematic structural view of a drug delivery device according to some embodiments of the present application;

fig. 5 is a schematic structural view of a drug delivery device according to some embodiments of the present application;

fig. 6 is a schematic structural diagram of an animal experiment system according to some embodiments of the present application.

Reference numerals illustrate:

1000. an animal experiment system;

100. a drug delivery device;

10. a first drug delivery mechanism; 11. a first driving member; 12. a first outlet; 13. a first pipe; 14. a fifth pipe; 15. a first flow controller;

20. a second drug delivery mechanism; 21. an atomizing assembly; 22. a second driving member; 23. a second outlet; 24. a fourth conduit; 25. a sixth conduit; 26. a second flow controller;

30. a medicine storage box;

40. a housing; 41. a receiving chamber; 42. a first sidewall; 43. a second sidewall;

200. a case; 210. a cavity;

300. a sampling mechanism; 310. a sampler; 320. a fourth flow controller; 330. a sampling tube; 340. a switch;

400. an inductor;

500. and an air inlet pipe.

Detailed Description

In order to facilitate an understanding of the present application, the present application will be described in more detail below with reference to the accompanying drawings and specific examples. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or one or more intervening elements may be present therebetween. The terms "upper", "lower", "left", "right" and the like are used in this specification for illustrative purposes only.

In the description of the embodiments of the present application, the technical terms "first," "second," etc. are used merely to distinguish between different objects and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, a particular order or a primary or secondary relationship.

In the description of the embodiments of the present application, the term "and/or" is merely an association relationship describing an association object, which means that three relationships may exist, for example, a and/or B may mean: a exists alone, A and B exist together, and B exists alone. In addition, the character "/" herein generally indicates that the front and rear associated objects are an "or" relationship.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. In addition, the technical features described below in the different embodiments of the present application may be combined with each other as long as they do not collide with each other.

In a first aspect, the present application proposes a drug delivery device 100, please refer to fig. 1, the drug delivery device 100 comprising a first drug delivery mechanism 10 and a second drug delivery mechanism 20, wherein the first drug delivery mechanism 10 and the second drug delivery mechanism 20 can be used for delivering drugs of different morphologies; for example, the first drug delivery mechanism 10 delivers liquid drug and the second drug delivery mechanism 20 delivers gaseous drug; or the first delivery mechanism 10 delivers a gaseous medicament and the second delivery mechanism 20 delivers a liquid medicament. It will be appreciated that in other embodiments, two drug delivery mechanisms may simultaneously deliver the same type of drug, e.g., different types of drugs in the same shape, to accommodate the variety of drug delivery by drug delivery device 100. It should be noted that, in the embodiments of the present application, the gaseous medicine is not limited to a gaseous state, and the gaseous medicine may be in a state of atomized droplets flowing with air, or in a solid state (e.g., aerosol) flowing with air.

For the first drug delivery mechanism 10, referring to fig. 1 and 2, the first drug delivery mechanism 10 includes a first driving member 11 and a first outlet 12, and the first driving member 11 is in communication with the first outlet 12. The first driver 11 may employ a liquid pump which communicates with a reservoir storing liquid medicament to pump liquid medicament to the first outlet 12. For example, the drug delivery device 100 further comprises a drug storage tank 30, the drug storage tank 30 for storing liquid drug. The first driver 11 communicates with the drug reservoir 30 via the first conduit 13, which allows the first driver 11 to deliver liquid drug to the first outlet 12, thereby giving liquid drug for subsequent experimental testing of the liquid drug.

For the second drug delivery mechanism 20 described above, referring to fig. 1 and 2, the second drug delivery mechanism 20 may be used to deliver a gaseous drug, for example, the second drug delivery mechanism 20 includes an atomizing assembly 21, a second driver 22, and a second outlet 23.

Referring to fig. 2, the atomizing assembly 21 is configured to atomize a liquid and/or solid drug into a gaseous drug, for example, the atomizing assembly 21 includes an atomizing member (not shown) and a receiving chamber (not shown) for receiving the liquid and/or solid drug, and the atomizing member is configured to atomize the liquid and/or solid drug in the receiving chamber into the gaseous drug. The atomizing member includes, but is not limited to, a heating atomizing member, an ultrasonic atomizing member, and the like.

