CN110403579A

CN110403579A - A kind of pulse transit parameter measurement system and method

Info

Publication number: CN110403579A
Application number: CN201810404068.4A
Authority: CN
Inventors: 庄少春; 叶飞; 陈仁库
Original assignee: Shenzhen Dama Technology Co Ltd
Current assignee: Oufeikang Technology Shenzhen Co ltd
Priority date: 2018-04-28
Filing date: 2018-04-28
Publication date: 2019-11-05
Anticipated expiration: 2038-04-28
Also published as: CN110403579B

Abstract

The embodiment of the invention discloses a kind of pulse transit parameter measurement system and methods.This method comprises: obtaining the first vibration information of supine subject from the first fibre optical sensor by one or more processors, first fibre optical sensor is configured as being placed under the corresponding dorsal area of fourth dorsal vertebra body of the supine subject；By one or more of processors, the second vibration information of the supine subject is obtained from the second fibre optical sensor, second fibre optical sensor is configured as being placed under the corresponding lumbar region of fourth lumbar vertebra body of the supine subject；Pass through one or more of processors, the first haemodynamics relevant information is generated based on first vibration information, the second haemodynamics relevant information is generated with based on second vibration information, and then determines the aortic pulse wave conduction time of the supine subject.

Description

A kind of pulse transit parameter measurement system and method

Technical field

This application involves a kind of pulse transit parameter measurement system and method more particularly to a kind of non-invasive pulse waves Conduction parameter measuring system and method.

Background technique

Statement herein only provides background information related with the application, without inevitably constituting the prior art.

Worldwide, cardiovascular and cerebrovascular disease is the major reason for leading to morbidity with death, and cardiovascular and cerebrovascular disease Incidence and mortality is related with arterial vascular lesion.For example, angina pectoris, myocardial infarction are related to coronary artery pathological changes, brain Stroke is related to cerebral artery disease, and intermittent claudication is related to lower extremity artery pathology.Two kinds of Main Morphologies of arterial disease include Structural lesions and functional lesion, structural lesions show as angiemphraxis, such as atherosclerosis, functional lesion table It is now the variation of vascular function, such as vascular sclerosis.Wherein, the change of arterial blood tube wall elasticity is that various cardiovascular events occur With the basis of development.

The contraction and diastole of cardiac cycle, can not only cause the change of blood flow velocity and flow in arteries, also It can produce the pulse wave propagated along vascular wall.Pulse wave conduction speed (Pulse Wave Velocity, PWV) and arterial blood Tubular elastic is related, and the usual bigger pulse wave conduction speed of blood vessel hardness is also faster, therefore can pass through measurement pulse transit speed It spends to assess the extent of elasticity of artery.

Summary of the invention

The technical problem to be solved by the embodiment of the invention is that being detected for prior art cardiovascular disease relevant Technical problem provides a kind of non-invasive pulse wave conduction parameter measuring system and method.

In order to solve the above-mentioned technical problem, on the one hand, the embodiment of the invention provides a kind of pulse transit parameter measurements Method, comprising: the first vibration information of supine subject is obtained from the first fibre optical sensor, first fibre optical sensor is placed in institute It states under the corresponding dorsal area of fourth dorsal vertebra body of supine subject；The of the supine subject is obtained from the second fibre optical sensor Two vibration informations, second fibre optical sensor are placed under the corresponding lumbar region of fourth lumbar vertebra body of the supine subject； The first haemodynamics relevant information is generated based on first vibration information, and generates second based on second vibration information Haemodynamics relevant information；Determine that the aorta petal of the supine subject is beaten based on the first haemodynamics relevant information ETAD expected time of arrival and departure, and determine based on the second haemodynamics relevant information the pulse wave arrival time of the supine subject；And base In the aorta petal opening time and the pulse wave arrival time, the aortic pulse wave conduction of the supine subject is determined Time.

Preferably, first fibre optical sensor or the second fibre optical sensor include: an optical fiber, are arranged in substantially upper Structure in a plane；Light source is coupled with one end of one or more optical fiber；Receiver, with an optical fiber The other end coupling, for perceiving the variation of the luminous intensity by the optical fiber；With a clathrum, by the net for being provided with opening Eye composition, wherein the clathrum is contacted with the optical fiber surface.

It is preferably based on first vibration information and generates the first haemodynamics relevant information, and be based on described second Vibration information generates the second haemodynamics relevant information, further comprises: to first vibration information and second vibration Dynamic information is filtered respectively, scales to generate the first haemodynamics relevant information letter related to the second haemodynamics Breath.

Be preferably based on the first haemodynamics relevant information determine the supine subject aorta petal open when Between, further comprise: second-order differential operation is carried out to the first haemodynamics relevant information；After second-order differential operation The waveform diagram of first haemodynamics relevant information carries out signature search and determines the top in a cardiac cycle；With based on institute State the aorta petal opening time that top determines the supine subject.

Preferably, the method further includes: obtain first fibre optical sensor and second fibre optical sensor Between along Human Height direction distance and generate aortic pulse wave conduction distance；With by one or more of processors, Distance and the aortic pulse wave conduction time are conducted based on the aortic pulse wave, determines aortic pulse wave conduction speed Degree.

Preferably, the method further includes: send the aortic pulse wave conduction time and the active affectionately At least one of wave conduction of velocity of fighting arrives one or more output devices.

On the other hand, the present invention also provides a kind of pulse transit parameter measurement systems, comprising: the first Fibre Optical Sensor Device is placed in the fourth dorsal vertebra body near zone of supine subject, for obtaining the first vibration information of the supine subject；Second light Fiber sensor is placed in the fourth lumbar vertebra body near zone of the supine subject, for obtaining the second vibration of the supine subject Information；One or more processors；With one or more memories, one or more of memories are stored with instruction, work as institute It states when instruction is executed by one or more of processors and realizes any one method described above.

Another aspect, the present invention also provides a kind of pulse transit parameter measuring apparatus, comprising: ontology, the ontology For lying down for supine subject, the ontology includes upper cover and lower cover, and the ontology includes dorsal area and lumbar region；First Fibre optical sensor, first fibre optical sensor are placed in the dorsal area of the ontology, for obtaining the of the supine subject One vibration information；With the second fibre optical sensor group, including two or more fibre optical sensors, the second fibre optical sensor group is set In the lumbar region of the ontology, for obtaining the second vibration information of the supine subject；Wherein, the upper cover and it is described under First fibre optical sensor and the second fibre optical sensor group are coated on interior by lid.

Preferably, described device further comprises neckpillow, and the neckpillow is set on the upper lid, for lying on the back described in confession The neck pillow of object is leaned on to ensure that the supine subject is in measurement position.

Preferably, described device further comprises shoulder blocks, and the shoulder blocks are set on the upper lid, for supplying The shoulder of the supine subject is against to ensure that the supine subject is in measurement position.

Preferably, the ontology further includes limbic areas, and described device further comprises foot's block, foot's block It is set to the limbic areas of the upper cover, the foot or shank for supplying the supine subject are against to ensure the supine subject In measurement position.

Preferably, the housing cover can use stereochemical structure, including a human body outline concave structure is to ensure It states supine subject and is in measurement position.

Preferably, two or more fibre optical sensors in the second fibre optical sensor group are along the ontology longitudinal axis Arrangement.

Preferably, the fibre optical sensor includes: an optical fiber, is arranged in the structure being located substantially in a plane； Light source is coupled with one end of one or more optical fiber；Receiver is coupled with the other end of an optical fiber, for feeling Know the variation of the luminous intensity by the optical fiber；With a clathrum, the mesh by being provided with opening is formed, wherein the net Compartment is contacted with the optical fiber surface.

The implementation of the embodiments of the present invention has the following beneficial effects: the aorta of human body navigates within the thoracic cavity of human body, abdominal cavity In, it is not body surface shallow artery, the method for the pulse transit parameter of traditional measurement body surface shallow artery is not particularly suited for measurement master The pulse transit parameter of artery.Using the method for measurement human aortic pulse transit parameter provided by the invention, test Person, which only needs to lie on measuring device, to be measured, and measure without directly contact human body, and have and survey Accuracy of measurement height, advantage easy to operate, can greatly improve the comfort level of tester, and it is each to be widely portable to hospital and family etc. Kind scene.

