CN110432264A - A kind of medicament-carrying nano-microsphere, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof - Google Patents
A kind of medicament-carrying nano-microsphere, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof Download PDFInfo
- Publication number
- CN110432264A CN110432264A CN201910726959.6A CN201910726959A CN110432264A CN 110432264 A CN110432264 A CN 110432264A CN 201910726959 A CN201910726959 A CN 201910726959A CN 110432264 A CN110432264 A CN 110432264A
- Authority
- CN
- China
- Prior art keywords
- medicament
- microsphere
- carrying nano
- slow releasing
- neck ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000045947 parasite Species 0.000 title claims abstract description 31
- 239000004005 microsphere Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims description 15
- 239000003814 drug Substances 0.000 claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 13
- 239000013335 mesoporous material Substances 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 229920000642 polymer Polymers 0.000 claims abstract description 7
- 238000012545 processing Methods 0.000 claims abstract description 6
- 238000000465 moulding Methods 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 12
- 229910021641 deionized water Inorganic materials 0.000 claims description 12
- 239000002131 composite material Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 238000005453 pelletization Methods 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 9
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 229920002635 polyurethane Polymers 0.000 claims description 7
- 239000004814 polyurethane Substances 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 238000001354 calcination Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000003607 modifier Substances 0.000 claims description 6
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 6
- 229920001610 polycaprolactone Polymers 0.000 claims description 6
- 239000004632 polycaprolactone Substances 0.000 claims description 6
- 239000000899 Gutta-Percha Substances 0.000 claims description 5
- 240000000342 Palaquium gutta Species 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 229920000588 gutta-percha Polymers 0.000 claims description 5
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical group [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 4
- GPCVJWKRADKZBO-UHFFFAOYSA-N S.N.C1(=CC=CC=C1)C Chemical compound S.N.C1(=CC=CC=C1)C GPCVJWKRADKZBO-UHFFFAOYSA-N 0.000 claims description 4
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 4
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- -1 polyethylene Polymers 0.000 claims description 4
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical class [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 239000003093 cationic surfactant Substances 0.000 claims description 2
- 239000007822 coupling agent Substances 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229920002101 Chitin Polymers 0.000 claims 1
- PNKUSGQVOMIXLU-UHFFFAOYSA-N Formamidine Chemical compound NC=N PNKUSGQVOMIXLU-UHFFFAOYSA-N 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229940031098 ethanolamine Drugs 0.000 claims 1
- 239000003630 growth substance Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 239000002949 juvenile hormone Substances 0.000 claims 1
- 229930014550 juvenile hormone Natural products 0.000 claims 1
- 150000003633 juvenile hormone derivatives Chemical class 0.000 claims 1
- 230000002045 lasting effect Effects 0.000 claims 1
- 238000010907 mechanical stirring Methods 0.000 claims 1
- XYFMGGWVGACNEC-UHFFFAOYSA-N n-carbamoyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C(=O)N)C(=O)C1=CC=CC=C1 XYFMGGWVGACNEC-UHFFFAOYSA-N 0.000 claims 1
- 150000008048 phenylpyrazoles Chemical class 0.000 claims 1
- 239000002728 pyrethroid Substances 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000000507 anthelmentic effect Effects 0.000 abstract description 7
- 230000036541 health Effects 0.000 abstract description 7
- 238000003756 stirring Methods 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 5
- 230000004048 modification Effects 0.000 abstract description 4
- 238000012986 modification Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 208000030852 Parasitic disease Diseases 0.000 abstract description 2
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 238000011068 loading method Methods 0.000 abstract description 2
- 239000011148 porous material Substances 0.000 abstract description 2
- 206010048282 zoonosis Diseases 0.000 abstract 1
- 244000000013 helminth Species 0.000 description 12
- 108010034145 Helminth Proteins Proteins 0.000 description 9
- 238000005119 centrifugation Methods 0.000 description 7
- 210000003608 fece Anatomy 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 238000000967 suction filtration Methods 0.000 description 6
- 241000790917 Dioxys <bee> Species 0.000 description 4
- 229910003978 SiClx Inorganic materials 0.000 description 4
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- 229960000935 dehydrated alcohol Drugs 0.000 description 4
- 238000003760 magnetic stirring Methods 0.000 description 4
- 239000002077 nanosphere Substances 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 229910000077 silane Inorganic materials 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 239000005906 Imidacloprid Substances 0.000 description 3
- 241000002163 Mesapamea fractilinea Species 0.000 description 3
- YXWCBRDRVXHABN-JCMHNJIXSA-N [cyano-(4-fluoro-3-phenoxyphenyl)methyl] 3-[(z)-2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropane-1-carboxylate Chemical compound C=1C=C(F)C(OC=2C=CC=CC=2)=CC=1C(C#N)OC(=O)C1C(C)(C)C1\C=C(/Cl)C1=CC=C(Cl)C=C1 YXWCBRDRVXHABN-JCMHNJIXSA-N 0.000 description 3
- 229940056881 imidacloprid Drugs 0.000 description 3