The second driver 22 is in communication with the atomizing assembly 21, the second driver 22 being adapted to deliver gaseous medicament to the second outlet 23. For example, the second driving member 22 employs an air pump which is communicated with the atomizing assembly 21 through a second pipe or directly to suck the gaseous medicine generated by the atomizing assembly 21 to the second outlet 23, thereby giving out the gaseous medicine, so as to facilitate the subsequent experimental test of the gaseous medicine.

In some embodiments, referring to fig. 3, the drug delivery device 100 further includes a housing 40, wherein the housing 40 encloses a housing cavity 41, and the first driving member 11 and the second driving member 22 are both housed in the housing cavity 41, and the housing 40 encloses the housing to protect the first driving member 11 and the second driving member 22. The medicine storage box 30 and the atomization assembly 21 can be arranged outside the shell 40, and when medicine needs to be added into the containing cavity of the medicine storage box 30 or the atomization assembly 21, the containing cavity of the medicine storage box 30 and the containing cavity of the atomization assembly 21 can be opened in the shell 40, so that the medicine can be conveniently added; or directly replace the drug storage tank 30 and the atomizing assembly 21. The first driving member 11 communicates with the medicine storage tank 30 outside the housing 40 through the first pipe 13 to deliver the liquid medicine; the second driver 22 communicates with the atomizing assembly 21 outside the housing 40 via a second conduit to deliver gaseous medicament.

In some embodiments, the first outlet 12 and the second outlet 23 are both formed on the housing 40, and the first driving member 11 is in communication with the first outlet 12 through a third pipe (not labeled in the figure), or is directly in communication with the first outlet 12; the second driver 22 communicates with the second outlet 23 via a fourth conduit 24 or directly with the second outlet 23. Optionally, referring to fig. 4, the housing 40 includes a first side wall 42 and a second side wall 43 that are disposed opposite to each other, the first side wall 42 and the second side wall 43 are disposed opposite to each other, the first side wall 42 is provided with a mounting position (not labeled in the drawing), the medicine storage box 30 and the atomizing assembly 21 are mounted at the mounting position, and the first outlet 12 and the second outlet 23 are both opened at the second side wall 43. The medicine storage tank 30 and the atomizing assembly 21 are both arranged on the same side of the shell 40, so that the medicine storage tank 30 and the atomizing assembly 21 can be conveniently used for simultaneously feeding medicine, and the space occupied by the medicine feeding device 100 in other directions can be reduced.

In other embodiments, referring to fig. 5, the drug delivery device 100 further includes a fifth conduit 14 and a sixth conduit 25, wherein the fifth conduit 14 communicates with the first outlet 12 outside the housing 40, and the sixth conduit 25 communicates with the second outlet 23 outside the housing 40. The fifth and sixth pipes 14 and 25 may be directly communicated with an external test device to perform experimental tests of gaseous and/or liquid drugs.

To control the flow of liquid drug in the fifth conduit 14 and the flow of gaseous drug in the sixth conduit 25, in some embodiments, referring to fig. 5, the administration set 100 further comprises a first flow controller 15 and a second flow controller 26. The first flow controller 15 is used to control the flow of liquid medicament to the first outlet 12 and the second flow controller 26 is used to control the flow of gaseous medicament to the second outlet 23. For example, a first flow controller 15 is provided on the fifth conduit 14 for controlling the flow of liquid drug through the fifth conduit 14. A second flow controller 26 is provided on the sixth conduit 25 for controlling the flow of gaseous medicament through the sixth conduit 25. The first flow controller 15 and the second flow controller 26 may each employ a valve, wherein the valves are respectively located in the fifth pipeline 14 and the sixth pipeline 25, and the valves may be gradually opened and closed to change the flow rate of the liquid medicine flowing through the fifth pipeline 14 and the flow rate of the gaseous medicine flowing through the sixth pipeline 25.