Detailed description of the invention

Technical solution in ord to more clearly illustrate embodiments of the present application, below will be to required use in embodiment description Attached drawing be briefly described.It should be evident that drawings in the following description are only some embodiments of the invention, for this It, without creative efforts, can also according to these attached drawings will be of the invention for the those of ordinary skill in field Applied to other similar scenes.Unless explaining obviously or separately from language environment, identical label represents identical knot in figure Structure and operation.

Fig. 1 is a kind of schematic diagram of pulse transit parameter measurement system according to some embodiments of the application；

Fig. 2 is the production principle schematic diagram of pulse wave；

Fig. 3 is the measuring principle schematic diagram of aortic pulse wave conduction parameter；

Fig. 4 is the structural block diagram of the calculating equipment according to some embodiments of the application；

Fig. 5 is the structural schematic diagram of the sensing device according to some embodiments of the application；

Fig. 6 is the position view of the sensing device according to some embodiments of the application；

Fig. 7 is the flow chart of the pulse transit measurement method of parameters according to some embodiments of the application；

Fig. 8 is the signal waveforms of an object according to some embodiments of the application；

Fig. 9 is the schematic diagram of the sensing device according to some embodiments of the application；

Figure 10 is the schematic diagram of the register guide according to some embodiments of the application；With

Figure 11 is the schematic diagram of the register guide according to other embodiments of the application.

Specific embodiment

As shown in the application and claims, unless context clearly prompts exceptional situation, " one ", "one", " one The words such as kind " and/or "the" not refer in particular to odd number, may also comprise plural number.It is, in general, that term " includes " only prompts to wrap with "comprising" Include clearly identify the step of and element, and these steps and element do not constitute one it is exclusive enumerate, method or apparatus It may also include other step or element.

Fig. 1 is a kind of schematic diagram of pulse transit parameter measurement system 100 according to some embodiments of the application.Such as figure Shown in 1, pulse transit parameter measurement system 100 may include a sensing device 101, a network 103, a server 105, a storage device 107 and an output device 109.

Sensing device 101 can be configured as the vibration information for obtaining object 102.In some embodiments, sensing device 101 can be vibration sensing sensor, such as acceleration transducer, velocity sensor, displacement sensor, pressure sensor, answer Become sensor, strain gauge or be physical quantity equivalence to be converted based on acceleration, speed, displacement or pressure One of sensor (such as electrostatic charge sensitive sensor, inflatable jogging sensor, radar sensor etc.) is a variety of.One In a little embodiments, strain transducer can be fibre optic strain sensor.In some embodiments, sensing device 101 can also wrap Temperature sensitive sensor, such as infrared sensor are included, to obtain the body temperature information of object.Sensing device 101 is configurable to put It is placed on the beds of various models such as medical bed, nursing bed where object 102.Object 102 can be carry out vital sign parameter signals The life entity of monitoring.In some embodiments, object 102 can be patient in hospital and be also possible to by caregiver, such as old Person, prisoner or other people etc..The vibration information for the object 102 that sensing device 101 can will acquire is passed by network 103 It is defeated to carry out subsequent processing to server 105.In some embodiments, the vibration information that sensing device 101 obtains is after treatment Vital sign parameter signals of object, such as cardiac rate, respiratory rate, body temperature etc. can be calculated.In some embodiments, sensing dress After treatment, the pulse transit parameter of object, such as pulse transit can be calculated in the vibration information for setting 101 acquisitions Time (Pulse Wave Transit Time, PTT), pulse wave conduction speed PWV.Sensing device 101 can also will acquire Vibration information be transferred to output device 109 and exported, such as the waveform diagram for utilizing display to show vibration information.Sensing dress The vibration information for setting the object 102 that 101 can also will acquire is transferred to storage device 107 by network 103 and is stored, example It such as, may include multiple sensing devices in system 100, the vibration information for multiple objects that multiple sensing devices obtain can transmit It is stored to storage device 107, a part as customer data.

The exchange of information may be implemented in network 103.In some embodiments, pulse transit parameter measurement system 100 Component part (i.e. sensing device 101, network 103, server 105, storage device 107, output device 109) can pass through network 103 carry out mutual information transmit-receive.For example, sensing device 101 can pass through the life for the object 102 that network 103 will acquire Life sign coherent signal is stored to storage device 107.In some embodiments, network 103 can be single network, such as wired Network or wireless network can also be the combination of multiple network.Network 103 can include but is not limited to local area network, wide area network, be total to With network, dedicated network etc..Network 103 may include multiple network access point, such as wirelessly or non-wirelessly access point, base station or net Network access point makes the other components of pulse transit parameter measurement system 100 can connect network by the above access point 103 and pass through network transmission information.

Server 105 is configured as processing information.For example, server 105 can receive object 102 from sensing device 101 Vibration information, and from vibration information extract haemodynamics coherent signal, further to haemodynamics coherent signal The pulse transit parameter of object 102 is obtained after being handled.In some embodiments, server 105 can be single service Device is also possible to a server farm.Server farm can be concentrating type, be also possible to distributed (namely take Business device 105 can be a distributed system).In some embodiments, server 105 can be local or long-range 's.For example, server 105 can be stored in storage device 107, sensing device 101, and/or output dress by network 103 Set the data in 109.For another example, server 105 can directly with sensing device 101, storage device 107, and/or output device 109 connections are to carry out data storage.In some embodiments, server 105 can also be deployed in cloud platform, and cloud platform can be with Including but not limited to public cloud, private clound, mixed cloud etc..In some embodiments, server 105 shown in Fig. 4 can be counted It calculates and implements in equipment 400.

Storage device 107 is configured as storing data and instruction.In some embodiments, storage device 107 may include But be not limited to random access memory, read-only memory, programmable read only memory etc..Storage device 107, which can be, utilizes electric energy side The equipment that formula, magnetic energy mode, optical mode etc. store information, such as hard disk, floppy disk, core memory, CD, DVD etc..It mentions above And storage equipment only list some examples, the storage equipment that storage device 107 uses is not limited thereto.Storage device 107 can store the vibration information of the object 102 of the acquisition of sensing device 101, can be passed through with storage server 105 to vibration information Data of crossing that treated, such as the vital sign information (respiratory rate, heart rate) of object 102.In some embodiments, storage device 107 can be a component part of server 105.

Output device 109 is configured as output data.In some embodiments, output device 109 can be by server 105 The vital sign parameter signals generated after processing are exported, and the way of output includes but is not limited to graphical display, number is shown, voice is broadcast Report, braille one of are shown etc. or a variety of.Output device 109 can be display, mobile phone, tablet computer, projector, can wear Wear one of equipment (wrist-watch, earphone, glasses etc.), Braille display etc. or a variety of.In some embodiments, output device 109 can export with the vital sign parameter signals (such as respiratory rate, heart rate etc.) of real-time displaying object 102, in further embodiments Device 109 can a report of non real-time display, this report is the measurement result of object 102 within a preset period of time, for example, with Per minute rhythm of the heart result and per minute respiratory rate monitoring result of the family in time for falling asleep section.In some embodiments, defeated Device 109 can also export early warning out, and prompting mode includes but is not limited to audio alarm, vibration alarm, picture display police The modes such as report.For example, object 102 can be the patient guarded, output device 109 can be the display screen in nurse station, defeated The result that device 109 is shown out can be real-time heart rate, real-time respiratory rate etc., when heart rate respiratory rate occur it is abnormal (such as more than Threshold value is widely varied within a preset period of time) when, output device 109 can sound an alarm sound to prompt medical care Personnel, medical staff can carry out rescue etc. in time to patient.In further embodiments, output device 109 can be doctor Portable communication equipment (such as mobile phone), when the vital sign abnormalities of object 102, the one of one or more doctors' carryings A or multiple output devices 109 can receive warning information, the push mode of warning information can be according to terminal device with it is right It is pushed as the distance between 102.