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 241000244203 Caenorhabditis elegans Species 0.000 description 2
- 229960002587 amitraz Drugs 0.000 description 2
- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000008451 emotion Effects 0.000 description 2
- 244000079386 endoparasite Species 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000077 insect repellent Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241001465677 Ancylostomatoidea Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000242722 Cestoda Species 0.000 description 1
- 239000005893 Diflubenzuron Substances 0.000 description 1
- 239000005899 Fipronil Substances 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000790252 Otodectes cynotis Species 0.000 description 1
- 241000509427 Sarcoptes scabiei Species 0.000 description 1
- 241001074085 Scophthalmus aquosus Species 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 241000254223 Syntexis Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 description 1
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 description 1
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 description 1
- 229940019503 diflubenzuron Drugs 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 229940013764 fipronil Drugs 0.000 description 1
- RYLHNOVXKPXDIP-UHFFFAOYSA-N flufenoxuron Chemical compound C=1C=C(NC(=O)NC(=O)C=2C(=CC=CC=2F)F)C(F)=CC=1OC1=CC=C(C(F)(F)F)C=C1Cl RYLHNOVXKPXDIP-UHFFFAOYSA-N 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229950003442 methoprene Drugs 0.000 description 1
- 229930002897 methoprene Natural products 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
- 229960000490 permethrin Drugs 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K27/00—Leads or collars, e.g. for dogs
- A01K27/007—Leads or collars, e.g. for dogs with insecticide-dispensing means
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of medicament-carrying nano-microspheres, functional modification is carried out to template object using modified additive, prepare the mesoporous material that there is uniform pore size and stablize release drug, since surface modification can be with template object surface generating unit point chemical reaction, pass through the method for dissolve-repreparation, using the means vacuumized by drug loading to mesoporous road, mesoporous material-medicament-carrying nano-microsphere of carrying medicament is made.Reselection has the high molecular polymer of good biocompatibility, preferable mechanical performance, carries out blending and stirring, molding, slow releasing pharmaceutical expelling parasite Pet neck ring with program and medicament-carrying nano-microsphere according to a certain ratio.Slow releasing pharmaceutical expelling parasite Pet neck ring of the invention has good mechanical property, excellent anthelminthic effect and preferable biocompatibility, and production and processing convenience is easy the features such as preparing；It can be widely applied in pet field, especially pet health management domain, the accuracy for curing parasitic disease can be improved, provide new approach to reduce zoonosis.
Description
Technical field
The invention belongs to pet health medicine and high molecular material New Processing field, and in particular to a kind of load medicine is received
Meter Wei Qiu, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof.
Background technique
As pet more and more enters the family of people, they have played the value of itself well, or accompany
With owner, or it is to aid in owner, almost every kind of pet can meet the needs of owner is in terms of certain.In the process accompanied mutually
In, owner is higher and higher for the attention degree of pet, more and more emotions is generated, or even as a member of family, in this feelings
Under condition, a kind of emotion that concern pet health becomes pet owner is entrusted to the care of, and also becomes the normality in pet life.
Pet is influenced by factors such as rearing conditions, raising habits, can generate some helminths in vivo.Such as to pet
Dog dog eats raw meat, pet likes brill thick grass etc. all can generate the chance of helminth to its inside and outside.Pet helminth is divided into external
Helminth and endoparasite, vermin mainly have: flea, louse, itch mite, ear mite, tick worm etc., infect vermin
Pet usually can be with pruitus, redness, pain etc., such as flea, skin will appear redness after pet infection flea,
Also it can lose hair or feathers and suppurate when serious；Endoparasite is mainly roundworm, tapeworm, hookworm, heartworm, infects these helminths, dotes on
Object can generate loss of appetite, syntexis, listless etc., wherein infection heartworm is likely to cause pet sudden death.And owner be with
The people that pet is in the most contact, some pet owners, which are also eaten together with pet, sleeps together, the parasitic infection being easiest to by pet, as
The helminths such as flea, roundworm, heartworm are all that people dotes on total trouble, they can not only endanger the health of pet, while can also endanger and dote on
The health of owner people.For family health, especially child and old man, while ensuring the health of pet, love is doted on and is timed
Expelling parasite is very important.
Summary of the invention
In view of the active love of pet is dynamic and the complexity of feeding environment, the present invention researches and develops a kind of medicament-carrying nano-microsphere, and with
Medicament-carrying nano-microsphere and high molecular polymer are raw material, are prepared into a kind of slow releasing pharmaceutical expelling parasite Pet neck ring, have good life
Object compatibility, suitable mechanical property and good anthelminthic effect.
