CN110433218A - A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian - Google Patents

A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian Download PDF

Info

Publication number
CN110433218A
CN110433218A CN201910905071.9A CN201910905071A CN110433218A CN 110433218 A CN110433218 A CN 110433218A CN 201910905071 A CN201910905071 A CN 201910905071A CN 110433218 A CN110433218 A CN 110433218A
Authority
CN
China
Prior art keywords
parts
berry extract
eliminating dampness
dispelling wind
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910905071.9A
Other languages
Chinese (zh)
Inventor
邱静斌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hunan Aiyu Biological Science & Technology Co Ltd
Original Assignee
Hunan Aiyu Biological Science & Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hunan Aiyu Biological Science & Technology Co Ltd filed Critical Hunan Aiyu Biological Science & Technology Co Ltd
Priority to CN201910905071.9A priority Critical patent/CN110433218A/en
Publication of CN110433218A publication Critical patent/CN110433218A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention proposes a kind of dipping preparations of dispelling wind and eliminating dampness warming and activating meridian, it is prepared by the raw material of following parts by weight: 1-5 parts of folium artemisiae argyi, 0.5-2 parts of lopseed, 0.5-2 parts of lycopodium calvatum, cortex cinnamomi branch 1-3 parts, 1-3 parts of perilla leaf, 1-3 parts of Fructus Liquidambaris berry extract, 1-3 parts of pericarpium zanthoxyli berry extract, 1-3 parts of Rhizoma Chuanxiong root.The present invention is suitble to head, the aching and tired pain of body seen in affection of exogenous wind-cold, and arthritis, wound or apoplexy sequelae are shown in there is muscle, muscles and bones, joint pain, numbness, weighs the even illnesss such as joint stuffiness, it invigorates blood circulation with expelling wind and clearing away cold, dredge the effect through removing obstruction in channels to relieve pain, effect is good, it is at low cost, it has broad application prospects.