It should be understood that the application scenarios of the system and method for the application are only some examples or implementation of the application Example, for those of ordinary skill in the art, without creative efforts, can also be according to these attached drawings The application is applied to other similar scene.Pulse transit parameter measurement system 100 can use in home scenarios, sensing Device 100 can be placed on average family bed, when object 102 is (such as old elder, the people with cardiovascular disease, postoperative Convalescent people) when being in sleep state in night, sensing device 101 can obtain continuously or in the way of predetermined or need The vibration information of object, then by the vibration information of 103 sending object of network (can send in real time, can also be in pre- timing Carving such as the next morning sends the total data in previous evening) to being handled on Cloud Server 105, Cloud Server 105 can be with By treated, information (such as heart rate per minute, respiratory rate per minute, aorta PWV) is sent to terminal 109, and terminal 109 can Be object 102 family doctor computer, family doctor can be according to the information evaluation object of object 102 after treatment 102 physical condition, rehabilitation situation etc..

It should be noted that above description is only the specific embodiment of the application, it is not considered as unique reality Apply example.For one of skill in the art, after understanding the contents of the present invention and principle, all may without departing substantially from In the case where the principle of the invention, structure, various modifications and variations in form and details are carried out, but these modifications and variations are still Within the scope of the claims of the present invention.In some embodiments, server 105, storage device 107 and output device 109 may be implemented as an equipment and realize respective function.For example, pulse transit parameter measurement system 100 can wrap Include a sensing device and a computer.Wherein, sensing device can be directly connected with computer by cable, can also be led to It crosses network to be connected with computer, which may be implemented the institute of above-mentioned server 105, storage device 107 and output device 109 It is functional, execute the functions such as data processing, storage, display.In further embodiments, pulse transit parameter measurement system 100 may include a sensing device and an integrated circuit, and the integrated circuit and sensing device become one (such as integrated In a cushion), which connects a display screen, realize the function of above-mentioned server 105 and storage device 107, Display screen realizes the functions such as data processing, storage and display as output device 109.

Fig. 2 is the production principle schematic diagram of pulse wave.As shown in Fig. 2, left ventricle 201 and aorta 203 pass through aorta Valve 205 is connected.Left ventricle 201 contraction reach certain pressure value aorta posterior valve 205 open (Aortic Valve Opening, AVO), blood is injected in aorta 203 from left ventricle 201, and since blood vessel is elastic pipeline, blood is injecting aorta Shi Huikuo Aorta wall is opened, this beating can be propagated along active blood vessel wall, form pulse wave 207.Haemodynamics (Hemodynamics) what is studied is the mechanics that blood flows in cardiovascular system, is deformation and the flowing with blood and blood vessel For research object.The generation and conduction of pulse wave are related with blood flow and blood vessel distortion, belong to pair of Hemodynamics Study As.Pulse wave 207 is related to the blood vessel elasticity of aorta 203 along the conduction of velocity of aorta, therefore can be passed by pulse wave Speed PWV is led to assess the stiff degree of blood vessel.

Fig. 3 is the measuring principle schematic diagram of aortic pulse wave conduction parameter.As shown in figure 3, aorta can be divided into liter Aorta, the arch of aorta and descending aorta, wherein aorta ascendens rises from left ventricle aortic orifice, continues to front upper right diagonal in master The arch of aorta issues truncus brachiocephalicus artery, left common carotid artery and left subclavian artery, truncus brachiocephalicus artery at the arch of aorta and locks in right chest Joint rear is divided into right common carotid artery and right subclavian artery.The arch of aorta connects aorta ascendens, makees to bend in presternal rear Shape bends towards left back, and bow row is migrated to left back as descending aorta to fourth dorsal vertebra body lower edge.Descending aorta is that aorta is longest One section, be left and right arteria iliaca communis in the punishment of fourth lumbar vertebra body.As it can be seen that the pulse wave of aorta segment rises from aorta starting point 301, conduct along aorta to aorta and left and right arteria iliaca communis crotch 303, therefore by aorta starting point 301 and aorta with The distance along aorta path between left and right arteria iliaca communis crotch 303 conducts distance, pulse wave as aortic pulse wave From the conduction of point 301 to the time of point 303 as aortic pulse wave conduction time, when aortic pulse wave conducts distance with conduction Between ratio as aortic pulse wave conduction of velocity (aortic PWV, aPWV).

Fig. 4 is the structural block diagram of the calculating equipment 400 according to some embodiments of the application.In some embodiments, Fig. 1 Server 105, storage device 107, and/or output device 109 can be implemented on calculating equipment 400.For example, server 105 It can implement on calculating equipment 400 and be configured as executing the function of server 105 described herein.In some implementations In example, calculating equipment 400 can be special purpose computer, only describe a server, this field for convenience, in Fig. 1 Those of ordinary skill is it should be understood that computing function relevant to pulse transit parameter measurement also can be implemented in multiple tools Have in the calculating equipment of identity function to disperse computing load.

Calculating equipment 400 may include a communication port 401, a processor (Central Processing Unit, CPU) 403, a memory 405 and a bus 407.Communication port 401 is configured as setting by network with other It is standby to carry out data exchange.Processor 403 is configured for data processing.Memory 405 is configured for data and instruction Storage, memory 405 can be read only memory ROM, random-access memory RAM, the various forms of storages such as hard disk Disk Device.Bus 407 is configured for calculating the data communication between 400 inside of equipment.In some embodiments, equipment 400 is calculated It can also include input/output port 409, input/output port 409 is configured as that data is supported to output and input.For example, other Personnel can use input equipment (such as keyboard) and pass through 409 input data of input/output port to calculating equipment 400.Calculating is set Standby 400 can also output data to output equipment such as display etc. by input/output port 409.

It should be understood that only describing a processor 403 herein for convenience, it should be appreciated that calculating is set Standby 400 may include multiple processors, the operation executed by a processor 403 or method can be combined by multiple processors or It executes respectively.For example, a processor 403 described herein can execute step A and step B, it should be appreciated that step A and step B can be common by multiple processors or be executed respectively, such as by first processor execution step A and by second processing Device executes step B, or executes step A and step B jointly by first processor and second processor.

Fig. 5 is the structural schematic diagram of the fibre-optical sensing device 500 according to some embodiments of the application.As shown in figure 5, optical fiber Sensing device 500 is a kind of strain transducer, is filled when external force is applied on fibre-optical sensing device 500, such as by Fibre Optical Sensor When setting 500 and being placed in below the human body that lies low, when object is in quiescent condition, breathing, heartbeat of human body etc. will lead to human body body Body generates vibration, and the body vibration of human body can cause the bending of optical fiber 501, and fibre-optical bending makes to send out by the parameter of the light of optical fiber Changing, such as luminous intensity change.The variation of luminous intensity can be used to characterize the body vibration of human body after treatment.

Fibre-optical sensing device 500 may include an optical fiber 501, a clathrum 503, under a upper cover 507 and one Lid 505.Wherein, one end of optical fiber 501 connects light source 509, and light source 509 can be LED light source, light source 509 and light source drive 511 connections, light source drive 511 are configured as the switch and energy level of control light source.The other end and receiver 513 of optical fiber 501 Connection, receiver 513 are configured as receiving the optical signal transmitted by optical fiber 501, and receiver 513 connect with amplifier 515, puts Big device 515 is connect with analog-digital converter 517, and the optical signal received can be carried out analog-to-digital conversion, conversion by analog-digital converter 517 For digital signal.Light source drive 511, analog-digital converter 517 are connected with control processing module 519.Control 519 quilt of processing module Be configured to carry out signal control and signal processing, for example, control processing module 519 can control the work of light source drive 511 with Light source 509 is driven to shine, control processing module 519 can also receive data from analog-digital converter 517, after handling data Make the requirement of the various wirelessly or non-wirelessly network data transmissions of data fit, to set by wirelessly or non-wirelessly network transmission to other It is standby, server 105, storage device 107, and/or the output device 109 of example as shown in figure 1.Control processing module 519 can also be controlled The sample rate of molding number converter 517 makes it have different sample rates according to different demands.In some embodiments, light source drives Dynamic device 511, receiver 513, amplifier 515, analog-digital converter 517 and control processing module 519, which can merge, is embodied as one Module is functional to execute.