To solve the above problems, the invention is realized by the following technical scheme:
Slow releasing pharmaceutical expelling parasite Pet neck ring of the present invention, which is characterized in that the raw material including following parts by weight: high molecular polymer
60-99 parts and medicament-carrying nano-microsphere 1-40 parts.
The high molecular polymer is one of polyurethane, gutta-percha, polyethylene, silicon rubber and polycaprolactone or one
Kind or more.The polyurethane molecular amount is not less than 80,000, and gutta-percha molecular weight is not less than 80,000, and Molecular Weight of Silicone Rubber is not less than 10
Ten thousand, polycaprolactone molecular weight is not less than 40,000.
The medicament-carrying nano-microsphere is made of following steps:
(1) surfactant is soluble in water, under the conditions of 60-85 DEG C persistently stir (revolving speed 1000-2000rpm), successively plus
Enter triethanolamine and ethyl orthosilicate, be centrifuged suction filtration after being stirred to react 1-5h, gained filter residue is dried into (40-80 DEG C), (is placed in horse
Not in furnace) calcining (300-700 DEG C of calcining 2-6h), obtain powder mesoporous particles；
(2) by gained powder mesoporous particles and dimethylbenzene, surface modifier under nitrogen atmosphere protection, in 80-96 DEG C of water-bath
24-48h is reacted, is then centrifuged, filtered, gained filter residue is dried into (50-85 DEG C), obtains modified mesoporous material；
(3) gained modified mesoporous material and a certain amount of drug are placed in ethyl alcohol, (ultrasound) disperses 0.5-5h, then (is with revolving speed
1200-3000rpm stirring) vacuum decentralized processing 5-60min, while deionized water is added dropwise, continue to disperse 20-48h, then carry out
Centrifugation filters, drying (55-80 DEG C), obtains medicament-carrying nano-microsphere.
Surfactant as described in step (1) is cationic surfactant or anionic surfactant, middle-jiao yang, function of the spleen and stomach
Ionic surface active agent be cetyl trimethylammonium bromide, cetyl trimethyl to one of toluene sulphur ammonium or it is a kind of with
On；Anionic surfactant be one of anionic polyacrylamide, neopelex or more than one.
Surface modifier described in step (2) is silane coupling agent, stearic acid, oleic acid, one in titanate coupling agent
Kind or more than one.
Drug described in step (3) is Amitraz, imidacloprid, Nylar, Fipronil, basudin, decis, kills
Worm fear, methoprene, Permethrin and Flumethrin, diflubenzuron, d ichlorbenzuron, flufenoxuron, rice are one of full etc. or a kind of
More than.
Surfactant used in step (1): triethanolamine: ethyl orthosilicate: the ratio between water is (0.1-2g):
(0.1-1g): (5-10mL): (40-100mL).
Powder mesoporous particles used in step (2): dimethylbenzene: the ratio between surface modifier is (0.1-2g):
(50-100mL): (1-10mL).
Modified mesoporous material used in step (3): drug: ethyl alcohol: the ratio between deionized water is (0.1-1g):
(0.1-5g): (20-50mL): (20-50mL).
The preparation method of above-mentioned slow releasing pharmaceutical expelling parasite Pet neck ring, comprising the following steps:
The raw material (10-60min at high-speed mixer revolving speed 3000-5000rpm) is blended uniformly the first step, then will
Mixture adds twin-screw extrude melting mixing extrusion, then carries out cooling, pelletizing, obtains slow releasing pharmaceutical composite material granular
Material；
Each parameter setting of double screw extruder are as follows:
Second step prepares slow releasing pharmaceutical expelling parasite Pet neck ring by molding equipment (hot press, press machine or melting pelleter).
The present invention has following positive beneficial effect:
(1) expelling parasite Pet neck ring of the present invention has good mechanical property, excellent anthelminthic effect and preferable biocompatibility；
In addition, the expelling parasite Pet neck ring obtained has drug slow release function, stable anthelmintic action can be reached with sustained release drugs, is improved
The purpose of the effective expelling parasite of pet；
(2) present invention carries out functional modification to template object using modified additive, and preparation has uniform pore size and stablizes release
The mesoporous material of drug.Since surface modification can pass through the side of dissolve-repreparation with template object surface generating unit point chemical reaction
The mesoporous material that carrying medicament in drug loading to mesoporous road, is made is had acid response release using the means vacuumized by method
The function of drug, and there is excellent biocompatibility.
(3) present invention uses medical grade polycaprolactone for high molecular polymer, and backbone provides excellent soft bullet
Property, draftability and suitable viscosity, may not need binder, and then improve the accuracy of production and processing, using comfortable etc..