Description

A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian.
Background technique
Rheumatism, rheumatoid arthritis are a kind of connective tissue disease, are caused by wind-cold damp pathogen invades human body, generally mostly Illness is arthralgia and dyskinesia.Clinical manifestation is redness and swelling of joints heat pain, and joint hair is stiff from morning, and pain aggravates, even There is dysarthrasis and Joint shift etc., individual joints may be studied carefully complete stiff.Its cause of disease be mainly body experience wind, it is cold, The invasion of damp evil cause poor blood circulation so as to cause symptoms such as limbs joint red and swollen heat pain hair deadlocks.Rheumatism, class wind in recent years The disease incidence of wet arthritis constantly increases, and age of onset is smaller and smaller.Therefore, rheumatism, rheumatoid arthritis are prevented and treated There is great meaning.
Summary of the invention
The present invention provides a kind of dipping preparation and preparation method thereof of dispelling wind and eliminating dampness warming and activating meridian, it is intended that providing A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian is suitble to head seen in affection of exogenous wind-cold, the aching and tired pain of body and arthritis, wound Or apoplexy sequelae is shown in there is muscle, muscles and bones, joint pain, numbness, weighs the even illnesss such as joint stuffiness, has expelling wind and clearing away cold living Blood dredges the effect through removing obstruction in channels to relieve pain, and effect is good, at low cost, has broad application prospects.
The present invention provides a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, is prepared by the raw material of following parts by weight: 1-5 parts of folium artemisiae argyi, 0.5-2 parts of lopseed, 0.5-2 parts of lycopodium calvatum, cortex cinnamomi branch 1-3 parts, 1-3 parts of perilla leaf, Fructus Liquidambaris berry extract 1-3 parts, 1-3 parts of pericarpium zanthoxyli berry extract, 1-3 parts of Rhizoma Chuanxiong root.
As further improvement of the invention, it is prepared by the raw material of following parts by weight: 2.5 parts of folium artemisiae argyi, lopseed 1 Part, 1 part of lycopodium calvatum, cortex cinnamomi branch 1.5 parts, 1.5 parts of perilla leaf, 1.5 parts of Fructus Liquidambaris berry extract, 1.5 parts of pericarpium zanthoxyli berry extract, river 1.5 parts of rhizome of chuanxiong root.
As further improvement of the invention, the Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract are by following methods system It is standby: by raw material drying, to be ground into little particle, with ultramicro crushing treatment after alcohol solution dipping, low temperature drying obtains Ultramicro-powder; Semi-bionic extraction method liquid is added into Ultramicro-powder, after 37 DEG C of extractions 1-2h, enzyme deactivation is cooled to room temperature, and supernatant is collected by centrifugation, decompression Low-temperature evaporation obtains Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract.
As further improvement of the invention, the ethanol solution is the ethanol solution of 75wt%, and the soaking time is 2-5h。
As further improvement of the invention, the power of the ultramicro grinding is 3000W-4000W, drying temperature 40 ℃。
As further improvement of the invention, the semi-bionic extraction method liquid is composed of by weight following raw material: 1 part of 15wt% hydrochloric acid, 20 parts of pepsin, 5 parts of ethyl alcohol, 200 parts of water.
As further improvement of the invention, the enzyme deactivation condition is 105 DEG C of enzyme deactivation 10min.
The present invention further protects a kind of preparation method of the dipping preparation of above-mentioned dispelling wind and eliminating dampness warming and activating meridian, including following Step:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class Chinese herbal medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, respectively Slice storage, it is spare;
S2. all medicinal materials got ready are dried into 3-5h for the first time, then is placed in dryer and is dehydrated, dry built-in temperature Control is 100 DEG C -110 DEG C, and dehydration to water content is 20%-25%, is taken out, and second of sunning 2-3h puts back to dryer again Steam dehydration is inside dried, drying built-in temperature control is 95 DEG C -105 DEG C, and dehydration to water content is 8%-12%;It is placed in dry Dry environment storage is spare;
S3. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend institute It obtains drug and crosses 20-60 mesh, be loaded on medicine bag, and medicine bag is put into microwave 2-3min in micro-wave oven, it is cold that taking-up is placed in dry environment But, it is added Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet, the inner packing medicine bag material is gauze or fiber cloth, then Loaded on being sealed in outer packing to get bath powder.
As further improvement of the invention, the intensity of illumination of the first time sunning is 60000-80000Lux, described The intensity of illumination of second of sunning is 70000-90000Lux.
As further improvement of the invention, the microwave power is 1200-1500W.