Optical fiber 501 can be multimode fibre, can be single mode optical fiber.The arrangement mode of optical fiber can be it is of different shapes, Such as serpentine configuration, the shape as shown in 501 in Fig. 5.In some embodiments, the arrangement mode of optical fiber 501 can also be U-shaped knot Structure.The arrangement mode of optical fiber 501 can also be cyclic structure in some embodiments, and as shown in 521, the cyclic structure is by one Optical fiber is arranged in the multiple equal-sized rings being located substantially in a plane and is formed, wherein each ring in cyclic structure It partly overlaps with adjacent ring and lateral shift.Each fiber optic loop can form parallel four side substantially with circular edge The structure (such as rectangle, square etc.) of shape, not bending sharply.In some embodiments, annular fiber structure can be with Including round or ellipse structure.In further embodiments, the cyclic structure can also form no sharply curved do not advise Then shape.

Clathrum 503 is made of any suitable material of the repeat patterns with through hole, in some embodiments, net Lattice are made of the fiber to interweave, for example, polymer fiber, natural textile fibers, compound fabric fiber or other fibers.When optical fiber passes Induction device 500 is placed in below subject's body, and object will apply external force to fibre-optical sensing device 500, and clathrum 503 can make originally The external force dispersion of a certain position on optical fiber can be applied to be distributed on the optical fiber around the position.Optical fiber 501 occurs Micro-bend, the parameter (such as light intensity) of light for causing optical fiber 501 to transmit changes, receiver 513 can receive change after Light, and by the processing and determination of the progress light variable quantity of control processing module 519.Optical fiber 510 generates curved under external force application Song amount depends on external force, fibre diameter, the diameter of Gitterfasern, mesh openings size, by the way that fibre diameter, Gitterfasern is arranged The different parameters combination of diameter, mesh openings size, can make the amount of bow of the optical fiber when external force applies different, pass optical fiber Induction device 500 has the different sensitivity to external force.

Upper cover 507 and lower cover 505 can use silica gel material, be configured around the week of optical fiber 501 and clathrum 503 It encloses, can protect optical fiber 501, while external force can also be dispersed, external force is dispersed along point of force application.Upper cover 507, optical fiber 501, Clathrum 503 and lower cover 505 can fit into an entirety, such as are integrated using bonded with silica adhesive, to make light Fiber sensing equipment 500 forms a piece of sensor mat.The width and/or length of sensor mat can be different according to optical fiber arrangement mode and Change, when using cyclic structure arrangement, the width of sensor mat can be other suitable width of 6cm or 6cm or more, example It such as can be 8cm, 10cm, 13cm or 15cm.The length of sensor mat can change according to different usage scenarios, for example, needle Crowd in normal range (NR) is in stature, the length of sensor mat can be between 30cm to 80cm, such as 50cm, be also possible to Other are suitably sized, and wherein the length of 45cm can be adapted for most people.In some embodiments, the thickness of sensor mat can Think 1mm-50mm, it is preferred that with a thickness of 3mm.In some embodiments, the width of sensor mat and length can be other rulers It is very little, various sizes of sensor can be chosen according to different test objects, such as test object can be according to age bracket, body High, weight divides group, and different groups is corresponding with various sizes of sensor.In some embodiments, when optical fiber uses U When shape structure, the width of sensor mat might be less that 6cm, such as can be 1cm, 2cm or 4cm.

In some embodiments, fibre-optical sensing device 500 can also have a housing (being not shown in Fig. 5), and housing will Upper cover 507, clathrum 503, optical fiber 501 and lower cover 505 wrap up, and housing can use waterproof and oilproof material, for example, by using hard Matter plastics.In further embodiments, fibre-optical sensing device 500 can also have a support construction (being not shown in Fig. 5), branch Support structure can be rigid structure, such as hardboard, rigid plastic sheet, plank etc., and support construction can be placed in optical fiber 501 and lower cover Between 505, support is provided to optical fiber 501, when external force is applied on optical fiber 501, support construction can make the change of optical fiber layer Shape is sprung back faster, and the rebound time is shorter, therefore optical fiber layer can capture the signal of higher frequency.

Fig. 6 is the position view of the sensing device according to some embodiments of the application.As shown in fig. 6, sensing device 600 It can include but is not limited to fibre optical sensor 601 and fibre optical sensor 603.In some embodiments, fibre optical sensor 601 and light Fiber sensor 603 can use the structure of fibre-optical sensing device 500.

In order to clearly illustrate the position of partes corporis humani position, the placement position of correlation and sensing device in this application The relationship with partes corporis humani's interdigit is set, introduces human anatomy coordinate system herein, human body standard position is divided into orthostatic body position and faces upward Sleeping position, by taking supine body position as an example, as shown in fig. 6, X-axis is center horizontal axis, Y-axis is median sagittal axis, and Z axis is that center is vertical Axis, origin O are located at the midpoint of phalanx joint upper limb, and wherein YZ plane is median sagittal plane, and human body is divided into left and right two parts, XZ Plane is center coronal-plane, and human body is divided into front and back two parts, and X/Y plane is origin cross section, and human body is divided into two up and down Point.The front of human body described herein, rear portion, top, lower part, left part, right part are carried out on the basis of anatomical coordinates system Description.

In some embodiments, after fibre optical sensor 601 can be placed on the corresponding body of aorta starting point of object 102 Under portion region, about under the corresponding back body surface area of the fourth dorsal vertebra body of human body.Fibre optical sensor 603 can be placed Under the aorta body Background Region corresponding with left and right arteria iliaca communis crotch of object 102, about in human body the 4th Under the corresponding back body surface area of lumbar vertebral body.According to different measurement objects and/or different application scenarios, fibre optical sensor 601 and the length and width of fibre optical sensor 603 can be selected according to actual needs, such as length (along X-axis) can be Between 30cm to 80cm, width (along Y-axis) be can be between 1cm to 20cm, and it is suitably sized to be also possible to other.In some realities It applies in example, fibre optical sensor 601 and fibre optical sensor 603 are two independent sensors, and the placement location of the two respectively can be with Manual adjustment, for example, the height difference of different objects causes the length of aorta segment also different, therefore fibre optical sensor 601 Spacing distance between fibre optical sensor 603 can be adjusted with object height difference.In some embodiments, sensing device 600 can also include an ontology, and the ontology for object for lying down, for example, ontology can be a cushion, cushion includes upper Lid and lower cover, upper cover and lower cover fitting are integrated, and fibre optical sensor 601 and fibre optical sensor 603 can be coated on by cushion The space interior that lid and lower cover are formed, and fix its position, wherein between fibre optical sensor 601 and fibre optical sensor 603 Interval can be can be preset according to actual needs, such as can be between 20cm to 80cm, and it is suitable to be also possible to other Distance.600 shapes and sizes of sensing device can be selected according to actual needs, for example, sensing device 600 can be four sides Shape can also be round or other suitable shapes.Different rulers can be arranged in sensing device 600 according to the height of usual crowd It is very little, such as the size of height 155cm-160cm crowd is suitble to be 40cm, it is set as No. S, is suitble to height 161cm-170cm crowd's Size is further added by certain distance, such as 3cm on the basis of can be No. S.In further embodiments, fibre optical sensor 601 and light Fiber sensor 603 is covered by cushion itself, and the position of any one fibre optical sensor can be fixed (such as by light Fiber sensor 601 is fixed), an activity space can be set in cushion itself, so that another fibre optical sensor (such as optical fiber passes Sensor 603) position it is adjustable.For example, a sliding rail is arranged in the inside of cushion, fibre optical sensor 603 is arranged In orbit, a control device is arranged outside cushion allows operator to control Fibre Optical Sensor by the control device The movement of device 603, such as control device are handles, and operator can for another example be controlled with the movement of hand-guided fibre optical sensor 603 Device processed is switch, and when control device is opening state, fibre optical sensor 603 is automatically according to preset speed direction or back Mobile from fibre optical sensor 601, when control device is closed state, fibre optical sensor 603 becomes stationary state.Wherein, it pads Sub- outside is also provided with scale mark, such as is arranged along sliding rail, so that optical fiber can be read directly in operator The distance between sensor 601 and fibre optical sensor 603 interval.

It should be understood that the application scenarios of the device of the application, system and method are only some examples of the application Or embodiment for those of ordinary skill in the art without creative efforts, can also be according to this The application is applied to other similar scene by a little attached drawings.For example, sensing device 101 can be not limited to fibre-optical sensing device 500 And the form of sensing device 600, to be suitable for other scenes.