In some embodiments, the administration device 100 further comprises a control system (not shown) mounted to the housing 40 and in signal communication with the first driver 11, the second driver 22, the atomizing assembly 21, the first flow controller 15, and the second flow controller 26 for controlling the administration speed, administration time, administration amount, and administration frequency of the first and second administration mechanisms 10, 20. For example, the control system controls the power output of the first driver 11 and the second driver 22, and when the power output is large, the administration speed is high, whereas the administration speed is low; the control system controls the atomization frequency and the atomization time of the atomization assembly 21, and if the atomization frequency is high and the atomization time is long, the dosage of the second drug delivery mechanism 20 is large; or directly controlling the two flow rates to control the dosage of the two drug delivery mechanisms; the control of the administration time can be directly performed by controlling the running time of the two driving members; the control of the dosing frequency can be achieved by controlling the on-off interval time of the two driving parts or by controlling the on-off interval time of the two flow controllers.

In the present embodiment, the first administration mechanism 10 may deliver liquid medicine to the first outlet 12, and the second administration mechanism 20 may deliver gaseous medicine to the second outlet 23, which may enable one administration device 100 to perform both liquid medicine and/or gaseous medicine output so as to satisfy various tests on subjects. In addition, the experimental tests of the liquid medicine and the gaseous medicine can be carried out simultaneously, so that the experimental test efficiency is improved.

In a second aspect, the present application further provides an animal experiment system 1000, referring to fig. 6, including the drug delivery device 100 according to any of the above embodiments, a case 200, a sampling mechanism 300, and an inductor 400.

The housing 200 encloses a chamber 210, the chamber 210 being configured to house an experimental animal, and the first outlet 12 and the second outlet 23 of the drug delivery device 100 are both in communication with the chamber 210 to deliver liquid and gaseous drugs into the chamber 210. Wherein the second outlet 23 may be connected to an air inlet pipe 500, the air inlet pipe 500 being adapted to allow air to be introduced, which allows the gaseous medicine and the air to be mixed; further, a third flow controller (not shown) is disposed on the air inlet pipe 500, and the air inlet flow of the air inlet pipe 500 can be adjusted by the third flow controller, so as to adjust the concentration of the gaseous medicine entering the cavity 210. The concentration of the liquid drug may be adjusted in advance in the drug reservoir 30.

The concentration of the gaseous medicine can be detected by the sampling mechanism 300, the sampling mechanism 300 can collect the mixed gas flowing through the cavity 210, and the concentration of the aerosol in the mixed gas flowing through the cavity 210 can be calculated by the weight change before and after the sampling mechanism 300 collects in a certain time. For example, sampling mechanism 300 includes a sampler 310, a fourth flow controller 320, a sampling tube 330, and a switch 340. One end of the sampling tube 330 is connected with the case 200, and the other end of the sampling tube 330 is connected with an external negative pressure source. The fourth flow controller 320 is disposed on the sampling tube 330, the switch 340 is disposed on the sampling tube 330, and the switch 340 is located between the fourth flow controller 320 and an external negative pressure source. The sampler 310 is disposed on the sampling tube 330, and the sampler 310 is located between the housing 200 and the fourth flow controller 320. The gas in the chamber 210 is sequentially discharged to the outside through the sampler 310, the fourth flow controller 320, the switch 340, and the external negative pressure source.

The sampler 310 includes a filtering membrane (not shown), and when the mixed gas in the chamber 210 flows through the sampler 310, the experimental gas is filtered by the filtering membrane, and other gases are discharged to the outside through the filtering membrane. According to the gas flow rate of the fourth flow controller 320, the volume of the gas in a certain time can be calculated, the mass of the filtered aerosol can be obtained by weighing the filter membrane, and then the concentration of the aerosol can be calculated.