Lopseed is sweet in flavor, pungent, warm-natured, can dispelling wind and eliminating dampness, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain;Lycopodium calvatum slight bitter, pungent-warm can dispel Wind, dissipating cold, dehumidification swelling, relaxing tendons and activating collaterals, are used for treating arthralgia due to cold and dampness, muscle arteries and veins contraction pain etc.;Folium artemisiae argyi, purple perilla, ramulus cinnamomi, Fructus Liquidambaris are pungent Warm cold dispelling, promoting blood circulation and removing obstruction in channels, relieving spasm to stop pain;Pericarpium zanthoxyli is longer than warm in pain, and Rhizoma Chuanxiong blood-activating and qi-promoting is longer than treatment intermittent headache pain.All medicines Joint, can not only solve the chill of exogenous disease, and can temperature three-way meridian and dissipate the promoting extremities blood circulation caused by wound, apoplexy it is unsmooth due to The heresy of the cold-dampness of siltation.
The invention has the following beneficial effects: the present invention to obtain the Fructus Liquidambaris of breaking-wall cell using soybean dietary fiber technology Berry extract or pericarpium zanthoxyli berry extract, active constituent recovery rate is high, and low temperature extracts active constituent and is not destroyed, and half bionical liquid mentions It takes and enzymatic hydrolysis acquisition low molecule active constituent is carried out to raw material, the effect of dipping is more preferable;Prior to liquid medicine fumigating when use, steep immediately Bath can heighten the effect of a treatment;
The present invention is suitble to head seen in affection of exogenous wind-cold, the aching and tired pain of body and arthritis, wound or apoplexy sequelae to see there is flesh Meat, joint pain, numbness, weighs the even illnesss such as joint stuffiness at muscles and bones, have expelling wind and clearing away cold promoting blood circulation, dredges and is removed obstruction in channels to relieve pain Effect, effect is good, at low cost, has broad application prospects.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Some embodiments of invention without any creative labor, may be used also for those of ordinary skill in the art To obtain other drawings based on these drawings.
Fig. 1 is the preparation flow figure of the dipping preparation of dispelling wind and eliminating dampness of embodiment of the present invention warming and activating meridian.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
Raw material form (parts by weight): 1 part of folium artemisiae argyi, 0.5 part of lopseed, 0.5 part of lycopodium calvatum, cortex cinnamomi branch 1 part, 1 part of perilla leaf, 1 part of Fructus Liquidambaris berry extract, 1 part of pericarpium zanthoxyli berry extract, 1 part of Rhizoma Chuanxiong root.
Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract are prepared by following methods: by raw material drying, being ground into little particle, used Ultramicro crushing treatment after 75wt% alcohol solution dipping 2h, power 3000W, 40 DEG C of low temperature dryings obtain Ultramicro-powder;To ultra micro Semi-bionic extraction method liquid is added in powder, and (semi-bionic extraction method liquid is composed of by weight following raw material: 1 part of 15wt% hydrochloric acid, stomach 20 parts of protease, 5 parts of ethyl alcohol, 200 parts of water, solid-liquid ratio 1:20), after 37 DEG C of extraction 1h, enzyme deactivation, enzyme deactivation condition is 105 DEG C of enzyme deactivations 10min is cooled to room temperature, and supernatant is collected by centrifugation, and depressurizes low-temperature evaporation, obtains Fructus Liquidambaris berry extract or pericarpium zanthoxyli fruit is extracted Object.
The preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, comprising the following steps:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class Chinese herbal medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, respectively Slice storage, it is spare;
S2. all medicinal materials got ready are dried into 3h, intensity of illumination 60000Lux for the first time, then is placed in dryer and carries out Dehydration, drying built-in temperature control is 100 DEG C, and dehydration to water content is 20%, is taken out, second of sunning 2h, and intensity of illumination is 70000Lux puts back in dryer again and steam dehydration is dried, and drying built-in temperature control is 95 DEG C, dehydration to water content It is 8%;It is spare to be placed in dry environment storage;
S3. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend institute It obtains drug and crosses 20 meshes, be loaded on medicine bag, and medicine bag is put into microwave 2min in micro-wave oven, microwave power 1200W, taking-up is set It is cooling in dry environment, Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet is added, the inner packing medicine bag material is gauze Or fiber cloth, it refills in being sealed in outer packing to get bath powder.
Embodiment 2
Raw material forms (parts by weight): 5 parts of folium artemisiae argyi, 2 parts of lopseed, 2 parts of lycopodium calvatum, cortex cinnamomi branch 3 parts, 3 parts of perilla leaf, Lu Lu Logical 3 parts of berry extract, 3 parts of pericarpium zanthoxyli berry extract, 3 parts of Rhizoma Chuanxiong root.
Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract are prepared by following methods: by raw material drying, being ground into little particle, used Ultramicro crushing treatment after 75wt% alcohol solution dipping 5h, power 4000W, 40 DEG C of low temperature dryings obtain Ultramicro-powder;To ultra micro Semi-bionic extraction method liquid is added in powder, and (semi-bionic extraction method liquid is composed of by weight following raw material: 1 part of 15wt% hydrochloric acid, stomach 20 parts of protease, 5 parts of ethyl alcohol, 200 parts of water, solid-liquid ratio 1:20), after 37 DEG C of extraction 2h, enzyme deactivation, enzyme deactivation condition is 105 DEG C of enzyme deactivations 10min is cooled to room temperature, and supernatant is collected by centrifugation, and depressurizes low-temperature evaporation, obtains Fructus Liquidambaris berry extract or pericarpium zanthoxyli fruit is extracted Object.
The preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, comprising the following steps:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class Chinese herbal medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, respectively Slice storage, it is spare;
S2. all medicinal materials got ready are dried into 5h, intensity of illumination 80000Lux for the first time, then is placed in dryer and carries out Dehydration, drying built-in temperature control is 110 DEG C, and dehydration to water content is 25%, is taken out, second of sunning 3h, and intensity of illumination is 90000Lux puts back in dryer again and steam dehydration is dried, and drying built-in temperature control is 105 DEG C, is dehydrated to aqueous Amount is 12%;It is spare to be placed in dry environment storage;
S3. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend institute It obtains drug and crosses 60 meshes, be loaded on medicine bag, and medicine bag is put into microwave 3min in micro-wave oven, microwave power 1500W, taking-up is set It is cooling in dry environment, Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet is added, the inner packing medicine bag material is gauze Or fiber cloth, it refills in being sealed in outer packing to get bath powder.
Embodiment 3
Raw material forms (parts by weight): 2.5 parts of folium artemisiae argyi, 1 part of lopseed, 1 part of lycopodium calvatum, cortex cinnamomi branch 1.5 parts, perilla leaf 1.5 Part, 1.5 parts of Fructus Liquidambaris berry extract, 1.5 parts of pericarpium zanthoxyli berry extract, 1.5 parts of Rhizoma Chuanxiong root.
Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract are prepared by following methods: by raw material drying, being ground into little particle, used Ultramicro crushing treatment after 75wt% alcohol solution dipping 3h, power 3500W, 40 DEG C of low temperature dryings obtain Ultramicro-powder;To ultra micro Semi-bionic extraction method liquid is added in powder, and (semi-bionic extraction method liquid is composed of by weight following raw material: 1 part of 15wt% hydrochloric acid, stomach 20 parts of protease, 5 parts of ethyl alcohol, 200 parts of water, solid-liquid ratio 1:20), after 37 DEG C of extraction 1.5h, enzyme deactivation, enzyme deactivation condition is 105 DEG C and goes out Enzyme 10min, is cooled to room temperature, and supernatant is collected by centrifugation, and depressurizes low-temperature evaporation, obtains Fructus Liquidambaris berry extract or pericarpium zanthoxyli fruit is extracted Object.
The preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, comprising the following steps:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class Chinese herbal medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, respectively Slice storage, it is spare;
S2. all medicinal materials got ready are dried into 4h, intensity of illumination 70000Lux for the first time, then is placed in dryer and carries out Dehydration, drying built-in temperature control is 105 DEG C, and dehydration to water content is 22%, is taken out, second of sunning 2.5h, intensity of illumination It for 80000Lux, is put back in dryer again and steam dehydration is dried, drying built-in temperature control is 100 DEG C, and dehydration is to containing Water is 10%;It is spare to be placed in dry environment storage;
S3. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend institute It obtains drug and crosses 40 meshes, be loaded on medicine bag, and medicine bag is put into microwave 2.5min in micro-wave oven, microwave power 1350W, take out It is cooling to be placed in dry environment, Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet is added, the inner packing medicine bag material is yarn Cloth or fiber cloth are refilled in being sealed in outer packing to get bath powder.
Comparative example 1
Compared with Example 3, raw material proportioning is different, and raw material forms (parts by weight): 10 parts of folium artemisiae argyi, stretches muscle at 0.1 part of lopseed 0.1 part of grass, cortex cinnamomi branch 0.2 part, 0.2 part of perilla leaf, 0.2 part of Fructus Liquidambaris berry extract, 0.2 part of pericarpium zanthoxyli berry extract, Rhizoma Chuanxiong root 0.2 part.
Comparative example 2
Compared with Example 3, the Extraction technique of Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract is different.
Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract are prepared by following methods: by raw material drying, being ground into little particle, used Ultramicro crushing treatment after 25wt% alcohol solution dipping 1h, power 1000W, 100 DEG C of drying obtain Ultramicro-powder;To Ultramicro-powder (semi-bionic extraction method liquid is composed of middle addition semi-bionic extraction method liquid by weight following raw material: 1 part of 15wt% hydrochloric acid, stomach egg 20 parts of white enzyme, 5 parts of ethyl alcohol, 200 parts of water, solid-liquid ratio 1:100), after 50 DEG C of extraction 1h, enzyme deactivation, enzyme deactivation condition is 105 DEG C of enzyme deactivations 2min is cooled to room temperature, and supernatant is collected by centrifugation, and is depressurized low-temperature evaporation, is obtained Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract.
Comparative example 3
Compared with Example 3, it is not dried.
The preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, comprising the following steps:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class Chinese herbal medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, respectively Slice storage, it is spare;
