CN110431143A - 杂芳基并嘧啶酮类衍生物及其制备方法和用途 - Google Patents

杂芳基并嘧啶酮类衍生物及其制备方法和用途 Download PDF

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CN110431143A
CN110431143A CN201880018956.0A CN201880018956A CN110431143A CN 110431143 A CN110431143 A CN 110431143A CN 201880018956 A CN201880018956 A CN 201880018956A CN 110431143 A CN110431143 A CN 110431143A
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heteroaryl
cycloalkyl
aryl
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CN110431143B (zh
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吕贺军
关东亮
白骅
陈明孝
王景录
钱林
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Zhejiang Hisun Pharmaceutical Co Ltd
Shanghai Aryl Pharmtech Co Ltd
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Zhejiang Hisun Pharmaceutical Co Ltd
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Abstract

本发明涉及式(I)所示的杂芳基并嘧啶酮类衍生物、其制备方法及其作为治疗剂的用途，特别是作为乙酰辅酶A羧化酶(ACC)抑制剂的用途，其中式(I)中的各取代基的定义与说明书中的定义相同。

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PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201880018956.0A 2017-03-24 2018-03-23 杂芳基并嘧啶酮类衍生物及其制备方法和用途 Active CN110431143B (zh)

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CN2017101825306 2017-03-24
CN201710182530 2017-03-24
PCT/CN2018/080117 WO2018171698A1 (zh) 2017-03-24 2018-03-23 杂芳基并嘧啶酮类衍生物及其制备方法和用途

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CN110431143A true CN110431143A (zh) 2019-11-08
CN110431143B CN110431143B (zh) 2022-08-12

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US10759812B2 (en) 2017-01-22 2020-09-01 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
JP2022513101A (ja) * 2018-11-20 2022-02-07 中国医▲薬▼研究▲開▼▲発▼中心有限公司 スピロ環系化合物及びその医薬用途
WO2021000242A1 (zh) * 2019-07-02 2021-01-07 广东东阳光药业有限公司 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用
US20240083908A1 (en) 2020-12-24 2024-03-14 Modulus Discovery, Inc. Tetrahydrothienopyrimidinesulfonamide compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2014182945A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2014182943A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2014182950A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2017091617A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
WO2017091600A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
WO2017091602A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2014182945A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2014182943A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2014182950A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2017091617A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
WO2017091600A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
WO2017091602A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof

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WO2018171698A1 (zh) 2018-09-27

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