Detailed description of the invention
For the technical solution that the present invention is furture elucidated, institute in embodiment or description of the prior art will be simply introduced below
Attached drawing to be used is needed, drawings in the following description are only some embodiments of the invention, for ordinary skill people
For member, without creative efforts, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is the process flow chart of the embodiment of the present invention 1；
Fig. 2 is the external elution profiles of 1-4 of the embodiment of the present invention.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples, but embodiments of the present invention are not limited thereto.
Embodiment 1
A kind of slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by the component of polyurethane and medicament-carrying nano-microsphere based on following parts by weight
It forms:
Polyurethane: 78 parts,
Medicament-carrying nano-microsphere: 22 parts.
The preparation method of medicament-carrying nano-microsphere uses following steps:
(1) 1.25g cetyl trimethyl is dissolved in 50mL deionized water toluene sulphur ammonium, magnetic agitation at 80 DEG C, successively
0.15g triethanolamine and 8.0mL ethyl orthosilicate is added, is centrifuged suction filtration after stirring 2h, 60 DEG C of drying are placed in 600 DEG C of Muffle furnaces
Middle calcining 4h obtains powder LMSN mesoporous particles；
(2) powder LMSN mesoporous particles and 100mL dimethylbenzene, the 1.85mL for weighing 1.25g above-mentioned steps (1) acquisition are silane coupled
Agent is reacted for 24 hours under nitrogen atmosphere protection in 95 DEG C of water-baths, and centrifugation filters, and drying is obtained with amino modified mesoporous dioxy
SiClx NH2-LMSN；
(3) the 0.10g NH for preparing above-mentioned steps (2)2- LMSN and 0.5g Amitraz are placed in 20mL dehydrated alcohol, ultrasound
0.5h is vacuum-treated 10min under magnetic stirring, and 20mL deionized water is added dropwise, and vibrates in shaking table for 24 hours, centrifugation, suction filtration, 60
DEG C drying, obtain the nanosphere of carrying medicament.
The preparation method of the present embodiment slow releasing pharmaceutical expelling parasite Pet neck ring, comprising the following steps:
(1) 10min is blended at high-speed mixer 3000rpm in above-mentioned raw materials, obtains uniform mixture；It then, will be uniform
Mixture be added in double screw extruder that melting mixing squeezes out, water is cooling and pelletizing, twin-screw temperature setting an are as follows: area 160
DEG C, 165 DEG C of 2nd area, 170 DEG C of 3rd area, 175 DEG C of 4th area, 180 DEG C of 5th area, 170 DEG C of head area, 155 DEG C of melt temperature, twin-screw turn
Speed is 18.5r/min, and pelletizing speed is 11.3r/min, finally obtains uniformly mixed composite material granular material；
(2) slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by hot press, sees Fig. 2.
Embodiment 2
A kind of slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by the component of polyurethane and medicament-carrying nano-microsphere based on following parts by weight
It forms:
Polyurethane: 85 parts,
Medicament-carrying nano-microsphere: 15 parts.
The preparation method of medicament-carrying nano-microsphere, using following steps:
(1) 0.96g cetyl trimethylammonium bromide is dissolved in 50mL deionized water, magnetic agitation at 85 DEG C sequentially adds
0.2g triethanolamine and 8.0mL ethyl orthosilicate are centrifuged suction filtration after stirring 1h, and 70 DEG C of drying are placed in 700 DEG C of Muffle furnaces and calcine
3h obtains powder SMSN mesoporous particles；
(2) powder SMSN mesoporous particles and 100mL dimethylbenzene, the 1.5mL for weighing 0.96g above-mentioned steps (1) acquisition are silane coupled
Agent reacts 20h under nitrogen atmosphere protection in 90 DEG C of water-baths, and centrifugation filters, and drying is obtained with amino modified mesoporous dioxy
SiClx NH2-SMSN；
(3) the 0.10g NH for preparing above-mentioned steps (2)2- SMSN and 0.4g imidacloprid are placed in 20mL dehydrated alcohol, ultrasound
1h is vacuum-treated 20min under magnetic stirring, and 20mL deionized water is added dropwise, and vibrates in shaking table for 24 hours, and centrifugation filters, 80 DEG C
Drying, obtains the nanosphere of carrying medicament.
The preparation method of the present embodiment slow releasing pharmaceutical expelling parasite Pet neck ring, comprising the following steps:
(1) 20min is blended at high-speed mixer 1500rpm in above-mentioned raw materials, obtains uniform mixture；It then, will be uniform
Mixture be added in double screw extruder melting mixing squeeze out, air cooling and pelletizing, twin-screw temperature setting an are as follows: area 170
DEG C, 175 DEG C of 2nd area, 176 DEG C of 3rd area, 178 DEG C of 4th area, 180 DEG C of 5th area, 175 DEG C of head area, 167 DEG C of melt temperature, twin-screw turn
Speed is 20r/min, and pelletizing speed is 15r/min, finally obtains uniformly mixed composite material granular material；
(2) slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by hot press.