S2. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend institute It obtains drug and crosses 40 meshes, be loaded on medicine bag, and medicine bag is put into microwave 2.5min in micro-wave oven, microwave power 1350W, take out It is cooling to be placed in dry environment, Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet is added, the inner packing medicine bag material is yarn Cloth or fiber cloth are refilled in being sealed in outer packing to get bath powder.
Comparative example 4
Compared with Example 3, microwave treatment is not carried out.
The preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, comprising the following steps:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class Chinese herbal medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, respectively Slice storage, it is spare;
S2. all medicinal materials got ready are dried into 4h, intensity of illumination 70000Lux for the first time, then is placed in dryer and carries out Dehydration, drying built-in temperature control is 105 DEG C, and dehydration to water content is 22%, is taken out, second of sunning 2.5h, intensity of illumination It for 80000Lux, is put back in dryer again and steam dehydration is dried, drying built-in temperature control is 100 DEG C, and dehydration is to containing Water is 10%;It is spare to be placed in dry environment storage;
S3. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend institute It obtains drug and crosses 40 meshes, be loaded on medicine bag, Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet, the inner packing medicine bag is added Material is gauze or fiber cloth, is refilled in being sealed in outer packing to get bath powder.
Clinical test:
From in May, 2018 to what is gone to a doctor between in May, 2019 to certain institute of traditional Chinese medicine, the various pathologic as caused by wind, cold, wet are closed It saves in the condition subjects such as pain, swelling, stiff, movable difficulty, chooses patient 140 agreed to using medicinal powder of the present invention, averagely It is divided into seven groups.7 groups are randomly divided into, is successively bathed using the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian of the invention, one time a day, Continuous bubble uses January.Test result such as the following table 1.
Table 1
Group It cures (people) Effective (people) Effectively (people) in vain Total effective rate (%)
Embodiment 1 13 6 1 0 100
Embodiment 2 14 5 1 0 100
Embodiment 3 16 4 0 0 100
Comparative example 1 6 2 2 10 50
Comparative example 2 5 6 1 8 60
Comparative example 3 6 4 3 7 65
Comparative example 4 7 4 3 6 70
As seen from the above table, after being bathed using the dipping preparation of the dispelling wind and eliminating dampness warming and activating meridian of 1-3 of embodiment of the present invention preparation Muscle is loosened, and slight illness is eliminated, and total effective rate reaches 100%, and comparative example 1 is consistent with inventive formulation, but matches difference, Effect is obviously not so good as the present invention, it is seen that the proportion of different material medicine is for realizing that the technology of the present invention effect plays an important role;Comparison The preparation technology parameter of Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract is different in example 2, and obtained extract effect is poor, thus Influence the overall effect of preparation;It is not dried when in comparative example 3 prepared by preparation, kills bacterium worm of Chinese herbal medicine etc., cause preparation Shortened shelf life, effective time is shorter, has within head ten days good effect, and later period use causes drug effect to subtract since the shelf-life is not long It is weak, so that total effective rate declines;In comparative example 4 preparation prepare when use microwave treatment, most of worm's ovum, strain spore etc. not by It destroys, causes the shortened shelf life of preparation, there is good effect for head 15 days, due to egg hatch, bacterium worm is broken for later period use It is bad, cause drug effect to weaken, so that total effective rate declines.
Typical case 1
Zhao so-and-so, female, 35 years old;Shoulder aches, joint is without deformation;By the wind, cool, moist to aggravate the pain;Pale tongue, tongue fur is thin white, Veins string.30g is wrapped using medicinal powder 1 every time, is bathed, 1 times a day, using after a week, pain is substantially reduced;Ailing solution completely after 30 days It removes;Can wind-engaging, it is cool.It is further continued for using being discontinued after 30 days, without recurrence, recovery from illness after January of being discontinued.
Typical case 2
Mr. Wang, male 32 years old, suffers from ankylosing spondylitis.Because back is stiff with extremities joint pain before 3 years, X piece is shown: double Sacro-iliac joint gap is fuzzy, and articular surface has the cryptomere to differ in size destruction, and tcm diagnosis: heumatism (superintends and directs sky kidney deficiency, damp and hot resistance network). It does not feel any better still in multiple hospitals treatment, comes in gradually to aggravate.30g is wrapped using medicinal powder 1 every time, baths, 1 times a day, uses 20 Ailing substantially reduced after it, after 60 days, slight illness is completely eliminated, after being discontinued three slightly repeatedly;It is further continued for medication 30 days, stops Medicine;It is discontinued after January without recurrence, recovery from illness.