Fig. 7 is the flow chart of the pulse transit measurement method of parameters according to some embodiments of the application.In some implementations In example, method 700 can pulse transit parameter measurement system 100 as shown in Figure 1 implement.For example, method 700 can store It is used as instruction set in storage device 107, and is executed by server 105, server 105 can be real on calculating equipment 400 It applies.

Step 711, processor 403 can obtain the first vibration information of supine subject from the first fibre optical sensor, described First fibre optical sensor is configured as being placed under the corresponding dorsal area of fourth dorsal vertebra body of the supine subject.In some realities It applies in example, supine subject can be hospital patient or by caregiver etc., is in back floating position, lies on sensing device 600.The One fibre optical sensor can be the fibre optical sensor 601 in sensing device 600, and fibre optical sensor 601 is placed in the master of supine subject Under the corresponding dorsal area of artery starting point, about under the corresponding dorsal area of fourth dorsal vertebra body.The first of supine subject Vibration information may include: human body vibration information, blood vessel shape caused by human body vibration information, heart contraction diastole caused by breathing The one or more of human body vibration information caused by becoming and the body movement information of human body.Wherein human body caused by heart contraction diastole Vibration may include human body vibration caused by heart contraction diastole itself, further include that the flowing of blood flow caused by heart contraction diastole is drawn The human body vibration risen, such as cardiac ejection cause blood to impact human body vibration caused by the arch of aorta.People caused by blood vessel deformation Body vibration, which can be cardiac ejection, causes aorta wall to expand to form pulse wave, and pulse wave conducts caused human body vibration along blood vessel It is dynamic.The body movement information of human body may include bending one's legs, lifting leg, turn, shake etc..Specifically, it will drive when human body respiration entire Body part based on body especially thoracic cavity abdominal cavity carries out rhythmic vibration, and human heart, which shrinks diastole, also will drive entirely Body vibration around body especially heart, left ventricle can impact the arch of aorta, heart to the moment blood that aorta penetrates blood A series of movement can also occur as a whole for the big vasculature part of itself and its connection, the body remoter apart from heart The vibration divided can be weaker, and pulse wave propagates the body part vibration where causing blood vessel along blood vessel, and blood vessel is thinner, centrifugation is dirty more Remote then herein body vibration is weaker.Therefore, when sensor is located under human body different location, the vibration that sensor obtains is believed Breath is the human body vibration information described above detected under this position, when the human body vibration information that position does not obtain simultaneously not yet Together.Aorta is the most thick artery of human body, is risen from left ventricle, is located at thoracic cavity abdominal cavity region, therefore when fibre optical sensor 601 is placed in When under the corresponding dorsal area of object fourth dorsal vertebra body, due to being located near heart, above-mentioned several human body vibration information It can completely or partially be obtained and generate the first vibration information.As shown in figure 8, curve 821 is according to the application one implementation In example, certain object that a fibre optical sensor 601 under the corresponding dorsal area of Mr. Yu's object fourth dorsal vertebra body obtains is placed The first vibration information waveform diagram, wherein horizontal axis indicate the time, the longitudinal axis indicate be normalized after object first Vibration information, dimensionless.

Step 713, processor 403 can obtain the second vibration information of the supine subject from the second fibre optical sensor, Second fibre optical sensor is configured as being placed under the corresponding lumbar region of fourth lumbar vertebra body of the supine subject.One In a little embodiments, the second fibre optical sensor can be the fibre optical sensor 603 in sensing device 600, and fibre optical sensor 603 is placed in It is about corresponding in fourth lumbar vertebra body under the descending aorta of supine subject waist location corresponding with left and right arteria iliaca communis crotch Lumbar region under.Since fibre optical sensor 603 is located at object aorta end, belong within abdominal cavity, therefore it gets The second vibration information may include human body vibration caused by breathing caused human body vibration, heart contraction diastole, pulse wave edge Vibration caused by blood vessel is propagated.As shown in figure 8, curve 823 is to place Mr. Yu's object the 4th according in the application one embodiment The waveform of second vibration information of certain object that a fibre optical sensor 603 under the corresponding lumbar region of lumbar vertebral body obtains Figure, wherein horizontal axis indicates the time, and the longitudinal axis indicates the second vibration information of the object after being normalized, dimensionless.

Step 715, processor 403 can generate the first haemodynamics relevant information based on first vibration information, The second haemodynamics relevant information is generated with based on second vibration information.Haemodynamics (hemodynamics) research Be mechanics that blood flows in cardiovascular system, be the deformation and flowing with blood and blood vessel be research object.The application " the haemodynamics relevant information " of description refers to any information relevant to haemodynamics, can include but is not limited to, with blood The raw relevant information (such as the contraction diastole of heart causes to penetrate blood) of miscarriage, with the flow-related information of blood flow (such as heart stroke CO (cardiac output), left ventricular ejection impact the arch of aorta), information relevant to blood stream pressure (such as arterial contraction Pressure, diastolic pressure, mean arterial pressure), one or more of information relevant to blood vessel (such as blood vessel elasticity).Pulse transit Parameter, such as pulse wave conduction speed, it is not only related to blood vessel elasticity, also with the contraction of heart and diastole, left ventricular ejection blood It is related that liquid impacts the arch of aorta, therefore the measurement of pulse transit parameter is related to the acquisition of haemodynamics relevant information.One Exist in a little pertinent literatures and impacts (Ballistocardiogram, BCG) signal diligently to characterize people caused by heartthrob The a series of cycle movement of body, in the human body vibration information that vibration sensing sensor described herein obtains, heart contraction Human body vibration caused by diastole can also be represented as BCG signal.Haemodynamics relevant information described herein includes BCG Including signal.In some embodiments, the first vibration information obtained for fibre optical sensor 601 in step 711, processor Vibration caused by blood impact arch of aorta when 403 the first haemodynamics relevant informations to be generated may include left ventricular ejection Vibration information caused by dynamic and blood vessel deformation (i.e. pulse wave propagates caused vibration along blood vessel).Fibre optical sensor in step 713 In 603 the second vibration informations obtained, the second haemodynamics relevant information to be generated of processor 403 may include pulse wave Caused vibration is propagated along blood vessel.As shown in figure 8, curve 825 is processor 403 according to the first vibration letter shown in curve 821 The time domain waveform of the first haemodynamics relevant information generated is ceased, curve 827 is processor 403 according to 823 institute of curve The time domain waveform of the second vibration information shown the second haemodynamics relevant information generated, horizontal axis indicate the time.

In some embodiments, the first vibration information and the second vibration information that processor 403 can will acquire carry out one Series of processes is to generate the first haemodynamics relevant information and the second haemodynamics relevant information.First vibration information And/or second include more seed vibration informations (vibration, blood vessel caused by vibration, heart contraction caused by breathing in vibration information Vibration caused by deformation), processor 403 can carry out the filtering processing of different frequency range for different sub- vibration informations.For example, It is 1Hz hereinafter, the filtering side that processor 403 uses that processor 403, which can be set and breathe the filtering frequency range of caused vibration information, Method can include but is not limited to low-pass filtering, bandpass filtering, IIR (Infinite Impulse Response) filtering, FIR (Finite Impulse Response) filtering, wavelet filtering, zero phase bidirectional filtering, in fitting of a polynomial smothing filtering It is one or more, the first vibration information and/or the second vibration information can be filtered at least once.If vibration letter Power frequency interference signals are carried in breath, then can also design frequency filter and filter out industrial frequency noise.Processor 403 can also in time domain To be filtered in frequency domain to vibration information.Processor 403 can also according to dynamic range of signals to filtering and noise reduction after First/second vibration information zooms in and out to obtain first/second haemodynamics coherent signal.