Embodiment 3
A kind of slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by the component of gutta-percha and medicament-carrying nano-microsphere based on following parts by weight
It forms:
Gutta-percha: 65 parts,
Medicament-carrying nano-microsphere: 35 parts.
The preparation method of medicament-carrying nano-microsphere, using following steps:
(1) 0.96g cetyl trimethylammonium bromide is dissolved in 50mL deionized water, magnetic agitation at 90 DEG C sequentially adds
0.15g triethanolamine and 8.0mL ethyl orthosilicate are centrifuged suction filtration after stirring 2h, and 80 DEG C of drying are placed in 600 DEG C of Muffle furnaces and forge
5h is burnt, powder SMSN mesoporous particles are obtained；
(2) powder SMSN mesoporous particles and 100mL dimethylbenzene, the 1.85mL for weighing 0.96g above-mentioned steps (1) acquisition are silane coupled
Agent reacts 20h under nitrogen atmosphere protection in 90 DEG C of water-baths, and centrifugation filters, and drying is obtained with amino modified mesoporous dioxy
SiClx NH2-SMSN；
(3) the 0.10g NH for preparing above-mentioned steps (2)2- SMSN and 0.6g imidacloprid and 0.2g Flumethrin are placed in
In 20mL dehydrated alcohol, ultrasonic 1h is vacuum-treated 20min under magnetic stirring, and 20mL deionized water is added dropwise, vibrates in shaking table
For 24 hours, it is centrifuged, filters, 60 DEG C of drying, obtaining the nanosphere of carrying medicament.
The preparation method of the present embodiment slow releasing pharmaceutical expelling parasite Pet neck ring, comprising the following steps:
(1) 15min is blended at high-speed mixer 4000rpm in above-mentioned raw materials, obtains uniform mixture；It then, will be uniform
Mixture be added in double screw extruder that melting mixing squeezes out, water is cooling and pelletizing, twin-screw temperature setting an are as follows: area 172
DEG C, 175 DEG C of 2nd area, 178 DEG C of 3rd area, 182 DEG C of 4th area, 185 DEG C of 5th area, 180 DEG C of head area, 169 DEG C of melt temperature, twin-screw turn
Speed is 16r/min, and pelletizing speed is 10r/min, finally obtains uniformly mixed composite material granular material；
(2) slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by melt extruder.
Embodiment 4
A kind of component system of slow releasing pharmaceutical expelling parasite Pet neck ring by polycaprolactone and medicament-carrying nano-microsphere based on following parts by weight
It is standby to form:
Polycaprolactone: 90 parts,
Medicament-carrying nano-microsphere: 10 parts.
The preparation method of medicament-carrying nano-microsphere, using following steps:
(1) 1.25g cetyl trimethyl is dissolved in 60mL deionized water toluene sulphur ammonium, magnetic agitation at 75 DEG C, successively
0.15g triethanolamine and 8.0mL ethyl orthosilicate is added, is centrifuged suction filtration after stirring 3h, 80 DEG C of drying are placed in 650 DEG C of Muffle furnaces
Middle calcining 4.5h obtains powder LMSN mesoporous particles；
(2) powder LMSN mesoporous particles and 100mL dimethylbenzene, the 1.85mL for weighing 1.25g above-mentioned steps (1) acquisition are silane coupled
Agent is reacted for 24 hours under nitrogen atmosphere protection in 85 DEG C of water-baths, and centrifugation filters, and drying is obtained with amino modified mesoporous dioxy
SiClx NH2-LMSN；
(3) the 0.10g NH for preparing above-mentioned steps (2)2- LMSN and 0.5g Flumethrin are placed in 20mL dehydrated alcohol,
Ultrasonic 2h is vacuum-treated 10min under magnetic stirring, and 20mL deionized water is added dropwise, and 30h is vibrated in shaking table, be centrifuged, filter,
80 DEG C of drying, obtain the nanosphere of carrying medicament.
The preparation method of the present embodiment slow releasing pharmaceutical expelling parasite Pet neck ring, comprising the following steps:
(1) 10min is blended at high-speed mixer 4500rpm in above-mentioned raw materials, obtains uniform mixture；It then, will be uniform
Mixture be added in double screw extruder that melting mixing squeezes out, water is cooling and pelletizing, twin-screw temperature setting an are as follows: area 178
DEG C, 180 DEG C of 2nd area, 183 DEG C of 3rd area, 185 DEG C of 4th area, 190 DEG C of 5th area, 184 DEG C of head area, 170 DEG C of melt temperature, twin-screw turn
Speed is 24r/min, and pelletizing speed is 16r/min, finally obtains uniformly mixed composite material granular material；
(2) slow releasing pharmaceutical expelling parasite Pet neck ring is prepared by sheet-punching machine.