Compared with prior art, the present invention obtains the Fructus Liquidambaris berry extract of breaking-wall cell using soybean dietary fiber technology Or pericarpium zanthoxyli berry extract, active constituent recovery rate is high, and low temperature extracts active constituent and is not destroyed, and half bionical liquid is extracted to raw material It carries out enzymatic hydrolysis and obtains low molecule active constituent, the effect of dipping is more preferable;Prior to liquid medicine fumigating when use, bathing can enhance immediately Curative effect;
The present invention is suitble to head seen in affection of exogenous wind-cold, the aching and tired pain of body and arthritis, wound or apoplexy sequelae to see there is flesh Meat, joint pain, numbness, weighs the even illnesss such as joint stuffiness at muscles and bones, have expelling wind and clearing away cold promoting blood circulation, dredges and is removed obstruction in channels to relieve pain Effect, effect is good, at low cost, has broad application prospects.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian, which is characterized in that be prepared by the raw material of following parts by weight: Chinese mugwort 1-5 parts of leaf, 0.5-2 parts of lopseed, 0.5-2 parts of lycopodium calvatum, cortex cinnamomi branch 1-3 parts, 1-3 parts of perilla leaf, Fructus Liquidambaris berry extract 1-3 Part, 1-3 parts of pericarpium zanthoxyli berry extract, 1-3 parts of Rhizoma Chuanxiong root.
2. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 1, which is characterized in that by following parts by weight Raw material be prepared: 2.5 parts of folium artemisiae argyi, 1 part of lopseed, 1 part of lycopodium calvatum, cortex cinnamomi branch 1.5 parts, 1.5 parts of perilla leaf, Fructus Liquidambaris fruit 1.5 parts of extract, 1.5 parts of pericarpium zanthoxyli berry extract, 1.5 parts of Rhizoma Chuanxiong root.
3. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 1 or claim 2, which is characterized in that the road road Logical berry extract or pericarpium zanthoxyli berry extract are prepared by following methods: by raw material drying, being ground into little particle, used alcohol solution dipping Ultramicro crushing treatment afterwards, low temperature drying obtain Ultramicro-powder;Semi-bionic extraction method liquid is added into Ultramicro-powder, after 37 DEG C of extraction 1-2h, Enzyme deactivation is cooled to room temperature, and supernatant is collected by centrifugation, and is depressurized low-temperature evaporation, is obtained Fructus Liquidambaris berry extract or pericarpium zanthoxyli berry extract.
4. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 3, which is characterized in that the ethanol solution For the ethanol solution of 75wt%, the soaking time is 2-5h.
5. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 3, which is characterized in that the ultramicro grinding Power be 3000W-4000W, drying temperature be 40 DEG C.
6. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 3, which is characterized in that described half bionical mentions Liquid is taken to be composed of by weight following raw material: 1 part of 15wt% hydrochloric acid, 20 parts of pepsin, 5 parts of ethyl alcohol, 200 parts of water.
7. a kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 3, which is characterized in that the enzyme deactivation condition For 105 DEG C of enzyme deactivation 10min.
8. a kind of preparation side of the dipping preparation of the dispelling wind and eliminating dampness warming and activating meridian as described in any one of claim 1-7 claim Method, which comprises the following steps:
S1. by folium artemisiae argyi, lopseed, lycopodium calvatum, cortex cinnamomi branch, perilla leaf and Rhizoma Chuanxiong root weigh in proportion, wherein rattan, leaf class medium-height grass Medicine, decontamination are cleaned and are drained, and dissection storage, spare respectively;By tubers Chinese herbal medicine, decontamination is cleaned and is drained, is sliced respectively Storage, it is spare;
S2. all medicinal materials got ready are dried into 3-5h for the first time, then is placed in dryer and is dehydrated, drying built-in temperature control Be 100 DEG C -110 DEG C, dehydration to water content is 20%-25%, is taken out, and second dries 2-3h, put back to again in dryer into The dehydration of row dry steam, drying built-in temperature control is 95 DEG C -105 DEG C, and dehydration to water content is 8%-12%;It is placed in dry ring Border storage is spare;
S3. it takes each prescription drug to be uniformly mixed respectively in parts by weight, is placed in Chinese medicine pulper and is blended, blend gained medicine Object crosses 20-60 mesh, is loaded on medicine bag, and medicine bag is put into microwave 2-3min in micro-wave oven, taking-up is placed in dry environment cooling, adds Enter Fructus Liquidambaris berry extract and pericarpium zanthoxyli berry extract, interior packet, the inner packing medicine bag material is gauze or fiber cloth, is refilled in outer It is sealed in packaging to get bath powder.
9. a kind of preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 8, which is characterized in that institute The intensity of illumination for stating sunning for the first time is 60000-80000Lux, and the intensity of illumination of second of sunning is 70000- 90000Lux。
10. a kind of preparation method of the dipping preparation of dispelling wind and eliminating dampness warming and activating meridian according to claim 8, which is characterized in that The microwave power is 1200-1500W.
CN201910905071.9A 2019-09-24 2019-09-24 A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian Pending CN110433218A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910905071.9A CN110433218A (en) 2019-09-24 2019-09-24 A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910905071.9A CN110433218A (en) 2019-09-24 2019-09-24 A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian

Publications (1)

Publication Number Publication Date
CN110433218A true CN110433218A (en) 2019-11-12

Family

ID=68440591

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910905071.9A Pending CN110433218A (en) 2019-09-24 2019-09-24 A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian

Country Status (1)

Country Link
CN (1) CN110433218A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112755101A (en) * 2021-03-18 2021-05-07 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) Traditional Chinese medicine composition for treating knee osteoarthritis and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173338A (en) * 1996-08-12 1998-02-18 王守东 External application powder for removing numbness
CN1742705A (en) * 2005-09-17 2006-03-08 张志祥 Bacteriostatic soaking-bath lotion and preparing technology
CN102716261A (en) * 2012-07-02 2012-10-10 裴保法 Wind-damp expelling traditional Chinese medicine powder
CN104587442A (en) * 2015-02-12 2015-05-06 上海市闸北区中医医院 Foot bath traditional Chinese medicine composition for treating wind-cold-dampness arthralgia and application of foot bath traditional Chinese medicine composition
CN109331167A (en) * 2018-12-25 2019-02-15 陕西华克生物医药有限公司 A kind of attached lavipeditum powder of ginger and preparation method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173338A (en) * 1996-08-12 1998-02-18 王守东 External application powder for removing numbness
CN1742705A (en) * 2005-09-17 2006-03-08 张志祥 Bacteriostatic soaking-bath lotion and preparing technology
CN102716261A (en) * 2012-07-02 2012-10-10 裴保法 Wind-damp expelling traditional Chinese medicine powder
CN104587442A (en) * 2015-02-12 2015-05-06 上海市闸北区中医医院 Foot bath traditional Chinese medicine composition for treating wind-cold-dampness arthralgia and application of foot bath traditional Chinese medicine composition
CN109331167A (en) * 2018-12-25 2019-02-15 陕西华克生物医药有限公司 A kind of attached lavipeditum powder of ginger and preparation method