Step 717, processor 403 can determine the supine subject based on the first haemodynamics relevant information Aorta petal opening time, and based on the second haemodynamics relevant information determine the supine subject pulse wave reach when Between.Vibration caused by blood flow impact arch of aorta when may include left ventricular ejection in the first haemodynamics relevant information, and Pulse wave propagates caused vibration along blood vessel.In cardiac cycle, aorta petal is opened, left ventricular ejection, and blood enters actively The generation time point of pulse wave is considered at the time of arteries and veins, the blood flow that left ventricle projects this moment can impact the arch of aorta, cause heart A series of movement occurs as a whole for the big vasculature part of itself and its connection, moves and generates so as to cause human body body Displacement.Due to the contraction diastole of cardiac cycle, human body displacement is also periodically to change, and this vibration information can lead to It crosses human skeleton, muscle etc. to be conducted, first be placed under the corresponding dorsal area of fourth dorsal vertebra body of supine subject Fibre optical sensor can capture this vibration information.Due to aorta petal open this event and sensor capture it is corresponding Time delay between this event of body vibration information is usually smaller, and about within 10ms, this time delay is subsequent It can choose and ignore in pulse transit parameter measurement, i.e., sensor is captured into human body vibration caused by aorta petal is opened The time of dynamic information as aorta petal opening time, also can choose and assign one to actually measured aorta petal opening time A correction factor is modified.Pulse wave is conducted along blood vessel, and vibration is conducted also with blood vessel, causes the vibration of human body, therefore After pulse transit reaches certain position on blood vessel, the vibration sensing sensor at the body position where the blood vessel can be caught Vibration information is received, therefore be placed in the second fibre optical sensor that supine subject fourth lumbar vertebra body corresponds under lumbar region to catch Receive the vibration information of pulse transit to aorta segment end (i.e. descending aorta and left and right arteria iliaca communis crotch).Equally The time delay that ground, pulse wave arrival time and the second fibre optical sensor capture between corresponding body vibration information is smaller, this A time delay can choose in subsequent pulse transit parameter measurement and ignore, i.e., sensor is captured pulse wave and arrived Up to human body vibration information caused by the end of aorta segment time as pulse wave arrival time, also can choose to practical survey The pulse wave arrival time obtained assigns a correction factor to be modified.

In some embodiments, it is related to be based on first haemodynamics can to execute following operation for processor 403 Information determines the aorta petal opening time of the supine subject.As shown in figure 8, being the first haemodynamics shown in curve 825 The time domain waveform of relevant information, processor 403 can carry out second-order differential operation to curve 825 and obtain curve 829.For 829 waveform diagram, processor 403 can carry out signature search to determine aorta petal opening characteristics point.Spy in signature search Sign can include but is not limited to wide wave crest, trough, wave, wave amplitude, maximum value minimum, maximum value, minimum value etc..In some realities It applies in example, peak search can be used by carrying out signature search to curve 829, with each period for a search range, at one The top searched in period is aorta petal opening time as aorta petal opening characteristics point, corresponding time. As shown in curve 829 in Fig. 8, in figure in first complete cardiac cycle, point 820 is aorta petal opening characteristics point.In In other embodiments, processor 403 can also directly carry out signature search to curve 825 to determine aorta petal opening characteristics Point, for example, search obtains the top peak J first, then when the peak J is corresponding with a cardiac cycle for a region of search Between before time range in search, search obtains minimum (peak AVO), corresponding as aorta petal opening characteristics point Time be aorta petal opening time.

In some embodiments, it is related to be based on second haemodynamics can to execute following operation for processor 403 Information determines the pulse wave arrival time of the supine subject.As shown in figure 8, being the second haemodynamics phase shown in curve 827 The time domain waveform of information is closed, processor 403 can carry out second-order differential operation to curve 827 and obtain curve 831.For 831 Waveform diagram, processor 403 can carry out signature search determine pulse wave reach characteristic point.Feature in signature search can be with Including but not limited to wave crest, trough, wave be wide, wave amplitude, maximum value minimum, maximum value, minimum value etc..In some embodiments, Peak search can be used by carrying out signature search to curve 831, with each period for a search range, be searched in one cycle The top that rope arrives reaches characteristic point as pulse wave, and the corresponding time is pulse wave arrival time.Such as curve in Fig. 8 Shown in 831, in figure in first complete cardiac cycle, point 822 is that pulse wave reaches characteristic point.

In some embodiments, the digital signal processing method that processor 403 can be equivalent by other essence, such as adopt With fitting of a polynomial smothing filtering, the information with progress second-order differential operation effects equivalent is obtained.

In some embodiments, the first vibration information of supine subject and the second vibration information continuously acquire, may The data waveform that can exist in some or certain several cardiac cycles is different from the data waveform of other cardiac cycles, this is aroused in interest at this time It may not be corresponding top that aorta petal opening characteristics point and pulse wave, which reach characteristic point, in period, may be by It floods, at this moment can give up the data of the cardiac cycle.

In some embodiments, processor 403 can receive user's input from one or more input units to determine State aorta petal opening time and the pulse wave arrival time of supine subject.For example, external input parameter can be medical staff Processing equipment 400 is input to by input/output port 409 using input equipment (such as mouse, keyboard).Medical staff be through Cross the ability that training has the judging characteristic point from vibration signal waveforms.For example, being directed to curve 825, medical staff can be artificial Waveform analysis, the first top in one cardiac cycle of selection are carried out, then toward same before the corresponding time of top Waveform minimum is found in a periodic regime, is labeled as aorta petal opening characteristics point, and demarcated using input equipment, example Characteristic point such as is selected using mouse, therefore the input of medical staff can be determined as aorta petal opening characteristics by processor 403 Point simultaneously obtains its corresponding time as aorta petal opening time automatically.

Step 719, processor 403 can be based on the aorta petal opening time and the pulse wave arrival time, really The aortic pulse wave conduction time of the fixed supine subject.In some embodiments, processor 403 can take any one heart (pulse wave arrival time subtracts aorta petal for aorta petal opening time in the dynamic period and the difference between pulse wave arrival time Opening time) it is used as aortic pulse wave conduction time.In some embodiments, processor 403 can select multiple weeks aroused in interest Phase, such as 20 cardiac cycle, calculate separately in each cardiac cycle aortic pulse wave conduction time (i.e. PTT1, PTT2 ... PTT20), it then averages as aortic pulse wave conduction time.In some embodiments, processor 403 can To choose fixed duration, such as 60 seconds, pulse wave translation time in the time in each cardiac cycle is calculated (i.e. PTT1, PTT2 ...), and be averaged as pulse wave translation time.In further embodiments, processor 403 can be with Automatic rejection pulse wave translation time data not in the reasonable scope and using the average value of other remaining data as pulse wave Conduction time.In further embodiments, processor 403 can also be by the pulse transit in all periods acquired in test Time is all calculated, and is averaged as pulse wave translation time.

Step 721, available first fibre optical sensor of processor 403 and second fibre optical sensor are along human body The distance in height direction conducts distance as the aortic pulse wave of the supine subject, is conducted based on the aortic pulse wave Distance and the aortic pulse wave conduction time, determine aortic pulse wave conduction of velocity.In some embodiments, the first light Fiber sensor and the second fibre optical sensor are independent equipment, and interval between the two can be with manual adjustment to adapt to different heights Test object.Aortic pulse wave conduction distance at this time can use labor measurement, such as medical staff utilizes tape, straight The rangings tools such as ruler, line with a scale measure the first fibre optical sensor and the second fibre optical sensor along Human Height direction Distance is used as pulse transit distance.In some embodiments, between the first fibre optical sensor and the second fibre optical sensor Every can be fixed, at this moment distance between the two can be used as preset parameter and be transferred to processor 403 in system initialization.In In some embodiments, the first fibre optical sensor and the second fibre optical sensor that processor 403 can directly will acquire are along human body The distance in height direction conducts distance as aortic pulse wave.In further embodiments, processor 403 can be to getting Distance along Human Height direction of the first fibre optical sensor and the second fibre optical sensor be modified, such as assign amendment system Number, can be added for another example with a constant, then conduct distance as aortic pulse wave.

In further embodiments, aortic pulse wave conduction distance can be estimated according to formula, for example, can incite somebody to action The parameters such as height, weight, the age of test object carry out data input, processor 403 by the input equipment of system 100 To estimate the pulse transit distance of test object according to formula.It is tested for example, processor 403 can be estimated according to following formula The aorta length of object, that is, aortic pulse wave conduct distance:

L=a+b* (age)+c* (height)+d* (weight)

Wherein, L indicate aorta length, by centimetre as unit of, the age as unit of year, height by centimetre as unit of, body Weight by kilogram as unit of.A states constant, and b, c, d are coefficients, can be according to the practical aorta length and each survey manually measured Age, height, weight of examination person etc. are fitted the numerical value that a, b, c, d is calculated, such as in some embodiments, and a can be with 0.18, c can be assigned a value of and can be assigned a value of 0.32, d that 0.08 can be assigned a value of by being assigned a value of -21.3, b.