Performance test:
Composite material prepared in embodiment 1-4 step is printed as standard batten using injection molding machine, to batten obtained into
Row Mechanics Performance Testing refers to GB 1040-2006, GB 9341-2008 and GB 1043-2008 respectively；Biocompatibility reference
MTT test is tested in YY/T 0993-2015, and the anthelminthic effect of composite material is tested with reference to following scheme, above-mentioned reality
The performance for applying sample obtained by example is more as shown in table 1.
1 slow releasing pharmaceutical composite property testing result of table
Anthelminthic effect testing scheme: from July, 2018 to during in October, 2018, in Guangdong Quan Zhi farm, implemented
The performance measurement test of example, is tested duration 2 months.Choose 5 independent doghouses, each each 10 small-sized Poodles of doghouse, male and female
Fifty-fifty, monthly age and weight are suitable, only cage raising.Doghouse 1-4 carries the necklace of above-described embodiment 1-4 respectively, and the 5th doghouse is sky
White control group, does not make specially treated.To judge the other safety of each group and insect-repellent, the 2nd day after wearing necklace, the 10th
It, the 30th day and the 60th day, whether the body surface for detecting experimental animal there are the allergic phenomenas such as redness, hair loss, if there is obvious skin
Skin is damaged, remembers 0 point；There is fash, remembers 1 point；Only there is red and swollen, 2 points of note；There is hair missing, remember 3 points, without significant abnormal, note
5 points.Go through experimental animal simultaneously, be confirmed whether to occur the adults of common vermin such as flea, louse or tick worm or
Excreta, if discovery remembers 0 point more than 5 or more adults and discovery helminth excreta；It was found that 2 or more 5 or less adults,
Regardless of whether there is helminth excreta, 1 point is remembered；It was found that 1 to 2 adult and helminth excreta, or without discovery adult but post
Infested excreta remembers 2 points；It was found that 2 or less adults, but without discovery helminth excreta, remember 3 points；Without discovery adult and helminth
Excreta remembers 5 points.Each group average record is as follows:
2 clinical test results of table
Conclusion: the safety of embodiment 3 and disinsectization performance are the most outstanding, and embodiment 1,2 and 4 is slightly taken second place, but aobvious in general
It writes better than the blank test group 5 without using embodiment, it was demonstrated that invention described in this patent can effectively prevent the epizoonosis of dog.
As shown in Table 1, a kind of above-mentioned slow releasing pharmaceutical expelling parasite Pet neck ring composite material have good mechanical property and compared with
The features such as good biocompatibility, production and processing is simple, is easy preparation.By the safety and insect-repellent in table 2 it is found that above-mentioned system
Standby Pet neck ring has excellent anthelmintic action and biocompatibility, can effectively inhibit the growth of helminth, it is ensured that pet
It grows up healthy and sound.
Above-mentioned case study on implementation only describes several specific embodiments of the invention, rather than to the invention patent model
The limitation enclosed, it may be that, it for those of ordinary skill in the art, without creative efforts, can be with
Different improvement is made according to these attached drawings and obtains other attached drawings, and these are all within the scope of protection of the present invention.Therefore, this hair
The scope of protection shall be subject to the appended claims for bright patent.
Claims (10)
1. a kind of medicament-carrying nano-microsphere, which is characterized in that be prepared from the following steps:
(1) surfactant is soluble in water, it is persistently stirred under the conditions of 60-85 DEG C, sequentially adds triethanolamine and positive silicic acid second
Ester is centrifuged after being stirred to react and filters, gained filter residue is dried, and calcines, obtains powder mesoporous particles；
(2) by gained powder mesoporous particles and dimethylbenzene, surface modifier under nitrogen atmosphere protection, in 80-96 DEG C of water-bath
24-48h is reacted, is then centrifuged, filtered, gained filter residue is dried, modified mesoporous material is obtained；
(3) gained modified mesoporous material and a certain amount of drug are placed in ethyl alcohol, disperse, then vacuum decentralized processing, is added dropwise simultaneously
Deionized water continues to disperse 20-48h, is then centrifuged, filtered, dried, obtains medicament-carrying nano-microsphere.
2. medicament-carrying nano-microsphere according to claim 1, it is characterised in that: the surfactant is cationic surface
Activating agent or anionic surfactant, wherein cationic surfactant is cetyl trimethylammonium bromide, cetyl
Trimethyl to one of toluene sulphur ammonium or more than one；Anionic surfactant is anionic polyacrylamide, dodecane
One of base benzene sulfonic acid sodium salt or more than one；The surface modifier is silane coupling agent, stearic acid, oleic acid, titanate esters
One of coupling agent or more than one.