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
中国食品工业协会营养指导工作委员会: "《公共营养师培训教材》", 31 January 2009 *
吴芸芸: "推荐足浴保健方 ", 《开心老年》 *
朴香兰: "《民族药物提取分离新技术》", 31 October 2011 *
艾裕生物科技: "全身无力?中药泡澡包帮你揪出根源!", 《全身无力?中药泡澡包帮你揪出根源! *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112755101A (en) * 2021-03-18 2021-05-07 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) Traditional Chinese medicine composition for treating knee osteoarthritis and application thereof
CN112755101B (en) * 2021-03-18 2021-11-02 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) Traditional Chinese medicine composition for treating knee osteoarthritis and application thereof

Similar Documents

Publication Publication Date Title
CN102091203B (en) External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof
CN102091258B (en) Chinese medicinal composition for dispelling scars and preparation method thereof
CN104208580B (en) It is a kind of to treat Chinese medicine composition for the treatment of rheumatic ostealgia and preparation method thereof
CN104367911B (en) Treat Chinese medicine composition of rheumatism and rheumatoid arthritis and preparation method thereof
CN107596312A (en) A kind of Chinese medicine pedicure bag with auxiliary treatment effect and preparation method thereof
CN102319380B (en) Method for preparing Chinese medicinal lotion for treating foot pressure sore
CN110433218A (en) A kind of dipping preparation of dispelling wind and eliminating dampness warming and activating meridian
CN104383384A (en) Traditional Chinese medicine washing liquid for treating tinea of feet and hands
CN105494780A (en) Chinese hawthorn leaf health-care tea capable of protecting liver and lowering lipid and preparation method thereof
CN106138436A (en) A kind of Chinese medicine treating prolapse of lumbar intervertebral disc and hyperosteogeny and preparation method thereof
CN106581241A (en) Burn and scald treating traditional Chinese medicine composition
CN105663370A (en) Externally-used medicine for treating verruca plantaris
CN102078491B (en) Fumigating and washing medicine decoction for eliminating blood stasis and activating blood circulation and use method thereof
CN105250685A (en) Traditional Chinese medicine composition for treating burns and preparation method of traditional Chinese medicine composition
CN104906517B (en) It is a kind of treat because of hypertension caused by hemiplegia drug
CN109329487A (en) A kind of health tea and preparation method thereof to clear liver and improve vision
CN108543049A (en) Muscle tea and preparation method thereof is stretched in a kind of clearing and activating the channels and collaterals
CN106963685A (en) Plant Eradicates spot beautifying liquids
CN102784355A (en) First-aid drug and its preparation method
CN107375851A (en) For treating the medicine of scleroderma circumscriptum
CN102920910B (en) Traditional Chinese medicine for treating chronic pancreatitis
CN107661391A (en) Treat Yao nationality medicine external preparation of the proliferation of mammary gland and preparation method thereof
CN106924673A (en) A kind of Chinese medicine composition for treating osteoproliferation and its medicament preparation method
CN102205075B (en) Preparation method and application of external application ointment composition for treating mastopathy
CN101357153B (en) No-scar medicine for treating burn and scald and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20191112

RJ01 Rejection of invention patent application after publication