Step 723, processor 403 can be sent in the pulse wave translation time and the pulse wave conduction speed extremely Few one is arrived one or more output devices.For example, pulse wave translation time can be sent to the output device in system 100 109 are exported.Output device 109 can be display equipment, such as mobile phone, can be with figure or text importing pulse transit Time.Output device 109 can be printing device, and the measurement report of pulse transit parameter is printed.Output device 109 It can be voice broadcast equipment, pulse transit parameter be subjected to voice output.In some embodiments, processor 403 can be with Pulse wave translation time and/or pulse wave conduction speed are sent to output device by wireless network, such as output device is Mobile phone.In further embodiments, processor 403 can be fast by pulse wave translation time and/or pulse transit by cable Degree is sent directly to output device, such as output device is display, can be connected by cable with sensing device.

In some embodiments, the step of method 700 can be executes in order, in further embodiments, method 700 the step of, can be executed sequentially, or be performed simultaneously.It is beaten for example, step 719 is based on the aorta petal After the completion of ETAD expected time of arrival and departure and the pulse wave arrival time determine pulse wave translation time, step 721, obtains first optical fiber and pass Aortic pulse wave of the distance as the supine subject between sensor and second fibre optical sensor along Human Height direction Distance is conducted, based on aortic pulse wave conduction distance and the aortic pulse wave conduction time, is determined actively affectionately It fights wave conduction of velocity and step 723, sends the pulse wave translation time to one or more output devices, can be simultaneously It executes.In addition, in some embodiments, method 700 can in the case where describing the spirit and scope of theme without departing from here To remove wherein one or more steps, for example, step 721 and/or step 723 can not execute, in further embodiments, Other operations can also be added in method 700.

Fig. 9 is the schematic diagram of the sensing device according to some embodiments of the application.As shown in figure 9, sensing device 900 can be with An including but not limited to ontology 901, the first fibre optical sensor 903, the second fibre optical sensor group 905 and register guide 907。

Refer to clearly demonstrate the first fibre optical sensor 903, the second fibre optical sensor group 905 and positioning in this application Show the mutual positional relationship of device 907 and the positional relationship with ontology 901, introduces corresponding coordinate herein and enter description. Sensing device 900 can be placed on bed or be placed directly on floor, therefore Z axis indicates the direction perpendicular to ground, deviates from Ground direction is positive direction, and X/Y plane is parallel to horizontal plane, and X-axis is along the width direction of sensing device 900, and Y-axis is along sensing device 900 length direction, origin O are located at the midpoint of one end point edge of sensing device 900.YZ plane divides sensing device 900 Left and right two parts.Along the y axis, up and down direction in contrast, such as the boundary of dorsal area and lumbar region can be indicated Line can be referred to as the lower edge of dorsal area, while be also the top edge of lumbar region.

Ontology 901 may include upper cover 911 and lower cover 913, and upper cover 911 and lower cover 913 are by 903 He of the first fibre optical sensor In second fibre optical sensor group 905 is coated on, upper cover 911 and lower cover 913 are integrated by suture or adhesive fitting.Ontology 901 can be in turn divided into dorsal area, lumbar region and limbic areas along the y axis.The size of ontology 901 can basis The figure and height of test object are selected, such as its length (along Y-axis) can be 190cm, and width can be 85cm, this Size is suitable for most people, is also possible to that other are suitably sized, is not intended to limit herein.Correspondingly, the dorsal area of ontology, The width (along X-axis) of lumbar region and limbic areas can also be selected with the figure and height of test object, for example, being applicable in It is back region field width 30cm in the size of most people, waist area field width 50cm is also possible to that other are suitably sized, herein It is not intended to limit.When object is lain on the back on sensing device 900, when being in back floating position, back, waist and lower limb are sequentially located at back region In domain, lumbar region and limbic areas, upper limb is located in dorsal area and lumbar region.Upper cover 911 and lower cover 913 can use Various material, such as cortex, cotton etc..

First fibre optical sensor 903 is located in dorsal area.First fibre optical sensor 903 can be fibre optical sensor can be with Using structure as shown in Figure 5.In some embodiments, as shown in figure 9, the length (along X-axis) of the first fibre optical sensor 903 can To be to be selected according to test object, such as can be 50cm, it is suitable for most people, width (along Y-axis) is also can root It is selected according to test object, such as can be 30cm, be suitable for most people, be also possible to that other are suitably sized, herein It is not intended to limit.When object is lain supine upon on sensing device 900, left and right body part is substantially symmetrical along Y-axis, shoulder top edge and back The top edge in portion region is aligned, and back is located in the dorsal area of ontology, and both legs close up naturally, and the lowering of both hands nature is in body two Side, at this point, the back of object is located on the first fibre optical sensor 903.First fibre optical sensor 903 is configured as obtaining object First vibration information.

Second fibre optical sensor group 905 may include two or more fibre optical sensors, two or more fibre optical sensors (905-1,905-2 ... 905-n) it can successively be arranged in lumbar region along the y axis.Y direction is referred to as ontology Y direction, X-direction are the X direction of ontology.Two or more fibre optical sensors can use structure as shown in Figure 5. In some embodiments, as shown in figure 9,6 fibre optical sensors can successively arrange along Y-axis, the width of each fibre optical sensor (along Y-axis) can be 1cm-20cm, and length (along X-axis) can be 10cm-80cm, be also possible to that other are suitably sized, herein It is not intended to limit.In further embodiments, the number of the fibre optical sensor in the second fibre optical sensor group 905 can be variation , when test object height is especially high, the number of fibre optical sensor can be increased, such as increase to 8 or more, so that When test object is lain on the back, the last one fibre optical sensor arranged along the y axis in the second fibre optical sensor group 905 can be located at When below the hipbone of test object.When object is lain supine upon on sensing device 900, left and right body part is substantially along Y-axis pair Claim, shoulder top edge is aligned with the top edge of dorsal area, and both legs close up naturally, the lowering of both hands nature in body two sides, at this point, The waist and buttocks of object are located in the lumbar region of sensing device.Second fibre optical sensor group 905 is configured as obtaining object The second vibration information, the second vibration information may include the human body vibration information that each sensor of waist detects.

Register guide 907 is configured as instruction and subtest object is rapidly lain in preferred measurement position.Such as Shown in Fig. 9, register guide 907 is a shoulder blocks, which can be fixedly disposed at the upper cover of ontology 901 On 911, for example, being linked together by suture with upper cover 911.In some embodiments, shoulder blocks can also be by detachable Mode connect with upper cover 911, for example, being connect with upper cover 911 by velcro.In further embodiments, register guide 907 may include two or more shoulder blocks, be the top view of three sensing devices as shown in Figure 10, wherein sensing device 1001 register guide may include two shoulder blocks 1011, be arranged on the line of demarcation of dorsal area and close one Side, left shoulder block and right shoulder block can be distributed in Y-axis two sides, neck position when distance interval between the two can make object lie down Between left shoulder block and right shoulder block, and left shoulder and right shoulder be respectively against left shoulder block and right shoulder block, so that right The shoulder of elephant is aligned with the top edge of dorsal area.In some embodiments, the interval between left shoulder block and right shoulder block can To be 130mm.In some embodiments, the interval of left shoulder block and right shoulder block can change, can be according to different statures Object can choose different intervals, for example, the evil spirit when shoulder blocks are connect using velcro with upper cover 911, in upper cover 911 The size of the circle hair of art patch can be bigger than the size of the seta on shoulder blocks, so that measurement support staff (such as medical staff) The position of shoulder blocks can be adjusted according to the stature of object.