3. medicament-carrying nano-microsphere according to claim 1, it is characterised in that: surfactant used in step (1): three
Ethanol amine: ethyl orthosilicate: the ratio between water is (0.1-2) g:(0.1-1) g:(5-10) mL:(40-100) mL.
4. medicament-carrying nano-microsphere according to claim 1, it is characterised in that: powder mesoporous particles used in step (2):
Dimethylbenzene: the ratio between surface modifier is (0.1-2) g:(50-100) mL:(1-10) mL.
5. medicament-carrying nano-microsphere according to claim 1, it is characterised in that: modified mesoporous material used in step (3):
Drug: ethyl alcohol: the ratio between deionized water is (0.1-1) g:(0.1-5) g:(20-50) mL:(20-50) mL.
6. medicament-carrying nano-microsphere according to claim 1, it is characterised in that: step (1) is described to be stirred to react lasting 1-5h,
The drying condition is 40-80 DEG C, and the calcining is to be placed in Muffle furnace with 300-700 DEG C of calcining 2-6h；Step (2) described baking
Dry condition is 50-85 DEG C；Step (3) is described to be separated into ultrasonic disperse 0.5-5h, and the vacuum is separated under vacuumized conditions
Mechanical stirring 5-60min, the drying condition are 55-80 DEG C.
7. a kind of slow releasing pharmaceutical expelling parasite Pet neck ring, which is characterized in that the raw material including following parts by weight: high molecular polymer
Described medicament-carrying nano-microsphere 1-40 parts of any one of 60-99 parts and claim 1-7.
8. slow releasing pharmaceutical expelling parasite Pet neck ring according to claim 7, it is characterised in that: the high molecular polymer is
One of polyurethane, gutta-percha, polyethylene, silicon rubber and polycaprolactone or more than one.
9. slow releasing pharmaceutical expelling parasite Pet neck ring according to claim 7, it is characterised in that: the drug is pyrethroid
Esters, phenyl pyrazoles, formamidine, nicotinoids, organophosphorus insecticides and juvenile hormone class, phenylate class, benzoylphenyl urea, anti-guarantor
One of young steroids, moulting hormone class, chitin synthesis inhibitor class insect growth regulator, IGR or more than one.
10. the preparation method of slow releasing pharmaceutical expelling parasite Pet neck ring described in claim 7, which comprises the following steps:
The raw material is blended uniformly the first step, then feeds the mixture into melting mixing in double screw extruder and squeezes out, then into
Row cooling, pelletizing obtain slow releasing pharmaceutical composite material granular material；
Each parameter setting of double screw extruder are as follows:
Second step prepares slow releasing pharmaceutical expelling parasite Pet neck ring by molding equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910726959.6A CN110432264A (en) | 2019-08-07 | 2019-08-07 | A kind of medicament-carrying nano-microsphere, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910726959.6A CN110432264A (en) | 2019-08-07 | 2019-08-07 | A kind of medicament-carrying nano-microsphere, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110432264A true CN110432264A (en) | 2019-11-12 |
Family
ID=68433784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910726959.6A Pending CN110432264A (en) | 2019-08-07 | 2019-08-07 | A kind of medicament-carrying nano-microsphere, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110432264A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111235756A (en) * | 2020-02-15 | 2020-06-05 | 华南农业大学 | Novel dustproof, antibacterial and antiviral nanofiber mask |
| CN111869957A (en) * | 2020-07-13 | 2020-11-03 | 黑龙江东方学院 | Fungi-proofing fog-absorbing mask |
| CN113575575A (en) * | 2021-08-09 | 2021-11-02 | 华南农业大学 | Film-coated drug-loaded microsphere, drug-sustained-release insect-expelling pet collar and preparation method thereof |
| CN115885989A (en) * | 2022-10-20 | 2023-04-04 | 河北农业大学 | Slow-release pyrethroid nanoparticle and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101337072A (en) * | 2008-08-19 | 2009-01-07 | 北京工业大学 | Preparation method of sustained and controlled release medicine material |
| CN101511191A (en) * | 2006-09-11 | 2009-08-19 | 住友化学株式会社 | Method for preparing insect-repellent compound-containing resin pellet |
| CN101921427A (en) * | 2010-08-06 | 2010-12-22 | 奇瑞汽车股份有限公司 | Functional high-polymer decorative composite material and preparation method thereof |
| CN103882543A (en) * | 2014-02-10 | 2014-06-25 | 上海市合成纤维研究所 | Anti-mite antibacterial thermoplastic polymer melt spun fiber and preparation method thereof |