The sensor 400 is disposed in the cavity 210, and the sensor 400 is in signal connection with a control system, and when the sensor 400 triggers, the control system controls the first administration mechanism 10 to deliver liquid medicine to the cavity 210 and/or controls the second administration mechanism 20 to deliver gaseous medicine to the cavity 210. By arranging the sensor 400, the experimental function of the animal experiment system 1000 can be increased, for example, the dependence of the experimental animal on the medicine and the relation of addiction can be judged by the number of times that the experimental animal triggers the sensor 400 within a certain time. It is understood that the sensor 400 may be an infrared sensor 400, a laser sensor 400, or the like, which is a directly available sensor 400 in the prior art.

It should be noted that the description and drawings of the present application show preferred embodiments of the present application, but the present application may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, which are not to be construed as additional limitations on the content of the present application, but are provided for the purpose of providing a more thorough understanding of the present disclosure. The above-described features are further combined with each other to form various embodiments not listed above, and are considered to be the scope described in the present specification; further, modifications and variations of the present utility model may occur to those skilled in the art in light of the foregoing teachings, and all such modifications and variations are intended to be within the scope of the appended claims.

Claims (10)

1. A drug delivery device, comprising:

a first drug delivery mechanism comprising a first drive member for delivering liquid drug to a first outlet;

the second dosing mechanism comprises an atomization assembly, a second driving piece and a second outlet, wherein the atomization assembly is used for atomizing liquid and/or solid medicines into gaseous medicines, the second driving piece is communicated with the atomization assembly, and the second driving piece is used for conveying the gaseous medicines generated by the atomization assembly to the second outlet.

2. The drug delivery device of claim 1, wherein the aerosolization assembly comprises an aerosolization member and a receiving cavity, the receiving cavity for receiving a liquid medicament, the aerosolization member for aerosolizing the liquid medicament of the receiving cavity into a gaseous medicament.

3. The drug delivery device of claim 1, further comprising a drug reservoir for storing liquid drug, the first driver in communication with the drug reservoir, the first driver for delivering liquid drug in the drug reservoir to the first outlet.

4. The drug delivery device of claim 3, further comprising a housing enclosing the receiving cavity;

the first driving piece is accommodated in the accommodating cavity and is communicated with the medicine storage box outside the shell through a first pipeline;

the second driving piece is accommodated in the accommodating cavity and is communicated with the atomization assembly outside the shell through a second pipeline.

5. The drug delivery device of claim 4, wherein the first outlet and the second outlet are both open on the housing, the first driver is in communication with the first outlet via a third conduit, and the second driver is in communication with the second outlet via a fourth conduit.

6. The drug delivery device of claim 5, further comprising a fifth conduit and a sixth conduit, the fifth conduit communicating with the first outlet outside the housing, the sixth conduit communicating with the second outlet outside the housing.

7. The drug delivery device of claim 4, wherein the housing comprises a first side wall and a second side wall disposed opposite one another, the first side wall being provided with a mounting location, the drug storage tank and the atomizing assembly being mounted to the mounting location, the first outlet and the second outlet both opening into the second side wall.

8. The drug delivery device of claim 1, further comprising a first flow controller and a second flow controller;

the first flow controller is used for controlling the flow rate of the liquid medicine delivered to the first outlet;

the second flow controller is for controlling the flow of gaseous medicament delivered to the second outlet.

9. The drug delivery device of claim 8, further comprising a control system in signal communication with the first drive member, the second drive member, the atomizing assembly, the first flow controller, and the second flow controller, the control system for controlling the rate, time, amount, and frequency of administration of the first and second drug delivery mechanisms.

10. An animal experiment system comprising the drug delivery device according to any one of claims 1 to 9, and a housing, a sampling mechanism and an inductor;

the box body is enclosed with a cavity for accommodating experimental animals;

the first outlet and the second outlet of the drug delivery device are communicated with the containing cavity;

the sampling mechanism is communicated with the containing cavity and is used for detecting the concentration of the gaseous medicine in the containing cavity;

the sensor is arranged in the containing cavity, the sensor is in signal connection with the control system, and when the sensor is triggered, the control system controls the first drug delivery mechanism to deliver liquid drugs to the containing cavity and/or controls the second drug delivery mechanism to deliver gaseous drugs to the containing cavity.

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