In some embodiments, register guide 907 may include one or more foot's blocks, for example, Liang Ge foot Block is arranged on limbic areas, and when object is lain on sensing device, the foot or shank for object are against so that right The extended legs with thighs of elephant and at closing up posture.In some embodiments, foot's block can be fixedly disposed at the upper cover of ontology 901 On 911, for example, being linked together by suture with upper cover 911.In some embodiments, foot's block can also be by detachable Mode connect with upper cover 911, for example, being connect with upper cover 911 by velcro.In some embodiments, left foot block and the right side The interval of foot block can be 300mm.As shown in Figure 10, sensing device 1001 may include Liang Ge foot block 1013.One In a little embodiments, the shape of shoulder blocks and foot's block can change, and color can also change, and the application is not intended to limit outside it Shape and color.Such as the register guide of sensing device 1003 shown in Figure 10 includes that two shoulder blocks 1031 and Liang Ge foot keep off Block 1033.

In some embodiments, register guide 907 may include a neckpillow, which, which is arranged on, closes on and back The line of demarcation in region and close side are placed in center (near Y-axis).Neckpillow can be leaned on when object is lain down for neck pillow, So that the shoulder of object is aligned with the top edge of dorsal area.In some embodiments, neckpillow can be fixedly disposed at In the upper cover 911 of ontology 901, for example, being linked together by suture with upper cover 911.In some embodiments, neckpillow can also lead to It crosses dismountable mode to connect with upper cover 911, for example, connecting by velcro with upper cover 911.In some embodiments, neckpillow Shape can be cylindrical body or approximate cylindrical body to be bonded the neck physiologic radian of human body.As shown in Figure 10, sensing device 1005 register guide 1051 is one embodiment of neckpillow.

In some embodiments, sensing device 900 can also include a support plate 909.Support plate 909 is configured as One fibre optical sensor 903 and the second fibre optical sensor group 905 provide support, can be configured as and are placed in the first fibre optical sensor 903 and second under fibre optical sensor group 905, and with the first fibre optical sensor 903 and the second fibre optical sensor group 905 together by It is coated in ontology 901.Support plate 909 can be using hard structure, such as plank, PVC board etc..

Figure 11 is the schematic diagram of the register guide according to other embodiments of the application.In some embodiments, in Fig. 9 The upper cover 911 of ontology 901 can use stereochemical structure, for example, as shown in figure 11, the upper cover of sensing device 1100 may include One human body outline concave structure 1101.When object lies supine upon upper cover, body can be placed in human body contour outline sunk structure On 1101.Human body contour outline sunk structure 1101 is arranged near the Y-axis of sensing device, is symmetric along Y-axis, when object is faced upward When being horizontally-arranged in human body contour outline structure 1101, the head of object is located at sensing device 1100, and back is located at sensing device 1100 Dorsal area, waist is located at the lumbar region of sensing device 1100, and lower limb are located at the limbic areas of sensing device 1100.One In a little embodiments, different according to the height of object, sensing device can have different sizes, correspondingly, human body contour outline structure 1101 can also change with the height of object, the difference of figure.For example, being suitble to the size of height 155cm-160cm crowd Being set as No. S, then entirety increases certain size again on the basis of being suitble to the size of height 161cm-170cm crowd to can be No. S, such as 2-5cm.In some embodiments, the upper cover 911 of the ontology 901 in Fig. 9 can use planar structure, and can use has at this time The contour line of obvious identification indicates human body contour outline, such as when upper cover 911 is using white, can be marked using red lines Know human body contour outline.

It should be noted that above description is only the specific embodiment of the application, it is not considered as unique reality Apply example.For one of skill in the art, after understanding present context and principle, all may without departing substantially from In the case where the application principle, structure, various modifications and variations in form and details are carried out, but these modifications and variations are still Within claims hereof protection scope.

Claims

1. a kind of pulse transit measurement method of parameters characterized by comprising

The first vibration information of supine subject is obtained from the first fibre optical sensor, first fibre optical sensor is placed in described lie on the back Under the corresponding dorsal area of fourth dorsal vertebra body of object；

The second vibration information of the supine subject is obtained from the second fibre optical sensor, second fibre optical sensor is placed in described Under the corresponding lumbar region of fourth lumbar vertebra body of supine subject；

The first haemodynamics relevant information is generated based on first vibration information, and is generated based on second vibration information Second haemodynamics relevant information；

The aorta petal opening time of the supine subject is determined based on the first haemodynamics relevant information, and is based on institute State the pulse wave arrival time that the second haemodynamics relevant information determines the supine subject；With

Based on the aorta petal opening time and the pulse wave arrival time, the aorta pulse of the supine subject is determined Wave conduction time.

2. the method according to claim 1, wherein first fibre optical sensor or the second fibre optical sensor packet It includes:

A piece optical fiber, is arranged in the structure being located substantially in a plane；

Light source is coupled with one end of one or more optical fiber；

Receiver is coupled with the other end of an optical fiber, for perceiving the variation of the luminous intensity by the optical fiber；With one A clathrum, the mesh by being provided with opening form, wherein the clathrum is contacted with the optical fiber surface.

3. the method according to claim 1, wherein generating the first hemodynamic based on first vibration information Relevant information is learned, and the second haemodynamics relevant information is generated based on second vibration information, further comprises:

First vibration information and second vibration information are filtered respectively, scaled to generate first blood flow Mechanics relevant information and the second haemodynamics relevant information.

4. the method according to claim 1, wherein determining institute based on the first haemodynamics relevant information The aorta petal opening time for stating supine subject further comprises:

Second-order differential operation is carried out to the first haemodynamics relevant information；

To the waveform diagram of the first haemodynamics relevant information after second-order differential operation carry out signature search determine one it is aroused in interest Top in period；With

The aorta petal opening time of the supine subject is determined based on the top.

5. the method according to claim 1, wherein the method further includes:

Obtain between first fibre optical sensor and second fibre optical sensor along Human Height direction distance and generate master Arterial pulse wave conducts distance；With

Distance and the aortic pulse wave conduction time are conducted based on the aortic pulse wave, determines that aortic pulse wave passes Lead speed.

6. according to the method described in claim 5, it is characterized in that, the method further includes:

At least one of the aortic pulse wave conduction time and the aortic pulse wave conduction of velocity are sent to one Or multiple output devices.

7. a kind of pulse transit parameter measurement system, comprising:

First fibre optical sensor is placed in the fourth dorsal vertebra body near zone of supine subject, for obtaining the of the supine subject One vibration information；

Second fibre optical sensor is placed in the fourth lumbar vertebra body near zone of the supine subject, for obtaining the supine subject The second vibration information；

One or more processors；With

One or more memories, one or more of memories are stored with instruction, when described instruction is by one or more The method as described in claim 1 and 3-6 any one is realized when a processor executes.

8. system according to claim 7, which is characterized in that first fibre optical sensor and the second fibre optical sensor are equal Include:

Light source is coupled with one end of one or more optical fiber；

9. a kind of pulse transit parameter measuring apparatus characterized by comprising

Ontology, the ontology for supine subject for lying down, and the ontology includes upper cover and lower cover, and the ontology includes back region Domain and lumbar region；

First fibre optical sensor, first fibre optical sensor are placed in the dorsal area of the ontology, for obtaining described lie on the back First vibration information of object；With

Second fibre optical sensor group, including two or more fibre optical sensors, the second fibre optical sensor group are placed in described The lumbar region of body, for obtaining the second vibration information of the supine subject；

Wherein, first fibre optical sensor and the second fibre optical sensor group are coated on by the upper cover and the lower cover It is interior.

10. device according to claim 9, which is characterized in that described device further comprises neckpillow, the neckpillow setting In on the upper lid, lean on for the neck pillow for the supine subject to ensure that the supine subject is in measurement position.

11. device according to claim 9, which is characterized in that described device further comprises shoulder blocks, the shoulder Block is set on the upper lid, for the shoulder for the supine subject against to ensure that the supine subject is in measurement position It sets.

12. device according to claim 9, which is characterized in that the ontology further includes limbic areas, and described device is into one Step includes foot's block, and foot's block is set to the limbic areas of the upper cover, for the foot for the supine subject Or shank is against to ensure that the supine subject is in measurement position.

13. the device according to shown in claim 9, which is characterized in that the housing cover can use stereochemical structure, including one A human body outline concave structure is to ensure that the supine subject is in measurement position.

14. device according to claim 9, which is characterized in that two or more in the second fibre optical sensor group Fibre optical sensor is arranged along the ontology longitudinal axis.

15. device according to claim 9, which is characterized in that the fibre optical sensor includes:

Light source is coupled with one end of one or more optical fiber；