| EP3094666A1 (en) * | 2014-01-14 | 2016-11-23 | Université de Strasbourg | Disintegratable porous organometaloxide material |
-
2019
- 2019-08-07 CN CN201910726959.6A patent/CN110432264A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101511191A (en) * | 2006-09-11 | 2009-08-19 | 住友化学株式会社 | Method for preparing insect-repellent compound-containing resin pellet |
| CN101337072A (en) * | 2008-08-19 | 2009-01-07 | 北京工业大学 | Preparation method of sustained and controlled release medicine material |
| CN101921427A (en) * | 2010-08-06 | 2010-12-22 | 奇瑞汽车股份有限公司 | Functional high-polymer decorative composite material and preparation method thereof |
| EP3094666A1 (en) * | 2014-01-14 | 2016-11-23 | Université de Strasbourg | Disintegratable porous organometaloxide material |
| CN103882543A (en) * | 2014-02-10 | 2014-06-25 | 上海市合成纤维研究所 | Anti-mite antibacterial thermoplastic polymer melt spun fiber and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 吴范宏等: "《应用化学》", 31 August 2016, 上海：华东理工大学出版社 * |
| 杨涛等: "介孔二氧化硅的合成与表征", 《湖南冶金职业技术学院学报》 * |
| 林春梅等: "纳米二氧化硅表面改性及其对阿维菌素吸附和缓释性能", 《生态环境学报》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111235756A (en) * | 2020-02-15 | 2020-06-05 | 华南农业大学 | Novel dustproof, antibacterial and antiviral nanofiber mask |
| CN111235756B (en) * | 2020-02-15 | 2021-06-04 | 华南农业大学 | Novel dustproof, antibacterial and antiviral nanofiber mask |
| CN111869957A (en) * | 2020-07-13 | 2020-11-03 | 黑龙江东方学院 | Fungi-proofing fog-absorbing mask |
| CN113575575A (en) * | 2021-08-09 | 2021-11-02 | 华南农业大学 | Film-coated drug-loaded microsphere, drug-sustained-release insect-expelling pet collar and preparation method thereof |
| CN113575575B (en) * | 2021-08-09 | 2022-01-28 | 华南农业大学 | Film-coated drug-loaded microsphere, drug-sustained-release insect-expelling pet collar and preparation method thereof |
| CN115885989A (en) * | 2022-10-20 | 2023-04-04 | 河北农业大学 | Slow-release pyrethroid nanoparticle and preparation method and application thereof |
| CN115885989B (en) * | 2022-10-20 | 2024-05-03 | 河北农业大学 | Sustained-release pyrethroid nanoparticle and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110432264A (en) | A kind of medicament-carrying nano-microsphere, slow releasing pharmaceutical expelling parasite Pet neck ring and preparation method thereof | |
| DE60319969T2 (en) | TASTEFUL FIXED MEDICINAL PRODUCTS FOR ANIMALS | |
| US9078924B2 (en) | Oral delivery vehicle and material | |
| US11103524B2 (en) | Compositions for oral administration to animals, processes for obtaining the same and the uses thereof | |
| JP2017533959A (en) | Veterinary composition with high palatability and chewability | |
| JPH05500668A (en) | controlled release composition | |
| DE2445971A1 (en) | MEDICINAL INGREDIENTS CARRIERS II | |
| EP0009688B1 (en) | Medical food based on liver powder and process for its preparation | |
| CN101045064A (en) | Gitamycin slow-release micro-ball preparation and its preparing process | |
| CN104958764A (en) | Tilmicosin smell masking preparation and preparing method thereof | |
| CN106666085A (en) | Functional snack for pet dogs and preparation method thereof | |
| CN113171358A (en) | Pet chewing gum based on alginate soft capsules | |
| CN107595871A (en) | Compound preparation containing ivermectin and preparation method thereof | |
| CN107753498A (en) | Compound ivermectin tablet and preparation method thereof | |
| DE60023119T2 (en) | COMPOSITIONS FOR THE ADMINISTRATION OF A CYCLOOXYGENASE-2 HEMMER TO ANIMALS | |
| CN107753437A (en) | A kind of new Tilmicosin pre-mixing agent and preparation method and application | |
| CN1874759A (en) | Process for producing coated preparation having relieved unpleasantness | |
| JP2019514991A (en) | Method for producing molded body for administration to animals | |
| RU2290830C2 (en) | Feed for sows | |
| CN108478588B (en) | Tilmicosin slow-release enteric solvent and preparation method thereof | |
| CN106727304B (en) | A kind of Fenbendazole suspension and preparation method thereof | |
| CN1072933C (en) | Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof | |
| CN105560189A (en) | Florfenicol slow-release dispersoid and preparation method thereof | |
| KR101688093B1 (en) | The composition of ivermectin chewable tablet and method for manufacturing thereof | |
| CN105147641B (en) | A kind of AVM gastric floating capsule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191112 |
|
| RJ01 | Rejection of invention patent application after publication |